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1. The association between dietary fiber intake and gastric cancer: a pooled analysis of 11 case–control studies

Author

Collatuzzo, Giulia, Cortez Lainez, Jacqueline, Pelucchi, Claudio, Negri, Eva, Bonzi, Rossella, Palli, Domenico, Ferraroni, Monica, Zhang, Zuo-Feng, Yu, Guo-Pei, Lunet, Nuno, Morais, Samantha, López-Carrillo, Lizbeth, Zaridze, David, Maximovitch, Dmitry, Guevara, Marcela, Santos-Sanchez, Vanessa, Vioque, Jesus, Garcia de la Hera, Manoli, Ward, Mary H., Malekzadeh, Reza, Pakseresht, Mohammadreza, Hernández-Ramírez, Raúl Ulises, Turati, Federica, Rabkin, Charles S., Liao, Linda M., Sinha, Rashmi, López-Cervantes, Malaquias, Tsugane, Shoichiro, Hidaka, Akihisa, Camargo, M. Constanza, Curado, Maria Paula, Zubair, Nadia, Kristjansson, Dana, Shah, Shailja, La Vecchia, Carlo, and Boffetta, Paolo

Published
2024
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3. Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project

Author

Sassano, Michele, Seyyedsalehi, Monireh Sadat, Collatuzzo, Giulia, Pelucchi, Claudio, Bonzi, Rossella, Ferraroni, Monica, Palli, Domenico, Yu, Guo-Pei, Zhang, Zuo-Feng, López-Carrillo, Lizbeth, Lunet, Nuno, Morais, Samantha, Zaridze, David, Maximovich, Dmitry, Martín, Vicente, Castano-Vinyals, Gemma, Vioque, Jesús, González-Palacios, Sandra, Ward, Mary H., Malekzadeh, Reza, Pakseresht, Mohammadreza, Hernández-Ramirez, Raul Ulises, López-Cervantes, Malaquias, Negri, Eva, Turati, Federica, Rabkin, Charles S., Tsugane, Shoichiro, Hidaka, Akihisa, Lagiou, Areti, Lagiou, Pagona, Camargo, M. Constanza, Curado, Maria Paula, Boccia, Stefania, La Vecchia, Carlo, and Boffetta, Paolo

Published
2024
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4. Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project

Author

Song, Minkyo, Jayasekara, Harindra, Pelucchi, Claudio, Rabkin, Charles S., Johnson, Kenneth C., Hu, Jinfu, Palli, Domenico, Ferraroni, Monica, Liao, Linda M., Bonzi, Rossella, Zaridze, David, Maximovitch, Dmitry, Aragonés, Nuria, Martin, Vicente, Castaño-Vinyals, Gemma, Guevara, Marcela, Tsugane, Shoichiro, Hamada, Gerson Shigueaki, Hidaka, Akihisa, Negri, Eva, Ward, Mary H., Sinha, Rashmi, Lagiou, Areti, Lagiou, Pagona, Boffetta, Paolo, Curado, Maria Paula, Lunet, Nuno, Vioque, Jesus, Zhang, Zuo-Feng, La Vecchia, Carlo, and Camargo, M. Constanza

Published
2024
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5. Implementation of the updated Sydney system biopsy protocol improves the diagnostic yield of gastric preneoplastic conditions: Results from a real-world study

Author

Latorre, Gonzalo, Vargas, José Ignacio, Shah, Shailja C., Ivanovic-Zuvic, Danisa, Achurra, Pablo, Fritzsche, Martín, Leung, Jai-Sen, Ramos, Bernardita, Jensen, Elisa, Uribe, Javier, Montero, Isabella, Gandara, Vicente, Robles, Camila, Bustamante, Miguel, Silva, Felipe, Dukes, Eitan, Corsi, Oscar, Martínez, Francisca, Binder, Victoria, Candia, Roberto, González, Robinson, Espino, Alberto, Agüero, Carlos, Sharp, Allan, Torres, Javiera, Roa, Juan Carlos, Pizarro, Margarita, Corvalan, Alejandro H., Rabkin, Charles S., Camargo, M. Constanza, and Riquelme, Arnoldo

Published
2024
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8. The mediating role of combined lifestyle factors on the relationship between education and gastric cancer in the Stomach cancer Pooling (StoP) Project

Author

Alicandro, Gianfranco, Bertuccio, Paola, Collatuzzo, Giulia, Pelucchi, Claudio, Bonzi, Rossella, Liao, Linda M., Rabkin, Charles S., Sinha, Rashmi, Negri, Eva, Dalmartello, Michela, Zaridze, David, Maximovich, Dmitry, Vioque, Jesus, Garcia de la Hera, Manoli, Tsugane, Shoichiro, Hidaka, Akihisa, Hamada, Gerson Shigueaki, López-Carrillo, Lizbeth, Hernández-Ramírez, Raúl Ulises, Malekzadeh, Reza, Pourfarzi, Farhad, Zhang, Zuo-Feng, Kurtz, Robert C., Camargo, M. Constanza, Curado, Maria Paula, Lunet, Nuno, Boffetta, Paolo, and La Vecchia, Carlo

