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1. Detection of azole resistance in Aspergillus fumigatus complex isolates using MALDI-TOF mass spectrometry

Author

Sánchez-Yebra, Waldo, Sánchez-Gómez, Juan, Lozano, Inmaculada, Marfil, Eduardo, Muñoz de la Rosa, Montserrat, García, Rocío Tejero, Cobo, Fernando, Castro, Carmen, López, Concepción, Rezusta, Antonio, Peláez, Teresa, Castelló-Abietar, Cristian, Costales, Isabel, Serra, Julia Lozano, Jiménez, Rosa, Echeverría, Cristina Labayru, Pérez, Cristina Losa, Megías-Lobón, Gregoria, Lorenzo, Belén, Sánchez-Reus, Ferrán, Ayats, Josefina, Martín, María Teresa, Vidal, Inmaculada, Sánchez-Hellín, Victoria, Ibáñez, Elisa, Pemán, Javier, Fajardo, Miguel, Pazos, Carmen, Rodríguez-Mayo, María, Pérez-Ayala, Ana, Gómez, Elia, Guinea, Jesús, Escribano, Pilar, Serrano, Julia, Reigadas, Elena, Rodríguez, Belén, Zvezdanova, Estreya, Díaz-García, Judith, Gómez-Núñez, Ana, Leiva, José González, Machado, Marina, Muñoz, Patricia, Sánchez-Romero, Isabel, García-Rodríguez, Julio, Luis del Pozo, José, Vallejo, Manuel Rubio, Ruiz de Alegría-Puig, Carlos, López-Soria, Leyre, Marimón, José María, Vicente, Diego, Fernández-Torres, Marina, Hernáez-Crespo, Silvia, Zvezdanova, Margarita Estreya, Arroyo, Manuel J., Méndez, Gema, Candela, Ana, Mancera, Luis, Rodríguez, Julio García, and Rodríguez-Sánchez, Belén

Published
2022
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2. Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Author

Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, Díaz Menéndez, Marta, de la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, Pérez Valero, Ignacio, de Miguel Buckley, Rosa, Cadiñaños Loidi, Julen, Diaz Pollan, Beatriz, Martín Carbonero, Luz, Ramos Ramos, Juan Carlos, Loeches Yagüe, Belén, Montejano Sánchez, Rocío, González García, Juan, García Rodríguez, Julio, Berenguer, Juan, Ramírez, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Pinilla, Blanca, López, Juan Carlos, Such Diaz, Ana, Álvaro Alonso, Elena, Torres Macho, Juan, Cuevas Tascon, Guillermo, Jiménez González de Buitrago, Eva, Brañas Baztán, Fátima, Valencia de la Rosa, Jorge, Pérez Butragueño, Mario, Fernández Jiménez, Inés, Muñiz Nicolás, Gemma, Sepúlveda Berrocal, Antonia, Gato Díez, Alberto, Toledano Sierra, María Pilar, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Fernández Romero, Isidoro, Peláez Ballesta, Cristina, Guirado Torrecillas, María Isabel, Goikoetxea Agirre, Josune, Bereciartua Bastarrica, Elena, Guio Carrión, Laura, Rodríguez Álvarez, Regino, Ibarrola Hierro, Marta, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Román Soto, Sergio, Kallouchi, Mohamed, Domínguez Vicent, Juan Ramón, Silvariño Fernández, Rafae, Ugalde Espiñeira, Jon, Sanjuan López, Ainhoa, García Martínez, Silvia, Temprano Gogenola, Mikel, Asensi, Víctor, Suárez, Silvia, Suárez, Lucia, Yllera, Carmen, Rivas-Carmenado, María, Romero-Palacios, Alberto, Ruiz Aragón, Jesús, Jiménez Aguilar, Patricia, Fernández Ávila, Ma Luisa, Castilla Ortiz, Rosario, Alende Castro, Vanesa, Pérez García, Cristina, Fernández Morales, Marta, Valle Feijoo Begoña Rodríguez Ferreira, María Lorena María, Gómez-Junyent, Joan, Villar-García, Judit, López-Montesinos, Inmaculada, Arrieta-Aldea, Itziar, Rial-Villavecchia, Abora, García Vázquez, Elisa, Roura Piloto, Aychel Elena, Moral Escudero, Encarnación, Hernández Torres, Alicia, Albendín Iglesias, Helena, Vinuesa García, David, Martínez Montes, Clara, De la Hera Fernández, Francisco Javier, Anguita Santos, Francisco, Ruiz Sancho, Andrés, Díaz de Brito Fernández, Vicens, Sanmarti Vilamala, Montserrat, España Cueto, Sergio, Molina Morant, Daniel, González-Cuevas, Araceli, Chara Cervantes, Joel Elías, Policarpo Torres, Guillem, Ortega Montoliu, Meritxell, Angerri Nadal, Mònica, De Genover Gil, Ariadna, Patera, Eleni, Godoy Lorenzo, Rita, Zioga, Evangelia Anna María, Isern Fernández, Virginia, Sabbagh Fajardo, Carlos Enrique, Ferrer Ribera, Ana, Bea Serrano, Carlos, Oltra Sempere, Rosa, Vela Bernal, Sara, Albiol Viñals, Paloma, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, Fiorante, Silvana, Pérez Pinto, Sergio, de la Vega, Alexandra, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Giménez, Teresa, Calvo, Jorge, Meije Castillo, Yolanda, Duarte Borges, Alejandra, Pareja Coca, Júlia, Clemente Presas, Mercedes, Sanz Salvador, Xavier, Pérez Rodríguez, Ma Teresa, Sousa, Adrián, Pérez González, Alexandre, Longueira, Rebeca, Araujo, Alejandro, Alonso Martínez, Blanca, García Escudero, Laura, Lidia Kamel Rey, Sara, Roa Alonso, David, Avilés Parra, Juan Pablo, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Raich Montiu, Laia, Souto Higueras, Jessica, Gálvez Bobadilla, Manuel Alejandro, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Velasco Fuentes, Sara, García Pereña, Laura, Lluna Carrascosa, Alfonso, Gilaberte Reyzábal, Sergio, Liébana Gómez, Mónica, Salillas Hernando, Juan, Serrano Martínez, Alberto, Torralba González de Suso, Miguel, Martínez Martín, Patricia, Rábago Lorite, Isabel, González-Ruano Pérez, Patricia, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Martín Plata, Andrea, Santana Báez, Sergio Manuel, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Robaina Bordón, José María, Vílchez Rueda, Helem Haydeé, Riera Jaume, Melchor, Mut Ramon, Gemma, Gavalda Manso, Meritxell, Planas Bibiloni, Lluis, Castelo Corral, Laura, Ramos Merino, Lucía, Sánchez Vidal, Efrén, Rodríguez Mayo, María, Míguez Rey, Enrique, García de Lomas Guerrero, José M., De la Torre Lima, Javier, Correa Ruiz, Ana, Fernández Sánchez, Fernando, Jiménez-García, Nicolás, Sierra-Monzón, José Luis, Gracia-Tello, Borja, Hernández-Bonaga, María, Pellejero, Galadriel, Asín-Corrochano, Marta, Boix Palop, Lucia, Calbo, Esther, Badía, Cristina, Dietl, Beatriz, Lucía, Gómez, Domínguez-Castellano, Ángel, Ríos-Villegas, María José, del Toro, María D., Palacios Baena, Zaira R., Salamanca-Rivera, Elena, Marín, Elena, Almadana, Virginia, Pérez-Galera, Salvador, González-Iglesias, Luisa, Abelenda-Alonso, Gabriela, Álvarez-Pouso, Claudia, Escrihuela, Francesc, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Salvert Lletí, Miguel, Gil Sánchez, Ricardo, Jiménez Escrig, Marta, Parra Gómez, Laura, Tasias Pitarch, Mariona, Navarro Vilasaró, Marta, Machado Sicilia, María Luisa, Gomila Grange, Aina, Calzado Isbert, Sonia, Carrasco Antón, Nerea, Petkova-Saiz, Elizabet, Cabello Úbeda, Alfonso, Górgolas Hernández-Mora, Miguel, Sánchez-Pernaute, Olga, Dueñas Gutiérrez, Carlos, Martin Guerra, Javier, Castrodeza Sanz, José Javier, Fernández Espinilla, Virginia, Rodríguez Fernández, Laura, González-Moreno, Juan, Villoslada Gelabert, Aroa, Ribot Sanso, María Antonia, Fernández-Baca, María Victoria, Hernández Milian, Almudena, Morán Rodríguez, Miguel Ángel, Ortiz de Zárate Ibarra, Zuriñe, Portu Zapirain, José Joaquin, Saez de Adana Arroniz, Ester, Gainzarain Arana, Juan Carlos, Meca Birlanga, Olga, del Amor Espín, Ma Jesús, Viqueira González, Montserrat, García García, Josefina, Martínez Madrid, Onofre, Bernal Morell, Enrique, Alcaraz, Antonia, Muñoz, Ángeles, Pina, Ignacio, de la Rosa, Vicente, Caínzos Romero, Tamara, Sánchez Trigo, Sabela, Mariño Callejo, Ana Isabel, Álvarez Díaz, Hortensia, Valcarce Pardeiro, Nieves, Sánchez Serrano, Adriana, Piñar Cabezos, Diana, García Villalba, Eva Pilar, Aguayo Jiménez, Carmen, Ruíz Campuzano, María, Naranjo Velasco, Virginia, Santos Peña, Marta, Mora Delgado, Juan, Sevilla Moreno, Israel, Lojo Cruz, Cristina, Kortajarena Urkola, Xabier, Iribarren Loyarte, José Antonio, Bustinduy Odriozola, María Jesús, Ibarguren Pinilla, Maialen, Álvarez Rodríguez, Ignacio, Martínez Marcos, Francisco Javier, Rodríguez Gómez, Francisco Javier, Asschert Agüero, Isabel, Muñoz Beamud, Francisco, Ruiz Reina, Antonio José, Llenas-García, Jara, González-Cuello, Inmaculada, Hellín-Valiente, Elena, Martínez Birlanga, Esther, Tafalla Torres, José Manuel, Calderón Parra, Jorge, Escudero López, Gabriela, Gutiérrez Martín, Isabel, Andrés Eisenhofer, Ane, García Prieto, Sonia, Álvarez Franco, Raquel, Roger Zapata, Daniel, Martínez Cifre, Blanca, Aranda Rife, Elena, Martín Rubio, Irene, Barbosa Ventura, André, Garrido, Javier, Gonzalo, Concepción, Piñero, Iván, de la Cruz Felipe, Nieves, Talavera García, Eva, Lamata Subero, Marta, Mendoza Roy, Paula, García de Carlos, María Soledad, Lajusticia Aisa, Justo, Arteche Eguizabal, Lorea, Urrutia Losada, Ainhoa, Domingo Echaburu, Saioa, Cuadros Tito, Pedro Ángel, Orbe Narváez, Gurutz, Liébana Martos, Ma del Carmen, Roldán Fontana, Carolina, Herrero Rodríguez, Carmen, Duro Ruiz, Gaspar, Pérez Parra, Santiago, Mera Fidalgo, Arantzazu, Hortos Alsina, Miquel, Alberich Conesa, Ana, Bladé Vidal, Lourdes, Merchante Gutiérrez, Nicolás, León Jiménez, Eva, Espíndola Gómez, Reinaldo, Erostarbe Gallardo, María, Martínez Pérez-Crespo, Pedro, Cisneros, José Miguel, Aguilar-Guisado, Manuela, Aldabó, Teresa, Bueno, Claudio, Cordero-Matía, Elisa, Escoresca, Ana, Infante, Carmen, Guillermo, Martín, Salto, Sonsoles, Gioia, Francesca, Vizcarra, Pilar, Fortún Abete, Jesús, Martín Dávila, Pilar, Moreno Guillén, Santiago, Oteo Revuelta, José A., García-García, Concepción, Santibañez Sáenz, Paula, Cervera Acedo, Cristina, Azcona Gutiérrez, José M., Reguera Iglesias, José María, Plata Ciezar, Antonio, Valiente de Santis, Lucia, Sobrino Diaz, Beatriz, Ruiz Mesa, Juan Diego, Rodríguez-Baño, Jesús, Pachón, Jerónimo, Carratalà, Jordi, Ryan, Pablo, Jarrín, Inmaculada, Yllescas, María, and Arribas, José Ramón

