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1,347 results on '"Ravi, M."'

3. A phase III randomized-controlled study of safety and immunogenicity of DTwP-HepB-IPV-Hib vaccine (HEXASIIL®) in infants

Author

Sharma, Hitt, Parekh, Sameer, Pujari, Pramod, Shewale, Sunil, Desai, Shivani, Kawade, Anand, Lalwani, Sanjay, Ravi, M. D., Kamath, Veena, Mahopatra, Jagannath, Kulkarni, Ganesh, Tayade, Deepak, Ramanan, Padmasani Venkat, Uttam, Kheya Ghosh, Rawal, Lalit, Gawande, Avinash, Kumar, N. Ravi, Tiple, Nishikant, Vagha, Jayant, Thakkar, Pareshkumar, Khandgave, Prashant, Deshmukh, Bhaskar Jedhe, Agarwal, Anurag, Dogar, Vikas, Gautam, Manish, Jaganathan, K. S., Kumar, Rakesh, Sharma, Inderjit, and Gairola, Sunil

Published
2024
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7. Abstracts of the Cell Therapy Transplant Canada 2023 Annual Conference

Author

Stephanie A. Maier, Imran Ahmad, Tobias Berg, Susan Berrigan, Mahmoud Elsawy, Alejandro Garcia-Horton, Wilson Lam, Alix Lapworth, Luciana Melo Garcia, Ravi M. Shah, Ram Vasudevan Nampoothiri, and Jean-Sébastien Delisle

Subjects
hematopoietic cell transplantation, cell therapy, CAR T-cell therapy, GvHD, lymphoma, leukemia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

On behalf of Cell Therapy Transplant Canada (CTTC), we are pleased to present the Abstracts of the CTTC 2023 Annual Conference. The conference was held in-person, 31 May–2 June 2023, in Halifax, Nova Scotia at the Westin Nova Scotian hotel. Poster authors presented their work during a lively and engaging welcome reception on Thursday, 1 June, and oral abstract authors were featured during the oral abstract session in the afternoon of Friday, 2 June 2023. Twenty-three (23) abstracts were selected for presentation as posters and four (4) as oral presentations. Abstracts were submitted within four categories: (1) Basic/Translational Sciences, (2) Clinical Trials/Observations, (3) Laboratory/Quality, and (4) Pharmacy/Nursing/Other Transplant Support. The top four (4) oral abstracts and top four (4) poster abstracts were selected to receive an award. All of these were marked as “Award Recipient” within the relevant category. We congratulate all the presenters on their research and contributions to the field.

Published
2024
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8. A high fiber diet or supplementation with Lactococcus lactis subspecies cremoris to pregnant mice confers protection against intestinal injury in adult offspring

Author

Maria E. Barbian, Joshua A. Owens, Crystal R. Naudin, Patricia Denning, Ravi M. Patel, and Rheinallt M. Jones

Subjects
Butyrate, probiotics, antenatal diet, pregnancy, diet, colitis, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

ABSTRACTThe diet during pregnancy, or antenatal diet, influences the offspring’s intestinal health. We previously showed that antenatal butyrate supplementation reduces injury in adult murine offspring with dextran sulfate sodium (DSS)-induced colitis. Potential modulators of butyrate levels in the intestine include a high fiber diet or dietary supplementation with probiotics. To test this, we supplemented the diet of pregnant mice with high fiber, or with the probiotic bacteria Lactococcus lactis subspecies cremoris or Lactobacillus rhamnosus GG. We then induced chronic colitis with DSS in their adult offspring. We demonstrate that a high fiber antenatal diet, or supplementation with Lactococcus lactis subspecies cremoris during pregnancy diminished the injury from DSS-induced colitis in offspring. These data are evidence that antenatal dietary interventions impact offspring gut health and define the antenatal diet as a therapeutic modality to enhance offspring intestinal health.