Published
2022
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9. Tea consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium

Author

Martimianaki, Georgia, Alicandro, Gianfranco, Pelucchi, Claudio, Bonzi, Rossella, Rota, Matteo, Hu, Jinfu, Johnson, Kenneth C., Rabkin, Charles S., Liao, Linda M., Sinha, Rashmi, Zhang, Zuo-Feng, Dalmartello, Michela, Lunet, Nuno, Morais, Samantha, Palli, Domenico, Ferraroni, Monica, Yu, Guo-Pei, Tsugane, Shoichiro, Hidaka, Akihisa, Curado, Maria Paula, Dias-Neto, Emmanuel, Zaridze, David, Maximovitch, Dmitry, Vioque, Jesus, Garcia de la Hera, Manoli, López-Carrillo, Lizbeth, Hernández-Ramírez, Raúl Ulises, Hamada, Gerson Shigueaki, Ward, Mary H., Mu, Lina, Malekzadeh, Reza, Pourfarzi, Farhad, Trichopoulou, Antonia, Karakatsani, Anna, Kurtz, Robert C., Lagiou, Areti, Lagiou, Pagona, Boccia, Stefania, Boffetta, Paolo, Camargo, M. Constanza, Negri, Eva, and La Vecchia, Carlo

Published
2022
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10. Salt intake and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project

Author

Morais, Samantha, Costa, Adriana, Albuquerque, Gabriela, Araújo, Natália, Pelucchi, Claudio, Rabkin, Charles S., Liao, Linda M., Sinha, Rashmi, Zhang, Zuo-Feng, Hu, Jinfu, Johnson, Kenneth C., Palli, Domenico, Ferraroni, Monica, Bonzi, Rossella, Yu, Guo-Pei, López-Carrillo, Lizbeth, Malekzadeh, Reza, Tsugane, Shoichiro, Hidaka, Akihisa, Hamada, Gerson Shigueaki, Zaridze, David, Maximovitch, Dmitry, Vioque, Jesus, de la Hera, Manoli García, Moreno, Victor, Vanaclocha-Espi, Mercedes, Ward, Mary H., Pakseresht, Mohammadreza, Hernández-Ramirez, Raúl Ulises, López-Cervantes, Malaquias, Pourfarzi, Farhad, Mu, Lina, Kurtz, Robert C., Boccia, Stefania, Pastorino, Roberta, Lagiou, Areti, Lagiou, Pagona, Boffetta, Paolo, Camargo, M. Constanza, Curado, Maria Paula, Negri, Eva, La Vecchia, Carlo, and Lunet, Nuno

Published
2022
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11. Comparative outcomes for mature T-cell and NK/T-cell lymphomas in people with and without HIV and to AIDS-defining lymphomas

Author

Koh, Min Jung, Merrill, Mwanasha H., Koh, Min Ji, Stuver, Robert, Alonso, Carolyn D., Foss, Francine M., Mayor, Angel M., Gill, John, Epeldegui, Marta, Cachay, Edward, Thorne, Jennifer E., Silverberg, Michael J., Horberg, Michael A., Althoff, Keri N., Nijhawan, Ank E., McGinnis, Kathleen A., Lee, Jennifer S., Rabkin, Charles S., Napravnik, Sonia, Li, Jun, Castilho, Jessica L., Shen, Changyu, and Jain, Salvia

Published
2022
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17. Associations between eosinophils and cancer risk in the UK Biobank.

Author

Wang, Jeanny H., Rabkin, Charles S., Engels, Eric A., and Song, Minkyo

Subjects
DISEASE risk factors, EOSINOPHILS, CHRONIC leukemia, DIFFUSE large B-cell lymphomas, LEUKOCYTE count, INTRAHEPATIC bile ducts, CHOLANGIOCARCINOMA
Abstract

Eosinophils exhibit anti‐tumor cytotoxic responses in the tumor microenvironment and may contribute to tumor immunosurveillance. To assess the relationship between circulating eosinophils and cancer risk, we analyzed data from 443,542 adults aged 38–73 in the UK Biobank, who were initially cancer‐free, had over a year of follow‐up, and baseline white blood cell count measurements. Using multivariable Cox regression, we estimated hazard ratios (aHR) and 95% confidence intervals (95%CI) for each quartile increase in absolute eosinophil count (AEC) across 58 cancer types, adjusting for relevant confounders. During a median follow‐up of 5.8 years, 22,747 incident cancer cases were diagnosed. We observed an inverse association, which met Bonferroni significance, between AEC and overall cancer risk (aHR, 95%CI 0.97, 0.95–0.98). Notably, 16 cancer types showed borderline associations (p <.05) with AEC, with 12 types displaying an inverse relationship. These included four hematologic cancers (acute and other myeloid leukemia, other lymphocytic leukemia, and chronic lymphocytic leukemia/small lymphocytic lymphoma; aHR range; 0.58–0.87) and eight nonhematologic cancers (melanoma and nose/middle ear, soft tissue/heart, gum/other mouth, tongue, lung, colon, and breast cancers; aHR range: 0.65–0.95). Higher AEC showed a borderline significant association with increased risk for intrahepatic bile duct cancer, Hodgkin lymphoma, diffuse large B‐cell lymphoma, and chronic myeloid leukemia (aHR range: 1.13–1.42). Our study, the largest to date, provides insights into the relationship between blood eosinophils and a comprehensive list of incident cancers. The inverse association between AEC and overall cancer risk suggests a protective role for eosinophils in tumor surveillance. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Brief Report: Protease Inhibitors Versus Nonnucleoside Reverse Transcriptase Inhibitors and the Risk of Cancer Among People With HIV.

