Author: "Rozec, B" / Language: english - Searchworks@Jio Institute Digital Library Search Results

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200 results on '"Rozec, B"'

1. Cost of red blood cell transfusion; evaluation in a French academic hospital

Author: Rigal, J.-C., Riche, V.P., Tching-Sin, M., Fronteau, C., Huon, J.-F., Cadiet, J., Boukhari, R., Vourc’h, M., and Rozec, B.
Published: 2020
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2. Increased β2-adrenergic vasorelaxation at the early phase of endotoxemic shock in rats

Author: Roul, D., Rozec, B., André, G., Merlet, N., Tran Quang, T., Lauzier, B., Ferron, M., Blanloeil, Y., Loirand, G., Sauzeau, V., and Gauthier, C.
Published: 2015
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3. ESICM LIVES 2016: part two: Milan, Italy. 1–5 October 2016

Author: Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Lazaridis, C., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Taccone, F. S., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. V., Tsvetanova-Spasova, T., Nuevo-Ortega, P., Rueda-Molina, C., Fernández-Porcel, A., Camara-Sola, E., Salido-Díaz, L., García-Alcántara, A., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, D. E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., Suberviola, B., Riera, J., Rellan, L., Sanchez, M., Robles, J. C., Lopez, E., Vicente, R., Miñambres, E., Santibañez, M., Le Guen, M., Moore, J., Mason, N., Windpassinger, M., Plattner, O., Mascha, E., Sessler, D. I., Research, Outcomes, Melia, U., Fontanet, J., van den Berg, J. P., Struys, M. M. R. F., Vereecke, H. E. M., Jensen, E. W., Rood, P. J. T., van de Schoor, F., van Tertholen, K., Pickkers, P., van den Boogaard, M., Beardow, Z. J., Redhead, H., Paramasivam, K., Numan, T., van den Boogaard, M., Kamper, A. M., Rood, P., Peelen, L. M., Zeman, P. M., Slooter, A. J., van Ewijk, C. E., Jacobs, G. E., Girbes, A. R. J., Myatra, S. N., Harish, M. M., Prabu, N. R., Siddiqui, S., Kulkarni, A. P., Divatia, J. V., Murbach, L. D., Leite, M. A., Osaku, E. F., Costa, C. R. L. M., Pelenz, M., Neitzke, N. M., Moraes, M. M., Jaskowiak, J. L., Silva, M. M. M., Zaponi, R. S., Abentroth, L. R. L., Ogasawara, S. M., Jorge, A. C., Duarte, P. A. D., Hernández-Sánchez, N., Sánchez-Hurtado, L. A., García-Guillen, F. J., Ñamendys-Silva, S. A., Maghsoudi, B., Emami, M., Khosravi, M. B., Zand, F., Tabatabaie, H. R., Masjedi, M., Sabetiyan, G., Mokri, A., Troubleyn, J., Diltoer, M., Jacobs, R., Nguyen, D. N., De Waele, E., De Regt, J., Honoré, P. M., Van Gorp, V., Spapen, H. D., Contreras, R. S., Toapanta, N. D., Moreno, G., Sabater, J., Torrado, H., Gonzalez, M., Marin, M., Farigola, E., Gonzalez, A., Fernandez, J., Vera, A., Gisbert, X., Juliá, C., Uya, J., Corral, L., Elias-Jones, I., Gemmell, L., MacKay, A., Randall, D., Adwaney, A., Blunden, M., Prowle, J. R., Kirwan, C. J., Thomas, N., Martin, A., Owen, H., Darwin, L., Conway, D., Atkinson, D., Sharman, M., Moore, J., Barbanti, C., Amour, J., Gaudard, P., Rozec, B., Mauriat, P., M’rini, M., Leger, P. L., Cambonie, G., Liet, J. M., Girard, C., Laroche, S., Damas, P., Assaf, Z., Loron, G., Lecourt, L., Pouard, P., Randall, D., Adwaney, A., Blunden, M., Prowle, J.R., Kirwan, C. J., Kim, S. H., Na, S., Kim, J., Oh, S. Y., Jung, C. W., Yoo, S. H., Min, S. H., Chung, E. J., Lee, H., Lee, N. J., Lee, K. W., Suh, K. S., Ryu, H. G., Marshall, D. C., Goodson, R. J., Salciccioli, J. D., Shalhoub, J., Potter, E. K., Kirk-Bayley, J., Karanjia, N. D., Forni, L. G., Creagh-Brown, B. C., Bossy, M., Nyman, M., Tailor, A., Creagh-Brown, B., D’Antini, D., Spadaro, S., Valentino, F., Sollitto, F., Cinnella, G., Mirabella, L., Calvo, F. J. Redondo, Bejarano, N., Padilla, D., Baladron, V., Villajero, P., Villazala, R., Redondo, J., Yuste, A. S., Liu, J., Shen, F., Teboul, J. L., Anguel, N., Beurton, A., Bezaz, N., Richard, C., Monnet, X., Fossali, T., Colombo, R., Ottolina, D., Rossetti, M., Mazzucco, C., Marchi, A., Porta, A., Catena, E., Tollisen, K. H., Andersen, G. Ø., Heyerdahl, F., Jacobsen, D., de Waard, M. C., Girbes, A. R. J., van IJzendoorn, M. C. O., Buter, H., Kingma, W. P., Navis, G. J., Boerma, E. C., Rulisek, J., Balik, M., Zacharov, S., Kim, H. S., Jeon, S. J., Namgung, H., Lee, E., Lee, E., Cho, Y. J., Lee, Y. J., Huang, A., Cioccari, L., Luethi, N., Mårtensson, J., Bellomo, R., Forsberg, M., Edman, G., Höjer, J., Forsberg, S., Freile, M. T. Chiquito, Hidalgo, F. N., Molina, J. A. Martinez, Lecumberri, R., Rosselló, A. Figuerola, Travieso, P. Medrano, Leon, G. Tuero, Sanchez, J. Gonzalez, Frias, L. Sahuquillo, Rosello, D. Balsells, Verdejo, J. A. Garcia, Serrano, J. A. Noria, Winterwerp, D., van Galen, T., Vazin, A., Karimzade, I., Zand, A., Ozen, E., Ekemen, S., Akcan, A., Sen, E., Yelken, B. Buyukkidan, Kureshi, N., Fenerty, L., Thibault-Halman, G., Erdogan, M., Walling, S., Green, R. S., Clarke, D. B., Briassoulis, P., Kalimeris, K., Ntzouvani, A., Nomikos, T., Papaparaskeva, K., Politi, E., Kostopanagiotou, G., Crewdson, K., Rehn, M., Weaver, A., Brohi, K., Lockey, D., Wright, S., Thomas, K., Baker, C., Mansfield, L., Stafford, V., Wade, C., Watson, G., Bryant, A., Chadwick, T., Shen, J., Wilkinson, J., Furneval, J., Henderson, A., Hugill, K., Howard, P., Roy, A., Bonner, S., Baudouin, S., Ramírez, C. Sánchez, Escalada, S. Hípola, Viera, M. A. Hernández, Santana, M. Cabrera, Balcázar, L. Caipe, Monroy, N. Sangil, Campelo, F. Artiles, Vázquez, C. F. Lübbe, Santana, P. Saavedra, Santana, S. Ruiz, Carteron, L., Patet, C., Quintard, H., Solari, D., Bouzat, P., Oddo, M., Wollersheim, T., Malleike, J., Haas, K., Carbon, N., Schneider, J., Birchmeier, C., Fielitz, J., Spuler, S., Weber-Carstens, S., Enseñat, L., Pérez-Madrigal, A., Saludes, P., Proença, L., Gruartmoner, G., Espinal, C., Mesquida, J., Huber, W., Eckmann, M., Elkmann, F., Gruber, A., Lahmer, T., Mayr, U., Herner, A., Schellnegger, R., Schneider, J., Schmid, R. M., Ayoub, W., Samy, W., Esmat, A., Battah, A., Mukhtar, S., Mongkolpun, W., Cortés, D. Orbegozo, Cordeiro, C. P. R., Vincent, J. L., Creteur, J., Funcke, S., Groesdonk, H., Saugel, B., Wagenpfeil, G., Wagenpfeil, S., Reuter, D. A., Fernandez, M. M., Fernandez, R., Magret, M., González-Castro, A., Bouza, M. T., Ibañez, M., García, C., Balerdi, B., Mas, A., Arauzo, V., Añón, J. M., Ruiz, F., Ferreres, J., Tomás, R., Alabert, M., Tizón, A. I., Altaba, S., Llamas, N., Goligher, E C., Fan, E., Herridge, M., Vorona, S., Sklar, M., Dres, M., Rittayamai, N., Lanys, A., Urrea, C., Tomlinson, G., Reid, W. D., Rubenfeld, G. D., Kavanagh, B. P., Brochard, L. J., Ferguson, N. D., Neto, A. Serpa, de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Guérin, C., Papazian, L., Reignier, J., Ayzac, L., Loundou, A., Forel, J. M., Rolland-Debord, C., Bureau, C., Poitou, T., Clavel, M., Perbet, S., Terzi, N., Kouatchet, A., Similowski, T., Demoule, A., Hunfeld, N., Trogrlic, Z., Ladage, S., Osse, R. J., Koch, B., Rietdijk, W., Devlin, J., van der Jagt, M., Picetti, E., Ceccarelli, P., Mensi, F., Malchiodi, L., Risolo, S., Rossi, I., Antonini, M. V., Servadei, F., Caspani, M. L., Roquilly, A., Lasocki, S., Seguin, P., Geeraerts, T., Perrigault, P. F., Dahyot-Fizelier, C., Paugam-Burtz, C., Cook, F., Cinotti, R., dit Latte, D. Demeure, Mahe, P. J., Fortuit, C., Feuillet, F., Asehnoune, K., Marzorati, C., Spina, S., Scaravilli, V., Vargiolu, A., Riva, M., Giussani, C., Sganzerla, E., Citerio, G., Barbadillo, S., de Molina, F. J. González, Álvarez-Lerma, F., Rodríguez, A., Zakharkina, T., Martin-Loeches, I., Matamoros, S., Povoa, P., Torres, A., Kastelijn, J., Hofstra, J. J., de Jong, M., Schultz, M., Sterk, P., Artigas, A., Bos, L. J., Moreau, A. S., Martin-Loeches, I., Povoa, P., Salluh, J., Rodriguez, A., Nseir, S., de Jong, E., van Oers, J. A., Beishuizen, A., Girbes, A. R. J., Nijsten, M. W. N., de Lange, D. W., Bonvicini, D., Labate, D., Benacchio, L., Olivieri, A., Pizzirani, E., Lopez-Delgado, J. C., Gonzalez-Romero, M., Fuentes-Mila, V., Berbel-Franco, D., Romera-Peregrina, I., Martinez-Pascual, A., Perez-Sanchez, J., Abellan-Lencina, R., Ávila-Espinoza, R. E., Moreno-Gonzalez, G., Sbraga, F., Griffiths, S., Grocott, M. P. W., Creagh-Brown, B., Doyle, J., Wilkerson, P., Soon, Y., Huddart, S., Dickinson, M., Riga, A., Zuleika, A., Miyamoto, K., Kawazoe, Y., Morimoto, T., Yamamoto, T., Fuke, A., Hashimoto, A., Koami, H., Beppu, S., Katayama, Y., Ito, M., Ohta, Y., Yamamura, H., Rygård, S. L., Holst, L B., Wetterslev, J., Johansson, P. I., Perner, A., Soliman, I. W., de Lange, D. W., van Dijk, D., van Delden, J. J. M., Cremer, O. L., Slooter, A. J. C., Peelen, L. M., McWilliams, D., Snelson, C., Neves, A. Das, Loudet, C. I., Busico, M., Vazquez, D., Villalba, D., Veronesi, M., Lischinsky, A., López, F. J. L., Mori, L. Benito, Plotnikow, G., Díaz, A., Giannasi, S., Hernandez, R., Krzisnik, L., Cecotti, C., Viola, L., Lopez, R., Sottile, J. P., Benavent, G., Estenssoro, E., Chen, C. M., Lai, C. C., Cheng, K. C., Chou, W., Chan, K. S., Roeker, L. E., Horkan, C. M., Gibbons, F. K., Christopher, K. B., Weijs, P. J. M., Mogensen, K. M., Rawn, J. D., Robinson, M. K., Christopher, K. B., Tang, Z., Qiu, C., Ouyang, B., Cai, C., Guan, X., Regueira, T., Cea, L., Carlos, S. Juan, Elisa, B., Puebla, C., Vargas, A., Poulsen, M. K., Thomsen, L. P., Kjærgaard, S., Rees, S. E., Karbing, D. S., Wollersheim, T., Frank, S., Müller, M. C., Carbon, N. M., Skrypnikov, V., Pickerodt, P. A., Falk, R., Mahlau, A., Weber-Carstens, S., Lee, A., Inglis, R., Morgan, R., Barker, G., Kamata, K., Abe, T., Saitoh, D., Tokuda, Y., Green, R. S., Butler, M. B., Erdogan, M., Hwa, H. Tae, Gil, L. Jae, Vaquero, R. Hernández, Rodriguez-Ruiz, E., Lago, A. Lopez, Allut, J. L. Garcia, Gestal, A. Estany, Gonzalez, M. A. Garcia, Thomas-Rüddel, D. O., Schwarzkopf, D., Fleischmann, C., Reinhart, K., Suwanpasu, S., Sattayasomboon, Y., Filho, N. M. Filgueiras, Oliveira, J. C. A., Ballalai, C. S., De Lucia, C. V., Araponga, G. P., Veiga, L. N., Silva, C. S., Garrido, M. E., Ramos, B. B., Ricaldi, E. F., Gomes, S. S., Gemmell, L., MacKay, A., Wright, C., Docking, R. I., Doherty, P., Black, E., Stenhouse, P., Plummer, M. P., Finnis, M. E., Phillips, L. K., Kar, P., Bihari, S., Biradar, V., Moodie, S., Horowitz, M., Shaw, J. E., Deane, A. M., Yatabe, T., Inoue, S., Sakaguchi, M., Egi, M., Abdelhamid, Y. Ali, Plummer, M. P., Finnis, M. E., Phillips, L. K., Kar, P., Bihari, S., Biradar, V., Moodie, S., Horowitz, M., Shaw, J. E., Deane, A. M., Hokka, M., Egi, M., Mizobuchi, S., Kar, P., Plummer, M., Abdelhamid, Y. Ali, Giersch, E., Summers, M., Hatzinikolas, S., Heller, S., Chapman, M., Jones, K., Horowitz, M., Deane, A., Schweizer, R., Jacquet-Lagreze, M., Portran, P., Junot, S., Allaouchiche, B., Fellahi, J. L., Guerci, P., Ergin, B., Kapucu, A., Ince, C., Cioccari, L., Luethi, N., Crisman, M., Bellomo, R., Mårtensson, J., Shinotsuka, C. Righy, Fagnoul, D., Brasseur, A., Orbegozo, D., Vincent, J. L., Preiser, J. C., Preiser, J. C., Lheureux, O., Thooft, A., Brimioulle, S., Vincent, J. L., Iwasaka, H., Tahara, S., Nagamine, M., Ichigatani, A., Cabrera, A. Rugerio, Zepeda, E. Monares, Granillo, J. Franco, Sánchez, J. S. Aguirre, Montoya, A. A. Tanaka, Montenegro, A. Pedraza, Blanco, G. A. Gálvez, Robles, C. M. Coronado, Drolz, A., Horvatits, T., Roedl, K., Rutter, K., Kluge, S., Funk, G. C., Schneeweiss, B., Fuhrmann, V., Sabetian, G., Pooresmaeel, F., Zand, F., Ghaffaripour, S., Farbod, A., Tabei, H., Taheri, L., Anandanadesan, R., Metaxa, V., Teixeira, C., Pereira, S. M., Hernández-Marrero, P., Carvalho, A. S., Beckmann, M., Hartog, C. S., Schwarzkopf, D., Raadts, A., Robertsen, A., Førde, R., Skaga, N. O., Helseth, E., Honeybul, S., Ho, K., Lopez, P. Martinez, Gonzalez, M. Nieto, Ortega, P. Nuevo, Sola, E. Camara, Spasova, T., de la Torre-Prados, M. V., Kopecky, O., Rusinova, K., Waldauf, P., Cepeplikova, Z., Balik, M., Domínguez, J. Palamidessi, Almudevar, P. Matia, Carmona, S. Alcántara, Muñoz, J. J. Rubio, Castañeda, D. Palacios, Abellán, A. Naharro, Villamizar, P. Rodríguez, Ramos, J. Veganzones, Pérez, L. Pérez, Lucendo, A. Pérez, Ejarque, M. Camós, Estella, A., Camps, V. Lopez, Martín, M. C., Masnou, N., Barbosa, S., Varela, A., Palma, I., Cristina, L., Nunes, E., Pereira, I., Campello, G., Granja, C., Pande, R., Pandey, M., Varghese, S., Chanu, M., Van Dam, M. J., Ter Braak, E. W. M. T., Estella, A., Gracia, M., Viciana, R., Recuerda, M., Fontaiña, L. Perez, Tharmalingam, B., Kovari, F., Rose, L., Mcginlay, M., Amin, R., Burns, K., Connolly, B., Hart, N., Jouvet, P., Katz, S., Leasa, D., Mawdsley, C., Mcauley, D., Schultz, M., Blackwood, B., Denham, S., Worrall, R., Arshad, M., Isherwood, P., Khadjibaev, A., Sabirov, D., Rosstalnaya, A., Parpibaev, F., Sharipova, V., Blanco, G. A. Galvez, Guzman, C. I. Olvera, Sánchez, J. S. Aguirre, Granillo, J. Franco, Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Shafi, M., Tomar, D. S., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Cha, Y. S., Lee, S. J., Tyagi, N., Rajput, R. K., Taneja, S., Singh, V. K., Sharma, S. C., Mittal, S., Rao, B. K., Ayachi, J., Fraj, N., Romdhani, S., Khedher, A., Meddeb, K., Sma, N., Azouzi, A., Bouneb, R., Chouchene, I., El Ghardallou, M., Boussarsar, M., Jennings, R., Walter, E., Ribeiro, J. M., Moniz, I., Marçal, R., Santos, A. C., Candeias, C., e Silva, Z. Costa, Gomez, S. E. Zamora, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Cuellar, A. I. Vasquez, Mildh, H., Pettilä, V., Korhonen, A. M., Karlsson, S., Ala-Kokko, T., Reinikainen, M., Vaara, S. T., Zaleska-Kociecka, M., Grabowski, M., Dąbrowski, M., Wozniak, S., Piotrowska, K., Banaszewski, M., Imiela, J., Stepinska, J., Pérez, A. González, Ordoñez, P. Florez, Giribet, A., Cuervo, M. A. Alonso, Cuervo, R. Alonso, Esteban, M. A. Rodriguez, Fraile, L. Iglesias, Mittelbrum, C. Ponte, Albaiceta, G. Muñiz, Koeze, J., Keus, F., Dieperink, W., van der Horst, I. C. C., van Meurs, M., Zijlstra, J. G., Roberts, S., Caballero, C. 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Rubatto, Ince, C., Dubin, A., Dogliotti, A., Ramos, A., Lovesio, C., Delile, E., Nevière, R., Thiébaut, P.-A., Maupoint, J., Mulder, P., Coquerel, D., Renet, S., do Rego, J. C., Rieusset, J., Richard, V., Tamion, F., Khaliq, W., Andreis, D. T., Singer, M., Smit, B., Smulders, Y. M., de Waard, M. C., van Straaten, H. M. Oudemans, Girbes, A. R. J., Eringa, E. C., Man, A. M. E. Spoelstra-de, Alegría, L., Soto, D., Luengo, C., Gomez, J., Jarufe, N., Bruhn, A., Castro, R., Kattan, E., Tapia, P., Rebolledo, R., Achurra, P., Ospina-Tascón, G., Bakker, J., Hernández, G., Bertini, P., Guarracino, F., Baldassarri, R., Pinsky, M. R., Alegría, L., Vera, M., Dreyse, J., Carpio, D., Henriquez, C., Gajardo, D., Bravo, S., Castro, R., Ospina-Tascón, G., Bakker, J., Hernández, G., Kim, S., Lee, M., Park, S. Y., So, S., Lee, H., Kačar, M. B., Kačar, S. M., Uddin, I., Belhaj, A. M., Aydın, M. 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E., Sinha, K., Luney, M., Palmer, K., Keating, L., Abu-Habsa, M., Bahl, R., Baskaralingam, N., Ahmad, A., Kanapeckaite, L., Bhatti, P., Glace, S., Jeyabraba, S., Lewis, H. F., Kostopoulos, A., Raja, M., West, A., Ely, A., Turkoglu, L. M., Zolfaghari, P., Baptista, J. P., Marques, M. P., Martins, P., Pimentel, J., Gupta, D., Su, Y. C., Villacres, S., Stone, M. E., Parsikia, A., Medar, S., O’Dea, K. P., Porter, J., Tirlapur, N., Jonathan, J. M., Singh, S., Takata, M., Abu-Habsa, M., Ahmad, A., McWhirter, E., Lyon, R., Hariz, M. L., Azmi, E., Alkhan, J., Honeybul, S., Movsisyan, V., Petrikov, S., Marutyan, Z., Aliev, I., Evdokimov, A., Antonucci, E., Merz, T., Hartmann, C., Pelosi, P., Calzia, E., Radermacher, P., Nußbaum, B., Hartmann, C., Huber-Lang, M., Gröger, M., Radermacher, P., Nußbaum, B., Nußbaum, B., Antonucci, E., Calzia, E., Pelosi, P., Radermacher, P., Hartmann, C., Svoren-Jabalera, E., Davenport, E. E., Humburg, P., Knight, J., Hinds, C. J., Jun, I. J., Kim, W. J., Lee, E. H., Besch, G., Perrotti, A., Puyraveau, M., Carteron, L., Baltres, M., Samain, E., Chocron, S., Pili-Floury, S., Plata-Menchaca, E. P., Sabater-Riera, J., Estruch, M., Boza, E., Sbraga, F., Toscana-Fernández, J., Bruguera-Pellicer, E., Ordoñez-Llanos, J., Pérez-Fernández, X. L., Cavaleiro, P., Tralhão, A., Arrigo, M., Lopes, J.-P., Lebrun, M., Cholley, B., PerezVela, J. L., MarinMateos, H., Rivera, J. J. Jimenez, Llorente, M. A. Alcala, De Marcos, B. Gonzalez, Fernandez, F. J. Gonzalez, Laborda, C. Garcia, Zamora, D. Fernandez, Delgado, J. C. Lopez, Imperiali, C., Berbel-Franco, D., Dastis, M., Moreno-Gonzalez, G., Perez-Sanchez, J., Romera-Peregrina, I., Abellan-Lencina, R., Martinez-Pascual, A., Fuentes-Mila, V., Gonzalez-Romero, M., Górka, J., Górka, K., Iwaniec, T., Frołow, M., Polok, K., Fronczek, J., Kózka, M., Musiał, J., Szczeklik, W., Pérez, A. González, Ordoñez, P. Florez, Giribet, A., Cuervo, M. A. Alonso, Cuervo, R. Alonso, Esteban, M. A. Rodriguez, Fraile, L. Iglesias, Mittelbrum, C. Ponte, Albaiceta, G. Muñiz, Ampatzidou, F., Sileli, M., Kehagioglou, G., Madesis, A., Karaiskos, T., Moursia, C., Maleoglou, H., Leleki, K., Drossos, G., Uz, Z., Ince, Y., Papatella, R., Bulent, E., Guerci, P., Ince, C., De Mol, B., Vicka, V., Gineityte, D., Ringaitiene, D., Norkiene, I., Sipylaite, J., Möller, C., Fleischmann, C., Thomas-Rueddel, D. O., Vlasakov, V., Rochwerg, B., Theurer, P., Gattinoni, L., Reinhart, K., Hartog, C. S., Pérez, A. González, Al Sibai, J. Zanabili, Camblor, P. Martinez, Fernandez, P. Alvarez, Gala, J. M. García, Guisasola, J. Silba, Albaiceta, G. Muñiz, Tamura, T., Yatabe, T., Miyajima, I., Yamashita, K., Yokoyama, M., Ampatzidou, F., Kehagioglou, G., Dalampini, E., Nastou, M., Baddour, A., Ignatiadis, A., Asteri, T., Drossos, G., Hathorn, K. E., Purtle, S. W., Horkan, C. M., Gibbons, F. K., Christopher, K. B., Viana, M. V., Tonietto, T. A., Gross, L. A., Costa, V. L., Tavares, A. L. J., Lisboa, B. O., Moraes, R. B., Vieira, S. R., Viana, L. V., Azevedo, M. J., Ceniccola, G. D., Pequeno, R. S. F., Holanda, T. P., Mendonça, V. S., Araújo, W. M. C., Carvalho, L. S. F., Segaran, E., Vickers, L., Brinchmann, K., Wignall, I., Rubulotta, F., De Brito-Ashurst, I., del Olmo, R., Esteban, M. J., Vaquerizo, C., Carreño, R., Gálvez, V., Kaminsky, G., Nieto, B., Fuentes, M., De la Torre, M. A., Torres, E., Alonso, A., Velayos, C., Saldaña, T., Escribá, A., GRIP, J., Kölegård, R., Sundblad, P., Rooyackers, O., Naser, Ben, Jaziri, F., Jazia, A. Ben, Barghouth, M., Hentati, O., Skouri, W., El Euch, M., Mahfoudhi, M., Turki, S., Abdelghni, K. Ben, Abdallah, Ben, Maha, B. N. M., Cánovas, J., Sotos, F., López, A., Lorente, M., Burruezo, A., Torres, D., Polok, K., Włudarczyk, A., Górka, J., Hałek, A., Musiał, J., Szczeklik, W., Jazia, A. Ben, Jaziri, F., Bargouth, M., Bennasr, M., Turki, S., Abdelghani, K. Ben, Abdallah, T. Ben, de Grooth, H. J., Geenen, I. L., Parienti, J. J., Straaten, H. M. Oudemans-van, Shum, H. P., King, H. S., Chan, K. C., Yan, W. W., Londoño, J. Gonzalez, Cardenas, C. Lorencio, Pedrosa, M. Morales, Gubianas, C. Murcia, Bertolin, C. Fuster, Batllori, N. Vila, Sirvent, J. M., Wykes, K., Jack, J., Morgan, P., Mukhopadhyay, A., Chan, H. Y., Kowitlawakul, Y., Remani, D., Leong, C. S. F., Henry, C. J., Puthucheary, Z. A., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M., Espinoza, E. D. Valenzuela, Welsh, S. P., Motta, M. F., Guerra, E., Zerpa, M. C. l., Zechner, F., Furche, M., Berdaguer, F., Birri, P. N. Rubatto, Risso-Vazquez, A., Dubin, A., Masevicius, F. D., Greaney, D., Magee, A., Fitzpatrick, G., Lugo-Cob, R. G., Sánchez-Hurtado, L. A., Arvizu-Tachiquín, P. C., Tejeda-Huezo, B. C., Cano-Oviedo, A. A., Baltazar-Torres, J. A., Aydogan, M. S., Togal, T., Taha, A., Chai, H. Z., Kam, C., Razali, S. S. Yang, Sivasamy, V., Kuan, L. Y., Poulose, V., Morales, M. A. Lopez, Castro, S., Pires, T., Melão, L., Krystopchuk, A., Pereira, I., Granja, C., Taniguchi, L. U., Pires, E. M. C., Vieira, Jr, J. M., Azevedo, L. C. P., Nurses of the Central and General ICUs of Shiraz Namazi Hospital, Sedation an Delirium Group Hospital Universitari de Bellvitge, SPACeR group (Surrey Peri-operative, Anaesthesia and Critical Care Collaborative Research Group), for the PRoVENT investigators and the PROVE Network, SEMICYUC/GETGAG Working Group, TAVeM study group, POPC-CB investigators, DESIRE (DExmedetomidine for Sepsis in ICU Randomized Evaluation) Trial Investigators, GEMINI, Bioethics work group of SEMICYUC, The FINNAKI Study Group, Queen Square Neuroanaesthesia and Neurocritical Care Resreach Group, Renal Transplantation HUVR, GEMINI, EDISVAL Group, EDISVAL Group, PLUG Working group, TAVeM study Group, The FINNAKI Study Group, on behalf of Department of Professional Development, ESICM, Critical Care Research Group, SIRAKI group, and Grupo ESBAGA
Published: 2016
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4. Change in end-tidal carbon dioxide outperforms other surrogates for change in cardiac output during fluid challenge