Published
2024
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9. Engineered immunologic niche monitors checkpoint blockade response and probes mechanisms of resistance

Author

Ravi M. Raghani Ph.D., Russell R. Urie Ph.D., Jeffrey A. Ma, Guillermo Escalona, Ian A. Schrack, Katarina M. DiLillo, Pridvi Kandagatla M.D., Joseph T. Decker Ph.D., Aaron H. Morris Ph.D., Kelly B. Arnold Ph.D., Jacqueline S. Jeruss M.D., Ph.D., and Lonnie D. Shea Ph.D.

Subjects
biomaterials, checkpoint blockade, immunotherapy resistance, metastasis, therapy monitoring, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Antibodies to programmed cell death protein 1 (anti‐PD‐1) have become a promising immunotherapy for triple negative breast cancer (TNBC), blocking PD‐L1 signaling from pro‐tumor cells through T cell PD‐1 receptor binding. Nevertheless, only 10%–20% of PD‐L1+ metastatic TNBC patients who meet criteria benefit from immune checkpoint blockade (ICB), and biomarkers to predict patient response have been elusive. We have previously developed an immunological niche, consisting of a microporous implant in the subcutaneous space, that supports tissue formation whose immune composition is consistent with that within vital organs. Herein, we investigated dynamic gene expression within this immunological niche to provide biomarkers of response to anti‐PD‐1. In a 4T1 model of metastatic TNBC, we observed sensitivity and resistance to anti‐PD‐1 based on primary tumor growth and survival. The niche was biopsied before, during, and after anti‐PD‐1 therapy, and analyzed for cell types and gene expression indicative of treatment refractivity. Myeloid cell‐to‐lymphocyte ratios were altered between ICB‐sensitivity and resistance. Longitudinal analysis of gene expression implicated dynamic myeloid cell function that stratified sensitivity from resistance. A niche‐derived gene signature predicted sensitivity or resistance prior to therapy. Analysis of the niche to monitor immunotherapy response presents a new opportunity to personalize care and investigate mechanisms underlying treatment resistance. Summary: A remote implant identified biomarkers that predict anti‐PD‐1 response before therapy, providing a unique tool to understand heterologous immunotherapy resistance in triple negative breast cancer.

Published
2024
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12. Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

Author

Green, Charles E., Tyson, Jon E., Heyne, Roy J., Hintz, Susan R., Vohr, Betty R., Bann, Carla M., Das, Abhik, Bell, Edward F., Debsareea, Sana Boral, Stephens, Emily, Gantz, Marie G., Petrie Huitema, Carolyn M., Johnson, Karen J., Watterberg, Kristi L., Mosquera, Ricardo, Peralta-Carcelen, Myriam, Wilson-Costello, Deanne E., Colaizy, Tarah T., Maitre, Nathalie L., Merhar, Stephanie L., Adams-Chapman, Ira, Fuller, Janell, Hartley-McAndrew, Michelle E., Malcolm, William F., Winter, Sarah, Duncan, Andrea F., Myer, Gary J., Kicklighter, Stephen D., Wyckoff, Myra H., DeMauro, Sara B., Hibbs, Anna Maria, Stoll, Barbara J., Carlo, Waldemar A., Van Meurs, Krisa P., Rysavy, Matthew A., Patel, Ravi M., Sánchez, Pablo J., Laptook, Abbot R., Cotten, C. Michael, D’Angio, Carl T., and Walsh, Michele C.

Published
2023
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19. A synthetic metastatic niche reveals antitumor neutrophils drive breast cancer metastatic dormancy in the lungs

Author

Jing Wang, Ramon Ocadiz-Ruiz, Matthew S. Hall, Grace G. Bushnell, Sophia M. Orbach, Joseph T. Decker, Ravi M. Raghani, Yining Zhang, Aaron H. Morris, Jacqueline S. Jeruss, and Lonnie D. Shea

