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580 results on '"RIZZELLO, F."'

1. Pouchitis: Clinical Features, Diagnosis, and Treatment

Author

Gionchetti P, Calabrese C, Laureti S, Poggioli G, and Rizzello F

Subjects
pouchitis, chronic antibiotic refractory pouchitis, classification, diagnosis, management, Medicine (General), R5-920
Abstract

Paolo Gionchetti, Carlo Calabrese, Silvio Laureti, Gilberto Poggioli, Fernando Rizzello IRCCS Azienda Ospedaliero-Universitaria di Bologna, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Bologna, ItaliaCorrespondence: Paolo GionchettiDIMEC, Via Massarenti 9, Bologna, 40138, ItaliaEmail paolo.gionchetti@unibo.itAbstract: Procto-colectomy with an ileal pouch anal anastomosis is the procedure of choice for ulcerative colitis patients that require colectomy. Pouchitis is a non-specific inflammation of the ileal reservoir, and the most common, inflammatory and long-term, complication after pouch surgery for ulcerative colitis. The aetiology is still unknown, but many risk factors have been individuated. Pouchitis can be classified based on aetiology, duration, clinical course, and response to antibiotic therapy. Accurate diagnosis and classification is the key factor for an adequate management, and exclusion of secondary causes of pouchitis is pivotal. Most of the patients consistently respond to antibiotic therapy, but management of the subgroup of patients with chronic-antibiotic-resistant-pouchitis is still challenging, being this entity one of the major causes of pouch failure.Keywords: pouchitis, chronic antibiotic refractory pouchitis, classification, diagnosis, management

Published
2021

3. Effectiveness and safety of vedolizumab in a matched cohort of elderly and nonelderly patients with inflammatory bowel disease: the IG-IBD LIVE study

Author

Pugliese, D., Privitera, G., Crispino, F., Mezzina, N., Castiglione, F., Fiorino, G., Laterza, L., Viola, A., Bertani, L., Caprioli, F., Cappello, M., Barberio, B., Ricci, C., Balestrieri, P., Daperno, M., Pluchino, D., Rizzello, F., Scribano, M. L., Sablich, R., Pastorelli, L., Manguso, F., Variola, A., Di Sario, A., Grossi, L., Armuzzi, A., Ribaldone, D. G., Biscaglia, G., Buda, A., Mocci, G., Viscido, A., Di Paolo, M. C., Onali, S., Rodino, S., Coletta, M., Principi, M., Miranda, A., Amato, A., Bezzio, C., Petruzzellis, C., Mazzuoli, S., Festa, S., Sartini, A., Checchin, D., Fanigliulo, L., Gallina, S., Cesarini, M., Bodini, G., Stradella, D., Spagnuolo, R., Guidi, L., Savarino, E., Scrivo, B., Soru, P., Costa, F., Fries, W., Scaldaferri, F., Allocca, M., Pellegrini, L., Massari, A., Orlando, A., Pugliese D., Privitera G., Crispino F., Mezzina N., Castiglione F., Fiorino G., Laterza L., Viola A., Bertani L., Caprioli F., Cappello M., Barberio B., Ricci C., Balestrieri P., Daperno M., Pluchino D., Rizzello F., Scribano M.L., Sablich R., Pastorelli L., Manguso F., Variola A., Di Sario A., Grossi L., Armuzzi A., Ribaldone D.G., Biscaglia G., Buda A., Mocci G., Viscido A., Di Paolo M.C., Onali S., Rodino S., Coletta M., Principi M., Miranda A., Amato A., Bezzio C., Petruzzellis C., Mazzuoli S., Festa S., Sartini A., Checchin D., Fanigliulo L., Gallina S., Cesarini M., Bodini G., Stradella D., Spagnuolo R., Guidi L., Savarino E., Scrivo B., Soru P., Costa F., Fries W., Scaldaferri F., Allocca M., Pellegrini L., Massari A., and Orlando A.

