16 results on '"Ronza, Fm"'
Search Results
2. Combined magnetic resonance spectroscopy and dynamic contrast-enhanced imaging for prostate cancer detection
- Author
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Francesco Michele Ronza, Roberta Fusco, Riccardo Autorino, Michele Caraglia, Sisto Perdonà, Carlo Buonerba, Matteo Ferro, Marco De Sio, Giuseppe Di Lorenzo, Sergio Venanzio Setola, Antonella Petrillo, Perdonà, S, Di Lorenzo, G, Autorino, Riccardo, Buonerba, C, DE SIO, Marco, Setola, Sv, Fusco, R, Ronza, Fm, Caraglia, Michele, Ferro, M, and Petrillo, A.
- Subjects
Male ,medicine.medical_specialty ,Prostate biopsy ,Magnetic Resonance Spectroscopy ,Urology ,Biopsy ,Population ,Contrast Media ,Multimodal Imaging ,Sensitivity and Specificity ,Cohort Studies ,Prostate cancer ,chemistry.chemical_compound ,Imaging, Three-Dimensional ,Meglumine ,Predictive Value of Tests ,medicine ,Organometallic Compounds ,Humans ,Prospective Studies ,education ,Aged ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Magnetic resonance spectroscopic imaging ,Prostatic Neoplasms ,Reproducibility of Results ,Magnetic resonance imaging ,Middle Aged ,Prostate-Specific Antigen ,medicine.disease ,Magnetic Resonance Imaging ,Contrast medium ,Oncology ,chemistry ,Gadoteric acid ,Radiology ,Neoplasm Grading ,business - Abstract
Background The use of magnetic resonance spectroscopy imaging (MRSI) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) have emerged as a valid diagnostic tools for prostate cancer (CaP). Methods Men with PSA levels below 10 ng/ml were enrolled in a prospective cohort study and underwent combined MRSI and DCE-MRI and transrectal ultrasound-guided prostate biopsy. Imaging was performed using a 1.5 T MR scanner (Symphony TIM; Siemens, Erlangen, Germany) with an endorectal coil (Medrad; Pittsburg, PA), inflated with 60 cc of air. Three-dimensional magnetic resonance spectroscopic data were acquired by using water and a lipid-suppressed double-spin-echo point-resolved spectroscopy sequence, which was optimized for quantitative detection of both choline and citrate. Dynamic contrast-enhanced MRI sequences were obtained with 3D T1-weighted FLASH images before and during rapid bolus administration of intravenous paramagnetic contrast medium gadoteric acid. Specificity, sensitivity, positive predictive value, negative predictive value, and accuracy were computed considering patients, each of the 2 lobes, each of the 6 sextants, and each 12th part of the prostate gland as single measurements. Results Overall, 106 patients were included in the analysis. Median age was 65.9 years (range, 61.2–70.5 years) and median PSA level at study entry was 7.1 ng/ml (range, 2.5–9.9). CaP was detected at biopsy in 24 patients (22.6 % of the population) with a median Gleason score of 8 (range 4–10). Diagnostic accuracy of combined MRSI and DCE-MRI was 85%, sensitivity was 71%, and specificity was 48%, considering patients as single measurements, with a negative predictive value of 91%, but a positive predictive value of only 19%. Positive predictive value of the examination improved to 25% for patients who repeated biopsy. Conclusions Although this study confirms the potential usefulness of MRI for the diagnosis of CaP, the positive predictive value obtained was unacceptably low due to the high number of false positives recorded. Nevertheless, the high negative predictive value of the examination may serve to avoid unnecessary biopsies. Future research should be directed at assessing the value of combining MRI-based techniques with novel biochemical markers for the diagnosis of CaP in patients with low PSA levels.