Subjects
Science
Abstract

Abstract Biomaterial scaffolds mimicking the environment in metastatic organs can deconstruct complex signals and facilitate the study of cancer progression and metastasis. Here we report that a subcutaneous scaffold implant in mouse models of metastatic breast cancer in female mice recruits lung-tropic circulating tumor cells yet suppresses their growth through potent in situ antitumor immunity. In contrast, the lung, the endogenous metastatic organ for these models, develops lethal metastases in aggressive breast cancer, with less aggressive tumor models developing dormant lungs suppressing tumor growth. Our study reveals multifaceted roles of neutrophils in regulating metastasis. Breast cancer-educated neutrophils infiltrate the scaffold implants and lungs, secreting the same signal to attract lung-tropic circulating tumor cells. Second, antitumor and pro-tumor neutrophils are selectively recruited to the dormant scaffolds and lungs, respectively, responding to distinct groups of chemoattractants to establish activated or suppressive immune environments that direct different fates of cancer cells.

Published
2023
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20. Robust Meta-Model for Predicting the Likelihood of Receiving Blood Transfusion in Non-traumatic Intensive Care Unit Patients

Author

Alireza Rafiei, Ronald Moore, Tilendra Choudhary, Curtis Marshall, Geoffrey Smith, John D. Roback, Ravi M. Patel, Cassandra D. Josephson, and Rishikesan Kamaleswaran

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Background: Blood transfusions, crucial in managing anemia and coagulopathy in intensive care unit (ICU) settings, require accurate prediction for effective resource allocation and patient risk assessment. However, existing clinical decision support systems have primarily targeted a particular patient demographic with unique medical conditions and focused on a single type of blood transfusion. This study aims to develop an advanced machine learning-based model to predict the probability of transfusion necessity over the next 24 h for a diverse range of non-traumatic ICU patients. Methods: We conducted a retrospective cohort study on 72,072 non-traumatic adult ICU patients admitted to a high-volume US metropolitan academic hospital between 2016 and 2020. We developed a meta-learner and various machine learning models to serve as predictors, training them annually with 4-year data and evaluating on the fifth, unseen year, iteratively over 5 years. Results: The experimental results revealed that the meta-model surpasses the other models in different development scenarios. It achieved notable performance metrics, including an area under the receiver operating characteristic curve of 0.97, an accuracy rate of 0.93, and an F1 score of 0.89 in the best scenario. Conclusion: This study pioneers the use of machine learning models for predicting the likelihood of blood transfusion receipt in a diverse cohort of critically ill patients. The findings of this evaluation confirm that our model not only effectively predicts transfusion reception but also identifies key biomarkers for making transfusion decisions.

Published
2024
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29. Early-Life Outcomes in Relation to Social Determinants of Health for Children Born Extremely Preterm

