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1,700 results on '"Richards G"'

2. The Karl G. Jansky Very Large Array Sky Survey (VLASS). Science Case and Survey Design

Author

Lacy, M., Baum, S. A., Chandler, C. J., Chatterjee, S., Clarke, T. E., Deustua, S., English, J., Farnes, J., Gaensler, B. M., Gugliucci, N., Hallinan, G., Kent, B. R., Kimball, A., Law, C. J., Lazio, T. J. W., Marvil, J., Mao, S. A., Medlin, D., Mooley, K., Murphy, E. J., Myers, S., Osten, R., Richards, G. T., Rosolowsky, E., Rudnick, L., Schinzel, F., Sivakoff, G. R., Sjouwerman, L. O., Taylor, R., White, R. L., Wrobel, J., Andernach, H., Beasley, A. J., Berger, E., Bhatnager, S., Birkinshaw, M., Bower, G. C., Brandt, W. N., Brown, S., Burke-Spolaor, S., Butler, B. J., Comerford, J., Demorest, P. B., Fu, H., Giacintucci, S., Golap, K., Güth, T., Hales, C. A., Hiriart, R., Hodge, J., Horesh, A., Ivezić, Ž., Jarvis, M. J., Kamble, A., Kassim, N., Liu, X., Loinard, L., Lyons, D. K., Masters, J., Mezcua, M., Moellenbrock, G. A., Mroczkowski, T., Nyland, K., O’Dea, C. P., O’Sullivan, S. P., Peters, W. M., Radford, K., Rao, U., Robnett, J., Salcido, J., Shen, Y., Sobotka, A., Witz, S., Vaccari, M., van Weeren, R. J., Vargas, A., Williams, P. K. G., and Yoon, I.

Published
2020

3. Detection of the Crab Nebula with the 9.7 m prototype Schwarzschild-Couder telescope

Author

Adams, C.B., Alfaro, R., Ambrosi, G., Ambrosio, M., Aramo, C., Arlen, T., Batista, P.I., Benbow, W., Bertucci, B., Bissaldi, E., Biteau, J., Bitossi, M., Boiano, A., Bonavolontà, C., Bose, R., Bouvier, A., Brill, A., Brown, A.M., Buckley, J.H., Byrum, K., Cameron, R.A., Canestrari, R., Capasso, M., Caprai, M., Covault, C.E., Depaoli, D., Errando, M., Fegan, S., Feng, Q., Fiandrini, E., Foote, Juniper, Fortin, P., Funk, S., Furniss, A., Garfias, F., Gent, A., Giglietto, N., Giordano, F., Giro, E., González, M.M., Guarino, V., Halliday, R., Hervet, O., Holder, J., Hughes, G., Humensky, T.B., Ionica, M., Iriarte, A., Jin, W., Johnson, C.A., Kaaret, P., Kieda, D., Kim, B., Kuznetsov, A., Lapington, J.S., Licciulli, F., Loporchio, S., Masone, V., Meagher, K., Meures, T., Mode, B.A.W., Mognet, S.A.I., Mukherjee, R., Nguyen, T., Nieto, D., Okumura, A., Otte, N., La Palombara, N., Pantaleo, F.R., Paoletti, R., Pareschi, G., Petrashyk, A., Di Pierro, F., Pueschel, E., Reynolds, P.T., Ribeiro, D., Richards, G., Roache, E., Ross, D., Rousselle, J., Rugliancich, A., Ruíz-Díaz-Soto, J., Santander, M., Schlenstedt, S., Schneider, M., Scuderi, S., Shang, R., Sironi, G., Stevenson, B., Stiaccini, L., Tajima, H., Taylor, L.P., Thornhill, J., Tosti, L., Tovmassian, G., Vagelli, V., Valentino, M., Vandenbroucke, J., Vassiliev, V.V., Di Venere, L., Wakely, S.P., Watson, J.J., White, R., Wilcox, P., Williams, D.A., Wood, M., Yu, P., and Zink, A.

Published
2021
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4. Paramedic utility in screening patients who present to Emergency Medical Services and who may benefit from an Advance Care Plan: A mixed methods study with explanatory sequential design.

Author

Kirby, K., Liddiard, C., Pocock, L., Black, S., Diaper, A., Goodwin, L., Mensah, T., Proctor, A., Richards, G., Taylor, H., Voss, S., and Benger, J.

Subjects
PATIENTS, IDENTIFICATION, RESEARCH funding, EMERGENCY medical technicians, EMERGENCY medical services, DESCRIPTIVE statistics, ATTITUDES of medical personnel, RESEARCH methodology, MEDICAL screening, TERMINALLY ill, PHENOMENOLOGY, TERMINAL care, ADVANCE directives (Medical care), MEDICAL referrals
Abstract

We used a two-phased mixed methods study with an explanatory sequential design to understand how frequently paramedics attend patients who, on paramedic assessment with the Gold Standards Framework Proactive Identification Guidance, are end-of-life and have advance care planning. We subsequently explored paramedic views on paramedic screening of patients to assess if they are end-of-life and onward referral to their General Practitioner for advance care planning. Paramedics screened and recorded 14.9% of patients as end-of-life and 44.3% of these patients were assessed to have no advance care plan in place. When paramedics screened patients and they did have an advance care plan in place, 36.8% had only a Do Not Attempt Cardiopulmonary Resuscitation. Paramedics found using the Gold Standards Framework Proactive Identification Guidance to screen patients for end-of-life status useful and straightforward and considered themselves well-placed to complete this task. Future research is required to address the practicalities of implementing a paramedic screening and referral tool for end-of-life care that results in the intended outcome of supporting effective advance care planning. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Demonstration of stellar intensity interferometry with the four VERITAS telescopes

Author

Abeysekara, A. U., Benbow, W., Brill, A., Buckley, J. H., Christiansen, J. L., Chromey, A. J., Daniel, M. K., Davis, J., Falcone, A., Feng, Q., Finley, J. P., Fortson, L., Furniss, A., Gent, A., Giuri, C., Gueta, O., Hanna, D., Hassan, T., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Kaaret, P., Kertzman, M., Kieda, D., Krennrich, F., Kumar, S., LeBohec, T., Lin, T. T. Y., Lundy, M., Maier, G., Matthews, N., Moriarty, P., Mukherjee, R., Nievas-Rosillo, M., O’Brien, S., Ong, R. A., Otte, A. N., Pfrang, K., Pohl, M., Prado, R. R., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Ribeiro, D., Richards, G. T., Roache, E., Ryan, J. L., Santander, M., Sembroski, G. H., Wakely, S. P., Weinstein, A., Wilcox, P., Williams, D. A., and Williamson, T. J.

Published
2020
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9. Direct measurement of stellar angular diameters by the VERITAS Cherenkov telescopes

Author

Benbow, W., Bird, R., Brill, A., Brose, R., Chromey, A. J., Daniel, M. K., Feng, Q., Finley, J. P., Fortson, L., Furniss, A., Gillanders, G. H., Giuri, C., Gueta, O., Hanna, D., Halpern, J. P., Hassan, T., Holder, J., Hughes, G., Humensky, T. B., Joyce, A. M., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Kieda, D., Krause, M., Lang, M. J., Lin, T. T. Y., Maier, G., Matthews, N., Moriarty, P., Mukherjee, R., Nieto, D., Nievas-Rosillo, M., O’Brien, S., Ong, R. A., Park, N., Petrashyk, A., Pohl, M., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rulten, C., Sadeh, I., Santander, M., Sembroski, G. H., Shahinyan, K., Sushch, I., Wakely, S. P., Wells, R. M., Wilcox, P., Wilhelm, A., Williams, D. A., and Williamson, T. J.

Published
2019
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11. Probing the structure of the lensed quasar SDSS J1004+4112 through microlensing analysis of spectroscopic data.

Author

Fian, C., Muñoz, J. A., Forés-Toribio, R., Mediavilla, E., Jiménez-Vicente, J., Chelouche, D., Kaspi, S., and Richards, G. T.

Subjects
QUASARS, DATA analysis, ACCRETION disks, STATISTICAL models, GRAVITATIONAL lenses
Abstract

Aims. We aim to reveal the sizes of the continuum and broad emission line (BEL) emitting regions in the gravitationally lensed quasar SDSS J1004+4112 by analyzing the unique signatures of microlensing in this system. Through a comprehensive analysis of 20 spectroscopic observations acquired between 2003 and 2018, we studied the striking deformations of various BEL profiles and determined the sizes of their respective emitting regions. Methods. Our approach involves a detailed analysis of the magnitude differences in the BEL wings and their adjacent continua, and the implementation of a statistical model to quantify the distribution and impact of microlensing magnifications. To ensure a reliable baseline for no microlensing, we used the emission line cores as a reference. We then applied a Bayesian estimate to derive the size lower limits of the Lyα, Si IV, C IV, C III], and Mg II emitting regions, as well as the sizes of the underlying continuum-emitting sources. Results. We analyzed the outstanding microlensing-induced distortions in the line profiles of various BELs in the quasar image A, characterized by a prominent magnification of the blue part and a strong demagnification of the red part. From the statistics of microlensing magnifications and using Bayesian methods, we estimate the lower limit to the overall size of the regions emitting the BELs to be a few light-days across, which is significantly smaller than in typically lensed quasars. The asymmetric deformations in the BELs indicate that the broad-line region is generally not spherically symmetric, and is likely confined to a plane and following the motions of the accretion disk. Additionally, the inferred continuum-emitting region sizes are larger than predictions based on standard thin-disk theory by a factor of ∼3.6 on average. The size-wavelength relation is consistent with that of a geometrically thin and optically thick accretion disk. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Allergic rhinitis: Review of the diagnosis and management: South African Allergic Rhinitis Working Group.

Author

Richards, G. A., McDonald, M., Gray, C. L., de Waal, P., Friedman, R., Hockman, M., Karabus, S. J., Lodder, C. M., Mabelane, T., Mosito, S. M., Nanan, A., Peter, J. G., Quitter, T. H. C., Seedat, R., den Berg, Svan, van Niekerk, A., Vardas, E., and Feldman, C.

Subjects
RHINITIS treatment, ALLERGENS, ADRENOCORTICAL hormones, OTITIS media, PHYSIOLOGIC salines, DIFFERENTIAL diagnosis, DISEASE management, IMMUNOTHERAPY, SINUSITIS, ALLERGIC rhinitis, SEASONAL variations of diseases, RHINITIS, ANTIHISTAMINES, QUALITY of life, DISEASE susceptibility, ASTHMA, COMORBIDITY
Abstract

Background: Allergic rhinitis (AR) has a significant impact on the community as a whole with regard to quality of life and its relationship to allergic multi-morbidities. Appropriate diagnosis, treatment and review of the efficacy of interventions can ameliorate these effects. Yet, the importance of AR is often overlooked, and appropriate therapy is neglected. The availability of effective medications and knowledge as to management are often lacking in both public and private health systems. Methods: This review is based on a comprehensive literature search and detailed discussions by the South African Allergic Rhinitis Working Group (SAARWG). Results: The working group provided up-to-date recommendations on the epidemiology, pathology, diagnosis and management of AR, appropriate to the South African setting. Conclusion: Allergic rhinitis causes significant, often unappreciated, morbidity. It is a complex disease related to an inflammatory response to environmental allergens. Therapy involves education, evaluation of allergen sensitisation, pharmacological treatment, allergen immunotherapy (AIT) and evaluation of the success of interventions. Regular use of saline; the important role of intranasal corticosteroids, including those combined with topical antihistamines and reduction in the use of systemic steroids are key. Practitioners should have a thorough knowledge of associated morbidities and the need for specialist referral. Contribution: This review summarises the latest developments in the diagnosis and management of AR such that it is a resource that allows easy access for family practitioners and specialists alike. [ABSTRACT FROM AUTHOR]

Published
2024

13. Core competencies in critical care for general medical practitioners in South Africa: A Delphi study.

Author

Maasdorp, S. D., Paruk, F., de Vasconcellos, K., Grion, C., Joubert, I., Joynt, G. M., Kalafatis, N., Lapinsky, S. E., Lipman, J., Malbrain, M. L. N. G., Mrara, B., Richards, G. A., Spruyt, M. G. L., van der Merwe, E., Vincent, J. L., and van der Merwe, L. J.

Subjects
PUBLIC hospitals, CONSENSUS (Social sciences), MEDICAL personnel, CLINICAL competence, DELPHI method, EXPERTISE, CRITICAL care medicine
Abstract

Background. Despite a high burden of disease that requires critical care services, there are a limited number of intensivists in South Africa (SA). Medical practitioners at district and regional public sector hospitals frequently manage critically ill patients in the absence of intensivists, despite these medical practitioners having had minimal exposure to critical care during their undergraduate training. Objectives. To identify core competencies in critical care for medical practitioners who provide critical care services at public sector hospitals in SA where intensivists are not available to direct patient management. Methods. A preliminary list of core competencies in critical care was compiled. Thereafter, 13 national and international experts were requested to achieve consensus on a final list of core competencies that are required for critical care by medical practitioners, using a modified Delphi process. Results. A final list of 153 core competencies in critical care was identified. Conclusion. The core competencies identified by this study could assist in developing training programmes for medical practitioners to improve the quality of critical care services provided at district and regional hospitals in SA. [ABSTRACT FROM AUTHOR]

Published
2023
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14. South African guidelines on the determination of death

Author

Thomson, D, Jouber, I, De Vasconcellos, K, Paruk, F, Mokogong, S, Mathivha, R, McCulloch, M, Morrow, B, Baker, D, Rossouw, B, Mdladla, N, Richards, G A, Welkovics, N, Levy, B, Coetzee, I, Spruyt, M, Ahmed, N, and Gopalan, D

Abstract

Death is a medical occurrence that has social, legal, religious and cultural consequences requiring common clinical standards for its diagnosis and legal regulation. This document compiled by the Critical Care Society of Southern Africa outlines the core standards for determination of death in the hospital context. It aligns with the latest evidence-based research and international guidelines and is applicable to the South African context and legal system. The aim is to provide clear medical standards for healthcare providers to follow in the determination of death, thereby promoting safe practices and high-quality care through the use of uniform standards. Adherence to such guidelines will provide assurance to medical staff, patients, their families and the South African public that the determination of death is always undertaken with diligence, integrity, respect and compassion, and is in accordance with accepted medical standards and latest scientific evidence. The consensus guidelines were compiled using the AGREE II checklist with an 18-member expert panel participating in a three-round modified Delphi process. Checklists and advice sheets were created to assist with application of these guidelines in the clinical environment (https://criticalcare.org.za/resource/death-determination-checklists/). Key points • Brain death and circulatory death are the accepted terms for defining death in the hospital context.• Death determination is a clinical diagnosis which can be made with complete certainty provided that all preconditions are met.• The determination of death in children is held to the same standard as in adults but cannot be diagnosed in children

Published
2023

15. Critical Care Society of Southern Africa adult patient blood management guidelines: 2019 Round-table meeting, CCSSA Congress, Durban, 2018

Author

Wise, R D, de Vasconcellos, K, Gopalan, D, Ahmed, N, Alli, A, Joubert, I, Kabambi, K F, Mathiva, L R, Mdladla, N, Mer, M, Miller, M, Mrara, B, Omar, S, Paruk, F, Richards, G A, Skinner, D, and von Rahden, R

Abstract

The CCSSA PBM Guidelines have been developed to improve patient blood management in critically ill patients in southern Africa. These consensus recommendations are based on a rigorous process by experts in the field of critical care who are also practicing in South Africa (SA). The process comprised a Delphi process, a round-table meeting (at the CCSSA National Congress, Durban, 2018), and a review of the best available evidence and international guidelines. The guidelines focus on the broader principles of patient blood management and incorporate transfusion medicine (transfusion guidelines), management of anaemia, optimisation of coagulopathy, and administrative and ethical considerations. There are a mix of low-middle and high-income healthcare structures within southern Africa. Blood products are, however, provided by the same notfor-profit non-governmental organisations to both private and public sectors. There are several challenges related to patient blood management in SA due most notably to a high incidence of anaemia, a frequent shortage of blood products, a small donor population, and a healthcare system under financial strain. The rational and equitable use of blood products is important to ensure best care for as many critically ill patients as possible. The summary of the recommendations provides key practice points for the day-to-day management of critically ill patients. A more detailed description of the evidence used to make these recommendations follows in the full clinical guidelines section.

Published
2023

16. Allergic rhinitis: review of the diagnosis and management: South African Allergic Rhinitis Working Group.

Author

Richards, G. A., McDonald, M., Gray, C. L., de Waal, P., Friedman, R., Hockman, M., Karabus, S. J., Lodder, C. M., Mabelane, T., Mosito, S. M., Nanan, A., Peter, J. G., Quitter, T. H. C., Seedat, R., van den Berg, S., van Niekerk, A., Vardas, E., and Feldman, C.

