79 results on '"Rongchong Huang"'
Search Results
2. M2 macrophage-derived exosomes promote angiogenesis and improve cardiac function after myocardial infarction
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Hongzhou Guo, Zeya Li, Bin Xiao, and Rongchong Huang
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M2 macrophages ,Exosomes ,Angiogenesis ,Myocardial infarction ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background Myocardial infarction (MI) is a major cause of mortality and morbidity worldwide. The intercellular communication in post-infarction angiogenesis remains unclear. Methods In this study, we explored the role and mechanism of action of M2 macrophage-derived exosomes (M2-exos) in angiogenesis after MI. M2-exos were harvested and injected intramyocardially at the onset of MI. Two distinct endothelial cells (ECs) were cultured with M2-exos to explore the direct effects on angiogenesis. Results We showed that M2-exos improved cardiac function, reduced infarct size, and enhanced angiogenesis after MI. Moreover, M2-exos promoted angiogenesis in vitro; the molecules loaded in the vesicles were responsible for its proangiogenic effects. We further validated that higher abundance of miR-132-3p in M2-exos, which recapitulate their functions, was required for the cardioprotective effects exerted by M2-exos. Mechanistically, miR-132-3p carried by M2-exos down-regulate the expression of THBS1 through direct binding to its 3´UTR and the proangiogenic effects of miR-132-3p were largely reversed by THBS1 overexpression. Conclusion Our findings demonstrate that M2-exos promote angiogenesis after MI by transporting miR-132-3p to ECs, and by binding to THBS1 mRNA directly and negatively regulating its expression. These findings highlight the role of M2-exos in cardiac repair and provide novel mechanistic understanding of intercellular communication in post-infarction angiogenesis.
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- 2024
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3. Association of blood pressure variability with target organ damage in older patients with essential hypertension
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Zhiquan Jing, Gang Wang, Zeya Li, Shanshan Wu, Xiang Qiu, and Rongchong Huang
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ambulatory blood pressure monitoring ,blood pressure variability ,hypertension ,target organ damage ,Medicine (General) ,R5-920 - Abstract
Abstract Background Although multiple measures of blood pressure variability (BPV) have been proposed, whether they are better than mean blood pressure in predicting target organs is unclear. We aimed to determine the relationship between short term BPV and target organ injury. Methods This study was a retrospective study, and 635 inpatients in the Department of Cardiology from 2015 to 2020 were selected. We divided participants into four groups on the basis of the quartiles of BPV. One‐way analysis of variance was used to compare the differences between the groups, and linear regression was used to analyze the relationship between BPV and target organ damage. Results The average age of 635 patients was 74.36 ± 6.50 years old. Among them, 354 of 627 patients had diminished renal function (56.5%), 221of 604 patients had associated left ventricular hypertrophy (36.6%), and 227 of 231 patients had carotid plaque formation (98.3%). The baseline data indicated significant differences in fasting glucose, total cholesterol, low‐density lipoprotein, creatinine, glomerular filtration rate, sex, calcium channel blocker use, and the rate of diminished renal function. Multiple linear regression analysis showed that BPV was negatively correlated with renal injury (creatinine: r = 0.306, p
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- 2023
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4. Global and national burden of atherosclerosis from 1990 to 2019: trend analysis based on the Global Burden of Disease Study 2019
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Weihua Chen, Zeya Li, Yu Zhao, Yitian Chen, Rongchong Huang, and Rongman Jia
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Medicine - Abstract
Abstract. Background:. Atherosclerosis-related diseases represent significant health issues among adults globally. Despite their widespread impact, comprehensive data concerning the global and national burden and trends of these diseases remain sparse. Our objective is to examine the trends in the burden of atherosclerosis among adults from 1990 to 2019 at both global and national levels. Methods:. We reported the average annual percentage changes (AAPCs) in prevalence, incidence, mortality, and disability-adjusted life years (DALYs) of atherosclerosis-related diseases (ischemic heart disease [IHD], ischemic stroke, and peripheral arterial disease [PAD]) at the global and national levels among individuals based on a trend analysis of the Global Burden of Diseases Study (GBD) 2019. We further analyzed these global trends as a function of age, gender, and the social development index. We also used joinpoint regression analysis to identify the year with the most substantial changes in global trends. Results:. Globally, the AAPC of IHD incidence rose from 1990 to 2019 (0.20; 95% confidence interval [CI], 0.12-0.28), with substantial surges in 1995, 2001, 2005, 2010, and 2017. Conversely, AAPC of IHD mortality rates exhibited a different trend until a rise in 2014. The AAPC of incidence rates of ischemic stroke and PAD also escalated during the same period, with respective 0.43 (95% CI, 0.39-0.48) and 0.13 (95% CI, 0.06-0.21). For ischemic stroke, both incidence and mortality soared in 2014, while PAD incidence declined in 1994 and 1998, then sharply climbed in 2016. Nationally, the Northern Mariana Islands experienced the steepest increase in IHD and PAD incidence and mortality between 1990 and 2019. China saw a significant rise in ischemic stroke incidence, whereas the highest mortality rate increase occurred in Timor-Leste. By sociodemographic index (SDI) quintile, low-middle-, middle-, and high-middle-SDI countries all showed upward trends in IHD, ischemic stroke, and PAD incidence. Simultaneously, IHD and ischemic stroke mortality rates, as well as DALYs, dropped in the low-, high-middle-, and high-SDI nations. However, PAD mortality rates and DALYs saw an uptick across all SDI quintiles. Regarding age demographics, a global decrease in the AAPC IHD incidence as noted in individuals above 55 years old, in contrast to an increase in the 20-55 age group during this period. AAPC of mortality rates for IHD, ischemic stroke, and PAD decreased across all ages. The AAPC showed an increase in IHD incidence in both genders. Conversely, IHD's DALYs saw a reduction in both males and females. Ischemic stroke patterns mirrored these trends, whereas all measures for PAD exhibited growth for both sexes. Conclusions:. From 1990 to 2019, there was an overall increasing trend in the global incidence of all three clinical manifestations of atherosclerosis. Between 1990 and 2019, both the mortality rate and DALYs for IHD and ischemic stroke declined across all age groups. Overall, the burden of atherosclerosis-related diseases has not significantly decreased and even shows signs of trending upward. These findings strongly suggest that despite some progress made, efforts to control atherosclerosis diseases globally need to be intensified.
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- 2023
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5. Association between the insulin resistance marker TyG index and subsequent adverse long-term cardiovascular events in young and middle-aged US adults based on obesity status
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Weihua Chen, Shan Ding, Jiabin Tu, Guitao Xiao, Kaihong Chen, Yanbin Zhang, Rongchong Huang, and Ying Liao
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All-cause mortality ,Triglyceride-glucose index ,Obesity ,Cardiovascular events ,NHANES ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background A lthough the triglyceride-glucose (TyG) index has been shown to closely correlate with cardiometabolic outcomes and predict cardiovascular events in many groups, it remains unclear whether obese status in young and middle-aged adults is associated with long-term unfavorable cardiovascular events. This warrants further investigation. Methods This retrospective cohort study analyzed data from the National Health and Nutrition Examination Survey spanning the years 1999–2018, with follow-up for mortality status until December 31, 2019. To categorize participants based on the TyG level, the optimal critical value was determined through restricted cubic spline function analysis, dividing them into high and low TyG groups. The study assessed the relationship between TyG and cardiovascular events and all-cause mortality in young and middle-aged adults stratified by obesity status. Kaplan‒Meier and Cox proportional risk models were used to analyze the data. Results During a follow-up period of 123 months, a high TyG index increased the risk of cardiovascular events by 63% (P = 0.040) and the risk of all-cause mortality by 32% (P = 0.010) in individuals after adjusting for all covariates. High TyG was shown to be linked to cardiovascular events in obese people (Model 3: HR = 2.42, 95% CI = 1.13–5.12, P = 0.020); however, there was no significant difference in TyG groups for nonobese adults in Model 3 (P = 0.08). Conclusions TyG was independently associated with harmful long-term cardiovascular events in young and middle-aged US populations, with a stronger association observed in those who were obese.
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- 2023
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6. Effect of complete percutaneous revascularization on improving long-term outcomes of patients with chronic total occlusion and multi-vessel disease
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Zeya Li, Ziru Zhou, Lei Guo, Lei Zhong, Jingnan Xiao, Shaoke Meng, Yingdong Wang, Huaiyu Ding, Bo Zhang, Hao Zhu, Xuchen Zhou, Rongchong Huang, Rongman Jia, and Xiuyuan Hao
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Medicine - Abstract
Abstract. Background:. Limited data are available on the comparison of clinical outcomes of complete vs. incomplete percutaneous coronary intervention (PCI) for patients with chronic total occlusion (CTO) and multi-vessel disease (MVD). The study aimed to compare their clinical outcomes. Methods:. A total of 558 patients with CTO and MVD were divided into the optimal medical treatment (OMT) group (n = 86), incomplete PCI group (n = 327), and complete PCI group (n = 145). Propensity score matching (PSM) was performed between the complete and incomplete PCI groups as sensitivity analysis. The primary outcome was defined as the occurrence of major adverse cardiovascular events (MACEs), and unstable angina was defined as the secondary outcome. Results:. At a median follow-up of 21 months, there were statistical differences among the OMT, incomplete PCI, and complete PCI groups in the rates of MACEs (43.0% [37/86] vs. 30.6% [100/327] vs. 20.0% [29/145], respectively, P = 0.016) and unstable angina (24.4% [21/86] vs. 19.3% [63/327] vs. 10.3% [15/145], respectively, P = 0.010). Complete PCI was associated with lower MACE compared with OMT (adjusted hazard ratio [HR] = 2.00; 95% confidence interval [CI] = 1.23–3.27; P = 0.005) or incomplete PCI (adjusted HR = 1.58; 95% CI = 1.04–2.39; P = 0.031). Sensitivity analysis of PSM showed similar results to the above on the rates of MACEs between complete PCI and incomplete PCI groups (20.5% [25/122] vs. 32.6% [62/190], respectively; adjusted HR = 0.55; 95% CI = 0.32–0.96; P = 0.035) and unstable angina (10.7% [13/122] vs. 20.5% [39/190], respectively; adjusted HR = 0.48; 95% CI = 0.24–0.99; P = 0.046). Conclusions:. For treatment of CTO and MVD, complete PCI reduced the long-term risk of MACEs and unstable angina, as compared with incomplete PCI and OMT. Complete PCI in both CTO and non-CTO lesions can potentially improve the prognosis of patients with CTO and MVD.