Author: Lakhal, K., Nay, M. A., Kamel, T., Lortat-Jacob, B., Ehrmann, S., Rozec, B., and Boulain, T.
Published: 2017
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5. Risk factors and pathogens involved in early ventilator-acquired pneumonia in patients with severe subarachnoid hemorrhage

Author: Cinotti, R., Dordonnat-Moynard, A., Feuillet, F., Roquilly, A., Rondeau, N., Lepelletier, D., Caillon, J., Asseray, N., Blanloeil, Y., Rozec, B., and Asehnoune, K.
Published: 2014
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6. Sodium potassium pump: A novel O-GlcNAc protein beneficial in hemorrhagic shock situation

Author: Vergnaud, A., Dupas, T., Aillerie, V., Persello, A., Pele, T., Blangy-Letheule, A., Erraud, A., Girardeau, A., Ribeiro, B., Montnach, J., De Waard, M., Rozec, B., and Lauzier, B.
Published: 2024
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7. A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study

Author: GuÃ©rin, C., Beuret, P., Constantin, J. M., Bellani, G., Garcia-Olivares, P., Roca, O., Meertens, J. H., Maia, P. Azevedo, Becher, T., Peterson, J., Larsson, A., Gurjar, M., Hajjej, Z., Kovari, F., Assiri, A. H., Mainas, E., Hasan, M. S., Morocho-Tutillo, D. R., Baboi, L., ChrÃ©tien, J. M., FranÃ§ois, G., Ayzac, L., Chen, L., Brochard, L., Mercat, A., Hajjej, Zied, Sellami, Walid, Ferjani, M., Gurjar, Mohan, Assiri, Amer, Al Bshabshe, Ali, Almekhlafi, Ghaleb, Mandourah, Yasser, Hasan, Mohd Shahnaz, Rai, Vineya, Marzida, M., Corcoles Gonzalez, Virgilio, Sanchez Iniesta, Rafael, Garcia, Pablo, Garcia-Montesinos de la PeÃ±a, Manuel, Garcia Herrera, Adriana, Roca, Oriol, Garcia-de-Acilu, Marina, Masclans Enviz, Joan Ramon, Mancebo, Jordi, Heili, Sarah, Artigas Raventos, Antonio, Blanch Torra, LluÃs, Roche-Campo, Ferran, Rialp, Gemma, Forteza, Catalina, Berrazueta, Ana, Martinez, Esther, Penuelas, Oscar, Jara-Rubio, Ruben, Mallat, Jihad, Thevenin, D., Zogheib, Elie, Mercat, Alain, Levrat, Albrice, Porot, Veronique, Bedock, B., Grech, Ludovic, Plantefeve, Gaetan, Badie, Julio, Besch, Guillaume, Pili-Floury, SÃ©bastien, Guisset, Olivier, Robine, Adrien, Prat, Gwenael, Doise, Jean-Marc, Badet, Michel, Thouret, J. M., Just, Bernard, Perbet, SÃ©bastien, Lautrette, Alexandre, Souweine, B., Chabanne, Russell, Danguy des DÃ©serts, Marc, Rigaud, Jean-Philippe, Marchalot, Antoine, Rigaud, J. P., Bele, Nicolas, Beague, SÃ©bastien, Hours, Sandrine, Marque, Sophie, Durand, Michel, Payen, J. F., Stoclin, Annabelle, Gaffinel, Alain, Winer, Arnaud, Chudeau, Nicolas, Tirot, Patrice, Thyrault, Martial, Paulet, RÃ©mi, Thyrault, M., Aubrun, Frederic, Guerin, Claude, Floccard, Bernard, Rimmele, T., Argaud, Laurent, Hernu, Romain, Crozon Clauzel, Jullien, Wey, Pierre-FranÃ§ois, Bourdin, Gael, Pommier, C., Cueuille, NadÃge, de Varax, null, Marchi, Elisa, Papazian, L., Jochmans, Sebastien, Monchi, M., Jaber, Samir, de Jong, Audrey, Moulaire, Valerie, Capron, Matthieu, Jarrige, L., Barberet, Guillaume, Lakhal, Karim, Rozec, B., Dellamonica, Jean, Robert, Alexandre, Bernardin, G., Danin, Pierre-Eric, Raucoules, M., Runge, Isabelle, Foucrier, Arnaud, Hamada, Sophie, Tesniere, Antoine, Fromentin, MÃ©lanie, Samama, C. M., Mira, Jean-Paul, Diehl, Jean-Luc, Mekontso Dessap, Armand, Arbelot, Charlotte, Demoule, Alexandre, Roche, Anne, Similowski, T., Ricard, Jean-Damien, Gaudry, StÃ©phane, Dreyfuss, D., de Montmolin, Etienne, da Silva, Daniel, Verdiere, B., Ardisson, Fanny, Lemiale, Virginie, Azoulay, Elie, Bruel, CÃ©dric, Tiercelet, Kelly, Fartoukh, Muriel, Voiriot, Guillaume, Hoffmann, Clement, Leclerc, T., Thille, Arnaud, Robert, RÃ©nÃ©, Beuret, Pascal, Beduneau, GaÃ«tan, Beuzelin, Marion, Tamion, F., Morel, JÃ©rÃ´me, Tremblay, Aymeric, Molliex, S., Amal, Jean-Michel, Meaudre, Eric, Goutorbe, Philippe, Laffon, Marc, Gros, Antoine, Nica, Alexandru, Barjon, Genevieve, Dahyot-Fizelier, Claire, Imzi, Nadia, Gally, Josette, Real, null, Sauneuf, Bertrand, Souloy, Xavier, Girbes, Armand, Tuinman, Pieter Roel, Schultz, Marcus, Winters, Tineke, Mijzen, Lisa, Roekaerts, P. M. H. J., Vermeijden, Wytze, Beishuizen, Albertus, Trof, R., Corsten, Stijn, Kesecioglu, Jozef, Meertens, John, Dieperink, Wim, Pickers, Peter, Roovers, Noortje, Maia, Paulo, Duque, Melanie, Rua, Fernando, Pereira de Figueired, AntÃ³nio Manuel, Ramos, Armindo, Fragoso, Elsa, Azevedo, Pilar, Gouveia, Joao, Costa E. Silva, ZÃ©lia, Silva, Goncalo, Chaves, Susana, Nobrega, J. J., Lopes, LuÃs, Valerio, Bernardino, Araujo, Ana Carolina, de Freitas, Paulo Telles, Bouw, Maria Jose, Melao, Maria, Granja, C., Marcal, Paulo, Fernandes, Antero, Joao, GonÃ§alves Pereira, Maia, DionÃsio Faria, Spadaro, Savino, Volta, Carlo Alberto, Bellani, Giacomo, Citerio, G., Mauri, Tommaso, Alban, Laura, Pesenti, A., Mistraletti, Giovanni, Formenti, Paolo, Tommasino, C., Tardini, Francesca, Fumagalli, R., Colombo, Riccardo, Fossali, Tommaso, Catena, E., Todeschini, Manuel, Gnesin, Paolo, Cracchiolo, Andrea Neville, Palma, Daniela, Tetamo, R., Albiero, Daniela, Costantini, Elena, Raimondi, F., Coppadoro, Andrea, Vascotto, Ettore, Lusenti, F., Becher, Tobias, SchÃ¤dler, Dirk, Weiler, N., Karagiannidis, Christian, Petersson, Johan, Konrad, D., Kawati, Rafael, Wessbergh, Joanna, Valtysson, J., Rockstroh, Matthias, Borgstrom, Sten, Larsson, Niklas, Thunberg, J., Camsooksai, Julie, Briggs, null, Kovari, Ferenc, Cuesta, J., Anwar, Sibs, Oâ€™Brien, B., Barberis, Luigi, Sturman, J., Mainas, Efstratios, Karatzas, S., Piza, Petr, Sottiaux, Thierry, Adam, J. F., Gawda, Ryszard, Gawor, Maen, Alqdah, M., Cohen, D., Brochard, Laurent, Baker, A., Ã‘amendys-Silva, Silvio Antonio, Garcia-Guillen, Francisco Javier, Morocho Tutillo, Diego Rolando, Jibaja Vega, Manuel, Zakalik, Graciela, Pagella, Gonzalo, Marengo, J., KARLI, Mélanie, Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Université de Lyon, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Génétique, Reproduction et Développement (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Hospital General Universitario 'Gregorio Marañón' [Madrid], Vall d'Hebron University Hospital [Barcelona], CIBER de Epidemiología y Salud Pública (CIBERESP), University Medical Center Groningen [Groningen] (UMCG), Centro Hospitalar do Porto, Karolinska University Hospital [Stockholm], Karolinska Institutet [Stockholm], Uppsala University, University of Malaya [Kuala Lumpur, Malaisie], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Keenan Research Centre of the Li Ka Shing Knowledge Institute [Toronto], Université d'Angers - Faculté de médecine (UA UFR Médecine), Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Other departments, Intensive Care Medicine, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, ACS - Microcirculation, Critical Care, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Université d'Angers (UA), Guã©rin, C, Beuret, P, Constantin, J, Bellani, G, Garcia-Olivares, P, Roca, O, Meertens, J, Maia, P, Becher, T, Peterson, J, Larsson, A, Gurjar, M, Hajjej, Z, Kovari, F, Assiri, A, Mainas, E, Hasan, M, Morocho-Tutillo, D, Baboi, L, Chrã©tien, J, Franã§ois, G, Ayzac, L, Chen, L, Brochard, L, Mercat, A, Sellami, W, Ferjani, M, Al Bshabshe, A, Almekhlafi, G, Mandourah, Y, Rai, V, Marzida, M, Corcoles Gonzalez, V, Sanchez Iniesta, R, Garcia, P, Garcia-Montesinos de la PeÃ±a, M, Garcia Herrera, A, Garcia-de-Acilu, M, Masclans Enviz, J, Mancebo, J, Heili, S, Artigas Raventos, A, Blanch Torra, L, Roche-Campo, F, Rialp, G, Forteza, C, Berrazueta, A, Martinez, E, Penuelas, O, Jara-Rubio, R, Mallat, J, Thevenin, D, Zogheib, E, Levrat, A, Porot, V, Bedock, B, Grech, L, Plantefeve, G, Badie, J, Besch, G, Pili-Floury, S, Guisset, O, Robine, A, Prat, G, Doise, J, Badet, M, Thouret, J, Just, B, Perbet, S, Lautrette, A, Souweine, B, Chabanne, R, Danguy des DÃ©serts, M, Rigaud, J, Marchalot, A, Bele, N, Beague, S, Hours, S, Marque, S, Durand, M, Payen, J, Stoclin, A, Gaffinel, A, Winer, A, Chudeau, N, Tirot, P, Thyrault, M, Paulet, R, Aubrun, F, Guerin, C, Floccard, B, Rimmele, T, Argaud, L, Hernu, R, Crozon Clauzel, J, Wey, P, Bourdin, G, Pommier, C, Cueuille, N, de Varax, N, Marchi, E, Papazian, L, Jochmans, S, Monchi, M, Jaber, S, de Jong, A, Moulaire, V, Capron, M, Jarrige, L, Barberet, G, Lakhal, K, Rozec, B, Dellamonica, J, Robert, A, Bernardin, G, Danin, P, Raucoules, M, Runge, I, Foucrier, A, Hamada, S, Tesniere, A, Fromentin, M, Samama, C, Mira, J, Diehl, J, Mekontso Dessap, A, Arbelot, C, Demoule, A, Roche, A, Similowski, T, Ricard, J, Gaudry, S, Dreyfuss, D, de Montmolin, E, da Silva, D, Verdiere, B, Ardisson, F, Lemiale, V, Azoulay, E, Bruel, C, Tiercelet, K, Fartoukh, M, Voiriot, G, Hoffmann, C, Leclerc, T, Thille, A, Robert, R, Beduneau, G, Beuzelin, M, Tamion, F, Morel, J, Tremblay, A, Molliex, S, Amal, J, Meaudre, E, Goutorbe, P, Laffon, M, Gros, A, Nica, A, Barjon, G, Dahyot-Fizelier, C, Imzi, N, Gally, J, Real, N, Sauneuf, B, Souloy, X, Girbes, A, Tuinman, P, Schultz, M, Winters, T, Mijzen, L, Roekaerts, P, Vermeijden, W, Beishuizen, A, Trof, R, Corsten, S, Kesecioglu, J, Dieperink, W, Pickers, P, Roovers, N, Duque, M, Rua, F, Pereira de Figueired, A, Ramos, A, Fragoso, E, Azevedo, P, Gouveia, J, Costa E. Silva, Z, Silva, G, Chaves, S, Nobrega, J, Lopes, L, Valerio, B, Araujo, A, de Freitas, P, Bouw, M, Melao, M, Granja, C, Marcal, P, Fernandes, A, Joao, G, Maia, D, Spadaro, S, Volta, C, Citerio, G, Mauri, T, Alban, L, Pesenti, A, Mistraletti, G, Formenti, P, Tommasino, C, Tardini, F, Fumagalli, R, Colombo, R, Fossali, T, Catena, E, Todeschini, M, Gnesin, P, Cracchiolo, A, Palma, D, Tetamo, R, Albiero, D, Costantini, E, Raimondi, F, Coppadoro, A, Vascotto, E, Lusenti, F, Schã¤dler, D, Weiler, N, Karagiannidis, C, Petersson, J, Konrad, D, Kawati, R, Wessbergh, J, Valtysson, J, Rockstroh, M, Borgstrom, S, Larsson, N, Thunberg, J, Camsooksai, J, Briggs, N, Cuesta, J, Anwar, S, Oâ€™Brien, B, Barberis, L, Sturman, J, Karatzas, S, Piza, P, Sottiaux, T, Adam, J, Gawda, R, Gawor, M, Alqdah, M, Cohen, D, Baker, A, Ã‘amendys-Silva, S, Garcia-Guillen, F, Morocho Tutillo, D, Jibaja Vega, M, Zakalik, G, Pagella, G, and Marengo, J
Subjects: ARDS, RECEIVING MECHANICAL VENTILATION, Epidemiology, medicine.medical_treatment, cross-sectional studies, RESPIRATORY-DISTRESS-SYNDROME, vrouwelijk, buikligging, Critical Care and Intensive Care Medicine, respiratory distress syndrome, adult/therapy, law.invention, Positive-Pressure Respiration, Prone position, 0302 clinical medicine, Mechanical ventilation, prospectieve studies, Randomized controlled trial, law, middle aged, Medicine, FAILURE, adult/therapy, humans, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, RANDOMIZED CONTROLLED-TRIAL, respiratory distress syndrome, 3. Good health, cross-sectionele studies, ademnoodsyndroom, aged, female, SURVIVAL, middelbare leeftijd, medicine.medical_specialty, Pain medicine, positieve druk uitademing, NO, 03 medical and health sciences, male, mensen, Anesthesiology, ouderen, METAANALYSIS, business.industry, MORTALITY, 030208 emergency & critical care medicine, mannelijk, CARE, medicine.disease, prospective studies, EVOLUTION, body regions, 030228 respiratory system, Emergency medicine, Observational study, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Introduction: While prone positioning (PP) has been shown to improve patient survival in moderate to severe acute respiratory distress syndrome (ARDS) patients, the rate of application of PP in clinical practice still appears low.Aim: This study aimed to determine the prevalence of use of PP in ARDS patients (primary endpoint), the physiological effects of PP, and the reasons for not using it (secondary endpoints).Methods: The APRONET study was a prospective international 1-day prevalence study performed four times in April, July, and October 2016 and January 2017. On each study day, investigators in each ICU had to screen every patient. For patients with ARDS, use of PP, gas exchange, ventilator settings and plateau pressure (Pplat) were recorded before and at the end of the PP session. Complications of PP and reasons for not using PP were also documented. Values are presented as median (1st-3rd quartiles).Results: Over the study period, 6723 patients were screened in 141 ICUs from 20 countries (77% of the ICUs were European), of whom 735 had ARDS and were analyzed. Overall 101 ARDS patients had at least one session of PP (13.7%), with no differences among the 4 study days. The rate of PP use was 5.9% (11/187), 10.3% (41/399) and 32.9% (49/149) in mild, moderate and severe ARDS, respectively (P = 0.0001). The duration of the first PP session was 18 (16-23) hours. Measured with the patient in the supine position before and at the end of the first PP session, PaO2/FIO2 increased from 101 (76-136) to 171 (118-220) mmHg (P = 0.0001) driving pressure decreased from 14 [11-17] to 13 [10-16] cmH(2)O (P = 0.001), and Pplat decreased from 26 [23-29] to 25 [23-28] cmH(2)O (P = 0.04). The most prevalent reason for not using PP (64.3%) was that hypoxemia was not considered sufficiently severe. Complications were reported in 12 patients (11.9%) in whom PP was used (pressure sores in five, hypoxemia in two, endotracheal tube-related in two ocular in two, and a transient increase in intracranial pressure in one).Conclusions: In conclusion, this prospective international prevalence study found that PP was used in 32.9% of patients with severe ARDS, and was associated with low complication rates, significant increase in oxygenation and a significant decrease in driving pressure.
Published: 2018

8. Blood pressure monitoring during arrhythmia: agreement between automated brachial cuff and intra-arterial measurements

Author: Lakhal, K., Ehrmann, S., Martin, M., Faiz, S., Réminiac, F., Cinotti, R., Capdevila, X., Asehnoune, K., Blanloeil, Y., Rozec, B., and Boulain, T.
Published: 2015
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9. Club 35 Poster session Friday 13 December: 13/12/2013, 08: 30–18: 00Location: Poster area

Author: Lamer, M, Cinotti, R, Delater, A, Asehnoune, K, Blanloeil, Y, Le Tourneau, T, Rozec, B, and Piriou, N
Published: 2013

10. Investigation of the different adrenoceptor targets of nebivolol enantiomers in rat thoracic aorta

Author: Tran Quang, T, Rozec, B, Audigane, L, and Gauthier, C
Published: 2009
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11. RETROSPECTIVE ANALYSIS ASSESSING ECONOMIC IMPACT OF APROTININ REINSTATEMENT IN 4 FRENCH CARDIAC SURGERY CENTRES

Author: Colson, P., Provenchere, S., Fellahi, J., Gaudard, P., and Rozec, B.
Published: 2022
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12. Is automated brachial cuff measurement of arterial pressure less accurate in cases of arrhythmia?

Author: Lakhal, K, Faiz, S, Martin, M, Crouzet, AS, Reminiac, F, Ehrmann, S, Cinotti, R, Capdevila, X, Asehnoune, K, Blanloeil, Y, Rozec, B, and Boulain, T
Published: 2013
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13. O-GLCNACYLOMIC APPROACH REVEALS ATP CITRATE LYASE AS A POTENTIAL TARGET IN SEPSIS IN THE YOUNG RAT

Author: DUPAS, T., DENIS, M., PERSELLO, A., DONTAINE, J., BULTOT, L., BETUS, C., PELÉ, T., ERRAUD, A., VERTOMMEN, D., TESSIER, A., BERTRAND, L., ROZEC, B., and LAUZIER, B.
Published: 2022
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14. The Secretome Deregulations in a Rat Model of Endotoxemic Shock.

Author: Blangy-Letheule, A., Persello, A., Michelland, S., Cunin, V., Souab, F., Aillerie, V., Dhot, J., Erraud, A., Montnach, J., Seve, M., Bourgoin-Voillard, S., Rozec, B., De Waard, M., and Lauzier, B.
Published: 2021
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15. Intracerebral hemorrhage in ICU: is it worth treating?

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Ortega, A, Forbes, C, Prescott, H, Lal, A, Khan, F, Dela Pena, E, Dizon, J, Wong, C, Garach, M, Romero, O, Puerta, R, Diaz, F, Bailon, A, Pinel, A, Maldonado, L, Kalaiselvan, M, Kumar, R, Renuka, M, De Rosa, S, Ferrari, F, Checcacci, S, Rigobello, A, Joannidis, M, Politi, F, Pellizzari, A, Bonato, R, Fernandez Carmona, A, Macias Guarasa, I, Gutierrez Rodriguez, R, Martinez Lopez, P, Diaz Castellanos, M, Arias Diaz, M, Aguilar Alonso, E, Nikandish, R, Artemenko, V, Budnyuk, A, Bassi, G, Senussi, T, Idone, F, Xiol, E, Travierso, C, Chiurazzi, C, Motos, A, Amaro, R, Hua, Y, Fernández Barat, L, Ranzani, O, Bobi, Q, Rigol, M, Youn, A, Hwang, J, Ossorio, M, Figueira, H, Oliveira, R, Mota, A, Kamp, O, Cruciger, O, Aach, M, Kaczmarek, C, Waydhas, C, Schildhauer, T, Hamsen, U, Camprubí Rimblas, M, Chimenti, L, Guillamat Prats, R, Lebouvier, T, Bringué, J, Tijero, J, Gómez, M, Blanch, L, Tagliabue, G, Ji, M, Jagers, J, Easton, P, Hong, J, Shin, M, Park, M, Pomprapa, A, Hofferberth, M, Russ, M, Braun, W, Walter, M, Francis, R, Lachmann, B, Leonhardt, S, Landaverde López, A, Canedo Castillo, N, Esquivel Chávez, A, Arvizu Tachiquín, P, Baltazar Torres, J, Cardoso, V, Krystopchuk, A, Castro, S, Melão, L, Firmino, S, Marreiros, A, Almaziad, S, Kubbara, A, Barnett, W, Nakity, R, Alamoudi, W, Altook, R, Tarazi, T, Fida, M, Safi, F, Assaly, R, Santini, A, Milesi, M, Maraffi, T, Pugni, P, Cavenago, M, Gattinoni, L, Protti, A, Perchiazzi, G, Borges, J, Bayat, S, Porra, L, Broche, L, Hedenstierna, G, Larsson, A, Roneus, A, Segelsjö, M, Vestito, M, Gremo, E, Nyberg, A, Castegren, M, Pikwer, A, Yoshida, T, Engelberts, D, Otulakowski, G, Katira, B, Post, M, Amato, M, Koch, N, Hoellthaler, J, Mair, S, Phillip, V, Beitz, A, Baladrón, V, Villarejo, P, Steenstra, R, Banierink, H, Hof, J, Hoekstra, M, Sterz, F, Horvatits, K, Herkner, H, Kott, M, Zitta, K, Brandt, B, Schildhauer, C, Elke, G, Hummitzsch, L, Albrecht, M, González, L, Alonso, D, Sánchez, R, Lucas, J, Ferlitsch, A, Fauler, G, Trauner, M, Pischke, S, Fischer, L, Thaiss, F, Koch, M, Bangert, K, Lohse, A, Nashan, B, Sterneck, M, Faenza, S, Siniscalchi, A, Pierucci, E, Mancini, E, Ricci, D, Gemelli, C, Cuoghi, A, Magnani, S, Atti, M, Sotos, F, Cánovas, J, López, A, Burruezo, A, Torres, D, Herrera Gutierrez, M, Barrueco Francioni, J, Arias Verdú, D, Lozano Saez, R, Quesada Garcia, G, Seller Pérez, G, Figueiredo, A, Anzola, Y, Pereira, R, Bento, L, Lai, M, Deiana, M, Seller Perez, G, Vardas, K, Ilia, S, Sertedaki, A, Charmadari, E, Stratakis, C, Briassouli, E, Goukos, D, Psarra, K, Botoula, E, Tsagarakis, S, Mageira, E, Routsi, C, Nanas, S, Campello, E, Radu, C, Su, H, Lam, Y, Willis, K, Pullar, V, Hubner, R, Tsang, J, de Guadiana Romualdo, L, Rebollo Acebes, S, Esteban Torrella, P, Jiménez Sánchez, R, Jiménez Santos, E, Ortín Freire, A, Hernando Holgado, A, Albaladejo Otón, M, Coelho, L, Rabello, L, Póvoa, P, Varis, E, Poukkanen, M, Jacob, S, Takala, J, Wilkman, E, Lundberg, O, Bergenzaun, L, Rydén, J, Rosenqvist, M, Melander, O, Chew, M, Kishihara, Y, Yasuda, H, Jimenez, R, Torrella, P, Fernandez, A, Sanchez, S, Ortin, A, Prats, R, Aguilera, E, Marti, D, Fernandez, L, Ferrer, M, Lanziotti, V, Pulcheri, L, Ribeiro, M, Barbosa, A, E. Silva, J, Soares, M, Marqués, M, Moreno, A, Pizarraya, A, Smani, Y, Connell, M, Zhang, L, Parker, R, Banerjee, I, Clermont, G, Norberg, E, Oras, J, Cuisinier, A, Maufrais, C, Payen, J, Nottin, S, Walther, G, Arib, S, Bilotta, F, Badenes, R, Rubulotta, F, Mirek, S, Monfort, B, Stazi, E, Roig, A, Magnoni, S, Marando, M, Pifferi, S, Conte, V, Ortolano, F, Carbonara, M, Bertani, G, Scola, E, Cadioli, M, Triulzi, F, Colombo, A, Stocchetti, N, Rotzel, H, Lázaro, A, Prada, D, Guimillo, M, Piqueras, C, Guia, J, Simon, M, Arizmendi, A, Carratalá, A, El Maraghi, S, Yehia, A, Bakry, M, Shoman, A, Backes, F, Bianchin, M, Vieira, S, de Souza, A, Backes, A, Klein, C, Arunkumar, A, Lozano, A, Gallaher, C, Cattlin, S, Gordon, S, Picard, J, Fontana, V, Bond, O, Nobile, L, Mrozek, S, Delamarre, L, Capilla, F, Al Saati, T, Fourcade, O, Dominguez Berrot, A, Gonzalez Vaquero, M, Vallejo Pascual, M, Gupta, D, Ivory, B, Chopra, M, Mccarthy, J, Felderhof, C, Macneil, C, Maggiorini, M, Duska, F, Fumis, R, Junior, J, Amarante, G, Skorko, A, Sanders, S, Aron, J, Kroll, R, Redfearn, C, Krishnan, P, Khalil, J, Kongpolprom, N, Gulia, V, Lourenço, E, Duro, C, Baptista, G, Alves, A, Arminda, B, Rodrigues, M, Hayward, J, Baldwin, F, Gray, R, Katinakis, P, Stijf, M, Ten Kleij, M, Jansen Frederiks, M, Broek, R, de Bruijne, M, Spronk, P, Sinha, K, Luney, M, Palmer, K, Keating, L, Abu Habsa, M, Bahl, R, Baskaralingam, N, Ahmad, A, Kanapeckaite, L, Bhatti, P, Glace, S, Jeyabraba, S, Lewis, H, Kostopoulos, A, Raja, M, West, A, Ely, A, Turkoglu, L, Zolfaghari, P, Baptista, J, Marques, M, Martins, P, Pimentel, J, Su, Y, Villacres, S, Stone, M, Parsikia, A, Medar, S, O'Dea, K, Porter, J, Tirlapur, N, Jonathan, J, Singh, S, Takata, M, Mcwhirter, E, Lyon, R, Hariz, M, Azmi, E, Alkhan, J, Movsisyan, V, Petrikov, S, Marutyan, Z, Aliev, I, Evdokimov, A, Antonucci, E, Merz, T, Hartmann, C, Calzia, E, Radermacher, P, Nußbaum, B, Huber Lang, M, Gröger, M, Svoren Jabalera, E, Davenport, E, Humburg, P, Knight, J, Hinds, C, Jun, I, Kim, W, Besch, G, Perrotti, A, Puyraveau, M, Baltres, M, Samain, E, Chocron, S, Pili Floury, S, Plata Menchaca, E, Sabater Riera, J, Estruch, M, Boza, E, Toscana Fernández, J, Bruguera Pellicer, E, Ordoñez Llanos, J, Pérez Fernández, X, Cavaleiro, P, Tralhão, A, Arrigo, M, Lopes, J, Lebrun, M, Cholley, B, Perezvela, J, Marinmateos, H, Rivera, J, Llorente, M, De Marcos, B, Fernandez, F, Laborda, C, Zamora, D, Delgado, J, Imperiali, C, Dastis, M, Górka, J, Górka, K, Iwaniec, T, Frołow, M, Polok, K, Fronczek, J, Kózka, M, Musiał, J, Szczeklik, W, Sileli, M, Moursia, C, Maleoglou, H, Leleki, K, Uz, Z, Ince, Y, Papatella, R, Bulent, E, De Mol, B, Vicka, V, Gineityte, D, Ringaitiene, D, Norkiene, I, Sipylaite, J, Möller, C, Thomas Rueddel, D, Vlasakov, V, Rochwerg, B, Theurer, P, Al Sibai, J, Camblor, P, Fernandez, P, Gala, J, Guisasola, J, Tamura, T, Miyajima, I, Yamashita, K, Yokoyama, M, Dalampini, E, Nastou, M, Baddour, A, Ignatiadis, A, Asteri, T, Hathorn, K, Purtle, S, Viana, M, Tonietto, T, Gross, L, Costa, V, Tavares, A, Lisboa, B, Moraes, R, Viana, L, Azevedo, M, Ceniccola, G, Pequeno, R, Holanda, T, Mendonça, V, Araújo, W, Carvalho, L, Segaran, E, Vickers, L, Brinchmann, K, Wignall, I, De Brito Ashurst, I, Del Olmo, R, Vaquerizo, C, Carreño, R, Gálvez, V, Kaminsky, G, Nieto, B, Fuentes, M, De la Torre, M, Torres, E, Alonso, A, Velayos, C, Saldaña, T, Escribá, A, Grip, J, Kölegård, R, Sundblad, P, Rooyackers, O, Naser, B, Jaziri, F, Jazia, A, Barghouth, M, Hentati, O, Skouri, W, El Euch, M, Mahfoudhi, M, Turki, S, Abdelghni, K, Abdallah, B, Maha, B, Lorente, M, Włudarczyk, A, Hałek, A, Bargouth, M, Bennasr, M, Abdelghani, K, Abdallah, T, Geenen, I, Parienti, J, Shum, H, King, H, Yan, W, Londoño, J, Cardenas, C, Pedrosa, M, Gubianas, C, Bertolin, C, Batllori, N, Sirvent, J, Mukhopadhyay, A, Chan, H, Kowitlawakul, Y, Remani, D, Leong, C, Henry, C, Puthucheary, Z, Mendsaikhan, N, Begzjav, T, Lundeg, G, Dünser, M, Welsh, S, Guerra, E, Zerpa, M, Zechner, F, Berdaguer, F, Risso Vazquez, A, Masevicius, F, Greaney, D, Magee, A, Fitzpatrick, G, Lugo Cob, R, Tejeda Huezo, B, Cano Oviedo, A, Aydogan, M, Togal, T, Taha, A, Chai, H, Kam, C, Razali, S, Sivasamy, V, Kuan, L, Morales, M, Pires, T, and Azevedo, L
Subjects: intracerebral haemorrhage in intensive care
Published: 2016

