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492 results on '"Ramkumar, V."'

11. Cangrelor in cardiogenic shock and after cardiopulmonary resuscitation: A global, multicenter, matched pair analysis with oral P2Y12 inhibition from the IABP-SHOCK II trial

Author

Droppa, Michal, Vaduganathan, Muthiah, Venkateswaran, Ramkumar V., Singh, Abhayjit, Szumita, Paul M., Roberts, Russel J., Qamar, Arman, Hack, Luis, Rath, Dominik, Gawaz, Meinrad, Fuernau, Georg, de Waha-Thiele, Suzanne, Desch, Steffen, Schneider, Steffen, Ouarrak, Taoufik, Jaffer, Farouc A., Zeymer, Uwe, Thiele, Holger, Bhatt, Deepak L., and Geisler, Tobias

Published
2019
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12. Investigation on the flow behavior and formability of AA5052 at cryogenic temperatures.

Author

Vijayakumar, M., Dineshkumar, M., Karthikeyan, S., Yuvanarasimman, P., Ramkumar, V., Raja, R. Satheesh, and Arunprasath, K.

Subjects
STRAIN rate, DISLOCATION density, ALUMINUM alloys, TENSILE tests, TENSILE strength, STRESS-strain curves
Abstract

Cryogenic forming has significant potential as a novel method for fabricating aluminum alloys, because to its improved formability. Cryogenic deformation of alloys has interesting mechanical properties, but further study is needed to fully understand them. Here, the flow performance and underlying distortion mechanism of AA5052 at cryogenic conditions were extensively analyzed. To develop and modify a constitutive model, uniaxial tensile tests were conducted between 115-299 K at strain rates of 0.00030 to 0.02 s-1. The Erichsen cupping index (IE) values were then analyzed throughout a wide temperature range (299 K, 205 K, and 115 K). A smooth stress-strain curve was achieved below 205 K because dynamic strain aging was suppressed, in contrast to the serrated curve reported between 205 K and 299 K. The alloy's elongation and IE value were approximately 53% and 21% larger, respectively, at 115 K compared to those obtained at 299 K. This was because to the elevated critical dislocation density and persistent deformation that occur at extremely low temperatures. The 31% increase in tensile strength at 115 K is due to cryogenic deformation under high dislocation density. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS‐TIMI 54 Trial

Author

Remo H. M. Furtado, Ramkumar V. Venkateswaran, Jose C. Nicolau, Yared Gurmu, Deepak L. Bhatt, Robert F. Storey, P. Gabriel Steg, Giuglia Magnani, Shinya Goto, Mikael Dellborg, Gabriel Kamensky, Daniel Isaza, Philip Aylward, Per Johanson, and Marc P. Bonaca

Subjects
arrhythmias, caffeine, cardiovascular outcomes, dyspnea, ticagrelor, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background A proposed cause of dyspnea induced by ticagrelor is an increase in adenosine blood levels. Because caffeine is an adenosine antagonist, it can potentially improve drug tolerability with regard to dyspnea. Furthermore, association between caffeine and cardiovascular events is of clinical interest. Methods and Results This prespecified analysis used data from the PEGASUS TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin–Thrombolysis in Myocardial Infarction 54) trial, which randomized 21 162 patients with prior myocardial infarction to ticagrelor 60 mg or 90 mg or matching placebo (twice daily). Baseline caffeine intake in cups per week was prospectively collected for 9694 patients. Outcomes of interest included dyspnea, major adverse cardiovascular events (ie, the composite of cardiovascular death, myocardial infarction, or stroke), and arrhythmias. Dyspnea analyses considered the pooled ticagrelor group, whereas cardiovascular outcome analyses included patients from the 3 randomized arms. After adjustment, caffeine intake, compared with no intake, was not associated with lower rates of dyspnea in patients taking ticagrelor (adjusted hazard ratio (HR), 0.91; 95% CI, 0.76–1.10; P=0.34). There was no excess risk with caffeine for major adverse cardiovascular events (adjusted HR, 0.78; 95% CI, 0.63–0.98; P=0.031), sudden cardiac death (adjusted HR, 0.98; 95% CI, 0.57–1.70; P=0.95), or atrial fibrillation (adjusted odds ratio, 1.07; 95% CI, 0.56–2.04; P=0.84). Conclusions In patients taking ticagrelor for secondary prevention after myocardial infarction, caffeine intake at baseline was not associated with lower rates of dyspnea compared with no intake. Otherwise, caffeine appeared to be safe in this population, with no apparent increase in atherothrombotic events or clinically significant arrhythmias. Registration URL: https://www.clini​caltr​ials.gov; Unique identifier: NCT01225562.

