59 results on '"Ramesh Kumar Sharma"'
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2. Exploring the efficacy of a novel prebiotic-like growth promoter on broiler chicken production performance
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Zulfqarul Haq, Ankur Rastogi, Ramesh Kumar Sharma, Pratiksha Raghuwanshi, Maninder Singh, Azmat Alam Khan, and Syed Mudasir Ahmad
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Novel growth promoter ,Antibiotics ,Chicken ,Antimicrobial resistance ,Prebiotic ,Veterinary medicine ,SF600-1100 - Abstract
This study attempts to isolate a candidate growth promoter from the ovine paunch waste and scrutinize its effects on the production performance of broiler chickens as compared to mannan-oligosaccharide (MOS), a prebiotic, and lincomycin, an antibiotic growth promoter (AB). The paunch waste collected from slaughtered sheep was processed to remove particulate matter. The clarified liquid was then added to an excess of ethanol (1:9 ratio), and the resultant precipitate {(novel growth-promoting paunch extract (NGPE)} was collected, dried, and stored. In vitro increase in cell density for probiotic bacteria viz. Lactobacillus rhamnosus and Enterococcus faecalis (Log10 CFU/ml) were significantly higher (P
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- 2024
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3. Evaluation of native medicinal plants as feed additives in the Sheep ration
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DILSHAD KOUR, VIJAY KUMAR SHARMA, RAMESH KUMAR SHARMA, ANAND KUMAR PATHAK, and ANKUR RASTOGI
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Feed additives, Herbs, Pimpinella anisum ,Animal culture ,SF1-1100 - Abstract
The present study evaluated nutritional attributes of local medicinal herbs and analysed their effect as feed additives in sheep ration. Proximate and fiber analysis of all herbs- Allium sativa, Cuminum cyminum, Emblica officinalis, Murraya koenigiii, Pimpinella anisum, Sapindus trifoliatus, Terminalia arjuna, Trigonella-foenum graecum, Zingiber officinale, Curcuma longa, Ocimum tenuiflorum and Azadirachta indica and their further screening at different inclusion levels of 3%, 3.5% and 4% of ration to ascertain their effect on in vitro rumen fluid pH, dry matter digestibility and organic matter digestibility of ration was carried out during in vitro phase. Pimpinella anisum @ 3% of ration resulted in significant increase in in vitro dry matter digestibility and in vitro organic matter digestibility of ration. In vivo trial was conducted in which fourteen indigenous, non-descript, adult male sheep (body weight, 27.10±0.10 kg and age, 22-24 months) were randomly allotted into two groups and fed ad lib. wheat straw and concentrate mixture @ 25 g/W0.75 along with Pimpinella anisum @ 3% of ration in treatment group. Comparable OM, CP, EE digestibility was seen in both groups, however, treatment group had significantly higher DM, total carbohydrate, CF, NDF, ADF and HC digestibility. Both groups had positive nitrogen, calcium and phosphorus balance, however, treatment group had significantly increased nitrogen balance. Rumen fermentation parameters were comparable in both groups. Haemoglobin, PCV, serum protein and albumin in treatment group were significantly higher while no significant variation was seen in serum globulin, Albumin:Globulin ratio, total cholesterol, ALT, AST, BUN, creatinine and blood glucose concentration between both groups. It can be inferred from the above data that Pimpinella anisum @ 3% of ration can effectively be used as a feed additive in sheep ration for improving feed intake, nutrient digestibility and utilisation.
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- 2023
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4. Congenital palatal fistula: Case report and review of literature
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Sneha Gulati, Aditya Shivaji Yadav, and Ramesh Kumar Sharma
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congenital palatal fistula ,hard palate ,palatal muscles ,palatoplasty ,soft palate ,submucous palate ,Dentistry ,RK1-715 ,Surgery ,RD1-811 - Abstract
Congenital palatal fistula (CPF) is the rarest phenotypic variation of cleft palate, commonly associated with submucous cleft palate (SCP). Isolated palatal fistula without SCP has been reported only rarely. We report here the case of a 4-year-old child, with a 10 mm × 5 mm CPF, presenting with nasal regurgitation and speech abnormalities. The patient had unilateral palatal muscular malposition without classical features of SCP. The repair was performed using turnover flaps and Bardach's two-long flap palatoplasty and intravelar veloplasty. Healing occurred without any complications.
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- 2023
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5. Comparison of blood loss at the donor site & Acute cardiovascular effects by using adrenaline infiltration and topical adrenaline during skin graft harvest
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Chethan L., Harish Kumar, Ramesh Kumar Sharma, and Sandhya Yaddanapudi
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blood loss ,heart rate ,blood pressure ,donor site ,topical adrenaline ,adrenaline infiltration ,Medicine - Abstract
Background. Burn surgery is associated with high blood loss to both the donor and recipient site. Although various techniques for reducing intraoperative blood loss have been described, topical adrenaline and adrenaline infiltration have significantly reduced blood loss. The present study compared blood loss to the donor site and acute cardiovascular effects (such as heart rate/ HR and blood pressure/ BP), by using adrenaline infiltration and topical adrenaline while harvesting the skin graft in the same patient, but in a different place. Materials and Methods. It is a prospective study that included 50 patients, all undergoing skin graft harvesting using method 1 and local adrenaline - method 2, in different locations. Blood loss and acute cardiovascular effects were assessed and compared between two methods. Results. Blood loss at the donor site is significantly lower in adrenaline infiltration compared to topical infiltration (4.7±0.6 ml vs 10.4±1.2 ml, p
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- 2022
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6. The Impact of 'COVID-19' and 'Webinar Pandemic' on Plastic Surgery Practice in Teaching Institutes and Resident Training—A Multicentric Perspective
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Satyaswarup Tripathy, Devi Prasad Mohapatra, Ranjit Kumar Sahu, Subair Mohsina, Ramesh Kumar Sharma, Subhendu Khan, Sharda Renu, Chandra Kunwari Singh, Suraj R. Nair, Shijina Koliath, and Imran Pathan
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hand trauma ,faciomaxillary injury ,malignancy reconstruction ,aesthetic procedures ,webinar ,conferences ,Surgery ,RD1-811 - Abstract
Introduction The study was carried out to quantify the changes induced by the pandemic in plastic surgery practice and training and to study the impact of the webinars on plastic surgery education from a residents’ perspective. Methods In this multicentric study, the number and type of surgeries, cause of injuries, and their regional variation during the coronavirus disease 2019 (COVID-19) period (February–September 2020) were compared with pre–COVID-19 time. An online survey on the impact of webinars was conducted for plastic surgery trainees across the country. Results There was a significant reduction in total number of surgeries (p = 0.003). The procedures for hand (p = 0.156), faciomaxillary injuries (p = 0.25), and replantations (p = 0.46) were comparable; there was a significant reduction in combined orthopedic-plastic-surgical procedures (p = 0.009) during the pandemic. There was a significant reduction in road accidents (p = 0.007) and suicidal injuries (p = 0.002) and increase in assault (p = 0.03) and domestic accidents (p = 0.01) during the COVID-19 period. A usefulness score of >8 was given for the webinars by 68.7% residents. There was no significant difference in perception of utility when correlated with the academic program at their institutes (p = 0.109); 92% opined webinars should continue in post-COVID times. Conclusion There was a drastic reduction in number of elective and emergency procedures during the COVID-19 time, negatively affecting resident training program. Majority of residents felt that webinars could prove a useful adjunct to training in formal training program in post-COVID-19 scenario.