Author

Coburn, Sally B., Pimentel, Noel, Leyden, Wendy, Kitahata, Mari M., Moore, Richard D., Althoff, Keri N., Gill, M. John, Lang, Raynell, Horberg, Michael A., D'Souza, GypsyAmber, Hussain, Shehnaz K., Dubrow, Robert, Novak, Richard M., Rabkin, Charles S., Park, Lesley S., Sterling, Timothy R., Neugebauer, Romain S., Silverberg, Michael J., Benson, Constance A., and Bosch, Ronald J.

Published
2024
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19. White Blood Cell Count, Neutrophil-to-Lymphocyte Ratio, and Incident Cancer in the UK Biobank.

Author

Minkyo Song, Graubard, Barry I., Loftfield, Erikka, Rabkin, Charles S., and Engels, Eric A.

Abstract

Background: The peripheral white blood cell (WBC) and neutrophil-to-lymphocyte ratio (NLR) reflect levels of inflammation and adaptive immunity. They are associated with cancer prognosis, but their associations with cancer incidence are not established. Methods: We evaluated 443,540 cancer-free adults in the UK Biobank with data on total WBC and its subsets, follow-up starting one year after baseline. Cox regression was used to estimate hazard ratios (HR) per quartile of WBC or NLR for incidence of 73 cancer types. Results: 22,747 incident cancers were diagnosed during a median of 6.9 years of follow-up. WBC was associated with risk of cancer overall [HR, 1.05; 95% confidence interval (CI), 1.03-1.06], chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL, 2.79; 95% CI, 2.45-3.18), lung cancer (1.14, 95% CI, 1.08-1.20), and breast cancer (95% CI, 1.05-1.02-1.08). NLR was positively associated with cancer overall (HR, 1.03; 95% CI, 1.02-1.04, per quartile) and kidney cancer (1.16; 95% CI, 1.07-1.25), and inversely with CLL/SLL (0.38; 95% CI, 0.33-0.42). Conclusions: High WBC or NLR may reflect excessive inflammatory status, promoting development of some cancers. Conversely, low NLR indicates a relative rise in lymphocytes, which could reflect an increase in circulating premalignant cells before CLL/SLL diagnosis. Peripheral WBC and NLR, in combination with other clinical information or biomarkers, may be useful tools for cancer risk stratification. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations

Author

Au, Wing-Yan, Chiu, Brian, Fan, Lei, Li, Zheng, LAM, Tai Hing, Liang, Raymond, Yeh, Su-Peng, Xu, Jun, Ip, Dennis Kai Ming, Li, Gandi, Xu, Gang, Wang, Xiaodong, Bai, Ou, Cai, Qing-Qing, Xia, Yi, Chen, Jie-Rong, Luo, Chun-Ling, Xiong, Xiang-Yu, Zeng, Yanni, Wei, Pan-Pan, Liu, Chu-Jun, Liu, Yu-Xiang, Cao, Yu-Lu, He, Shuai, Liu, Yang, Ha, Jeslin Chian Hung, Khoo, Lay Poh, Kee, Rebecca Xiangpin, Tan, Jing, Liu, Yanhui, Zhang, Fen, Feng, Yanfen, Rao, Huilan, Chng, Wee Joo, Chan, Jason Yong Sheng, Somasundaram, Nagavalli D/O, Tao, Miriam, Ras, Mohamad Farid Bin Harunal, Yeoh, Kheng-Wei, Goh, Yeow Tee, Ong, Shin Yeu, Grigoropoulos, Nicholas Francis, Wong, Esther Kam Yin, Pang, Jane Wan Lu, Lim, Jing Quan, Chia, Burton Kuan Hui, Kim, Seok Jin, Yoon, Sang Eun, Choi, Seungkyu, Kuo, Ching-Yuan, Chen, Tsai-Yun, Su, Yu-Chieh, Huang, Wen-Tsung, Lee, Ming-Yang, Yao, Wenxiu, Ngan, Kai-Cheong, Liu, Herman, Lee, Harold, Yip, Sze-Fai, Liu, Jie, Li, Jianyong, Rabkin, Charles S., Berndt, Sonja, Bassig, Bryan, Hu, Wei, Zhao, Mingfeng, Li, Yuming, Zhai, Qiongli, Shao, Zonghong, Qiu, Lugui, Wang, Jianxiang, Xu, Fu-Ping, Chen, Ling, Hou, Yu, Xu, Shuangnian, Huang, Zhen, Xie, Mingling, Li, Ming, Zhong, Shilong, Zhang, Yan, Gu, Dongqing, Wang, Xin, Foo, Jia Nee, Li, Zhiqiang, Dai, Juncheng, Sun, Liangdan, Wang, Zhenzhen, Liu, Hong, Zhou, Hui, Sun, Yonghu, Koh, Woon-Puay, Heng, Chew-Kiat, Hong, Chew Soo, Ahn, Jeeyun, Park, Kyu Hyung, Tin, Aung, Gu, Jieruo, Xia, Xiaojun, Li, Bo, Yu, Xueqing, Lin, Guo-Wang, Xu, Caigang, Chen, Kexin, Huang, Hui-Qiang, Chen, Jieping, Song, Bao, Chan, John K C, Li, Wenyu, Liu, Weiping, Shih, Lee-Yung, Chuang, Wen-Yu, Kim, Won Seog, Tan, Wen, Peng, Rou-Jun, Laurensia, Yurike, Cheah, Daryl Ming Zhe, Huang, DaChuan, Cheng, Chee Leong, Su, Yi-Jiun, Tan, Soo-Yong, Ng, Siok-Bian, Tang, Tiffany Pooi Ling, Han, Kyudong, Wang, Vivien Ya-Fan, Jia, Wei-Hua, Pei, Zhong, Li, Ya-Jun, Gao, Song, Shi, Yongyong, Hu, Zhibin, Zhang, Furen, Zhang, Ben, Zeng, Yi-Xin, Shen, Hongbing, He, Lin, Ong, Choon Kiat, Lim, Soon Thye, Chanock, Stephen, Kwong, Yok-Lam, Lin, Dongxin, Rothman, Nathaniel, Khor, Chiea Chuen, Lan, Qing, and Bei, Jin-Xin