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- 2023
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7. Good coronary collateral circulation is not associated with better prognosis in patients with chronic total occlusion, regardless of treatment strategy
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Zeya Li, Yingdong Wang, Shanshan Wu, Jingnan Xiao, Lei Guo, Shaoke Meng, Lei Zhong, Huaiyu Ding, Haichen Lv, Xuchen Zhou, and Rongchong Huang
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Chronic total occlusion ,coronary collateral circulation ,percutaneous coronary intervention ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective: This study aimed to assess the effects of coronary collateral circulation (CCC) on the prognosis of patients with chronic total occlusion (CTO) under different treatment strategies. Methods: We analyzed a total of 1124 patients who were diagnosed with CTO and divided them into groups with good CCC (grade 2 to 3, n = 539) or poor CCC (grade 0 to 1, n = 531). The primary outcome was cardiac death during follow-up; the secondary outcome was major adverse cardiovascular events (MACEs). We also performed subgroup analyses in groups with and without CTO revascularization (CTO-R and CTO-NR, respectively), and sensitivity analyses excluding patients who received failed CTO-PCI to further investigate the effect of CCC. Results: During a median follow-up duration of 23 months, we did not detect any significant differences between the good CCC group and the poor CCC group in terms of cardiac death (4.2% vs 4.1%; adjusted hazard ratio [HR], 1.01; 95% confidence interval [CI], 0.56–1.83; p = 0.970) and MACEs (23.6% vs 23.2%; adjusted HR, 1.07; 95% CI, 0.84–1.37; p = 0.590). Subgroup analyses according to CTO revascularization showed similar results. In addition, we observed no differences in sensitivity analyses when patients who received failed CTO-PCI were excluded. Conclusion: Good CCC was not associated with a lower risk of cardiac death or MACEs among patients with CTO, regardless of whether the patients received CTO revascularization treatment.
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- 2023
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8. Nutrition-related diseases and cardiovascular mortality in American society: national health and nutrition examination study, 1999–2006
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Weihua Chen, Shanshan Shi, Jiabin Tu, Lihua Liao, Ying Liao, Kaihong Chen, Liling Chen, and Rongchong Huang
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Cardiovascular mortality ,Malnutrition-sarcopenia syndrome ,Nutrition-related diseases ,National Health and Nutrition Examination Survey ,Society ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Despite many significant advances in treatment and management, cardiovascular disease remains the main cause of the global disease burden. Nutrition-related disease is a modifiable cardiovascular risk factor. However, few studies have examined the relationship between nutrition-related diseases and cardiovascular mortality. Objective We aimed to investigate the association of nutrition-related diseases with cardiovascular mortality based on a large nationally representative community population. Design We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 1999–2006 with mortality follow-up through December 31, 2015. Finally, 12,469 participants were analyzed. Each participant was assigned to one of four groups: normal nutrition without sarcopenia, sarcopenia with normal nutrition, malnutrition without sarcopenia, and malnutrition-sarcopenia syndrome. Survival curves and Cox regressions based on the NHANES recommended weights were used to assess the association between nutrition-related diseases and cardiovascular mortality. Results Of the 12,469 patients included in the study and divided into four groups, malnutrition-sarcopenia syndrome had the highest 5- and 10-year cardiovascular mortality rates. After adjustment for related factors, sarcopenia with normal nutrition (hazard ratio [HR]: 1.62, 95% confidence interval [CI]: 1.28–2.06; P
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- 2022
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9. QRS score: A simple marker to quantify the extent of myocardial scarring in patients with chronic total arterial occlusion
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Hongzhou Guo, Xuan Zhou, Jiaying Xu, Zhishuai Ye, Lei Guo, and Rongchong Huang
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chronic total occlusion ,late gadolinium enhancement cardiac magnetic resonance imaging ,myocardial scar ,Selvester QRS score ,Medicine (General) ,R5-920 - Abstract
Abstract Background Chronic total occlusion (CTO) is a critical and unique subgroup of coronary lesions. This study aimed to investigate the correlation between the Selvester QRS score and late gadolinium enhancement cardiac magnetic resonance imaging (LGE‐CMRI) in quantifying myocardial scarring to provide a simple and feasible method for treating CTO. Methods The medical records of 134 patients with absolute CTO who underwent coronary angiography between May 1, 2014 and December 30, 2017 were retrospectively reviewed. All patients were grouped according to the CTO location (right coronary artery [RCA] CTO, left artery descending [LAD] CTO, left circumflex [LCX] CTO, and multivessel CTO groups). The degree of myocardial scarring was determined according to the Selvester QRS score and using the LGE‐CMRI. All patients were followed up for at least 12 months. Results Among the 62 CTO patients, 55 had occlusion of a single vessel and seven had occlusion of multiple vessels, of which 27 (43.55%) were in the RCA CTO group, 16 (25.81%) in the LAD CTO group, 12 (19.35%) in the LCX CTO group, and 7 (11.29%) in the multivessel CTO group. The area under the receiver operating characteristic curve for the QRS score that was used to determine the degree of myocardial scarring was 0.806, with a sensitivity and specificity of 94.7% and 42.1%, respectively. The Selvester QRS score and LGE‐CMRI measures of scar size were correlated in the RCA CTO, LCX CTO, and multivessel CTO groups (r = 0.466, 0.593, and 0.775, respectively). Conclusion The Selvester QRS score was feasible for detecting myocardial scarring in patients with CTO.
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- 2022
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10. Pathophysiology and molecular mechanism of caveolin involved in myocardial protection strategies in ischemic conditioning
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Xin Zhao, Xueyao Yang, Ziyu An, Libo Liu, Jingwen Yong, Haoran Xing, Rongchong Huang, Jinfan Tian, and Xiantao Song
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Myocardial protection ,Caveolins ,Pathophysiology ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Multiple pathophysiological pathways are activated during the process of myocardial injury. Various cardioprotective strategies protect the myocardium from ischemia, infarction, and ischemia/reperfusion (I/R) injury through different targets, yet the clinical translation remains limited. Caveolae and its structure protein, caveolins, have been suggested as a bridge to transmit damage-preventing signals and mediate the protection of ultrastructure in cardiomyocytes under pathological conditions. In this review, we first briefly introduce caveolae and caveolins. Then we review the cardioprotective strategies mediated by caveolins through various pathophysiological pathways. Finally, some possible research directions are proposed to provide future experiments and clinical translation perspectives targeting caveolin based on the investigative evidence.
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- 2022
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11. Association of sarcopenia with ideal cardiovascular health metrics among US adults: a cross-sectional study of NHANES data from 2011 to 2018
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Kaihong Chen, Shanshan Shi, Kun Huang, Ying Liao, Weihua Chen, Yizhou Jiang, and Rongchong Huang
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Medicine - Abstract
Objective The American Heart Association (AHA) proposed the concept of ideal cardiovascular health (CVH) to reduce the risk of cardiovascular mortality. We attempted to broaden the impact of CVH and further contribute to AHA 2030 goals by identifying the relationship between CVH and non-cardiovascular diseases such as sarcopenia.Design Cross-sectional surveySetting National Health and Nutrition Examination Survey conducted in the USA from 2011 to 2018.Participants This study included participants with reliable first 24-hour dietary recall and ≥20 years of age and excluded those who could not diagnose sarcopenia or insufficient data to calculate the CVH scores.Primary and secondary outcome measures The prevalence of sarcopenia as measured by dual-energy X-ray absorptiometry.Results This cohort study involving 9326 adults≥20 years comprised 4733 females (50.0%). The number of intermediate or ideal and poor CVH participants was 5654 and 3672 with mean CVH score of 9.70±0.03 and 5.66±0.04, respectively. After adjusting for related confounding factors, intermediate or ideal CVH was associated with an odds reduction of sarcopenia than poor CVH (adjusted OR (aOR): 0.36, 95% CI 0.26 to 0.50, p5, the odds of sarcopenia decreased by up to 84% (aOR: 0.16, 95% CI 0.08 to 0.30).Conclusions Our findings suggest a relationship between the CVH and the prevalence of sarcopenia in adults. The results of our study can contribute to achieving the 2030 public health goal of achieving CVH for all, which may be supported by efforts to reduce the prevalence of sarcopenia.
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- 2022
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12. Long-term outcomes of medical therapy versus successful recanalisation for coronary chronic total occlusions in patients with and without type 2 diabetes mellitus
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Lei Guo, Junjie Wang, Huaiyu Ding, Shaoke Meng, Xiaoyan Zhang, Haichen Lv, Lei Zhong, Jian Wu, Jiaying Xu, Xuchen Zhou, and Rongchong Huang
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Chronic total occlusions ,Diabetes ,Percutaneous coronary intervention ,Medical therapy ,Outcomes ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background In this study, we compared the outcomes of medical therapy (MT) with successful percutaneous coronary intervention (PCI) in chronic total occlusions (CTO) patients with and without type 2 diabetes mellitus. Methods A total of 2015 patients with CTOs were stratified. Diabetic patients (n = 755, 37.5%) and non-diabetic patients (n = 1260, 62.5%) were subjected to medical therapy or successful CTO-PCI. We performed a propensity score matching (PSM) to balance the baseline characteristics. A comparison of the major adverse cardiac events (MACE) was done to evaluate long-term outcomes. Results The median follow-up duration was 2.6 years. Through multivariate analysis, the incidence of MACE was significantly higher among diabetic patients compared to the non-diabetic patients (adjusted hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.09–1.61, p = 0.005). Among the diabetic group, the rate of MACE (adjusted HR 0.61, 95% CI 0.42–0.87, p = 0.006) was significantly lower in the successful CTO-PCI group than in the MT group. Besides, in the non-diabetic group, the prevalence of MACE (adjusted HR 0.85, 95% CI 0.64–1.15, p = 0.294) and cardiac death (adjusted HR 0.94, 95% CI 0.51–1.70, p = 0.825) were comparable between the two groups. Similar results as with the early detection were obtained in propensity-matched diabetic and non-diabetic patients. Notably, there was a significant interaction between diabetic or non-diabetic with the therapeutic strategy on MACE (p for interaction = 0.036). Conclusions For treatment of CTO, successful CTO-PCI highly reduces the risk of MACE in diabetic patients when compared with medical therapy. However, this does not apply to non-diabetic patients.