16. Effect of Xenon Anesthesia Compared to Sevoflurane and Total Intravenous Anesthesia for Coronary Artery Bypass Graft Surgery on Postoperative Cardiac Troponin Release: An International, Multicenter, Phase 3, Single-blinded, Randomized Noninferiority Trial

Author: Hofland, J., Ouattara, A., Fellahi, J.L., Gruenewald, M., Hazebroucq, J., Ecoffey, C., Joseph, P., Heringlake, M., Steib, A., Coburn, M., Amour, J., Rozec, B., Liefde, I., Meybohm, P., Preckel, B., Hanouz, J.L., Tritapepe, L., Tonner, P., Benhaoua, H., Roesner, J.P., Bein, B., Hanouz, L., Tenbrinck, R., Bogers, A., Mik, B.G., Coiffic, A., Renner, J., Steinfath, M., Francksen, H., Broch, O., Haneya, A., Schaller, M., Guinet, P., Daviet, L., Brianchon, C., Rosier, S., Lehot, J.J., Paarmann, H., Schon, J., Hanke, T., Ettel, J., Olsson, S., Klotz, S., Samet, A., Laurinenas, G., Thibaud, A., Cristinar, M., Collanges, O., Levy, F., Rossaint, R., Stevanovic, A., Schaelte, G., Stoppe, C., Hamou, N.A., Hariri, S., Quessard, A., Carillion, A., Morin, H., Silleran, J., Robert, D., Crouzet, A.S., Zacharowski, K., Reyher, C., Iken, S., Weber, N.C., Hollmann, M., Eberl, S., Carriero, G., Collacchi, D., Persio, A. Di, Fourcade, O., Bergt, S., Alms, A., APH - Quality of Care, Anesthesiology, ANS - Neuroinfection & -inflammation, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, and ACS - Atherosclerosis & ischemic syndromes
Subjects: Male, Methyl Ethers, inhalation, Internationality, Xenon, Troponin I, anesthesia, Middle Aged, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], Sevoflurane, Postoperative Complications, Treatment Outcome, anesthetics, intravenous, Anesthetics, Inhalation, Anesthesia, Intravenous, Humans, Female, Single-Blind Method, Prospective Studies, aged, anesthetics, inhalation, biomarkers, coronary artery bypass, female, humans, male, methyl ethers, middle aged, postoperative complications, prospective studies, single-blind method, treatment outcome, troponin i, xenon, anesthesia, intravenous, internationality, Coronary Artery Bypass, Biomarkers, Aged
Abstract: Item does not contain fulltext BACKGROUND: Ischemic myocardial damage accompanying coronary artery bypass graft surgery remains a clinical challenge. We investigated whether xenon anesthesia could limit myocardial damage in coronary artery bypass graft surgery patients, as has been reported for animal ischemia models. METHODS: In 17 university hospitals in France, Germany, Italy, and The Netherlands, low-risk elective, on-pump coronary artery bypass graft surgery patients were randomized to receive xenon, sevoflurane, or propofol-based total intravenous anesthesia for anesthesia maintenance. The primary outcome was the cardiac troponin I concentration in the blood 24 h postsurgery. The noninferiority margin for the mean difference in cardiac troponin I release between the xenon and sevoflurane groups was less than 0.15 ng/ml. Secondary outcomes were the safety and feasibility of xenon anesthesia. RESULTS: The first patient included at each center received xenon anesthesia for practical reasons. For all other patients, anesthesia maintenance was randomized (intention-to-treat: n = 492; per-protocol/without major protocol deviation: n = 446). Median 24-h postoperative cardiac troponin I concentrations (ng/ml [interquartile range]) were 1.14 [0.76 to 2.10] with xenon, 1.30 [0.78 to 2.67] with sevoflurane, and 1.48 [0.94 to 2.78] with total intravenous anesthesia [per-protocol]). The mean difference in cardiac troponin I release between xenon and sevoflurane was -0.09 ng/ml (95% CI, -0.30 to 0.11; per-protocol: P = 0.02). Postoperative cardiac troponin I release was significantly less with xenon than with total intravenous anesthesia (intention-to-treat: P = 0.05; per-protocol: P = 0.02). Perioperative variables and postoperative outcomes were comparable across all groups, with no safety concerns. CONCLUSIONS: In postoperative cardiac troponin I release, xenon was noninferior to sevoflurane in low-risk, on-pump coronary artery bypass graft surgery patients. Only with xenon was cardiac troponin I release less than with total intravenous anesthesia. Xenon anesthesia appeared safe and feasible.
Published: 2017

17. O-GlcNAcylation blood levels are increased in response to stress induced by cardiopulmonary bypass

Author: Ferreira, M., Persello, A., Souab, F., Gaillard, C., Denis, M., Blangy-Letheule, A., Erraud, A., Maillard, A., Dupas, T., Bigot-Corbel, E., Rozec, B., and Lauzier, B.
Published: 2021
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18. Study of secretome deregulation of a rat model of endotoxemic shock using a non-targeted mass spectrometry approach

Author: Blangy-Letheule, A., Persello, A., Michelland, S., Cunin, V., Souab, F., Aillerie, V., Dhot, J., Montnach, J., Seve, M., Bourgoin-Voillard, S., Rozec, B., De Waard, M., and Lauzier, B.
Published: 2021
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19. O-GlcNAc stimulation is beneficial in sepsis in the young rat, involvement of the ATP-citrate lyase

Author: Dupas, T., Denis, M., Persello, A., Dontaine, J., Bultot, L., Erraud, A., Dhot, J., Pelé, T., Leroux, A., Bigot-Corbel, E., Montnach, J., Vertommen, D., Lebreton, J., Tessier, A., Rivière, M., De Waard, M., Bertrand, L., Rozec, B., and Lauzier, B.
Published: 2021
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20. Post-natal activity of cardiac O-GlcNAcase is regulated to maintain physiological levels of O-GlcNAc

Author: Betus, C., Dupas, T., Denis, M., Persello, A., Erraud, A., Pele, T., Ferreira, M., Leroux, A.A., Lebreton, J., Tessier, A., De Waard, M., Rozec, B., and Lauzier, B.
Published: 2021
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21. O-GlcNAc levels stimulation improves survival at the early phase of septic shock in the young

Author: Dupas, T., Denis, M., Persello, A., Erraud, A., Bigot-Corbel, E., Lebreton, J., Tessier, A., De Waard, M., Gauthier, C., Rozec, B., and Lauzier, B.
Published: 2021
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22. Assessment of nutritional status by monitoring quadriceps muscle layer thickness with ultrasonography in intensive care unit: an observational study

Author: Brisard, L., Lakhal, K., Le Thuaut, A., Fresco, M., Nicolet, J., Lepoivre, T., Demeure dit Latte, D., Cinotti, R., Zambon, O., Nicolet, L., Asehnoune, K., Reigner, J., and Rozec, B.
Published: 2020
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23. Deciphering cardiac O-GlcNAcylation: A new perspective of cardiac mitochondrial regulation

Author: Persello, A., Denis, M., Dupas, T., Dontaine, J., Bultot, L., Erraud, A., Vertommen, D., Dhot, J., De Waard, M., Rozec, B., Bertrand, L., Burelle, Y., and Lauzier, B.
Published: 2020
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24. A non-targeted quantitative mass spectrometry approach for the identification of new blood biomarkers of septic shock in the secretory of a rat model of endotoxemic shock

Author: Bangy-Letheule, A., Souab, F., Bourgoin, S., Michelland, S., Cunin, V., Seve, M., Aillerie, V., Dhot, J., Montnach, J., Persello, A., Rozec, B., Lauzier, B., and De Waard, M.
Published: 2020
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25. Integrated stress response activation after recovery of cardiopulmonary bypass in rats

Author: Persello, A., Aillerie, V., Erraud, A., Miniou, P., Guedat, P., De Waard, M., Gauthier, C., Abgueguen, E., Rozec, B., and Lauzier, B.
Published: 2020
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26. O-GlcNAc levels are regulated in a tissue and time specific manner during post-natal development, independently of dietary intake

Author: Dupas, T., Denis, M., Dontaine, J., Persello, A., Bultot, L., Erraud, A., Vertommen, D., Bouchard, B., Dhot, J., De Waard, M., Olson, A., Rozec, B., Rosiers, C. Des, Bertrand, L., Issad, T., and Lauzier, B.
Published: 2020
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27. Effect of β3-adrenergic receptor modulation on endothelial function

Author: Dhot, J., Persello, A., Burban, M., Stevant, D., Aillerie, V., Erraud, A., Tesse, A., De Waard, M., Rozec, B., Gauthier, C., and Lauzier, B.
Published: 2020
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28. Cardiac O-GlcNAc levels variation with age: Impact of suckling to weaning transition

Author: Dupas, T., Denis, M., Dontaine, J., Bultot, L., Persello, A., Erraud, A., Vertommen, D., Rozec, B., Bertrand, L., Issad, T., and Lauzier, B.
Published: 2020
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29. ESICM LIVES 2016: part two