- Published
- 2013
3. CT-guided radiofrequency ablation in the treatment of recurrent rectal cancer
- Author
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Francesco Michele Ronza, G. Belfiore, Maria Paola Belfiore, Enrico Tedeschi, Antonio Rotondo, Giovanni Pietro Ianniello, Ettore Borsi, Belfiore, G, Tedeschi, Enrico, Ronza, Fm, Belfiore, Mp, Borsi, E, Ianniello, Gp, Rotondo, A., Tedeschi, E, and Rotondo, Antonio
- Subjects
Male ,medicine.medical_specialty ,Radiofrequency ablation ,medicine.medical_treatment ,extravascular interventional radiology, palliative treatment, radiofrequency ablation, rectal cancer recurrence, thermoablation ,Adenocarcinoma ,law.invention ,law ,medicine ,Rectal Adenocarcinoma ,Humans ,Radiology, Nuclear Medicine and imaging ,Brief Pain Inventory ,Aged ,Rectal Neoplasms ,Abdominoperineal resection ,business.industry ,Cancer ,General Medicine ,Middle Aged ,Ablation ,medicine.disease ,Surgery ,Radiation therapy ,Treatment Outcome ,Surgery, Computer-Assisted ,Catheter Ablation ,Female ,Radiology ,Neoplasm Recurrence, Local ,Tomography, X-Ray Computed ,business ,Ablation zone - Abstract
Locally recurrent rectal adenocarcinoma remains a therapeutic challenge that is unsatisfactorily managed by surgery and radiation therapy or chemotherapy. Palliative CT-guided radiofrequency ablation was used in 14 patients with recurrent rectal adenocarcinoma who had been previously treated with abdominoperineal resection and radiation therapy. Follow-up CT or MRI was performed at 3, 6, 12, and 24 months. Pain palliation was monitored by the brief pain inventory (BPI). One month after radiofrequency ablation, 11 patients reported satisfactory BPI mean scores reduction compared to baseline (from 7.6 to 3.4 and from 5.1 to 1.6 for worst and average pain, respectively). In two unresponsive patients, retreatment was successfully performed at 3 months. After 24 months, worst and average pain scores further decreased (to 2.6 and 0.8, respectively) in 10 patients, who, at imaging, showed an ablation zone covering the entire original lesion in two patients and incomplete ablation in eight. In our experience, radiofrequency ablation is a safe and effective palliative treatment for patients with recurrent rectal adenocarcinoma.
- Published
- 2009
4. The hidden bridging of left anterior descending artery.
- Author
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Ronza FM, Di Gennaro TL, Gragnano F, Golia E, Iodice M, Posillico G, Rucco MA, Pariggiano I, Sullo P, and Calabrò P
- Subjects
- Humans, Male, Computed Tomography Angiography, Coronary Vessels diagnostic imaging, Middle Aged, Coronary Angiography methods, Coronary Vessel Anomalies diagnostic imaging, Coronary Vessel Anomalies complications
- Published
- 2024
- Full Text
- View/download PDF
5. CTA Imaging of Peripheral Arterial Injuries.
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Tamburrini S, Lassandro G, Tiralongo F, Iacobellis F, Ronza FM, Liguori C, Comune R, Pezzullo F, Galluzzo M, Masala S, Granata V, Basile A, and Scaglione M
- Abstract
Traumatic vascular injuries consist of direct or indirect damage to arteries and/or veins and account for 3% of all traumatic injuries. Typical consequences are hemorrhage and ischemia. Vascular injuries of the extremities can occur isolated or in association with major trauma and other organ injuries. They account for 1-2% of patients admitted to emergency departments and for approximately 50% of all arterial injuries. Lower extremities are more frequently injured than upper ones in the adult population. The outcome of vascular injuries is strictly correlated to the environment and the time background. Treatment can be challenging, notably in polytrauma because of the dilemma of which injury should be prioritized, and treatment delay can cause disability or even death, especially for limb vascular injury. Our purposes are to discuss the role of computed tomography angiography (CTA) in the diagnosis of vascular trauma and its optimized protocol to achieve a definitive diagnosis and to assess the radiological signs of vascular injuries and the possible pitfalls.
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- 2024
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6. Diagnostic Role of Multi-Detector Computed Tomography in Acute Mesenteric Ischemia.