Subjects
*ALLERGIC rhinitis, *INTRANASAL medication, *IMMUNOTHERAPY, *CORTICOSTEROIDS, *EPIDEMIOLOGY
Abstract

Background: Allergic rhinitis (AR) has a significant impact on the community as a whole with regard to quality of life and its relationship to allergic multi-morbidities. Appropriate diagnosis, treatment and review of the efficacy of interventions can ameliorate these effects. Yet, the importance of AR is often overlooked, and appropriate therapy is neglected. The availability of effective medications and knowledge as to management are often lacking in both public and private health systems. Methods: This review is based on a comprehensive literature search and detailed discussions by the South African Allergic Rhinitis Working Group (SAARWG). Results: The working group provided up-to-date recommendations on the epidemiology, pathology, diagnosis and management of AR, appropriate to the South African setting. Conclusion: Allergic rhinitis causes significant, often unappreciated, morbidity. It is a complex disease related to an inflammatory response to environmental allergens. Therapy involves education, evaluation of allergen sensitisation, pharmacological treatment, allergen immunotherapy (AIT) and evaluation of the success of interventions. Regular use of saline; the important role of intranasal corticosteroids (INCS), including those combined with topical antihistamines and reduction in the use of systemic steroids are key. Practitioners should have a thorough knowledge of associated morbidities and the need for specialist referral. Contribution: This review summarises the latest developments in the diagnosis and management of AR such that it is a resource that allows easy access for family practitioners and specialists alike. [ABSTRACT FROM AUTHOR]

Published
2023

17. Risk factors and outcomes of sepsis-associated acute kidney injury in intensive care units in Johannesburg, South Africa

Author

Mweene, M D, Richards, G A, Paget, G, Banda, J, and Dickens, C

Abstract

Background. Sepsis-associated acute kidney injury (SA-AKI) has been shown to be a significant contributor to morbidity and mortality in both children and adults with critical illness. In sub-Saharan Africa, there is a lack of information on factors associated with development of SA-AKI and outcomes after intensive care unit (ICU) admission.Objectives. To assess the rate of SA-AKI, factors associated with its development, and predictors of mortality at 90 days in critically ill patients admitted to the ICU with sepsis.Methods. This was a prospective observational study conducted at two of the biggest teaching hospitals in Johannesburg, South Africa, from 15 February 2016 to 15 February 2020. The study included consecutive patients with confirmed sepsis who were admitted to the ICU within 24 hours of admission to hospital. The primary outcome of the study was development of SA-AKI (defined according to Kidney Disease Improving Global Outcome (KDIGO) criteria), and secondary outcomes were risk factors for SA-AKI and predictors of mortality at 90 days. Multivariate logistic regression analysis was employed to determine the factors associated with SA-AKI and 90-day mortality.Results. In total, 327 critically ill patients with sepsis admitted to the ICUs were included in the study. The median (interquartile range) age was 39 (30 - 52) years, and 185 patients (56.6%) developed SA-AKI. Of these patients, blacks and whites comprised 91.0% and 6.1%, respectively, and the prevalent comorbidities were HIV/AIDS (19.3%), hypertension (14.2%) and diabetes mellitus (10.1%). Patients with SA-AKI were likely to be older and of male gender, and to have cardiovascular disease, malignancies, hypotension and a low serum albumin level. In multivariate analysis, the predictors of SA-AKI were age ≥55 years (odds ratio (OR) 2.43; 95% confidence interval (CI) 1.27 - 4.65), inotropic support (OR 3.61; 95% CI 2.18 - 5.96) and a low serum albumin level (OR 2.93; 95% CI 1.40 - 6.13). SA-AKI and need for inotropic support were respectively associated with 1.9-fold and 1.7-fold increased mortality at 90 days after ICU admission.Conclusion. SA-AKI was found to be frequent in this study in two tertiary hospital ICUs in Johannesburg, and the need for inotropic support predicted mortality after ICU admission.

Published
2023

18. David Sackett Fellowship 2022: CEBM Report to the McCall MacBain Foundation

Author

Richards, G, Gill, PJ, O'Neill, B, Davis, R, and Heneghan, C

Abstract

We are delighted to report on the success of the inaugural David Sackett Fellowship, building on the success of the 2019 Doug Altman Scholarship, with generous funding and support from the McCall MacBain Foundation (MMF). We used the funding for nine forward-thinking future leaders in Evidence-Based Medicine (EBM) to attend the 2022 EBMLive Conference in Oxford. The nine Fellows brought provocative, bold, and constructive contributions on the theme of making research relevant, replicable, and accessible to end-users. From a highly competitive field, we selected the scholars because of their forward-thinking solutions to address the issue of making research evidence relevant, replicable, and accessible to end-users, as set out in the EBM manifesto, building on the legacy of David Sackett. After an unanticipated delay in hosting EBMLive in 2020 due to the COVID-19 pandemic, the return to an in-person meeting in Oxford, where David Sackett first founded the Centre for Evidence-Based Medicine, re-invigorated the EBM movement with their ideas, enthusiasm, and perspectives. This report highlights the contributions of the awardees, their outputs and the work of the CEBM that supports early-mid career researchers and builds capacity in EBM globally.

Published
2023

19. Ten simple rules for implementing open and reproducible research practices after attending a training course

Author

Heise, V., Holman, C., Lo, H., Lyras, E.M., Adkins, M.C., Aquino, M.R.J., Bougioukas, K.I., Bray, K.O., Gajos, M., Guo, X., Hartling, C., Huerta-Gutierrez, R., Jindrová, M., Kenney, J.P.M., Kępińska, A.P., Kneller, L., Lopez-Rodriguez, E., Mühlensiepen, F., Richards, A., Richards, G., Siebert, M., Smith, J.A., Smith, N., Stransky, N., Tarvainen, S., Valdes, D.S., Warrington, K.L., Wilpert, N.M., Witkowska, D., Zaneva, M., Zanker, J., and Weissgerber, T.L.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

Open, reproducible, and replicable research practices are a fundamental part of science. Training is often organized on a grassroots level, offered by early career researchers, for early career researchers. Buffet style courses that cover many topics can inspire participants to try new things; however, they can also be overwhelming. Participants who want to implement new practices may not know where to start once they return to their research team. We describe ten simple rules to guide participants of relevant training courses in implementing robust research practices in their own projects, once they return to their research group. This includes (1) prioritizing and planning which practices to implement, which involves obtaining support and convincing others involved in the research project of the added value of implementing new practices; (2) managing problems that arise during implementation; and (3) making reproducible research and open science practices an integral part of a future research career. We also outline strategies that course organizers can use to prepare participants for implementation and support them during this process.

Published
2023

21. South African guidelines on the determination of death

Author

Baker, D, Gopalan, D, Ahmed, N, Spruyt, M, Coetzee, I, Levy, B, Welkovics, N, Richards, G A, Mdladla, N, Rossouw, B, Thomson, D, Morrow, B, McCulloch, M, Mathivha, R, Mokogong, S, Paruk, F, De Vasconcellos, K, and Joubert, I

Abstract

Death is a medical occurrence that has social, legal, religious and cultural consequences requiring common clinical standards for its diagnosis and legal regulation. This document compiled by the Critical Care Society of Southern Africa outlines the core standards for determination of death in the hospital context. It aligns with the latest evidence-based research and international guidelines and is applicable to the South African context and legal system. The aim is to provide clear medical standards for healthcare providers to follow in the determination of death, thereby promoting safe practices and high-quality care through the use of uniform standards. Adherence to such guidelines will provide assurance to medical staff, patients, their families and the South African public that the determination of death is always undertaken with diligence, integrity, respect and compassion, and is in accordance with accepted medical standards and latest scientific evidence. The consensus guidelines were compiled using the AGREE II checklist with an 18-member expert panel participating in a three-round modified Delphi process. Checklists and advice sheets were created to assist with application of these guidelines in the clinical environment (https://criticalcare.org.za/resource/death-determination-checklists/).Key points• Brain death and circulatory death are the accepted terms for defining death in the hospital context.• Death determination is a clinical diagnosis which can be made with complete certainty provided that all preconditions are met.• The determination of death in children is held to the same standard as in adults but cannot be diagnosed in children

Published
2022

22. Clinical features and outcomes of patients with myasthenia gravis admitted to an intensive care unit: A 20-year retrospective study.

Author

Morar, R., Amod, M., Chappel, F., Ebbeling, L., Fikizolo, L., Glover, A., Gutu, K., Lawson, C., Maswinyaneng, R., Mohunlal, M., Morar, K., Rooken-Smith, D., Seale, K., Shai, D., Seedat, F., and Richards, G. A.

Subjects
MYASTHENIA gravis treatment, INTENSIVE care units, MYASTHENIA gravis, ACADEMIC medical centers, ADRENOCORTICAL hormones, AZATHIOPRINE, RETROSPECTIVE studies, ACQUISITION of data, DISEASES, ASPIRATION pneumonia, IATROGENIC diseases, TREATMENT effectiveness, EXTUBATION, INTRAVENOUS immunoglobulins, HOSPITAL mortality, CRITICAL care medicine, MEDICAL records, DESCRIPTIVE statistics, PLASMAPHERESIS, PNEUMOTHORAX, DISEASE management, DISEASE risk factors, SYMPTOMS
Abstract

Background. There are limited data on the clinical characteristics and outcomes of patients with myasthenia gravis (MG) admitted to the intensive care unit (ICU) at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH). Objectives. The aim was to study the clinical characteristics and outcomes of patients with MG admitted to the CMJAH over two decades. Methods. A retrospective study was undertaken of patients with MG admitted to the multidisciplinary ICU of CMJAH over a 20-year period, from 1998 to 2017. Demographic data, clinical features, management and outcomes of patients were assessed and reviewed from the case records. Results. Thirty-four patients with MG were admitted to the ICU during this period: 24 female and 10 male. The mean age ± SD was 37.4 ± 13.0 years, with a range of 16 - 66 years. Four patients were human immunodeficiency virus (HIV)-positive. The mean length of stay (LOS) in ICU was 10.6 ± 20.1 days, ranging from 1 to 115 days. Two patients were diagnosed with MG in the ICU after failure to wean from the ventilator. Overall, 22 patients were intubated and ventilated on admission. Morbidities included self-extubation, aspiration pneumonia and iatrogenic pneumothorax. History of thymectomy was present in 12 patients. The treatments received for MG included pyridostigmine (73.5%), corticosteroids (55.9%), azathioprine (35.3%), plasmapheresis (26.5%) and intravenous immunoglobulin (8.8%). The overall mortality in the ICU was 5.9%. Conclusion. MG is a serious disorder with considerable morbidity and mortality. It is, however, a potentially manageable disease, provided that appropriate ICU resources are available. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: 'AbSeS', a multinational observational cohort study and ESICM Trials Group Project