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- 2022
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7. An Innovative Skin Simulation Model to Augment Competency-based Training in Facial Plastic Surgery
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Satyaswarup Tripathy, Devi Prasad Mohapatra, Friji Meethale Thiruvoth, Ramesh Kumar Sharma, Likhitha Reddy, and Neljo Thomas
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residents training ,cbme ,facial plastic surgery ,flaps ,surgical simulation ,Surgery ,RD1-811 - Abstract
Introduction Competency-based medical education (CBME) approach in the medical curriculum has been introduced globally with the goal of providing flexibility, accountability, and learner-centeredness among medical learners. Traditional surgical skill training in most places has relied on “see one, do one, teach one model,” while simulation model-based training has been shown to improve competencies in surgical trainees. We wanted to assess the usefulness of a hydrophilic barrier adhesive foam wound dressing as a novel skin simulation model for learning biomechanics and practice of cutaneous flaps among plastic surgical resident trainees at our institute. Materials and Methods An absorbent, soft polyurethane foam pad located centrally upon a larger polyurethane membrane, coated with a hydrocolloid adhesive, forming an island dressing, was used as a simulation model for this study. It was obtained from the hospital store either after or nearing their expiry dates of clinical use. Plastic surgery residents in different years of training were invited to participate in a simulation workshop, using this novel model, and give their feedback. Results Seventeen residents in different plastic surgery training levels participated in the workshop and gave their feedback on the skin flap simulation model. The simulation model received extremely high (100%) scores on two parameters, namely, utility for flap and suture practice and high scores (88%–94%) for texture, ability to mark, and improving confidence among trainees. Conclusions Adhesive bilayer polyurethane foam can be used as a novel cutaneous skin flap simulation model for understanding the biomechanics of skin flaps and cutaneous flap practice.
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- 2022
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8. Clinical Outcomes of Surgical Management of Primary Brachial Plexus Tumors
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Sunil Gaba, Subair Mohsina, Jerry R. John, Satyaswarup Tripathy, and Ramesh Kumar Sharma
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schwannoma ,neurofibroma ,microneurolysis ,paresthesia ,dumbbell tumor ,Surgery ,RD1-811 - Abstract
Introduction This study evaluates the clinical presentation, tumor characteristics, and clinical outcomes of surgically treated benign and malignant brachial plexus tumors (BPTs). Methods A prospective study of patients with BPTs from June 2015 to August 2020 was conducted. All patients underwent surgical resection with microneurolysis and intraoperative electrical stimulation to preserve the functioning nerve fascicles. Results Fourteen patients with 15 BPTs underwent surgical resection. Mean age was 37.8 ± 12.3 years; with male to female ratio 4:10. The clinical presentations were swelling (100%), pain (84.6%), and paresthesia (76.9%). The lesions involved roots (5/15), trunk (5/15), division (1/15), and cords (4/15). Thirteen patients had benign pathology (8 schwannomas, 3 neurofibromas, 2 lipomas) and two had malignant neurofibrosarcoma. Gross total resection was achieved in all cases except a dumbbell tumor. The mean follow-up period was 24 ± 5 months. Postoperatively, all patients reported improvement in pain and paresthesia with no new sensory deficit. All patients had developed initial motor weakness (Grades 2–4); however, full power (Grade 5) was recovered by 3 to 5 months. Conclusion Total resection can be achieved by appropriate microneural dissection and electrophysiologic monitoring and is potentially curative with preserving function.
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- 2021
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9. Triangular flap technique for unilateral cleft lip deformity
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Ramesh Kumar Sharma
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cleft lip ,complete and incomplete ,repair ,triangular flap technique ,Dentistry ,RK1-715 ,Surgery ,RD1-811 - Abstract
The triangular flap lip repair is one of the two main techniques used for the correction of a cleft lip deformity worldwide. Many surgeons in Indian subcontinent and Europe use the triangle flap technique as their first choice. This CME article describes the details of the triangular flap technique as modified by Dr. C P Sawhney. The rationale of the technique, lip markings, planning of incisions, and the detailed operative steps are described. The merits and demerits of this versatile technique are also discussed.
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- 2021
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10. Distraction Lengthening of First Metacarpal in Traumatic Thumb Amputations
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Abid Saleem, Ramesh Kumar Sharma, and Parmod Kumar
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thumb amputation ,distraction ,callotasis ,phalangization ,pollicization ,Surgery ,RD1-811 - Abstract
Introduction Based on the level of the thumb loss, phalangization, toe-to-thumb transfer, pollicization, and distraction callotasis of the first metacarpal are the various options available for reconstruction. The aims of the study were to observe the length gained in the distraction process, duration of treatment required, functional recovery in the form of pinch strength, sensations, and patient satisfaction. Patients and Methods It was a prospective study of 10 patients of thumb amputation, conducted from January 2014 to July 2015. The patients’ age, mode of injury, level of amputation, and advantages and disadvantages of distraction callotasis were evaluated. Results The most common etiology of thumb loss was domestic accidents while working with a chaff cutter. The total duration of treatment was 124 (93–165) days and the mean gain in length was 25 (20–28) mm. The pinch strength increased from a mean of 0.91 to 2.06 kg, i.e., a 44.17% improvement from preoperative pinch strength. All of our patients retained their sensations of the reconstructed thumb post distraction. Conclusions Among many options for thumb reconstruction, distraction callotasis is a simple and safer option in the selective group of patients who are not keen on toe-to-thumb transfer which provide a significant improvement. The longer duration of treatment is the disadvantage associated with the need for proper counselling beforehand.
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- 2019
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11. Columellar strut graft in unilateral cleft nasal deformity: Anthropometry and clinical outcomes
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Kumar Prasad Preetha Rani, Atul Parashar, and Ramesh Kumar Sharma
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columellar strut graft ,tip projection ,unilateral cleft nasal deformity ,Dentistry ,RK1-715 ,Surgery ,RD1-811 - Abstract
Introduction: The cleft nasal deformity is a three-dimensional asymmetry involving all layers of the nose. Columellar strut graft is an important method to provide support to the skeletal framework in an attempt to retain structural support and balance. Aims: The purpose of our study is to describe the surgical outcomes following the use of columellar strut graft when it is used in secondary cleft rhinoplasty. The study was designed to identify the changes in tip projection (Tip Proj), tip rotation (Tip Rot), and other anthropometric measurements postoperatively. Materials and Methods: A prospective study was conducted among patients presenting with secondary cleft nasal deformity and operated utilizing a columellar strut graft. The parameters considered were columellar height (CH), columellar width, Tip Proj, Tip Rot, nasofrontal angle, nasofacial angle, and nasolabial angle. All the measurements were analyzed statistically. Results: During the study, results could be evaluated for 25 patients. The Tip Proj increased in 84% of patients, and the magnitude of difference between pre- and post-operative follow-up at 9 months was found to be statistically significant (P = 0.009). The CH increased in 20 patients (80%). The Tip Rot increased in 20 patients (80%). The postoperative changes were consistently maintained at different follow-up intervals. Conclusions: Columellar strut is necessary in improving the Tip Proj, correcting the tilted tripod and lower lateral cartilage deformities. It also functions as a central scaffold on which the tip structures can be unified.
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- 2019
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12. Changing trends in plastic surgery training
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Ramesh Kumar Sharma
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course duration ,evaluation ,plastic surgery ,reconstructive and aesthetic content ,training ,Surgery ,RD1-811 - Abstract
Background: The currently available training models are being put to scrutiny in India today, both by the residents and the teachers. Plastic surgery specialty was created primarily for reconstructive purposes but the society always perceived it from a cosmetic angle, particularly in the post second world war era. As a result, there is a need to redefine the goals of plastic surgery training in the present times so that the plastic surgeon is ‘future ready’ to meet the needs of society and the market forces. Materials and Methods: The author has reviewed the currently available literature on plastic surgery training from India and the western countries. An attempt has been made to study opinions from the teachers and the trainees. The modules currently available in India and abroad have been analyzed and a suggestion has been made for drafting training programs that would meet the demands of the society as well as prepare the resident both for the aesthetic and reconstructive practice. Conclusions: The plastic surgery training needs to be more vibrant and in tune with the changing times. While maintaining its core nature, the current predominantly reconstructive modules need to incorporate the aesthetic content. The evaluation should be both knowledge and competence based. The teachers need to be educated in the various teaching methods that are more applicable to grown up residents. There is a need to find ways to attract talented people in the academic plastic surgery.