- Author
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Ronza FM, Di Gennaro TL, Buzzo G, Piccolo L, Della Noce M, Giordano G, Posillico G, Pietrobono L, Mazzei FG, Ricci P, Masala S, Scaglione M, and Tamburrini S
- Abstract
Mesenteric ischemia diagnosis is challenging, with an overall mortality of up to 50% of cases despite advances in treatment. The main problem that affects the outcome is delayed diagnosis because of non-specific clinical presentation. Multi-Detector CT Angiography (MDCTA) is the first-line investigation for the suspected diagnosis of vascular abdominal pathologies and the diagnostic test of choice in suspected mesenteric bowel ischemia. MDCTA can accurately detect the presence of arterial and venous thrombosis, determine the extent and the gastrointestinal tract involved, and provide detailed information determining the subtype and the stage progression of the diseases, helping clinicians and surgeons with appropriate management. CT (Computed Tomography) can differentiate forms that are still susceptible to pharmacological or interventional treatment (NOM = non-operative management) from advanced disease with transmural necrosis in which a surgical approach is required. Knowledge of CT imaging patterns and corresponding vascular pathways is mandatory in emergency settings to reach a prompt and accurate diagnosis. The aims of this paper are 1. to provide technical information about the optimal CTA (CT Angiography) protocol; 2. to explain the CTA arterial and venous supply to the gastrointestinal tract and the relevant ischemic pattern; and 3. to describe vascular, bowel, and extraintestinal CT findings for the diagnosis of acute mesenteric ischemia.
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- 2024
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- View/download PDF
7. Recurrence of tumoral calcinosis: a case report.
- Author
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Sandomenico F, Corvino A, Ronza FM, Catalano O, Fazioli F, De Chiara A, Campanino MR, Porcaro M, Tafuri D, and Petrillo A
- Subjects
- Humans, Male, Middle Aged, Recurrence, Calcinosis diagnostic imaging, Hyperostosis, Cortical, Congenital diagnostic imaging, Hyperphosphatemia diagnostic imaging, Magnetic Resonance Imaging, Multidetector Computed Tomography
- Abstract
We describe radiographic, contrast-enhanced MDCT and MRI findings with pathologic correlations of an unusual recurrence of tumoral calcinosis, also called Teutschlander disease. The disease was silent in the first decade of life, when it appeared with elbows recurring lesions, until the seventh decade of life, when a left hip active growth lesion developed. A review about tumoral calcinosis pathogenesis, clinical course and imaging differential diagnosis is reported. (www.actabiomedica.it).
- Published
- 2019
- Full Text
- View/download PDF
8. Percutaneous CT-guided irreversible electroporation followed by chemotherapy as a novel neoadjuvant protocol in locally advanced pancreatic cancer: Our preliminary experience.
- Author
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Belfiore MP, Ronza FM, Romano F, Ianniello GP, De Lucia G, Gallo C, Marsicano C, Di Gennaro TL, and Belfiore G
- Subjects
- Adenocarcinoma diagnostic imaging, Adenocarcinoma pathology, Aged, Aged, 80 and over, Antineoplastic Agents administration & dosage, Combined Modality Therapy, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Electroporation, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Recurrence, Local diagnostic imaging, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Organoplatinum Compounds administration & dosage, Oxaliplatin, Pancreatic Neoplasms diagnostic imaging, Pancreatic Neoplasms pathology, Prospective Studies, Tomography, X-Ray Computed, Treatment Outcome, Gemcitabine, Adenocarcinoma therapy, Neoplasm Recurrence, Local therapy, Pancreatic Neoplasms therapy
- Abstract
Introduction: Irreversible electroporation (IRE) is a non-thermal ablation technique recently used in pancreatic cancer. In our prospective study we evaluated safety, feasibility and efficacy of a neoadjuvant protocol based on CT-guided percutaneous IRE followed by chemotherapy in patients with locally advanced pancreatic cancer (LAPC)., Methods: We performed CT-guided percutaneous IRE in 20 patients with LAPC, followed by a combination of gemcitabine (1000 mg/mq) and oxaliplatin (100 mg/mq) biweekly. Imaging follow-up was performed by a contrast enhanced CT scan at 1, 3, 6 months and then every 3 months., Results: No major complications occurred. Two patients died 3 and 4 months after IRE because of rapidly progressive disease. In the remaining 18 patients 6-month imaging follow-up showed a mean lesions volumetric decrease percentage of 42.89% (95% Confidence Interval: 34.90-54.88%). Thanks to lesions downstaging, three patients underwent R0 resection. At last available follow-up (mean follow-up 91 months; range 6-14), imaging showed no disease progression or post-surgical relapse in all 18 cases. The mean estimated survival was 12,950 months (95% CI: 11,570-14,332)., Conclusions: Our preliminary study suggests that IRE followed by chemotherapy is safe, feasible and effective in producing local control of LAPC, with a possible downstaging effect to resectable lesions., (Copyright © 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