Published
2020
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22. Weight gain among treatment-na[euro]ive persons with HIV starting integrase inhibitors compared to non-nucleoside reverse transcriptase inhibitors or protease inhibitors in a large observational cohort in the United States and Canada

Author

Bourgi, Kassem, Jenkins, Cathy A., Rebeiro, Peter F., Palella, Frank, Moore, Richard D., Altoff, Keri N., Gill, John, Rabkin, Charles S., Gange, Stephen J., Horberg, Michael A., Margolick, Joseph, Li, Jun, Wong, Cherise, Willig, Amanda, Lima, Viviane D., Crane, Heidi, Thorne, Jennifer, Silverberg, Michael, Kirk, Gregory, Mathews, William C., Sterling, Timothy R., Lake, Jordan, and Koethe, John R.

Subjects
Gilead Sciences Inc., HIV patients -- Comparative analysis -- Research, Anti-HIV agents -- Research, Nucleosides -- Research -- Comparative analysis, Obesity -- Research, Highly active antiretroviral therapy -- Research -- Comparative analysis, Bictegravir -- Research, DNA polymerases -- Comparative analysis -- Research, Dolutegravir -- Research, Proteases -- Comparative analysis -- Research, Medical research -- Comparative analysis, Biological products industry -- Research -- Comparative analysis, RNA -- Research -- Comparative analysis, Atazanavir -- Research, Darunavir -- Research, HIV -- Research, Body weight -- Research -- Comparative analysis, Health
Abstract

Introduction: Weight gain following antiretroviral therapy (ART) initiation is common, potentially predisposing some persons with HIV (PWH) to cardio-metabolic disease. We assessed relationships between ART drug class and weight change among treatment-na[euro]ive PWH initiating ART in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). Methods: Adult, treatment-na[euro]ive PWH in NA-ACCORD initiating integrase strand transfer inhibitor (INSTI), protease inhibitor (PI) or non-nucleoside reverse-transcriptase inhibitor (NNRTI)-based ART on/after 1 January 2007 were followed through 31 December 2016. Multivariate linear mixed effects models estimated weight up to five years after ART initiation, adjusting for age, sex, race, cohort site, HIV acquisition mode, treatment year, and baseline weight, plasma HIV-1 RNA level and [CD4.sup.+] cell count. Due to shorter follow-up for PWH receiving newer INSTI drugs, weights for specific INSTIs were estimated at two years. Secondary analyses using logistic regression and all covariates from primary analyses assessed factors associated with >10% weight gain at two and five years. Results: Among 22,972 participants, 87% were male, and 41% were white. 49% started NNRTI-, 31% started PI- and 20% started INSTI-based regimens (1624 raltegravir (RAL), 2085 elvitegravir (EVG) and 929 dolutegravir (DTG)). PWH starting INSTI-based regimens had mean estimated five-year weight change of +5.9kg, compared to +3.7kg for NNRTI and +5.5kg for PI. Among PWH starting INSTI drugs, mean estimated two-year weight change was +7.2kg for DTG, +5.8kg for RAL and +4.1kg for EVG. Women, persons with lower baseline [CD4.sup.+] cell counts, and those initiating INSTI-based regimens had higher odds of >10% body weight increase at two years (adjusted odds ratio = 1.37, 95% confidence interval: 1.20 to 1.56 vs. NNRTI). Conclusions: PWH initiating INSTI-based regimens gained, on average, more weight compared to NNRTI-based regimens. This phenomenon may reflect heterogeneous effects of ART agents on body weight regulation that require further exploration. Keywords: integrase inhibitors; weight gain; obesity; metabolic; HIV; North America, 1 | INTRODUCTION Weight gain following antiretroviral therapy (ART) initiation is common among persons with HIV (PWH), particularly those with more pronounced [CD4.sup.+] cell count (CD4) depletion or lower pre-ART [...]