Published
2021
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3. Role of age and comorbidities in mortality of patients with infective endocarditis

Author

Armiñanzas, Carlos, Fariñas-Alvarez, Concepción, Zarauza, Jesús, Muñoz, Patricia, González Ramallo, Víctor, Martínez Sellés, Manuel, Miró Meda, José Mª., Pericás, Juan Manuel, Goenaga, Miguel Ángel, Ojeda Burgos, Guillermo, Rodríguez Álvarez, Regino, Castelo Corral, Laura, Gálvez-Acebal, Juan, Martínez Marcos, Francisco Javier, Fariñas, Maria Carmen, Fernández Sánchez, Fernando, Noureddine, Mariam, Rosas, Gabriel, de la Torre Lima, Javier, Aramendi, José, Bereciartua, Elena, Blanco, María José, Blanco, Roberto, Boado, María Victoria, Campaña Lázaro, Marta, Crespo, Alejandro, Goikoetxea, Josune, Iruretagoyena, José Ramón, Irurzun Zuazabal, Josu, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, García López, Mª. Victoria, Georgieva, Radka Ivanova, Ojeda, Guillermo, Rodríguez Bailón, Isabel, Ruiz Morales, Josefa, Cuende, Ana María, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Idígoras, Pedro, Iribarren, José Antonio, Izaguirre Yarza, Alberto, Kortajarena Urkola, Xabier, Reviejo, Carlos, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Miguez Rey, Enrique, Rodríguez Mayo, María, Sánchez, Efrén, Sousa Regueiro, Dolores, Martínez, Francisco Javier, Alonso, Mª. del Mar, Castro, Beatriz, García Rosado, Dácil, Durán, Mª. del Carmen, Miguel Gómez, Mª. Antonia, Lacalzada, Juan, Nassar, Ibrahim, Plata Ciezar, Antonio, Reguera Iglesias, José Mª., Asensi Álvarez, Víctor, Costas, Carlos, de la Hera, Jesús, Fernández Suárez, Jonnathan, Iglesias Fraile, Lisardo, León Arguero, Víctor, López Menéndez, José, Mencia Bajo, Pilar, Morales, Carlos, Moreno Torrico, Alfonso, Palomo, Carmen, Paya Martínez, Begoña, Rodríguez Esteban, Ángeles, Rodríguez García, Raquel, Telenti Asensio, Mauricio, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Llopis Pérez, Jaume, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Bermejo, Javier, Bouza, Emilio, Celemín, Daniel, Cuerpo Caballero, Gregorio, Delgado Montero, Antonia, Fernández Cruz, Ana, García Mansilla, Ana, García Leoni, Mª. Eugenia, Kestler Hernández, Martha, Hualde, Amaia Mari, Marín, Mercedes, Martínez-Sellés, Manuel, Menárguez, Mª. Cruz, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Vázquez, Pilar, Verde Moreno, Eduardo, Antorrena, Isabel, Loeches, Belén, Martín Quirós, Alejandro, Moreno, Mar, Ramírez, Ulises, Rial Bastón, Verónica, Romero, María, Saldaña, Araceli, Agüero Balbín, Jesús, Amado, Cristina, Armiñanzas Castillo, Carlos, Arnaiz García, Ana, Cobo Belaustegui, Manuel, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Gómez Izquierdo, Rubén, García, Iván, González-Rico, Claudia, Gutiérrez-Cuadra, Manuel, Gutiérrez Díez, José, Pajarón, Marcos, Parra, José Antonio, Sarralde, Aurelio, Teira, Ramón, Domínguez, Fernando, García Pavía, Pablo, González, Jesús, Orden, Beatriz, Ramos, Antonio, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Ruiz, Soledad, Hidalgo Tenorio, Carmen, Almendro Delia, Manuel, Araji, Omar, Barquero, José Miguel, Calvo Jambrina, Román, de Cueto, Marina, Gálvez Acebal, Juan, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, García, Emilio, Haro, Juan Luis, Lepe, José Antonio, López, Francisco, Luque, Rafael, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, García-Álvarez, Lara, Oteo, José Antonio, Sanz, Mercedes, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Canut Blasco, Andrés, Cordo Mollar, José, Gainzarain Arana, Juan Carlos, García Uriarte, Oscar, Martín López, Alejandro, Ortiz de Zárate, Zuriñe, Urturi Matos, José Antonio, García Domínguez, Gloria, Sánchez-Porto, Antonio, Arribas Leal, José Mª., García Vázquez, Elisa, Hernández Torres, Alicia, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Moreno Rodríguez, Anai, Tarabini-Castellani, Paola, Heredero Gálvez, Eva, Maicas Bellido, Carolina, Largo Pau, José, Sepúlveda, Mª. Antonia, Toledano Sierra, Pilar, Iqbal-Mirza, Sadaf Zafar, Cascales Alcolea, Eva, Egea Serrano, Pilar, Hernández Roca, José Joaquín, Keituqwa Yañez, Ivan, Peláez Ballesta, Ana, Soriano, Víctor, Moreno Escobar, Eduardo, Peña Monje, Alejandro, Sánchez Cabrera, Valme, Vinuesa García, David, Arrizabalaga Asenjo, María, Cifuentes Luna, Carmen, Núñez Morcillo, Juana, Pérez Seco, Mª. Cruz, Villoslada Gelabert, Aroa, Aured Guallar, Carmen, Fernández Abad, Nuria, García Mangas, Pilar, Matamala Adell, Marta, Palacián Ruiz, Mª. Pilar, Porres, Juan Carlos, Alcaraz Vidal, Begoña, Cobos Trigueros, Nazaret, Del Amor Espín, María Jesús, Giner Caro, José Antonio, Jiménez Sánchez, Roberto, Jimeno Almazán, Amaya, Ortín Freire, Alejandro, Viqueira González, Monserrat, Pericás Ramis, Pere, Ribas Blanco, Mª. Ángels, Ruiz de Gopegui Bordes, Enrique, Vidal Bonet, Laura, Bellón Munera, Mª. Carmen, Escribano Garaizabal, Elena, Tercero Martínez, Antonia, and Segura Luque, Juan Carlos