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- 2014
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13. A hybrid technique of trapezius muscle transfer for a flail shoulder in late brachial plexus injuries
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Akhil Garg, K. S. Ajai, Satyaswarup Tripathy, Nirmal Raj Gopinathan, and Ramesh Kumar Sharma
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Surgery ,RD1-811 - Published
- 2018
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14. Unfavourable results in craniofacial surgery
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Ramesh Kumar Sharma
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Complications ,craniofacial surgery ,Post-graduate Institute of Medical Education and Research Chandigarh ,unfavourable results ,Surgery ,RD1-811 - Abstract
Craniofacial surgery is one of the newer subspecialties of plastic surgery and owes its birth to the pioneering work of Paul Tessier in the late sixties. Since then this challenging specialty work has been taken up by many centres around the word including India. Initial reports in late eighties and early nineties showed morbidity and mortality ranging from 1.6% to 4.3%. However over past few decades, with improved instrumentations, safer anaesthesia and cumulative experience of surgeons the morbidity and mortality has been brought down to as low as 0.1% in many centres in USA. In our centre at Post-graduate Institute, Chandigarh, the mortality rate is about 0.8% (4 out of 480 cases). The learning curve in this surgery is rather steep but with experience and a well-coordinated team work, results in this complex subspecialty can be improved. The infection is a major cause for worry but can be easily prevented by sound surgical principles and placing a vascularised tissue barrier between the extradural space and the nasopharynx/sinus mucosa.
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- 2013
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15. Craniosynostosis
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Ramesh Kumar Sharma
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Abnormal skull shapes ,cosmetic and functional issues ,cranioplasty ,fronto-orbital advancement ,premature suture fusion ,Surgery ,RD1-811 - Abstract
Craniosynostosis is a premature pathologic fusion of one or more cranial vault sutures that leads to abnormal shape of the skull. The fused sutures lead to restricted growth in some areas and compensatory bossing in other areas. The head may assume different shapes depending upon the site and timing of the abnormally fused suture. The exact cause of this suture pathology is still unknown, but the local dura, cranial base and the fibroblast growth factors seem to influence this. The diagnosis rests on clinical examination and confirmation is generally on the computed tomography scan. The need for surgery is both for cosmetic and functional reasons. Many cases may be associated with raised intracranial pressure with its attendant deleterious effects on vision and brain. The aim of treatment is to increase the cranial volume and reshape the skull. The surgery can be safely undertaken around 9-12 months in most of the cases. The conventional management is through an open surgical approach; although, some centres have claimed impressive results with limited endoscopic techniques in selected cases. The review article deals with the aetiopathogenesis, clinical presentations and management of the common varieties of craniosynostoses seen in the Indian scenario.
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- 2013
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16. Protocol of an observational study to evaluate diabetic nephropathy through detection of microalbuminuria in Indian patients
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Gokulnath, Manisha Sahay, Sanjay Kalra, Vijay Vishwanathan, Abdul Hamid Zargar, Pradeep G Talwalkar, Subhash Kumar Wangnoo, Debasish Maji, G Vijay Kumar, Ramesh Kumar Sharma, Deodatta Chafekar, Brij Mohan, Ganapathi Bantwal, Anil Bansali, and Jasmeet Singh Sahni
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Diabetic nephropathy ,dipstick test ,health policy ,India ,microalbuminuria ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Aim: To assess the prevalence of persistent microalbuminuria (MAU), its clinical correlates by dip stick method, its predictive value for potential kidney disease and the utility of this test as objective cue for health care seeking behavior in adult Indian patients with type 2 diabetes mellitus. Materials and Methods: Approximately 400,000 patients shall be enrolled in this multicentric, cross sectional study. Patients meeting eligibility criteria shall be screened for MAU through urine dipstick test using random daytime single spot urine specimen. Result shall be expressed either positive or negative based on the presence or absence of albumin in the urine and will be correlated with the corresponding random blood glucose. Height, weight, waist circumference and blood pressure shall be assessed. There will be three visits with a minimum interval of 28 days between two visits, to be completed within 180 days, and at least two of three urine tests measured in this period must show elevated albumin levels to diagnose MAU. Conclusion: Detection of MAU through the dipstick method is postulated to be a rapid, reliable test for early detection of diabetic nephropathy, which, in turn will help the physician to plan treatment strategy. Further, it will help to identify the disease burden on the individual and society, and may serve as an objective cue for improved health care seeking behavior, as well as a catalyst for health policy change.
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- 2013
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17. Unfavourable outcomes in maxillofacial injuries: How to avoid and manage
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Atul Parashar and Ramesh Kumar Sharma
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Craniofacial skeleton ,faciomaxillary injuries ,fracture ,post-traumatic deformity ,Surgery ,RD1-811 - Abstract
Faciomaxillary injuries remain one of the common injuries managed by plastic surgeons. The goal of treatment in these injuries is the three-dimensional restoration of the disturbed anatomy so as to achieve pre-injury form and function. In this article, the authors review the anatomic, diagnostic and management considerations to optimise results and minimise the late post-traumatic deformities. Most of the adverse outcomes are usually a result of poorly addressed underlying structural injury during the primary management. An accurate physical examination combined with detailed computed tomographic scanning of the craniofacial skeleton is required to generate an appropriate treatment plan. This organised approach has proven effective in restoring the injured structures to pre-injury status. Multiple clinical cases are used to illustrate the different fracture patterns along with various surgical techniques to achieve an acceptable outcome. Early diagnosis and timely management of complications in these complex injuries is also discussed.
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- 2013
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18. A novel method to insert drain atraumatically after liposuction in gynaecomastia
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Sunil Gaba, K. S. Ajai, Ramesh Kumar Sharma, and L. Chetan
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Surgery ,RD1-811 - Published
- 2018
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19. Role of stem cells in the management of chronic wounds
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Ramesh Kumar Sharma and Jerry R. John
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adult stem cells ,chronic wound ,stem cells ,Surgery ,RD1-811 - Abstract
Chronic wounds continue to be a major challenge for the medical profession, and plastic surgeons are frequently called in to help in the management of such wounds. Apart from the obvious morbidity to the patient, these problem wounds can be a major drain on the already scarce hospital resources. Sometimes, these chronic wounds can be more taxing than the underlying disease itself. Although many newer methods are available to handle such situations, the role of stem cells in the management of such wounds is an exciting area that needs to be explored further. A review of literature has been done regarding the role of stem cells in the management of chronic wounds. The abnormal pathology in such wounds is discussed and the possible role of stem cells for optimal healing in such cases would be detailed.