Published
2020
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22. Identification of Racial Inequities in Access to Specialized Inpatient Heart Failure Care at an Academic Medical Center

Author

Eberly, Lauren A., Richterman, Aaron, Beckett, Anne G., Wispelwey, Bram, Marsh, Regan H., Cleveland Manchanda, Emily C., Chang, Cindy Y., Glynn, Robert J., Brooks, Katherine C., Boxer, Robert, Kakoza, Rose, Goldsmith, Jennifer, Loscalzo, Joseph, Morse, Michelle, Lewis, Eldrin F., Abel, Samantha, Adams, Ayrenne, Anaya, Joseph, Andrews, Erik H, Atkinson, Benjamin, Avutu, Viswatej, Bachorik, Alexandra, Badri, Omar, Bailey, Mariel, Baird, Katie, Bakshi, Salina, Balaban, Denis, Barshop, Kenneth, Baumrin, Emily, Bayomy, Omar, Beamesderfer, Julia, Becker, Nora, Berg, David D., Berman, Adam N., Blum, Steven M., Boardman, Alexander P., Boden, Kaeleen, Bonacci, Robert A, Brown, Sarah, Campbell, Kirsti, Case, Siobhan, Cetrone, Emily, Charrow, Alexandra, Chiang, David, Clark, Devin, Cohen, Aaron J., Cooper, Alissa, Cordova, Tomas, Cuneo, C. Nicholas, de Feria, Alsina Alejandro, Deffenbacher, Karen, DeFilippis, Ersilia M., DeGregorio, Geneva, Deutsch, Aaron J., Diephuis, Bradford, Divakaran, Sanjay, Dorschner, Peter, Downing, Nicholas, Drescher, Caitlin, D’Silva, Kristin M., Dunbar, Peter, Duong, David, Earp, Sarah, Eckhardt, Christine, Elman, Scott A., England, Ross, Everett, Kay, Fedotova, Natalie, Feingold-Link, Tamara, Ferreira, Mark, Fisher, Herrick, Foo, Patricia, Foote, Michael, Franco, Idalid, Gilliland, Thomas, Greb, Jacqueline, Greco, Katherine, Grewal, Sungat, Grin, Benjamin, Growdon, Matthew E., Guercio, Brendan, Hahn, Cynthia K., Hasselfeld, Brian, Haydu, Erika J, Hermes, Zachary, Hildick-Smith, Gordon, Holcomb, Zachary, Holroyd, Kathryn, Horton, Laura, Huang, George, Jablonski, Stanley, Jacobs, Douglas, Jain, Nina, Japa, Sohan, Joseph, Richard, Kalashnikova, Mariya, Kalwani, Neil, Kang, Daniel, Karan, Abraar, Katz, Joel T, Kellner, Daniel, Kidia, Khameer, Kim, June-Ho, Knowles, Scott M, Kolbe, Laura, Kore, Idil, Koullias, Yiannis, Kuye, Ifedayo, Lang, Joshua, Lawlor, Matthew, Lechner, Melissa G., Lee, Ken, Lee, Scott, Lee, Zachary, Limaye, Neha, Lin-Beckford, Stephanie, Lipsyc, Marla, Little, Jessica, Loewenthal, Julia, Logaraj, Ranjani, Lopez, Diana M, Loriaux, Daniel, Lu, Yi, Ma, Kevin, Marukian, Nareh, Matias, Wilfredo, Mayers, Jared R., McConnell, Ian, McLaughlin, Michael, Meade, Christina, Meador, Catherine, Mehta, Anish, Messenger, Elizabeth, Michaelidis, Constantinos, Mirsky, Jacob, Mitten, Emilie, Mueller, Alisa, Mullur, Jyotsna, Munir, Amir, Murphy, Emily, Nagami, Ellen, Natarajan, Abirami, Nsahlai, Michelle, Nze, Chijioke, Okwara, Noreen, Olds, Peter, Paez, Rafael, Pardo, Michael, Patel, Siddharth, Petersen, Alec, Phelan, Laura, Pimenta, Erica, Pipilas, Daniel, Plovanich, Molly, Pong, Denise, Powers, Brian W., Rao, Anita, Ramirez Batlle, Haiyan, Ramsis, Mattheus, Reichardt, Anna, Reiger, Sheridan, Rengarajan, Michelle, Rico, Stephanie, Rome, Benjamin N., Rosales, Rachael, Rotenstein, Lisa, Roy, Alexis, Royston, Sarah, Rozansky, Hallie, Rudder, Meghan, Ryan, Christine E., Salgado, Sanjay, Sanchez, Pablo, Schulte, Jennifer, Sekar, Aswin, Semenkovich, Nicholas, Shannon, Evan, Shaw, Neil, Shorten, Andrew Ben, Shrauner, William, Sinnenberg, Lauren, Smithy, James W., Snyder, Gregory, Sreekrishnan, Anirudh, Stabenau, Hans, Stavrou, Eleni, Stergachis, Andrew, Stern, Robert, Stone, Alexander, Tabrizi, Shervin, Tanyos, Sam, Thomas, Cristina, Thun, Haley, Torres-Lockhart, Kristine, Tran, An, Treasure, Carolyn, Tsai, Frederick D., Tsaur, Stephen, Tschirhart, Evan, Tuwatananurak, Justin, Venkateswaran, Ramkumar V., Vishnevetsky, Anastasia, Wahl, Lindsay, Wall, April, Wallace, Frances, Walsh, Elisa, Wang, Priscilla, Ward, Heather B., Warner, Lindsay N., Weeks, Lachelle D., Weiskopf, Kipp, Wengrod, Jordan, Williams, Jessica N., Winkler, Marisa, Wong, Jeffrey L., Worster, Devin, Wright, Aileen, Wunsch, Caroline, Wynter, Jamila S., Yarbrough, Chase, Yau, Wai-Ying, Yazdi, Daniel, Yeh, Jennifer, Yialamas, Maria A., Yozamp, Nicholas, Zambrotta, Marina, and Zon, Rebecca