Published
2019
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4. Azole resistance survey on clinical Aspergillus fumigatus isolates in Spain

Author

Sánchez-Yebra, Waldo, Sánchez-Gómez, Juan, Lozano, Inmaculada, Marfil, Eduardo, Muñoz de la Rosa, Montserrat, García, Rocío Tejero, Cobo, Fernando, Castro, Carmen, López, Concepción, Rezusta, Antonio, Peláez, Teresa, Castelló-Abietar, Cristian, Costales, Isabel, Serra, Julia Lozano, Jiménez, Rosa, Echeverría, Cristina Labayru, Pérez, Cristina Losa, Megías-Lobón, Gregoria, Lorenzo, Belén, Sánchez-Reus, Ferrán, Ayats, Josefina, Martín, María Teresa, Vidal, Inmaculada, Sánchez-Hellín, Victoria, Ibáñez, Elisa, Pemán, Javier, Fajardo, Miguel, Pazos, Carmen, Rodríguez-Mayo, María, Pérez-Ayala, Ana, Gómez, Elia, Guinea, Jesús, Escribano, Pilar, Serrano, Julia, Reigadas, Elena, Rodríguez, Belén, Zvezdanova, Estreya, Díaz-García, Judith, Gómez-Núñez, Ana, Leiva, José González, Machado, Marina, Muñoz, Patricia, Sánchez-Romero, Isabel, García-Rodríguez, Julio, Luis del Pozo, José, Vallejo, Manuel Rubio, Ruiz de Alegría-Puig, Carlos, López-Soria, Leyre, Marimón, José María, Vicente, Diego, Fernández-Torres, Marina, Hernáez-Crespo, Silvia, Rodríguez-Sánchez, Belén, Martín-Gómez, María Teresa, Ibáñez-Martínez, Elisa, García-Gómez de la Pedrosa, Elia, Tejero-García, Rocío, Labayru-Echeverría, Cristina, and Alastruey-Izquierdo, Ana

Published
2021
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5. Emerging subcutaneous mycoses by opportunistic filamentous fungi: A retrospective study in Northwest Spain.

Author

Taibo, Ana, Seoane Estévez, Alejandro, Martínez Campayo, Nieves, Rodríguez Mayo, María, Arévalo Bermúdez, María del Pilar, and Fonseca, Eduardo

Subjects
FILAMENTOUS fungi, MYCOSES, EMERGING infectious diseases, FUSARIUM solani, SKIN infections
Abstract