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- 2012
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20. Assessment of the abdominal wall function after pedicled TRAM flap surgery for breast reconstruction: Use of modified mesh repair for the donor defect
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Chacko Cyriac, Ramesh Kumar Sharma, and Gurpreet Singh
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abdominal wall function ,patient questionnaire ,pedicled tram flap breast reconstruction ,straight and lateral curl ups ,Surgery ,RD1-811 - Abstract
Background: The pedicled TRAM flap has been a workhorse of autologous breast reconstruction for decades. However, there has been a rising concern about the abdominal wall donor site morbidity with the use of conventional TRAM flap. This has generally been cited as one of the main reasons for resorting to “abdominal wall friendly” techniques. This study has been undertaken to assess the abdominal wall function in patients with pedicled TRAM flap breast reconstruction. The entire width of the muscle and the overlying wide disk of anterior rectus sheath were harvested with the TRAM flap in all our patients and the anterior rectus sheath defect was repaired by a Proline mesh. Materials and Methods: Abdominal wall function was studied in 21 patients who underwent simultaneous primary unipedicled TRAM flap reconstruction after mastectomy for cancer. In all the patients, the abdominal wall defect was repaired using wide sheet of Proline mesh both as inlay and onlay. The assessment tools included straight and rotational curl ups and a subjective questionnaire. The abdominal wall was also examined for any asymmetry, bulge, or hernia. The minimal follow-up was 6 months postoperative. The objective results were compared with normal unoperated volunteers. Results and Conclusions: The harvesting the TRAM flap certainly results in changes to the anterior abdominal wall that can express themselves to a variable degree. A relatively high incidence of asymptomatic asymmetry of the abdomen was seen. There was total absence of hernia in our series even after a mean follow-up period of 15.5 months. A few patients were only able to partially initiate the sit up movement and suffered an important loss of strength. In most patients, synergists took over the functional movement but as the load increased, flexion and rotation performances decreased. The lack of correlation between exercise tests and the results of the questionnaire suggests that this statistically significant impairment was functionally not important. The patients encountered little or no difficulty in theis day-to-day activities. Our modification of use of a wide mesh as inlay and onlay repair minimizes the donor site morbidity. This also avoids maneuvers meant for primary closure of the rectus sheath defects, which can result in distortion of umbilicus. Therefore, in conclusion, the unipedicled TRAM flap should be regarded as a valuable option in breast reconstruction provided careful repair of the abdominal wall defect is undertaken using Proline mesh.
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- 2010
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21. The pedicled thoraco-umbilical flap: A versatile technique for upper limb coverage
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Sharad Mishra and Ramesh Kumar Sharma
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upper limb soft tissue defects ,thoraco-umbilical flap ,periumbilical perforators ,deep inferior epigastric artery ,Surgery ,RD1-811 - Abstract
Injuries to upper limb has been on the increase and is invariably associated with significant soft tissue loss requiring a flap cover. Local tissue may not be available for cover in a majority of situations, necessitating import of tissue from a distant source. We have utilized the thoraco-umbilical flap taken from the trunk for this purpose. This flap is based on the perforators of the deep inferior epigastric artery that are maximally centred on the periumbilical region. This flap was used in 83 patients. The patients were observed for at least 3 weeks and any flap or donor site complications were recorded. The patients were again followed up at 3 months interval and the donor site scar was assessed. The flaps survived in 81 patients; there was marginal flap necrosis in five patients and partial flap necrosis in two patients. None of these patients required any additional procedure for coverage. The flap is technically easy to plan, almost effortless to drape around upper limb defects, with no significant donor site morbidity and also the post operative immobilization was fairly comfortable. The thoraco-umbilical flap thus is a very useful technique for coverage of the upper limb and is recommended as a first line flap for this purpose.
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- 2009
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22. Submental tracheal intubation in oromaxillofacial surgery
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Ramesh Kumar Sharma, Puneet Tuli, Chacko Cyriac, Atul Parashar, and Surinder Makkar
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avoiding tracheostomy ,oromaxillofacial surgery ,intubation ,Surgery ,RD1-811 - Abstract
Background: oromaxillofacial surgical procedures present a unique set of problems both for the surgeon and for the anesthesist. achieving dental occlusion is one of the fundamental aims of most oromaxillofacial procedures. oral intubation precludes this surgical prerequisite of checking dental occlusion. having the tube in the field of surgery is often disturbing for the surgeon too, especially in the patient for whom skull base surgery is planned. nasotracheal intubation is usually contraindicated in the presence of nasal bone fractures seen either in isolation or as a component of le fort fractures. we utilized submental endotracheal intubation in such situations and the experience has been very satisfying.materials and methods: the technique has been used in 20 patients with maxillofacial injuries and those requiring le fort i approach with or without maxillary swing for skull base tumors. initial oral intubation is done with a flexo-metallic tube. a small 1.5 cm incision is given in the submental region and a blunt tunnel is created in the floor of the mouth staying close to the lingual surface of mandible and a small opening is made in the mucosa. the tracheal end of tube is stabilized with magil′s forceps, and the proximal end is brought out through submental incision by using a blunt hemostat taking care not to injure the pilot balloon. at the end of procedure extubation is done through submental location only.results: the technique of submental intubation was used in a series of twenty patients from january 2005 to date. there were fifteen male patients and five female patients with a mean age of twenty seven years (range 10 to 52). seven patients had le fort i osteotomy as part of the approach for skull base surgery. twelve patients had midfacial fractures at the le fort ii level, of which 8 patients in addition had naso-ethomoidal fractures and 10 patients an associated fracture mandible. twelve patients were extubated in the theatre. eight patients had delayed extubation in the post-operative ward between 1 and 3 days postoperatively.conclusion: in conclusion, the submental intubation technique has proved to be a simple solution for many a difficult problem one would encounter during oromaxillofacial surgical procedures. it provides a safe and reliable route for the endotracheal tube during intubation while staying clear of the surgical field and permitting the checking of the dental occlusion, all without causing any significant morbidity for the patient. its usefulness both in the emergency setting and for elective procedures has been proved. the simplicity of the technique with no specialized equipment or technical expertise required makes it especially advantageous. this technique therefore, when used in appropriate cases, allows both the surgeon and the anesthetist deliver a better quality of patient care.
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- 2008
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23. Perforator plus flap: Evolution of the concept and its place in plastic surgeons repertoire
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Ramesh Kumar Sharma
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Surgery ,RD1-811 - Published
- 2010
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24. An alternative receptacle for fat harvest: The infant mucous sucker
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Satyaswarup Tripathy, Saurabh Rawat, Jerry R. John, and Ramesh Kumar Sharma
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Surgery ,RD1-811 - Published
- 2016
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25. The Scope of Craniofacial Surgery
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Ian T. Jackson and Ramesh Kumar Sharma
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Surgery ,RD1-811 - Published
- 1994
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26. Special considerations in paediatric burn patients
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Ramesh Kumar Sharma and Atul Parashar
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burn injuries ,paediatric ,special considerations ,Surgery ,RD1-811 - Abstract
Burn injuries are a major cause of morbidity and mortality in children. In India, the figure constitutes about one-fourth of the total burn accidents. The management of paediatric burns can be a major challenge for the treating unit. One has to keep in mind that “children are not merely small adults”; there are certain features in this age group that warrant special attention. The peculiarities in the physiology of fluid and electrolyte handling, the uniqueness of the energy requirement and the differences in the various body proportions in children dictate that the paediatric burn management should be taken with a different perspective than for adults. This review article would deal with the special situations that need to be addressed while treating this special class of thermal injuries. We must ensure that not only the children survive the initial injury, but also the morbidity and complications are minimized. If special care is taken during the initial management of paediatric burn injuries, these children can be effectively integrated into the society as very useful and productive members.
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- 2010
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27. Problems of middle ear and hearing in cleft children
- Author
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Ramesh Kumar Sharma and Vipul Nanda
- Subjects
cleft lip and palate ,hearing loss ,middle ear infection ,Surgery ,RD1-811 - Abstract
The hearing loss in a cleft patient is a well known complication, but generally gets ignored. These children continue to have recurrent otitis media with effusion that affects the hearing abilities. Unfortunatley the middle ear function may not improve with palatoplasty. Cleft palate teams need to follow up all such children beginning at birth and going into adulthood, decades after a ‘successful’ palate repair. These patients should have careful otological and audiological surveillance with appropriate interventions whenever required. The review article discusses the current status of hearing management in patients with cleft palate.