Author

Blot, S. aEmail Author, Antonelli M. b, c Arvaniti, K. d Blot, K. a Creagh-Brown, B. e f, de Lange, D. g, De Waele, J. h Deschepper, M. i Dikmen, Y. j Dimopoulos, G. k Eckmann, C. l Francois, G. m Girardis, M. n Koulenti, D. o p, Labeau S. a, q Lipman, J. r s, Lipovestky F. t, Maseda E. u, Montravers P. v, w Mikstacki, A. x y, Paiva, J. -A. z, Pereyra, C. aa, Rello, J. ab, Timsit, J. -F. ac, ad Vogelaers, D. ae, Lamrous A., Rezende-Neto J., Cardenas Y., Vymazal T., Fjeldsoee-Nielsen H., Kott M., Kostoula A., Javeri Y., Einav S., Makikado L. D. U., Tomescu D., Gritsan A., Jovanovic B., Venkatesan K., Mirkovic T., Creagh-Brown B., Emmerich M., Canale M., Dietz L. S., Ilutovich S., Miñope J. T. S., Silva R. B., Montenegro M. A., Martin P., Saul P., Chediack V., Sutton G., Couce R., Balasini C., Gonzalez S., Lascar F. M., Descotte E. J., Gumiela N. S., Pino C. A., Cesio C., Valgolio E., Cunto E., Dominguez C., Nelson N. F., Abegao E. M., Pozo N. C., Bianchi L., Correger E., Pastorino M. L., Miyazaki E. A., Grubissich N., Garcia M., Bonetto N., Quevedo N. E., Gomez C. D., Queti F., Estevarena L. G., Fernandez R., Santolaya I., Grangeat S. H., Doglia J., Zakalik G., Pellegrini C., Lloria M. M., Chacon M. E., Fumale M., Leguizamon M., Hidalgo I. B., Tiranti R. J., Capponi P., Tita A., Cardonnet L., Bettini L., Ramos A., Lovesio L., Miranda E. M., Farfan A. B., Tolosa C., Segura L., Bellocchio A., Alvarez B., Manzur A., Lujan R., Fernandez N., Scarone N., Zazu A., Groh C., Fletcher J., Smith J., Azad R., Chavan N., Wong H., Kol M., Campbell L., Starr T., Roberts B., Wibrow B., Warhurst T., Chinthamuneedi M., Ferney B. B., Simon M., De Backer, D. Wittebole, De Bels, D. Collin, V. Dams, K. Jorens, P. Dubois, J. Gunst, J. Haentjens, De Schryver, N. Dugernier, T. Rezende-Neto, J. Rizoli, S. Santillan, P. Han, Y. Biskup, E. Qu, C. Li, X. Yu, T. Weihua, L. Molano-Franco, D. Rojas, J. Oviedo, J. M. P. Pinilla, D. Cardenas, Y. Celis, E. Arias, M. Vukovic, A. Vudrag, M. Belavic, M. Zunic, J. Kuharic, J. Kricka, I. B. Filipovic-Grcic, I. Tomasevic, B. Obraz, M. Bodulica, B. Dohnal, M. Malaska, J. Kratochvil, M. Satinsky, I. Schwarz, P. Kos, Z. Blahut, L. Maca, J. Protus, M. Kieslichová, E. Nielsen, L. G. Krogh, B. M. Rivadeneira, F. Morales, F. Mora, J. Orozco, A. S. MorochoTutillo, D. R. Vargas, N. R. Yepez, E. S. Villamagua, B. Alsisi, A. Fahmy, A. Dupont, H. Lasocki, S. Paugam-Burtz, C. Foucrier, A. Nica, A. Barjon, G. Mallat, J. Marcotte, G. Leone, M. Duclos, G. Burtin, P. Atchade, E. Mahjoub, Y. Misset, B. Timsit, J. -F., Dupuis C., Veber B., Debarre M., Collange O., Pottecher J., Hecketsweiler S., Fromentin M., Tesnière A., Koch C., Sander M., Elke G., Wrigge H., Simon P., Chalkiadaki A., Tzanidakis C., Pneumatikos I., Sertaridou E., Mastora Z., Pantazopoulos I., Papanikolaou M., Papavasilopoulou T., Floros J., Kolonia V., Diakaki C., Rallis M., Paridou A., Kalogeromitros A., Romanou V., Nikolaou C., Kounougeri K., Tsigou E., Psallida V., Karampela N., Mandragos K., Kontoudaki E., Pentheroudaki A., Farazi-Chongouki C., Karakosta A., Chouris I., Radu V., Malliotakis P., Kokkini S., Charalambous E., Kyritsi A., Koulouras V., Papathanakos G., Nagky E., Lampiri C., Tsimpoukas F., Sarakatsanos I., Georgakopoulos P., Ravani I., Prekates A., Sakellaridis K., Christopoulos C., Vrettou E., Stokkos K., Pentari A., Marmanidou K., Kydona C., Tsoumaropoulos G., Bitzani M., Kontou P., Voudouris A., Elli-Nikki Flioni, Antypa E., Chasou E., Anisoglou S., Papageorgiou E., Paraforou T., Tsioka A., Karathanou A., Vakalos A., Shah B., Thakkar C., Jain N., Gurjar M., Baronia A., Sathe P., Kulkarni S., Paul C., Paul J., Masjedi M., Nikandish R., Zand F., Sabetian G., Mahmoodpoor A., Hashemian S. M., Bala M., Flocco R., Torrente S., Pota V., Spadaro S., Volta C., Serafini G., Boraso S., Tiberio I., Cortegiani A., Misseri G., Barbagallo M., Nicolotti D., Forfori F., Corradi F., De Pascale, G. Pelagalli, L. Brazzi, L. Vittone, F. G. Russo, A. Simion, D. Cotoia, A. Cinnella, G. Toppin, P. Johnson-Jackson, R. Hayashi, Y. Yamamoto, R. Yasuda, H. Kishihara, Y. Shiotsuka, J. Sanchez-Hurtado, L. A. Tejeda-Huezo, B. Gorordo, L. Ñamendys-Silva, S. A. Garcia-Guillen, F. J. Martinez, M. Romero-Meja, E. Colorado-Dominguez, van den Oever, H. Kalff, K. M. Vermeijden, W. Cornet, A. D. Beck, O. Cimic, N. Dormans, T. Bormans, L. Bakker, Van Duijn, D. Bosman, G. Vos, P. Haas, L. Henein, A. Miranda, A. M. Makikado, L. D. U. Malca, G. E. G. Arroyo-Sanchez, A. Misiewska-Kaczur, A. Akinyi, F. Czuczwar, M. Luczak, K. Sulkowski, W. Tamowicz, B. Swit, B. Baranowski, B. Smuszkiewicz, P. Trojanowska, I. Rzymski, S. Sawinski, M. Trosiak, M. Mikaszewska-Sokolewicz, M. Alves, R. Leal, D. Krystopchuk, A. Mendonca, P. M. H. Pereira, R. A., de Carvalho, M. R. L. M. Candeias, C. Molinos, E. Ferreira, A. Castro, G. Pereira, J. -M., Santos L., Ferreira A., Pascoalinho D., Ribeiro R., Domingos G., Gomes P., Nora D., Costa R. P., Santos A., Alsheikhly A. S., Popescu M., Grigoras I., Patrascanu E., Zabolotskikh I., Musaeva T., Gaigolnik D., Kulabukhov V., Belskiy V., Zubareva N., Tribulev M., Abdelsalam A., Aldarsani A., Al-Khalid M., Almekhlafi G., Mandourah Y., Doklestic K., Velickovic J., Velickovic D., Jankovic R., Vukovic A., Skoric-Jokic S., Radovanovic D., Richards G., Alli A., del Carmen Cordoba Nielfa, M. Iniesta, R. S. Martínez, A. B. -C., Bernedo C. G., Gil S. A. P., Nuvials X., Garcia J. G., Peña J. M. G., Jimenez R., Herrera L., Barrachina L. G., Monzon I. C., Redondo F. J., Villazala R., Zapata D. F. M., Lopez I. M. V., Moreno-Gonzalez G., Lopez-Delgado J. C., Marin J. S., Sanchez-Zamora P., Vidal M. V., González J. F., Salinas I., Hermosa C., Martinez-Sagasti F., Domingo-Marín S., Victorino J. A., Garcia-Alvarez R., Calleja, P. L. -A., de la Torre-Prados, M. -V., Vidal-Cortes P., del Río-Carbajo, L. Izura, J. Minguez, V. Alvarez, J. T. Prous, A. P. Paz, D. Roche-Campo, F. Aguilar, G. Belda, J. Rico-Feijoo, J. Aldecoa, C. Zalba-Etayo, B. Lang, M. Dullenkopf, A. Trongtrakul, K. Chtsomkasem, A. Akbas, T. Unal, M. N. Ozcelik, M. Gumus, A. Ramazanoglu, A. Memis, D. Mehmet, I. Urkmez, S. Ozgultekin, A. Demirkiran, O. Aslan, N. A. Kizilaslan, D. Kahveci, F. Ünlü, N. Ozkan, Z. Kaye, C. Jansen, J. O’Neill, O. Nutt, C. Jha, R. Hooker, N. Grecu, I. Petridou, C. Shyamsundar, M. McNamee, L. Trinder, J. Hagan, S. Kelly, C. Silversides, J. Groba, C. B. Boyd, O. Bhowmick, K. Humphreys, S. Summers, C. Polgarova, P. Margarson, M. Dickens, J. Pearson, S. Chinery, E. Hemmings, N. O’Kane, S. Austin, P. Cole, S. Plowright, C. Box, R. Wright, C. Young, L. Montague, L. Parker, R. Morton, B. Ostermann, M. Bilinska, J. Rose, B. O. Reece-Anthony, R. Ryan, C. Hamilton, M. Hopkins, P. Wendon, J. Brescia, G. Ijaz, N. Wood, J. George, M. Toth-Tarsoly, P. Yates, B. Armstrong, M. Scott, C. Boyd, C. Szakmany, T. Rees, D. Pulak, P. Coggon, M. Saha, B. Kent, L. Gibson, B. Camsooksai, J. Reschreiter, H. Morgan, P. Sangaralingham, S. Lowe, A. Vondras, P. Jamadarkhana, S. Cruz, C. Bhandary, R. Hersey, P. Furneval, J. Innes, R. Doble, P. Attwood, B. Parsons, P. Page, V. Zhao, X. Grecu, I. Dalton, J. Hegazy, M. Awad, Y. Naylor, D. Naylor, A. Lee, S. Brevard, S. Davis, University of Queensland [Brisbane], Department of Intensive Care and Anesthesiology, Università cattolica del Sacro Cuore [Milano] (Unicatt), University Medical Center [Utrecht], Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Département d'Anesthésie Réanimation, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centro Hospitalar Universitário São João - Faculty of Medicine - University of Porto - Grupo de Infecção e Sepsis, Porto, Critical Care Department, Joan XXIII University Hospital, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, European Soc Intensive Care Med, İÜC, Cerrahpaşa Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, [Blot S, Blot K] Department of Internal Medicine and Pediatrics, Ghent University, Campus UZ Gent, Ghent, Belgium. [Antonelli M] Department of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. Università Cattolica del Sacro Cuore, Rome, Italy. [Arvaniti K] Intensive Care Unit, Papageorgiou University Affiliated Hospital, Thessaloníki, Greece. [Creagh-Brown, B] Surrey Perioperative Anaesthetic Critical Care Collaborative Research Group (SPACeR), Royal Surrey County Hospital, Guildford, UK. Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. [de Lange D] Department of Intensive Care Medicine, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands. [Rello J] Centro de investigación en red de enfermedades respiratorias (CIBERES), Madrid, Spain. Recerca clínica/Innovació en la pneumònia i sèpsia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Ünlü, Nurdan, Kahveci, Ferda, CYR-2043-2022, CHB-0826-2022, Assistance Publique-Hôpitaux de Marseille (AP-HM), Blot S., Antonelli M., Arvaniti K., Blot K., Creagh-Brown B., de Lange D., De Waele J., Deschepper M., Dikmen Y., Dimopoulos G., Eckmann C., Francois G., Girardis M., Koulenti D., Labeau S., Lipman J., Lipovestky F., Maseda E., Montravers P., Mikstacki A., Paiva J.-A., Pereyra C., Rello J., Timsit J.-F., Vogelaers D., Lamrous A., Rezende-Neto J., Cardenas Y., Vymazal T., Fjeldsoee-Nielsen H., Kott M., Kostoula A., Javeri Y., Einav S., Makikado L.D.U., Tomescu D., Gritsan A., Jovanovic B., Venkatesan K., Mirkovic T., Emmerich M., Canale M., Dietz L.S., Ilutovich S., Minope J.T.S., Silva R.B., Montenegro M.A., Martin P., Saul P., Chediack V., Sutton G., Couce R., Balasini C., Gonzalez S., Lascar F.M., Descotte E.J., Gumiela N.S., Pino C.A., Cesio C., Valgolio E., Cunto E., Dominguez C., Nelson N.F., Abegao E.M., Pozo N.C., Bianchi L., Correger E., Pastorino M.L., Miyazaki E.A., Grubissich N., Garcia M., Bonetto N., Quevedo N.E., Gomez C.D., Queti F., Estevarena L.G., Fernandez R., Santolaya I., Grangeat S.H., Doglia J., Zakalik G., Pellegrini C., Lloria M.M., Chacon M.E., Fumale M., Leguizamon M., Hidalgo I.B., Tiranti R.J., Capponi P., Tita A., Cardonnet L., Bettini L., Ramos A., Lovesio L., Miranda E.M., Farfan A.B., Tolosa C., Segura L., Bellocchio A., Alvarez B., Manzur A., Lujan R., Fernandez N., Scarone N., Zazu A., Groh C., Fletcher J., Smith J., Azad R., Chavan N., Wong H., Kol M., Campbell L., Starr T., Roberts B., Wibrow B., Warhurst T., Chinthamuneedi M., Ferney B.B., Simon M., De Backer D., Wittebole X., De Bels D., Collin V., Dams K., Jorens P., Dubois J., Gunst J., Haentjens L., De Schryver N., Dugernier T., Rizoli S., Santillan P., Han Y., Biskup E., Qu C., Li X., Yu T., Weihua L., Molano-Franco D., Rojas J., Oviedo J.M.P., Pinilla D., Celis E., Arias M., Vukovic A., Vudrag M., Belavic M., Zunic J., Kuharic J., Kricka I.B., Filipovic-Grcic I., Tomasevic B., Obraz M., Bodulica B., Dohnal M., Malaska J., Kratochvil M., Satinsky I., Schwarz P., Kos Z., Blahut L., Maca J., Protus M., Kieslichova E., Nielsen L.G., Krogh B.M., Rivadeneira F., Morales F., Mora J., Orozco A.S., MorochoTutillo D.R., Vargas N.R., Yepez E.S., Villamagua B., Alsisi A., Fahmy A., Dupont H., Lasocki S., Paugam-Burtz C., Foucrier A., Nica A., Barjon G., Mallat J., Marcotte G., Leone M., Duclos G., Burtin P., Atchade E., Mahjoub Y., Misset B., Dupuis C., Veber B., Debarre M., Collange O., Pottecher J., Hecketsweiler S., Fromentin M., Tesniere A., Koch C., Sander M., Elke G., Wrigge H., Simon P., Chalkiadaki A., Tzanidakis C., Pneumatikos I., Sertaridou E., Mastora Z., Pantazopoulos I., Papanikolaou M., Papavasilopoulou T., Floros J., Kolonia V., Diakaki C., Rallis M., Paridou A., Kalogeromitros A., Romanou V., Nikolaou C., Kounougeri K., Tsigou E., Psallida V., Karampela N., Mandragos K., Kontoudaki E., Pentheroudaki A., Farazi-Chongouki C., Karakosta A., Chouris I., Radu V., Malliotakis P., Kokkini S., Charalambous E., Kyritsi A., Koulouras V., Papathanakos G., Nagky E., Lampiri C., Tsimpoukas F., Sarakatsanos I., Georgakopoulos P., Ravani I., Prekates A., Sakellaridis K., Christopoulos C., Vrettou E., Stokkos K., Pentari A., Marmanidou K., Kydona C., Tsoumaropoulos G., Bitzani M., Kontou P., Voudouris A., Elli-Nikki, Flioni, Antypa E., Chasou E., Anisoglou S., Papageorgiou E., Paraforou T., Tsioka A., Karathanou A., Vakalos A., Shah B., Thakkar C., Jain N., Gurjar M., Baronia A., Sathe P., Kulkarni S., Paul C., Paul J., Masjedi M., Nikandish R., Zand F., Sabetian G., Mahmoodpoor A., Hashemian S.M., Bala M., Flocco R., Torrente S., Pota V., Spadaro S., Volta C., Serafini G., Boraso S., Tiberio I., Cortegiani A., Misseri G., Barbagallo M., Nicolotti D., Forfori F., Corradi F., De Pascale G., Pelagalli L., Brazzi L., Vittone F.G., Russo A., Simion D., Cotoia A., Cinnella G., Toppin P., Johnson-Jackson R., Hayashi Y., Yamamoto R., Yasuda H., Kishihara Y., Shiotsuka J., Sanchez-Hurtado L.A., Tejeda-Huezo B., Gorordo L., Namendys-Silva S.A., Garcia-Guillen F.J., Martinez M., Romero-Meja E., Colorado-Dominguez E., van den Oever H., Kalff K.M., Vermeijden W., Cornet A.D., Beck O., Cimic N., Dormans T., Bormans L., Bakker J., Van Duijn D., Bosman G., Vos P., Haas L., Henein A., Miranda A.M., Malca G.E.G., Arroyo-Sanchez A., Misiewska-Kaczur A., Akinyi F., Czuczwar M., Luczak K., Sulkowski W., Tamowicz B., Swit B., Baranowski B., Smuszkiewicz P., Trojanowska I., Rzymski S., Sawinski M., Trosiak M., Mikaszewska-Sokolewicz M., Alves R., Leal D., Krystopchuk A., Mendonca P.M.H., Pereira R.A., de Carvalho M.R.L.M., Candeias C., Molinos E., Ferreira A., Castro G., Pereira J.-M., Santos L., Pascoalinho D., Ribeiro R., Domingos G., Gomes P., Nora D., Costa R.P., Santos A., Alsheikhly A.S., Popescu M., Grigoras I., Patrascanu E., Zabolotskikh I., Musaeva T., Gaigolnik D., Kulabukhov V., Belskiy V., Zubareva N., Tribulev M., Abdelsalam A., Aldarsani A., Al-Khalid M., Almekhlafi G., Mandourah Y., Doklestic K., Velickovic J., Velickovic D., Jankovic R., Skoric-Jokic S., Radovanovic D., Richards G., Alli A., del Carmen Cordoba Nielfa M., Iniesta R.S., Martinez A.B.-C., Bernedo C.G., Gil S.A.P., Nuvials X., Garcia J.G., Pena J.M.G., Jimenez R., Herrera L., Barrachina L.G., Monzon I.C., Redondo F.J., Villazala R., Zapata D.F.M., Lopez I.M.V., Moreno-Gonzalez G., Lopez-Delgado J.C., Marin J.S., Sanchez-Zamora P., Vidal M.V., Gonzalez J.F., Salinas I., Hermosa C., Martinez-Sagasti F., Domingo-Marin S., Victorino J.A., Garcia-Alvarez R., Calleja P.L.-A., de la Torre-Prados M.-V., Vidal-Cortes P., del Rio-Carbajo L., Izura J., Minguez V., Alvarez J.T., Prous A.P., Paz D., Roche-Campo F., Aguilar G., Belda J., Rico-Feijoo J., Aldecoa C., Zalba-Etayo B., Lang M., Dullenkopf A., Trongtrakul K., Chtsomkasem A., Akbas T., Unal M.N., Ozcelik M., Gumus A., Ramazanoglu A., Memis D., Mehmet I., Urkmez S., Ozgultekin A., Demirkiran O., Aslan N.A., Kizilaslan D., Kahveci F., Unlu N., Ozkan Z., Kaye C., Jansen J., O'Neill O., Nutt C., Jha R., Hooker N., Grecu I., Petridou C., Shyamsundar M., McNamee L., Trinder J., Hagan S., Kelly C., Silversides J., Groba C.B., Boyd O., Bhowmick K., Humphreys S., Summers C., Polgarova P., Margarson M., Dickens J., Pearson S., Chinery E., Hemmings N., O'Kane S., Austin P., Cole S., Plowright C., Box R., Wright C., Young L., Montague L., Parker R., Morton B., Ostermann M., Bilinska J., Rose B.O., Reece-Anthony R., Ryan C., Hamilton M., Hopkins P., Wendon J., Brescia G., Ijaz N., Wood J., George M., Toth-Tarsoly P., Yates B., Armstrong M., Scott C., Boyd C., Szakmany T., Rees D., Pulak P., Coggon M., Saha B., Kent L., Gibson B., Camsooksai J., Reschreiter H., Morgan P., Sangaralingham S., Lowe A., Vondras P., Jamadarkhana S., Cruz C., Bhandary R., Hersey P., Furneval J., Innes R., Doble P., Attwood B., Parsons P., Page V., Zhao X., Dalton J., Hegazy M., Awad Y., Naylor D., Naylor A., Lee S., Brevard S., Davis N., Blot, Stijn [0000-0003-2145-0345], Apollo - University of Cambridge Repository, Gunst, Jan, Epidemiology, Intensive Care, Blot, S., aEmail Author, Antonelli, M. b., C, Arvaniti, Blot, K. d., Creagh-Brown, K. a., B. e., F, De, Lange, D., G., De, Waele, Deschepper, J. h., Dikmen, M. i., Dimopoulos, Y. j., Eckmann, G. k., Francois, C. l., Girardis, G. m., Koulenti, M. n., D. o., P, Labeau, S. a., Q, Lipman, J. r., S, Lipovestky, F. t., Maseda, E. u., Montravers, P. v., W, Mikstacki, A. x., Y, Paiva, J. -A., Z., Pereyra, C., Aa, Rello, J., Ab, Timsit, J. -F., Ac, Ad, Vogelaer, D., Ae, Lamrous, A., Rezende-Neto, J., Cardenas, Y., Vymazal, T., Fjeldsoee-Nielsen, H., Kott, M., Kostoula, A., Javeri, Y., Einav, S., Makikado, L. D. U., Tomescu, D., Gritsan, A., Jovanovic, B., Venkatesan, K., Mirkovic, T., Creagh-Brown, B., Emmerich, M., Canale, M., Dietz, L. S., Ilutovich, S., Miñope, J. T. S., Silva, R. B., Montenegro, M. A., Martin, P., Saul, P., Chediack, V., Sutton, G., Couce, R., Balasini, C., Gonzalez, S., Lascar, F. M., Descotte, E. J., Gumiela, N. S., Pino, C. A., Cesio, C., Valgolio, E., Cunto, E., Dominguez, C., Nelson, N. F., Abegao, E. M., Pozo, N. C., Bianchi, L., Correger, E., Pastorino, M. L., Miyazaki, E. A., Grubissich, N., Garcia, M., Bonetto, N., Quevedo, N. E., Gomez, C. D., Queti, F., Estevarena, L. G., Fernandez, R., Santolaya, I., Grangeat, S. H., Doglia, J., Zakalik, G., Pellegrini, C., Lloria, M. M., Chacon, M. E., Fumale, M., Leguizamon, M., Hidalgo, I. B., Tiranti, R. J., Capponi, P., Tita, A., Cardonnet, L., Bettini, L., Ramos, A., Lovesio, L., Miranda, E. M., Farfan, A. B., Tolosa, C., Segura, L., Bellocchio, A., Alvarez, B., Manzur, A., Lujan, R., Fernandez, N., Scarone, N., Zazu, A., Groh, C., Fletcher, J., Smith, J., Azad, R., Chavan, N., Wong, H., Kol, M., Campbell, L., Starr, T., Roberts, B., Wibrow, B., Warhurst, T., Chinthamuneedi, M., Ferney, B. B., Simon, M., De, Backer, D., Wittebole, De, Bel, D., Collin, V., Dam, K., Joren, P., Duboi, J., Gunst, J., Haentjen, De, Schryver, N., Dugernier, T., Rezende-Neto, J., Rizoli, S., Santillan, P., Han, Y., Biskup, E., Qu, C., Li, X., Yu, T., Weihua, L., Molano-Franco, D., Roja, J., Oviedo, J. M. P., Pinilla, D., Cardena, Y., Celi, E., Aria, M., Vukovic, A., Vudrag, M., Belavic, M., Zunic, J., Kuharic, J., Kricka, I. B., Filipovic-Grcic, I., Tomasevic, B., Obraz, M., Bodulica, B., Dohnal, M., Malaska, J., Kratochvil, M., Satinsky, I., Schwarz, P., Ko, Z., Blahut, L., Maca, J., Protu, M., Kieslichová, E., Nielsen, L. G., Krogh, B. M., Rivadeneira, F., Morale, F., Mora, J., Orozco, A. S., Morochotutillo, D. R., Varga, N. R., Yepez, E. S., Villamagua, B., Alsisi, A., Fahmy, A., Dupont, H., Lasocki, S., Paugam-Burtz, C., Foucrier, A., Nica, A., Barjon, G., Mallat, J., Marcotte, G., Leone, M., Duclo, G., Burtin, P., Atchade, E., Mahjoub, Y., Misset, B., Timsit, J., -F., Dupuis, C., Veber, B., Debarre, M., Collange, O., Pottecher, J., Hecketsweiler, S., Fromentin, M., Tesnière, A., Koch, C., Sander, M., Elke, G., Wrigge, H., Simon, P., Chalkiadaki, A., Tzanidakis, C., Pneumatikos, I., Sertaridou, E., Mastora, Z., Pantazopoulos, I., Papanikolaou, M., Papavasilopoulou, T., Floros, J., Kolonia, V., Diakaki, C., Rallis, M., Paridou, A., Kalogeromitros, A., Romanou, V., Nikolaou, C., Kounougeri, K., Tsigou, E., Psallida, V., Karampela, N., Mandragos, K., Kontoudaki, E., Pentheroudaki, A., Farazi-Chongouki, C., Karakosta, A., Chouris, I., Radu, V., Malliotakis, P., Kokkini, S., Charalambous, E., Kyritsi, A., Koulouras, V., Papathanakos, G., Nagky, E., Lampiri, C., Tsimpoukas, F., Sarakatsanos, I., Georgakopoulos, P., Ravani, I., Prekates, A., Sakellaridis, K., Christopoulos, C., Vrettou, E., Stokkos, K., Pentari, A., Marmanidou, K., Kydona, C., Tsoumaropoulos, G., Bitzani, M., Kontou, P., Voudouris, A., Elli-Nikki, Flioni, Antypa, E., Chasou, E., Anisoglou, S., Papageorgiou, E., Paraforou, T., Tsioka, A., Karathanou, A., Vakalos, A., Shah, B., Thakkar, C., Jain, N., Gurjar, M., Baronia, A., Sathe, P., Kulkarni, S., Paul, C., Paul, J., Masjedi, M., Nikandish, R., Zand, F., Sabetian, G., Mahmoodpoor, A., Hashemian, S. M., Bala, M., Flocco, R., Torrente, S., Pota, V., Spadaro, S., Volta, C., Serafini, G., Boraso, S., Tiberio, I., Cortegiani, A., Misseri, G., Barbagallo, M., Nicolotti, D., Forfori, F., Corradi, F., De, Pascale, G., Pelagalli, L., Brazzi, L., Vittone, F. G., Russo, A., Simion, D., Cotoia, A., Cinnella, G., Toppin, P., Johnson-Jackson, R., Hayashi, Y., Yamamoto, R., Yasuda, H., Kishihara, Y., Shiotsuka, J., Sanchez-Hurtado, L. A., Tejeda-Huezo, B., Gorordo, L., Ñamendys-Silva, S. A., Garcia-Guillen, F. J., Martinez, M., Romero-Meja, E., Colorado-Dominguez, van den, Oever, H., Kalff, K. M., Vermeijden, W., Cornet, A. D., Beck, O., Cimic, N., Dorman, T., Borman, L., Bakker, Van, Duijn, D., Bosman, G., Vo, P., Haa, L., Henein, A., Miranda, A. M., Makikado, L. D. U., Malca, G. E. 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A. P., Nuvials, X., Garcia, J. G., Peña, J. M. G., Jimenez, R., Herrera, L., Barrachina, L. G., Monzon, I. C., Redondo, F. J., Villazala, R., Zapata, D. F. M., Lopez, I. M. V., Moreno-Gonzalez, G., Lopez-Delgado, J. C., Marin, J. S., Sanchez-Zamora, P., Vidal, M. V., González, J. F., Salinas, I., Hermosa, C., Martinez-Sagasti, F., Domingo-Marín, S., Victorino, J. A., Garcia-Alvarez, R., Calleja, P. L., -A., de la, Torre-Prado, M., -V., Vidal-Cortes, P., Del, Río-Carbajo, L., Izura, J., Minguez, V., Alvarez, J. T., Prou, A. P., Paz, D., Roche-Campo, F., Aguilar, G., Belda, J., Rico-Feijoo, J., Aldecoa, C., Zalba-Etayo, B., Lang, M., Dullenkopf, A., Trongtrakul, K., Chtsomkasem, A., Akba, T., Unal, M. N., Ozcelik, M., Gumu, A., Ramazanoglu, A., Memi, D., Mehmet, I., Urkmez, S., Ozgultekin, A., Demirkiran, O., Aslan, N. A., Kizilaslan, D., Kahveci, F., Ünlü, N., Ozkan, Z., Kaye, C., Jansen, J., O’Neill, O., Nutt, C., Jha, R., Hooker, N., Grecu, I., Petridou, C., Shyamsundar, M., Mcnamee, L., Trinder, J., Hagan, S., Kelly, C., Silverside, J., Groba, C. B., Boyd, O., Bhowmick, K., Humphrey, S., Summer, C., Polgarova, P., Margarson, M., Dicken, J., Pearson, S., Chinery, E., Hemming, N., O’Kane, S., Austin, P., Cole, S., Plowright, C., Box, R., Wright, C., Young, L., Montague, L., Parker, R., Morton, B., Ostermann, M., Bilinska, J., Rose, B. O., Reece-Anthony, R., Ryan, C., Hamilton, M., Hopkin, P., Wendon, J., Brescia, G., Ijaz, N., Wood, J., George, M., Toth-Tarsoly, P., Yate, B., Armstrong, M., Scott, C., Boyd, C., Szakmany, T., Ree, D., Pulak, P., Coggon, M., Saha, B., Kent, L., Gibson, B., Camsooksai, J., Reschreiter, H., Morgan, P., Sangaralingham, S., Lowe, A., Vondra, P., Jamadarkhana, S., Cruz, C., Bhandary, R., Hersey, P., Furneval, J., Inne, R., Doble, P., Attwood, B., Parson, P., Page, V., Zhao, X., Grecu, I., Dalton, J., Hegazy, M., Awad, Y., Naylor, D., Naylor, A., Lee, S., Brevard, and S., Davis

