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3 results on '"Rajendra Narayan Dash"'

1. An integrated Taguchi and response surface methodological approach for the optimization of an HPLC method to determine glimepiride in a supersaturatable self-nanoemulsifying formulation

Author

Rajendra Narayan Dash, Habibuddin Mohammed, and Touseef Humaira

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

We studied the application of Taguchi orthogonal array (TOA) design during the development of an isocratic stability indicating HPLC method for glimepiride as per TOA design; twenty-seven experiments were conducted by varying six chromatographic factors. Percentage of organic phase was the most significant (p

Published
2016
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2. An integrated Taguchi and response surface methodological approach for the optimization of an HPLC method to determine glimepiride in a supersaturatable self-nanoemulsifying formulation

Author

Touseef Humaira, Habibuddin Mohammed, and Rajendra Narayan Dash

Subjects
Optimization, Correlation coefficient, Taguchi orthogonal array, Pharmaceutical Science, Interaction, computer.software_genre, 01 natural sciences, Taguchi methods, Response surface methodology, medicine, Mathematics, Pharmacology, Chromatography, 010405 organic chemistry, 010401 analytical chemistry, lcsh:RM1-950, 0104 chemical sciences, Volumetric flow rate, Glimepiride, HPLC method, lcsh:Therapeutics. Pharmacology, Signal-to-noise ratio (imaging), S-SNEDDS, Signal-to-noise ratio, Original Article, Theoretical plate, Data mining, computer, medicine.drug
Abstract

We studied the application of Taguchi orthogonal array (TOA) design during the development of an isocratic stability indicating HPLC method for glimepiride as per TOA design; twenty-seven experiments were conducted by varying six chromatographic factors. Percentage of organic phase was the most significant (p

Published
2016

3. Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution

Author

Habibuddin Mohammed, Rajendra Narayan Dash, Devi Ramesh, and Touseef Humaira

Subjects
Pharmacology, Materials science, Chromatography, Central composite design, Dissolution enhancement, Pharmaceutical Science, Amorphous solid, Adsorption, Pulmonary surfactant, Nanoemulsion, Drug delivery, medicine, SNEDDS, Original Article, Solubility, Solubility enhancement, Dissolution, Glipizide, medicine.drug
Abstract

A solid self-nanoemulsifying drug-delivery system (solid SNEDDS) has been explored to improve the solubility and dissolution profile of glipizide. SNEDDS preconcentrate was systematically optimized using a circumscribed central composite design by varying Captex 355 (Oil), Solutol HS15 (Surfactant) and Imwitor 988 (Co-surfactant). The optimized SNEDDS preconcentrate consisted of Captex 355 (30% w/w), Solutol HS15 (45% w/w) and Imwitor 988 (25% w/w). The saturation solubility (SS) of glipizide in optimized SNEDDS preconcentrate was found to be 45.12 ± 1.36 mg/ml, indicating an improvement (1367 times) of glipizide solubility as compared to its aqueous solubility (0.033 ± 0.0021 mg/ml). At 90% SS, glipizide was loaded to the optimized SNEDDS. In-vitro dilution of liquid SNEDDS resulted in a nanoemulsion with a mean droplet size of 29.4 nm. TEM studies of diluted liquid SNEDDS confirmed the uniform shape and size of the globules. The liquid SNEDDS was adsorbed onto calcium carbonate and talc to form solid SNEDDS. PXRD, DSC, and SEM results indicated that, the presence of glipizide as an amorphous and as a molecular dispersion state within solid SNEDDS. Glipizide dissolution improved significantly (p

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