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- 2020
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13. Two-year clinical outcomes of medical therapy vs. revascularization for patients with coronary chronic total occlusion
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Lei Guo, Jian Wu, Lei Zhong, Huaiyu Ding, Jiaying Xu, Xuchen Zhou, and Rongchong Huang
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Chronic total occlusions ,Revascularization ,Medical therapy ,Outcome ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objectives: There are little data on the long-term clinical outcomes of medical therapy (MT) compared with revascularization in patients with chronic total occlusions (CTOs). Methods: Between January 2007 and December 2016, a total of 1655 patients with ≥1 CTO were enrolled in our center and were divided into the MT group (n = 800) and revascularization group (n = 855) according to the initial treatment strategy. Propensity score matching was also performed to adjust for baseline characteristics. The primary outcome was cardiac death. Results: After 2 years of follow-up, there was no significant difference between the two groups with regard to the prevalence of cardiac death (MT vs. revascularization: 6.6% vs. 4.2%, adjusted hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.60–1.49, p = 0.820). In the propensity-matched population (406 pairs), there were no significant differences in the prevalence of cardiac death (MT vs. revascularization: 5.4% vs. 4.7%, HR 0.88, 95% CI 0.48–1.63, p = 0.694), except for target vessel revascularization (TVR) (0.44, 0.31–0.63,
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- 2020
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14. Elevated Wnt2 and Wnt4 activate NF-κB signaling to promote cardiac fibrosis by cooperation of Fzd4/2 and LRP6 following myocardial infarction
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Chao Yin, Zhishuai Ye, Jian Wu, Chenxing Huang, Le Pan, Huaiyu Ding, Lei Zhong, Lei Guo, Yan Zou, Xiang Wang, Ying Wang, Pan Gao, Xuejuan Jin, Xiaoxiang Yan, Yunzeng Zou, Rongchong Huang, and Hui Gong
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Wnt ,Cardiac fibrosis ,Myocardial infarction ,Frizzled ,NF-κB ,Medicine ,Medicine (General) ,R5-920 - Abstract
Background: Acute myocardial infarction (AMI)-induced excessive myocardial fibrosis exaggerates cardiac dysfunction. However, serum Wnt2 or Wnt4 level in AMI patients, and the roles in cardiac fibrosis are largely unkown. Methods: AMI and non-AMI patients were enrolled to examine serum Wnt2 and Wnt4 levels by ELISA analysis. The AMI patients were followed-up for one year. MI mouse model was built by ligation of left anterior descending branch (LAD). Findings: Serum Wnt2 or Wnt4 level was increased in patients with AMI, and the elevated Wnt2 and Wnt4 were correlated to adverse outcome of these patients. Knockdown of Wnt2 and Wnt4 significantly attenuated myocardial remodeling and cardiac dysfunction following experimental MI. In vitro, hypoxia enhanced the secretion and expression of Wnt2 and Wnt4 in neonatal rat cardiac myocytes (NRCMs) or fibroblasts (NRCFs). Mechanistically, the elevated Wnt2 or Wnt4 activated β-catenin /NF-κB signaling to promote pro-fibrotic effects in cultured NRCFs. In addition, Wnt2 or Wnt4 upregulated the expression of these Wnt co-receptors, frizzled (Fzd) 2, Fzd4 and (low-density lipoprotein receptor-related protein 6 (LRP6). Further analysis revealed that Wnt2 or Wnt4 activated β-catenin /NF-κB by the co-operation of Fzd4 or Fzd2 and LRP6 signaling, respectively. Interpretation: Elevated Wnt2 and Wnt4 activate β-catenin/NF-κB signaling to promote cardiac fibrosis by cooperation of Fzd4/2 and LRP6 in fibroblasts, which contributes to adverse outcome of patients with AMI, suggesting that systemic inhibition of Wnt2 and Wnt4 may improve cardiac dysfunction after MI.
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- 2021
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15. Focus on HFpEF in heart failure
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Chunhui He, Rongchong Huang, and Ningning Wang
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Medicine - Published
- 2022
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16. Clinical Outcomes of Concomitant Use of Proton Pump Inhibitors and Dual Antiplatelet Therapy: A Systematic Review and Meta-Analysis
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Hongzhou Guo, Zhishuai Ye, and Rongchong Huang
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proton pump inhibitors ,coronary artery disease ,dual antiplatelet therapy ,medication interaction ,adverse cardiovascular events ,meta-analysis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: The safety and efficacy associated with the use of proton pump inhibitors (PPIs) by patients with coronary artery disease receiving dual antiplatelet therapy (DAPT) remain unclear.Methods: The evaluated outcomes included combined major adverse cardiovascular events (MACEs), myocardial infarction (MI), all-cause mortality, and gastrointestinal (GI) bleeding. A random effects meta-analysis, stratified by study design, was performed and heterogeneity was assessed using the I2 statistic.Results: In total, 6 randomized controlled trials (RCTs) (6930 patients) and 16 observational studies (183,546 patients) were included. Analysis of RCTs showed that there were no significant differences in the incidences of MACEs (risk ratio [RR] = 0.89 [95% confidence interval (CI) = 0.75–1.05]), MI (RR = 0.93 [95% CI = 0.76–1.15]), and all-cause mortality (RR = 0.79 [95% CI = 0.50–1.23]) in the PPI groups vs. the non-PPI groups. Pooled data from observational studies revealed an inconsistent association between the use of each PPI subtype and the increased risks of MACEs during clopidogrel treatment. There was no increased risk of MACEs or all-cause mortality associated with the use of PPIs (as a class) and other P2Y12 inhibitors. Both the RCTs and observational studies revealed that the use of PPIs significantly reduced the risks of GI bleeding.Conclusion: The use of PPIs was associated with a reduced risk of GI bleeding in patients treated with DAPT after percutaneous coronary intervention or acute coronary syndrome. There was no clear evidence of an association between the use of PPIs and adverse cardiovascular events.Clinical Trial Registration: identifier [CRD42020190315]
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- 2021
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17. Agreement in Left Ventricular Function Measured by Echocardiography and Cardiac Magnetic Resonance in Patients With Chronic Coronary Total Occlusion
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Jiahui Li, Lijun Zhang, Yueli Wang, Huijuan Zuo, Rongchong Huang, Xueyao Yang, Ye Han, Yi He, and Xiantao Song
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magnetic resonance imaging ,transthoracic echocardiography ,left ventricular function ,chronic total occlusion ,agreement ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Aims: To determine the agreement between two-dimensional transthoracic echocardiography (2DTTE) and cardiovascular magnetic resonance (CMR) in left ventricular (LV) function [including end-systolic volume (LVESV), end-diastolic volume (LVEDV), and ejection fraction (LVEF)] in chronic total occlusion (CTO) patients.Methods: Eighty-eight CTO patients were enrolled in this study. All patients underwent 2DTTE and CMR within 1 week. The correlation and agreement of LVEF, LVESV, and LVEDV as measured by 2DTTE and CMR were assessed using Pearson correlation, Kappa analysis, and Bland–Altman method.Results: The mean age of patients enrolled was 57 ± 10 years. There was a strong correlation (r = 0.71, 0.90, and 0.80, respectively, all P < 0.001) and a moderately strong agreement (Kappa = 0.62, P < 0.001) between the two modalities in measurement of LV function. The agreement in patients with EF ≧50% was better than in those with an EF
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- 2021
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18. Long-Term Outcomes of Successful Recanalization Compared With Optimal Medical Therapy for Coronary Chronic Total Occlusions in Patients With and Without Left Ventricular Systolic Dysfunction
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Lei Guo, Shaoke Meng, Haichen Lv, Lei Zhong, Jian Wu, Huaiyu Ding, Jiaying Xu, Xiaoyan Zhang, and Rongchong Huang
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chronic total occlusions ,percutaneous coronary intervention ,optimal medical therapy ,left ventricular systolic dysfunction ,LVEF ,outcomes ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: The number of coronary chronic total occlusion (CTO) patients with left ventricular (LV) systolic dysfunction is significant, but the clinical outcomes of these patients are rarely reported. The present retrospective cohort study aimed to investigate the long-term outcomes of successful recanalization vs. optimal medical therapy (MT) for CTOs in patients with preserved and impaired LV systolic function.Methods: A total of 1,895 patients with CTOs were stratified according to LV function. Of these, 1,420 patients (74.9%) with LV ejection fraction (LVEF) >45% and 475 patients (25.1%) with LVEF ≤45% were treated with optimal MT or successful CTO percutaneous coronary intervention (PCI). A 1:1 propensity score matching (PSM) was conducted to reduce the impact of potential confounding on the outcomes. The primary outcome was the frequency of major adverse cardiac events (MACEs).Results: Throughout a 2.6-year follow-up and after adjusting for confounders, among patients with preserved LV function, successful CTO PCI was associated with reduced incidence of MACE (14.2 vs. 23.9%, adjusted HR 0.63, 95% CI 0.48–0.83, p = 0.001) compared to MT. There was no significant difference in MACE occurrence (29.6 vs. 28.9%, adjusted HR 1.05, 95% CI: 0.71–1.56, p = 0.792) between successful recanalization and MT in patients with LV systolic dysfunction. The primary outcome among patients with impaired and preserved LV systolic function after PSM was similar to that from earlier findings before PSM was conducted. A significant interaction between LV function and therapeutic strategy for MACE was observed (interaction p = 0.038).Conclusions: Compared to MT alone for management of patients with CTOs, successful CTO PCI may reduce the risk of MACE in patients with preserved LV systolic function, but not in patients with LV dysfunction.
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- 2021
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19. Corrigendum: Long-Term Outcomes of Successful Revascularization for Patients With Coronary Chronic Total Occlusions: A Report of 1,655 Patients
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Lei Guo, Xiaoyan Zhang, Haichen Lv, Lei Zhong, Jian Wu, Huaiyu Ding, Jiaying Xu, Xuchen Zhou, and Rongchong Huang
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cardiac mortality ,coronary chronic total occlusions ,major adverse cardiac event ,medical therapy ,percutaneous coronary intervention ,successful revascularization ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2021
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20. Corrigendum: Impact of Renal Function on Long-Term Clinical Outcomes in Patients With Coronary Chronic Total Occlusions: Results From an Observational Single-Center Cohort Study During the Last 12 Years
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Lei Guo, Huaiyu Ding, Haichen Lv, Xiaoyan Zhang, Lei Zhong, Jian Wu, Jiaying Xu, Xuchen Zhou, and Rongchong Huang
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chronic total occlusions ,medical therapy ,outcomes ,percutaneous coronary intervention ,renal function ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2021
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21. Impact of Renal Function on Long-Term Clinical Outcomes in Patients With Coronary Chronic Total Occlusions: Results From an Observational Single-Center Cohort Study During the Last 12 Years
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Lei Guo, Huaiyu Ding, Haichen Lv, Xiaoyan Zhang, Lei Zhong, Jian Wu, Jiaying Xu, Xuchen Zhou, and Rongchong Huang
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chronic total occlusions ,medical therapy ,outcomes ,percutaneous coronary intervention ,renal function ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: The number of coronary chronic total occlusion (CTO) patients with renal insufficiency is huge, and limited data are available on the impact of renal insufficiency on long-term clinical outcomes in CTO patients. We aimed to investigate clinical outcomes of CTO percutaneous coronary intervention (PCI) vs. medical therapy (MT) in CTO patients according to baseline renal function.Methods: In the study population of 2,497, 1,220 patients underwent CTO PCI and 1,277 patients received MT. Patients were divided into four groups based on renal function: group 1 [estimated glomerular filtration rate (eGFR) ≥ 90 ml/min/1.73 m2], group 2 (60 ≤ eGFR
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- 2020
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22. Long-Term Outcomes of Successful Revascularization for Patients With Coronary Chronic Total Occlusions: A Report of 1,655 Patients
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Lei Guo, Xiaoyan Zhang, Haichen Lv, Lei Zhong, Jian Wu, Huaiyu Ding, Jiaying Xu, Xuchen Zhou, and Rongchong Huang
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cardiac mortality ,coronary chronic total occlusions ,major adverse cardiac event ,medical therapy ,percutaneous coronary intervention ,successful revascularization ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: To date, the benefit of successful revascularization of chronic total occlusions (CTOs) on prognosis remains uncertain, and there is a paucity of data on the impact of successful revascularization for CTO patients on long-term cardiovascular survival. This study aimed to investigate the long-term cardiovascular survival for patients with successful and unsuccessful CTO revascularization in a large cohort of patients.Methods: There were 1,655 consecutive patients with at least one CTO included and were grouped into successful revascularization (n = 591) and unsuccessful revascularization (n = 1,064). Propensity score matching (PSM) was carried out to balance the clinical and the angiographic characteristics. Cardiac mortality was defined as the primary endpoint. Major adverse cardiac event (MACE) was assessed as a “secondary endpoint.”Results: After 3.6 years of follow-up, there was no significant difference between the successful and the unsuccessful revascularization groups in the rate of cardiac mortality [adjusted hazard ratio (HR) 0.96, 95% confidence interval (CI) 0.59–1.58, p = 0.865]. After the PSM analysis (371 pairs) between the two groups, the cardiac mortality rate values (HR 0.51, 95% CI 0.23–1.15, p = 0.104) were equivalent, whereas the adjusted risk of MACE (HR 0.43, 95% CI 0.32–0.58, p = 0.001) and target-vessel revascularization (HR 0.41, 95% CI 0.29–0.58, p < 0.001) were significantly higher in patients with unsuccessful revascularization.Conclusion: For the treatment of CTO patients, successful revascularization was not associated with a lesser risk for cardiac mortality as compared with unsuccessful revascularization. However, successful revascularization reduced MACE and target-vessel revascularization.