Subjects
Infection risk, Male, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, Antibiotic resistance, Tracte gastrointestinal - Malalties, Definitions, Critical Care and Intensive Care Medicine, THERAPY, DEFINITIONS, Infections::Intraabdominal Infections [DISEASES], 0302 clinical medicine, Intensive care, Intra-abdominal infection, Mortality, Multidrug resistance, Peritonitis, Sepsis, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Observational study, Septic shock, ComputingMilieux_MISCELLANEOUS, Critical Illness/epidemiology, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, Intraabdominal Infections/epidemiology, Abdominal infection, Multicenter study, 3. Good health, Management, Clinical trial, Cohort, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Cohort analysis, Community acquired infection, Cohort study, Human, medicine.medical_specialty, Carbapenem resistance, Critical Illness, Peritoneal dialysis, Vancomycin resistant enterococcus, Major clinical study, Article, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Settore MED/41 - ANESTESIOLOGIA, Humans, Critical care medicine, Hospital infection, Aged, Science & Technology, Liver failure, Antibiotic therapy, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Epidemiologic Studies, 030228 respiratory system, Intensive Care Unit, Sepsis (Diptera), Septic Shock, Risk factor, Human medicine, General & internal medicine, Congestive heart failure, Original, Cohort Studies, Risk Factors, Cause of Death, Epidemiology, Prevalence, Medicine and Health Sciences, Abdominal abscess, Sepsis/epidemiology, Middle aged, Antifungal therapy, 2. Zero hunger, Peritoniti, Antibiotic agent, Biliary tract infection, Middle Aged, infecciones bacterianas y micosis::infección::infecciones intraabdominales [ENFERMEDADES], PREVALENCE, Infections::Sepsis [DISEASES], técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Methicillin resistant staphylococcus aureus, Raonament basat en casos, Female, Critically ill patient, Life Sciences & Biomedicine, Antifungal agent, Adult, Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Predictive value, infecciones bacterianas y micosis::infección::sepsis [ENFERMEDADES], NO, Critical Care Medicine, Internal medicine, General & Internal Medicine, medicine, MANAGEMENT, Journal Article, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Septicèmia, business.industry, Pancreas disease, Malnutrition, 030208 emergency & critical care medicine, Typhlitis, Toxic megacolon, Intraabdominal Infections, Therapy, Late onset disorder, business
Abstract

Pardo-Oviedo, Juan Mauricio/0000-0003-0084-3449; Lopez-Delgado, Juan Carlos/0000-0003-3324-1129; Corradi, Francesco/0000-0002-5588-2608; De Backer, Daniel/0000-0001-9841-5762; POTA, VINCENZO/0000-0001-9999-3388; Tomescu, Dana/0000-0001-9673-5754; Sabetian, Golnar/0000-0001-8764-2150; Girardis, Massimo/0000-0002-2453-0829; Brazzi, Luca/0000-0001-7059-0622; Leone, Marc/0000-0002-3097-758X; Zabolotskikh, Igor Borisovich/0000-0002-3623-2546; De Lange, Dylan/0000-0002-0191-7270; ALMEKHLAFI, GHALEB A./0000-0002-0323-7025; Elke, Gunnar/0000-0002-4948-1605; Grigoras, Ioana/0000-0001-9412-9574; Czuczwar, Miroslaw/0000-0002-9025-6717; Nora, David/0000-0002-1133-7368; Masjedi, Mansoor/0000-0001-6175-9289; Gunst, Jan/0000-0003-2470-6393; Vidal-Cortes, Pablo/0000-0003-0225-9975; Szakmany, Tamas/0000-0003-3632-8844; Dimopoulos, George/0000-0002-3784-3103; Rello, Jordi/0000-0003-0676-6210; U nal, Necmettin/0000-0002-9440-7893; Tiberio, Iolanda FLC/0000-0002-5662-7895; Cortegiani, Andrea/0000-0003-1416-9993; Morton, Ben/0000-0002-6164-2854; Labeau, Sonia/0000-0003-3863-612X; Velickovic, Dejan/0000-0002-7312-2880; Paul, John/0000-0002-9307-3465; Pereira, Rui/0000-0002-3010-8384; Silversides, Jon/0000-0002-9562-5462; Paiva, Jose-Artur/0000-0003-4323-0220; Smuszkiewicz, Piotr/0000-0003-3067-8229; Paul, Cherish/0000-0001-6133-0036; Santos, Lurdes/0000-0002-0622-6823; PANTAZOPOULOS, IOANNIS/0000-0002-8846-519X; Ostermann, Marlies/0000-0001-9500-9080; Blot, Stijn/0000-0003-2145-0345; Naylor, Amanda/0000-0002-6431-0230; Shyamsundar, Murali/0000-0003-3797-8080; Aldecoa, Cesar/0000-0001-8789-5959; Summers, Charlotte/0000-0002-7269-2873; biskup, ewelina/0000-0002-9871-927X; Cornet, Alexander/0000-0002-9917-5251; Trenado Alvarez, Jose/0000-0002-2930-0766; Volta, Carlo/0000-0003-3533-6121; Gritsan, Alexey/0000-0002-0500-2887; Urkmez, Seval/0000-0002-3412-4226 WOS:000493268200001 PubMed ID: 31664501 PurposeTo describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock).MethodsWe performed a multicenter (n=309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis.ResultsThe cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation.ConclusionThis multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection. Pfizer investigator-initiated research grant AbSeS is a Trials Group Study of the European Society of Intensive Care Medicine. The study was supported by a Pfizer investigator-initiated research grant.