Published
2020
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23. Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium

Author

Martimianaki, Georgia, Bertuccio, Paola, Alicandro, Gianfranco, Pelucchi, Claudio, Bravi, Francesca, Carioli, Greta, Bonzi, Rossella, Rabkin, Charles S., Liao, Linda M., Sinha, Rashmi, Johnson, Ken, Hu, Jinfu, Palli, Domenico, Ferraroni, Monica, Lunet, Nuno, Morais, Samantha, Tsugane, Shoichiro, Hidaka, Akihisa, Hamada, Gerson Shigueaki, López-Carrillo, Lizbeth, Hernández-Ramírez, Raúl Ulises, Zaridze, David, Maximovitch, Dmitry, Aragonés, Nuria, Martin, Vicente, Ward, Mary H., Vioque, Jesus, Garcia de la Hera, Manoli, Zhang, Zuo-Feng, Kurtz, Robert C., Lagiou, Pagona, Lagiou, Areti, Trichopoulou, Antonia, Karakatsani, Anna, Malekzadeh, Reza, Camargo, M. Constanza, Curado, Maria Paula, Boccia, Stefania, Boffetta, Paolo, Negri, Eva, and La Vecchia, Carlo

Published
2022
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25. Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study

Author

Betts, Adrian, Brooks, John T., Freeman, Aimee M., Van Rompaey, Stephen E., Burchell, Ann, Yip, Benita, You, Bin, Hogan, Brenna, Grasso, Chris, Hogg, Robert S., Benson, Constance A., Drozd, Daniel R., Sterling, Timothy R., Haas, David, Humes, Elizabeth, Crane, Heidi M., Willig, James, Eron, Joseph J., Martin, Jeffrey N., Saag, Michael S., Jing, Jerry, Zhang, Jinbing, Lindsay, Joanne, Hunter-Mellado, Robert F., Deeks, Steven G., Zhu, Julia, Montaner, Julio S.G., McReynolds, Justin, Gabler, Karyn, Buchacz, Kate, Rodriguez, Benigno, Thorne, Jennifer E., Margolick, Joseph B., Anastos, Kathryn, Jacobson, Lisa P., Klein, Marina B., Kroch, Abigail, Morton, Liz, Turner, Megan, Fiellin, David, Gange, Stephen J., Mugavero, Michael J., Harrigan, P. Richard, Rebeiro, Peter, Bosch, Ronald J., Kirk, Gregory D., Mayer, Kenneth H., McKaig, Rosemary G., Coburn, Sally, Napravnik, Sonia, Kitahata, Mari M., Lober, William B., Lee, Jennifer S., Hernández-Ramírez, Raúl U, Qin, Li, Lin, Haiqun, Leyden, Wendy, Neugebauer, Romain S, Althoff, Keri N, Achenbach, Chad J, Hessol, Nancy A, D'Souza, Gypsyamber, Gebo, Kelly A, Gill, M John, Grover, Surbhi, Horberg, Michael A, Li, Jun, Mathews, W Christopher, Mayor, Angel M, Park, Lesley S, Rabkin, Charles S, Salters, Kate, Justice, Amy C, Moore, Richard D, Engels, Eric A, Silverberg, Michael J, and Dubrow, Robert

Published
2019
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26. Contributions of traditional and HIV-related risk factors on non-AIDS-defining cancer, myocardial infarction, and end-stage liver and renal diseases in adults with HIV in the USA and Canada: a collaboration of cohort studies

Author

Althoff, Keri N, Gebo, Kelly A, Moore, Richard D, Boyd, Cynthia M, Justice, Amy C, Wong, Cherise, Lucas, Gregory M, Klein, Marina B, Kitahata, Mari M, Crane, Heidi, Silverberg, Michael J, Gill, M John, Mathews, William Christopher, Dubrow, Robert, Horberg, Michael A, Rabkin, Charles S, Klein, Daniel B, Lo Re, Vincent, Sterling, Timothy R, Desir, Fidel A, Lichtenstein, Kenneth, Willig, James, Rachlis, Anita R, Kirk, Gregory D, Anastos, Kathryn, Palella, Frank J, Jr, Thorne, Jennifer E, Eron, Joseph, Jacobson, Lisa P, Napravnik, Sonia, Achenbach, Chad, Mayor, Angel M, Patel, Pragna, Buchacz, Kate, Jing, Yuezhou, and Gange, Stephen J