- Published
- 2009
- Full Text
- View/download PDF
28. Use of HDPE implants in facial skeletal augmentation: Should we rush for it?
- Author
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Ramesh Kumar Sharma
- Subjects
Surgery ,RD1-811 - Published
- 2010
- Full Text
- View/download PDF
29. Adversity: A great teacher
- Author
-
Ramesh Kumar Sharma
- Subjects
Surgery ,RD1-811 - Published
- 2013
- Full Text
- View/download PDF
30. CAN MEDIA LITERACY HELP FIGHT THE INFODEMIC? A STUDY OF YOUTH
- Author
-
Ms. Priyanka Sachdeva, Dr. Durgesh Tripathi, Dr. Ramesh Kumar Sharma, and Ms. Surbhi Tandon
- Subjects
Infodemic, Media Literacy, democratic country, social media, COVID-19 - Abstract
COVID-19 a worldwide catastrophe, and while humankind is grappling to find a solution. The pandemic has adversely affected the citizens globally both physically and psychologically, and the torrent of information is acting as a double whammy. The past research delineates that media literacy's paucity is missing in Youth, which involves critical thinking skills, analyzing and evaluating media messages. Media Literacy is emerging as a critical challenge amongst the citizens. The interdisciplinary nature of media literacy sets a foundation for understanding and participating in the public good's ongoing dialogue. In COVID-19 times, where there are restrictions on many activities and services, the research portrays that the social media usage among people has amplified to an extraordinary rate. In isolation, people are more dependent on online information. The plethora of information available online is fake and misleading, termed as ‘Infodemic’. This kind of information is risky and poses harmful effects. The most vulnerable to such a risk are Youth, as they are heedless of the adverse effects and deprive the skills of identifying the reliability and credibility of the news story. The present study with exploratory cum descriptive design attempts to determine whether the Youth are media literate or not and how they make distinctions among fake and reliable news. It also finds out that how information sharing and consumption has changed due to the pandemic. The survey method finds that people are more dependent on social media networks for news and other information. The Youth do encounter fake news and feels that it creates confusion among people. The Media Literacy skills were tested with the help of a five-point Likert scale. The findings reveal that the Youth lacks media literacy skills, and it should be taught in schools and colleges to churn out informed citizenry. The study concludes that social media platforms with the power of engaging and informing the citizens when used mindfully and with a developed knowledge structure can make wonders in a democratic country like India
- Published
- 2022
- Full Text
- View/download PDF
31. No Traces of SARS-CoV-2 In Wounds of COVID-19 Positive Patients: A Pilot Study
- Author
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Kapil Goyal, Poonam Chauhan, Vikas Suri, Shyam Charan Meena, Ankur Bhatnagar, Ramesh Kumar Sharma, Mini P Singh, Gowtham Kampalli, and Sunil Gaba
- Subjects
2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,rrt-pcr ,wound swab ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,lcsh:Surgery ,030230 surgery ,Virus ,law.invention ,03 medical and health sciences ,sars-cov-2 virus ,0302 clinical medicine ,law ,Medicine ,Special Topic ,Polymerase chain reaction ,integumentary system ,business.industry ,030208 emergency & critical care medicine ,lcsh:RD1-811 ,Virology ,Reverse transcriptase ,covid-19 ,Nasal Swab ,Surgery ,business - Abstract
Background This study was performed to investigate the presence of SARS-CoV-2 virus in wounds of COVID-19 positive patients. Methods This is a single-center observational study. COVID-19 patients with wounds (traumatic/infective/surgical) were included in this study. Preoperative, intraoperative, or postoperative specimens were collected and analyzed with real-time reverse transcriptase polymerase chain reaction (rRT-PCR) to know the presence of the virus. Results A total of eight patients were included in this study. Eleven samples were collected (seven wound swabs, two peritoneal fluids, and two tissue specimens) and analyzed. None of the samples from the wound tested positive for the virus while they were tested positive for nasal swab taken simultaneously or within 3 days prior. Conclusion The wounds of COVID-19 patients are considered negative and can be managed with routine wound precautions.
- Published
- 2020
- Full Text
- View/download PDF
32. Natural Inflammatory Molecules in Fruits and Vegetables
- Author
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Pasqualina Laganà, Ramesh Kumar Sharma, and Maria Anna Coniglio
- Subjects
Natural Inflammatory Molecule ,Fruits and vegetables ,Cytotoxicity ,Alkaloid ,Inflammatory molecules ,Bacterial Wilt ,Reactive nitrogen species ,Food science ,Glutathione ,Reactive oxygen species ,Biology ,Natural (archaeology) - Published
- 2021
33. Columellar strut graft in unilateral cleft nasal deformity: Anthropometry and clinical outcomes
- Author
-
Atul Parashar, Kumar Prasad Preetha Rani, and Ramesh Kumar Sharma
- Subjects
Orthodontics ,Nasal deformity ,business.industry ,medicine.medical_treatment ,lcsh:Surgery ,General Medicine ,lcsh:RD1-811 ,Anthropometry ,Nasofacial angle ,Rhinoplasty ,tip projection ,lcsh:RK1-715 ,Nasolabial angle ,medicine.anatomical_structure ,Lateral cartilage ,lcsh:Dentistry ,columellar strut graft ,Medicine ,business ,Strut graft ,Nose ,unilateral cleft nasal deformity - Abstract
Introduction: The cleft nasal deformity is a three-dimensional asymmetry involving all layers of the nose. Columellar strut graft is an important method to provide support to the skeletal framework in an attempt to retain structural support and balance. Aims: The purpose of our study is to describe the surgical outcomes following the use of columellar strut graft when it is used in secondary cleft rhinoplasty. The study was designed to identify the changes in tip projection (Tip Proj), tip rotation (Tip Rot), and other anthropometric measurements postoperatively. Materials and Methods: A prospective study was conducted among patients presenting with secondary cleft nasal deformity and operated utilizing a columellar strut graft. The parameters considered were columellar height (CH), columellar width, Tip Proj, Tip Rot, nasofrontal angle, nasofacial angle, and nasolabial angle. All the measurements were analyzed statistically. Results: During the study, results could be evaluated for 25 patients. The Tip Proj increased in 84% of patients, and the magnitude of difference between pre- and post-operative follow-up at 9 months was found to be statistically significant (P = 0.009). The CH increased in 20 patients (80%). The Tip Rot increased in 20 patients (80%). The postoperative changes were consistently maintained at different follow-up intervals. Conclusions: Columellar strut is necessary in improving the Tip Proj, correcting the tilted tripod and lower lateral cartilage deformities. It also functions as a central scaffold on which the tip structures can be unified.