Author: Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. V., Tsvetanova-Spasova, T., Nuevo-Ortega, P., Rueda-Molina, C., Fernández-Porcel, A., Camara-Sola, E., Salido-Díaz, L., García-Alcántara, A., Meleti, D. E., Suberviola, B., Riera, J., Rellan, L., Sanchez, M., Robles, J. C., Lopez, E., Vicente, R., Miñambres, E., Santibañez, M., Le Guen, M., Moore, J., Mason, N., Windpassinger, M., Plattner, O., Mascha, E., Sessler, D. I., Research, Outcomes, Melia, U., Fontanet, J., van den Berg, J. P., Struys, M. M. R. F., Vereecke, H. E. M., Jensen, E. W., Rood, P. J. T., van de Schoor, F., van Tertholen, K., Pickkers, P., van den Boogaard, M., Beardow, Z. J., Redhead, H., Paramasivam, K., Numan, T., Kamper, A. M., Rood, P., Peelen, L. M., Zeman, P. M., Slooter, A. J., van Ewijk, C. E., Jacobs, G. E., Girbes, A. R. J., Myatra, S. N., Harish, M. M., Prabu, N. R., Siddiqui, S., Kulkarni, A. P., Divatia, J. V., Murbach, L. D., Leite, M. A., Osaku, E. F., Costa, C. R. L. M., Pelenz, M., Neitzke, N. M., Moraes, M. M., Jaskowiak, J. L., Silva, M. M. M., Zaponi, R. S., Abentroth, L. R. L., Ogasawara, S. M., Jorge, A. C., Duarte, P. A. D., Hernández-Sánchez, N., Sánchez-Hurtado, L. A., García-Guillen, F. J., Ñamendys-Silva, S. A., Maghsoudi, B., Emami, M., Khosravi, M. B., Zand, F., Tabatabaie, H. R., Masjedi, M., Sabetiyan, G., Mokri, A., Troubleyn, J., Diltoer, M., Jacobs, R., Nguyen, D. N., De Waele, E., De Regt, J., Honoré, P. M., Van Gorp, V., Spapen, H. D., Contreras, R. S., Toapanta, N. D., Moreno, G., Sabater, J., Torrado, H., Gonzalez, M., Marin, M., Farigola, E., Gonzalez, A., Fernandez, J., Vera, A., Gisbert, X., Juliá, C., Uya, J., Corral, L., Elias-Jones, I., Gemmell, L., MacKay, A., Randall, D., Adwaney, A., Blunden, M., Prowle, J. R., Kirwan, C. J., Thomas, N., Martin, A., Owen, H., Darwin, L., Conway, D., Atkinson, D., Sharman, M., Barbanti, C., Amour, J., Gaudard, P., Rozec, B., Mauriat, P., M’rini, M., Leger, P. L., Cambonie, G., Liet, J. M., Girard, C., Laroche, S., Damas, P., Assaf, Z., Loron, G., Lecourt, L., Pouard, P., Prowle, J.R., Kim, S. H., Na, S., Kim, J., Oh, S. Y., Jung, C. W., Yoo, S. H., Min, S. H., Chung, E. J., Lee, H., Lee, N. J., Lee, K. W., Suh, K. S., Ryu, H. G., Marshall, D. C., Goodson, R. J., Salciccioli, J. D., Shalhoub, J., Potter, E. K., Kirk-Bayley, J., Karanjia, N. D., Forni, L. G., Creagh-Brown, B. C., Bossy, M., Nyman, M., Tailor, A., Creagh-Brown, B., D’Antini, D., Spadaro, S., Valentino, F., Sollitto, F., Cinnella, G., Mirabella, L., Calvo, F. J. Redondo, Bejarano, N., Padilla, D., Baladron, V., Villajero, P., Villazala, R., Redondo, J., Yuste, A. S., Liu, J., Shen, F., Teboul, J. L., Anguel, N., Beurton, A., Bezaz, N., Richard, C., Monnet, X., Fossali, T., Colombo, R., Ottolina, D., Rossetti, M., Mazzucco, C., Marchi, A., Porta, A., Catena, E., Tollisen, K. H., Andersen, G. Ø., Heyerdahl, F., Jacobsen, D., de Waard, M. C., van IJzendoorn, M. C. O., Buter, H., Kingma, W. P., Navis, G. J., Boerma, E. C., Rulisek, J., Balik, M., Zacharov, S., Kim, H. S., Jeon, S. J., Namgung, H., Lee, E., Cho, Y. J., Lee, Y. J., Huang, A., Cioccari, L., Luethi, N., Mårtensson, J., Bellomo, R., Forsberg, M., Edman, G., Höjer, J., Forsberg, S., Freile, M. T. Chiquito, Hidalgo, F. N., Molina, J. A. Martinez, Lecumberri, R., Rosselló, A. Figuerola, Travieso, P. Medrano, Leon, G. Tuero, Sanchez, J. Gonzalez, Frias, L. Sahuquillo, Rosello, D. Balsells, Verdejo, J. A. Garcia, Serrano, J. A. Noria, Winterwerp, D., van Galen, T., Vazin, A., Karimzade, I., Zand, A., Ozen, E., Ekemen, S., Akcan, A., Sen, E., Yelken, B. Buyukkidan, Kureshi, N., Fenerty, L., Thibault-Halman, G., Erdogan, M., Walling, S., Green, R. S., Clarke, D. B., Briassoulis, P., Kalimeris, K., Ntzouvani, A., Nomikos, T., Papaparaskeva, K., Politi, E., Kostopanagiotou, G., Crewdson, K., Rehn, M., Weaver, A., Brohi, K., Lockey, D., Wright, S., Thomas, K., Baker, C., Mansfield, L., Stafford, V., Wade, C., Watson, G., Bryant, A., Chadwick, T., Shen, J., Wilkinson, J., Furneval, J., Henderson, A., Hugill, K., Howard, P., Roy, A., Bonner, S., Baudouin, S., Ramírez, C. Sánchez, Escalada, S. Hípola, Viera, M. A. Hernández, Santana, M. Cabrera, Balcázar, L. Caipe, Monroy, N. Sangil, Campelo, F. Artiles, Vázquez, C. F. Lübbe, Santana, P. Saavedra, Santana, S. Ruiz, Quintard, H., Bouzat, P., Wollersheim, T., Malleike, J., Haas, K., Carbon, N., Schneider, J., Birchmeier, C., Fielitz, J., Spuler, S., Weber-Carstens, S., Enseñat, L., Pérez-Madrigal, A., Saludes, P., Proença, L., Gruartmoner, G., Espinal, C., Mesquida, J., Huber, W., Eckmann, M., Elkmann, F., Gruber, A., Lahmer, T., Mayr, U., Herner, A., Schellnegger, R., Schmid, R. M., Ayoub, W., Samy, W., Esmat, A., Battah, A., Mukhtar, S., Mongkolpun, W., Cortés, D. Orbegozo, Cordeiro, C. P. R., Funcke, S., Groesdonk, H., Saugel, B., Wagenpfeil, G., Wagenpfeil, S., Reuter, D. A., Fernandez, M. M., Fernandez, R., Magret, M., González-Castro, A., Bouza, M. T., Ibañez, M., García, C., Balerdi, B., Mas, A., Arauzo, V., Añón, J. M., Ruiz, F., Ferreres, J., Tomás, R., Alabert, M., Tizón, A. I., Altaba, S., Llamas, N., Goligher, E C., Fan, E., Herridge, M., Vorona, S., Sklar, M., Dres, M., Rittayamai, N., Lanys, A., Urrea, C., Tomlinson, G., Reid, W. D., Rubenfeld, G. D., Kavanagh, B. P., Brochard, L. J., Ferguson, N. D., Neto, A. Serpa, de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Guérin, C., Papazian, L., Reignier, J., Ayzac, L., Loundou, A., Forel, J. M., Rolland-Debord, C., Bureau, C., Poitou, T., Clavel, M., Perbet, S., Terzi, N., Kouatchet, A., Similowski, T., Demoule, A., Hunfeld, N., Trogrlic, Z., Ladage, S., Osse, R. J., Koch, B., Rietdijk, W., Devlin, J., van der Jagt, M., Picetti, E., Ceccarelli, P., Mensi, F., Malchiodi, L., Risolo, S., Rossi, I., Antonini, M. V., Servadei, F., Caspani, M. L., Roquilly, A., Lasocki, S., Seguin, P., Geeraerts, T., Perrigault, P. F., Dahyot-Fizelier, C., Paugam-Burtz, C., Cook, F., Cinotti, R., dit Latte, D. Demeure, Mahe, P. J., Fortuit, C., Feuillet, F., Asehnoune, K., Marzorati, C., Spina, S., Scaravilli, V., Vargiolu, A., Riva, M., Giussani, C., Sganzerla, E., Citerio, G., Barbadillo, S., de Molina, F. J. González, Álvarez-Lerma, F., Rodríguez, A., Zakharkina, T., Martin-Loeches, I., Matamoros, S., Povoa, P., Torres, A., Kastelijn, J., Hofstra, J. J., de Jong, M., Schultz, M., Sterk, P., Artigas, A., Bos, L. J., Moreau, A. S., Salluh, J., Rodriguez, A., Nseir, S., de Jong, E., van Oers, J. A., Nijsten, M. W. N., de Lange, D. W., Bonvicini, D., Labate, D., Benacchio, L., Olivieri, A., Pizzirani, E., Lopez-Delgado, J. C., Gonzalez-Romero, M., Fuentes-Mila, V., Berbel-Franco, D., Romera-Peregrina, I., Martinez-Pascual, A., Perez-Sanchez, J., Abellan-Lencina, R., Ávila-Espinoza, R. E., Moreno-Gonzalez, G., Sbraga, F., Griffiths, S., Grocott, M. P. W., Doyle, J., Wilkerson, P., Soon, Y., Huddart, S., Dickinson, M., Riga, A., Zuleika, A., Miyamoto, K., Kawazoe, Y., Morimoto, T., Yamamoto, T., Fuke, A., Hashimoto, A., Koami, H., Beppu, S., Katayama, Y., Ito, M., Ohta, Y., Yamamura, H., Rygård, S. L., Holst, L B., Wetterslev, J., Johansson, P. I., Perner, A., Soliman, I. W., van Dijk, D., van Delden, J. J. M., Cremer, O. L., Slooter, A. J. C., McWilliams, D., Snelson, C., Neves, A. Das, Loudet, C. I., Busico, M., Vazquez, D., Villalba, D., Veronesi, M., Lischinsky, A., López, F. J. L., Mori, L. Benito, Plotnikow, G., Díaz, A., Giannasi, S., Hernandez, R., Krzisnik, L., Cecotti, C., Viola, L., Lopez, R., Sottile, J. P., Benavent, G., Estenssoro, E., Chen, C. M., Lai, C. C., Cheng, K. C., Chou, W., Chan, K. S., Roeker, L. E., Horkan, C. M., Gibbons, F. K., Christopher, K. B., Weijs, P. J. M., Mogensen, K. M., Rawn, J. D., Robinson, M. K., Tang, Z., Qiu, C., Ouyang, B., Cai, C., Guan, X., Regueira, T., Cea, L., Carlos, S. Juan, Elisa, B., Puebla, C., Vargas, A., Poulsen, M. K., Thomsen, L. P., Kjærgaard, S., Rees, S. E., Karbing, D. S., Frank, S., Müller, M. C., Carbon, N. M., Skrypnikov, V., Pickerodt, P. A., Falk, R., Mahlau, A., Lee, A., Inglis, R., Morgan, R., Barker, G., Kamata, K., Abe, T., Saitoh, D., Tokuda, Y., Butler, M. B., Hwa, H. Tae, Gil, L. Jae, Vaquero, R. Hernández, Rodriguez-Ruiz, E., Lago, A. Lopez, Allut, J. L. Garcia, Gestal, A. Estany, Gonzalez, M. A. Garcia, Thomas-Rüddel, D. O., Schwarzkopf, D., Fleischmann, C., Reinhart, K., Suwanpasu, S., Sattayasomboon, Y., Filho, N. M. Filgueiras, Oliveira, J. C. A., Ballalai, C. S., De Lucia, C. V., Araponga, G. P., Veiga, L. N., Silva, C. S., Garrido, M. E., Ramos, B. B., Ricaldi, E. F., Gomes, S. S., Wright, C., Docking, R. I., Doherty, P., Black, E., Stenhouse, P., Plummer, M. P., Finnis, M. E., Phillips, L. K., Kar, P., Bihari, S., Biradar, V., Moodie, S., Horowitz, M., Shaw, J. E., Deane, A. M., Yatabe, T., Inoue, S., Sakaguchi, M., Egi, M., Abdelhamid, Y. Ali, Hokka, M., Mizobuchi, S., Plummer, M., Giersch, E., Summers, M., Hatzinikolas, S., Heller, S., Jones, K., Schweizer, R., Jacquet-Lagreze, M., Portran, P., Junot, S., Allaouchiche, B., Fellahi, J. L., Guerci, P., Ergin, B., Kapucu, A., Ince, C., Crisman, M., Shinotsuka, C. Righy, Fagnoul, D., Orbegozo, D., Preiser, J. C., Thooft, A., Brimioulle, S., Iwasaka, H., Tahara, S., Nagamine, M., Ichigatani, A., Cabrera, A. Rugerio, Zepeda, E. Monares, Granillo, J. Franco, Sánchez, J. S. Aguirre, Montoya, A. A. Tanaka, Montenegro, A. Pedraza, Blanco, G. A. Gálvez, Robles, C. M. Coronado, Drolz, A., Horvatits, T., Roedl, K., Rutter, K., Funk, G. C., Schneeweiss, B., Fuhrmann, V., Sabetian, G., Pooresmaeel, F., Ghaffaripour, S., Farbod, A., Tabei, H., Taheri, L., Anandanadesan, R., Metaxa, V., Teixeira, C., Pereira, S. M., Hernández-Marrero, P., Carvalho, A. S., Beckmann, M., Hartog, C. S., Raadts, A., Robertsen, A., Førde, R., Skaga, N. O., Helseth, E., Honeybul, S., Ho, K., Lopez, P. Martinez, Gonzalez, M. Nieto, Ortega, P. Nuevo, Sola, E. Camara, Spasova, T., Kopecky, O., Rusinova, K., Waldauf, P., Cepeplikova, Z., Domínguez, J. Palamidessi, Almudevar, P. Matia, Carmona, S. Alcántara, Muñoz, J. J. Rubio, Castañeda, D. Palacios, Abellán, A. Naharro, Villamizar, P. Rodríguez, Ramos, J. Veganzones, Pérez, L. Pérez, Lucendo, A. Pérez, Ejarque, M. Camós, Estella, A., Camps, V. Lopez, Martín, M. C., Masnou, N., Barbosa, S., Varela, A., Palma, I., Cristina, L., Nunes, E., Pereira, I., Campello, G., Granja, C., Pande, R., Pandey, M., Varghese, S., Chanu, M., Van Dam, M. J., Ter Braak, E. W. M. T., Gracia, M., Viciana, R., Recuerda, M., Fontaiña, L. Perez, Tharmalingam, B., Kovari, F., Rose, L., Mcginlay, M., Amin, R., Burns, K., Connolly, B., Hart, N., Jouvet, P., Katz, S., Leasa, D., Mawdsley, C., Mcauley, D., Blackwood, B., Denham, S., Worrall, R., Arshad, M., Isherwood, P., Khadjibaev, A., Sabirov, D., Rosstalnaya, A., Parpibaev, F., Sharipova, V., Blanco, G. A. Galvez, Guzman, C. I. Olvera, Cha, Y. S., Lee, S. J., Tyagi, N., Rajput, R. K., Taneja, S., Singh, V. K., Sharma, S. C., Mittal, S., Rao, B. K., Ayachi, J., Fraj, N., Romdhani, S., Khedher, A., Meddeb, K., Sma, N., Azouzi, A., Bouneb, R., Chouchene, I., El Ghardallou, M., Boussarsar, M., Jennings, R., Walter, E., Ribeiro, J. M., Moniz, I., Marçal, R., Santos, A. C., Candeias, C., e Silva, Z. Costa, Gomez, S. E. Zamora, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Cuellar, A. I. Vasquez, Mildh, H., Pettilä, V., Korhonen, A. M., Karlsson, S., Ala-Kokko, T., Reinikainen, M., Vaara, S. T., Zaleska-Kociecka, M., Grabowski, M., Dąbrowski, M., Wozniak, S., Piotrowska, K., Banaszewski, M., Imiela, J., Stepinska, J., Pérez, A. González, Ordoñez, P. Florez, Giribet, A., Cuervo, M. A. Alonso, Cuervo, R. Alonso, Esteban, M. A. Rodriguez, Fraile, L. Iglesias, Mittelbrum, C. Ponte, Albaiceta, G. Muñiz, Koeze, J., Keus, F., Dieperink, W., van der Horst, I. C. C., van Meurs, M., Zijlstra, J. G., Roberts, S., Caballero, C. Hernandez, Isgro, G., Hall, D., Beitland, S., Trøseid, A.