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Your search keyword '"Raynaud, S"' showing total 237 results
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237 results on '"Raynaud, S"'

1. P057 - Topic: AS04-MDS Biology and Pathogenesis/AS04e-Spliceosome machinery: DNA REPLICATION STRESS DUE TO LOSS OF R-LOOPS IN MYELODYSPLASTIC SYNDROMES WITH SF3B1 MUTATION

Author

Rombaut, D., Lefevre, C., Farhat, B., Bondu, S., Letessier, A., Lesieur-Pasquier, A., Castillo-Guzman, D., Leduc, M., Hartono, S., Chesnais, V., Mangione, R., Boussaid, I., Houy, A., Bouscary, D., Willems, L., Chapuis, N., Kosmider, O., Park, S., Raynaud, S., Cluzeau, T., Clappier, E., Fenaux, P., Ades, L., Margueron, R., Wassef, M., Alsafadi, S., Solary, E., Constantinou, A., Stern, M.-H., Palancade, B., Droin, N., Miotto, B., Chédin, F., and Fontenay, M.

Published
2023
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2. Integrated Genomic Analysis of Breast Cancers

Author

Chaffanet Max, Addou-Klouche L, Adélaïde J, Cornen S, Bekhouche I, Finetti P, Guille A, Sircoulomb F, Raynaud S, Bertucci F, and Birnbaum D

Subjects
breast cancers, genome, transcriptome, epigenome, oncogenes, tumor suppressor genes, Genetics, QH426-470
Abstract

Breast cancer is the most frequent and the most deadly cancer in women in Western countries. Different classifications of disease (anatomoclinical, pathological, prognostic, genetic) are used for guiding the management of patients. Unfortunately, they fail to reflect the whole clinical heterogeneity of the disease. Consequently, molecularly distinct diseases are grouped in similar clinical classes, likely explaining the different clinical outcome between patients in a given class, and the fact that selection of the most appropriate diagnostic or therapeutic strategy for each patient is not done accurately. Today, treatment is efficient in only 70.0- 75.0% of cases overall. Our repertoire of efficient drugs is limited but is being expanded with the discovery of new molecular targets for new drugs, based on the identification of candidate oncogenes and tumor suppressor genes (TSG) functionally relevant in disease. Development of new drugs makes therapeutical decisions even more demanding of reliable classifiers and prognostic/predictive tests. Breast cancer is a complex, heterogeneous disease at the molecular level. The combinatorial molecular origin and the heterogeneity of malignant cells, and the variability of the host background, create distinct subgroups of tumors endowed with different phenotypic features such as response to therapy and clinical outcome. Cellular and molecular analyses can identify new classes biologically and clinically relevant, as well as provide new clinically relevant markers and targets.

Published
2012
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9. The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia

Author

Chapiro, E, Radford-Weiss, I, Bastard, C, Luquet, I, Lefebvre, C, Callet-Bauchu, E, Leroux, D, Talmant, P, Mozziconacci, M-J, Mugneret, F, Struski, S, Raynaud, S, Andrieux, J, Barin, C, Jotterand, M, Mossafa, H, Ramond, S, Terré, C, Lippert, E, Berger, F, Felman, P, Merle-Béral, H, Bernard, O A, Davi, F, Berger, R, and Nguyen-Khac, F

Published
2008
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16. Allogeneic stem cell transplantation improves the outcome of adults with t(1;19)/E2A-PBX1 and t(4;11)/MLL-AF4 positive B-cell acute lymphoblastic leukemia: results of the prospective multicenter LALA-94 study

Author

Vey, N, Thomas, X, Picard, C, Kovascovicz, T, Charin, C, Cayuela, J M, Dombret, H, Dastugue, N, Huguet, F, Bastard, C, Stamatoulas, A, Giollant, M, Tournilhac, O, Macintyre, E, Buzyn, A, Bories, D, Kuentz, M, Dreyfus, F, Delannoy, A, Raynaud, S, Gratecos, N, Bordessoule, D, de Botton, S, Preudhomme, C, Reman, O, Troussard, X, Pigneux, A, Bilhou, C, Vernant, J P, Boucheix, C, and Gabert, J