- Published
- 2019
34. Role of fat graft alone versus enriched fat graft with stromal vascular filtrate in painful amputation stump
- Author
-
Ratti Ram Sharma, Parvesh Malik, Ramesh Kumar Sharma, Sunil Gaba, Niranjan Khandelwal, and Chirag Kamal Ahuja
- Subjects
Adipose-derived stem cells ,medicine.medical_specialty ,medicine.medical_treatment ,Scars ,Prosthesis ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,lcsh:Orthopedic surgery ,law ,amputation stump ,Medicine ,Orthopedics and Sports Medicine ,030222 orthopedics ,Rehabilitation ,medicine.diagnostic_test ,Autologous Fat Graft ,stromal vascular filtrate ,business.industry ,Magnetic resonance imaging ,030229 sport sciences ,Surgery ,lcsh:RD701-811 ,Amputation ,Orthopedic surgery ,Original Article ,medicine.symptom ,business ,fat grafting - Abstract
Background: Traumatic amputations are very prevalent in today's world. Successful rehabilitation of an amputee largely depends on how well he/she adapt to prosthesis. However, because of poor scar characteristics, these patients often complain of pain while using prosthesis. Autologous fat graft is being vastly used all over the world to improve the scar of various etiologies. However, it has been associated with unpredictable resorption rate. Objectives: We report the results of the study which was done to assess the consequences of fat grafting over scars and to see its effects on pain management in amputated stump and compare the autologous fat graft with stromal vascular filtrate (SVF)-enriched fat graft for scar remodeling and pain modulation on amputation stumps. Materials and Methods: A prospective randomized trial was conducted from July 2014 to December 2015. A group of ten patients, who were unable to wear prosthesis due to painful amputation stump, incorporated in the study and randomly distributed in two groups. Group A of five patients (case group) was treated with autologous fat graft enriched with SVF while Group B (control group) of remaining five patients was treated with fat graft alone. The results were assessed at baseline, at 1 month, and at 6 months postoperatively using patient and observer scar assessment scale (POSAS) score. Magnetic resonance imaging (MRI) was done to compare fat content preoperatively and 6 months postoperatively. Results: All ten patients reported improvement in scar characteristics, most notably in pain in both scales of POSAS score. The improvement was comparable in both groups. However, the fat content in case group was significantly more in comparison to control group when assessed 6 months postoperatively using MRI scan. Conclusion: Autologous fat grafting is a viable and minimally invasive solution for painful amputation stump. Enrichment of fat graft with SVF can enhance its viability over long term. This study was done as a pilot project. Hence, further long term studies with large sample size are needed to ascertain the benefits observed in this study.
- Published
- 2019
35. Natural Inflammatory Molecules in Fruits and Vegetables
- Author
-
Ramesh Kumar Sharma, Maria Anna Coniglio, Pasqualina Laganà, Ramesh Kumar Sharma, Maria Anna Coniglio, and Pasqualina Laganà
- Subjects
- Vegetables, Fruit, Anti-inflammatory agents
- Abstract
This book explores the role that some natural molecules found in fruits and vegetables, and their derivatives, play in excessive oxidation reactions that lead to inflammation in the human body. Particular attention is given to oxidation during food processing, especially when it comes to high-energy foods (derived from cereals) with notable amounts of oxidation-sensible lipids and protein chains. This book critically assesses the increased consumption of high-energy foods from a public health perspective. In addition, it provides an overview of the research into the unsaturated fatty acids and polypeptides responsible for nitric oxide production and elucidates the analytical identification of natural inflammatory molecules in fruits and vegetables. The book appeals not only to academic researchers and professors interested in public hygiene and food safety; medicine; food production; HACCP studies, but also to public health practitioners, and regulatory specialists and consultants.
- Published
- 2022
36. Indian Herbal Medicines : Antioxidant and Antimicrobial Properties
- Author
-
Ramesh Kumar Sharma, Maria Micali, Bhupendra Kumar Rana, Alessandra Pellerito, Rajeev K. Singla, Ramesh Kumar Sharma, Maria Micali, Bhupendra Kumar Rana, Alessandra Pellerito, and Rajeev K. Singla
- Subjects
- Herbs--Therapeutic use--India
- Abstract
This book discusses the scope and limitations of the antimicrobial and antioxidant properties of foods as medicines or medicinal coadjuvants in traditional Indian herbal therapies. The first chapter introduces readers to the relevance of the Ayurveda system, its holistic classification approach, applications of selected herbs and the demonstrable efficacy of herbal extracts in terms of antimicrobial susceptibility. In turn, the second chapter discusses the antimicrobial properties and kinetic mechanisms of inhibition ascribed to selected vegetable extracts. The third chapter addresses the antioxidant power of phenolic compounds from vegetable products and herbal extracts. The book closes with a review of natural antioxidant agents'role in the treatment of metabolic disorders. Written from an Indian perspective, this book unravels the chemistry of the traditional Indian diet and its impact on health. Further, it can serve as a reference for other traditional productswith similar health claims.
- Published
- 2021
37. Professor Chakkiri Balakrishnan: The Guru of Gurus
- Author
-
Ramesh Kumar Sharma
- Subjects
business.industry ,MEDLINE ,lcsh:Surgery ,Medicine ,Library science ,Surgery ,lcsh:RD1-811 ,business - Published
- 2018
- Full Text
- View/download PDF
38. High-pressure chemical injection injury to the hand: usually underestimated injury with major consequences
- Author
-
Jerry R. John, Ramesh Kumar Sharma, and Raman Sharma
- Subjects
Adult ,Male ,Injury control ,Poison control ,Wounds, Penetrating ,Ferric Compounds ,03 medical and health sciences ,0302 clinical medicine ,Injury prevention ,Pressure ,Medicine ,Humans ,Therapeutic Irrigation ,Physical Therapy Modalities ,Analgesics ,Hand function ,business.industry ,Wound Closure Techniques ,Surgical debridement ,Hand Injuries ,Normal colour ,General Medicine ,Foreign Bodies ,Hand ,Occupational Injuries ,Reminder of Important Clinical Lesson ,Anti-Bacterial Agents ,Fasciotomy ,Injected material ,Radiography ,Forearm ,Debridement ,Splints ,030220 oncology & carcinogenesis ,Anesthesia ,High pressure ,business ,030217 neurology & neurosurgery - Abstract
The damages caused by high-pressure injuries are often underestimated. Such incidents are characterised by a small punctiform entry wound and the normal colour of skin. The internal damage caused by these injuries can be severely devastating in nature. These injuries required emergent surgical debridement and irrigation. Postoperatively intensive physiotherapy is required for the successful return of hand function. The final functional outcome depends on the initial latency to treatment, nature of injected material, location and volume of injection and postoperative physiotherapy.
- Published
- 2019
39. Toxins and Contaminants in Indian Food Products
- Author
-
Ramesh Kumar Sharma, Salvatore Parisi, Ramesh Kumar Sharma, and Salvatore Parisi
- Subjects
- Food contamination--India, Food--Toxicology--India
- Abstract
This book discusses different aspects of contamination in Indian food products. Particular attention is given to the presence and analytical detection of detrimental substances such as pesticides, mycotoxins and other biologically-produced toxins, food chemicals and additives with natural or industrial origin. Furthermore, the book addresses the production and the commercial exploitation of native botanical ingredients, and the question if such ingredients should be regarded as foods or drugs. It also sheds light on chemical aspects of organic farming practices in India. Readers will also find information on pesticides and other detrimental chemicals detection in Indian farming. The authors present a useful opinion on how and why food contaminants can lead to border rejections during export, in particular to the European Union.
- Published
- 2017
40. Comparison of the nutritional status and outcome in thermal burn patients receiving vegetarian and non-vegetarian diets
- Author
-
Atul Parashar, Ramesh Kumar Sharma, and Samira Sharma
- Subjects
medicine.medical_specialty ,Calorie ,lcsh:Surgery ,Food habits ,wound healing ,030230 surgery ,Vegetarian diets ,03 medical and health sciences ,burns ,0302 clinical medicine ,Graft take ,Internal medicine ,Medicine ,non-vegetarian ,business.industry ,vegetarian ,030208 emergency & critical care medicine ,Nutritional status ,lcsh:RD1-811 ,Thermal burn ,Surgery ,Original Article ,business ,diet ,Hospital stay - Abstract
Background: The importance of adequate nutritional support in burned patients cannot be overemphasised. For adequate long-term compliance by the patients, diet should be formulated in accordance with their pre-burn dietary habits, religious beliefs, and tastes. Patients and Methods: A study was conducted in 42 consecutive patients suffering from 10% to 50% of 2nd and 3rd degree thermal burns with the aim to compare nutritional status, clinical outcome, and cost-effectiveness of vegetarian and non-vegetarian diets. The patients were divided into two groups depending upon their pre-injury food habits. Total calories were calculated by Curreri formula. Both groups were compared by various biochemical parameters, microbiological investigations, weight , status of wound healing, graft take, and hospital stay and they were followed for at least 60 days postburn. Results: The results were comparable in both groups. Vegetarian diet was found to be more palatable and cost-effective. Conclusion: Vegetarian diet is a safe and viable option for the patients suffering from burn injury. The common belief that non-vegetarian diet is superior to vegetarian diet is a myth.