-M. S., Brusletto, B. S., Waldum-Grevbo, B. E., Berg, J. P., Sunde, K., Huertas, D. García, Manzano, F., Quintana, M. M. Jiménez, Osuna, A., Santiago-Ruiz, F., Rodríguez-Mejías, C., Wangensteen, R., Jamaati, H. R., Hashemian, S. M. R., Abbasi, G., Khaloo, V., Tabei, S. H.a., Kafilzadeh, A., Bakhodaei, H. Haddad, Diaz, J. A., Silva, R., Garcia, D. J., Luis, E., Gomez, M. N., Soriano, R., Gonzalez, P. L., Ibrahim, I. A., Rafik, M. M., Al-Ansary, A. M., Algendi, M. A., Ali, A. A., Benten, D., Kluwe, J., Siedler, S., Adedugbe, I., Bird, G. T., Kennedy, R. M., Sharma, S., Yugi, G., Haroon, B. A., Witter, T., Khaliq, W., Singer, M., Havaldar, A. A., Krishna, B., Sriram, S., Espinoza, E. D. Valenzuela, Pozo, M. O., Edul, V. S. Kanoore, Furche, M., Motta, M. F., Vazquez, A. Risso, Birri, P. N. Rubatto, Dubin, A., Dogliotti, A., Ramos, A., Lovesio, C., Delile, E., Nevière, R., Thiébaut, P.-A., Maupoint, J., Mulder, P., Coquerel, D., Renet, S., do Rego, J. C., Rieusset, J., Richard, V., Tamion, F., Andreis, D. T., Smit, B., Smulders, Y. M., van Straaten, H. M. Oudemans, Eringa, E. C., Man, A. M. E. Spoelstra-de, Alegría, L., Soto, D., Luengo, C., Gomez, J., Jarufe, N., Bruhn, A., Castro, R., Kattan, E., Tapia, P., Rebolledo, R., Achurra, P., Ospina-Tascón, G., Bakker, J., Hernández, G., Bertini, P., Guarracino, F., Baldassarri, R., Pinsky, M. R., Vera, M., Dreyse, J., Carpio, D., Henriquez, C., Gajardo, D., Bravo, S., Kim, S., Lee, M., Park, S. Y., So, S., Kačar, M. B., Kačar, S. M., Uddin, I., Belhaj, A. M., Aydın, M. A., Avsec, D., Kapuağası, A., Kaymak, Ç., Kovach, L., Şencan, İ., Meço, B., Özçelik, M., Ünal, N., Jenni-Moser, B., Jeitziner, M.-M., Galassi, M. S., Sales, F. L., de Moraes, K. C. L., Batista, C. L., Júnior, J. A. de Souza, Marcari, T. B., Lobato, R., Castro, C. S. A. A., de Souza, L. M., Rodrigues, F. F. P., Correa, N. G., Pelegrini, A. M., Eid, R. A. C., Timenetsky, K. T., Cazati, D., Lobato, M., Diniz, P. S., Rocha, L. L., Cavalheiro, A. M., Lucinio, N. M., Santos, E. R., Norrenberg, M., Gleize, A., Simón, I. Fernández, Valhonrat, I. Lipperheide, Almudévar, P. Matía, Dávila, F., Rubio, J. J., Ramos, A. J., Reina, Á. J. Roldán, López, N. Palomo, Pérez, M. Adriaensens, Apolo, D. X. Cuenca, Villén, L. Martín, López, F. M. Porras, García, I. Palacios, Izurieta, J. R. Naranjo, Guerrero, J. J. Egea, Calvert, S., Quint, M., Adeniji, K., Young, R., Shevill, D. D., Robertson, E., Garside, P., Isotti, P., De Vecchi, M. M., Perduca, A. E., Negro, A., Villa, G., Manara, D. F., Cabrini, L., Zangrillo, A., Frencken, J. F., van Baal, L., Donker, D. W., Horn, J., van der Poll, T., van Klei, W. A., Bonten, M. J. M., Menard, C. E., Kumar, A., Rimmer, E., Doucette, S., Turgeon, A. F., Houston, B. L., Houston, D. S., Zarychanski, R., Pinto, B. Bollen, Carrara, M., Ferrario, M., Bendjelid, K., Nunes, J., Diaz, P., Silva, G., Escórcio, S., Chaves, S., Jardim, M., Fernandes, N., Câmara, M., Duarte, R., Pereira, C. A., Vieira, J., Nóbrega, J. J., de Oca-Sandoval, M. A. Montes, Sánchez-Rodríguez, A., Joya-Galeana, J. G., Correa-Morales, A., Camarena-Alejo, G., Aguirre-Sánchez, J., Franco-Granillo, J., Soliman, M., Al Azab, A., El Hossainy, R., Nagy, H., Nirmalan, M., Crippa, I. A., Cavicchi, F. Zama, Chaari, A., Hakim, K. Abdel, Hassanein, H., Etman, M., El Bahr, M., Bousselmi, K., Khalil, E. S., Kauts, V., Casey, W. F., Imahase, H., Sakamoto, Y., Yamada, K. C., Miike, T., Nagashima, F., Iwamura, T., Boscolo, A., Lucchetta, V., Piasentini, E., Bertini, D., Manesso, L., Spiezia, L., Simioni, P., Ori, C., Souza, R. B., Martins, A. M., Liberatore, A. M. A., Kang, Y. R., Nakamae, M. N., Vieira, J. C. F., Koh, I. H. J., Hanslin, K., Wilske, F., Skorup, P., Sjölin, J., Lipcsey, M., Long, W. Jin, Zhen, C. Er, Vakalos, A., Avramidis, V., Wu, S. H., Shyu, L. J., Li, C. H., Yu, C. H., Chen, H. C., Wang, C. H., Lin, K. H., Aray, Z. E., Gómez, C. F., Tejero, A. P., Monge, D. D., Losada, V. M., Tarancón, C. M., Cortés, S. D., Gutiérrez, A. M., Álvarez, T. P., Rouze, A., Jaffal, K., Six, S., Stolz, K., Cattoen, V., Arnal, J. M., Saoli, M., Novotni, D., Garnero, A., Becher, T., Buchholz, V., Schädler, D., Frerichs, I., Weiler, N., Eronia, N., Mauri, T., Gatti, S., Maffezzini, E., Bronco, A., Alban, L., Sasso, T., Marenghi, C., Grasselli, G., Pesenti, A., Bellani, G., Al-Fares, A., Del Sorbo, L., Anwar, S., Facchin, F., Azad, S., Zamel, R., Ferguson, N., Cypel, M., Keshavjee, S., Durlinger, E., Spoelstra-de Man, A., de Grooth, H. J., Girbes, A., Straaten, H. Oudemans-van, Smulders, Y., Alfaro, M. A., Parrilla, F., Meli, A., Pellegrini, M., Rodriguez, N., Goyeneche, J. M., Morán, I., Aguirre, H., Mancebo, J., Heines, S. J. H., Strauch, U., Bergmans, D. C. J. J., Blankman, P., Shono, A., Hasan, D., Gommers, D., Chung, W. Y., Lee, K. S., Jung, Y. J., Park, J. H., Sheen, S. S., Park, K. J., Worral, R., Larraza, S., Dey, N., Brohus, J. B., Winding, R. W., Volta, C. A., Ampatzidou, F., Vlachou, A., Kehagioglou, G., Karaiskos, T., Madesis, A., Mauromanolis, C., Michail, N., Drossos, G., Saraj, N., Rijkenberg, S., Feijen, H. M., Endeman, H., Donnelly, A. A. J., Morgan, E., Garrard, H., Buckley, H., Russell, L., Haase, N., Goh, C., Mouyis, K., Woodward, C. L. N., Halliday, J., Encina, G. B., Ros, J., Lagunes, L., Tabernero, J., Bosch, F., Rello, J., Morente-Constantin, E., Rivera-Ginés, B., Colmenero-Ruiz, M., Sanz, J. García, Simon, I. Fernandez, Valbuena, B. Lobo, Carmona, S. Alcantara, Pais, M., Ramalingam, S., Díaz, C., Fox, L., Santafe, M., Barba, P., García, M., Leal, S., Pérez, M., Pérez, M. L. Pérez, Veganzones, J., Simón, I. Fernandez, Martínez, N., Moors, I., Mokart, D., Pène, F., Lambert, J., Mayaux, J., Vincent, F., Nyunga, M., Bruneel, F., Laisne, L., Rabbat, A., Lebert, C., Perez, P., Chaize, M., Renault, A., Meert, A. 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W., Hoekstra, M., Sterz, F., Horvatits, K., Herkner, H., Kott, M., Zitta, K., Brandt, B., Schildhauer, C., Elke, G., Hummitzsch, L., Albrecht, M., González, L. Rey, Alonso, D. Cabestrero, Sánchez, R. de Pablo, Lucas, J. Higuera, Ferlitsch, A., Fauler, G., Trauner, M., Pischke, S., Fischer, L., Thaiss, F., Koch, M., Bangert, K., Lohse, A. W., Nashan, B., Sterneck, M., Faenza, S., Siniscalchi, A., Pierucci, E., Mancini, E., Ricci, D., Gemelli, C., Cuoghi, A., Magnani, S., Atti, M., Sotos, F., Cánovas, J., López, A., Burruezo, A., Torres, D., Herrera-Gutierrez, M. E., Barrueco-Francioni, J., Arias-Verdú, D., Lozano-Saez, R., Quesada-Garcia, G., Seller-Pérez, G., Figueiredo, A., Anzola, Y., Pereira, R., Bento, L., Lai, M., Deiana, M., Seller-Perez, G., Vardas, K., Ilia, S., Sertedaki, A., Charmadari, E., Stratakis, C. A., Briassouli, E., Goukos, D., Psarra, K., Botoula, E., Tsagarakis, S., Mageira, E., Routsi, C., Nanas, S., Campello, E., Radu, C. M., Su, H., Lam, Y. M., Willis, K., Pullar, V., Hubner, R. P., Tsang, J. L., de Guadiana-Romualdo, L. García, Rebollo-Acebes, S., Esteban-Torrella, P., Jiménez-Sánchez, R., Jiménez-Santos, E., Ortín-Freire, A., Hernando-Holgado, A., Albaladejo-Otón, M. D., Coelho, L., Rabello, L., Póvoa, P., Varis, E., Poukkanen, M., Jacob, S., Takala, J., Wilkman, E., Lundberg, O. H. M., Bergenzaun, L., Rydén, J., Rosenqvist, M., Melander, O., Chew, M. S., Kishihara, Y., Yasuda, H., Jimenez, R., Torrella, P. Esteban, Fernandez, A., Sanchez, S., Ortin, A., Prats, R. Guillamat, Aguilera, E., Marti, D., Fernandez, L., Ferrer, M., Lanziotti, V. S., Pulcheri, L., Ribeiro, M. O., Barbosa, A. P., e Silva, J. R. Lapa, Soares, M., Salluh, J. I. F., Marqués, M. Gil, Moreno, A. Puppo, Pizarraya, A. Gutierrez, Diaz, J. Pachón, Smani, Y., Connell, M. Mc, Zhang, L. A., Parker, R. S., Banerjee, I., Clermont, G., Norberg, E., Oras, J., Cuisinier, A., Maufrais, C., Payen, J. F., Nottin, S., Walther, G., Arib, S., Bilotta, F., Badenes, R., Rubulotta, F., Mirek, S., Monfort, B., Stazi, E., Roig, A. Lozano, Magnoni, S., Marando, M., Pifferi, S., Conte, V., Ortolano, F., Carbonara, M., Bertani, G., Scola, E., Cadioli, M., Triulzi, F., Colombo, A., Stocchetti, N., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Guimillo, M. Rodriguez, Piqueras, C. Sanchís, Guia, J. Romero, Simon, M. García, Arizmendi, A. Mesejo, Carratalá, A., El Maraghi, S., Yehia, A., Bakry, M., Shoman, A., Backes, F. N., Bianchin, M. M., Vieira, S. R. R., de Souza, A., Backes, A. N., Klein, C., Arunkumar, A. S., Lozano, A., Gallaher, C., Cattlin, S., Gordon, S., Picard, J., Fontana, V., Bond, O., Nobile, L., Mrozek, S., Delamarre, L., Capilla, F., Al-Saati, T., Fourcade, O., Dominguez-Berrot, A. M., Gonzalez-Vaquero, M., Vallejo-Pascual, M. E., Gupta, D., Ivory, B. D., Chopra, M., McCarthy, J., Felderhof, C. L., MacNeil, C., Maggiorini, M., Duska, F., Fumis, R. R. L., Junior, J. M. 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Subjects: Meeting Abstracts
Abstract: Introduction In addition to systemic hemodynamics, the management\ud of neurocritically ill patients is often informed by neuromonitoring. In\ud the absence of high-level evidence clinicians are often guided by personal\ud and local expertise. Little is known about practices as they pertain\ud to the use of such monitoring in patients with acute brain injury (ABI).\ud Objectives To investigate practices in bedside monitoring for ABI patients.\ud Particularly interested in differences among “neurointensivists”\ud (NIs; defined here as intensivists whose clinical practice is comprised\ud > 1/3 by neurocritical care) and other intensivists (OIs). Also, to\ud explore patterns specific to traumatic brain injury (TBI) and subarachnoid\ud hemorrhage (SAH), as well as preferences and availability of\ud particular technologies/devices.\ud Methods Electronic survey of 22 items including two case-based scenarios;\ud endorsed by SCCM (9,000 recipients) and ESICM (on-line\ud newsletter) in 2013. A sample size of 370 was calculated based on a\ud population of 10,000 physician members, a 5 % margin error, and\ud 95 % confidence interval. We summarized results using descriptive\ud statistics (proportions with 95 % confidence intervals). A chi-square\ud test was used to compare proportions of responses between NIs and\ud OIs with a significance p < 0.05.\ud Results There were 655 responders (66 % completion rate); 422(65 %)\ud were classified as OIs and 226(35 %) as NIs. More NIs follow\ud hemodynamic protocols for neurocritically-ill patients (56 % vs. 43 %, p\ud 0.001), in TBI (44.5 % vs. 33.3 %, p 0.007), and in SAH (38.1 % vs. 21.3 %,\ud p < 000.1). For delayed cerebral ischemia (DCI), more NIs target cardiac\ud index (CI) (35 % vs. 21 %, p 0.0001), and fluid responsiveness (62 % vs.\ud 53 %, p 0.03), use more bedside ultrasound (BUS) (42 % vs. 29 %, p\ud 0.005) and arterial waveform analysis (40 % vs. 29 %, p 0.02). For DCI\ud neuromonitoring, NIs use more angiography (57 % vs. 43 %, p 0.004),\ud TCD (46 % vs. 38 %, p 0.0001), and CTP (32 % vs.16 %, p 0.0001). For\ud CPP optimization in TBI, NIs use more arterial waveform analysis (45 %\ud vs. 35 %, p 0.019), and BUS (37 % vs. 27.7 %, p 0.023), while more OIs\ud monitor mixed venous oxygen saturation (54.1 % vs. 45 %, p 0.045). For\ud TBI neuromonitoring, NIs use more PbtO2 (28 % vs. 10 %, p 0.0001). In\ud the case scenario of raised ICP/low PbtO2, most employ analgosedation\ud (47 %) and osmotherapy (38 %). Fewer make use of preserved pressure\ud reactivity, particularly OIs (vasopressor use 23 % vs. 34 %, p 0.014).\ud Conclusions There is large heterogeneity in the use of monitoring protocols,\ud variables, and technologies/devices. “Neurointensivists” not only\ud employ more neuromonitoring but also more hemodynamic monitoring\ud in patients with acute brain injury. ICP/CPP remain the most commonly\ud followed neuro-variables in TBI patients, with low use of other\ud brain-physiology parameters, sugg
Published: 2016

