3 results on '"Rosliza Abdul Rahman"'
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2. The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey
- Author
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Siti Amrah Sulaiman, Rosliza Abdul Rahman, Ahmad Sukari Halim, Siew Hua Gan, Kirnpal-Kaur Bs, Siti Asma' Hassan, and Hern Tze Tan
- Subjects
Acinetobacter baumannii ,animal structures ,Serial dilution ,Stenotrophomonas maltophilia ,Microbial Sensitivity Tests ,Biology ,Manuka Honey ,Microbiology ,Agar plate ,Minimum inhibitory concentration ,Food science ,Minimum bactericidal concentration ,Bacteria ,fungi ,digestive, oral, and skin physiology ,food and beverages ,lcsh:Other systems of medicine ,Honey ,General Medicine ,lcsh:RZ201-999 ,Antimicrobial ,biology.organism_classification ,Anti-Bacterial Agents ,Gastroenteritis ,Complementary and alternative medicine ,Wound Infection ,behavior and behavior mechanisms ,Antibacterial activity ,Research Article - Abstract
Background Antibiotic resistance of bacteria is on the rise, thus the discovery of alternative therapeutic agents is urgently needed. Honey possesses therapeutic potential, including wound healing properties and antimicrobial activity. Although the antimicrobial activity of honey has been effectively established against an extensive spectrum of microorganisms, it differs depending on the type of honey. To date, no extensive studies of the antibacterial properties of tualang (Koompassia excelsa) honey on wound and enteric microorganisms have been conducted. The objectives of this study were to conduct such studies and to compare the antibacterial activity of tualang honey with that of manuka honey. Methods Using a broth dilution method, the antibacterial activity of tualang honey against 13 wound and enteric microorganisms was determined; manuka honey was used as the control. Different concentrations of honey [6.25-25% (w/v)] were tested against each type of microorganism. Briefly, two-fold dilutions of honey solutions were tested to determine the minimum inhibitory concentration (MIC) against each type of microorganism, followed by more assays within a narrower dilution range to obtain more precise MIC values. MICs were determined by both visual inspection and spectrophotometric assay at 620 nm. Minimum bactericidal concentration (MBC) also was determined by culturing on blood agar plates. Results By visual inspection, the MICs of tualang honey ranged from 8.75% to 25% compared to manuka honey (8.75-20%). Spectrophotometric readings of at least 95% inhibition yielded MIC values ranging between 10% and 25% for both types of honey. The lowest MBC for tualang honey was 20%, whereas that for manuka honey was 11.25% for the microorganisms tested. The lowest MIC value (8.75%) for both types of honey was against Stenotrophomonas maltophilia. Tualang honey had a lower MIC (11.25%) against Acinetobacter baumannii compared to manuka honey (12.5%). Conclusion Tualang honey exhibited variable activities against different microorganisms, but they were within the same range as those for manuka honey. This result suggests that tualang honey could potentially be used as an alternative therapeutic agent against certain microorganisms, particularly A. baumannii and S. maltophilia.
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3. Contaminated parenteral nutrition solution causing a series of neonatal nosocomial infections by Serratia marcescens.
- Author
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Zaidah Abdul Rahman, Habsah Hasan, Zeehaida Mohamed, Siti Suraiya Md. Noor, Rosliza Abdul Rahman, Maimunah Hassan, and Siti Asma Hassan
- Subjects
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PARENTERAL feeding , *SERRATIA marcescens , *SERRATIA , *SEPTICEMIA in children , *NEONATAL diseases - Abstract
Serratia marcescens previously was thought to be a low pathogenic bacterium but has recently being recognized as a nosocomial pathogen. In May 2007, patients with nosocomial septicemia caused by S. marcescens were identified in a neonatal intensive care unit (NICU) at a tertiary-teaching hospital. The objective of this report is to highlight the rare source of the S. marcescens outbreak. Here, we describe the investigations and outcomes of this outbreak. Case subject was defined as any neonate receiving medical care at the NICU, from one week before the index patient became symptomatic and onwards, with clinical signs and symptoms of sepsis, with or without a positive blood culture, which yielded S. marcescens. Chart reviews were conducted for case subjects. Various samples from the NICU were sent for sterility testing including medications, solutions, used and freshly prepared total parenteral nutrition (TPN) from the NICU and the pharmacy unit. The specimens were processed and positive isolates were identified as S. marcescens using standard microbiological methods. it S. marcescens isolates were subjected to pulsed field gel electrophoresis for molecular typing and source identification. S. marcescens were isolated from five neonates, used TPN and freshly prepared TPN of different batches in pharmacy. None of the environmental samples and medications grew S. marcescens. Analysis of macrorestriction patterns of genomic DNA by pulsed field gel electrophoresis demonstrated indistinguishable patterns. This outbreak was related to bacterial contamination of TPN. This report points at a rare source of S. marcescens outbreak. However, targeted investigations and immediate active interventions enabled the managing team to control the outbreak in the NICU. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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