Published
2019

26. Sensitivity of the Cherenkov Telescope Array to a dark matter signal from the Galactic centre

Author

Abdalla, H., Abe, H., Abe, S., Abusleme, A., Acero, F., Acharyya, A., Acín Portella, V., Ackley, K., Adam, R., Adams, C., Adhikari, S. S., Aguado-Ruesga, I., Agudo, I., Aguilera, R., Aguirre-Santaella, A., Aharonian, F., Alberdi, A., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Alves Batista, R., Amans, J. -P, Amati, L., Amato, E., Ambrogi, L., Ambrosi, G., Ambrosio, M., Ammendola, R., Anderson, J., Anduze, M., Angüner, E. O., Antonelli, L. A., Antonuccio, V., Antoranz, P., Anutarawiramkul, R., Aragunde Gutierrez, J., Aramo, C., Araudo, A., Araya, M., Arbet-Engels, A., Arcaro, C., Arendt, V., Armand, C., Armstrong, T., Arqueros, F., Arrabito, L., Arsioli, B., Artero, M., Asano, K., Ascasíbar, Y., Aschersleben, J., Ashley, M., Attinà, P., Aubert, P., Singh, C. B., Baack, D., Babic, A., Backes, M., Baena, V., Bajtlik, S., Baktash, A., Balazs, C., Balbo, M., Ballester, O., Ballet, J., Balmaverde, B., Bamba, A., Bandiera, R., Baquero Larriva, A., Barai, P., Barbier, C., Barbosa Martins, V., Barcelo, M., Barkov, M., Barnard, M., Baroncelli, L., Barres Almeida, U., Barrio, J. A., Bastieri, D., Batista, P. I., Batkovic, I., Bauer, C., Bautista-González, R., Baxter, J., Becciani, U., Becerra González, J., Becherini, Y., Beck, G., Becker Tjus, J., Bednarek, W., Belfiore, A., Bellizzi, L., Belmont, R., Benbow, W., Berge, D., Bernardini, E., Bernardos, M. I., Bernlöhr, K., Berti, A., Berton, M., Bertucci, B., Beshley, V., Bhatt, N., Bhattacharyya, S., Bhattacharyya, W., Bi, B., Bicknell, G., Biederbeck, N., Bigongiari, C., Biland, A., Bird, R., Bissaldi, E., Biteau, J., Bitossi, M., Blanch, O., Blank, M., Blazek, J., Bobin, J., Boccato, C., Bocchino, F., Boehm, C., Bohacova, M., Boisson, C., Boix, J., Bolle, J. -P, Bolmont, J., Bonanno, G., Bonavolontà, C., Bonneau Arbeletche, L., Bonnoli, G., Bordas, P., Borkowski, J., Bórquez, S., Bose, R., Bose, D., Bosnjak, Z., Bottacini, E., Böttcher, M., Botticella, M. T., Boutonnet, C., Bouyjou, F., Bozhilov, V., Bozzo, E., Brahimi, L., Braiding, C., Brau-Nogué, S., Breen, S., Bregeon, J., Breuhaus, M., Brill, A., Brisken, W., Brocato, E., Brown, A. M., Brügge, K., Brun, P., Brun, F., Brunetti, L., Brunetti, G., Bruno, P., Bruno, A., Bruzzese, A., Bucciantini, N., Buckley, J., Bühler, R., Bulgarelli, A., Bulik, T., Bünning, M., Bunse, M., Burton, M., Burtovoi, A., Buscemi, M., Buschjäger, S., Busetto, G., Buss, J., Byrum, K., Caccianiga, A., Cadoux, F., Calanducci, A., Calderón, C., Calvo Tovar, J., Cameron, R., Campaña, P., Canestrari, R., Cangemi, F., Cantlay, B., Capalbi, M., Capasso, M., Cappi, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Cárdenas, V., Cardiel, L., Cardillo, M., Carlile, C., Caroff, S., Carosi, R., Carosi, A., Carquín, E., Carrère, M., Casandjian, J. -M, Casanova, S., Cascone, E., Cassol, F., Castro-Tirado, A. J., Catalani, F., Catalano, O., Cauz, D., Ceccanti, A., Celestino Silva, C., Celli, S., Cerny, K., Cerruti, M., Chabanne, E., Chadwick, P., Chai, Y., Chambery, P., Champion, C., Chandra, S., Chaty, S., Chen, A., Cheng, K., Chernyakova, M., Chiaro, G., Chiavassa, A., Chikawa, M., Chitnis, V. R., Chudoba, J., Chytka, L., Cikota, S., Circiello, A., Clark, P., Çolak, M., Colombo, E., Colome, J., Colonges, S., Comastri, A., Compagnino, A., Conforti, V., Congiu, E., Coniglione, R., Conrad, J., Conte, F., Contreras, J. L., Coppi, P., Cornat, R., Coronado-Blazquez, J., Cortina, J., Costa, A., Costantini, H., Cotter, G., Courty, B., Covino, S., Crestan, S., Cristofari, P., Crocker, R., Croston, J., Cubuk, K., Cuevas, O., Cui, X., Cusumano, G., Cutini, S., D’aì, A., D’amico, G., D’ammando, F., D’avanzo, P., Da Vela, P., Dadina, M., Dai, S., Dalchenko, M., Dall’ Ora, M., Daniel, M. K., Dauguet, J., Davids, I., Davies, J., Dawson, B., Angelis, A., Araújo Carvalho, A. E., Bony Lavergne, M., Caprio, V., Cesare, G., Frondat, F., Gouveia Dal Pino, E. M., La Calle, I., Lotto, B., Luca, A., Martino, D., Menezes, R. M., Naurois, M., Oña Wilhelmi, E., Palma, F., Persio, F., Simone, N., Souza, V., Del Santo, M., Del Valle, M. V., Delagnes, E., Deleglise, G., Delfino Reznicek, M., Delgado, C., Delgado Giler, A. G., Delgado Mengual, J., Della Ceca, R., Della Valle, M., Della Volpe, D., Depaoli, D., Depouez, D., Devin, J., Di Girolamo, T., Di Giulio, C., Di Piano, A., Di Pierro, F., Di Venere, L., Díaz, C., Díaz-Bahamondes, C., Dib, C., Diebold, S., Digel, S., Dima, R., Djannati-Ataï, A., Djuvsland, J., Dmytriiev, A., Docher, K., Domínguez, A., Dominis Prester, D., Donath, A., Donini, A., Dorner, D., Doro, M., Dos Anjos, R. D. C., Dournaux, J. -L, Downes, T., Drake, G., Drass, H., Dravins, D., Duangchan, C., Duara, A., Dubus, G., Ducci, L., Duffy, C., Dumora, D., Dundas Morå, K., Durkalec, A., Dwarkadas, V. V., Ebr, J., Eckner, C., Eder, J., Ederoclite, A., Edy, E., Egberts, K., Einecke, S., Eisch, J., Eleftheriadis, C., Elsässer, D., Emery, G., Emmanoulopoulos, D., Ernenwein, J. -P, Errando, M., Escarate, P., Escudero, J., Espinoza, C., Ettori, S., Eungwanichayapant, A., Evans, P., Evoli, C., Fairbairn, M., Falceta-Goncalves, D., Falcone, A., Fallah Ramazani, V., Falomo, R., Farakos, K., Fasola, G., Fattorini, A., Favre, Y., Fedora, R., Fedorova, E., Fegan, S., Feijen, K., Feng, Q., Ferrand, G., Ferrara, G., Ferreira, O., Fesquet, M., Fiandrini, E., Fiasson, A., Filipovic, M., Fink, D., Finley, J. P., Fioretti, V., Fiorillo, D. F. G., Fiorini, M., Flis, S., Flores, H., Foffano, L., Föhr, C., Fonseca, M. V., Font, L., Fontaine, G., Fornieri, O., Fortin, P., Fortson, L., Fouque, N., Fournier, A., Fraga, B., Franceschini, A., Franco, F. J., Franco Ordovas, A., Freixas Coromina, L., Fresnillo, L., Fruck, C., Fugazza, D., Fujikawa, Y., Fujita, Y., Fukami, S., Fukazawa, Y., Fukui, Y., Fulla, D., Funk, S., Furniss, A., Gabella, O., Gabici, S., Gaggero, D., Galanti, G., Galaz, G., Galdemard, P., Gallant, Y., Galloway, D., Gallozzi, S., Gammaldi, V., Garcia, R., Garcia, E., García, E., Garcia López, R., Garczarczyk, M., Gargano, F., Gargano, C., Garozzo, S., Gascon, D., Gasparetto, T., Gasparrini, D., Gasparyan, H., Gaug, M., Geffroy, N., Gent, A., Germani, S., Gesa, L., Ghalumyan, A., Ghedina, A., Ghirlanda, G., Gianotti, F., Giarrusso, S., Giarrusso, M., Giavitto, G., Giebels, B., Giglietto, N., Gika, V., Gillardo, F., Gimenes, R., Giordano, F., Giovannini, G., Giro, E., Giroletti, M., Giuliani, A., Giunti, L., Gjaja, M., Glicenstein, J. -F, Gliwny, P., Godinovic, N., Göksu, H., Goldoni, P., Gómez, J. L., Gómez-Vargas, G., González, M. M., González, J. M., Gothe, K. S., Götz, D., Goulart Coelho, J., Gourgouliatos, K., Grabarczyk, T., Graciani, R., Grandi, P., Grasseau, G., Grasso, D., Green, A. J., Green, D., Green, J., Greenshaw, T., Grenier, I., Grespan, P., Grillo, A., Grondin, M. -H, Grube, J., Guarino, V., Guest, B., Gueta, O., Gündüz, M., Gunji, S., Gusdorf, A., Gyuk, G., Hackfeld, J., Hadasch, D., Haga, J., Hagge, L., Hahn, A., Hajlaoui, J. E., Hakobyan, H., Halim, A., Hamal, P., Hanlon, W., Hara, S., Harada, Y., Hardcastle, M. J., Harvey, M., Hashiyama, K., Hassan Collado, T., Haubold, T., Haupt, A., Hautmann, U. A., Havelka, M., Hayashi, K., Hayashida, M., He, H., Heckmann, L., Heller, M., Helo, J. C., Henault, F., Henri, G., Hermann, G., Hermel, R., Hernández Cadena, S., Herrera Llorente, J., Herrero, A., Hervet, O., Hinton, J., Hiramatsu, A., Hiroshima, N., Hirotani, K., Hnatyk, B., Hnatyk, R., Hoang, J. K., Hoffmann, D., Hofmann, W., Hoischen, C., Holder, J., Holler, M., Hona, B., Horan, D., Hörandel, J., Horns, D., Horvath, P., Houles, J., Hovatta, T., Hrabovsky, M., Hrupec, D., Huang, Y., Huet, J. -M, Hughes, G., Hui, D., Hull, G., Humensky, T. B., Hütten, M., Iaria, R., Iarlori, M., Illa, J. M., Imazawa, R., Impiombato, D., Inada, T., Incardona, F., Ingallinera, A., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Insolia, A., Iocco, F., Ioka, K., Ionica, M., Iori, M., Iovenitti, S., Iriarte, A., Ishio, K., Ishizaki, W., Iwamura, Y., Jablonski, C., Jacquemier, J., Jacquemont, M., Jamrozy, M., Janecek, P., Jankowsky, F., Jardin-Blicq, A., Jarnot, C., Jean, P., Jiménez Martínez, I., Jin, W., Jocou, L., Jordana, N., Josselin, M., Jouvin, L., Jung-Richardt, I., Junqueira, F. J. P. A., Juramy-Gilles, C., Jurysek, J., Kaaret, P., Kadowaki, L. H. S., Kagaya, M., Kalekin, O., Kankanyan, R., Kantzas, D., Karas, V., Karastergiou, A., Karkar, S., Kasai, E., Kasperek, J., Katagiri, H., Kataoka, J., Katarzyński, K., Katsuda, S., Katz, U., Kawanaka, N., Kazanas, D., Kerszberg, D., Khélifi, B., Kherlakian, M. C., Kian, T. P., Kieda, D. B., Kihm, T., Kim, S., Kimeswenger, S., Kisaka, S., Kissmann, R., Kleijwegt, R., Kleiner, T., Kluge, G., Kluźniak, W., Knapp, J., Knödlseder, J., Kobakhidze, A., Kobayashi, Y., Koch, B., Kocot, J., Kohri, K., Kokkotas, K., Komin, N., Kong, A., Kosack, K., Kowal, G., Krack, F., Krause, M., Krennrich, F., Krumholz, M., Kubo, H., Kudryavtsev, V., Kunwar, S., Kuroda, Y., Kushida, J., Kushwaha, P., La Barbera, A., La Palombara, N., La Parola, V., La Rosa, G., Lahmann, R., Lamanna, G., Lamastra, A., Landoni, M., Landriu, D., Lang, R. G., Lapington, J., Laporte, P., Lason, P., Lasuik, J., Lazendic-Galloway, J., Le Flour, T., Le Sidaner, P., Leach, S., Leckngam, A., Lee, S. -H, Lee, W. H., Lee, S., Leigui Oliveira, M. A., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P, Leone, F., Leray, V., Leto, G., Leuschner, F., Levy, C., Lindemann, R., Lindfors, E., Linhoff, L., Liodakis, I., Lipniacka, A., Lloyd, S., Lobo, M., Lohse, T., Lombardi, S., Longo, F., Lopez, A., López, M., López-Coto, R., Loporchio, S., Louis, F., Louys, M., Lucarelli, F., Lucchesi, D., Ludwig Boudi, H., Luque-Escamilla, P. L., Lyard, E., Maccarone, M. C., Maccarone, T., Mach, E., Maciejewski, A. J., Mackey, J., Madejski, G. M., Maeght, P., Maggio, C., Maier, G., Majczyna, A., Majumdar, P., Makariev, M., Mallamaci, M., Malta Nunes Almeida, R., Maltezos, S., Malyshev, D., Mandat, D., Maneva, G., Manganaro, M., Manicò, G., Manigot, P., Mannheim, K., Maragos, N., Marano, D., Marconi, M., Marcowith, A., Marculewicz, M., Marčun, B., Marín, J., Marinello, N., Marinos, P., Mariotti, M., Markoff, S., Marquez, P., Marsella, G., Martí, J., Martin, J. -M, Martin, P., Martinez, O., Martínez, M., Martínez, G., Martínez, O., Martínez-Huerta, H., Marty, C., Marx, R., Masetti, N., Massimino, P., Mastichiadis, A., Matsumoto, H., Matthews, N., Maurin, G., Max-Moerbeck, W., Maxted, N., Mazin, D., Mazziotta, M. N., Mazzola, S. M., Mbarubucyeye, J. D., Mc Comb, L., Mchardy, I., Mckeague, S., Mcmuldroch, S., Medina, E., Medina Miranda, D., Melandri, A., Melioli, C., Melkumyan, D., Menchiari, S., Mender, S., Mereghetti, S., Merino Arévalo, G., Mestre, E., Meunier, J. -L, Meures, T., Meyer, M., Micanovic, S., Miceli, M., Michailidis, M., Michałowski, J., Miener, T., Mievre, I., Miller, J., Minaya, I. A., Mineo, T., Minev, M., Miranda, J. M., Mirzoyan, R., Mitchell, A., Mizuno, T., Mode, B., Moderski, R., Mohrmann, L., Molina, E., Molinari, E., Teresa Montaruli, Monteiro, I., Moore, C., Moralejo, A., Morcuende-Parrilla, D., Moretti, E., Morganti, L., Mori, K., Moriarty, P., Morik, K., Morlino, G., Morris, P., Morselli, A., Mosshammer, K., Moya, P., Mukherjee, R., Muller, J., Mundell, C., Mundet, J., Murach, T., Muraczewski, A., Muraishi, H., Murase, K., Musella, I., Musumarra, A., Nagai, A., Nagar, N., Nagataki, S., Naito, T., Nakamori, T., Nakashima, K., Nakayama, K., Nakhjiri, N., Naletto, G., Naumann, D., Nava, L., Navarro, R., Nawaz, M. A., Ndiyavala, H., Neise, D., Nellen, L., Nemmen, R., Newbold, M., Neyroud, N., Ngernphat, K., Nguyen Trung, T., Nicastro, L., Nickel, L., Niemiec, J., Nieto, D., Nievas, M., Nigro, C., Nikołajuk, M., Ninci, D., Nishijima, K., Noda, K., Nogami, Y., Nolan, S., Nomura, R., Norris, R., Nosek, D., Nöthe, M., Novosyadlyj, B., Novotny, V., Nozaki, S., Nunio, F., O’brien, P., Obara, K., Oger, R., Ohira, Y., Ohishi, M., Ohm, S., Ohtani, Y., Oka, T., Okazaki, N., Okumura, A., Olive, J. -F, Oliver, C., Olivera, G., Olmi, B., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, S., Orlando, E., Osborne, J. P., Ostrowski, M., Otte, N., Ovcharov, E., Owen, E., Oya, I., Ozieblo, A., Padovani, M., Pagano, I., Pagliaro, A., Paizis, A., Palatiello, M., Palatka, M., Palazzi, E., Panazol, J. -L, Paneque, D., Panes, B., Panny, S., Pantaleo, F. R., Panter, M., Paoletti, R., Paolillo, M., Papitto, A., Paravac, A., Paredes, J. M., Pareschi, G., Park, N., Parmiggiani, N., Parsons, R. D., Paśko, P., Patel, S., Patricelli, B., Pauletta, G., Pavletić, L., Pavy, S., Pe’er, A., Pech, M., Pecimotika, M., Pellegriti, M. G., Peñil Del Campo, P., Penno, M., Pepato, A., Perard, S., Perennes, C., Peres, G., Peresano, M., Pérez-Aguilera, A., Pérez-Romero, J., Pérez-Torres, M. A., Perri, M., Persic, M., Petrera, S., Petrucci, P. -O, Petruk, O., Peyaud, B., Pfrang, K., Pian, E., Piano, G., Piatteli, P., Pietropaolo, E., Pillera, R., Pilszyk, B., Pimentel, D., Pintore, F., Pio García, C., Pirola, G., Piron, F., Pisarski, A., Pita, S., Pohl, M., Poireau, V., Poledrelli, P., Pollo, A., Polo, M., Pongkitivanichkul, C., Porthault, J., Powell, J., Pozo, D., Prado, R. R., Prandini, E., Prasit, P., Prast, J., Pressard, K., Principe, G., Priyadarshi, C., Produit, N., Prokhorov, D., Prokoph, H., Prouza, M., Przybilski, H., Pueschel, E., Pühlhofer, G., Puljak, I., Pumo, M. L., Punch, M., Queiroz, F., Quinn, J., Quirrenbach, A., Rainò, S., Rajda, P. J., Rando, R., Razzaque, S., Rebert, E., Recchia, S., Reichherzer, P., Reimer, O., Reimer, A., Reisenegger, A., Remy, Q., Renaud, M., Reposeur, T., Reville, B., Reymond, J. -M, Reynolds, J., Rhode, W., Ribeiro, D., Ribó, M., Richards, G., Richtler, T., Rico, J., Rieger, F., Riitano, L., Ripepi, V., Riquelme, M., Riquelme, D., Rivoire, S., Rizi, V., Roache, E., Röben, B., Roche, M., Rodriguez, J., Rodriguez Fernandez, G., Rodriguez Ramirez, J. C., Rodríguez Vázquez, J. J., Roepke, F., Rojas, G., Romanato, L., Romano, P., Romeo, G., Romero Lobato, F., Romoli, C., Roncadelli, M., Ronda, S., Rosado, J., Rosales Leon, A., Rowell, G., Rudak, B., Rugliancich, A., Ruíz Del Mazo, J. E., Rujopakarn, W., Rulten, C., Russell, C., Russo, F., Sadeh, I., Sæther Hatlen, E., Safi-Harb, S., Saha, L., Saha, P., Sahakian, V., Sailer, S., Saito, T., Sakaki, N., Sakurai, S., Salesa Greus, F., Salina, G., Salzmann, H., Sanchez, D., Sánchez-Conde, M., Sandaker, H., Sandoval, A., Sangiorgi, P., Sanguillon, M., Sano, H., Santander, M., Santangelo, A., Santos, E. M., Santos-Lima, R., Sanuy, A., Sapozhnikov, L., Saric, T., Sarkar, S., Sasaki, H., Sasaki, N., Satalecka, K., Sato, Y., Saturni, F. G., Sawada, M., Sawangwit, U., Schaefer, J., Scherer, A., Scherpenberg, J., Schipani, P., Schleicher, B., Schmoll, J., Schneider, M., Schoorlemmer, H., Schovanek, P., Schussler, F., Schwab, B., Schwanke, U., Schwarz, J., Schweizer, T., Sciacca, E., Scuderi, S., Seglar Arroyo, M., Segreto, A., Seitenzahl, I., Semikoz, D., Sergijenko, O., Serna Franco, J. E., Servillat, M., Seweryn, K., Sguera, V., Shalchi, A., Shang, R. Y., Sharma, P., Shellard, R. 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C., Terrier, R., Terzic, T., Teshima, M., Testa, V., Thibaut, D., Thocquenne, F., Tian, W., Tibaldo, L., Tiengo, A., Tiziani, D., Tluczykont, M., Todero Peixoto, C. J., Tokanai, F., Toma, K., Tomankova, L., Tomastik, J., Tonev, D., Tornikoski, M., Torres, D. F., Torresi, E., Tosti, G., Tosti, L., Totani, T., Tothill, N., Toussenel, F., Tovmassian, G., Travnicek, P., Trichard, C., Trifoglio, M., Trois, A., Truzzi, S., Tsiahina, A., Tsuru, T., Turk, B., Tutone, A., Uchiyama, Y., Umana, G., Utayarat, P., Vaclavek, L., Vacula, M., Vagelli, V., Vagnetti, F., Vakili, F., Valdivia, J. A., Valentino, M., Valio, A., Vallage, B., Vallania, P., Valverde Quispe, J. V., Den Berg, A. M., Driel, W., Eldik, C., Rensburg, C., Soelen, B., Vandenbroucke, J., Vanderwalt, J., Vasileiadis, G., Vassiliev, V., Vázquez Acosta, M., Vecchi, M., Vega, A., Veh, J., Veitch, P., Venault, P., Venter, C., Ventura, S., Vercellone, S., Vergani, S., Verguilov, V., Verna, G., Vernetto, S., Verzi, V., Vettolani, G. P., Veyssiere, C., Viale, I., Viana, A., Viaux, N., Vicha, J., Vignatti, J., Vigorito, C. F., Villanueva, J., Vink, J., Vitale, V., Vittorini, V., Vodeb, V., Voelk, H., Vogel, N., Voisin, V., Vorobiov, S., Vovk, I., Vrastil, M., Vuillaume, T., Wagner, S. J., Wagner, R., Wagner, P., Wakazono, K., Wakely, S. P., Walter, R., Ward, M., Warren, D., Watson, J., Webb, N., Wechakama, M., Wegner, P., Weinstein, A., Weniger, C., Werner, F., Wetteskind, H., White, M., White, R., Wierzcholska, A., Wiesand, S., Wijers, R., Wilkinson, M., Will, M., Williams, D. A., Williams, J., Williamson, T., Wolter, A., Wong, Y. W., Wood, M., Wunderlich, C., Yamamoto, T., Yamamoto, H., Yamane, Y., Yamazaki, R., Yanagita, S., Yang, L., Yoo, S., Yoshida, T., Yoshikoshi, T., Yu, P., Yusafzai, A., Zacharias, M., Zaharijas, G., Zaldivar, B., Zampieri, L., Zanmar Sanchez, R., Zaric, D., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zenin, A., Zerwekh, A., Zhdanov, V. 