30. SECONDARY REACTIVE OXYGEN SPECIES PRODUCTION IN SERA OF PATIENTS WITH RESPECTABLE NON-SQUAMOUS CELL LUNG CANCERS

Author: PATRICE, Thierry, ROZEC, B., SIDOROFF, A., BLANLOEIL, Y., DESPINS, P., and PERRIGAUD, C.
Abstract: Oxidative stress (OS) had been evaluated in NSCLC using photoproduced singlet oxygen (1O2) deactivating by oxydizing its targets directly or through secondary reactive oxygen species (SOS) production. Either experimentally (orthotopic grafts in mice) or clinically OS changed non linearly with progression. At time of cachexia OS dramatically increased when at a resectable stage in was lower than in controls. In both cases it correlated with a worse prognosis. Vit C or Vit C+GSH have nearly no effect in resectable NSCLC patients but a negative one in controls. Vit E or Vit E + Vit C have a stronger protective effect in NSCLC, dose dependent but not related to the pathology. There was a trend to an inverse relationship OS/Vit D. An eventual adjuvant supplementation during cancers should by controlled on a per-patient basis., Journal of International Society of Antioxidants in Nutrition & Health, Vol 3, No 3 (2016)
Published: 2016
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31. Intraoperative transfusion practices in Europe

