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231 results on '"Rincon-Torroella, Jordina"'

7. Impact of Antithrombotic Medications and Reversal Strategies on the Surgical Management and Outcomes of Traumatic Acute Subdural Hematoma

Author

Vattipally, Vikas N., Ran, Kathleen R., Giwa, Ganiat A., Myneni, Saket, Dardick, Joseph M., Rincon-Torroella, Jordina, Ye, Xiaobu, Byrne, James P., Suarez, Jose I., Lin, Shih-Chun, Jackson, Christopher M., Mukherjee, Debraj, Gallia, Gary L., Huang, Judy, Weingart, Jon D., Azad, Tej D., and Bettegowda, Chetan

Published
2024
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9. ASXL1 inactivation and reduced H3K27me3 across central nervous system tumors

Author

Zhang, Kevin Y., Parker, Megan, Weber-Levine, Carly, Kalluri, Anita, Gonzalez-Gomez, Ignacio, Raabe, Eric, Dudley, Jonathan C., Gocke, Christopher, Lin, Ming-Tseh, Zou, Ying, Sherief, Mohamed, Kamson, David O., Holdhoff, Matthias, Mukherjee, Debraj, Croog, Victoria, Schreck, Karisa C., Rincon-Torroella, Jordina, Bettegowda, Chetan, Eberhart, Charles G., Bale, Tejus, and Lucas, Calixto-Hope G.

Published
2024
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18. The Role of γδ T-Lymphocytes in Glioblastoma: Current Trends and Future Directions.

Author

Ahmedna, Taha, Khela, Harmon, Weber-Levine, Carly, Azad, Tej D., Jackson, Christopher M., Gabrielson, Kathleen, Bettegowda, Chetan, and Rincon-Torroella, Jordina

Subjects
GLIOMA treatment, CELLULAR therapy, CELL receptors, GLIOMAS, RISK assessment, T cells, MEDICAL research, IMMUNOTHERAPY, HYPOXEMIA
Abstract

Simple Summary: Glioblastoma is one of the most aggressive brain tumors, with poor survival and early recurrence rates. The development of effective immunotherapy treatments has been limited by the infiltration-resistant and immunosuppressive tumor microenvironments of these tumors. γδ T cells are unconventional T cells that have the potential to overcome these challenges through their unique recognition of molecular targets on glioblastoma cells. Nonetheless, challenges exist in the utilization of these cells, including their isolation, expansion, and potential for protumor activity. In this review, we discuss the biology of γδ T cells and their role in immunotherapy for glioblastoma and propose several research avenues for future studies. Cell-based immunotherapy for glioblastoma (GBM) encounters major challenges due to the infiltration-resistant and immunosuppressive tumor microenvironment (TME). γδ T cells, unconventional T cells expressing the characteristic γδ T cell receptor, have demonstrated promise in overcoming these challenges, suggesting great immunotherapeutic potential. This review presents the role of γδ T cells in GBM and proposes several research avenues for future studies. Using the PubMed, ScienceDirect, and JSTOR databases, we performed a review of the literature studying the biology of γδ T cells and their role in GBM treatment. We identified 15 studies focused on γδ T cells in human GBM. Infiltrative γδ T cells can incite antitumor immune responses in certain TMEs, though rapid tumor progression and TME hypoxia may impact the extent of tumor suppression. In the studies, available findings have shown both the potential for robust antitumor activity and the risk of protumor activity. While γδ T cells have potential as a therapeutic agent against GBM, the technical challenges of extracting, isolating, and expanding γδ T cells, and the activation of antitumoral versus protumoral cascades, remain barriers to their application. Overcoming these limitations may transform γδ T cells into a promising immunotherapy in GBM. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Management and Molecular Characterization of Intraventricular Glioblastoma: A Single-Institution Case Series.