Published
2019
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27. Multimorbidity Among Persons Living with Human Immunodeficiency Virus in the United States

Author

North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), Wong, Cherise, Gange, Stephen J., Moore, Richard D., Justice, Amy C., Buchacz, Kate, Abraham, Alison G., Rebeiro, Peter F., Koethe, John R., Martin, Jeffrey N., Horberg, Michael A., Boyd, Cynthia M., Kitahata, Mari M., Crane, Heidi M., Gebo, Kelly A., Gill, M. John, Silverberg, Michael J., Palella, Frank J., Patel, Pragna, Samji, Hasina, Thorne, Jennifer, Rabkin, Charles S., Mayor, Angel, and Althoff, Keri N.

Published
2018

38. Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis

Author

Grover, Surbhi, Desir, Fidel, Jing, Yuezhou, Bhatia, Rohini K., Trifiletti, Daniel M., Swisher-McClure, Samuel, Kobie, Julie, Moore, Richard D., Rabkin, Charles S., Silverberg, Michael J., Salters, Kate, Mathews, William Christopher, Gill, Michael John, Thorne, Jennifer E., Castilho, Jessica, Kitahata, Mari M., Justice, Amy, Horberg, Michael A., Achenbach, Chad J., Mayor, Angel M., and Althoff, Keri N.

Published
2018
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44. Integrated genomic characterization of oesophageal carcinoma