Author

Jobe, Alan H., Caplan, Michael S., Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Alksninis, Barbara, Bishop, Carmena, Burke, Robert T., Caskey, Melinda, Hoffman, Laurie, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Lamberson, Vita, Leach, Teresa M., Little, Emilee, McGowan, Elisabeth C., Stephens, Bonnie E., Vieira, Elisa, St. Pierre, Lucille, Ventura, Suzy, Watson, Victoria E., Hibbs, Anna Maria, Walsh, Michele C., Wilson-Costello, Deanne E., Newman, Nancy S., Bhola, Monika, Payne, Allison H., Siner, Bonnie S., Yalcinkaya, Gulgun, Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Scott, Allison, Parimi, Prabhu S., Gaetano, Lisa, Poindexter, Brenda B., Schibler, Kurt, Kallapur, Suhas G., Donovan, Edward F., Merhar, Stephanie, Grisby, Cathy, Yolton, Kimberly, Alexander, Barbara, Beiersdorfer, Traci, Bridges, Kate, Cahill, Tanya E., Dudley, Juanita, Fischer, Estelle E., Gratton, Teresa L., Hayes, Devan, Hessling, Jody, Jackson, Lenora D., Kirker, Kristin, Mincey, Holly L., Muthig, Greg, Stacey, Sara, Steichen, Jean J., Tepe, Stacey, Thompson, Julia, Wuertz, Sandra, Cotten, C. Michael, Goldberg, Ronald N., Goldstein, Ricki F., Malcolm, William F., Mago-Shah, Deesha, Ashley, Patricia L., Finkle, Joanne, Auten, Kathy J., Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Lohmeyer, Melody B., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Talbert, Jennifer, Warner, Diane, Trembath, Andrea, O'Shea, T. Michael, Wereszczak, Janice, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, White, Donna, Patel, Ravi M., Carlton, David P., Stoll, Barbara J., Hale, Ellen C., Loggins, Yvonne C., Adams-Chapman, Ira, Blackwelder, Ann, Bottcher, Diane I., Carter, Sheena L., Kendrick-Allwood, Salathiel, Laursen, Judith, LaRossa, Maureen Mulligan, Mackie, Colleen, Sanders, Amy, Seabrook, Irma, Smikle, Gloria, Wineski, Lynn C., Higgins, Rosemary D., Bremer, Andrew A., Archer, Stephanie Wilson, Sokol, Gregory M., Dusick, Anna M., Papile, Lu Ann, Gunn, Susan, Hamer, Faithe, Harmon, Heidi M., Herron, Dianne E., Hines, Abbey C., Lytle, Carolyn, Miller, Lucy C., Minnich, Heike M., Richard, Leslie, Smiley, Lucy, Wilson, Leslie Dawn, Tyson, Jon E., Kennedy, Kathleen A., Khan, Amir M., Duncan, Andrea, Mosquera, Ricardo, Stephens, Emily K., McDavid, Georgia E., Alaniz, Nora I., Allain, Elizabeth, Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Eason, Elizabeth, Evans, Patricia W., Garcia, Carmen, Green, Charles, Hall, Donna, Harris, Beverly Foley, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Lis, Anna E., Martin, Karen, Martin, Sara C., Mason, Carrie M., McKee, Shannon, Morris, Brenda H., Rennie, Kimberly, Rodgers, Shawna, Siddiki, Saba Khan, Simmons, Maegan C., Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Slaughter, Jonathan L., Yeates, Keith O., Keim, Sarah, Maitre, Nathalie L., Timan, Christopher J., Luzader, Patricia, Clark, Erna, Fortney, Christine A., Gutentag, Julie, Park, Courtney, Shadd, Julie, Sullivan, Margaret, Stein, Melanie, Nelin, Mary Ann, Newton, Julia, Small, Kristi, Burkhardt, Stephanie, Purnell, Jessica, Pietruszewski, Lindsay, Levengood, Katelyn, Batterson, Nancy, Morehead, Pamela, Carey, Helen, Yoseff-Salameh, Lina, Sullivan, Rox Ann, Hague, Cole, Grothause, Jennifer, Fearns, Erin, Fowler, Aubrey, Notestine, Jennifer, Tonneman, Jill, Hay, Krystal, Chao, Michelle, Warnimont, Kyrstin, Marzec, Laura, Miller, Bethany, Beckford, Demi R., Baugher, Hallie, DeSantis, Brittany, Hanlon, Cory, McCool, Jacqueline, Das, Abhik, Gantz, Marie G., Bann, Carla M., Wallace, Dennis, Crawford, Margaret M., Gabrio, Jenna, Leblond, David, Newman, Jamie E., Petrie Huitema, Carolyn M., O'Donnell Auman, Jeanette, Poole, W. Kenneth, Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Chock, Valerie Y., Stevenson, David K., Adams, Marian M., Ball, M. Bethany, Bentley, Barbara, Bruno, Elizabeth, Davis, Alexis S., Elena DeAnda, Maria, DeBattista, Anne M., Huffman, Lynne C., Ismael, Magdy, Kohn, Jean G., Krueger, Casey, Lowe, Janice, Lucash, Ryan E., Palmquist, Andrew W., Patel, Jessica, Proud, Melinda