- Published
- 2014
- Full Text
- View/download PDF
41. Chemistry and Food Safety in the EU : The Rapid Alert System for Food and Feed (RASFF)
- Author
-
Salvatore Parisi, Caterina Barone, Ramesh Kumar Sharma, Salvatore Parisi, Caterina Barone, and Ramesh Kumar Sharma
- Subjects
- Food--Composition, Food--Europe--Safety measures, Food--Analysis
- Abstract
This Brief provides a general description of the European Rapid Alert System for Food and Feed (RASFF). It describes the RASFF approach on the legal level and with reference to notification procedures, including also new tools, which were launched in 2014: iRASFF and the RASFF Consumer Portal. In an introduction, the present status of the RASFF, which had originally been introduced in 1979, is briefly reviewed. It is described as the main basis of modern food policy in Europe, enabling member countries to take rapid corrective actions on the one hand, and to perform statistically reliable analyses of food-related hazards on the other hand. One chapter contains a statistical evaluation of RASFF notifications in general, and specifically with regard to chemical contaminants, including also allergens. In another chapter, reasons for rejections of food and feed at the European borders are analyzed in selected case studies. The Brief provides an easy description for the chemical dangersand contaminants it is referring to, outlining the names, properties, uses and importance in the food and feed industry, toxicological effects, and contamination sources. The last chapter offers an outlook on the future of the RASFF and possible expectations.
- Published
- 2016
42. Universal Splint for upper limb support during reconstruction by pedicled abdominal flap
- Author
-
Harbans Singh, Ramesh Kumar Sharma, and Bharat Mishra
- Subjects
Orthodontics ,business.industry ,medicine.medical_treatment ,lcsh:Surgery ,lcsh:RD1-811 ,computer.software_genre ,medicine.anatomical_structure ,medicine ,Upper limb ,Surgery ,Data mining ,business ,Splint (medicine) ,Letters to Editor ,computer - Published
- 2015
- Full Text
- View/download PDF
43. Unfavourable outcomes in maxillofacial injuries: How to avoid and manage
- Author
-
Ramesh Kumar Sharma and Atul Parashar
- Subjects
Post traumatic deformity ,medicine.medical_specialty ,medicine.diagnostic_test ,Craniofacial skeleton ,business.industry ,Adverse outcomes ,lcsh:Surgery ,Physical examination ,Review Article ,lcsh:RD1-811 ,Surgery ,Computed tomographic ,post-traumatic deformity ,Treatment plan ,Form and function ,fracture ,Medicine ,business ,Intensive care medicine ,faciomaxillary injuries - Abstract
Faciomaxillary injuries remain one of the common injuries managed by plastic surgeons. The goal of treatment in these injuries is the three-dimensional restoration of the disturbed anatomy so as to achieve pre-injury form and function. In this article, the authors review the anatomic, diagnostic and management considerations to optimise results and minimise the late post-traumatic deformities. Most of the adverse outcomes are usually a result of poorly addressed underlying structural injury during the primary management. An accurate physical examination combined with detailed computed tomographic scanning of the craniofacial skeleton is required to generate an appropriate treatment plan. This organised approach has proven effective in restoring the injured structures to pre-injury status. Multiple clinical cases are used to illustrate the different fracture patterns along with various surgical techniques to achieve an acceptable outcome. Early diagnosis and timely management of complications in these complex injuries is also discussed.
- Published
- 2013
44. Protocol of an observational study to evaluate diabetic nephropathy through detection of microalbuminuria in Indian patients
- Author
-
Brij Mohan, Sanjay Kalra, Pradeep G Talwalkar, Ramesh Kumar Sharma, Gokulnath, Vijay Vishwanathan, Debasish Maji, Jasmeet Singh Sahni, Ganapathi Bantwal, G Vijay Kumar, Abdul Hamid Zargar, Deodatta Chafekar, Anil Bansali, Subhash Kumar Wangnoo, and Manisha Sahay
- Subjects
medicine.medical_specialty ,microalbuminuria ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,dipstick test ,India ,Diabetic nephropathy ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Endocrinology ,Internal medicine ,medicine ,lcsh:RC799-869 ,Disease burden ,lcsh:RC648-665 ,business.industry ,Type 2 Diabetes Mellitus ,health policy ,Dipstick ,medicine.disease ,Surgery ,Blood pressure ,Microalbuminuria ,lcsh:Diseases of the digestive system. Gastroenterology ,Original Article ,business ,Kidney disease - Abstract
Aim: To assess the prevalence of persistent microalbuminuria (MAU), its clinical correlates by dip stick method, its predictive value for potential kidney disease and the utility of this test as objective cue for health care seeking behavior in adult Indian patients with type 2 diabetes mellitus. Materials and Methods: Approximately 400,000 patients shall be enrolled in this multicentric, cross sectional study. Patients meeting eligibility criteria shall be screened for MAU through urine dipstick test using random daytime single spot urine specimen. Result shall be expressed either positive or negative based on the presence or absence of albumin in the urine and will be correlated with the corresponding random blood glucose. Height, weight, waist circumference and blood pressure shall be assessed. There will be three visits with a minimum interval of 28 days between two visits, to be completed within 180 days, and at least two of three urine tests measured in this period must show elevated albumin levels to diagnose MAU. Conclusion: Detection of MAU through the dipstick method is postulated to be a rapid, reliable test for early detection of diabetic nephropathy, which, in turn will help the physician to plan treatment strategy. Further, it will help to identify the disease burden on the individual and society, and may serve as an objective cue for improved health care seeking behavior, as well as a catalyst for health policy change.
- Published
- 2013
45. Role of insulin as a growth promoter in regulating the response of curcumin in human primary gingival fibroblasts: An in vitro study
- Author
-
Anil K. Balapure, Ramesh Kumar Sharma, Karamjeet, Jaya Dixit, and Umesh Pratap Verma
- Subjects
insulin ,Ethanol ,Serial dilution ,Cell growth ,Insulin ,medicine.medical_treatment ,Apoptosis ,Biology ,Molecular biology ,lcsh:RK1-715 ,chemistry.chemical_compound ,Biochemistry ,chemistry ,lcsh:Dentistry ,Curcumin ,medicine ,gingival fibroblasts ,Periodontics ,cytotoxicity ,Original Article ,curcumin ,Viability assay ,Cytotoxicity - Abstract
Background: The aim of this investigation was to evaluate the biochemical and morphologic changes in human primary gingival fibroblasts (hPGF) treated with curcumin (CUR) and insulin (I) plus curcumin (CUR) in a dose-dependent fashion. Materials and Methods: Human gingival fibroblasts were obtained from gingival biopsies. Curcumin was dissolved in ethanol, diluted with Dulbecco′s modified Eagle′s medium (DMEM) to obtain dilutions and bovine insulin was dissolved in 0.01 N HCl and diluted with DMEM. Cells were exposed to different concentrations of CUR and insulin (1 µg/ml) plus CUR for next 48 hours at 37°C and cellular growth profile was assessed using sulforhodamine-B (SRB), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and fluorescence-activated cell sorter (FACS). Results: The cell viability in both the treatments at lower concentrations of SRB (1 and 10 µM) and MTT (1 µM) were found to be significantly higher than that observed at higher concentrations, while apoptosis in both the treatments at lower concentrations was observed to be significantly lower than at higher concentrations. Also, the cell viability of I + CUR at lower concentrations of SRB (1, 10 and 25 µM) and MTT (1 µM) were found to be significantly higher than the respective CUR, while apoptosis at higher concentrations (50, 75 and 100 µM), especially at 75 µM was significantly low. The IC 50 of I + CUR of SRB, MTT and FACS were 1.1, 1.0 and 1.4 times higher than respective concentrations of CUR. Conclusions: Insulin (1 µg/ml) exerted cytoproliferative and curcumin exerted cytocidal effects (in a dose-dependent manner) on hPGF. Insulin (1 µg/ml) and curcumin at different concentrations when added together decreased the cytocidal effect of curcumin.