Author

Parker, Megan, Kalluri, Anita, Materi, Joshua, Gujar, Sachin K., Schreck, Karisa, Mukherjee, Debraj, Weingart, Jon, Brem, Henry, Redmond, Kristin J., Lucas, Calixto-Hope G., Bettegowda, Chetan, and Rincon-Torroella, Jordina

Subjects
RIGHT heart atrium, GLIOBLASTOMA multiforme, GENE amplification, TUMOR classification, HYDROCEPHALUS, CEREBROSPINAL fluid shunts, BREAST
Abstract

While the central nervous system (CNS) tumor classification has increasingly incorporated molecular parameters, there is a paucity of literature reporting molecular alterations found in intraventricular glioblastoma (IVGBM), which are rare. We present a case series of nine IVGBMs, including molecular alterations found in standardized next-generation sequencing (NGS). We queried the clinical charts, operative notes, pathology reports, and radiographic images of nine patients with histologically confirmed IVGBM treated at our institution (1995–2021). Routine NGS was performed on resected tumor tissue of two patients. In this retrospective case series of nine patients (22% female, median (range) age: 64.3 (36–85) years), the most common tumor locations were the atrium of the right lateral ventricle (33%) and the septum pellucidum (33%). Five patients had preoperative hydrocephalus, which was managed with intraoperative external ventricular drains in three patients and ventriculoperitoneal shunts in one patient. Hydrocephalus was managed with subtotal resection of a fourth ventricular IVGBM in one patient. The most common surgical approach was transcortical intraventricular (56%). Gross total resection was achieved in two patients, subtotal resection was achieved in six patients, and one patient received a biopsy only. Immunohistochemistry for IDH1 R132H mutant protein was performed in four cases and was negative in all four. Genetic alterations common in glioblastoma, IDH-wildtype, were seen in two cases with available NGS data, including EGFR gene amplification, TERT promoter mutation, PTEN mutation, trisomy of chromosome 7, and monosomy of chromosome 10. Following surgical resection, four patients received adjuvant chemoradiation. Median survival among our cohort was 4.7 months (IQR: 0.9–5.8 months). Management of IVGBM is particularly challenging due to their anatomical location, presentation with obstructive hydrocephalus, and fast growth, necessitating prompt intervention. Additional studies are needed to better understand the genetic landscape of IVGBM compared to parenchymal glioblastoma and may further elucidate the unique pathophysiology of these rare tumors. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid

Author

Douville, Christopher, Curtis, Samuel, Summers, Mahmoud, Azad, Tej D., Rincon-Torroella, Jordina, Wang, Yuxuan, Mattox, Austin, Avigdor, Bracha, Dudley, Jonathan, Materi, Joshua, Raj, Divyaansh, Nair, Sumil, Bhanja, Debarati, Tuohy, Kyle, Dobbyn, Lisa, Popoli, Maria, Ptak, Janine, Nehme, Nadine, Silliman, Natalie, Blair, Cherie, Judge, Kathy, Gallia, Gary L., Groves, Mari, Jackson, Christopher M., Jackson, Eric M., Laterra, John, Lim, Michael, Mukherjee, Debraj, Weingart, Jon, Naidoo, Jarushka, Koschmann, Carl, Smith, Natalya, Schreck, Karisa C., Pardo, Carlos A., Glantz, Michael, Holdhoff, Matthias, Kinzler, Kenneth W., Papadopoulos, Nickolas, Vogelstein, Bert, and Bettegowda, Chetan

Published
2023
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47. Contributors