Author: Meier, J., Filipescu, D., Kozek Langenecker, S., Llau Pitarch, J., Mallett, S., Martus, P., Matot, I., ETPOS collaborators: Accurso, G., Ahrens, N., Akan, M., Åkeröy, K., Aksoy, O., Alanoğlu, Z., Alfredo, M., Alkis, N., Almeida, V., Alousi, M., Alves, C., Amaral, J., Ambrosi, X., Ana, I., Anastase, D., Andersson, M., Andreou, A., Anthopoulos, G., Apanaviciute, D., Arbelaez, A., Arcade, A., Arion Balescu, C., Arun, O., Azenha, M., Bacalbasa, N., Baeten, W., Balandin, A., Barquero López, M., Barsan, V., Bascuas, B., Basora, M., Baumann, H., Bayer, A., Bell, A., Belmonte Cuenca, J., Bengisun, Z., Bento, C., Beran, M., Bermudez Lopez, M., Bernardino, A., Berthelsen, K., Bigat, Z., Bilshiene, D., Bilska, M., Bisbe Vives, E., Biscioni, T., Björn, H., Blom, T., Bogdan Prodan, A., Bogdanovic Dvorscak, M., Boisson, M., Bolten, J., Bona, F., Borg, F., Boros, C., Borys, M., Boveroux, P., Boztug Uz, N., Brettner, F., Brisard, L., Britta de, W., Browne, G., Budow, K., Buerkle, H., Buggy, D., Cain, A., Calancea, E., Calarasu, F., Calder, V., Camci, A., Campiglia, L., Campos, B., Camps, A., Carlos, D., Carreira, C., Carrilho, A., Carvalho, P., Cassinello, C., Cattan, A., Cenni, L., Cerny, V., Ceyda Meço, B., Chesov, I., Chishti, A., Chupin, A., Cikova, A., Cindea, I., Cintula, D., Ciobanasu, R., Clements, D., Cobiletchi, S., Coburn, M., Coghlan, L., Collyer, T., Copotoiu, S., Copotoiu, R., Corneci, D., CORTEGIANI, Andrea, Coskunfirat, O., Costea, D., Czuczwar, M., Davies, K., De Baerdemaeker, L., De Hert, S., Debernardi, F., Decagny, S., Deger Coskunfirat, N., Diana, T., Diana, G., Dias, S., Dickinson, M., Dobisova, A., Dragan, A., Droc, G., Duarte, S., Dunk, N., Ekelund, K., Ekmekçi, P., Elena, C., Ellimah, T., Espie, L., Everett, L., Ferguson, A., Fernandes, M., Fernández, J., Ferner, M., Ferreira, D., Ferrie, R., Flassikova, Z., Fleischer, A., Font, A., Galkova, K., Garcia, I., Garner, M., Gasenkampf, A., Gelmanas, A., Gherghina, V., Gilsanz, F., Giokas, G., Goebel, U., Gomes, P., Gonçalves Aguiar, J., Gonzalez Monzon, V., Gottschalk, A., Gouraud, J., Gramigni, E., Grintescu, I., Grynyuk, A., Grytsan, A., Guasch, E., Gustin, D., Hans, G., Harazim, H., Hervig, T., Hidalgo, F., Higham, C., Hirschauer, N., Hoeft, A., Innerhofer, P., Innerhofer Pompernigg, N., Jacobs, S., Jakobs, N., Jamaer, L., James, S., Jawad, M., Jesus, J., Jhanji, S., Jipa Lavina, N., Jokinen, J., Jovanovic, G., Jubera, M., Kahn, D., Karjagin, J., Kasnik, D., Katsanoulas, K., Kelle, H., Kelleher, M., Kessler, F., Kirigin, B., Kiskira, O., Kivik, P., Klimi, P., Klučka, J., Koers, L., Kontrimaviciut, E., Koopman van Gemert, A., Korfiotis, D., Kosinová, M., Koursoumi, E., Kranke, P., Kresic, M., Krobot, R., Kropman, L., Kulikov, A., Kvolik, S., Kvrgic, I., Kyttari, A., Lagarto, F., Lance, M., Laufenberg, R., Lauwick, S., Lecoq, J., Leech, L., Lidzborski, L., Liliana, H., Linda, F., Lopes, A., Lopez, L., Lopez Alvarez, A., Lorenzi, I., Lorre, G., Lucian, H., Lupis, T., Lupu, M., Macas, A., Macedo, A., Maggi, G., Mallor, T., Manoleli, A., Manolescu, R., Manrique, S., Maquoi, I., Marios Konstantinos, T., Markovic Bozic, J., Markus, W., Marques, M., Martinez, R., Martinez, E., Martínez, E., Martinho, H., Martins, D., Martires, E., Matias, F., Mauff, S., Meale, P., Merz, H., Meybohm, P., Militello, M., Mincu, N., Miranda, M., Mirea, L., Moghildea, V., Moise, A., Molano Diaz, P., Moltó, L., Monedero, P., Moral, V., Moreira, Z., Moret, E., Mulders, F., Munteanu, A., Nadia Diana, K., Nair, A., Neskovic, V., Ninane, V., Nitu, D., Oberhofer, D., Odeberg Wernerman, S., Oganjan, J., Omur, D., Orallo Moran, M., Ozkardesler, S., Pacasová, R., Paklar, N., Pandazi, A., Papaspyros, F., Paraskeuopoulos, T., Parente, S., Paunescu, M., Pavičić Šarić, J., Pereira, F., Pereira, E., Pereira, L., Perry, C., Petri, A., Petrovic, U., Pica, S., Pinheiro, F., Pinto, J., Pinto, F., Piwowarczyk, P., Platteau, S., Poeira, R., Popescu, R., Popica, G., Poredos, P., Prasser, C., Preckel, B., Prospiech, A., Pujol, R., Raimundo, A., RAINERI, Santi Maurizio, Rakic, D., Ramadan, M., Ramazanoğlu, A., Rantis, A., Raquel, F., Rätsep, I., Real, C., Reikvam, T., Reis, L., Rigal, J., Rohner, A., Rokk, A., Roman Fernandez, A., Rosenberger, P., Rossaint, R., Rozec, B., Rudolph, T., Saeed, Y., Safonov, S., Saka, E., Samama, C., Sánchez López, Ó., Sanchez Perez, D., Sanchez Sanchez, Y., Sandeep, V., Sandu, M., Sanlı, S., Saraiva, A., Scarlatescu, E., Schiraldi, R., Schittek, G., Schnitter, B., Schuster, M., Seco, C., Selvi, O., Senard, M., Serra, S., Serrano, H., Shmigelsky, A., Silva, L., Simeson, K., Singh, R., Sipylaite, J., Skitek, K., Skok, I., Smékalová, O., Smirnova, N., Sofia, M., Soler Pedrola, M., Söndergaard, S., Sõrmus, A., Sørvoll, I., Soumelidis, C., Spindler Yesel, A., Stefan, M., Stevanovic, A., Stevikova, J., Stivan, S., Štourač, P., Striteska, J., Strys, L., Suljevic, I., Tania, M., Tareco, G., Tena, B., Theodoraki, K., Tifrea, M., Tikuisis, R., Tolós, R., Tomasi, R., Tomescu, D., Tomkute, G., Tormos, P., Trepenaitis, D., Troyan, G., Unic Stojanovic, D., Unterrainer, A., Uranjek, J., Valsamidis, D., van Dasselaar, N., Van Limmen, J., van Noord, P., van Poorten, J., Vanderlaenen, M., Varela Garcia, O., Velasco, A., Veljovic, M., Vera Bella, J., Vercauteren, M., Verdouw, B., Verenkin, V., Veselovsky, T., Vieira, H., Villar, T., Visnja, I., Voje, M., von Dossow Hanfstingl, V., Von Langen, D., Vorotyntsev, S., Vujanovič, V., Vukovic, R., Watt, P., Werner, E., Wernerman, J., Wittmann, M., Wright, M., Wunder, C., Wyffels, P., Yakymenko, Y., Yıldırım, Ç., Yılmaz, H., Zacharowski, K., Záhorec, R., Zarif, M., Zielinska Skitek, E., Zsisku, L., Selçuk Üniversitesi, Meier, J., Filipescu, D., Kozek-Langenecker, S., Llau Pitarch, J., Mallett, S., Martus, P., Matot, I., ETPOS collaborators: Accurso, G., Ahrens, N., Akan, M., Åkeröy, K., Aksoy, O., Alanoğlu, Z., Alfredo, M., Alkis, N., Almeida, V., Alousi, M., Alves, C., Amaral, J., Ambrosi, X., Ana, I., Anastase, D., Andersson, M., Andreou, A., Anthopoulos, G., Apanaviciute, D., Arbelaez, A., Arcade, A., Arion-Balescu, C., Arun, O., Azenha, M., Bacalbasa, N., Baeten, W., Balandin, A., Barquero López, M., Barsan, V., Bascuas, B., Basora, M., Baumann, H., Bayer, A., Bell, A., Belmonte Cuenca, J., Bengisun, Z., Bento, C., Beran, M., Bermudez Lopez, M., Bernardino, A., Berthelsen, K., Bigat, Z., Bilshiene, D., Bilska, M., Bisbe Vives, E., Biscioni, T., Björn, H., Blom, T., Bogdan Prodan, A., Bogdanovic Dvorscak, M., Boisson, M., Bolten, J., Bona, F., Borg, F., Boros, C., Borys, M., Boveroux, P., Boztug Uz, N., Brettner, F., Brisard, L., Britta de, W., Browne, G., Budow, K., Buerkle, H., Buggy, D., Cain, A., Calancea, E., Calarasu, F., Calder, V., Camci, A., Campiglia, L., Campos, B., Camps, A., Carlos, D., Carreira, C., Carrilho, A., Carvalho, P., Cassinello, C., Cattan, A., Cenni, L., Cerny, V., Ceyda Meço, B., Chesov, I., Chishti, A., Chupin, A., Cikova, A., Cindea, I., Cintula, D., Ciobanasu, R., Clements, D., Cobiletchi, S., Coburn, M., Coghlan, L., Collyer, T., Copotoiu, S., Copotoiu, R., Corneci, D., Cortegiani, A., Coskunfirat, O., Costea, D., Czuczwar, M., Davies, K., De Baerdemaeker, L., De Hert, S., Debernardi, F., Decagny, S., Deger Coskunfirat, N., Diana, T., Diana, G., Dias, S., Dickinson, M., Dobisova, A., Dragan, A., Droc, G., Duarte, S., Dunk, N., Ekelund, K., Ekmekçi, P., Elena, C., Ellimah, T., Espie, L., Everett, L., Ferguson, A., Fernandes, M., Fernández, J., Ferner, M., Ferreira, D., Ferrie, R., Flassikova, Z., Fleischer, A., Font, A., Galkova, K., Garcia, I., Garner, M., Gasenkampf, A., Gelmanas, A., Gherghina, V., Gilsanz, F., Giokas, G., Goebel, U., Gomes, P., Gonçalves Aguiar, J., Gonzalez Monzon, V., Gottschalk, A., Gouraud, J., Gramigni, E., Grintescu, I., Grynyuk, A., Grytsan, A., Guasch, E., Gustin, D., Hans, G., Harazim, H., Hervig, T., Hidalgo, F., Higham, C., Hirschauer, N., Hoeft, A., Innerhofer, P., Innerhofer-Pompernigg, N., Jacobs, S., Jakobs, N., Jamaer, L., James, S., Jawad, M., Jesus, J., Jhanji, S., Jipa Lavina, N., Jokinen, J., Jovanovic, G., Jubera, M., Kahn, D., Karjagin, J., Kasnik, D., Katsanoulas, K., Kelle, H., Kelleher, M., Kessler, F., Kirigin, B., Kiskira, O., Kivik, P., Klimi, P., Klučka, J., Koers, L., Kontrimaviciut, E., Koopman-van Gemert, A., Korfiotis, D., Kosinová, M., Koursoumi, E., Kozek Langenecker, S., Kranke, P., Kresic, M., Krobot, R., Kropman, L., Kulikov, A., Kvolik, S., Kvrgic, I., Kyttari, A., Lagarto, F., Lance, M., Laufenberg, R., Lauwick, S., Lecoq, J., Leech, L., Lidzborski, L., Liliana, H., Linda, F., Lopes, A., Lopez, L., Lopez Alvarez, A., Lorenzi, I., Lorre, G., Lucian, H., Lupis, T., Lupu, M., Macas, A., Macedo, A., Maggi, G., Mallor, T., Manoleli, A., Manolescu, R., Manrique, S., Maquoi, I., Marios-Konstantinos, T., Markovic Bozic, J., Markus, W., Marques, M., Martinez, R., Martinez, E., Martínez, E., Martinho, H., Martins, D., Martires, E., Matias, F., Mauff, S., Meale, P., Merz, H., Meybohm, P., Militello, M., Mincu, N., Miranda, M., Mirea, L., Moghildea, V., Moise, A., Molano Diaz, P., Moltó, L., Monedero, P., Moral, V., Moreira, Z., Moret, E., Mulders, F., Munteanu, A., Nadia Diana, K., Nair, A., Neskovic, V., Ninane, V., Nitu, D., Oberhofer, D., Odeberg-Wernerman, S., Oganjan, J., Omur, D., Orallo Moran, M., Ozkardesler, S., Pacasová, R., Paklar, N., Pandazi, A., Papaspyros, F., Paraskeuopoulos, T., Parente, S., Paunescu, M., Pavičić Šarić, J., Pereira, F., Pereira, E., Pereira, L., Perry, C., Petri, A., Petrovic, U., Pica, S., Pinheiro, F., Pinto, J., Pinto, F., Piwowarczyk, P., Platteau, S., Poeira, R., Popescu, R., Popica, G., Poredos, P., Prasser, C., Preckel, B., Prospiech, A., Pujol, R., Raimundo, A., Raineri, S., Rakic, D., Ramadan, M., Ramazanoğlu, A., Rantis, A., Raquel, F., Rätsep, I., Real, C., Reikvam, T., Reis, L., Rigal, J., Rohner, A., Rokk, A., Roman Fernandez, A., Rosenberger, P., Rossaint, R., Rozec, B., Rudolph, T., Saeed, Y., Safonov, S., Saka, E., Samama, C., Sánchez López, Ó., Sanchez Perez, D., Sanchez Sanchez, Y., Sandeep, V., Sandu, M., Sanlı, S., Saraiva, A., Scarlatescu, E., Schiraldi, R., Schittek, G., Schnitter, B., Schuster, M., Seco, C., Selvi, O., Senard, M., Serra, S., Serrano, H., Shmigelsky, A., Silva, L., Simeson, K., Singh, R., Sipylaite, J., Skitek, K., Skok, I., Smékalová, O., Smirnova, N., Sofia, M., Soler Pedrola, M., Söndergaard, S., Sõrmus, A., Sørvoll, I., Soumelidis, C., Spindler Yesel, A., Stefan, M., Stevanovic, A., Stevikova, J., Stivan, S., Štourač, P., Striteska, J., Strys, L., Suljevic, I., Tania, M., Tareco, G., Tena, B., Theodoraki, K., Tifrea, M., Tikuisis, R., Tolós, R., Tomasi, R., Tomescu, D., Tomkute, G., Tormos, P., Trepenaitis, D., Troyan, G., Unic-Stojanovic, D., Unterrainer, A., Uranjek, J., Valsamidis, D., van Dasselaar, N., Van Limmen, J., van Noord, P., van Poorten, J., Vanderlaenen, M., Varela Garcia, O., Velasco, A., Veljovic, M., Vera Bella, J., Vercauteren, M., Verdouw, B., Verenkin, V., Veselovsky, T., Vieira, H., Villar, T., Visnja, I., Voje, M., von Dossow-Hanfstingl, V., Von Langen, D., Vorotyntsev, S., Vujanovič, V., Vukovic, R., Watt, P., Werner, E., Wernerman, J., Wittmann, M., Wright, M., Wunder, C., Wyffels, P., Yakymenko, Y., Yıldırım, Ç., Yılmaz, H., Zacharowski, K., Záhorec, R., Zarif, M., Zielinska-Skitek, E., Zsisku, L., Anesthesiology, Graduate School, ACS - Amsterdam Cardiovascular Sciences, and AII - Amsterdam institute for Infection and Immunity
Subjects: AUSTRIAN BENCHMARK, Male, Blood transfusion, medicine.medical_treatment, 610 Medizin, anaemia, anesthesia, blood transfusion, surgery, transfusion trigger, 030204 cardiovascular system & hematology, GUIDELINES, surgery, Cohort Studies, 0302 clinical medicine, 030202 anesthesiology, Medicine and Health Sciences, Medicine, Prospective Studies, Prospective cohort study, ddc:610, Research Support, Non-U.S. Gov't, Middle Aged, Hospitals, Europe, Female, Allogeneic transfusion, Cohort study, medicine.medical_specialty, Transfusion rate, Observational Study, anesthesia, blood transfusion, ELECTIVE SURGERY, Clinical Practice, 03 medical and health sciences, Journal Article, anaemia, transfusion trigger, Humans, Blood Transfusion, Elective surgery, CHLC ANS, Intensive care medicine, Intraoperative Care, business.industry, PREOPERATIVE ANEMIA, PATIENT BLOOD MANAGEMENT, Clinical trial, Anesthesiology and Pain Medicine, Emergency medicine, business, Packed red blood cells, REQUIREMENTS
Abstract: PubMed: 26787795, Background: Transfusion of allogeneic blood influences outcome after surgery. Despite widespread availability of transfusion guidelines, transfusion practices might vary among physicians, departments, hospitals and countries. Our aim was to determine the amount of packed red blood cells (pRBC) and blood products transfused intraoperatively, and to describe factors determining transfusion throughout Europe. Methods: We did a prospective observational cohort study enrolling 5803 patients in 126 European centres that received at least one pRBC unit intraoperatively, during a continuous three month period in 2013. Results: The overall intraoperative transfusion rate was 1.8%; 59% of transfusions were at least partially initiated as a result of a physiological transfusion trigger- mostly because of hypotension (55.4%) and/or tachycardia (30.7%). Haemoglobin (Hb)- based transfusion trigger alone initiated only 8.5% of transfusions. The Hb concentration [mean (sd)] just before transfusion was 8.1 (1.7) g dl-1 and increased to 9.8 (1.8) g dl-1 after transfusion. The mean number of intraoperatively transfused pRBC units was 2.5 (2.7) units (median 2). Conclusions: Although European Society of Anaesthesiology transfusion guidelines are moderately implemented in Europe with respect to Hb threshold for transfusion (7-9 g dl-1), there is still an urgent need for further educational efforts that focus on the number of pRBC units to be transfused at this threshold. © 2016 The Author. Published by Oxford University Press on behalf of the British Journal of Anaesthesia.
Published: 2016

32. Phytoestrogen: Protective effect in HFpEF through ageing?

Author: Dhot, J., Prat, V., Stevant, D., Ferron, M., Persello, A., Aillerie, V., Erraud, A., Erfanian, M., De Waard, M., Rozec, B., Trochu, J.N., Gauthier, C., and Lauzier, B.
Published: 2019
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33. Effect of cardiopulmonary bypass on a stress response pathway in a recovery rat's model

Author: Persello, A., Erraud, A., Aillerie, V., Miniou, P., Guedat, P., De Waard, M., Gauthier, C., Abgueguen, E., Rozec, B., and Lauzier, B.
Published: 2019
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34. O-GlcNAc stimulation, a new hope for children in sepsis?

Author: Denis, M., Dupas, T., Persello, A., Erraud, A., Bigot, E., Lebreton, J., Tessier, A., Issad, T., Gauthier, C., Rozec, B., and Lauzier, B.
Published: 2019
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35. Modulation of carbonic anhydrase activity with O-GlcNacylation stimulation: A new approach to prevent post-cardiopulmonary bypass multi-organ dysfunction.

Author: Lecomte, J., Persello, A., Dupas, T., Pele, T., Rozec, B., Manon, D., and Lauzier, B.
Abstract: O-GlcNAcylation is a post-translational modification involved in stress response. Its stimulation is beneficial in states of shock in murine models with a potential impact on carbonic anhydrase (CA). Cardiopulmonary bypass (CPB) share common pathophysiological mechanism and the cardiovascular alteration associated with remain untreated. Evaluate the impact of (i) O-GlcNAc levels in human and (ii) the impact of O-GlcNAc stimulation during extracorporeal circulation (ECC) and the impact on CA function in rat. A biocollection of human blood samples in adults (n = 36) and children (n = 23) during CPB central venous placement, aortic declamping, 5–6 and 12 hours after declamping. After being anesthetized 24 rats were randomly assigned to receive no therapy, 1-hour ECC or ECC + NButGT to increase O-GlcNAc levels and evaluated 5 hours after ECC weaning. Proteins O-GlcNAcylation and CA levels were evaluated by Western-blot. CA activity was assessed 1 h after treatment on 18 rats receiving NButGT or not. In adults and children undergoing cardiac surgery, CPB was associated with an increase in blood O-GlcNAc levels 6 hours (+29% and +27% respectively P < 0.05) after declamping. ECC model induced multi-organ dysfunction. Treatment with NButGT restored physiological performances: mean arterial pressure at H + 5 (ECC: 70 ± 8 mmHg; ECC + NButGT: 94 ± 7 mmHg; P < 0.05), lactate level at H + 5 (ECC: 3.9 ± 0.9 mmol/L; ECC + NButGT: 1.7 ± 0.2 mmol/L P = 0.08), creatininemia level at H + 5 (ECC: 1.48 ± 0.15 mg/dL; ECC + NButGT: 0.87 ± 0.05 P < 0.0001), and reduced severity score (ECC: 9 ± 0.7; ECC + NButGT: 2 ± 1; P < 0.001). Rats treated with NButGT had a lower CA quantity (−34% P < 0.001), ratio between CA activity and quantity showed higher activity (+62%; P < 0.001) (Fig. 1). Increase in O-GlcNAc level after CPB seems to be a response to stress. Results obtained with O-GlcNAc stimulation in the rat model suggest that this could be a promising strategy for the management of perioperative complication through modulation of CA activity. [ABSTRACT FROM AUTHOR]
Published: 2023
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36. Identification of metabolic targets and signalling pathways involved in the pathophysiology of heart failure with preserved ejection fraction

Author: Dhot, J., Prat, V., Ferron, M., Erraud, A., Aillerie, V., Erfanian, M., Tesse, A., Rozec, B., Steenman, M., Gauthier, C., and Lauzier, B.
Published: 2018
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37. OP-58 - The use of inhaled Nitric Oxide (iNO) in pediatric and adult cardiac centers: a Franco-Belgian multicenter prospective survey from the POSITIVE study group

Author: Gaudard, Philippe, Barbanti, C., Amour, J., Mauriat, P., Rozec, B., M׳Rini, M., Cambonie, G., Liet, J.M., Girard, C., Damas, P., Lecourt, L., and Pouard, P.
Published: 2016
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38. Investigation of the different adrenoceptor targets of nebivolol enantiomers in rat thoracic aorta.

Author: Quang, T. Tran, Rozec, B., Audigane, L., Gauthier, C., and Tran Quang, T
Subjects: *ADRENERGIC receptors, *DRUG receptors, *SYMPATHETIC nervous system, *ENANTIOMERS, *OPTICAL isomers
Abstract: Background and purpose: Nebivolol is a highly selective β1-adrenoceptor antagonist with β3-adrenoceptor agonist properties and is a racemate mixture of D- and L-enantiomers. However, the cellular mechanisms of the effects of each enantiomer are not yet clear and are a matter for debate. The aim of the present experiments was to determine the adrenoceptors involved in the vascular effects of D- and L-enantiomers of nebivolol in rat thoracic aorta. Experimental approach: Responses to nebivolol enantiomers were evaluated in rings of thoracic aorta from male Sprague-Dawley rats. Key results: D-nebivolol (0.1–10 µmol·L−1), but not L-nebivolol, significantly shifted to the right the concentration-response curve to phenylephrine, an α1-adrenoceptor agonist, in a concentration-dependent manner. For the following experiments, aortic rings were constricted with endothelin 1 and now both enantiomers produced an endothelium-dependent relaxation of the rings involving the nitric oxide pathway. This relaxation was not modified by 1 µmol·L−1 CGP 20,712A (β1-adrenoceptor antagonist), but significantly blunted by 7 µmol·L−1 L-74,8337 (β3-adrenoceptor antagonist). However, only the vasorelaxation induced by D-nebivolol was significantly reduced by 1 µmol·L−1 ICI 118,551 (β2-adrenoceptor antagonist). Conclusions and implications: Our results suggest that the nebivolol enantiomers act on different targets. D-nebivolol induced vasorelaxation by activating β2- and β3-adrenoceptors and antagonizing α1-adrenoceptors. L-nebivolol induced vasorelaxation by activating only β3-adrenoceptors in our model. Our results emphasize that nebivolol is a β1-adrenoceptor antagonist with several important pharmacological differences from other β1-adrenoceptor antagonists. Mandarin translation of abstract [ABSTRACT FROM AUTHOR]
Published: 2009
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39. Sepsis is associated with an upregulation of functional β3 adrenoceptors in the myocardium

Author: Moniotte, S., Belge, C., Sekkali, B., Massion, P.B., Rozec, B., Dessy, C., and Balligand, J.-L.
Subjects: ADRENERGIC receptors, SEPSIS, LABORATORY mice, MUSCLE cells, CYTOKINES, CATECHOLAMINES
Abstract: Abstract: Objective: To analyze the implication of the β3-adrenoceptor (β3-AR) pathway in human septic myocardium and a murine model of sepsis, a condition associated with myocardial depression. Methods and results: β3-AR and eNOS protein abundance were increased (332±66.4% and 218±39.3; P <0.05) in hearts from septic patients. The effect of BRL37344, a β3-AR-preferential agonist, was analyzed by videomicroscopy on the contractility of neonatal mouse ventricular myocytes (NMVM) incubated with conditioned medium from LPS-stimulated cultured macrophages (Mc-LPS+ medium). Stimulation of untreated NMVM with BRL37344 dose-dependently decreased the amplitude of contractile shortening (P <0.05). This response was abolished by l-NAME (NOS inhibitor). Incubation in Mc-LPS+ medium potentiated the depressing effect of BRL37344 (P <0.05) as well as of SR58611A (P <0.05) in wild-type myocytes. Importantly, the contractile depression was abrogated in cardiomyocytes from β3-AR KO mice. Conclusions: β3-AR are upregulated during sepsis in the human myocardium and by cytokines in murine cardiomyocytes, where they mediate an increased negative inotropic response to β3 agonists. Activation of the β3-AR pathway by catecholamines may contribute to the myocardial dysfunction in sepsis. [Copyright &y& Elsevier]
Published: 2007
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40. Characterization of beta3-adrenoceptors in human internal mammary artery and putative involvement in coronary artery bypass management.