Background: Subcutaneous mycoses caused by opportunistic filamentous fungi are emerging infections in developed countries due to the longer survival of immunocompromised patients. The evidence published in relation to subcutaneous mycoses is fundamentally based on case reports and small case series. Methods: We performed an observational retrospective study of subcutaneous mycoses caused by opportunistic filamentous fungi diagnosed at our institution between 2017 and 2022. This study aims to estimate the incidence rate of subcutaneous mycoses, identify which fungal species are involved, and analyse which clinical variables predispose to infection and if any are associated with mortality. Results: Fifteen patients met the inclusion criteria. The median age was 61 years (range 27–84), and 80% of them were males. Alternaria spp. were the most common fungi. Two other organisms were frequently isolated: Scedosporium apiospermum and Fusarium solani. Among patients infected with F. solani, 66.7% died. The most common clinical presentation was suppurative nodules in the lower limbs and the main risk factors for infection were immunosuppressants, corticosteroids, previous trauma and transplantation, but they were not particularly associated with increased mortality. A statistically significant association with mortality was only found in the case of positive blood culture (p = <.001). Conclusions: Phaeohyphomycosis has a lower risk of dissemination, especially when compared to subcutaneous mycoses caused by hyalohyphomycetes. It is important to convey the severity of these skin infections to the physicians involved in the treatment and follow‐up of susceptible patients to avoid misdiagnosis and delays in the treatment, especially in the case of hyalohyphomycosis. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Mural Endocarditis: The GAMES Registry Series and Review of the Literature