Author

Kim, Jihun, Bowlby, Reanne, Mungall, Andrew J., Robertson, Gordon A., Odze, Robert D., Cherniack, Andrew D., Shih, Juliann, Pedamallu, Chandra Sekhar, Cibulskis, Carrie, Dunford, Andrew, Meier, Samuel R., Kim, Jaegil, Raphael, Benjamin J., Wu, Hsin-Ta, Wong, Alexandra M., Willis, Joseph E., Bass, Adam J., Derks, Sarah, Garman, Katherine, McCall, Shannon J., Wiznerowicz, Maciej, Pantazi, Angeliki, Parfenov, Michael, Thorsson, Vésteinn, Shmulevich, Ilya, Dhankani, Varsha, Miller, Michael, Sakai, Ryo, Wang, Kenneth, Schultz, Nikolaus, Shen, Ronglai, Arora, Arshi, Weinhold, Nils, Sánchez-Vega, Francisco, Kelsen, David P., Zhang, Julia, Felau, Ina, Demchok, John, Rabkin, Charles S., Camargo, Constanza M., Zenklusen, Jean Claude, Bowen, Jay, Leraas, Kristen, Lichtenberg, Tara M., Curtis, Christina, Seoane, Jose A., Ojesina, Akinyemi I., Beer, David G., Gulley, Margaret L., Pennathur, Arjun, Luketich, James D., Zhou, Zhongren, Weisenberger, Daniel J., Akbani, Rehan, Lee, Ju-Seog, Liu, Wenbin, Mills, Gordon B., Zhang, Wei, Reid, Brian J, Hinoue, Toshinori, Laird, Peter W., Shen, Hui, Piazuelo, Blanca M., Schneider, Barbara G., McLellan, Michael, Taylor-Weiner, Amaro, Cibulskis, Carrie, Lawrence, Michael, Cibulskis, Kristian, Stewart, Chip, Getz, Gad, Lander, Eric, Gabriel, Stacey B., Ding, Li, McLellan, Michael D., Miller, Christopher A., Appelbaum, Elizabeth L., Cordes, Matthew G., Fronick, Catrina C., Fulton, Lucinda A., Mardis, Elaine R., Wilson, Richard K., Schmidt, Heather K., Fulton, Robert S., Ally, Adrian, Balasundaram, Miruna, Bowlby, Reanne, Carlsen, Rebecca, Chuah, Eric, Dhalla, Noreen, Holt, Robert A., Jones, Steven J. M., Kasaian, Katayoon, Brooks, Denise, Li, Haiyan I., Ma, Yussanne, Marra, Marco A., Mayo, Michael, Moore, Richard A., Mungall, Andrew J., Mungall, Karen L., Robertson, Gordon A., Schein, Jacqueline E., Sipahimalani, Payal, Tam, Angela, Thiessen, Nina, Wong, Tina, Cherniack, Andrew D., Shih, Juliann, Pedamallu, Chandra Sekhar, Beroukhim, Rameen, Bullman, Susan, Cibulskis, Carrie, Murray, Bradley A., Saksena, Gordon, Schumacher, Steven E., Gabriel, Stacey, Meyerson, Matthew, Hadjipanayis, Angela, Kucherlapati, Raju, Pantazi, Angeliki, Parfenov, Michael, Ren, Xiaojia, Park, Peter J., Lee, Semin, Kucherlapati, Melanie, Yang, Lixing, Baylin, Stephen B., Hoadley, Katherine A., Weisenberger, Daniel J., Bootwalla, Moiz S., Lai, Phillip H., Van Den Berg, David J., Berrios, Mario, Holbrook, Andrea, Akbani, Rehan, Hwang, Jun-Eul, Jang, Hee-Jin, Liu, Wenbin, Weinstein, John N., Lee, Ju-Seog, Lu, Yiling, Sohn, Bo Hwa, Mills, Gordon, Seth, Sahil, Protopopov, Alexei, Bristow, Christopher A., Mahadeshwar, Harshad S., Tang, Jiabin, Song, Xingzhi, Zhang, Jianhua, Laird, Peter W., Hinoue, Toshinori, Shen, Hui, Cho, Juok, Defrietas, Timothy, Frazer, Scott, Gehlenborg, Nils, Heiman, David I., Lawrence, Michael S., Lin, Pei, Meier, Samuel R., Noble, Michael S., Voet, Doug, Zhang, Hailei, Kim, Jaegil, Polak, Paz, Saksena, Gordon, Chin, Lynda, Getz, Gad, Wong, Alexandra M., Raphael, Benjamin J., Wu, Hsin-Ta, Lee, Semin, Park, Peter J., Yang, Lixing, Thorsson, Vésteinn, Bernard, Brady, Iype, Lisa, Miller, Michael, Reynolds, Sheila M., Shmulevich, Ilya, Dhankani, Varsha, Abeshouse, Adam, Arora, Arshi, Armenia, Joshua, Kundra, Ritika, Ladanyi, Marc, Lehmann, Kjong-Van, Gao, Jianjiong, Sander, Chris, Schultz, Nikolaus, Sánchez-Vega, Francisco, Shen, Ronglai, Weinhold, Nils, Chakravarty, Debyani, Zhang, Hongxin, Radenbaugh, Amie, Hegde, Apruva, Akbani, Rehan, Liu, Wenbin, Weinstein, John N., Chin, Lynda, Bristow, Christopher A., Lu, Yiling, Penny, Robert, Crain, Daniel, Gardner, Johanna, Curley, Erin, Mallery, David, Morris, Scott, Paulauskis, Joseph, Shelton, Troy, Shelton, Candace, Bowen, Jay, Frick, Jessica, Gastier-Foster, Julie M., Gerken, Mark, Leraas, Kristen M., Lichtenberg, Tara M., Ramirez, Nilsa C., Wise, Lisa, Zmuda, Erik, Tarvin, Katherine, Saller, Charles, Park, Young Soo, Button, Michael, Carvalho, Andre L., Reis, Rui Manuel, Matsushita, Marcus Medeiros, Lucchesi, Fabiano, de Oliveira, Antonio Talvane, Le, Xuan, Paklina, Oxana, Setdikova, Galiya, Lee, Jae-Hyuck, Bennett, Joseph, Iacocca, Mary, Huelsenbeck-Dill, Lori, Potapova, Olga, Voronina, Olga, Liu, Ouida, Fulidou, Victoria, Cates, Crystal, Sharp, Alexis, Behera, Madhusmitara, Force, Seth, Khuri, Fadio, Owonikoko, Taofeek, Pickens, Allan, Ramalingam, Suresh, Sica, Gabriel, Dinjens, Winand, van Nistelrooij, Anna, Wijnhoven, Bas, Sandusky, George, Stepa, Serghei, Crain, Daniel, Paulauskis, Joseph, Penny, Robert, Gardner, Johanna, Mallery, David, Morris, Scott, Shelton, Troy, Shelton, Candace, Curley, Erin, Juhl, Hartmut, Zornig, Carsten, Kwon, Sun Young, Kelsen, David, Kim, Hark Kyun, Bartlett, John, Parfitt, Jeremy, Chetty, Runjan, Darling, Gail, Knox, Jennifer, Wong, Rebecca, El-Zimaity, Haila, Liu, Geoffrey, Boussioutas, Alex, Park, Do Young, Kemp, Rafael, Carlotti, Carlos Gilberto, da Cunha Tirapelli, Daniela Pretti, Saggioro, Fabiano Pinto, Sankarankutty, Ajith Kumar, Noushmehr, Houtan, dos Santos, Jose Sebastião, Trevisan, Felipe Amstalden, Eschbacher, Jennifer, Dubina, Michael, Mozgovoy, Eugene, Carey, Frank, Chalmers, Sally, Forgie, Ian, Godwin, Andrew, Reilly, Colleen, Madan, Rashna, Naima, Zaid, Ferrer-Torres, Daysha, Vinco, Michele, Rathmell, Kimryn W., Dhir, Rajiv, Luketich, James, Pennathur, Arjun, Ajani, Jaffer A., McCall, Shannon J., Janjigian, Yelena, Kelsen, David, Ladanyi, Marc, Tang, Laura, Camargo, Constanza M., Ajani, Jaffer A., Cheong, Jae-Ho, Chudamani, Sudha, Liu, Jai, Lolla, Laxmi, Naresh, Rashi, Pihl, Todd, Sun, Qiang, Wan, Yunhu, Wu, Ye, Demchok, John A., Felau, Ina, Ferguson, Martin L., Shaw, Kenna R. Mills, Sheth, Margi, Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Zenklusen, Jean Claude, Hutter, Carolyn M., Sofia, Heidi J., and Zhang, Jiashan

Published
2017
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46. Antibodies Against Epstein–Barr Virus as Disease Markers of Gastric Cancer: A Systematic Review.