9. Long-term local disease control in a recurrent soft-tissue sarcoma of the thigh treated by radiofrequency ablation.
- Author
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Belfiore MP, Ronza FM, Della Volpe T, Pascale M, and Belfiore G
- Subjects
- Aged, 80 and over, Female, Humans, Neoplasm Recurrence, Local, Thigh surgery, Ablation Techniques, Histiocytoma, Malignant Fibrous surgery, Radiofrequency Therapy, Soft Tissue Neoplasms surgery
- Abstract
In 2008, we performed radiofrequency ablation (RFA) in an elderly patient with a large recurrent soft-tissue sarcoma of the thigh, previously treated with surgery and radiotherapy. After ablation, a marked shrinkage of tumor was obtained. Further local recurrences occurred during follow-up, all safely treated by RFA, with local control of the disease maintained until 6-year follow-up. RFA was safe, effective, and repeatable for soft-tissue sarcoma recurrences, and allowed long-term local control of the disease., (© 2015 Wiley Periodicals, Inc.)
- Published
- 2015
- Full Text
- View/download PDF
10. Multiparametric MRI for prostate cancer detection: performance in patients with prostate-specific antigen values between 2.5 and 10 ng/mL.
- Author
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Petrillo A, Fusco R, Setola SV, Ronza FM, Granata V, Petrillo M, Carone G, Sansone M, Franco R, Fulciniti F, and Perdonà S
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- Aged, Humans, Image Interpretation, Computer-Assisted methods, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Biomarkers, Tumor blood, Diffusion Magnetic Resonance Imaging methods, Kallikreins blood, Magnetic Resonance Spectroscopy methods, Multimodal Imaging methods, Prostate-Specific Antigen blood, Prostatic Neoplasms blood, Prostatic Neoplasms diagnosis
- Abstract
Purpose: To assess the diagnostic performance of multiparametric MRI (mpMRI), in the detection of prostate cancer, including morphologic sequences (mMRI), diffusion-weighted imaging (DWI), and MR spectroscopy (MRS). Combined morphological and functional MRI scoring systems was used for urological–radiological work-up of patients with a prostate-specific antigen (PSA) value ≤ 10 ng/mL., Materials and Methods: The study included 136 of 200 consecutive patients with PSA values between 2.5 and 4 ng/mL and an abnormal digital rectal examination (DRE), or patients with PSA values between 4 and 10 ng/mL, independently from DRE. Each patient provided informed consent to undergo at serum free/total PSA ratio (f/t PSA) assay, mMRI, MRS, DWI, and transrectal ultrasonography (TRUS) biopsy. The MRI datasets were scored singularly; then mMRI and DWI, mMRI and MRS data were combined in a coupled score, and finally mMRI, DWI, and MRS data were combined in a single score (cMRI score)., Results: Scores were correlated to negative biopsies and significant/insignificant Gleason score biopsies. Receiver-operator-characteristic curve and McNemar tests were performed. Cancer was diagnosed in 18% of patients. The cMRI score showed: (i) the highest sensitivity (0.84) and negative predictive value (0.93); (ii) a significant correlation with Gleason score; and (iii) a statistically different median value between significant and insignificant Gleason score., Conclusion: The cMRI score could identify patients with a PSA≤10 ng/mL who will have a negative work-up, for its high negative predictive value, and patients at high risk for significant prostate cancer because of its correlation with the Gleason score