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- 2020
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23. A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation
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Zhishuai Ye, Shanfeng Zhang, Yubo Liu, Shujing Wang, Jianing Zhang, and Rongchong Huang
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Pathology ,RB1-214 - Abstract
Background. Circulating monocytes play a critical role in the pathogenesis of atherosclerosis. Monocyte homing to sites of atherosclerosis is primarily initiated by selectin. Thus, blockade of the interaction of selectins and their ligands holds a significant role in monocyte homing which might be a potential approach to treat atherosclerosis. Here, we investigated the efficacy of a novel peptide analogue of selectin ligands IELLQAR in atherosclerosis. Methods and Results. In this study, we firstly measured the effect of the IELLQAR selectin-binding peptide on the inhibition of binding of selectins to monocytes by flow cytometry, which exhibited a dose-dependent inhibitory effect on the binding of the P-, E-, and L-selectins to monocytes, especially the inhibition of P-selectin binding to human peripheral blood monocytes (PBMCs) (half maximal inhibitory concentration (IC50~5 μM)) and THP-1 cells (IC50~10 μM). Furthermore, IELLQAR inhibited P-selectin-induced activation of CD11b on the surface of monocytes and decreased adhesion of monocytes to the endothelium. ApoE-/- mice with or without IELLQAR (1 or 3 mg/kg) fed a Western-type diet (WTD) or which had disturbed blood flow-induced shear stress underwent partial left carotid artery ligation (PLCA) to induce atherosclerosis. In the WTD- and PLCA-induced atherosclerosis models, atherosclerotic plaque formation and monocyte/macrophage infiltration of the arterial wall both decreased in ApoE-/- mice treated with the IELLQAR peptide. Our results also revealed that IELLQAR inhibited the differentiation of monocytes into macrophages through P-selectin-dependent activation of the nuclear factor- (NF-) κB and mammalian target of rapamycin (mTOR) pathways. Conclusion. Collectively, our results demonstrated that IELLQAR, a peptide analogue of selectin ligands, inhibited selectin binding to monocytes, which led to subsequent attenuation of atherosclerosis via inhibition of monocyte activation. Hence, use of the IELLQAR peptide provides a new approach and represents a promising candidate for the treatment of atherosclerosis in the early stage of disease.
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- 2019
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24. Gender Differences in Long-Term Outcomes of Medical Therapy and Successful Percutaneous Coronary Intervention for Coronary Chronic Total Occlusions
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Lei Guo, Haichen Lv, Lei Zhong, Jian Wu, Huaiyu Ding, Jiaying Xu, and Rongchong Huang
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background. There is a paucity of information about the gender differences in clinical outcomes of successful percutaneous coronary intervention (PCI) compared with medical therapy (MT) in patients with coronary chronic total occlusions (CTOs). Objectives. We aimed to investigate the impact of gender on long-term clinical outcomes associated with successful CTO-PCI versus MT in patients with CTOs. Methods. Between January 2007 and December 2016, a total of 1702 patients with ≥1 CTO were enrolled. After exclusion, 1294 patients with 1520 CTOs were analyzed and were divided into the female group (n = 304, 23.5%) and the male group (n = 990, 76.5%). The patients in the female or male group were assigned to a MT group or successful CTO-PCI group according to the treatment strategy. In the female group, they were divided into two groups: 177 patients in the MT group and 127 patients in the successful CTO-PCI group. In the male group, they were divided into two groups: 623 patients in the MT group and 367 patients in the successful CTO-PCI group. The primary outcome was cardiac death. The secondary outcome was major adverse cardiac event (MACE). Results. The median overall follow-up duration was 3.6 (IQR, 2.1–5.0) years, there were no significant differences between the MT and successful CTO-PCI groups with respect to the prevalence of cardiac death (MT vs. successful PCI: 6.8% vs. 3.9%, p=0.287) and MACE (20.9% vs. 21.3%, p=0.810) in female patients. In the male group, the occurrence of cardiac death (MT vs. successful PCI: 6.6% vs. 3.8%, p=0.066) was similar between the two groups. The MACE rate (30.0% vs. 18.5%, p
- Published
- 2019
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25. Correction to: Long‑term outcomes of medical therapy versus successful recanalisation for coronary chronic total occlusions in patients with and without type 2 diabetes mellitus
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Lei Guo, Junjie Wang, Huaiyu Ding, Shaoke Meng, Xiaoyan Zhang, Haichen Lv, Lei Zhong, Jian Wu, Jiaying Xu, Xuchen Zhou, and Rongchong Huang
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
An amendment to this paper has been published and can be accessed via the original article.
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- 2021
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26. Association between novel inflammatory markers and non-alcoholic fatty liver disease: a cross-sectional study.
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Gang Wang, Yu Zhao, Zeya Li, Dan Li, Feng Zhao, Jing Hao, Chunlei Yang, Jiashu Song, Xianzhong Gu, and Rongchong Huang
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- 2024
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27. Long-term outcomes of medical therapy versus successful recanalisation for coronary chronic total occlusions in patients with and without type 2 diabetes mellitus
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Jun-Jie Wang, Huaiyu Ding, Rongchong Huang, Lei Guo, Jian Wu, Jiaying Xu, Shaoke Meng, Xuchen Zhou, Haichen Lv, Xiaoyan Zhang, and Lei Zhong
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medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Medical therapy ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Outcomes ,Percutaneous coronary intervention ,Diabetes mellitus ,Internal medicine ,medicine ,cardiovascular diseases ,Chronic total occlusions ,Original Investigation ,business.industry ,Incidence (epidemiology) ,Hazard ratio ,Diabetes ,medicine.disease ,Confidence interval ,lcsh:RC666-701 ,Propensity score matching ,Conventional PCI ,Cardiology and Cardiovascular Medicine ,business ,Mace - Abstract
Background In this study, we compared the outcomes of medical therapy (MT) with successful percutaneous coronary intervention (PCI) in chronic total occlusions (CTO) patients with and without type 2 diabetes mellitus. Methods A total of 2015 patients with CTOs were stratified. Diabetic patients (n = 755, 37.5%) and non-diabetic patients (n = 1260, 62.5%) were subjected to medical therapy or successful CTO-PCI. We performed a propensity score matching (PSM) to balance the baseline characteristics. A comparison of the major adverse cardiac events (MACE) was done to evaluate long-term outcomes. Results The median follow-up duration was 2.6 years. Through multivariate analysis, the incidence of MACE was significantly higher among diabetic patients compared to the non-diabetic patients (adjusted hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.09–1.61, p = 0.005). Among the diabetic group, the rate of MACE (adjusted HR 0.61, 95% CI 0.42–0.87, p = 0.006) was significantly lower in the successful CTO-PCI group than in the MT group. Besides, in the non-diabetic group, the prevalence of MACE (adjusted HR 0.85, 95% CI 0.64–1.15, p = 0.294) and cardiac death (adjusted HR 0.94, 95% CI 0.51–1.70, p = 0.825) were comparable between the two groups. Similar results as with the early detection were obtained in propensity-matched diabetic and non-diabetic patients. Notably, there was a significant interaction between diabetic or non-diabetic with the therapeutic strategy on MACE (p for interaction = 0.036). Conclusions For treatment of CTO, successful CTO-PCI highly reduces the risk of MACE in diabetic patients when compared with medical therapy. However, this does not apply to non-diabetic patients.
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- 2020
28. Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review
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Rongchong Huang, Jinfan Tian, Xin Zhao, Min Zhang, Mohammad Sharif Popal, Xiantao Song, and Mingduo Zhang
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0301 basic medicine ,autophagy ,Caveolin ,Review Article ,Pathology and Forensic Medicine ,Nitric oxide ,target ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,cardiovascular disease ,Caveolae ,Medicine ,business.industry ,Autophagy ,Cell Biology ,Cell biology ,Crosstalk (biology) ,030104 developmental biology ,chemistry ,role ,Neurology (clinical) ,Geriatrics and Gerontology ,Signal transduction ,business ,030217 neurology & neurosurgery ,Biogenesis ,Homeostasis - Abstract
Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.
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- 2020
29. Safety of low-dose dobutamine stress test in coronary slow flow phenomenon
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Jian Wu, Rongchong Huang, Shuang Meng, and Yanzong Yang
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Pharmaceutical Science ,Pharmacology (medical) ,cardiovascular diseases ,Coronary slow flow phenomenon, Dobutamine stress test, Echocardiography, Tachycardia, Malignant arrhythmia, Ventricular fibrillation - Abstract
Purpose: To investigate the feasibility and safety of a low-dose dobutamine stress test in coronary slow flow phenomenon (CSFP) patients.Methods: One hundred and forty-two CSFP patients, and forty-four patients without CSFP or significant epicardial coronary stenosis who served as the control group, were retrospectively reviewed. All patients were infused intravenously with dobutamine at an initial infusion rate of 5 μg/kg/min which was then increased at 8-min intervals to 10, 15, and 20 μg/kg/min. Symptoms and echocardiography were monitored simultaneously.Results: Patient tolerance decreased as the doses of dobutamine increased. No termination of the test occurred without dobutamine or at the infusion rate of 5 μg/kg/min. Nonetheless, when the infusion rates were adjusted to 15 and 20 μg/kg/min, the incident of side effects reached up to 30.9 %, and a few patients experienced ST-segment depression in precordial electrocardiographic leads. There were no induced arrhythmias without dobutamine, while the incidence of arrhythmias was highest at the infusion rate of 20 μg/kg/min. Malignant arrhythmias such as ventricular fibrillation and sustained ventricular tachycardia, were not detected. No significant differences were showed in echocardiogram result for left ventricular ejection fraction (LVEF) between CSFP and control group (63.7±7.9 in the CSFP group, versus 64.3±7.2 in the control group; p = 0.63).Conclusion: A low-dose dobutamine stress test is safe and feasible in CSFP patients.