Published
2019
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37. Effect of intrathecal dexmedetomidine versus intravenous dexmedetomidine on subarachnoid anesthesia with hyperbaric bupivacaine

Author

Anshu Sharma, Nita Varghese, and Ramkumar V. Venkateswaran

Subjects
Hyperbaric bupivacaine, Sedation, lcsh:RS1-441, subarachnoid, anesthesia, Intrathecal, Group B, lcsh:RD78.3-87.3, lcsh:Pharmacy and materia medica, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, medicine, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, Dexmedetomidine, Bupivacaine, business.industry, dexmedetomidine, 030208 emergency & critical care medicine, Blockade, Anesthesiology and Pain Medicine, lcsh:Anesthesiology, Anesthesia, Original Article, Analysis of variance, medicine.symptom, business, medicine.drug
Abstract

Background and Aim: Alpha-2 agonists such as dexmedetomidine when given intravenously or intrathecally as an adjuvant potentiate subarachnoid anesthesia. We studied the difference in subarachnoid anesthesia when supplemented with either intrathecal or intravenous dexmedetomidine. Material and Methods: Seventy-five patients posted for lower limb and infraumbilical procedures were enrolled for a prospective, randomized, double-blind, placebo-controlled study and divided into three groups: Group B (n = 25) received intravenous 20 mL 0.9%N aCl over 10 min followed by intrathecal 2.4 mL 0.5%bupivacaine + 0.2 mL sterile water; Group BDexIT (n = 25) received intravenous 20 mL 0.9%N aCl over 10 min followed by intrathecal 2.4 mL 0.5%b upivacaine + 0.2 mL (5 μg) dexmedetomidine; Group BDexIV (n = 25) received intravenous dexmedetomidine 1 μg/kg in 20 mL 0.9%N aCl over 10 min followed by intrathecal 2.4 mL 0.5%b upivacaine + 0.2 mL sterile water. Onset and recovery from motor and sensory blockade, and sedation score were recorded. Onset of sensory and motor blockade was assessed using Kruskal–Wallis test, whereas 2-segment regression and recovery was analyzed using ANOVA and post hoc Tukey's test to determine difference between the three groups. P value Group BDexIV > Group B (P < 0.001). Patients in Group BDexIT and Group BDexIV were sedated but easily arousable. Conclusion: Intrathecal dexmedetomidine prolongs the effect of subarachnoid anesthesia with arousable sedation when compared with intravenous dexmedetomidine.