Author: Rozec B, Serpillon S, Toumaniantz G, Sèze C, Rautureau Y, Baron O, Noireaud J, and Gauthier C
Published: 2005
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41. O-GlcNAc stimulation is beneficial in septic shock models.

Author: Ferron, M., Persello, A., Dhot, J., Aillerie, V., Erraud, A., Riviere, M., Tessier, A., Lebreton, J., Chatham, J.C., De Waard, M., Gauthier, C., Rozec, B., and Lauzier, B.
Abstract: Introduction Septic shock is a worldwide burden, without efficient treatments, killing one person every 3 s. Recently, O-GlcNAc stimulation (a post-translational modification) appeared to be beneficial in acute pathologies. Objective This study has been designed to evaluate if O-GlcNAc stimulation shows the same benefits in two relevant models of septic shock. Method Impact of NButGT (an OGlcNAcase inhibitor – 10 mg/kg) has been evaluated in LPS or CLP (caecal ligation and puncture) and their respective controls with or without fluidotherapy (FR). Cardiovascular function (mean arterial blood pressure (MAP), echocardiography) and biochemical markers (creatinine, lactates) were measured at 3 h and 24 h after shock induction respectively, then heart and blood were harvested to evaluate impact of the treatment. Also, O-GlcNAc impact on calcium actor was evaluated by western blot. LPS study was completed with a Kaplan–Meier mortality evaluation. Results NButGT treatments efficiently increased cardiac O-GlcNAc in both model (+300% vs. Ctrl or Sham). In both group, NButGT treatment induced an amelioration of the outcome and organs function specifically: cardiac (heart rate −9% vs. LPS; −10% vs. CLP), renal (creatinine −35% vs. LPS; −27% vs. CLP) and beneficial impact on blood pressure (MAP + 10% vs. CLP). Treatment had a significant impact on lactate in LPS group (−36% vs. LPS) consistent with a 3 times higher survival rate. Treatment impacted on SERCA2a protein (−150% vs. LPS, NS vs. ctrl) without modification of its regulator (phospholamban) or ryanodine receptor. Conclusion Our results support the fact that acute O-GlcNAc stimulation is a potential new therapeutic target at the early phase of septic shock. Potentially through improvement of cardiomyocytes’ calcium handling. We are currently validating our approach at different dose and age to be able to transfer our results to the clinic. [ABSTRACT FROM AUTHOR]
Published: 2018
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42. Endothelium alteration is a key process in the development of heart failure with preserved ejection fraction.

Author: Burban, M., Dhot, J., Bon-Barret, V., Erraud, A., Tesse, A., Rozec, B., De Waard, M., Gauthier, C., and Lauzier, B.
Abstract: Introduction Endothelial has been suggested to play an important role in the development of heart failure with preserved ejection fraction (HFpEF), but there is no real link so far. Mechanism could involve alteration in vascular structure and reactivity. •NO bioavailability has been suggested to play a central role in this phenomenon and •NO production is partly mediated through β3-adrenoreceptor (β3-AR) activation. Our team developed a transgenic rat (Tgβ3) overexpressing the human β3-AR in the endothelium leading with ageing to HFpEF. Objective The aim of our study was to understand the implication of the endothelium in HFpEF development. Methods Aorta from 45 weeks old rat have been used to evaluate arterial reactivity (aorta and mesenteric rings). Endothelium-dependent relaxation to isoproterenol (0.1 nM to 100 μM) was measured in the presence or absence of •NO synthase (NOS) inhibitors: L-VNIO (NOS-1), 1400 W (NOS-2) and L-NIO (NOS-3) at 10 μM. •NO production in aorta has been evaluated by electron paramagnetic resonance (EPR). Results Concentration-dependent vasodilation to isoproterenol was significantly reduced in Tgβ3 aorta and mesenteric arteries (−10%, P < 0.05 vs. WT) indicating an alteration of endothelial function. With NOS-2 inhibitor, concentration-dependent vasodilation to isoproterenol was unchanged, but vasodilation in presence of NOS-1 and NOS-3 inhibitors was significantly reduced in Tgβ3. Interestingly, vascular production of •NO was increase in Tgβ3 rats (+91%, P < 0.05 vs. WT) while, the main NOS responsible to •NO production, NOS-3, was significantly decreased (−19%, P < 0.05 vs. WT). Conclusion Our animal model demonstrates for the first time that alteration of the endothelial function could lead to HFpEF development. This observation could lead a better understanding of HFpEF pathophysiology, yet evolution of vascular function and •NO production need to be evaluated at different time of HFpEF development. [ABSTRACT FROM AUTHOR]
Published: 2018
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43. Identification of a hypotensive and bradycardic peptide from Black Mamba snake venom.

Author: Bon-Baret, V., Burban, M., Ciolek, J., Servent, D., Ferron, M., Stura, E., Jacquillard, L., Beroud, R., Rozec, B., Gauthier, C., Lauzier, B., Gilles, N., and De Waard, M.
Abstract: Introduction It is estimated that there are about 170,000 venomous species throughout the world. The venom produced by their glands contains hundreds of bioactive compounds. These natural libraries open complete new therapeutic avenues. Heart failure is a cardiac disease associated with morbidities. Recent progress in medicine allowed to develop treatments, yet they are often not highly efficient and possess harmful side effects. Given that venom compounds are pharmacologically active, they can be considered as a source of life-saving therapeutics. Objective The aim of our study is to find therapeutic effects of venom compounds to treat hypertension which can lead to heart failure. Method Black Mamba snake venom fractionations were performed by using cation exchange and RP-HPLC techniques. The obtained fractions and purified compounds were investigated for their ability to displace 3 H-NMS from muscarinic type 2 receptors (M2R). One particular snake peptide, found to be active, was de novo sequenced and synthesized. This peptide was studied in vivo by invasive hemodynamics to evaluate the main cardiovascular parameters ( n = 5, 100 μg/kg) and ex vivo on isolated mesenteric and aorta arteries ( n = 6; 0.8 nM, 8 nM, 80 nM and 8 μM). Wistar rats that were 10–12 weeks old were used for this study. Results After consecutive fractionations of the venom, we succeeded to identify a unique peptide with major hypotension effects. Once injected intravenously in vivo, invasive hemodynamic studies highlighted a significant arterial blood pressure decrease (−65%, P < 0.001) and a reduction in heart rate (−14%, P < 0.001). It also induced a relaxation of mesenteric and aorta arteries (−90%, P < 0.05 vs. baseline). Whether these effects are due to M2R, their regulation will be discussed. Conclusion In this study, we demonstrated the hypotensive effect of an isolated peptide from Black Mamba snake. These results confirm that venom compounds represent a promising opportunity to develop new drugs. [ABSTRACT FROM AUTHOR]
Published: 2018
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44. Identification of potential target involved in the development of heart failure with preserved ejection fraction.

Author: Dhot, J., Prat, V., Persello, A., Aillerie, V., Burban, M., Rozec, B., De Waard, M., Gauthier, C., and Lauzier, B.
Abstract: Introduction Heart failure (HF) with preserved ejection fraction (pEF) is mainly associated with diastolic function. It affects mostly elderly patients with cardiac and non-cardiac comorbidities and is considered as a public health burden. So far, no treatment is available to reduce mortality and morbidity due to lack of knowledge of HFpEF pathophysiology. Our team developed an HFpEF transgenic rat (Tgβ3) overexpressing the human β3-adrenoreceptor in endothelium. Objective The aim of our study is to identify new targets involved in the development of the pathology. Methods Cardiac function was characterized by echocardiography and invasive hemodynamic studies at 45 and 60 weeks of age in male rats ( n = 21/11). Transcriptome analysis was performed on left ventricle (LV) tissue at 45 weeks old rats. Among altered genes we focused on metabolic targets by RT-qPCR and Western-blot. Results At 45 and 60 weeks, Tgβ3 rats presented a significant increase in LV end diastolic pressure (+109% and +175% vs. WT P < 0.01, respectively) and an altered filling pattern with a significant increase in the E/A ratio in Tgβ3 (+15% and +44% vs. WT P < 0.05, respectively). Transcriptome analysis revealed 241 altered genes with 10 genes involved in cardiac metabolism. One potential target of interest (metabolic target 1) was investigated and mRNA and protein levels were increased in Tgβ3 rats at 45 weeks (+62% and +67% P < 0.05 vs. WT, respectively) as well as at 60 weeks of age. These alterations were associated with an increase in the phospho-AMPK to AMPK ratio at 45 and 60 weeks of age (+104% and +71.9% vs. WT, respectively) suggesting a cardiac metabolic remodelling. Conclusion Our results demonstrate a close link between HFpEF development and cardiac remodelling. Understanding the implication of the metabolic target 1 in the development of HFpEF in our model could lead to the identification of new biomarkers or treatment for the patient. [ABSTRACT FROM AUTHOR]
Published: 2018
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45. 148 - Identification of signalling pathways potentially involved in the development of heart failure with preserved ejection fraction.

Author: Dhot, J., Steenman, M., Prat, V., Ferron, M., Persello, A., Erraud, A., Rozec, B., Lauzier, B., and Gauthier, C.
Published: 2017
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46. Evaluation of NT-proBNP in coronary artery bypass surgery: OFF-pump versus ON-pump.

Author: Rozec, B., Frémiot, K., Delaroche, O., Bizouarn, P., Despins, P., and Blanloeil, Y.
Published: 2005

47. Chlorhexidine-alcohol compared with povidone-iodine-alcohol skin antisepsis protocols in major cardiac surgery: a randomized clinical trial.

Author: Boisson M, Allain G, Roussel JC, d'Ostrevy N, Burbassi S, Demondion P, Mertes PM, Labaste F, Kerforne T, Rozec B, Eljezi V, Zannis K, Leprince P, Oulehri W, Minville V, Seguin S, Loiodice A, Ruckly S, Lucet JC, Timsit JF, and Mimoz O
Abstract: Purpose: Whether skin disinfection of the surgical site using chlorhexidine-alcohol is superior to povidone-iodine-alcohol in reducing reoperation and surgical site infection rates after major cardiac surgery remains unclear., Methods: CLEAN 2 was a multicenter, open-label, randomized, two-arm, assessor-blind, superiority trial conducted in eight French hospitals. We randomly assigned adult patients undergoing major heart or aortic surgery via sternotomy, with or without saphenous vein or radial artery harvesting, to have all surgical sites disinfected with either 2% chlorhexidine-alcohol or 5% povidone-iodine-alcohol. The primary outcome was any resternotomy by day 90 or any reoperation at the peripheral surgical site by day 30., Results: Of 3242 patients (1621 in the chlorhexidine-alcohol group [median age, 69 years; 1276 (78.7%) men] and 1621 in the povidone-iodine-alcohol group [median age, 69 years; 1247 (76.9%) men], the percentage required reoperation within 90 days was similar (7.7% [125/1621] in the chlorhexidine-alcohol group vs 7.5% [121/1621] in the povidone-iodine-alcohol group; risk difference, 0.25 [95% confidence interval (CI), - 1.58-2.07], P = 0.79). The incidence of surgical site infections at the sternum or peripheral sites was similar (4% [65/1621] in the chlorhexidine-alcohol group vs 3.3% [53/1621] in the povidone-iodine-alcohol group; risk difference, 0.74 [95% CI - 0.55-2.03], P = 0.26). Length of hospital stay, intensive care unit or hospital readmission, mortality and surgical site adverse events were similar between the two groups., Conclusion: Among patients requiring sternotomy for major heart or aortic surgery, skin disinfection at the surgical site using chlorhexidine-alcohol was not superior to povidone-iodine-alcohol for reducing reoperation and surgical site infection rates., Competing Interests: Declarations Conflicts of interest MB reports grants from Becton Dickinson; consulting fees from Becton Dickinson and Edwards LifesSciences; honoraria for lectures from Becton Dickinson; and payment for participation on an advisory board for Becton Dickinson and Edwards LifesSciences. BR reports grants from Aguettant and i-SEP; consulting fees from LFB, Aguettant and Nordic Pharma; and attending meetings or travel from i-SEP. JFT reports grants from MSD and Pfizer; honoraria for lectures from Becton Dickinson and Shionogi; and payment for participation on an advisory board for MSD, Pfizer, Gilead, Advanz, Roche and Becton Dickinson. OM reports grants from 3 M and Becton Dickinson; consulting fees from 3 M and Becton Dickinson; honoraria for lectures from 3 M and Becton Dickinson; support for attending meetings or travel from 3 M and Becton Dickinson; and payment for participation on an advisory board for 3 M and Becton Dickinson. All other authors declare no competing interests. Role of the funder The funders had no role in the design or execution of the trial, data analysis, or writing or reviewing of the manuscript. Data sharing Data collected for the study, including participant data, the data dictionary defining each field in the set, and the study protocol, will be made available to others. Data will be communicated as de-identified participant data according to French law, and will be available after publication of the manuscript. Data will be made available at the Direction de la Recherche, Poitiers University Hospital, Poitiers, France (drci@chu-poitiers.fr), with investigator support, after approval of a proposal with a signed data access agreement., (© 2024. The Author(s).)
Published: 2024
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48. Workload assessment using the nursing activities score in intensive care units: Nationwide prospective observational study in France.

Author: Dauvergne JE, Bruyneel A, Caillet A, Caillet P, Keriven-Dessomme B, Tack J, Rozec B, and Poiroux L
Abstract: Background: Within French intensive care units (ICUs), patients are treated with two levels of care (intensive or intermediate) with different nurse-to-patient ratios legally defined., Objectives: We aimed to compare the nursing workload associated with these two levels of care., Research Methodology: A nationwide prospective observational study was conducted in France between April and July 2023. Each ICU was allowed to choose its own two-week period of data collection during which the Nursing Activities Score was collected by nurses at patients' bedside, during each shift. The Nursing Activities Score ranges from 20 to 177% and a 100% score represents a nurse per shift. The number of patients per nurse was collected and the Nursing Activities Score per nurse was assessed., Results: One hundred and five ICUs participated. Overall, 21,665 measurements of Nursing Activities Score per patient and 9,885 Nursing Activities Score per nurse were collected. ICUs were composed by 2083 beds distributed into 1520 (73 %) intensive care beds and 563 (27 %) intermediate care beds. Among the participating units, 93 (89 %) of the teams worked in 2 shifts. Median [p25-p75] Nursing Activities Score per adult patient was 61 % [49-80] for intensive care patients and 47 % [38-61] for intermediate care patients (p < 0.001). Median Nursing Activities Score per nurse for adult population was 127 % [92-167], 143 % [92-198], and 164 % [126-213] for nurses only providing intensive care, only intermediate care or both levels of care, respectively (p < 0.001). A Nursing Activities Score per nurse value >100 % was observed in 71.4 %., Conclusions: Nurses' workload was high in the ICU, especially when providing intermediate or mixed levels of care., Implications for Practice: In order to reduce nurses' workload, a review of the nurse-to-patient ratios is expected. Physically separating the two levels of care may be a valuable option., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Published: 2024
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49. Hemolysis Index, Carboxyhemoglobin, and Methemoglobin for the Early Identification of Patients at Risk for Cardiac Surgery-Associated Acute Kidney Injury.

Author: Golinvaux E, Goronflot T, Cadiet J, Senage T, Rozec B, Boissier E, Bigot-Corbel E, and Lakhal K
Abstract: Objectives: Hemolysis is a contributor to CS-AKI. Biochemistry analyzers provide a hemolysis index to quantify in vitro hemolysis, a condition that can, for example, affect the accuracy of potassium concentration measurements. We aimed to assess whether the postoperative plasma level of the hemolysis index (HI postoperative ) could aid the early recognition of patients at risk for cardiac surgery-associated acute kidney injury (CS-AKI) and also to evaluate other hemolysis indicators: plasma carboxyhemoglobin (COHb postoperative ) and methemoglobin (MetHb postoperative )., Design: One-year retrospective study., Setting: University hospital., Participants: Patients undergoing elective cardiac surgery., Interventions: None., Measurements and Main Results: In 1090 patients, the median HI postoperative was higher in patients who developed CS-AKI compared to patients who did not (11 mg/dL [interquartile range (IQR), 5-38 mg/dL] v 7 mg/dL [IQR, 3-16 mg/dL]; p < 0.001). HI postoperative refined the early recognition of CS-AKI: the area under the precision-recall curve (AUPRC) for HI postoperative was 37% (95% confidence interval [CI], 31%-42%), whereas the AUPRC associated with no discriminative power, equal to the prevalence of CS-AKI in the whole population, was 21%. Among the 611 patients with measurements for all 3 biomarkers, the AUPRC of HI postoperative was higher than that of COHb postoperative or MetHb postoperative (+6.6% and +7.4% respectively; p < 0.0001 for both). Unlike COHb postoperative or MetHb postoperative , the incorporation of HI postoperative into a model (trained on a sample then validated in another sample) of CS-AKI early recognition significantly enhanced its performance, with a +1.9% (95% CI, 1.6%-2.1%) increase in AUPRC (p < 0.0001)., Conclusions: Elevated HI postoperative represents an early alert signal for the development of CS-AKI. Our findings support the incorporation of HI postoperative , a readily available biomarker, into predictive scores of CS-AKI., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Published: 2024
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50. Noninvasive Arterial Pressure Measurements at the Lower Leg: Evaluation of the Influence of Patient Position (Semi-Recumbent or Horizontal)-A prospective study.

Author: Lakhal K, Audran A, Normand G, Rozec B, Dauvergne JE, and Boulain T
Abstract: Competing Interests: Financial/Nonfinancial Disclosures The authors have reported to CHEST the following: K. L. is a consultant on the Advisory Board of Philips. In addition, K. L. received, during the past 3 years, congress registration from Pfizer (once in 2022) and both congress registration and travel fees from Advanz Pharma/Correvio (once in 2021) and from AOP Health (once in 2024). B. R. received, during the past 5 years, lecture fees from Fisher&Paykel, Baxter, LFB, and Aspen, research grants from Baxter and Aguettant, and consulting fees from LFB, Aguettant, and Astra Zeneca. None declared (A. A., G. N., J. E. D., T. B.)
Published: 2024
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