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- 2021
30. Agreement in Left Ventricular Function Measured by Echocardiography and Cardiac Magnetic Resonance in Patients With Chronic Coronary Total Occlusion
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Lijun Zhang, Xueyao Yang, Xiantao Song, Rongchong Huang, Huijuan Zuo, Yi He, Ye Han, Jiahui Li, and Yueli Wang
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medicine.medical_specialty ,030204 cardiovascular system & hematology ,Cardiovascular Medicine ,Total occlusion ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,transthoracic echocardiography ,left ventricular function ,0302 clinical medicine ,Internal medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,magnetic resonance imaging ,In patient ,Wall motion ,cardiovascular diseases ,chronic total occlusion ,Original Research ,Ejection fraction ,medicine.diagnostic_test ,Ventricular function ,business.industry ,Magnetic resonance imaging ,RC666-701 ,Cardiology ,cardiovascular system ,Cardiology and Cardiovascular Medicine ,business ,Cardiac magnetic resonance ,agreement ,Kappa - Abstract
Aims: To determine the agreement between two-dimensional transthoracic echocardiography (2DTTE) and cardiovascular magnetic resonance (CMR) in left ventricular (LV) function [including end-systolic volume (LVESV), end-diastolic volume (LVEDV), and ejection fraction (LVEF)] in chronic total occlusion (CTO) patients.Methods: Eighty-eight CTO patients were enrolled in this study. All patients underwent 2DTTE and CMR within 1 week. The correlation and agreement of LVEF, LVESV, and LVEDV as measured by 2DTTE and CMR were assessed using Pearson correlation, Kappa analysis, and Bland–Altman method.Results: The mean age of patients enrolled was 57 ± 10 years. There was a strong correlation (r = 0.71, 0.90, and 0.80, respectively, all P < 0.001) and a moderately strong agreement (Kappa = 0.62, P < 0.001) between the two modalities in measurement of LV function. The agreement in patients with EF ≧50% was better than in those with an EF r = 0.84, 0.96, and 0.87, respectively) and smaller biases in LV function measurement.Conclusions: The difference in measurement between 2DTTE and CMR should be noticed in CTO patients with EF
- Published
- 2021
31. Long-Term Outcomes of Successful Recanalization Compared With Optimal Medical Therapy for Coronary Chronic Total Occlusions in Patients With and Without Left Ventricular Systolic Dysfunction
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Huaiyu Ding, Shaoke Meng, Lei Zhong, Haichen Lv, Xiaoyan Zhang, Lei Guo, Jiaying Xu, Jian Wu, and Rongchong Huang
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medicine.medical_specialty ,LVEF ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Cardiovascular Medicine ,outcomes ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,030212 general & internal medicine ,cardiovascular diseases ,Original Research ,Ejection fraction ,business.industry ,Incidence (epidemiology) ,Confounding ,percutaneous coronary intervention ,Percutaneous coronary intervention ,Retrospective cohort study ,optimal medical therapy ,RC666-701 ,chronic total occlusions ,Conventional PCI ,Propensity score matching ,Cardiology ,business ,Cardiology and Cardiovascular Medicine ,Mace ,left ventricular systolic dysfunction - Abstract
Background: The number of coronary chronic total occlusion (CTO) patients with left ventricular (LV) systolic dysfunction is significant, but the clinical outcomes of these patients are rarely reported. The present retrospective cohort study aimed to investigate the long-term outcomes of successful recanalization vs. optimal medical therapy (MT) for CTOs in patients with preserved and impaired LV systolic function.Methods: A total of 1,895 patients with CTOs were stratified according to LV function. Of these, 1,420 patients (74.9%) with LV ejection fraction (LVEF) >45% and 475 patients (25.1%) with LVEF ≤45% were treated with optimal MT or successful CTO percutaneous coronary intervention (PCI). A 1:1 propensity score matching (PSM) was conducted to reduce the impact of potential confounding on the outcomes. The primary outcome was the frequency of major adverse cardiac events (MACEs).Results: Throughout a 2.6-year follow-up and after adjusting for confounders, among patients with preserved LV function, successful CTO PCI was associated with reduced incidence of MACE (14.2 vs. 23.9%, adjusted HR 0.63, 95% CI 0.48–0.83, p = 0.001) compared to MT. There was no significant difference in MACE occurrence (29.6 vs. 28.9%, adjusted HR 1.05, 95% CI: 0.71–1.56, p = 0.792) between successful recanalization and MT in patients with LV systolic dysfunction. The primary outcome among patients with impaired and preserved LV systolic function after PSM was similar to that from earlier findings before PSM was conducted. A significant interaction between LV function and therapeutic strategy for MACE was observed (interaction p = 0.038).Conclusions: Compared to MT alone for management of patients with CTOs, successful CTO PCI may reduce the risk of MACE in patients with preserved LV systolic function, but not in patients with LV dysfunction.
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- 2021
32. The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway
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Lei Zhong, Jie Zheng, Shujing Wang, Rongchong Huang, Zhishuai Ye, Jianing Zhang, Shengnan Zhu, and Yinuo Wang
- Subjects
Male ,0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,P-selectin ,Immunology ,Stimulation ,030204 cardiovascular system & hematology ,Article ,Proinflammatory cytokine ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Apolipoproteins E ,0302 clinical medicine ,In vivo ,Internal medicine ,Cell death and immune response ,medicine ,Animals ,Humans ,lcsh:QH573-671 ,Receptor ,Aged ,Mice, Knockout ,Membrane Glycoproteins ,Chemistry ,lcsh:Cytology ,Dendritic Cells ,Cell Biology ,Middle Aged ,Atherosclerosis ,Toll-Like Receptor 4 ,P-Selectin ,030104 developmental biology ,Endocrinology ,Myeloid Differentiation Factor 88 ,Knockout mouse ,TLR4 ,Female ,B7-2 Antigen ,Signal transduction ,Signal Transduction - Abstract
P-selectin and dendritic cells (DCs) are associated with atherosclerosis. However, their interactions in this setting are undefined. Herein, we investigated the role of P-selectin and its receptor P-selectin glycoprotein ligand (PSGL)-1 on atherosclerosis via activation of DCs. In the current study, a total of 34 patients with ST elevation myocardial infarction (STEMI) and 34 healthy control subjects were enrolled. Serum concentration of P-selectin was higher and the myeloid DC/plasmacytoid DC (mDC/pDC) ratio was lower in STEMI patients than in normal individuals. Interestingly, in STEMI patients, P-selectin was decreased and the mDC/pDC ratio was increased at 5–7 days after successful percutaneous coronary intervention, as compared with values on admission. Serum P-selectin was inversely correlated with the mDC/pDC ratio. Moreover, ApoE−/−P−/− and ApoE−/−PSGL-1−/− mice developed small atherosclerotic plaques after feeding of a western diet for 12 weeks and DC infiltration was significantly reduced. P-selectin stimulation markedly induced phenotypic maturation, enhanced secretion of inflammatory cytokines, communication with T cells, and the adhesion and migration of DCs. In vivo, DC maturation was significantly attenuated in P-selectin and PSGL1 knockout mice under hypercholesterolemic and inflammatory conditions. These effects were associated with the activation of myeloid differentiation primary response 88 (MYD88)-dependent and MyD88-independent Toll-like receptor 4 (TLR4) signaling pathways. Taken together, binding of P-selectin to PSGL-1 on DCs contributes to atherosclerosis progression via DC activation via the TLR4 signaling pathway.
- Published
- 2019
33. Preferences and attitudes of young Chinese clinicians about using a shared decision making tools for communicating cardiovascular risk
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Dongfeng Zhang, Michael R. Gionfriddo, Kasey R. Boehmer, Henry H. Ting, Victor M. Montori, Xiantao Song, Aaron A. Leppin, Jia-ying Xu, and Rongchong Huang
- Subjects
medicine.medical_specialty ,Medicine (General) ,China ,business.industry ,Sample (statistics) ,030204 cardiovascular system & hematology ,Logistic regression ,Cardiovascular risk ,Preference ,3. Good health ,Test (assessment) ,03 medical and health sciences ,0302 clinical medicine ,R5-920 ,Decision aid ,Current practice ,030220 oncology & carcinogenesis ,Intervention (counseling) ,Family medicine ,Decision aids ,Medicine ,Original Article ,business ,Shared-decision making - Abstract
Objective: This study assesses the attitudes and preferences of Chinese clinicians toward their involvement in shared decision making (SDM). Methods: From May 2014 to May 2015, 200 Chinese clinicians from two hospitals were enrolled to complete a survey on their attitude towards SDM. We conducted the survey via face-to-face interviews before and after an educational intervention on SDM among young Chinese clinicians. The clinicians were asked to give the extent of agreement to SDM. They also gave the extent of difficulty in using decision aids (DAs) during the SDM process. The variation in the range of responses to each question before and after the SDM intervention was recorded. The frequency of changed responses was analyzed by using JMP 6.0 software. Data were statistically analyzed using Chi-square and Mann-Whitney U tests, as appropriate to the data type. Multiple logistic regressions were used to test for those factors significantly and independently associated with preference for an approach for each scenario. Results: Of the 200 young Chinese clinicians sampled, 59.0% indicated a preference for SDM and a desire to participate in SDM before receiving education or seeing the DA, and this number increased to 69.0% after seeing the DA with the sample video of the SDM process on Statin Choice. However, 28.5% of the respondents still reported that, in their current practice, they make clinical decisions on behalf of their patients. The clinicians who denied a desire to use the DA stated that the main barriers to implement SDM or DA use in China are lack of time and knowledge of SDM. Conclusions: Most young Chinese clinicians want to participate in SDM. However, they state the main barriers to perform SDM are lack of experience and time. The educational intervention about SDM that exposes clinicians to DAs was found to increase their receptivity. Key words: Decision aid; Shared-decision making; Cardiovascular risk; China
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- 2019
34. Differences in the cargos and functions of exosomes derived from six cardiac cell types: a systematic review
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Zhishuai Ye, Mingyue Xu, Rongchong Huang, and Xian-tao Song
- Subjects
0301 basic medicine ,Cardiac function curve ,Angiogenesis ,Medicine (miscellaneous) ,Review ,Biology ,Exosomes ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,lcsh:Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,microRNA ,Animals ,Humans ,Myocytes, Cardiac ,lcsh:QD415-436 ,lcsh:R5-920 ,Regeneration (biology) ,Cardiovascular disease (CVD) ,Cell migration ,MicroRNA ,Cardiac cells ,Cell Biology ,Fibroblasts ,Microvesicles ,Cell biology ,MicroRNAs ,030104 developmental biology ,Cardiovascular Diseases ,Apoptosis ,030220 oncology & carcinogenesis ,cardiovascular system ,Molecular Medicine ,Stem cell ,lcsh:Medicine (General) - Abstract
Exosomes are bilayer membrane vesicles with cargos that contain a variety of surface proteins, markers, lipids, nucleic acids, and noncoding RNAs. Exosomes from different cardiac cells participate in the processes of cell migration, proliferation, apoptosis, hypertrophy, and regeneration, as well as angiogenesis and enhanced cardiac function, which accelerate cardiac repair. In this article, we mainly focused on the exosomes from six main types of cardiac cells, i.e., fibroblasts, cardiomyocytes, endothelial cells, cardiac progenitor cells, adipocytes, and cardiac telocytes. This may be the first article to describe the commonalities and differences in regard to the function and underlying mechanisms of exosomes among six cardiac cell types in cardiovascular disease.