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CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CTA, Durham University, Institut Polytechnique de Paris, Columbia University, Instituto de Astrofísica de Andalucía-CSIC, Universidad Autónoma de Madrid, Universidad Nacional Autónoma de México, Pontificia Universidad Católica de Chile, Département de Physique Nucléaire et Corpusculaire, Gran Sasso Science Institute, Universidade de São Paulo (USP), INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna, Università degli Studi di Perugia, CPPM, INAF - Osservatorio Astronomico di Roma, INFN Sezione di Napoli, Czech Academy of Sciences, Universidad Complutense de Madrid, University of New South Wales, Barcelona Institute of Science and Technology, Deutsches Elektronen-Synchrotron, Institute of Physical and Chemical Research, Centro Brasileiro de Pesquisas Físicas, Università degli Studi di Padova, Universidad de La Laguna, University of the Witwatersrand, Ruhr-Universität Bochum, Center for Astrophysics - Harvard and Smithsonian, Universidade Estadual Paulista (Unesp), Max-Planck-Institut für Kernphysik, INFN Sezione di Torino, Pidstryhach Institute for Applied Problems in Mechanics and Mathematics NASU, Université de Paris, Institute for Particle Physics, INFN Sezione di Bari and Politecnico di Bari, INAF - Osservatorio Astronomico di Palermo 'G.S. Vaiana', PSL University, IEEC-UB, Sofia University, IN2P3, Université Paris-Saclay, INAF - Osservatorio Astrofisico di Catania, College Hill, INAF - Osservatorio Astronomico di Padova, INFN Sezione di Catania, Stanford University, Núcleo de Astrofísica Teórica (NAT/UCS), INAF - Istituto di Astrofisica Spaziale e Fisica Cosmica di Milano, INFN Sezione di Pisa, Polish Academy of Sciences, INAF - Osservatorio Astronomico di Capodimonte, Università degli Studi di Udine, Sorbonne Paris Cité, DAp, Dublin City University, Universitá degli Studi di Torino, Denys Wilkinson Building, INAF - Istituto di Astrofisica Spaziale e Fisica Cosmica di Palermo, INAF - Istituto di Radioastronomia, Cherenkov Telescope Array Observatory, Universidade Federal do Paraná (UFPR), Institució Catalana de Recerca I Estudis Avançats (ICREA), CIEMAT, Complesso Universitario di Monte Sant'Angelo, INFN Sezione di Bari, Universität Tübingen, University of Nova Gorica, TU Dortmund University, Astronomical Observatory of Taras Shevchenko National University of Kyiv, Western Sydney University, Nagoya University, Yerevan Physics Institute, Università degli Studi di Bari, Astroparticule et Cosmologie, Open University of Israel, Yamagata University, University of Delaware, Radboud University Nijmegen, RCPTM, University of Turku, Josip Juraj Strossmayer University of Osijek, Max-Planck-Institut für Physik, INFN Sezione di Roma La Sapienza, Jagiellonian University, Gallalee Hall, Nicolaus Copernicus University, Thessaloniki, Leopold-Franzens-Universität, Université Paul Sabatier, KEK (High Energy Accelerator Research Organization), Kyoto University, Tokai University, University of Leicester, Universidade Federal do ABC (UFABC), LPNHE, Humboldt University Berlin, Università degli Studi di Trieste, Universidad de Jaén, Universitat Autònoma de Barcelona, Edifici C3, Faculty of Physics, University of Amsterdam, Erlangen Centre for Astroparticle Physics (ECAP), Bulgarian Academy of Sciences, Hiroshima University, Madison, INFN Sezione di Roma Tor Vergata, University of Bath, Institute of Particle and Nuclear Physics, University of California, Tokushima University, INAF - Osservatorio Astronomico di Brera, INAF - Istituto di Astrofisica e Planetologia Spaziali (IAPS), Universität Potsdam, Federal University of Rio Grande do Norte, Zentrum für Astronomie der Universität Heidelberg, University of Johannesburg, Universidad de Concepción, Universidade Federal de São Carlos (UFSCar), Dept of Physics and Astronomy, National Astronomical Research Institute of Thailand, Academic Computer Centre CYFRONET AGH, University of Geneva, Universität Zürich, INAF - Osservatorio Astrofisico di Torino, University of Hawai'i at Manoa, KVI - Center for Advanced Radiation Technology, Sezione di Fisica, Santa Cruz, Ibaraki University, FESB, Universidad Metropolitana de Ciencias de la Educación, Georgia Institute of Technology, AlbaNova, Sun Yat-sen University, Agenzia Spaziale Italiana (ASI), Acharyya, A., Adam, R., Adams, C., Agudo, I., Aguirre-Santaella, A., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Alves Batista, R., Amati, L., Ambrosi, G., Ang??ner, E. O., Antonelli, L. A., Aramo, C., Araudo, A., Armstrong, T., Arqueros, F., Asano, K., Ascas??bar, Y., Ashley, M., Balazs, C., Ballester, O., Baquero Larriva, A., Barbosa Martins, V., Barkov, M., Barres de Almeida, U., Barrio, J. A., Bastieri, D., Becerra, J., Beck, G., Becker Tjus, J., Benbow, W., Benito, M., Berge, D., Bernardini, E., Bernl??hr, K., Berti, A., Bertucci, B., Beshley, V., Biasuzzi, B., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Bocchino, F., Boisson, C., Bonneau Arbeletche, L., Bordas, P., Bosnjak, Z., Bottacini, E., Bozhilov, V., Bregeon, J., Brill, A., Bringmann, T., Brown, A. M., Brun, P., Brun, F., Bruno, P., Bulgarelli, A., Burton, M., Burtovoi, A., Buscemi, M., Cameron, R., Capasso, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Carosi, R., Carosi, A., Casanova, S., Cascone, E., Cassol, F., Catalani, F., Cauz, D., Cerruti, M., Chadwick, P., Chaty, S., Chen, A., Chernyakova, M., Chiaro, G., Chiavassa, A., Chikawa, M., Chudoba, J., olak, M., Conforti, V., Coniglione, R., Conte, F., Contreras, J. L., Coronado-Blazquez, J., Costa, A., Costantini, H., Cotter, G., Cristofari, P., D'A��, A., D'Ammando, F., Damone, L. A., Daniel, M. K., Dazzi, F., De Angelis, A., De Caprio, V., de C??ssia dos Anjos, R., de Gouveia Dal Pino, E. M., De Lotto, B., De Martino, D., de O??a Wilhelmi, E., De Palma, F., de Souza, V., Delgado, C., Delgado Giler, A. G., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Pierro, F., Di Venere, L., Diebold, S., Dmytriiev, A., Dom??nguez, A., Donini, A., Doro, M., Ebr, J., Eckner, C., Edwards, T. D. P., Ekoume, T. R. N., Els??sser, D., Evoli, C., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Ferrara, G., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Foffano, L., Fontaine, G., Fornieri, O., Franco, F. J., Fukami, S., Fukui, Y., Gaggero, D., Galaz, G., Gammaldi, V., Garcia, E., Garczarczyk, M., Gascon, D., Gent, A., Ghalumyan, A., Gianotti, F., Giarrusso, M., Giavitto, G., Giglietto, N., Giordano, F., Giuliani, A., Glicenstein, J., Gnatyk, R., Goldoni, P., Gonz??lez, M. M., Gourgouliatos, K., Granot, J., Grasso, D., Green, J., Grillo, A., Gueta, O., Gunji, S., Halim, A., Hassan, T., Heller, M., Hern??ndez Cadena, S., Hiroshima, N., Hnatyk, B., Hofmann, W., Holder, J., Horan, D., H??randel, J., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Hughes, G., Humensky, T. B., H??tten, M., Iarlori, M., Inada, T., Inoue, S., Iocco, F., Iori, M., Jamrozy, M., Janecek, P., Jin, W., Jouvin, L., Jurysek, J., Karukes, E., Katarzy??ski, K., Kazanas, D., Kerszberg, D., Kherlakian, M. C., Kissmann, R., Kn??dlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kubo, H., Kushida, J., Lamanna, G., Lapington, J., Laporte, P., Leigui de Oliveira, M. A., Lenain, J., Leone, F., Leto, G., Lindfors, E., Lohse, T., Lombardi, S., Longo, F., Lopez, A., L??pez, M., L??pez-Coto, R., Loporchio, S., Luque-Escamilla, P. L., Mach, E., Maggio, C., Maier, G., Mallamaci, M., Malta Nunes de Almeida, R., Mandat, D., Manganaro, M., Mangano, S., Manic??, G., Marculewicz, M., Mariotti, M., Markoff, S., Marquez, P., Mart??, J., Martinez, O., Mart??nez, M., Mart??nez, G., Mart??nez-Huerta, H., Maurin, G., Mazin, D., Mbarubucyeye, J. D., Medina Miranda, D., Meyer, M., Miceli, M., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Mizuno, T., Mode, B., Moderski, R., Mohrmann, L., Molina, E., Montaruli, T., Moralejo, A., Morcuende-Parrilla, D., Morselli, A., Mukherjee, R., Mundell, C., Nagai, A., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Niko??ajuk, M., Ninci, D., Noda, K., Nosek, D., Nozaki, S., Ohira, Y., Ohishi, M., Ohtani, Y., Oka, T., Okumura, A., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, S., Orlando, E., Ostrowski, M., Oya, I., Pagano, I., Pagliaro, A., Palatiello, M., Pantaleo, F. R., Paredes, J. M., Pareschi, G., Parmiggiani, N., Patricelli, B., Pavleti??, L., Pe'Er, A., Pecimotika, M., P??rez-Romero, J., Persic, M., Petruk, O., Pfrang, K., Piano, G., Piatteli, P., Pietropaolo, E., Pillera, R., Pilszyk, B., Pintore, F., Pohl, M., Poireau, V., Prado, R. R., Prandini, E., Prast, J., Principe, G., Prokoph, H., Prouza, M., Przybilski, H., P??hlhofer, G., Pumo, M. L., Queiroz, F., Quirrenbach, A., Rain??, S., Rando, R., Razzaque, S., Recchia, S., Reimer, O., Reisenegger, A., Renier, Y., Rhode, W., Ribeiro, D., Rib??, M., Richtler, T., Rico, J., Rieger, F., Rinchiuso, L., Rizi, V., Rodriguez, J., Rodriguez Fernandez, G., Rodriguez Ramirez, J. C., Rojas, G., Romano, P., Romeo, G., Rosado, J., Rowell, G., Rudak, B., Russo, F., Sadeh, I., S??ther Hatlen, E., Safi-Harb, S., Salesa Greus, F., Salina, G., Sanchez, D., S??nchez-Conde, M., Sangiorgi, P., Sano, H., Santander, M., Santos, E. M., Santos-Lima, R., Sanuy, A., Sarkar, S., Saturni, F. G., Sawangwit, U., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Seglar-Arroyo, M., Sergijenko, O., Servillat, M., Seweryn, K., Shalchi, A., Sharma, P., Shellard, R. C., Siejkowski, H., Silk, J., Siqueira, C., Sliusar, V., S??owikowska, A., Sokolenko, A., Sol, H., Spencer, S., Stamerra, A., Stani??, S., Starling, R., Stolarczyk, T., Straumann, U., Stri??kovi??, J., Suda, Y., Suomijarvi, T., wierk, P., Tavecchio, F., Taylor, L., Tejedor, L. A., Teshima, M., Testa, V., Tibaldo, L., Todero Peixoto, C. J., Tokanai, F., Tonev, D., Tosti, G., Tosti, L., Tothill, N., Truzzi, S., Travnicek, P., Vagelli, V., Vallage, B., Vallania, P., van Eldik, C., Vandenbroucke, J., Varner, G. S., Vassiliev, V., V??zquez Acosta, M., Vecchi, M., Ventura, S., Vercellone, S., Vergani, S., Verna, G., Viana, A., Vigorito, C. F., Vink, J., Vitale, V., Vorobiov, S., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., Watson, J., Weniger, C., White, R., White, M., Wiemann, R., Wierzcholska, A., Will, M., Williams, D. A., Wischnewski, R., Yanagita, S., Yang, L., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zakaria, A. A., Zampieri, L., Zanin, R., Zaric, D., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zhdanov, V. I., ivec, M., ITA, USA, GBR, FRA, DEU, ESP, AUT, BEL, BRA, HRV, DNK, JPN, IRL, NLD, POL, SVN, CHE, High Energy Astrophys. & Astropart. Phys (API, FNWI), GRAPPA (ITFA, IoP, FNWI), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Iocco, Fabio, Anguner, E. O., Ascasibar, Y., Bernlohr, K., Colak, M., D'Ai, A., de Angelis, A., de Caprio, V., de Cassia dos Anjos, R., de Lotto, B., de Martino, D., de Ona Wilhelmi, E., de Palma, F., Dominguez, A., Elsasser, D., Gonzalez, M. M., Hernandez Cadena, S., Horandel, J., Hutten, M., Katarzynski, K., Knodlseder, J., Lopez, M., Lopez-Coto, R., Manico, G., Marti, J., Martinez, M., Martinez, G., Martinez-Huerta, H., Nikolajuk, M., Pavletic, L., Perez-Romero, J., Puhlhofer, G., Raino, S., Ribo, M., Saether Hatlen, E., Sanchez-Conde, M., Slowikowska, A., Stanic, S., Striskovic, J., Swierk, P., Vazquez Acosta, M., Zivec, M., Consortium, The CTA, Acharyya A., Adam R., Adams C., Agudo I., Aguirre-Santaella A., Alfaro R., Alfaro J., Alispach C., Aloisio R., Alves Batista R., Amati L., Ambrosi G., Anguner E.O., Antonelli L.A., Aramo C., Araudo A., Armstrong T., Arqueros F., Asano K., Ascasibar Y., Ashley M., Balazs C., Ballester O., Baquero Larriva A., Barbosa Martins V., Barkov M., Barres de Almeida U., Barrio J.A., Bastieri D., Becerra J., Beck G., Becker Tjus J., Benbow W., Benito M., Berge D., Bernardini E., Bernlohr K., Berti A., Bertucci B., Beshley V., Biasuzzi B., Biland A., Bissaldi E., Biteau J., Blanch O., Blazek J., Bocchino F., Boisson C., Bonneau Arbeletche L., Bordas P., Bosnjak Z., Bottacini E., Bozhilov V., Bregeon J., Brill A., Bringmann T., Brown A.M., Brun P., Brun F., Bruno P., Bulgarelli A., Burton M., Burtovoi A., Buscemi M., Cameron R., Capasso M., Caproni A., Capuzzo-Dolcetta R., Caraveo P., Carosi R., Carosi A., Casanova S., Cascone E., Cassol F., Catalani F., Cauz D., Cerruti M., Chadwick P., Chaty S., Chen A., Chernyakova M., Chiaro G., Chiavassa A., Chikawa M., Chudoba J., Colak M., Conforti V., Coniglione R., Conte F., Contreras J.L., Coronado-Blazquez J., Costa A., Costantini H., Cotter G., Cristofari P., D'Ai A., D'Ammando F., Damone L.A., Daniel M.K., Dazzi F., de Angelis A., de Caprio V., de Cassia dos Anjos R., de Gouveia Dal Pino E.M., de Lotto B., de Martino D., de Ona Wilhelmi E., de Palma F., de Souza V., Delgado C., Delgado Giler A.G., della Volpe D., Depaoli D., Di Girolamo T., Di Pierro F., Di Venere L., Diebold S., Dmytriiev A., Dominguez A., Donini A., Doro M., Ebr J., Eckner C., Edwards T.D.P., Ekoume T.R.N., Elsasser D., Evoli C., Falceta-Goncalves D., Fedorova E., Fegan S., Feng Q., Ferrand G., Ferrara G., Fiandrini E., Fiasson A., Filipovic M., Fioretti V., Fiori M., Foffano L., Fontaine G., Fornieri O., Franco F.J., Fukami S., Fukui Y., Gaggero D., Galaz G., Gammaldi V., Garcia E., Garczarczyk M., Gascon D., Gent A., Ghalumyan A., Gianotti F., Giarrusso M., Giavitto G., Giglietto N., Giordano F., Giuliani A., Glicenstein J., Gnatyk R., Goldoni P., Gonzalez M.M., Gourgouliatos K., Granot J., Grasso D., Green J., Grillo A., Gueta O., Gunji S., Halim A., Hassan T., Heller M., Hernandez Cadena S., Hiroshima N., Hnatyk B., Hofmann W., Holder J., Horan D., Horandel J., Horvath P., Hovatta T., Hrabovsky M., Hrupec D., Hughes G., Humensky T.B., Hutten M., Iarlori M., Inada T., Inoue S., Iocco F., Iori M., Jamrozy M., Janecek P., Jin W., Jouvin L., Jurysek J., Karukes E., Katarzynski K., Kazanas D., Kerszberg D., Kherlakian M.C., Kissmann R., Knodlseder J., Kobayashi Y., Kohri K., Komin N., Kubo H., Kushida J., Lamanna G., Lapington J., Laporte P., Leigui de Oliveira M.A., Lenain J., Leone F., Leto G., Lindfors E., Lohse T., Lombardi S., Longo F., Lopez A., Lopez M., Lopez-Coto R., Loporchio S., Luque-Escamilla P.L., Mach E., Maggio C., Maier G., Mallamaci M., Malta Nunes de Almeida R., Mandat D., Manganaro M., Mangano S., Manico G., Marculewicz M., Mariotti M., Markoff S., Marquez P., Marti J., Martinez O., Martinez M., Martinez G., Martinez-Huerta H., Maurin G., Mazin D., Mbarubucyeye J.D., Medina Miranda D., Meyer M., Miceli M., Miener T., Minev M., Miranda J.M., Mirzoyan R., Mizuno T., Mode B., Moderski R., Mohrmann L., Molina E., Montaruli T., Moralejo A., Morcuende-Parrilla D., Morselli A., Mukherjee R., Mundell C., Nagai A., Nakamori T., Nemmen R., Niemiec J., Nieto D., Nikolajuk M., Ninci D., Noda K., Nosek D., Nozaki S., Ohira Y., Ohishi M., Ohtani Y., Oka T., Okumura A., Ong R.A., Orienti M., Orito R., Orlandini M., Orlando S., Orlando E., Ostrowski M., Oya I., Pagano I., Pagliaro A., Palatiello M., Pantaleo F.R., Paredes J.M., Pareschi G., Parmiggiani N., Patricelli B., Pavletic L., Pe'Er A., Pecimotika M., Perez-Romero J., Persic M., Petruk O., Pfrang K., Piano G., Piatteli P., Pietropaolo E., Pillera R., Pilszyk B., Pintore F., Pohl M., Poireau V., Prado R.R., Prandini E., Prast J., Principe G., Prokoph H., Prouza M., Przybilski H., Puhlhofer G., Pumo M.L., Queiroz F., Quirrenbach A., Raino S., Rando R., Razzaque S., Recchia S., Reimer O., Reisenegger A., Renier Y., Rhode W., Ribeiro D., Ribo M., Richtler T., Rico J., Rieger F., Rinchiuso L., Rizi V., Rodriguez J., Rodriguez Fernandez G., Rodriguez Ramirez J.C., Rojas G., Romano P., Romeo G., Rosado J., Rowell G., Rudak B., Russo F., Sadeh I., Saether Hatlen E., Safi-Harb S., Salesa Greus F., Salina G., Sanchez D., Sanchez-Conde M., Sangiorgi P., Sano H., Santander M., Santos E.M., Santos-Lima R., Sanuy A., Sarkar S., Saturni F.G., Sawangwit U., Schussler F., Schwanke U., Sciacca E., Scuderi S., Seglar-Arroyo M., Sergijenko O., Servillat M., Seweryn K., Shalchi A., Sharma P., Shellard R.C., Siejkowski H., Silk J., Siqueira C., Sliusar V., Slowikowska A., Sokolenko A., Sol H., Spencer S., Stamerra A., Stanic S., Starling R., Stolarczyk T., Straumann U., Striskovic J., Suda Y., Suomijarvi T., Swierk P., Tavecchio F., Taylor L., Tejedor L.A., Teshima M., Testa V., Tibaldo L., Todero Peixoto C.J., Tokanai F., Tonev D., Tosti G., Tosti L., Tothill N., Truzzi S., Travnicek P., Vagelli V., Vallage B., Vallania P., van Eldik C., Vandenbroucke J., Varner G.S., Vassiliev V., Vazquez Acosta M., Vecchi M., Ventura S., Vercellone S., Vergani S., Verna G., Viana A., Vigorito C.F., Vink J., Vitale V., Vorobiov S., Vovk I., Vuillaume T., Wagner S.J., Walter R., Watson J., Weniger C., White R., White M., Wiemann R., Wierzcholska A., Will M., Williams D.A., Wischnewski R., Yanagita S., Yang L., Yoshikoshi T., Zacharias M., Zaharijas G., Zakaria A.A., Zampieri L., Zanin R., Zaric D., Zavrtanik M., Zavrtanik D., Zdziarski A.A., Zech A., Zechlin H., Zhdanov V.I., and Zivec M.