Published
2020

38. Space cloud in cubesat - Consigning expert system to space.

Author

Aravindaguru, I., Arulselvam, D., Kanagavalli, N., Ramkumar, V., and Karthick, R.

Subjects
CUBESATS (Artificial satellites), MICROSPACECRAFT, SPACE exploration, ASTRONAUTICS, ARTIFICIAL intelligence, EXPERT systems
Abstract

The world gets incalculably benefitted from Space Technology in terms of Communication, Positioning, Observation, Detection. The advancement of technology and the commencement of very small satellites starting from Microsatellites, Nanosatellites, Picosatellites, Femtosatellites have meant that startle large Multinational companies and emerging countries that could reach space in an accessible way with a short span of time in a position to compete the targeted destination. The most innovative and interesting sector in space is "CubeSat" that are being used in several applications such as Remote Sensing, Earth Observation, Asset Tracking, Security, defence, IoT & Communications, Humanitarian aid, etc., Exploration of the Universe has been one of the fundamental human instincts. Though Space Explorations began with man's quest for knowledge, the technologies that were developed in the process have found applications that are of direct relevance to the development of society. Today Space-based telecommunications, TV Broadcasting, Metrology, Resource Monitoring have become much more pivotal and seminal in everyday life. This demographical statistic proves and shows the reason and their consideration for the rapid accretion towards Minisatellites especially CubeSats. The Collection, Procession, and the distribution of the meaningful data and information, wherein bringing up the Cloud Computing Service allied with Artificial Intelligence in CubeSats. [ABSTRACT FROM AUTHOR]

Published
2022
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39. An efficient iot based healthcare data management and transfer using blockchain technology.

Author

Veeramani, P., Rajasekar, P., Ramkumar, V., Azhagumurugan, R., Basha, Shaik Althaf Hussain, and Bharathy, A. Santham

Subjects
DATABASE management, TECHNOLOGICAL progress, INTERNET of things, TECHNOLOGICAL innovations, DATA security, BLOCKCHAINS, TECHNOLOGY transfer, PROFESSIONAL-client communication
Abstract

In recent times, technological advancements have resulted in dramatic change in the health sector. The Internet of Things, Cloud Computing, Block chain, lab-on-a-chip, non-invasive and percutaneous operations, and other innovations have made treating a variety of ailments much easier. Both research and the healthcare business have benefited greatly from these emerging innovations. Miniaturized healthcare sensors driven by IoT can be used for clinical tests and self-health tracking. They assist professionals in remote regions who weren't in direct communication with clients with immediate diagnostic and treatment recommendations. Controlling access mechanisms and uneven security policies were a hurdle in meeting the security standards of these data. A blockchain-based intelligent contract and an enterprise-distributed record architecture can be used to track the patient's condition. This permits patients' medical information, and an irreversible and lengthy history log, to be retrieved worldwide at whatever time. The suggested system gives greater monitoring, increased connectivity, and higher data security if compared to standard patient monitoring devices. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Spontaneous, homeostatic, and inflammation-induced sleep in NF-[kappa]B p50 knockout mice

Author

Jhaveri, K.A., Ramkumar, V., Trammell, R.A., and Toth, L.A.

Subjects
Polysaccharides -- Research, Sleep -- Physiological aspects, Biological sciences
Abstract

The dimeric transcription factor nuclear factor-[kappa]B (NF-[kappa]B) regulates several endogenous sleep-modulatory substances and thereby serves as a pivotal mediator of sleep-wake homeostasis. To further define the role of NF-[kappa]B in sleep regulation, we monitored sleep and temperature in mice that lack the p50 subunit of NF-[kappa]B [p50 knockout (KO) mice]. Compared with the control B6129PF2/J strain, p50 KO mice spend more time in slow-wave sleep (SWS) and rapid eye movement sleep (REMS) under normal conditions and show enhanced homeostatic recovery of sleep after sleep loss. p50 KO mice also show increased SWS and reduced REMS and temperature after the administration of lipopolysaccharide, yet they are behaviorally less responsive to challenge with influenza virus. These data support a role for NF-[kappa]B, and, in particular, for the p50 subunit, in the regulation of sleep in healthy mice and in mice experiencing immune challenge. nuclear factor-[kappa]B; p50 knockout mice; sleep; temperature; lipopolysaccharide; influenza

Published
2006

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