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Medicinal plants are an excellent source of structurally diverse, bio-active compounds with potential in the fight against cancer. One of the most promising is Scutellaria barbata, prescribed traditionally for the treatment of cancers. Scutebarbatine A is the major diterpenoid, produced in specialized large, peltate trichomes on leaves of S. barbata. It induces dose-dependent apoptosis, specifically in cancer cells. The major class of proteins down-regulated are pro-survival proteins, the Inhibitors of Apoptosis (IAPs), and IAP regulating proteins. We propose that scutebarbatine A works by releasing the molecular brakes (the IAPs) on apoptosis in cell death-evading cancer cells. Comparison between the cytotoxicity of methanolic extracts of S. barbata leaves and decoctions (Ban Zhi Lian) prepared traditionally, showed substantially different chemical compositions and differential induction of apoptosis. Analyses suggest polyvalency between the constituents in both extracts, and ways to produce enhanced chemopreventive preparations for the treatment of cancer.

The European Spallation Source ERIC is being built in Lund, Sweden to complement the existing neutron sources in Europe and worldwide. ESS will be the bright-est neutron source ever built upon completion and aims to have an availability of 95% during steady state opera-tions. The purpose of Machine Protection at ESS is to protect the equipment in order to support the high availability. Due to the distributed nature of Machine Protection numerous design teams are involved to implement Protection Functions. The Machine Protection Development at ESS follows the Functional Protection lifecycle for System-of-systems developed at the facility. This paper focuses on the application of the Functional System Inter-action Process part of the Functional Protection method. To obtain the system interaction model, behavioural requirements and to allocate Protection Functions use case workshops are held. The feasibility of different system architectures and protection function implementations are discussed and simulated by going through fore-seen operational sequences, use cases. The different architectures and use cases are documented using Enter-prise Architect., Proceedings of the 16th Int. Conf. on Accelerator and Large Experimental Control Systems, ICALEPCS2017, Barcelona, Spain

Since the introduction of STPA to a broader audience through the book Engineering a Safer World and the first MIT STAMP Workshop in 2012, the interest in this method of hazard analysis has been ever increasing. During the time of introduction to now, STPA has not only been applied to many different domains, has also been constantly developed and extended. We consider the availability of a professional, state-of-the art software application supporting STPA as a crucial agitator for further evolvement and expansion of STPA. Although some software tools are currently available, we are of the opinion that none fully meets the needs for a productive application of STPA outside of the context of research projects and case studies. Furthermore, we believe enterprises demand not only a professionally developed and highly streamlined software application, but also associated support, such as a proper user manual and instructions, along with regular updates and upgrades. The decision to effectively use STPA requires an investment into more than new software, thorough training of staff and a process supporting lessons learned are crucial. This investment will pay for itself through the additional insights that will be uncovered through the STPA methodology, along with the efficiencies and effectiveness enhanced through the software tool, the investment will pay off double! Stiki - Information Security, headquartered in Reykjavík, Iceland and the Safety-Critical Systems Research Lab at the Zurich University of Applied Sciences in Switzerland have successfully applied for an EU grant to develop a software solution satisfying the above mentioned characteristics. The software solution being developed will share the same framework as the software toolkit Risk Management Studio, developed by Stiki and available on the global market since 2005. The objectives are to allow enterprises to use STPA as standalone methodology through the software, and integrated into an enhanced enterprise risk management framework, enabling efficient risk identification and management. The joint development project bases on the software prototype SAHRA, which extends the UML/SysML case tool Enterprise Architect with the ability to perform STPA and on research projects conducted by both partners in the past. The development work commenced in October 2016 and spans over a total of 30 calendar months. With the poster presented we would not only like to outline the project and its end-result, but also motivate stakeholders interested in participating in this project for example by testing and providing feedback of beta-versions of the application.

The European Spallation Source faces a great challenge in succeeding with its ambitious availability goals. The aim is to construct a machine that allows for 95% availability for neutron beam production. This goal requires a robust protection system that allows for high availability by continuously monitoring and acting on the machine states, in order to avoid long facility downtimes and optimize the operation at any stage. The normal conducting section consists of the first 48 meters of the machine, and performs the initial acceleration, bunching, steering, and focusing of the beam, which sets it up for optimal transition into the superconducting section. Through a fit-for-purpose risk management process, a set of protection functions has been identified. The risk identification, analysis, and treatment were done in compliance with modern safety and ISO standards. This ensures that the risks, in this case downtime and equipment damage, are properly prevented and mitigated. This paper describes this process of defining the protection functions for the normal conducting linac at ESS., Proceedings of the 8th Int. Particle Accelerator Conf., IPAC2017, Copenhagen, Denmark

SAHRA is a tool for STAMP/STPA implemented as a plugin for the popular UML/SysML modeling tool Sparx Systems Enterprise Architect. The poster will present key functions of SAHRA and present some innovative concepts for modeling hierarchical control structures, control loops, STPA Step 1 and STPA Step 2.

Dieser Artikel schlägt eine modellbasierte domänen-spezifische Sprache zur Modellierung von Sicherheitsanalyse nach der STAMP/STPA Methode vor. Im Dokument werden die einzelnen Modellierungskonstrukte detailliert beschrieben, sowie deren Zusammenhänge definiert., The article proposes a model-based domain-specific language for the STAMP/STPA safety analysis technique. The document describes the modeling artefacts and their relationships in detail.

SAHRA (STPA based Hazard and Risk Analysis) as a software tool for STAMP/STPA improves the analysis workflow by not only supporting the complete STPA process but by also offering a unique way to capture Step 1 and 2 using the visual style of mind maps. SAHRA is seamlessly integrated into the widely used UML solution Sparx Systems Enterprise Architect (EA). This integration enables synergies between design of a system and its safety analysis and thus allows to use STPA in the paradigm of safety-guided design.