Subjects
Cherenkov Telescope Array, MATÉRIA ESCURA, scale: TeV, Astronomy, atmosphere [Cherenkov counter], dark matter experiment, Dark matter theory, energy resolution, Gamma ray experiments, Particle, Astrophysics, cosmic background radiation, 01 natural sciences, 7. Clean energy, High Energy Physics - Phenomenology (hep-ph), benchmark, WIMP, HESS, energy: flux, TeV [scale], relativistic [charged particle], gamma ray experiment, MAGIC (telescope), Monte Carlo, Event reconstruction, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Contraction, spatial distribution, track data analysis, density [dark matter], Clumpy, Astrophysics::Instrumentation and Methods for Astrophysics, imaging, High Energy Physics - Phenomenology, dark matter experiments, dark matter theory, gamma ray experiments, galaxy morphology, Dark matter experiments, Física nuclear, VERITAS, Astrophysics - High Energy Astrophysical Phenomena, Simulations, noise, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, satellite, Cosmic background radiation, FOS: Physical sciences, Annihilation, dark matter: density, Astrophysics::Cosmology and Extragalactic Astrophysics, Cherenkov counter: atmosphere, heavy [dark matter], annihilation [dark matter], GLAST, Galaxy morphology, cosmic radiation [p], 0103 physical sciences, Cherenkov [radiation], Candidates, ddc:530, AGN, Cherenkov radiation, Radiative Processes, thermal [cross section], 010308 nuclear & particles physics, Física, dark matter: annihilation, Gamma-Ray Signals, dark matter, Galactic Center, TeV gamma-ray astronomy, Astronomy and Astrophysics, Mass, radiation: Cherenkov, sensitivity, MAGIC, Galaxy, Astronomía, dark matter: heavy, gamma ray, p: cosmic radiation, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], correlation, charged particle: relativistic, flux [energy], galaxy, supersymmetry, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], cross section: thermal
Abstract