- Published
- 2009
46. Submental tracheal intubation in oromaxillofacial surgery
- Author
-
Surinder Makkar, Chacko Cyriac, Ramesh Kumar Sharma, Puneet Tuli, and Atul Parashar
- Subjects
Hemostat ,medicine.medical_specialty ,Dental occlusion ,business.industry ,medicine.medical_treatment ,Tracheal intubation ,Forceps ,lcsh:Surgery ,lcsh:RD1-811 ,Nasal bone ,oromaxillofacial surgery ,intubation ,Surgery ,Ceiling balloon ,Blunt ,Avoiding tracheostomy ,medicine ,Intubation ,Original Article ,business - Abstract
Background: oromaxillofacial surgical procedures present a unique set of problems both for the surgeon and for the anesthesist. achieving dental occlusion is one of the fundamental aims of most oromaxillofacial procedures. oral intubation precludes this surgical prerequisite of checking dental occlusion. having the tube in the field of surgery is often disturbing for the surgeon too, especially in the patient for whom skull base surgery is planned. nasotracheal intubation is usually contraindicated in the presence of nasal bone fractures seen either in isolation or as a component of le fort fractures. we utilized submental endotracheal intubation in such situations and the experience has been very satisfying.materials and methods: the technique has been used in 20 patients with maxillofacial injuries and those requiring le fort i approach with or without maxillary swing for skull base tumors. initial oral intubation is done with a flexo-metallic tube. a small 1.5 cm incision is given in the submental region and a blunt tunnel is created in the floor of the mouth staying close to the lingual surface of mandible and a small opening is made in the mucosa. the tracheal end of tube is stabilized with magil′s forceps, and the proximal end is brought out through submental incision by using a blunt hemostat taking care not to injure the pilot balloon. at the end of procedure extubation is done through submental location only.results: the technique of submental intubation was used in a series of twenty patients from january 2005 to date. there were fifteen male patients and five female patients with a mean age of twenty seven years (range 10 to 52). seven patients had le fort i osteotomy as part of the approach for skull base surgery. twelve patients had midfacial fractures at the le fort ii level, of which 8 patients in addition had naso-ethomoidal fractures and 10 patients an associated fracture mandible. twelve patients were extubated in the theatre. eight patients had delayed extubation in the post-operative ward between 1 and 3 days postoperatively.conclusion: in conclusion, the submental intubation technique has proved to be a simple solution for many a difficult problem one would encounter during oromaxillofacial surgical procedures. it provides a safe and reliable route for the endotracheal tube during intubation while staying clear of the surgical field and permitting the checking of the dental occlusion, all without causing any significant morbidity for the patient. its usefulness both in the emergency setting and for elective procedures has been proved. the simplicity of the technique with no specialized equipment or technical expertise required makes it especially advantageous. this technique therefore, when used in appropriate cases, allows both the surgeon and the anesthetist deliver a better quality of patient care.
- Published
- 2008
47. De-epithelialised fasciocutaneous turnover flap: An alternative for defects in lower thigh and knee joint
- Author
-
Vipul Nanda, Ramesh Kumar Sharma, Surinder Makkar, and Atul Parasher
- Subjects
musculoskeletal diseases ,turnover flap ,medicine.medical_specialty ,de-epithelialised ,business.industry ,lcsh:Surgery ,Anatomy ,lcsh:RD1-811 ,Knee Joint ,Thigh ,lower thigh ,eye diseases ,Surgery ,knee joint ,Fasciocutaneous flap ,Plastic surgery ,medicine.anatomical_structure ,Medicine ,business - Abstract
We describe the use of proximally based de-epithelialised fasciocutaneous flap for coverage of defects in the lower thigh and knee joint. These flaps are based on a number of perforators around the knee joint and can be based either posteriorly, posteromedially or posterolaterally depending upon the location of the defect. The whole of the flap including the bridge segment is de-epithelialised and turned over by 180 degrees and a split thickness graft is placed over the flap and the donor site. The flaps can be raised quickly, have minimum morbidity and are reliable even in the presence of extensive injuries. These flaps have remained stable and trouble free during a follow up period of 2-4 years.
- Published
- 2004
- Full Text
- View/download PDF
48. Abstract: Liposomal Based Delivery System for Intralesional Bleomycin in the Treatment of Keloids and Hypertrophic Scars
- Author
-
Atul Parashar, Ramesh Kumar Sharma, Deepak Kaul, and Bharat Mishra
- Subjects
medicine.medical_specialty ,business.industry ,PSTM 2017 Abstract Supplement ,lcsh:Surgery ,lcsh:RD1-811 ,Bleomycin ,Dermatology ,Reconstructive Session 2 ,Sunday, October 8, 2017 ,chemistry.chemical_compound ,chemistry ,Medicine ,Surgery ,Delivery system ,Hypertrophic scars ,skin and connective tissue diseases ,business - Published
- 2017
- Full Text
- View/download PDF
49. Splinting the penis for split skin grafting: Use of longitudinally split plastic syringe
- Author
-
Chacko Cyriac and Ramesh Kumar Sharma
- Subjects
Penile Shaft ,medicine.medical_specialty ,integumentary system ,business.industry ,medicine.medical_treatment ,skin grafting ,lcsh:Surgery ,Penile shaft ,lcsh:RD1-811 ,Surgery ,Avulsion ,medicine.anatomical_structure ,immobilization ,medicine ,Skin grafting ,Plastic Syringe ,business ,Bandage ,Syringe ,Penis - Abstract
We describe a new method of splinting the penile shaft following split skin grafting for avulsion injuries of the penis. A 10 ml syringe is split longitudinally and one half is applied either dorsally or ventrally after placing absorbent dressing on the grafted area. This is then held in place with either tape or bandage.
- Published
- 2006
50. Local perforator island flaps in post-traumatic reconstruction of middle third of the leg
- Author
-
Jerry R. John and Ramesh Kumar Sharma
- Subjects
Lower extremity ,Open fracture ,medicine.medical_specialty ,Tibia ,business.industry ,Short Communication ,Island Flaps ,Trauma ,Lower limb ,Surgery ,Tissue defect ,Perforator island flap ,Orthopedic surgery ,medicine ,Orthopedics and Sports Medicine ,business ,Perforator flaps - Abstract
Perforator flaps have been introduced for coverage of local and distant defects. Various designs of this flap are possible, but their role in the setting of trauma is debated. We report that it is possible to raise these flaps in cases of post-traumatic lower limb reconstruction with good results. Consideration must be given to the type of movement that is planned vis-a-vis the number of perforators identified.
- Full Text
- View/download PDF
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