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4 results on '"Robert Małecki"'

1. Optimized procedures for testing plasma metanephrines in patients on hemodialysis

Author

Christina Pamporaki, Aleksander Prejbisz, Robert Małecki, Frank Pistrosch, Mirko Peitzsch, Steffen Bishoff, Petra Mueller, Iris Meyer, Doreen Reimann, Katarzyna Hanus, Andrzej Januszewicz, Stefan R. Bornstein, Simon Parmentier, Carola Kunath, Jacques W. M. Lenders, Graeme Eisenhofer, and Jens Passauer

Subjects
Medicine, Science
Abstract

Abstract Diagnosis of pheochromocytomas and paragangliomas in patients receiving hemodialysis is troublesome. The aim of the study was to establish optimal conditions for blood sampling for mass spectrometric measurements of normetanephrine, metanephrine and 3-methoxytyramine in patients on hemodialysis and specific reference intervals for plasma metanephrines under the most optimal sampling conditions. Blood was sampled before and near the end of dialysis, including different sampling sites in 170 patients on hemodialysis. Plasma normetanephrine concentrations were lower (P

Published
2021
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2. Niemcy – migracja jako impuls do krytyki kultury?

Author

Wiesław Robert Małecki

Subjects
German culture, temporary migration crisis, cultural identity, postmigration society, Ethnology. Social and cultural anthropology, GN301-674, Political science
Abstract

Germany – migration as a culture critic? The common roots of the crisis and criticism indicate that the contemporary „migrant crisis” in Europe can also give a fundamental impulse to the criticism of culture—one so far-reaching that it can lay the foundations for a new cultural identity. The subject of this analysis is Germany as a cultural space in Europe and a unique community. Due to its history and both post- and always pre-national character, it is faced with a great opportunity to create a model of social integration yet unseen on the Old Continent. There is one condition: Germany will need to create a relevant cultural myth. This article presents three possible argumentative paths which show that such a scenario is not unlikely. Niemcy – migracja jako impuls do krytyki kultury? Wspólne korzenie kryzysu i krytyki wskazują, że współczesny „kryzys migracyjny” w Europie może stać się także zasadniczym impulsem do krytyki kultury. Krytyki na tyle daleko idącej, że może ona zrodzić fundamenty nowej kulturowej tożsamości. Przedmiotem analiz są tutaj Niemcy, jako kulturowa przestrzeń w Europie, jako szczególna „wspólnota”, która ze względu na swoją historię i post- a zarazem zawsze już przednarodowy charakter, staje przed ogromną szansą stworzenia niewidzianego na Starym Kontynencie modelu integracji społecznej. Pod warunkiem, że uda się im stworzyć odpowiedni mit kulturowy. W artykule przedstawione zostały trzy możliwe ścieżki argumentacyjne, które wskazują, że taki scenariusz nie jest nieprawdopodobny.

Published
2018
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3. Diabetic kidney disease: Are the reported associations with single-nucleotide polymorphisms disease-specific?

Author

Dorota Brodowska-Kania, Grzegorz Kamiński, Przemysław Dyrla, Stanisław Niemczyk, Wawrzyniec Żmudzki, Maria Franaszczyk, Longin Niemczyk, Rafał Płoski, Marek Saracyn, Bartłomiej Kisiel, and Robert Małecki

Subjects
Disease specific, Single-nucleotide polymorphism, Diabetic kidney, urogenital system, business.industry, Endocrinology, Diabetes and Metabolism, End-stage kidney disease, Disease, Case Control Study, medicine.disease, Bioinformatics, Diabetes mellitus, Chronic kidney disease, Internal Medicine, Medicine, Diabetic kidney disease, business
Abstract

BACKGROUND The genetic backgrounds of diabetic kidney disease (DKD) and end-stage kidney disease (ESKD) have not been fully elucidated. AIM To examine the individual and cumulative effects of single-nucleotide polymorphisms (SNPs) previously associated with DKD on the risk for ESKD of diabetic etiology and to determine if any associations observed were specific for DKD. METHODS Fourteen SNPs were genotyped in hemodialyzed 136 patients with diabetic ESKD (DKD group) and 121 patients with non-diabetic ESKD (NDKD group). Patients were also re-classified on the basis of the primary cause of chronic kidney disease (CKD). The distribution of alleles was compared between diabetic and non-diabetic groups as well as between different sub-phenotypes. The weighted multilocus genetic risk score (GRS) was calculated to estimate the cumulative risk conferred by all SNPs. The GRS distribution was then compared between the DKD and NDKD groups as well as in the groups according to the primary cause of CKD. RESULTS One SNP (rs841853; SLC2A1) showed a nominal association with DKD (P = 0.048; P > 0.05 after Bonferroni correction). The GRS was higher in the DKD group (0.615 ± 0.260) than in the NDKD group (0.590 ± 0.253), but the difference was not significant (P = 0.46). The analysis of associations between GRS and individual factors did not show any significant correlation. However, the GRS was significantly higher in patients with glomerular disease than in those with tubulointerstitial disease (P = 0.014) and in those with a combined group (tubulointerstitial, vascular, and cystic and congenital disease) (P = 0.018). CONCLUSION Our results suggest that selected SNPs that were previously associated with DKD may not be specific for DKD and may confer risk for CKD of different etiology, particularly those affecting renal glomeruli.

Published
2021

4. The standard of urological consultation of patients qualified for renal transplant – a review

Author

Robert Małecki, Artur A. Antoniewicz, Łukasz Zapała, and Arkadiusz Bogucki

Subjects
kidney transplant, medicine.medical_specialty, Review Paper, business.industry, Alternative medicine, General Medicine, medicine.disease, Kidney transplant, urological qualification, kidney failure, Renal transplant, Waiting list, medicine, In patient, Intensive care medicine, business, Kidney transplantation
Abstract

Urological consultation is an important step in the procedure of a patient's preparation before placing him/her on a waiting list for a renal transplant. Urological work-up aims to diagnose, treat, and optimize any preexisting urological disease. In the present paper we present the review of the literature together with the authors' conclusions based on literature and their experience. There is not enough data in current literature and urology manuals on the adequate sequence of the urological management with patients qualified for renal transplant and the literature needs an update. This study presents the crucial steps of the qualification and emphasizes the urge for a more standardized urological approach in patients qualified for a kidney transplantation.

Published
2015

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