Author

Gutiérrez-Villanueva, Andrea, Muñoz, Patricia, Delgado-Montero, Antonia, Olmedo-Samperio, María, de Alarcón, Arístides, Gutiérrez-Carretero, Encarnación, Zarauza, Jesús, García i Pares, Delia, Goenaga, Miguel Ángel, Ojeda-Burgos, Guillermo, Goikoetxea-Agirre, Ane Josune, Reguera-Iglesias, José Mª, Ramos, Antonio, Fernández-Cruz, Ana, Fernández-Sánchez, Fernando, García de Lomas, José Mª, Rosas, Gabriel, de la Torre Lima, Javier, Bereciartua, Elena, Blanco-Vidal, María José, Blanco, Roberto, Boado, María Victoria, Campaña-Lázaro, Marta, Crespo, Alejandro, Guio-Carrión, Laura, del Álamo Martínez-Lagos, Mikel, Euba-Ugarte, Gorane, Goikoetxea, Ane Josune, Ibarrola-Hierro, Marta, Iruretagoyena, José Ramón, Irurzun-Zuazabal, Josu, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, García-López, Mª Victoria, Georgieva, Radka Ivanova, Ojeda, Guillermo, Rodríguez-Bailón, Isabel, Ruiz-Morales, Josefa, Azkune-Galparsoro, Harkaitz, Berritu-Boronat, Elisa, Bustinduy-Odriozola, Mª Jesús, del Bosque Martín, Cristina, Echeverría, Tomás, Eizaguirre-Yarza, Alberto, Fuentes, Ana, Goyeneche del Río, Muskilda, Granda-Bauza, Ángela, Iribarren, José Antonio, Kortajarena-Urkola, Xabier, Pérez-Moreiras López, José Ignacio, Rengel-Jiménez, Ainhoa, Reviejo, Karlos, Sáez-Berbejillo, Alberto, Sánchez-Haza, Elou, Sebastián-Alda, Rosa, Solla-Ruiz, Itziar, Unamuno-Ugartemendia, Irati, Anza, Diego Vicente, Villanueva-Benito, Iñaki, Zabalo-Arrieta, Mar, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Miguez-Rey, Enrique, Rodríguez-Mayo, María, Sánchez, Efrén, Sousa-Regueiro, Dolores, Martínez, Francisco Javier, del Mar Alonso, null, Castro, Beatriz, Delgado-Melian, Teresa, Fernández-Sarabia, Javier, García-Rosado, Dácil, González-González, Julia, Lacalzada, Juan, Lorenzo de la Peña, Lissete, Pérez-Ramírez, Alina, Prada-Arrondo, Pablo, Rodríguez-Moreno, Fermín, Plata-Ciezar, Antonio, Asensi-Álvarez, Víctor, Costas, Carlos, de la Hera, Jesús, Fernández-Suárez, Jonnathan, Iglesias-Fraile, Lisardo, León-Arguero, Víctor, López-Menéndez, José, Mencia-Bajo, Pilar, Morales, Carlos, Moreno-Torrico, Alfonso, Palomo, Carmen, Paya-Martínez, Begoña, Rodríguez-Esteban, Ángeles, Rodríguez-García, Raquel, Telenti-Asensio, Mauricio, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Llopis-Pérez, Jaume, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Alonso, Juan Carlos, Álvarez-Uría, Ana, Bermejo, Javier, Bouza, Emilio, Cuerpo-Caballero, Gregorio, González-Mansilla, Ana, García-Leoni, Mª Eugenia, Gargallo, Esther, González-Ramallo, Víctor, Kestler-Hernández, Martha, Hualde, Amaia Mari, Machado, Marina, Marín, Mercedes, Martínez-Sellés, Manuel, Olmedo, María, Pedraz, Álvaro, Pinilla, Blanca, Pinto, Ángel, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Segado, Antonio, Toledo, Neera, Valerio, Maricela, Vázquez, Pilar, Verde-Moreno, Eduardo, Antorrena, Isabel, Loeches, Belén, Moreno, Mar, Ramírez, Ulises, Rial-Bastón, Verónica, Romero, María, Rosillo, Sandra, Agüero-Balbín, Jesús, Amado, Cristina, Armiñanzas-Castillo, Carlos, Arnaiz, Ana, Arnaiz de las Revillas, Francisco, Cobo Belaustegui, Manuel, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Fernández-Sampedro, Marta, García, Iván, González-Rico, Claudia, Gutierrez-Fernandez, Laura, Gutiérrez-Cuadra, Manuel, Gutiérrez-Díez, José, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Calderón-Parra, Jorge, Cobo, Marta, Domínguez, Fernando, García-Pavía, Pablo, Ramos-Martínez, Antonio, Sánchez-Romero, Isabel, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Rodríguez-Roda Stuart, Jorge, Ruiz, Soledad, Hidalgo-Tenorio, Carmen, Almendro-Delia, Manuel, Araji, Omar, Barquero, José Miguel, Calvo-Jambrina, Román, de Cueto, Marina, Gálvez-Acebal, Juan, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, Lepe, José Antonio, López-Haldón, José, Luque-Márquez, Rafael, Marín, Guillermo, Ortiz-Carrellán, Antonio, Sánchez-Domínguez, Eladio, Alonso, Luis Javier, Azcárate, Pedro, Azcona-Gutiérrez, José Manuel, Blanco, José Ramón, Cabrera-Villegas, Antonio, García-Álvarez, Lara, García-García, Concepción, Oteo, José Antonio, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, null, Fernández, null, Martínez, Amparo, Prieto, null, Regueiro, Benito, Tijeira, null, Vega, Marino, Canut-Blasco, Andrés, Mollar, José Cordo, Gainzarain-Arana, Juan Carlos, García-Uriarte, Oscar, Martín-López, Alejandro, Ortiz de Zárate, Zuriñe, Urturi-Matos, José Antonio, Sánchez-Porto, Antonio, Úbeda-Iglesias, Alejandro, Arribas-Leal, José Mª, García-Vázquez, Elisa, Hernández-Torres, Alicia, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Moreno-Rodríguez, Anai, Tarabini-Castellani, Paola, Heredero-Gálvez, Eva, Maicas-Bellido, Carolina, Largo-Pau, José, Sepúlveda, Mª Antonia, Toledano-Sierra, Pilar, Iqbal-Mirza, Sadaf Zafar, Cascales-Alcolea, Eva, Keituqwa-Yañez, Ivan, Navarro-Martínez, Julián, Peláez-Ballesta, Ana, Moreno-Escobar, Eduardo, Peña-Monje, Alejandro, Sánchez-Cabrera, Valme, Vinuesa-García, David, Arrizabalaga-Asenjo, María, Cifuentes-Luna, Carmen, Núñez-Morcillo, Juana, Pérez-Seco, Mª Cruz, Villoslada-Gelabert, Aroa, Aured-Guallar, Carmen, Fernández-Abad, Nuria, García-Mangas, Pilar, Matamala-Adell, Marta, Palacián-Ruiz, Mª Pilar, Porres, Juan Carlos, Alcaraz-Vidal, Begoña, Cobos-Trigueros, Nazaret, Del Amor Espín, María Jesús, Giner-Caro, José Antonio, Jiménez-Sánchez, Roberto, Jimeno-Almazán, Amaya, Ortín-Freire, Alejandro, Viqueira-González, Monserrat, Pericás-Ramis, Pere, Ribas-Blanco, Mª Ángels, Ruiz de Gopegui Bordes, Enrique, Vidal-Bonet, Laura, Bellón-Munera, Mª Carmen, Escribano-Garaizabal, Elena, Tercero-Martínez, Antonia, Segura-Luque, Juan Carlos, Badía, Cristina, Boix-Palop, Lucía, Xercavins, Mariona, Ibars, Sónia, Bosch, Xerach, Gómez-Nebreda, Eloy, Horcajada-Herrera, Ibalia, Menduiña-Gallego, Irene, Pulido, Imanol, Marrero-Santiago, Héctor, de Miguel Martínez, Isabel, Pisos-Álamo, Elena, Aguilar-Blanco, Eva Mª, Catalán-González, Mercedes, Corres-Peiretti, María Angélica, Eixerés-Esteve, Andrea, Domínguez-Pérez, Laura, de Cossío Tejido, Santiago, Galván-Román, Francisco, García-Robles, José Antonio, López-Medrano, Francisco, López-Gude, Mª Jesús, Orellana-Miguel, Mª Ángeles, Pilkington, Patrick, Revilla-Ostalaza, Yolanda, Morales, Juan Ruiz, Ruiz-Solís, Sebastián, Collado, Ana Sabín, Sánchez-Fernández, Marcos, Rallo, Javier Solera, Martín, Jorge Solís, Cuervo, Guillermo, Escrihuela-Vidal, Francesc, Carratalà, Jordi, Grau, Inmaculada, Grillo, Sara, Ardanuy, Carmen, Berbel, Dámaris, Sánchez-Salado, José Carlos, Alegre, Oriol, Ruiz-Majoral, Alejandro, Sbraga, Fabrizio, Blasco, Arnau, Sánchez, Laura Gracia, Sánchez-Rodríguez, Iván, Álvarez, Beatriz, Cabello-Úbeda, Alfonso, Fernández-Roblas, Ricardo, Navas-Lobato, Miguel Ángel, Pello, Ana María, de la Peña Triguero, Mireia, Figueroa-Cerón, Ruth Esther, Ruiz-Gómez, Lara, Ble, Mireia, Horcajada-Gallego, Juan Pablo, Ginel, Antonio José, López, Inmaculada, Mas, Alexandra, Mestres, Antoni, Molina, Lluís, Serrat, Ramón, Ribas, Núria, Sánchez, Francisca, Silverio, Ana, Suárez, Marina, Sorlí, Luisa, Recasens, Lluís, Taurón, Manuel, 0000-0003-1189-1120, and Universidad de Cantabria