S., Reichert, Elizabeth N., John, Nicholas H. St., Sivakumar, Dharshi, Taylor, Heather L., Wager, Natalie, Williams, R. Jordan, Weiss, Hali, Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Church, Paige T., Sibley, Cecelia E., Brussa, Ana K., Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Nelson, Kathleen G., Bailey, Kirstin J., Biasini, Fred J., Chopko, Stephanie A., Collins, Monica V., Cosby, Shirley S., Johnston, Kristen C., Moses, Mary Beth, Patterson, Cryshelle S., Phillips, Vivien A., Preskitt, Julie, Rector, Richard V., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, Bell, Edward F., Colaizy, Tarah T., Widness, John A., Brumbaugh, Jane E., Acarregui, Michael J., Johnson, Karen J., Eastman, Diane L., Goeke, Claire A., Schmelzel, Mendi L., Walker, Jacky R., Baack, Michelle L., Hogden, Laurie A., Broadbent, Megan, Elenkiwich, Chelsey, Henning, Megan M., Van Muyden, Sarah, Ellsbury, Dan L., Campbell, Donia B., Tud, Tracy L., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Fajardo-Hiriart, Sylvia, Rigaud, Arielle, Calejo, Maria, Frade Eguaras, Silvia M., Berkowits, Michelle Harwood, Garcia, Andrea, Pierre, Helina, Stoerger, Alexandra, Watterberg, Kristi L., Fuller, Janell, Ohls, Robin K., Beauman, Sandra Sundquist, Lacy, Conra Backstrom, Duncan, Andrea F., Hanson, Mary, Hartenberger, Carol, Kuan, Elizabeth, Lowe, Jean R., Thomson, Rebecca A., DeMauro, Sara B., Eichenwald, Eric C., Schmidt, Barbara, Kirpalani, Haresh, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Catts, Christine, Cook, Noah, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Ghavam, Sarvin, Hurt, Hallam, Snyder, Jonathan, Vangala, Saritha, Ziolkowski, Kristina, D'Angio, Carl T., Phelps, Dale L., Guillet, Ronnie, Myers, Gary J., Andrews-Hartley, Michelle, Johnson, Julie Babish, Binion, Kyle, Bowman, Melissa, Boylin, Elizabeth, Burnell, Erica, Coleman, Kelly R., Fallone, Cait, Farooq, Osman, Hunn, Julianne, Hust, Diane, Jensen, Rosemary L., Jones, Rachel, Kachelmeyer, Jennifer, Kushner, Emily, Maffett, Deanna, McKee, Kimberly G., Merzbach, Joan, Orme, Constance, Prinzing, Diane, Reubens, Linda J., Rochez, Daisy, Rowan, Mary, Sabaratnam, Premini, Scorsone, Ann Marie, Wadkins, Holly I.M., Yost, Kelley, Zwetsch, Lauren, Lakshminrusimha, Satyan, Reynolds, Anne Marie, Sacilowski, Michael G., Guilford, Stephanie, Li, Emily, Williams, Ashley, Zorn, William A., Wyckoff, Myra H., Brion, Luc P., Salhab, Walid A., Rosenfeld, Charles R., Heyne, Roy J., Vasil, Diana M., Adams, Sally S., Chen, Lijun, De Leon, Maria M., Eubanks, Francis, Guzman, Alicia, Hensley, Gaynelle, Heyne, Elizabeth T., Lee, Lizette E., Leps, Melissa H., Madden, Linda A., McDougald, E. Rebecca, Miller, Nancy A., Morgan, Janet S., Pavageau, Lara, Sepulveda, Pollieanna, Tolentino-Plata, Kristine, Boatman, Cathy Twell, Vera, Azucena, Waterbury, Jillian, Yoder, Bradley A., Baserga, Mariana, Faix, Roger G., Winter, Sarah, Minton, Stephen D., Sheffield, Mark J., Rau, Carrie A., Baker, Shawna, Bird, Karie, Burnett, Jill, Christensen, Susan, Cole-Bledsoe, Laura, Davis, Brandy, Elmont, Jennifer O., Jensen, Jennifer J., Loertscher, Manndi C., Jordan, Jamie, Marchant, Trisha, Maxson, Earl, McGrath, Kandace M., Osborne, Karen A., Parry, D. Melody, Reich, Brixen A., Schaefer, Susan T., Spencer, Cynthia, Steffen, Michael, Tice, Katherine, Weaver-Lewis, Kimberlee, Woodbury, Kathryn D., Zanetti, Karen, Dillard, Robert G., Washburn, Lisa K., Jackson, Barbara G., Peters, Nancy, Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Sood, Beena G., Natarajan, Girija, Pappas, Athina, Abramczyk, Katherine, Agarwal, Prashant, Bajaj, Monika, Bara, Rebecca, Billian, Elizabeth, Chawla, Sanjay, Childs, Kirsten, De Jesus, Lilia C., Driscoll, Debra, February, Melissa, Goldston, Laura A., Johnson, Mary E., Muran, Geraldine, Panaitescu, Bogdan, Prentiss, Jeannette E., White, Diane, Woldt, Eunice, Barks, John, Wiggins, Stephanie A., Christensen, Mary K., Carlson, Martha D., Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Williams, Joanne, Romano, Elaine, Vohr, Betty R., Travers, Colm P., and Hintz, Susan R.