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- 2019
35. Corrigendum: Long-Term Outcomes of Successful Revascularization for Patients With Coronary Chronic Total Occlusions: A Report of 1,655 Patients
- Author
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Haichen Lv, Xiaoyan Zhang, Jian Wu, Xuchen Zhou, Rongchong Huang, Lei Zhong, Huaiyu Ding, Lei Guo, and Jiaying Xu
- Subjects
0301 basic medicine ,cardiac mortality ,medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Revascularization ,03 medical and health sciences ,0302 clinical medicine ,successful revascularization ,Internal medicine ,medicine ,Clinical endpoint ,Long term outcomes ,business.industry ,Hazard ratio ,percutaneous coronary intervention ,Percutaneous coronary intervention ,coronary chronic total occlusions ,Confidence interval ,medical therapy ,030104 developmental biology ,lcsh:RC666-701 ,major adverse cardiac event ,Propensity score matching ,Cardiology ,business ,Cardiology and Cardiovascular Medicine ,Mace - Abstract
Background: To date, the benefit of successful revascularization of chronic total occlusions (CTOs) on prognosis remains uncertain, and there is a paucity of data on the impact of successful revascularization for CTO patients on long-term cardiovascular survival. This study aimed to investigate the long-term cardiovascular survival for patients with successful and unsuccessful CTO revascularization in a large cohort of patients. Methods: There were 1,655 consecutive patients with at least one CTO included and were grouped into successful revascularization (n = 591) and unsuccessful revascularization (n = 1,064). Propensity score matching (PSM) was carried out to balance the clinical and the angiographic characteristics. Cardiac mortality was defined as the primary endpoint. Major adverse cardiac event (MACE) was assessed as a "secondary endpoint." Results: After 3.6 years of follow-up, there was no significant difference between the successful and the unsuccessful revascularization groups in the rate of cardiac mortality [adjusted hazard ratio (HR) 0.96, 95% confidence interval (CI) 0.59-1.58, p = 0.865]. After the PSM analysis (371 pairs) between the two groups, the cardiac mortality rate values (HR 0.51, 95% CI 0.23-1.15, p = 0.104) were equivalent, whereas the adjusted risk of MACE (HR 0.43, 95% CI 0.32-0.58, p = 0.001) and target-vessel revascularization (HR 0.41, 95% CI 0.29-0.58, p < 0.001) were significantly higher in patients with unsuccessful revascularization. Conclusion: For the treatment of CTO patients, successful revascularization was not associated with a lesser risk for cardiac mortality as compared with unsuccessful revascularization. However, successful revascularization reduced MACE and target-vessel revascularization.
- Published
- 2021
36. Long-term clinical outcomes of optimal medical therapy vs. successful percutaneous coronary intervention for patients with coronary chronic total occlusions
- Author
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Jian Wu, Kun Chen, Lei Zhong, Rongchong Huang, and Lei Guo
- Subjects
Male ,medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Multivariate analysis ,medicine.medical_treatment ,Population ,Myocardial Infarction ,030204 cardiovascular system & hematology ,Revascularization ,Coronary Angiography ,03 medical and health sciences ,0302 clinical medicine ,Percutaneous Coronary Intervention ,Recurrence ,Internal medicine ,medicine ,Myocardial Revascularization ,Prevalence ,Humans ,030212 general & internal medicine ,cardiovascular diseases ,education ,Aged ,education.field_of_study ,business.industry ,Hazard ratio ,Percutaneous coronary intervention ,Middle Aged ,Confidence interval ,Death ,Treatment Outcome ,Coronary Occlusion ,lcsh:RC666-701 ,Conventional PCI ,Chronic Disease ,Female ,Cardiology and Cardiovascular Medicine ,business ,Mace - Abstract
Objectives: There are little data on the long-term clinical outcomes of optimal medical therapy (OMT) compared with successful percutaneous coronary intervention (PCI) in patients with chronic total occlusions (CTOs). Methods: A total of 388 patients with ≥1 CTO were enrolled from January 2008 to December 2010. 62 patients were excluded, and 326 patients were divided into an OMT group (n = 125) and PCI group (n = 201) according to the initial treatment strategy. Propensity-score matching was also done to adjust for baseline characteristics. The primary outcome was major adverse cardiac event (MACE), included cardiac death, recurrent myocardial infarction, and repeated revascularization. Results: After a mean follow-up of 47.2 ± 20.0 months, there was no significant difference between the two groups with respect to the prevalence of MACE (successful PCI vs. OMT: 29.6% vs. 21.9%, unadjusted hazard ratio [HR] 1.47, 95% confidence interval [CI] 0.95–2.28, p=0.085). After multivariate analyses, there were significant differences in the prevalence of MACE (adjusted HR 1.76, 95% CI 1.09–2.28, p=0.02) and repeated revascularization (2.14; 1.18–3.90, 0.01). In the propensity score-matched population (80 pairs), there were no significant differences in the prevalence of MACE (adjusted HR 1.89, 95% CI 0.96–3.71, p=0.06) and cardiac death (1.30, 0.44–3.80, 0.63) between groups. Conclusion: In the treatment of patients with CTOs, successful PCI did not reduce the long-term risk of MACE compared with OMT. Keywords: Chronic total occlusions, Percutaneous coronary intervention, Optimal medical therapy, Outcome
- Published
- 2018
37. Selectins modify dendritic cells during atherosclerosis
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Rongchong Huang and Zhi-Shuai Ye
- Subjects
0301 basic medicine ,Medicine (General) ,business.industry ,Immune tolerance ,hemic and immune systems ,chemical and pharmacologic phenomena ,Hematopoietic lineage ,Atherosclerosis ,Phenotype ,Dendritic cells ,Cell biology ,03 medical and health sciences ,R5-920 ,030104 developmental biology ,Immune system ,T cell subset ,Perspective ,Selectins ,Medicine ,business ,Immunologic Tolerance ,Selectin ,Function (biology) - Abstract
Dendritic cells (DCs) are professional antigen-presenting cells (APC) that facilitate the development and progression of atherosclerosis. However, DCs also function as novel “switches” between immune activation and immune tolerance and represent a heterogeneous hematopoietic lineage, with cell subsets in different tissues that show a differential morphology, phenotype, and function. Regulatory DCs, depending on their immature state, can be induced by immunosuppressive modulation, which plays an important part in the maintenance of immunologic tolerance via suppression of the immune response. In this review, we describe the current understanding of the generation of regulatory DCs. The novel role of selectins in the modification of DCs in atherosclerosis is also discussed. Keywords: Dendritic cells, Selectins, Atherosclerosis, Immune tolerance
- Published
- 2018
38. Tenascin-C promotes the migration of bone marrow stem cells via toll-like receptor 4-mediated signaling pathways: MAPK, AKT and Wnt
- Author
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Dai Liu, Mingyu Jin, Rongchong Huang, Huaiyu Ding, Shujing Wang, Jianing Zhang, and Xiantao Song
- Subjects
0301 basic medicine ,MAPK/ERK pathway ,Male ,Cancer Research ,Cell Survival ,Bone Marrow Cells ,bone marrow stem cells ,Biochemistry ,03 medical and health sciences ,Mice ,stomatognathic system ,Cell Movement ,Genetics ,Animals ,tenascin-c ,Protein kinase A ,Molecular Biology ,Protein kinase B ,Cell Proliferation ,biology ,Chemistry ,Stem Cells ,Tenascin C ,Wnt signaling pathway ,Bone Marrow Stem Cell ,hemic and immune systems ,Cell Differentiation ,Tenascin ,Articles ,Cell biology ,Transplantation ,Toll-Like Receptor 4 ,Wnt Proteins ,030104 developmental biology ,myocardial infarction ,Phenotype ,Oncology ,biology.protein ,Molecular Medicine ,Signal transduction ,homing ,Mitogen-Activated Protein Kinases ,Proto-Oncogene Proteins c-akt ,Biomarkers ,Signal Transduction - Abstract
There are currently limitations in stem cell therapy due to the low rate of homing and proliferation of cells following transplantation. The present study was designed to investigate the effects of Tenascin‑C (TN‑C) on bone marrow mesenchymal stem cells (BMSCs) and its underlying mechanisms. BMSCs were obtained from C57BL/6 mice. The survival and proliferation of BMSCs was analyzed by Cell Counting Kit‑8 assay, migration was evaluated using the Transwell method, and differentiation was assessed by immunocytochemistry and immunofluorescence. In addition, the levels of proteins were detected by western blotting. High concentrations of TN‑C promoted the migration of BMSCs. H2O2 at concentrations of 60‑90 µmol/ml induced cell death in BMSCs, and thus, it was used to simulate oxidative stress in the microenvironment of acute myocardial infarction (AMI). High concentrations of TN‑C were able to protect BMSCs from cell death, and promoted the migration of BMSCs (P
- Published
- 2018
39. Evaluation of Early Biomarkers of Atherosclerosis Associated with Polychlorinated Biphenyl Exposure: An in Vitro and in Vivo Study.