Subjects
Microbiology (medical), medicine.medical_specialty, medicine.medical_treatment, Charlson index, Infections, Hospital patients, Mural, Internal medicine, medicine, Endocarditis, Malalts hospitalitzats, business.industry, Brief Report, medicine.disease, Infeccions, Transplantation, Catheter, Non-valvular endocarditis, Infectious Diseases, Infective endocarditis, Etiology, Hemodialysis, Complication, business, human activities
Abstract

Spanish Collaboration on Endocarditis—Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)., [Introduction] Mural infective endocarditis (MIE) is a rare type of endovascular infection. We present a comprehensive series of patients with mural endocarditis., [Methods] Patients with infectious endocarditis (IE) from 35 Spanish hospitals were prospectively included in the GAMES registry between 2008 and 2017. MIEs were compared to non-MIEs. We also performed a literature search for cases of MIE published between 1979 and 2019 and compared them to the GAMEs series., [Results] Twenty-seven MIEs out of 3676 IEs were included. When compared to valvular IE (VIE) or device-associated IE (DIE), patients with MIE were younger (median age 59 years, p, [Conclusion] MIE is a rare entity. It is often a complication of catheter use, particularly in immunocompromised and hemodialysis patients. Fungal etiology is common. Mortality is similar to other IEs.

Published
2021

7. Microbiology in burns patients with blood stream infections: trends over time and during the course of hospitalization.

Author

Sousa, Dolores, Ceniceros, Alejandra, Galeiras, Rita, Pértega-Díaz, Sonia, Gutiérrez-Urbón, José-María, Rodríguez-Mayo, María, López-Suso, Eugenia, Mourelo-Fariña, Mónica, and Llinares, Pedro

Subjects
ANTIBIOTIC synthesis, GRAM-positive bacteria, PATHOGENIC microorganisms, PATIENTS, BURNS & scalds, HOSPITAL care
Abstract

Background: Bloodstream infections (BSI) are a major cause of mortality in burns patients. Knowledge of the microbiology is crucial to direct empirical therapy. We sought to determine the causative microorganisms and antibiotic resistance in burns patients with BSI. Methods: All consecutive BSI episodes in a tertiary hospital burns unit from 2000 to 2014 were included. The following three subperiods were compared: 2000-2004, 2005-2009 and 2010-2014. Changes in BSI occurring during early and late hospitalization periods were evaluated. Results: A total of 103 BSI episodes were included. The cumulative incidence was 2.4 episodes/1000 patient days. A positive trend in the frequency of Gram-negative BSI, especially in the upsurge of Pseudomonas aeruginosa and Klebsiella spp. BSI after 2004, was observed. The most common causative pathogens in early BSI were Gram-positive microorganisms. P. aeruginosa and Klebsiella spp. became the predominant aetiology in the fourth week of hospitalization and beyond. There was a progressive increase in imipenem-resistant P. aeruginosa over time (0%, 67%, 75% in 2000-2004, 2005-2009, 2010-2014, respectively) and during the hospital stay (50% vs. 85.7%, in <7 days-BSI vs. >30 days-BSI, respectively). A higher SOFA (Sepsis-related Organ Failure Assessment) score was associated with Gram-negative BSI versus non-Gram-negative BSI (median: 2.5 vs. 0; p = 0.041). Conclusions: There is a changing trend in the types of pathogens causing BSI in burns patients over the 14-year period and during the course of hospitalization. The problematic increase in carbapenem-resistance highlights the need for new antimicrobial stewardship policies and antibiotic prescribing protocols. [ABSTRACT FROM AUTHOR]

Published
2018
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9. Serotypes and genotypes of S. pneumoniae isolates from adult invasive disease in Spain: A 5-year prospective surveillance after pediatric PCV13 licensure. The ODIN study.

Author

Fenoll, Asunción, Ardanuy, Carmen, Liñares, Josefina, Cercenado, Emilia, Marco, Francesc, Fleites, Ana, Rodríguez-Mayo, María, López-Hontangas, Jose-Luis, Palop, Begoña, Aller, Ana-Isabel, Buendía, Buenaventura, Méndez, Cristina, and Cifuentes, Isabel

Subjects
*SEROTYPES, *GENOTYPES, *STREPTOCOCCUS pneumoniae, *EPIDEMIOLOGY, *VACCINES, *IMMUNE response
Abstract

Abstract Serotypes/genotypes causing invasive pneumococcal disease (IPD) in adults are determined by vaccination strategies. The aim of this study was to assess the epidemiology of IPD in adults (≥18 years) after PCV13 introduction for children: serotypes, clonal complexes, antibiotic non-susceptibility and clinical presentations. We performed a prospective, clinical surveillance of hospitalized culture-confirmed IPDs in adults in nine Spanish hospitals (August 2010–June 2015). A total of 1087 culture-confirmed IPD episodes were included, of which 772 (71.0%) had bacteremic pneumonia (401 complicated/371 uncomplicated pneumonia), 122 (11.2%) meningitis, 102 (9.4%) non-focal bacteremia, 34 (3.1%) peritonitis and 57 (5.3%) others. The most common serotypes were: 3 (12.7%), 19A (8.5%), 8 (7.7%), 7F (6.3%), 1 (4.2%), 6C (4.2%), 11A (4.2%), 22F (4.2%) and 14 (4.0%). Vaccine types (PCV13 + 6C) caused 49.8% of IPD episodes, with a significant decrease over the 5-year period, and significant decreases in serotypes 6C and 7F. The most common genotypes were: CC180 (8.4%), CC191 (6.0%), and CC53 (5.0%). Vaccine types caused 53.9% (414/768) pneumonia episodes and 58.9% (235/399) complicated pneumonia, 53.4% IPD in adults <50 years (143/268), and 54.7% IPD in immunocompetent patients (337/616). Overall non-susceptibility was 25.9% to penicillin (1.1% for parenteral criteria), 24.9% to erythromycin and 2.7% to levofloxacin. Conclusions Although the percentage of vaccine-types causing IPDs in adults significantly decreased, it remained high. Associations of vaccine types with pneumonia (with complicated pneumonia for specific serotypes), and immunocompetent patients point to the burden of IPD caused by PCV13 serotypes. [ABSTRACT FROM AUTHOR]