Published
2023
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32. Early brain and abdominal oxygenation in extremely low birth weight infants

Author

Chock, Valerie Y., Smith, Emily, Tan, Sylvia, Ball, M. Bethany, Das, Abhik, Hintz, Susan R., Kirpalani, Haresh, Bell, Edward F., Chalak, Lina F., Carlo, Waldemar A., Cotten, C. Michael, Widness, John A., Kennedy, Kathleen A., Ohls, Robin K., Seabrook, Ruth B., Patel, Ravi M., Laptook, Abbot R., Mancini, Toni, Sokol, Gregory M., Walsh, Michele C., Yoder, Bradley A., Poindexter, Brenda B., Chawla, Sanjay, D’Angio, Carl T., Higgins, Rosemary D., and Van Meurs, Krisa P.

Published
2022
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34. Chemical composition, pesticidal activities and in-silico investigation of Hedychium spicatum Sm. chloroform extract

Author

AVNEESH RAWAT, OM PRAKASH, KIRTI NAGARKOTI, RAVENDRA KUMAR, ASHOK K. VERMA, SATYA KUMAR, RAVI M. SRIVASTAVA, MAMTA LATWAL, and GANESH PANDEY

Subjects
Curvularia lunata, Hedychium spicatum, in silico, Meloidogyne incognita, Raphanus raphanistrum, Spodoptera litura, Science
Abstract

Abstract The present study aimed to identify the bioactive constituents in the chloroform extract of H. spicatum rhizomes (HS-RCLE), further evaluated for its in-vitro pesticidal activities validating via molecular docking techniques. GC/MS analysis of HS-RCLE identified 14 compounds contributing 84.1 % of the total composition. The extract was dominated by oxygenated sesquiterpenes (43.1 %) with curcumenone (25.2 %) and coronarin E (14.8 %) as the major compounds. The extract recorded 89.4 % egg hatchability inhibition and 82.6 % immobility of Meloidogyne incognita, 66.7 % insecticidal activity on Spodoptera litura, 100 % phytotoxic activity on Raphanus raphanistrum seeds, and 74.7 % anti-fungal activity on Curvularia lunata at the respective highest dose studied. The biological activities were furthermore validated by using docking studies on certain proteins/enzymes namely acetylcholinesterase (PBD ID: IC2O), carboxylesterase (PDB ID: 1CI8), acetohydroxyacid synthase (PBD ID: 1YHZ) and trihydroxy naphthalene reductase (PBD ID: 3HNR). The bioactivity of the major constituents of the extract was predicted with the help of in silico PASS studies. HS-RCLE was observed to be a viable alternative source of natural pesticidal agents and paves the way for further studies on its mechanistic approaches and field trials to ascertain its pesticidal studies.