- Author
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Bingwei Yang, Zhishuai Ye, Yawen Wang, Hongzhou Guo, Lehmler, Hans-Joachim, Rongchong Huang, Erqun Song, and Yang Song
- Subjects
BIOMARKERS ,IN vitro studies ,ENDOTHELIAL cells ,REVERSE transcriptase polymerase chain reaction ,POLLUTANTS ,IN vivo studies ,PRECIPITIN tests ,ATHEROSCLEROSIS ,CELL survival ,DESCRIPTIVE statistics ,MESSENGER RNA ,POLYMERASE chain reaction ,BIOLOGICAL assay ,POLYCHLORINATED biphenyls ,ENVIRONMENTAL exposure - Abstract
BACKGROUND: Miscellaneous cardiovascular risk factors have been defined, but the contribution of environmental pollutants exposure on cardiovascular disease (CVD) remains underappreciated. OBJECTIVE: We investigated the potential impact of typical environmental pollutant exposure on atherogenesis and its underlying mechanisms. METHODS: We used human umbilical vein endothelial cells (HUVECs) and apolipoprotein E knockout (ApoE
-/- ) mice to investigate how 2,3,5-trichloro-6-phenyl-[1,4]-benzoquinone (PCB29-pQ, a toxic polychlorinated biphenyl metabolite) affects atherogenesis and identified early biomarkers of CVD associated with PCB29-pQ exposures. Then, we used long noncoding RNAs (lncRNAs) HDAC7-AS1–overexpressing ApoE-/- mice and apolipoprotein E/caveolin 1 double-knockout (ApoE-/- /CAV1-/- ) mice to address the role of these early biomarkers in PCB29-pQ–induced atherogenesis. Plasma samples from patients with coronary heart disease (CHD) were also used to confirm our findings. RESULTS: Our data indicate that lncRNA HDAC7-AS1 bound to MIR-7-5p via argonaute 2 in PCB29-pQ–challenged HUVECs. Our mRNA sequencing assay identified transforming growth factor-β2 (TGF-β2) as a possible target gene of MIR-7-5p; HDAC7-AS1 sponged MIR-7-5p and inhibited the binding of TGF-β2 to MIR-7-5p. The effect of PCB29-pQ–induced endothelial injury, vascular inflammation, development of plaques, and atherogenesis in ApoE-/- mice was greater with MIR-7-5p–mediated TGF-β2 inhibition, whereas HDAC7-AS1–overexpressing ApoE-/- mice and ApoE-/- /CAV1-/- mice showed the opposite effect. Consistently, plasma levels of HDAC7-AS1 and MIR-7-5p were found to be significantly associated individuals diagnosed with CHD. DISCUSSIONS: These findings demonstrated that a mechanism-based, integrated-omics approach enabled the identification of potentially clinically relevant diagnostic indicators and therapeutic targets of CHD mediated by environmental contaminants using in vitro and in vivo models of HUVECs and ApoE-/- and ApoE-/- /CAV1-/- mice. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
40. Serum apolipoprotein A-I depletion is causative to silica nanoparticles–induced cardiovascular damage.
- Author
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Xuting Liu, Wei Wei, Zixuan Liu, Erqun Song, Jianlin Lou, Lingfang Feng, Rongchong Huang, Chunying Chen, Pu Chun Ke, and Yang Song
- Subjects
SILICA nanoparticles ,CARDIOVASCULAR system ,CARDIAC patients ,CORONARY disease ,PULMONARY surfactant ,COMMERCIAL products - Abstract
The rapid development of nanotechnology has greatly benefited modern science and engineering and also led to an increased environmental exposure to nanoparticles (NPs). While recent research has established a correlation between the exposure of NPs and cardiovascular diseases, the intrinsic mechanisms of such a connection remain unclear. Inhaled NPs can penetrate the air–blood barrier from the lung to systemic circulation, thereby intruding the cardiovascular system and generating cardiotoxic effects. In this study, on-site cardiovascular damage was observed in mice upon respiratory exposure of silica nanoparticles (SiNPs), and the corresponding mechanism was investigated by focusing on the interaction of SiNPs and their encountered biomacromolecules en route. SiNPs were found to collect a significant amount of apolipoprotein A-I (Apo A-I) from the blood, in particular when the SiNPs were preadsorbed with pulmonary surfactants. While the adsorbed Apo A-I ameliorated the cytotoxic and proinflammatory effects of SiNPs, the protein was eliminated from the blood upon clearance of the NPs. However, supplementation of Apo A-I mimic peptide mitigated the atherosclerotic lesion induced by SiNPs. In addition, we found a further declined plasma Apo A-I level in clinical silicosis patients than coronary heart disease patients, suggesting clearance of SiNPs sequestered Apo A-I to compromise the coronal protein’s regular biological functions. Together, this study has provided evidence that the protein corona of SiNPs acquired in the blood depletes Apo A-I, a biomarker for prediction of cardiovascular diseases, which gives rise to unexpected toxic effects of the nanoparticles. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
41. A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation
- Author
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Shujing Wang, Zhishuai Ye, Yubo Liu, Shanfeng Zhang, Jianing Zhang, and Rongchong Huang
- Subjects
0301 basic medicine ,Male ,Article Subject ,Endothelium ,THP-1 Cells ,Immunology ,Pharmacology ,Peripheral blood mononuclear cell ,Monocytes ,Flow cytometry ,Pathogenesis ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Apolipoproteins E ,medicine ,lcsh:Pathology ,Animals ,Humans ,PI3K/AKT/mTOR pathway ,Triglycerides ,biology ,medicine.diagnostic_test ,Chemistry ,Monocyte ,Cell Biology ,Atherosclerosis ,Lipoproteins, LDL ,030104 developmental biology ,medicine.anatomical_structure ,Cholesterol ,Integrin alpha M ,030220 oncology & carcinogenesis ,biology.protein ,Selectins ,Lipoproteins, HDL ,Peptides ,Selectin ,Research Article ,lcsh:RB1-214 - Abstract
Background. Circulating monocytes play a critical role in the pathogenesis of atherosclerosis. Monocyte homing to sites of atherosclerosis is primarily initiated by selectin. Thus, blockade of the interaction of selectins and their ligands holds a significant role in monocyte homing which might be a potential approach to treat atherosclerosis. Here, we investigated the efficacy of a novel peptide analogue of selectin ligands IELLQAR in atherosclerosis. Methods and Results. In this study, we firstly measured the effect of the IELLQAR selectin-binding peptide on the inhibition of binding of selectins to monocytes by flow cytometry, which exhibited a dose-dependent inhibitory effect on the binding of the P-, E-, and L-selectins to monocytes, especially the inhibition of P-selectin binding to human peripheral blood monocytes (PBMCs) (half maximal inhibitory concentration (IC50~5 μM)) and THP-1 cells (IC50~10 μM). Furthermore, IELLQAR inhibited P-selectin-induced activation of CD11b on the surface of monocytes and decreased adhesion of monocytes to the endothelium. ApoE-/- mice with or without IELLQAR (1 or 3 mg/kg) fed a Western-type diet (WTD) or which had disturbed blood flow-induced shear stress underwent partial left carotid artery ligation (PLCA) to induce atherosclerosis. In the WTD- and PLCA-induced atherosclerosis models, atherosclerotic plaque formation and monocyte/macrophage infiltration of the arterial wall both decreased in ApoE-/- mice treated with the IELLQAR peptide. Our results also revealed that IELLQAR inhibited the differentiation of monocytes into macrophages through P-selectin-dependent activation of the nuclear factor- (NF-) κB and mammalian target of rapamycin (mTOR) pathways. Conclusion. Collectively, our results demonstrated that IELLQAR, a peptide analogue of selectin ligands, inhibited selectin binding to monocytes, which led to subsequent attenuation of atherosclerosis via inhibition of monocyte activation. Hence, use of the IELLQAR peptide provides a new approach and represents a promising candidate for the treatment of atherosclerosis in the early stage of disease.
- Published
- 2019
42. Stem cell transplantation dose in patients with acute myocardial infarction: A meta-analysis
- Author
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Ming Tian, Dai Liu, Wen-Yuan Cai, Jia-ying Xu, and Rongchong Huang
- Subjects
Left ventricular ejection fraction ,medicine.medical_specialty ,Medicine (General) ,medicine.medical_treatment ,Acute myocardial infarction ,Cell dosage ,030204 cardiovascular system & hematology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,R5-920 ,Randomized controlled trial ,law ,Internal medicine ,medicine ,030212 general & internal medicine ,Myocardial infarction ,Stem cell ,Ejection fraction ,business.industry ,Meta Analysis ,Stem-cell therapy ,medicine.disease ,Confidence interval ,Surgery ,Transplantation ,Meta-analysis ,business - Abstract
Objective: To evaluate whether stem cell transplantation improves global left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI), and to determine the appropriate stem cell therapy dose as well as the effective period after stem cell transplantation for therapy. Methods: A systematic literature search included Pubmed, MEDLINE, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and Cochrane Evidence-Based Medicine databases. The retrieval time limit ranged from January 1990 to June 2016. We also obtained full texts through manual retrieval, interlibrary loan and document delivery service, or by contacting the authors directly. According to our inclusion and exclusion criteria, data were extracted independently by two evaluators. In case of disagreement, a joint discussion occurred and a third researcher was utilized. Data were analyzed quantitatively using Revman 5.2. Summary results are presented as the weighted mean difference (WMD) with 95% confidence intervals (CIs). We collected individual trial data and conducted a meta-analysis to compare changes in global left ventricular ejection fraction (ÎLVEF) after stem cell therapy. In this study, four subgroups were based on stem cell dose (â¤1 Ã 107 cells, â¤1 Ã 108 cells, â¤1 Ã 109 cells, and â¤1 Ã 1010 cells) and three subgroups were based on follow-up time (
- Published
- 2016
43. CT Angiography-Derived RECHARGE Score Predicts Successful Percutaneous Coronary Intervention in Patients with Chronic Total Occlusion.
- Author
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Jiahui Li, Rui Wang, Tesche, Christian, Schoepf, U. Joseph, Pannell, Jonathan T., Yi He, Rongchong Huang, Yalei Chen, Jianan Li, and Xiantao Song
- Published
- 2021
- Full Text
- View/download PDF
44. Effects of different doses of granulocyte colony-stimulating factor mobilization therapy on ischemic cardiomyopathy
- Author
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Rongchong Huang, Yunzeng Zou, Lei Ge, Yiqi Zhang, Kang Yao, Zheyong Huang, Haichen Lv, Hao Lu, Huaiyu Ding, Shuning Zhang, Zhishuai Ye, and Junbo Ge
- Subjects
medicine.medical_specialty ,Cardiac fibrosis ,Swine ,Myocardial Ischemia ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Coronary Angiography ,Article ,Ventricular Function, Left ,Neovascularization ,Contractility ,03 medical and health sciences ,Electrocardiography ,0302 clinical medicine ,Internal medicine ,Granulocyte Colony-Stimulating Factor ,medicine ,Animals ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Ventricular remodeling ,lcsh:Science ,Multidisciplinary ,Ischemic cardiomyopathy ,medicine.diagnostic_test ,Dose-Response Relationship, Drug ,Ventricular Remodeling ,business.industry ,lcsh:R ,Heart ,medicine.disease ,Granulocyte colony-stimulating factor ,Disease Models, Animal ,Cardiology ,lcsh:Q ,medicine.symptom ,business ,Cardiomyopathies - Abstract
G-CSF mobilization might be beneficial to ICM, but the relationship between effect/safety and the dosage of G-CSF remains unclear. In this study, 24 pigs were used to build ICM models and were randomized into four groups. Four weeks later, different dosages of G-CSF were given daily by subcutaneous injection for 5 days. Another 4 weeks later, all the animals were sacrificed. Electrocardiography, coronary arteriography, left ventriculography, transthoracic echocardiography, cardiac MRI, and SPECT, histopathologic analysis, and immunohistochemistry techniques were used to evaluate left ventricular function and myocardial infarct size. Four weeks after G-CSF treatment, pigs in middle-dose G-CSF group exhibited obvious improvements of left ventricular remodeling and function. Moderate G-CSF mobilization ameliorated the regional contractility of ICM, preserved myocardial viability, and reduced myocardial infarct size. More neovascularization and fewer apoptotic myocardial cells were observed in the ischemic region of the heart in middle-dose group. Expression of vWF, VEGF and MCP-1 were up-regulated, and Akt1 was activated in high- and middle-dose groups. Moreover, CRP, TNF-α and S-100 were elevated after high-dose G-CSF mobilization. Middle-dose G-CSF mobilization therapy is an effective and safe treatment for ICM, and probably acts via a mechanism involving promoting neovascularization, inhibiting cardiac fibrosis and anti-apoptosis.