Author

Fontes-Lemus, José I., Zhao, Isaac, Rabkin, Charles S., and Fuentes-Pananá, Ezequiel M.

Subjects
EPSTEIN-Barr virus, EPSTEIN-Barr virus diseases, STOMACH cancer, GASTRIC diseases, TUMOR markers, VIRAL antibodies, IMMUNOGLOBULINS, EOSINOPHILIC granuloma
Abstract

Introduction: Gastric cancer is the fourth deadliest cancer worldwide. Due to the lack of specific early symptoms and noninvasive methods for early detection, the prognosis of gastric cancer patients is poor. Gastric cancer has a well-recognized infectious etiology, with Helicobacter pylori and Epstein–Barr Virus being the main associated infectious agents. Although other Epstein–Barr Virus-associated malignancies often manifest with abnormal levels of anti-Epstein–Barr Virus antibodies, it is not clear whether this is also true for gastric cancer. Potentially, these antibodies could serve as a noninvasive tool for gastric cancer screening or as markers for gastric cancer risk and provide a better understanding of the participation of Epstein–Barr Virus in the development of this neoplasm. Methods: We conducted a systematic review of articles analyzing anti-Epstein–Barr Virus serology in gastric cancer and precursor lesions following PRISMA guidelines. Patients were classified according to the Correa cascade of gastric lesions and whether they were positive or negative by EBER- in situ hybridization (Epstein–Barr Virus-associated gastric cancer and Epstein–Barr Virus-nonassociated gastric cancer, respectively). Results: We retrieved 16 articles involving 9735 subjects from 12 different countries and 4 databases, PubMed, SciELO, Scopus, and Google Scholar. Higher antibody titers were observed not only in Epstein–Barr Virus-associated gastric cancer than in Epstein–Barr Virus-nonassociated gastric cancer but also in Epstein–Barr Virus-nonassociated gastric cancer and gastric cancer–precursor lesions when compared with patients with mild dyspepsia or healthy controls. In all cases, the associations were predominantly with antibodies directed against lytic cycle antigens. Conclusion: Data support the role of Epstein–Barr Virus lytic reactivation in the development of advanced gastric lesions. However, more studies are needed to confirm these associations, particularly the association with lesions considered negative by EBER- in situ hybridization, and to establish a set of antibodies and thresholds indicative of enhanced risk to develop these lesions. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium.

Author

Collatuzzo, Giulia, Negri, Eva, Pelucchi, Claudio, Bonzi, Rossella, Turati, Federica, Rabkin, Charles S., Liao, Linda M., Sinha, Rashmi, Palli, Domenico, Ferraroni, Monica, López-Carrillo, Lizbeth, Lunet, Nuno, Morais, Samantha, Albanes, Demetrius, Weinstein, Stephanie J., Parisi, Dominick, Zaridze, David, Maximovitch, Dmitry, Dierssen-Sotos, Trinidad, and Jiménez-Moleón, José Juan

Abstract

Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium

Author

Martimianaki, Georgia Bertuccio, Paola Alicandro, Gianfranco and Pelucchi, Claudio Bravi, Francesca Carioli, Greta Bonzi, Rossella Rabkin, Charles S. Liao, Linda M. Sinha, Rashmi and Johnson, Ken Hu, Jinfu Palli, Domenico Ferraroni, Monica and Lunet, Nuno Morais, Samantha Tsugane, Shoichiro Hidaka, Akihisa Hamada, Gerson Shigueaki Lopez-Carrillo, Lizbeth and Hernandez-Ramirez, Raul Ulises Zaridze, David Maximovitch, Dmitry Aragones, Nuria Martin, Vicente Ward, Mary H. and Vioque, Jesus Garcia de la Hera, Manoli Zhang, Zuo-Feng and Kurtz, Robert C. Lagiou, Pagona Lagiou, Areti Trichopoulou, Antonia Karakatsani, Anna Malekzadeh, Reza Camargo, M. Constanza Curado, Maria Paula Boccia, Stefania Boffetta, Paolo Negri, Eva La Vecchia, Carlo

Abstract

Objective This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. Methods A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for coffee drinkers versus never or rare drinkers. A one-stage logistic mixed-effects model with a random intercept for each study was used to estimate the dose-response relationship. Estimates were adjusted for sex, age and the main recognized risk factors for gastric cancer. Results Compared to never or rare coffee drinkers, the estimated pooled OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of coffee intake was considered, the pooled ORs were 0.91 (95% CI, 0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10) for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven or more cups of caffeinated coffee per day). A positive association emerged for high coffee intake (five or more cups per day) for gastric cardia cancer only. Conclusions These findings better quantify the previously available evidence of the absence of a relevant association between coffee consumption and gastric cancer.

Published
2022

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