Full list of authors: Acharyya, A.; Adam, R.; Adams, C.; Agudo, I.; Aguirre-Santaella, A.; Alfaro, R.; Alfaro, J.; Alispach, C.; Aloisio, R.; Alves Batista, R.; Amati, L.; Ambrosi, G.; Angüner, E. O.; Antonelli, L. A.; Aramo, C.; Araudo, A.; Armstrong, T.; Arqueros, F.; Asano, K.; Ascasíbar, Y. Ashley, M.; Balazs, C.; Ballester, O.; Baquero Larriva, A.; Barbosa Martins, V.; Barkov, M.; Barres de Almeida, U.; Barrio, J. A.; Bastieri, D.; Becerra, J.; Beck, G.; Becker Tjus, J.; Benbow, W.; Benito, M.; Berge, D.; Bernardini, E.; Bernlöhr, K.; Berti, A.; Bertucci, B.; Beshley, V.; Biasuzzi, B.; Biland, A.; Bissaldi, E.; Biteau, J.; Blanch, O.; Blazek, J.; Bocchino, F.; Boisson, C.; Bonneau Arbeletche, L.; Bordas, P.; Bosnjak, Z.; Bottacini, E.; Bozhilov, V.; Bregeon, J.; Brill, A.; Bringmann, T.; Brown, A. M.; Brun, P.; Brun, F.; Bruno, P.; Bulgarelli, A.; Burton, M.; Burtovoi, A.; Buscemi, M.; Cameron, R.; Capasso, M.; Caproni, A.; Capuzzo-Dolcetta, R.; Caraveo, P.; Carosi, R.; Carosi, A.; Casanova, S.; Cascone, E.; Cassol, F.; Catalani, F.; Cauz, D.; Cerruti, M.; Chadwick, P.; Chaty, S.; Chen, A.; Chernyakova, M.; Chiaro, G.; Chiavassa, A.; Chikawa, M.; Chudoba, J.; Çolak, M.; Conforti, V.; Coniglione, R.; Conte, F.; Contreras, J. L.; Coronado-Blazquez, J.; Costa, A.; Costantini, H.; Cotter, G.; Cristofari, P.; D'Aimath, A.; D'Ammando, F.; Damone, L. A.; Daniel, M. K.; Dazzi, F.; De Angelis, A.; De Caprio, V.; de Cássia dos Anjos, R.; de Gouveia Dal Pino, E. M.; De Lotto, B.; De Martino, D.; de Oña Wilhelmi, E.; De Palma, F.; de Souza, V.; Delgado, C.; Delgado Giler, A. G.; della Volpe, D.; Depaoli, D.; Di Girolamo, T.; Di Pierro, F.; Di Venere, L.; Diebold, S.; Dmytriiev, A.; Domínguez, A.; Donini, A.; Doro, M.; Ebr, J.; Eckner, C.; Edwards, T. D. P.; Ekoume, T. R. N.; Elsässer, D.; Evoli, C.; Falceta-Goncalves, D.; Fedorova, E.; Fegan, S.; Feng, Q.; Ferrand, G.; Ferrara, G.; Fiandrini, E.; Fiasson, A.; Filipovic, M.; Fioretti, V.; Fiori, M.; Foffano, L.; Fontaine, G.; Fornieri, O.; Franco, F. J.; Fukami, S.; Fukui, Y.; Gaggero, D.; Galaz, G.; Gammaldi, V.; Garcia, E.; Garczarczyk, M.; Gascon, D.; Gent, A.; Ghalumyan, A.; Gianotti, F.; Giarrusso, M.; Giavitto, G.; Giglietto, N.; Giordano, F.; Giuliani, A.; Glicenstein, J.; Gnatyk, R.; Goldoni, P.; González, M. M.; Gourgouliatos, K.; Granot, J.; Grasso, D.; Green, J.; Grillo, A.; Gueta, O.; Gunji, S.; Halim, A.; Hassan, T.; Heller, M.; Hernández Cadena, S.; Hiroshima, N.; Hnatyk, B.; Hofmann, W.; Holder, J.; Horan, D.; Hörandel, J.; Horvath, P.; Hovatta, T.; Hrabovsky, M.; Hrupec, D.; Hughes, G.; Humensky, T. B.; Hütten, M.; Iarlori, M.; Inada, T.; Inoue, S.; Iocco, F.; Iori, M.; Jamrozy, M.; Janecek, P.; Jin, W.; Jouvin, L.; Jurysek, J.; Karukes, E.; Katarzyński, K.; Kazanas, D.; Kerszberg, D.; Kherlakian, M. C.; Kissmann, R.; Knödlseder, J.; Kobayashi, Y.; Kohri, K.; Komin, N.; Kubo, H.; Kushida, J.; Lamanna, G.; Lapington, J.; Laporte, P.; Leigui de Oliveira, M. A.; Lenain, J.; Leone, F.; Leto, G.; Lindfors, E.; Lohse, T.; Lombardi, S.; Longo, F.; Lopez, A.; López, M.; López-Coto, R.; Loporchio, S.; Luque-Escamilla, P. L.; Mach, E.; Maggio, C.; Maier, G.; Mallamaci, M.; Malta Nunes de Almeida, R.; Mandat, D.; Manganaro, M.; Mangano, S.; Manicò, G.; Marculewicz, M.; Mariotti, M.; Markoff, S.; Marquez, P.; Martí, J.; Martinez, O.; Martínez, M.; Martínez, G.; Martínez-Huerta, H.; Maurin, G.; Mazin, D.; Mbarubucyeye, J. D.; Medina Miranda, D.; Meyer, M.; Miceli, M.; Miener, T.; Minev, M.; Miranda, J. M.; Mirzoyan, R.; Mizuno, T.; Mode, B.; Moderski, R.; Mohrmann, L.; Molina, E.; Montaruli, T.; Moralejo, A.; Morcuende-Parrilla, D.; Morselli, A.; Mukherjee, R.; Mundell, C.; Nagai, A.; Nakamori, T.; Nemmen, R.; Niemiec, J.; Nieto, D.; Nikołajuk, M.; Ninci, D.; Noda, K.; Nosek, D.; Nozaki, S.; Ohira, Y.; Ohishi, M.; Ohtani, Y.; Oka, T.; Okumura, A.; Ong, R. A.; Orienti, M.; Orito, R.; Orlandini, M.; Orlando, S.; Orlando, E.; Ostrowski, M.; Oya, I.; Pagano, I.; Pagliaro, A.; Palatiello, M.; Pantaleo, F. R.; Paredes, J. M.; Pareschi, G.; Parmiggiani, N.; Patricelli, B.; Pavletić, L.; Pe'er, A.; Pecimotika, M.; Pérez-Romero, J.; Persic, M.; Petruk, O.; Pfrang, K.; Piano, G.; Piatteli, P.; Pietropaolo, E.; Pillera, R.; Pilszyk, B.; Pintore, F.; Pohl, M.; Poireau, V.; Prado, R. R.; Prandini, E.; Prast, J.; Principe, G.; Prokoph, H.; Prouza, M.; Przybilski, H.; Pühlhofer, G.; Pumo, M. L.; Queiroz, F.; Quirrenbach, A.; Rainò, S.; Rando, R.; Razzaque, S.; Recchia, S.; Reimer, O.; Reisenegger, A.; Renier, Y.; Rhode, W.; Ribeiro, D.; Ribó, M.; Richtler, T.; Rico, J.; Rieger, F.; Rinchiuso, L.; Rizi, V.; Rodriguez, J.; Rodriguez Fernandez, G.; Rodriguez Ramirez, J. C.; Rojas, G.; Romano, P.; Romeo, G.; Rosado, J.; Rowell, G.; Rudak, B.; Russo, F.; Sadeh, I.; Sæther Hatlen, E.; Safi-Harb, S.; Salesa Greus, F.; Salina, G.; Sanchez, D.; Sánchez-Conde, M.; Sangiorgi, P.; Sano, H.; Santander, M.; Santos, E. M.; Santos-Lima, R.; Sanuy, A.; Sarkar, S.; Saturni, F. G.; Sawangwit, U.; Schussler, F.; Schwanke, U.; Sciacca, E.; Scuderi, S.; Seglar-Arroyo, M.; Sergijenko, O.; Servillat, M.; Seweryn, K.; Shalchi, A.; Sharma, P.; Shellard, R. C.; Siejkowski, H.; Silk, J.; Siqueira, C.; Sliusar, V.; Słowikowska, A.; Sokolenko, A.; Sol, H.; Spencer, S.; Stamerra, A.; Stanič, S.; Starling, R.; Stolarczyk, T.; Straumann, U.; Strišković, J.; Suda, Y.; Suomijarvi, T.; Świerk, P.; Tavecchio, F.; Taylor, L.; Tejedor, L. A.; Teshima, M.; Testa, V.; Tibaldo, L.; Todero Peixoto, C. J.; Tokanai, F.; Tonev, D.; Tosti, G.; Tosti, L.; Tothill, N.; Truzzi, S.; Travnicek, P.; Vagelli, V.; Vallage, B.; Vallania, P.; van Eldik, C.; Vandenbroucke, J.; Varner, G. S.; Vassiliev, V.; Vázquez Acosta, M.; Vecchi, M.; Ventura, S.; Vercellone, S.; Vergani, S.; Verna, G.; Viana, A.; Vigorito, C. F.; Vink, J.; Vitale, V.; Vorobiov, S.; Vovk, I.; Vuillaume, T.; Wagner, S. J.; Walter, R.; Watson, J.; Weniger, C.; White, R.; White, M.; Wiemann, R.; Wierzcholska, A.; Will, M.; Williams, D. A.; Wischnewski, R.; Yanagita, S.; Yang, L.; Yoshikoshi, T.; Zacharias, M.; Zaharijas, G.; Zakaria, A. A.; Zampieri, L.; Zanin, R.; Zaric, D.; Zavrtanik, M.; Zavrtanik, D.; Zdziarski, A. A.; Zech, A.; Zechlin, H.; Zhdanov, V. I.; Živec, M.-- This is an open access article published by IOP Publishing Ltd on behalf of Sissa Medialab. Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI., We provide an updated assessment of the power of the Cherenkov Telescope Array (CTA) to search for thermally produced dark matter at the TeV scale, via the associated gamma-ray signal from pair-annihilating dark matter particles in the region around the Galactic centre. We find that CTA will open a new window of discovery potential, significantly extending the range of robustly testable models given a standard cuspy profile of the dark matter density distribution. Importantly, even for a cored profile, the projected sensitivity of CTA will be sufficient to probe various well-motivated models of thermally produced dark matter at the TeV scale. This is due to CTA's unprecedented sensitivity, angular and energy resolutions, and the planned observational strategy. The survey of the inner Galaxy will cover a much larger region than corresponding previous observational campaigns with imaging atmospheric Cherenkov telescopes. CTA will map with unprecedented precision the large-scale diffuse emission in high-energy gamma rays, constituting a background for dark matter searches for which we adopt state-of-the-art models based on current data. Throughout our analysis, we use up-to-date event reconstruction Monte Carlo tools developed by the CTA consortium, and pay special attention to quantifying the level of instrumental systematic uncertainties, as well as background template systematic errors, required to probe thermally produced dark matter at these energies. © 2021 The Author(s)., We gratefully acknowledge financial support from the following agencies and organisations: State Committee of Science of Armenia, Armenia; The Australian Research Council, Astronomy Australia Ltd, The University of Adelaide, Australian National University, Monash University, The University of New South Wales, The University of Sydney, Western Sydney University, Australia; Federal Ministry of Education, Science and Research, and Innsbruck University, Austria; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Ministry of Science, Technology, Innovations and Communications (MCTIC), and Instituto Serrapilheira, Brasil; Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018, Bulgaria; The Natural Sciences and Engineering Research Council of Canada and the Canadian Space Agency, Canada; CONICYT-Chile grants CATA AFB 170002, ANID PIA/APOYO AFB 180002, ACT 1406, FONDECYT-Chile grants, 1161463, 1170171, 1190886, 1171421, 1170345, 1201582, Gemini-ANID 32180007, Chile; Croatian Science Foundation, Rudjer Boskovic Institute, University of Osijek, University of Rijeka, University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, University of Zagreb, Faculty of Electrical Engineering and Computing, Croatia; Ministry of Education, Youth and Sports, MEYS LM2015046, LM2018105, LTT17006, EU/MEYS CZ.02.1.01/0.0/0.0/16_013/0001403, CZ.02.1.01/0.0/0.0/18_046/0016007 and CZ.02.1.01/0.0/0.0/16_019/0000754, Czech Republic; Academy of Finland (grant nr.317636, 320045, 317383 and 320085), Finland; Ministry of Higher Education and Research, CNRS-INSU and CNRS-IN2P3, CEA-Irfu, ANR, Regional Council Ile de France, Labex ENIGMASS, OSUG2020, P2IO and OCEVU, France; Max Planck Society, BMBF, DESY, Helmholtz Association, Germany; Department of Atomic Energy, Department of Science and Technology, India; Istituto Nazionale di Astrofisica (INAF), Istituto Nazionale di Fisica Nucleare (INFN), MIUR, Istituto Nazionale di Astrofisica (INAF-OABRERA) Grant Fondazione Cariplo/Regione Lombardia ID 2014-1980/RST_ERC, Italy; ICRR, University of Tokyo, JSPS, MEXT, Japan; Netherlands Research School for Astronomy (NOVA), Netherlands Organization for Scientific Research (NWO), Netherlands; University of Oslo, Norway; Ministry of Science and Higher Education, DIR/WK/2017/12, the National Centre for Research and Development and the National Science Centre, UMO-2016/22/M/ST9/00583, Poland; Slovenian Research Agency, grants P1-0031, P1-0385, I0-0033, J1-9146, J1-1700, N1-0111, and the Young Researcher program, Slovenia; South African Department of Science and Technology and National Research Foundation through the South African Gamma-Ray Astronomy Programme, South Africa; The Spanish Ministry of Science and Innovation and the Spanish Research State Agency (AEI) through grants AYA2016-79724-C4-1-P, AYA2016-80889-P, AYA2016-76012-C3-1-P, BES-2016-076342, ESP2017-87055-C2-1-P, FPA2017-82729-C6-1-R, FPA2017-82729-C6-2-R, FPA2017-82729-C6-3-R, FPA2017-82729-C6-4-R, FPA2017-82729-C6-5-R, FPA2017-82729-C6-6-R, PGC2018-095161-B-I00, PGC2018-095512-B-I00; the \Centro de Excelencia Severo Ochoa"program through grants no. SEV-2015-0548, SEV-2016-0597, SEV-2016-0588, SEV-2017-0709; the "Unidad de Excelencia Maria de Maeztu" program through grant no. MDM-2015-0509; the "Ramon y Cajal" programme through grants RYC-2013-14511, RyC-2013-14660, RYC-2017-22665; and the MultiDark Consolider Network FPA2017-90566-REDC. Atraccion de Talento contract no. 2016-T1/TIC-1542 granted by the Comunidad de Madrid; the "Postdoctoral Junior Leader Fellowship" programme from La Caixa Banking Foundation, grants no. LCF/BQ/LI18/11630014 and LCF/BQ/PI18/11630012; the "Programa Operativo" FEDER2014-2020, Consejeria de Economia y Conocimiento de la Junta de Andalucia (ref. 1257737), PAIDI 2020 (ref. P18-FR-1580), and Universidad de Jaen; the Spanish AEI EQC2018-005094-P FEDER 2014-2020; the European Union's "Horizon 2020" research and innovation programme under Marie Sklodowska-Curie grant agreement no. 665919; and the ESCAPE project with grant no. GA:824064, Spain; Swedish Research Council, Royal Physiographic Society of Lund, Royal Swedish Academy of Sciences, The Swedish National Infrastructure for Computing (SNIC) at Lunarc (Lund), Sweden; State Secretariat for Education, Research and Innovation (SERI) and Swiss National Science Foundation (SNSF), Switzerland; Durham University, Leverhulme Trust, Liverpool University, University of Leicester, University of Oxford, Royal Society, Science and Technology Facilities Council, U.K.; U.S. National Science Foundation, U.S. Department of Energy, Argonne National Laboratory, Barnard College, University of California, University of Chicago, Columbia University, Georgia Institute of Technology, Institute for Nuclear and Particle Astrophysics (INPAC-MRPI program), Iowa State University, the Smithsonian Institution, Washington University McDonnell Center for the Space Sciences, The University of Wisconsin and the Wisconsin Alumni Research Foundation, U.S.A. The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreements No 262053 and No 317446. This project is receiving funding from the European Union's Horizon 2020 research and innovation programs under agreement No 676134.

Published
2022

27. A position statement and practical guide to the use of particulate filtering facepiece respirators (N95, FFP2, or equivalent) for South African health workers exposed to respiratory pathogens including Mycobacterium tuberculosis and SARS-CoV-2

Author

Dheda, K, Charalambous, S, Kharat, AS, von Delft, A, van Zyl-SMit, RN, Perumal, R, Allwood, BW, Esmail, A, Wong, ML, Duse, AG, Richards, G, Feldman, C, Mer, M, Nyamande, K, Lalla, U, Koegelenberg, CFN, Venter, F, Dawood, H, Adams, S, Ntusi, NAB, van der Westhuizen, H-M, Moosa, M-YS, van der Westhuizen, NA, Moultrie, H, Nel, J, Hausler, H, Preiser, W, Lasersohn, L, Zar, HJ, and Churchyard, GJ

Abstract

Summary\ud Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is transmitted mainly by aerosol in particles

Published
2021

30. Probing the Structure of SDSS J1004+4112 through Microlensing Analysis of Spectroscopic Data.

Author

Fian, C., Muñoz, J. A., Forés-Toribio, R., Mediavilla, E., Jiménez-Vicente, J., Chelouche, D., Kaspi, S., and Richards, G. T.

Subjects
DATA analysis, ACCRETION disks, QUASARS, GRAVITATIONAL lenses
Abstract

We aim to uncover the structure of the continuum and broad emission line (BEL) emitting regions in the gravitationally lensed quasar SDSS J1004+4112 through unique microlensing signatures. Analyzing 20 spectroscopic observations from 2003 to 2018, we study the striking deformations of various BEL profiles and determine the sizes of their respective emitting regions. We use the emission line cores as a baseline for no microlensing and then apply Bayesian methods to derive the sizes of the Ly α , Si IV, C IV, C III], and Mg II emitting regions, as well as of the underlying continuum-emitting sources. We find that the sizes of the emitting regions for the BELs are a few light-days across, notably smaller than in typical lensed quasars. The asymmetric distortions observed in the BELs suggest that the broad-line region lacks spherical symmetry and is likely confined to a plane. The inferred continuum emitting region sizes are larger than predictions based on standard thin-disk theory by a factor of ∼ 4. We find that the size-wavelength relation is in agreement with that of a geometrically thin and optically thick accretion disk. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1

Author

Wilding, Birgit, Pasqua, A. Elisa, E. A. Chessum, Nicola, Pierrat, Olivier A., Hahner, Tamas, Tomlin, Kathy, Shehu, Erald, Burke, Rosemary, Richards, G. Meirion, Whitton, Bradleigh, Arwert, Esther N., Thapaliya, Arjun, Salimraj, Ramya, van Montfort, Rob, Skawinska, Agi, Hayes, Angela, Raynaud, Florence, Chopra, Rajesh, Jones, Keith, Newton, Gary, and Cheeseman, Matthew D.

Published
2021
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33. An evidence-based approach to assess the use of opioids

Author

Richards, G, Heneghan, C, Aronson, J, Mahtani, K, and Goldacre, B

Subjects
Evidence-based medicine, Epidemiology, Pharmacoepidemiology, Primary health care--Great Britain, Epidemiology--Methodology, Primary health care
Abstract

Background: Since the 1990s, the prescribing of opioids has increased in England and most high-income countries. However, insufficient datasets used in previous research may have underrepresented the extent of the problem. Aims: To assess global and national use of opioids, drivers of suboptimal use, and consider strategies to prevent opioid-related deaths. Methods: I conducted two cross-sectional analyses and two retrospective observational studies, using several datasets, including controlled opioid consumption statistics from the International Narcotic Control Board, the Global Essential Medicines Database of 137 national essential medicines lists, sales of over-the-counter products containing codeine, and the Preventable Deaths Database. I performed a synthesis of pharmacological resources and a systematic review of observational studies to explore factors associated with high-dose opioids. Results: 687 million people (10% of the global population) consumed 89% of the world’s controlled opioids in 2015-17. Countries included a median of 6 opioids (IQR: 5-9; range: 0-19) in national essential medicines lists; morphine (95%), fentanyl (83%), and codeine (69%) were the most common. 31.5 billion units of codeine, costing £2.55 billion, were sold over-the-counter across 31 countries in 2013-19, with 3% and 54% increases respectively. In the UK, 4.75 billion dosage units of codeine in combination with 1711 tonnes of paracetamol and 96 tonnes of ibuprofen, costing £638 million, were purchased over-the-counter in 2013-19. I identified 233 opioid drugs and created the Oxford Catalogue of Opioids (https://www.catalogueofopioids.net/). Five factors were associated with high-dose opioids, including co-prescription of benzodiazepines, depression, Emergency Department visits, unemployment, and being male. There were 176 opioid-related Prevention of Future Deaths reports in 2013-19, with a 262% increase. I created the Preventable Deaths Tracker (https://preventabledeathstracker.net/) and launched the Coroners’ Concerns to Prevent Harms series in BMJ Evidence-Based Medicine. Conclusions: There are persistent disparities and variations in the use of and access to prescribed and non-prescribed opioids. While opioids can be overused or underused, and can cause fatal and non-fatal harms, they still have a place in modern medicine in the right patient, at the right dosage regimen, and for the right reasons. I have outlined future research to serve patient safety, reduce avoidable harms, and improve evidence-based decision-making in clinical practice and policy.

Published
2021

45. 89

Author

Miller, G. A., Bradbury, W. F., Graber, M. E., Bradbury, W. F., Berg, P. S., Bell, A. H., Bradbury, W. F., Robins, Sylvester, Schmitt, Cooper D., Richards, G. H., Zerr, G. B. M., and Boorman, J. M.

Published
1898
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