Published
2023
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43. Determination of Unstretched Laminar Burning Velocity by Simultaneous Measurements of Flame Radius and Pressure-Time Trace Using Constant Volume Method.

Author

Jangir, Vikas, Ray, Anjan, and Ravi, M. R.

Subjects
BURNING velocity, COMBUSTION chambers, LEAN combustion, AIR pressure, VELOCITY measurements, FLAME
Abstract

Values of laminar burning velocity obtained by the constant volume method suffer from the inaccuracies introduced by the semi-analytical burned gas mass fraction model and flame stretch. A cylindrical combustion chamber with full optical access was developed in the present study, enabling the photography of the flame until the flame touches the inner wall of the combustion chamber. This enables direct visualization of the flame, thus eliminating the dependency on burned gas mass fraction models. The values of laminar burning velocity obtained by simultaneous measurement of flame radius and pressure-time data using the constant volume method are not stretch-free. This paper also develops a methodology for stretch correction based on the determined laminar burning velocity. Experiments were performed on mixtures of methane and air at initial pressures (0.8–1.05 bar), initial temperatures (293–320 K) and equivalence ratios (0.8–1.2). Stretch-corrected laminar burning velocity for lean, stoichiometric, and rich methane-air flames has been obtained in the present study, and the results obtained are validated against available experimental data and 1-D flame computations. It is expected that the proposed method significantly reduces the inaccuracies in laminar burning velocity obtained by the constant volume method. [ABSTRACT FROM AUTHOR]

Published
2024
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45. A prospective study on clinical outcome of primary nailing in open Type I to Type IIIA tibial diaphyseal fractures

Author

Kiran Hari, K M Srinath, and Ravi M Daddimani

Subjects
debridement, open tibia fractures, primary nailing, Orthopedic surgery, RD701-811
Abstract

Background and Objectives: Tibia is a superficial long bone, with one third of its surface being subcutaneous. An increasing incidence of road traffic accidents, farm accidents, gunshot wound predisposes it for open fracture. Open fractures of the tibia are the most common open long bone fractures. High-energy trauma is the primary mechanism of injury, with over 50% of cases being attributed to road traffic accidents are frequently contaminated. The treatment of open tibia fractures is still controversial. This prospective study was conducted at a tertiary care trauma center to evaluate the functional outcome and complications following primary debridement and nailing in type I to type IIIA open tibia fractures. Materials and Methods: A total of 30 patients diagnosed with open tibial diaphyseal fractures, who underwent primary debridement and fixation with intramedullary interlocking nail were included in the study and type III B, type III C open fractures were excluded. Patients were followed for a period of 12 months and assessed using Modified Ketenjian criteria and Johner − Wruhs' criteria. Results: Out of 30 patients who underwent primary nailing for open tibia fractures, 66.67% had excellent, 26, 67% good, and 6.66% of patients had fair results. 93.33% of the patients had union within 9 months and 6.66% of the cases had delayed union. Conclusion: Primary intramedullary interlocking nailing in open tibia fractures is a good treatment option, it aids early patient mobilization and early resume to work. It avoids multiple surgical procedures and promotes early fracture union.

Published
2022
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46. A comprehensive review on various cooling techniques to decrease an operating temperature of solar photovoltaic panels

Author

Mohammed Shoaib Sheik, Pallabi Kakati, Devendra Dandotiya, Udaya Ravi M, and Ramesh C S

Subjects
Solar PV panel (SPV), Photovoltaic operating temperature, Phase change materials (PCM), PV cooling methods, Renewable energy sources, TJ807-830, Agriculture (General), S1-972
Abstract