Published
2018
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10. Azole resistance survey on clinical Aspergillus fumigatus isolates in Spain.

Author

Escribano, Pilar, Rodríguez-Sánchez, Belén, Díaz-García, Judith, Martín-Gómez, María Teresa, Ibáñez-Martínez, Elisa, Rodríguez-Mayo, María, Peláez, Teresa, García-Gómez de la Pedrosa, Elia, Tejero-García, Rocío, Marimón, José María, Reigadas, Elena, Rezusta, Antonio, Labayru-Echeverría, Cristina, Pérez-Ayala, Ana, Ayats, Josefina, Cobo, Fernando, Pazos, Carmen, López-Soria, Leyre, Alastruey-Izquierdo, Ana, and Muñoz, Patricia

Subjects
*ASPERGILLUS fumigatus, *AZOLES, *AMPHOTERICIN B, *HOSPITAL patients, *DOMINANCE (Genetics)
Abstract

We aimed to assess the percentage of azole resistance in Aspergillus fumigatus in Spain. Thirty participating Spanish hospitals stored all morphologically identified A. fumigatus sensu lato clinical isolates—regardless their clinical significance—from 15 February to 14 May 2019. Isolates showing azole resistance according to the EUCAST 9.3.2 methodology were molecularly identified and the cyp51A gene was studied in A. fumigatus sensu stricto isolates. Eight hundred and forty-seven isolates from 725 patients were collected in 29 hospitals (A. fumigatus sensu stricto (n = 828) and cryptic species (n = 19)). Isolates were mostly from the lower respiratory tract (94.0%; 797/847). Only cryptic species were amphotericin B resistant. Sixty-three (7.4%) out of the 847 isolates were resistant to ≥1 azole(s). Azole resistance was higher in cryptic species than in A. fumigatus sensu stricto (95%, 18/19 vs. 5.5%, 45/828); isavuconazole was associated to the lowest number of non-wild type isolates. The dominant mechanism of resistance was the presence of TR 34 -L98H substitutions (n = 24 out of 63). Out of the 725 patients, 48 (6.6%) carried either cryptic species (n = 14) or A. fumigatus sensu stricto (n = 34; 4.7%) resistant isolates. Aspergillus fumigatus sensu stricto harbouring either the TR 34 -L98H (n = 19) or TR 46 /Y121F/T289A (n = 1) mutations were detected in patients in hospitals located at 7/24 studied cities. Of the patients, 6.6% carry azole-resistant A. fumigatus sensu lato isolates in Spain. TR 34 -L98H is the dominant cyp51A gene substitutions, although its presence is not widespread. [ABSTRACT FROM AUTHOR]

Published
2021
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11. In vivo emergence of resistance to ceftazidime/avibactam through modification of chromosomal AmpC β-lactamase in Klebsiella aerogenes .

Author

Rodríguez-Pallares S, Blanco-Martín T, Lence E, Aja-Macaya P, Sánchez-Peña L, González-Pinto L, Rodríguez-Mayo M, Fernández-González A, Galán-Sánchez F, Beceiro A, González-Bello C, Bou G, and Arca-Suárez J

Subjects
Humans, Whole Genome Sequencing, Klebsiella Infections drug therapy, Klebsiella Infections microbiology, Drug Resistance, Multiple, Bacterial genetics, Mutation, Ceftazidime pharmacology, Azabicyclo Compounds pharmacology, beta-Lactamases genetics, beta-Lactamases metabolism, Drug Combinations, Bacterial Proteins genetics, Bacterial Proteins metabolism, Anti-Bacterial Agents pharmacology, Microbial Sensitivity Tests, Enterobacter aerogenes drug effects, Enterobacter aerogenes genetics, Enterobacter aerogenes enzymology
Abstract

We describe the in vivo emergence of resistance to ceftazidime/avibactam via modification of AmpC in a clinical Klebsiella aerogenes isolate during therapy with this combination. Paired ceftazidime/avibactam-susceptible/resistant isolates were obtained before and during ceftazidime/avibactam treatment. Whole genome sequencing revealed a differential mutation in AmpC (R148W) in the ceftazidime/avibactam-resistant isolate. Molecular cloning and structural studies confirmed the impact of this substitution, which affects the architecture of the H10 helix, on the evolved resistant phenotype., Competing Interests: G.B. has received funding and study materials from MSD, grants contracts from MSD, Pfizer, ABAC Therapeutics, and Roche, consulting fees and honoraria for lectures and/or presentations from MSD, Shionogi Pfizer, Roche, and Menarini, and support for attending meetings and/or travels from Pfizer. J.A.-S. has received honoraria for lectures, consulting fees, and/or presentations from MSD, Shionogi, Pfizer, and Advanz Pharma.

Published
2024
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