- Published
- 2018
45. Long-term Prognosis of Patients with Acute non-ST-segment Elevation Myocardial Infarction undergoing Different Treatment Strategies
- Author
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Hao Zhu, Ye-Ran Zhu, Yan-E Wang, Da-Peng Shen, Rongchong Huang, Xu-chen Zhou, Jun Liu, Ai-Ming Chen, and Bo Zhang
- Subjects
Male ,Acute coronary syndrome ,medicine.medical_specialty ,Multivariate analysis ,Long-term Outcome ,Myocardial Infarction ,lcsh:Medicine ,Thrombolysis in Myocardial Infarction Risk Score ,Non-ST-segment Elevation Myocardial Infarction ,Internal medicine ,medicine ,ST segment ,Humans ,Myocardial infarction ,Acute Coronary Syndrome ,Aged ,Retrospective Studies ,business.industry ,Mortality rate ,lcsh:R ,Retrospective cohort study ,Invasive Strategy ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Confidence interval ,Surgery ,Relative risk ,Original Article ,Female ,business - Abstract
Background: In cardiology, it is controversial whether different therapy strategies influence prognosis after acute coronary syndrome. We examined and compared the long-term outcomes of invasive and conservative strategies in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and characterized the patients selected for an invasive approach. Methods: A total of 976 patients with acute NSTEMI were collected from December 2006 to October 2012 in the First Affiliated Hospital of Dalian Medical University Hospital. They are divided into conservative strategy (586 patients) and invasive strategy (390 patients) group. Unified follow-up questionnaire was performed by telephone contact (cut-off date was November, 2013). The long-term clinical events were analyzed and related to the different treatment strategies. Results: The median follow-up time was 29 months. Mortality was 28.7% (n = 168) in the conservative group and 2.1% (n = 8) in the invasive management at long-term clinical follow-up. The secondary endpoint (the composite endpoint) was 59.0% (n = 346) in the conservative group and 30.3% (n = 118) in the invasive management. Multivariate analysis showed that patients in the conservative group had higher all-cause mortality rates than those who had the invasive management (adjusted risk ratio [RR] = 7.795; 95% confidence interval [CI]: 3.796-16.006, P < 0.001), and the similar result was also seen in the secondary endpoint (adjusted RR = 2.102; 95% CI: 1.694-2.610, P < 0.001). In the subgroup analysis according to each Thrombolysis in Myocardial Infarction risk score (TRS), log-rank analysis showed lower mortality and secondary endpoint rates in the invasive group with the intermediate and high-risk patients (TRS 3-7). Conclusions: An invasive strategy could improve long-term outcomes for NSTEMI patients, especially for intermediate and high-risk ones (TRS 3-7).
- Published
- 2015
46. The success of opening concurrent chronic total occlusion lesion to improve cardiac function trial in patients with multi-vessel disease (SOS-moral): Study protocol of a prospective multicenter study.
- Author
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Jinfan Tian, Huijuan Zuo, Lijun Zhang, Mingduo Zhang, Dongfeng Zhang, Min Zhang, Yuan Zhou, Yi He, Hongzhi Mi, Xueyao Yang, Rongchong Huang, Xiantao Song, Tian, Jinfan, Zuo, Huijuan, Zhang, Lijun, Zhang, Mingduo, Zhang, Dongfeng, Zhang, Min, Zhou, Yuan, and He, Yi
- Published
- 2020
- Full Text
- View/download PDF
47. Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review.
- Author
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Jinfan Tian, Popal, Mohammad Sharif, RongChong Huang, Min Zhang, Xin Zhao, Mingduo Zhang, and Xiantao Song
- Subjects
CAVEOLINS ,HEART diseases ,VASCULAR diseases - Abstract
Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
48. Timing for intracoronary administration of bone marrow mononuclear cells after acute ST-elevation myocardial infarction: a pilot study
- Author
-
Yuhong Niu, Aijun Sun, Junbo Ge, Lei Ge, Yiqi Zhang, Rongchong Huang, Keqiang Wang, Kang Yao, Juying Qian, and Yunzeng Zou
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Myocardial Infarction ,Medicine (miscellaneous) ,Bone Marrow Cells ,Pilot Projects ,Coronary Angiography ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Ventricular Function, Left ,Young Adult ,Percutaneous Coronary Intervention ,Troponin T ,Internal medicine ,medicine ,Creatine Kinase, MB Form ,Humans ,Transplantation, Homologous ,Myocardial infarction ,cardiovascular diseases ,Cardiac catheterization ,Aged ,Bone Marrow Transplantation ,Tomography, Emission-Computed, Single-Photon ,Ejection fraction ,biology ,business.industry ,Research ,C-reactive protein ,Hemodynamics ,Percutaneous coronary intervention ,Cell Biology ,Middle Aged ,medicine.disease ,Transplantation ,C-Reactive Protein ,Treatment Outcome ,Echocardiography ,Conventional PCI ,biology.protein ,Cardiology ,Molecular Medicine ,Female ,business - Abstract
Most studies on intracoronary bone marrow mononuclear cell transplantation for acute myocardial infarction involve treatment 3–7 days after primary percutaneous coronary intervention (PCI); however, the optimal timing is unknown. The present study assessed the therapeutic effect at different times after ST-elevation myocardial infarction. The present trial was not blinded. A total of 104 patients with a first ST-elevation myocardial infarction and a left ventricular ejection fraction below 50 %, who had PCI of the infarct-related artery, were randomly assigned to receive intracoronary infusion of bone marrow mononuclear cells within 24 hours (group A, n = 27), 3 to 7 days after PCI (group B, n = 26), or 7 to 30 days after PCI (group C, n = 26), or to the control group (n = 25), which received saline infusion performed immediately after emergency PCI. All patients in groups A, B and C received an injection of 15 ml cell suspension containing approximately 4.9 × 108 bone marrow mononuclear cells into the infarct-related artery after successful PCI. Compared to control and group C patients, group A and B patients had a significantly higher absolute increase in left ventricular ejection fraction from baseline to 12 months (change: 3.4 ± 5.7 % in control, 7.9 ± 4.9 % in group A, 6.9 ± 3.9 % in group B, 4.7 ± 3.7 % in group C), a greater decrease in left ventricular end-systolic volumes (change: −6.4 ± 15.9 ml in control, −20.5 ± 13.3 ml in group A, −19.6 ± 11.1 ml in group B, −9.4 ± 16.3 ml in group C), and significantly greater myocardial perfusion (change from baseline: −4.7 ± 5.7 % in control, −7.8 ± 4.5 % in group A, −7.5 ± 2.9 % in group B, −5.0 ± 4.0 % in group C). Group A and B patients had similar beneficial effects on cardiac function (p = 0.163) and left ventricular geometry (left ventricular end-distolic volume: p = 0.685; left ventricular end-systolic volume: p = 0.622) assessed by echocardiography, whereas group C showed similar results to those of the control group. Group B showed more expensive care (p < 0.001) and longer hospital stays during the first month after emergency PCI (p < 0.001) than group A, with a similar improvement after repeat cardiac catheterization following emergency PCI. Cell therapy in acute myocardial infarction patients that is given within 24 hours is similar to 3–7 days after the primary PCI. NCT02425358 , registered 30 April 2015
- Published
- 2015
49. The success of opening single chronic total occlusion lesions to improve myocardialviabilitytrial (SOS-COMEDY): Study protocol of a prospective multicenter study.
- Author
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Rongchong Huang, Xiantao Song, Haishan Zhang, Wen Tian, Zheng Huang, Xingwei Zhang, Junqing Yang, Dongfeng Zhang, Jian Wu, Lei Zhong, Henry H. Ting, Huang, Rongchong, Song, Xiantao, Zhang, Haishan, Tian, Wen, Huang, Zheng, Zhang, Xingwei, Yang, Junqing, Zhang, Dongfeng, and Wu, Jian
- Published
- 2018
- Full Text
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50. Subcutaneous injection of dendritic cells aggravates atherosclerosis in ApoE‑knockout mice by activation of TLR4.
- Author
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ZHISHUAI YE, MINGYU JIN, RONGCHONG HUANG, SHUJING WANG, JIANING ZHANG, and XIANTAO SONG
- Subjects
DENDRITIC cells ,ATHEROSCLEROSIS treatment ,TOLL-like receptors ,ANTIGEN presenting cells ,MAJOR histocompatibility complex ,FLUORESCEIN ,THERAPEUTICS - Abstract
Dendritic cells (DCs) are specialized antigen‑presenting cells which are important in immune diseases, in particular atherosclerosis, a chronic inflammatory disease, however their role in atherosclerosis‑associated immunity is unclear. To evaluate the role of DCs in atherosclerosis, exogenous bone marrow‑derived DCs were transferred into ApoE
‑/‑ mice in the present study. The extent of disease was measured in the aorta and was compared with mice treated with phosphate‑buffered saline (PBS) or left untreated and fed a western diet. Mice receiving exogenous DCs demonstrated significantly larger atherosclerotic lesions compared with the mice treated with PBS, with increasing numbers of mature DCs in circulation and enhanced DC infiltration into plaque lesions, in addition to activation of circulating inflammatory components and atherosclerotic lesions. Furthermore, it was demonstrated that exogenous DCs upregulated the expression of Toll‑like receptor 4 (TLR4) on DCs, which may be an important mechanism to activate DCs and aggravate atherosclerosis. Therefore the present study concluded that exogenous DCs may induce maturation of endogenous DCs via upregulation of TLR4, further increasing the inflammatory response and accelerating atherosclerosis. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
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