At present solar power is considered to be one of the most predominant non-conventional and renewable resources when compared with other resources. It does not produce toxic pollutants like conventional fuels while converting them into electric power. Photovoltaic (PV) power generation will be varying continuously according to climatic conditions. The variation in irradiation, wind speed, temperature, and soling affects the power produced by the panel. The operating temperature of the photovoltaic panel plays a vital role during the energy conversion process. PV panel excessive surface operating temperatures and high ambient temperature results in overheating of panels, which in turn significantly decreases the lifetime, efficiencies, and increased payback period of the system. To address these challenges, different cooling approaches in restricting the panel to nominal operating temperature.In light of the above, a comprehensive review is presented on the different cooling techniques resulting in enhancing the performance of solar panels. Air-based, water-based cooling systems, phase change material (PCM), and hybrid cooling by using PCM, nanomaterials, and nanofluids have been researched to ensure reduced panel degradation. The effectiveness of each cooling approach and performance enhancement of the PV panel will also be reported. This review outlines that water-based cooling is better than air-based cooling unless recovered heat is particularly utilized for domestic applications. However, cooling techniques involving the combination of PCM with nanoparticles usage, make the cooling system more effective when compared with water-based systems. The usage of different PCMs and their properties are presented in this review.

Published
2022
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49. Myeloid cell reprogramming alleviates immunosuppression and promotes clearance of metastatic lesions

Author

Ravi M. Raghani, Jeffrey A. Ma, Yining Zhang, Sophia M. Orbach, Jing Wang, Mina Zeinali, Sunitha Nagrath, Sandeep Kakade, Qichen Xu, Joseph R. Podojil, Tushar Murthy, Adam Elhofy, Jacqueline S. Jeruss, and Lonnie D. Shea

Subjects
metastasis, polymeric nanoparticles, immune cell reprogramming, cancer immunotherapy, triple negative breast cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Suppressive myeloid cells, including monocyte and neutrophil populations, play a vital role in the metastatic cascade and can inhibit the anti-tumor function of cytotoxic T-cells. Cargo-free polymeric nanoparticles (NPs) have been shown to modulate innate immune cell responses in multiple pathologies of aberrant inflammation. Here, we test the hypothesis that the intravenous administration of drug-free NPs in the 4T1 murine model of metastatic triple-negative breast cancer can reduce metastatic colonization of the lungs, the primary metastatic site, by targeting the pro-tumor immune cell mediators of metastatic progression. In vivo studies demonstrated that NP administration reprograms the immune milieu of the lungs and reduces pulmonary metastases. Single-cell RNA sequencing of the lungs revealed that intravenous NP administration alters myeloid cell phenotype and function, skewing populations toward inflammatory, anti-tumor phenotypes and away from pro-tumor phenotypes. Monocytes, neutrophils, and dendritic cells in the lungs of NP-treated mice upregulate gene pathways associated with IFN signaling, TNF signaling, and antigen presentation. In a T-cell deficient model, NP administration failed to abrogate pulmonary metastases, implicating the vital role of T-cells in the NP-mediated reduction of metastases. NPs delivered as an adjuvant therapy, following surgical resection of the primary tumor, led to clearance of established pulmonary metastases in all treated mice. Collectively, these results demonstrate that the in vivo administration of cargo-free NPs reprograms myeloid cell responses at the lungs and promotes the clearance of pulmonary metastases in a method of action dependent on functional T-cells.

Published
2022
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50. Variation in Neonatal Transfusion Practice

Author

Mast, A.E., Hod, E.A., Custer, B.S., Vichinsky, E.P., Spencer, B.R., Mathew, S.M., Harris, D.R., Busch, M.P., Norris, P.J., Ness, P.M., Kleinman, S.H., Tamburro, R., Glynn, S.A., Malkin, K., Patel, Ravi M., Hendrickson, Jeanne E., Nellis, Marianne E., Birch, Rebecca, Goel, Ruchika, Karam, Oliver, Karafin, Matthew S., Hanson, Sheila J., Sachais, Bruce S., Hauser, Ronald George, Luban, Naomi L.C., Gottschall, Jerome, Josephson, Cassandra D., and Sola-Visner, Martha

Published
2021
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