- Published
- 2014
- Full Text
- View/download PDF
11. Combined magnetic resonance spectroscopy and dynamic contrast-enhanced imaging for prostate cancer detection.
- Author
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Perdonà S, Di Lorenzo G, Autorino R, Buonerba C, De Sio M, Setola SV, Fusco R, Ronza FM, Caraglia M, Ferro M, and Petrillo A
- Subjects
- Aged, Biopsy, Cohort Studies, Humans, Imaging, Three-Dimensional, Male, Meglumine pharmacology, Middle Aged, Multimodal Imaging, Neoplasm Grading, Organometallic Compounds pharmacology, Predictive Value of Tests, Prospective Studies, Prostate-Specific Antigen blood, Reproducibility of Results, Sensitivity and Specificity, Contrast Media pharmacology, Magnetic Resonance Imaging methods, Magnetic Resonance Spectroscopy methods, Prostatic Neoplasms diagnosis, Prostatic Neoplasms pathology
- Abstract
Background: The use of magnetic resonance spectroscopy imaging (MRSI) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) have emerged as a valid diagnostic tools for prostate cancer (CaP)., Methods: Men with PSA levels below 10 ng/ml were enrolled in a prospective cohort study and underwent combined MRSI and DCE-MRI and transrectal ultrasound-guided prostate biopsy. Imaging was performed using a 1.5 T MR scanner (Symphony TIM; Siemens, Erlangen, Germany) with an endorectal coil (Medrad; Pittsburg, PA), inflated with 60 cc of air. Three-dimensional magnetic resonance spectroscopic data were acquired by using water and a lipid-suppressed double-spin-echo point-resolved spectroscopy sequence, which was optimized for quantitative detection of both choline and citrate. Dynamic contrast-enhanced MRI sequences were obtained with 3D T1-weighted FLASH images before and during rapid bolus administration of intravenous paramagnetic contrast medium gadoteric acid. Specificity, sensitivity, positive predictive value, negative predictive value, and accuracy were computed considering patients, each of the 2 lobes, each of the 6 sextants, and each 12th part of the prostate gland as single measurements., Results: Overall, 106 patients were included in the analysis. Median age was 65.9 years (range, 61.2-70.5 years) and median PSA level at study entry was 7.1 ng/ml (range, 2.5-9.9). CaP was detected at biopsy in 24 patients (22.6 % of the population) with a median Gleason score of 8 (range 4-10). Diagnostic accuracy of combined MRSI and DCE-MRI was 85%, sensitivity was 71%, and specificity was 48%, considering patients as single measurements, with a negative predictive value of 91%, but a positive predictive value of only 19%. Positive predictive value of the examination improved to 25% for patients who repeated biopsy., Conclusions: Although this study confirms the potential usefulness of MRI for the diagnosis of CaP, the positive predictive value obtained was unacceptably low due to the high number of false positives recorded. Nevertheless, the high negative predictive value of the examination may serve to avoid unnecessary biopsies. Future research should be directed at assessing the value of combining MRI-based techniques with novel biochemical markers for the diagnosis of CaP in patients with low PSA levels., (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
12. Fatty bronchogram: a sign of cystic teratoma rupture in the lung.
- Author
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Rossi G, Ronza FM, Porto A, and De Rosa N
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- Adipose Tissue diagnostic imaging, Adipose Tissue pathology, Biopsy, Needle, Follow-Up Studies, Humans, Immunohistochemistry, Male, Mediastinal Neoplasms diagnosis, Mediastinal Neoplasms surgery, Middle Aged, Multidetector Computed Tomography methods, Neoplasm Staging, Rupture, Spontaneous diagnostic imaging, Rupture, Spontaneous surgery, Sepsis diagnosis, Sepsis etiology, Teratoma diagnosis, Teratoma surgery, Thoracotomy methods, Treatment Outcome, Bronchography methods, Mediastinal Neoplasms diagnostic imaging, Teratoma diagnostic imaging
- Abstract
A 47-year-old man was admitted to our hospital for septic fever. Multidetector computed tomography showed a pulmonary cavitated consolidation that was partially filled by low-density material and an interrupted rim of soft tissue in adjacent mediastinum, lining an inhomogeneous fat density area. Lung consolidation presented a bronchogram fluid sign with a -40 Hounsfield unit density value, which indicated a fatty bronchogram. Mediastinal cystic teratoma rupture in the lung was derived from a bacterial infection, with the lipoid material pouring into the lung and its drainage bronchus.
- Published
- 2011
13. Intermittent pericardial bleeding from cardiac trauma: computed tomography findings.
- Author
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Valente T, Caianiello G, Ronza FM, Pelella G, Muto R, and Rotondo A
- Subjects
- Cardiac Surgical Procedures, Child, Female, Heart Atria diagnostic imaging, Heart Atria injuries, Heart Injuries complications, Heart Injuries surgery, Hemorrhage etiology, Hemorrhage surgery, Humans, Multiple Trauma complications, Pericardial Effusion etiology, Pericardial Effusion surgery, Predictive Value of Tests, Suture Techniques, Treatment Outcome, Accidents, Traffic, Heart Injuries diagnostic imaging, Hemorrhage diagnostic imaging, Multiple Trauma diagnostic imaging, Pericardial Effusion diagnostic imaging, Tomography, X-Ray Computed
- Published
- 2011
- Full Text
- View/download PDF
14. Hippocampal asymmetry with hippocampal sulcus remnants in a patient with mild cognitive impairment. A case report.
- Author
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Conforti R, Ronza FM, Di Costanzo A, De Cristofaro M, Cirillo M, and Cirillo S
- Abstract
A 65-year-old woman underwent MRI for a mild cognitive impairment (MCI) at Mini-Mental State Examination (MMSE). MRI showed hippocampal sulcus remnants bilaterally, although they were larger on the right, and left hippocampal atrophy with increased left fimbriosubicular distance (right side: 1.2 mm; left side: 2.0 mm). The meaning of these findings in relation to clinical aspects is discussed and reviewed according to data from the literature.