Author

Abello, Eric H., Abiri, Arash, Adappa, Nithin D., Ahmad, Meleha, Almeida, Joao Paulo, Alrasheed, Abdulaziz S., Arrighi-Allisan, Annie, Barton, Blair M., Bastien, Amanda J., Battaglia, Paolo, Biousse, Valérie, Bleier, Benjamin S., Carrau, Ricardo L., Castelnuovo, Paolo, Chaaban, Mohamad R., Chan, David, Chemas-Velez, Maria Manuela, Chen, Benson S., Chou, Brian W., Cote, David J., Cutsforth-Gregory, Jeremy K., Czaczkes, Camilla, Dalfino, Gianluca, Das, Paramita, Junior de Andrade, Erion, Filho, Leonardo de Macedo, Eloy, Jean Anderson, Evans, James J., Fang, Christina H., Filip, Peter, Francis, Courtney E., Gallia, Gary L., Gardner, Paul A., Gentili, Fred, Georgalas, Christos, Ginat, Daniel T., Gogia, Angad S., Govindaraj, Satish, Grayson, Jessica W., Gudis, David A., Halderman, Ashleigh A., Harvey, Richard J., Hernandez, Stephen, Higgins, Mamie, Horowitz, Peleg Moshe, Illing, Elisa A., Ishii, Masaru, Kamel, Peter, Kang, Keiko M., Karp, Emily, Karsy, Michael J., Kshettry, Varun R., Kshirsagar, Rijul S., Kuan, Edward C., Lamarre, Eric, Levy, Joshua M., Link, Michael, Little, Andrew S., Liu, Ann, Liu, James K., Locatelli, Davide, Sr., Luna, Licia P., Mahomva, Chengetai, McCulley, Timothy J., Medina, Eduardo J., Michael, Alex P., Miglani, Amar, Mihal, David, Moe, Kris S., Nadgir, Rohini, Nicholson, Patrick, Nyquist, Gurston G., Oostra, Amanda, Oswald, Aaron, Palmer, James N., Parsel, Sean M., Patel, Prayag, Petrauskas, Laura, Porto, Edoardo, Pradilla, Gustavo, Prashant, Giyarpuram N., Prevedello, Daniel, Qureshi, Hannan A., Rabinowitz, Mindy R., Radovanovic, Ivan, Ramanathan, Murugappan, Jr., Rao, Shilpa M., Ray, Amrita, Rech, Matheus, Recinos, Pablo F., Barbero, J. Manuel Revuelta, Rincon-Torroella, Jordina, Rosen, Marc R., Roxbury, Christopher R., Ruggieri, Paul, Safi, Chetan, Santarelli, Griffin D., Sarris, Christina E., Schlosser, Rodney J., Schwartz, Theodore H., Shah, Janki, Sindwani, Raj, Snyderman, Carl H., Sommerfeld, Connor, Soriano, Roberto M., Sreenath, Satyan B., Stokken, Janalee, Tabaee, Abtin, Tang, Dennis M., Timmons, Shelly D., Ting, Jonathan, Turri-Zanoni, Mario, Vorster, Sarel J., Vyskocil, Erich, Warren, Zachary, Watley, Duncan C., White, Alexandra J., Williams, Michael A., Woodard, Troy D., Woodworth, Bradford A., Workman, Alan D., Wormald, Peter-John, Wrobel, Bozena B., Zada, Gabriel, Zanation, Adam, Zhao, Jiawei, and Zimmer, David I.

Published
2024
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49. Single-Cell RNA Sequencing of Cerebrospinal Fluid as an Advanced Form of Liquid Biopsy for Neurological Disorders.

Author

Yekula, Anudeep, Tracz, Jovanna, Rincon-Torroella, Jordina, Azad, Tej, and Bettegowda, Chetan

Subjects
RNA sequencing, CEREBROSPINAL fluid, NEUROLOGICAL disorders, CENTRAL nervous system diseases, PATHOLOGY
Abstract

Diagnosis and longitudinal monitoring of neurological diseases are limited by the poor specificity and limited resolution of currently available techniques. Analysis of circulating cells in cerebrospinal fluid (CSF) has emerged as a promising strategy for the diagnosis, molecular characterization, and monitoring of neurological disease. In comparison to bulk sequencing analysis, single-cell sequencing studies can provide novel insights into rare cell populations and uncover heterogeneity in gene expression at a single-cell resolution, which has several implications for understanding disease pathology and treatment. Parallel development of standardized biofluid collection protocols, pre-processing strategies, reliable single-cell isolation strategies, downstream genomic analysis, and robust computational analysis is paramount for comprehensive single-cell sequencing analysis. Here we perform a comprehensive review of studies focusing on single-cell sequencing of cells in the CSF of patients with oncological or non-oncological diseases of the central nervous system. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Impact of international research fellows in neurosurgery: results from a single academic center.

Author

Wuyang Yang, Rincon-Torroella, Jordina, Feghali, James, Khalafallah, Adham M., Ishida, Wataru, Perdomo-Pantoja, Alexander, Quiñones-Hinojosa, Alfredo, Lim, Michael, Gallia, Gary L., Riggins, Gregory J., Anderson, William S., Sheng-Fu Larry Lo, Rigamonti, Daniele, Tamargo, Rafael J., Witham, Timothy F., Bydon, Ali, Cohen, Alan R., Jallo, George I., Latremoliere, Alban, and Luciano, Mark G.

Published
2022
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