Published
2006
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17. Prospective multicentric molecular study for poor prognosis fusion transcripts at diagnosis in adult B-lineage ALL patients: the LALA 94 experience

Author

Picard, C, Hayette, S, Bilhou-Nabera, C, Cayuela, J M, Delabesse, E, Frenoy, N, Preudhomme, C, Dupont, M, Bastard, C, Bories, D, Vaerman, J L, Davi, F, Dastugue, N, Raynaud, S, Lafage, M, Deschaseaux, F, Fest, T, Gaub, M P, Lhéritier, V, Thomas, X, Charrin, C, Boucheix, C, Dombret, H, MacIntyre, E, Fière, D, and Gabert, J

Published
2006
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35. Impact of the ocean lateral diffusion on the ENSO-like variability of a global coupled GCM

Author

Raynaud, S., Speich, Sabrina, Guilyardi, Éric, Madec, Gurvan, Laboratoire de physique des océans (LPO), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'océanographie dynamique et de climatologie (LODYC), and Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-GEO-PH]Physics [physics]/Physics [physics]/Geophysics [physics.geo-ph], Physics::Atmospheric and Oceanic Physics
Abstract

A global coupled General Circulation Model is used to investigate effects of the lateral ocean mixing on the amplitude and spectral characteristics of the ENSO-like variability. Three 40-year coupled simulations are analysed. They only differ by the lateral ocean physics parametrized: a horizontal diffusion scheme; an isopycnal scheme; isopycnal scheme with an Eddy Induced Velocity (EIV) term.The Multichannel Singular Spectrum Analysis is used to extract linear modes of variability from each simulation and from observations. The strength of the variability, close to that observed in the horizontal and only-isopycnal simulations, is stronger in the two isopycnal configurations, and more especially when the EIV is added. The dominant periods of the variability, also close to those observed, are also affected by the lateral diffusion: the time scale becomes slightly longer as the complexity of the lateral physics increases.

Published
2000

36. MDS with Isolated Trisomy 8. a Type of MDS Frequently Associated with Myeloproliferative Features? A Report from the GFM

Author

Drevon, Louis, Marceau, Alice, Eclache, Virginie, Raynaud, S. Dominique, Richez, Valentine, Berkaoui, Inès, Maarek, Odile, Cuccuini, Wendy, Lusina, Daniel, Berthon, Celine, Dimicoli-Salazar, Sophie, Bidet, Audrey, Vial, Jean-Philippe, Park, Sophie, Stamatoullas, Aspasia, Vieira Dos Santos, Christina, Braun, Thorsten, Sapena, Rosa, Renneville, Aline, Ades, Lionel, and Fenaux, Pierre

Published
2015
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42. Using MSSA to determine explicitly the oscillatory dynamics of weakly nonlinear climate systems.

Author

Raynaud, S., Yiou, P., Kleeman, R., Speich, S., and Tsonis, A.

Subjects
SPECTRUM analysis, OSCILLATIONS, CLIMATOLOGY, WATER temperature, PHASE space
Abstract

This paper presents a statistical diagnostic to interpret the dynamics of nonlinear variability in models. It consists in applying the Multichannel Singular Spectrum Analysis to the variability of a suitable equation of a dynamical system. This method enables us to evaluate the sensitivity of the oscillatory features of a physical model to tendencies in its mathematical formulation. Hence, responses in amplitude and frequency are determined in the phase space of the model. The example of interannual variability of the tropical Pacific climate through the analysis the Sea Surface Temperature equation of a hybrid coupled model is used to illustrate and validate the methodology. [ABSTRACT FROM AUTHOR]

Published
2005
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43. Interannual-to-decadal variability of North Atlantic air-sea CO2 fluxes.

