993 results on '"Rose‐John, Stefan"'
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2. Effect of intravitreal injection of anti-interleukin (IL)-6 antibody in experimental autoimmune uveitis in mice
3. A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling
4. Targeting IL-6 trans-signalling: past, present and future prospects
5. Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2 -infected mice and reduces endotheliopathy
6. An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
7. STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway
8. The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130
9. Blockade of the protease ADAM17 ameliorates experimental pancreatitis
10. Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema
11. EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells
12. The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation
13. Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling
14. The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo
15. More and more pleiotropy within the IL‐6 family of cytokines.
16. Idiopathic multicentric Castleman disease with marrow fibrosis and extramedullary hematopoiesis.
17. IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells
18. Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease
19. ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer
20. Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis
21. Blocking only the bad side of IL-6 in inflammation and cancer
22. Therapeutic targeting of IL-6 trans-signaling
23. Interleukin-6: obstacles to targeting a complex cytokine in critical illness
24. Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease
25. New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology
26. Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate
27. Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice
28. Interleukin-6 controls recycling and degradation, but not internalization of its receptors
29. The two facets of gp130 signalling in liver tumorigenesis
30. Increased Expression of the Neuropeptides PACAP/VIP in the Brain of Mice with CNS Targeted Production of IL-6 Is Mediated in Part by Trans-Signalling.
31. Single‐cell transcriptomics reveals a senescence‐associated IL‐6/CCR6 axis driving radiodermatitis
32. Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN
33. IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants
34. Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner
35. Interleukin-6 plays a critical role in aldosterone-induced macrophage recruitment and infiltration in the myocardium
36. Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice
37. Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
38. IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling
39. IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer’s disease
40. Interleukin 6 Dependent Synaptic Plasticity in a Social Defeat-Susceptible Prefrontal Cortex Circuit
41. ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury
42. Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3
43. Pharmacologic IL-6Rα inhibition in cholangiocarcinoma promotes cancer cell growth and survival
44. Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice
45. Degradome of soluble ADAM10 and ADAM17 metalloproteases
46. Treatment of type 2 diabetes with the designer cytokine IC7Fc
47. Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing
48. Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB
49. The shedding protease ADAM17: Physiology and pathophysiology
50. Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice
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