- Published
- 2010
- Full Text
- View/download PDF
15. CT-guided radiofrequency ablation in the treatment of recurrent rectal cancer.
- Author
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Belfiore G, Tedeschi E, Ronza FM, Belfiore MP, Borsi E, Ianniello GP, and Rotondo A
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Treatment Outcome, Adenocarcinoma diagnostic imaging, Adenocarcinoma surgery, Catheter Ablation methods, Neoplasm Recurrence, Local diagnostic imaging, Neoplasm Recurrence, Local surgery, Rectal Neoplasms diagnostic imaging, Rectal Neoplasms surgery, Surgery, Computer-Assisted methods, Tomography, X-Ray Computed methods
- Abstract
Objective: Locally recurrent rectal adenocarcinoma remains a therapeutic challenge that is unsatisfactorily managed by surgery and radiation therapy or chemotherapy. Palliative CT-guided radiofrequency ablation was used in 14 patients with recurrent rectal adenocarcinoma who had been previously treated with abdominoperineal resection and radiation therapy. Follow-up CT or MRI was performed at 3, 6, 12, and 24 months. Pain palliation was monitored by the brief pain inventory (BPI)., Conclusion: One month after radiofrequency ablation, 11 patients reported satisfactory BPI mean scores reduction compared to baseline (from 7.6 to 3.4 and from 5.1 to 1.6 for worst and average pain, respectively). In two unresponsive patients, retreatment was successfully performed at 3 months. After 24 months, worst and average pain scores further decreased (to 2.6 and 0.8, respectively) in 10 patients, who, at imaging, showed an ablation zone covering the entire original lesion in two patients and incomplete ablation in eight. In our experience, radiofrequency ablation is a safe and effective palliative treatment for patients with recurrent rectal adenocarcinoma.
- Published
- 2009
- Full Text
- View/download PDF
16. Radiofrequency ablation of bone metastases induces long-lasting palliation in patients with untreatable cancer.
- Author
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Belfiore G, Tedeschi E, Ronza FM, Belfiore MP, Della Volpe T, Zeppetella G, and Rotondo A
- Subjects
- Aged, Female, Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Neoplasm Metastasis, Osteolysis therapy, Pain Management, Radio Waves, Tomography, X-Ray Computed methods, Treatment Outcome, Bone Neoplasms therapy, Catheter Ablation, Palliative Care methods
- Abstract
Introduction: In oncological patients, life quality can be greatly impaired by the presence of painful bone metastases, as standard forms of treatment often achieve inadequate palliation. The aim of our study was to evaluate the clinical efficacy of radiofrequency ablation (RFA) with respect to pain relief in patients with refractory bone metastases or who are ineligible to conventional treatments., Methods: 12 patients with 13 painful osteolytic skeletal metastases, and who were unresponsive to analgesic drug therapy, underwent one (seven lesions) or two (five lesions) RFA sessions under computed tomography (CT) guidance. The RFA procedure was completed in all patients without complications. One patient also received cementoplasty after the RFA procedure. To obtain semiquantitative pain scores, the brief pain inventory (BPI) was administered before treatment and during follow-up. The local effects of RFA were monitored for at least one year in eight of 12 patients with CT and/or magnetic resonance imaging., Results: Immediate pain relief after treatment was experienced by nine of 12 patients, but in two cases, pain recurred within the first week. Long-lasting palliation was obtained in seven of 12 patients. BPI mean scores for worst and average daily pain decreased from 7.7 and 5.0, respectively, at baseline, to 3.1 and 1.8, respectively, at one year. Imaging follow-up showed large areas of necrosis in nine of 12 lesions., Conclusion: In our preliminary experience, RFA showed good and long-lasting efficacy for pain control in bone metastases. A possible role of RFA as a coadjuvant palliative treatment in these cases is suggested.
- Published
- 2008
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