Author

Raynaud, S., Aumont, O., Rodgers, K. B., Yiou, P., and Orr, J. C.

Subjects
NORTH Atlantic oscillation, OCEAN-atmosphere interaction, TEMPERATURE inversions, ATMOSPHERIC temperature, TEMPERATURE
Abstract

The magnitude of the interannual variability of North Atlantic air-sea CO2 fluxes remains uncertain. Fluxes inferred from atmospheric inversions have large variability, whereas those simulated by ocean models have small variability. Part of the difference is that unlike typical atmospheric inversions, ocean models come with spatial resolution at the sub-basin scale. Here we explore sub-basin-scale spatiotemporal variability in the North Atlantic in one ocean model in order to better understand why the the North Atlantic basin may well contribute very little to the global variability of air-sea CO2 flux. We made two simulations with a biogeochemical model coupled to a global ocean general circulation model (GM), which itself was forced by 55-year NCEP reanalysis fields. In the first simulation, atmospheric CO2 was maintained at the preindustrial level (278 ppmv); in the second simulation, atmospheric CO2 followed the observed increase. Simulated air-sea CO2 fluxes and associated variables were analysed with a statistical tool known as multichannel singular spectrum analysis (MSSA). We found that the subtropical gyre is not the largest contributor to the overall, basinwide variability, in contrast to previous suggestions. The subpolar gyre and the intergyre region (the transition area between subpolar and subtropical gyres) also contribute with multipolar anomalies at multiple frequencies: these tend to cancel one another in terms of the basin-wide air-sea CO2 flux. We found a strong correlation between the air-sea CO2 fluxes and the North Atlantic Oscillation (NAO), but only if one takes into account time lags as does MSSA (maximum r=0.64 for lags between 1 and 3 years). The contribution of anthropogenic CO2 to total variability was negligible at interannual time scales, whereas at the decadal (13-year) time scale, it increased variability by 30%. [ABSTRACT FROM AUTHOR]

Published
2005
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50. Cytogenetic abnormalities associated with the t(12;21): a collaborative study of 169 children with t(12;21)-positive acute lymphoblastic leukemia.

Author

Raynaud, S D, Dastugue, N, Zoccola, D, Shurtleff, S A, Mathew, S, and Raimondi, S C

Subjects
*LYMPHOBLASTIC leukemia, *PROGNOSIS, *CHROMOSOME abnormalities, *CHROMOSOMES, *CLINICAL trials, *COMPARATIVE studies, *KARYOTYPES, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *EVALUATION research, *RANDOMIZED controlled trials
Abstract

The t(12;21)(p13;q22) is a cryptic abnormality observed in 25% of children with B-lineage acute lymphoblastic leukemia (ALL), associated with a favorable prognosis. To determine whether specific cytogenetic abnormalities accompany the t(12;21), we analyzed the cytogenetic profiles of blast cells from 169 ALL cases positive for the t(12;21), previously identified by molecular methods. Only 13.6% of samples had normal karyotypes. Structural changes were detected in 89.7% of abnormal karyotypes, and numerical abnormalities in 47%. Rearrangements of 12p were the most frequent structural aberration (57 out of 146 patients with chromosomal abnormalities). Nonspecific deletions of chromosomes 6 and 9 were also found. The most frequent numerical abnormalities was trisomy for chromosomes 21. Blast cells were pseudodiploid (45.6%), hyperdiploid with 47 to 51 chromosomes (24.3%), hypodiploid with 44 to 45 chromosomes (10%), near-triploid (0.6%), or near-tetraploid (5.9%). Our results show that the t(12;21) is not associated with hyperdiploidy of 52 to 68 chromosomes or with the prognostic t(1;19), t(4;11) or t(9;22). Only children with B-lineage ALL who lack these abnormalities detected by conventional cytogenetics will probably benefit from additional testing by molecular methods to detect the t(12;21). [ABSTRACT FROM AUTHOR]

Published
1999
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