Subjects
Crohn’s disease, Ulcerative, Antibodies, Monoclonal, Humanized, biologics (IBD), immunosuppression, ulcerative colitis, Aged, Chronic Disease, Colitis, Ulcerative, Crohn Disease, Humans, Prospective Studies, Retrospective Studies, Treatment Outcome, Tumor Necrosis Factor Inhibitors, Gastrointestinal Agents, Inflammatory Bowel Diseases, Antibodies, Monoclonal, Pharmacology (medical), Humanized, Settore MED/12 - Gastroenterologia, Hepatology, Gastroenterology, Colitis
Abstract

Background: Vedolizumab registration trials were the first to include elderly patients with moderate-to-severe ulcerative colitis (UC) or Crohn’s disease (CD), but few real-life data have been reported in this population. Aims: We investigated the effectiveness and safety of vedolizumab in matched cohorts of elderly and nonelderly UC and CD patients. Methods: The Long-term Italian Vedolizumab Effectiveness (LIVE) study is a retrospective-prospective study including UC and CD patients who started vedolizumab from April 2016 to June 2017. Elderly patients (≥65 years) were matched clinically 1:2 to nonelderly patients (18–64 years); the 2 groups were followed until drug discontinuation or June 2019. Results: The study included 198 elderly (108 UC, 90 CD) and 396 matched nonelderly patients (205 UC, 191 CD). Nonelderly UC patients had a significantly higher persistence on vedolizumab compared to elderly patients (67.6% vs. 51.4%, p=0.02). No significant difference in effectiveness was observed between elderly and nonelderly CD patients (59.4% vs. 52.4%, p=0.32). Age ≥65 years was associated with lower persistence in UC; for CD, previous exposure to anti-TNF-α agents, Charlson comorbidity index >2 and moderate-to-severe clinical activity at baseline were associated with lower persistence. There were recorded 130 adverse events, with comparable rates between the two groups. A Charlson comorbidity index >2 was associated with an increased risk of adverse events. Conclusion: Vedolizumab can be considered a safe option in elderly IBD patients. Its effectiveness in elderly UC patients may be reduced, while no age-dependent effect on effectiveness was observed in CD.

Published
2022

9. Two years Two-year effectiveness and safety of golimumab in ulcerative colitis: An IG-IBD study

Author

Pugliese, D, Privitera, G, Rogai, F, Variola, A, Viola, A, Laterza, L, Privitera, Ac, Allocca, M, Bossa, F, Cappello, M, Daperno, M, Lorenzon, G, Mazzuoli, S, Principi, M, Sablich, R, Moser, L, Ferronato, A, Traini, S, Tapete, G, Bodini, G, Di Girolamo, M, Grossi, L, Mocci, G, Ricci, C, Saibeni, S, Festa, S, Spagnuolo, R, Cortelezzi, Cc, Mocciaro, F, Rizzello, F, Armuzzi, A, and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD

Subjects
remission, naïve, persistence, Golimumab, ulcerative colitis
Published
2021

11. Correction: PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability (Modern Pathology, (2020), 33, 7, (1398-1409), 10.1038/s41379-020-0497-0)

Author

Giuffrida, P., Arpa, G., Grillo, F., Klersy, C., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., D'Errico, A., Malvi, D., Mescoli, C., Rugge, M., Nesi, G., Ferrero, S., Furlan, D., Poggioli, G., Rizzello, F., Macciomei, M. C., Santini, D., Volta, U., De Giorgio, R., Caio, G., Calabro, A., Ciacci, C., D'Armiento, M., Rizzo, A., Solina, G., Martino, M., Tonelli, F., Villanacci, V., Cannizzaro, R., Canzonieri, V., Florena, A. M., Biancone, L., Monteleone, G., Caronna, R., Ciardi, A., Elli, L., Caprioli, F., Vecchi, M., D'Inca, R., Zingone, F., D'Odorico, A., Lenti, M. V., Oreggia, B., Bonetti, L. R., Astegiano, M., Biletta, E., Cantoro, L., Giannone, A. G., Orlandi, A., Papi, C., Perfetti, V., Quaquarini, E., Sandri, G., Silano, M., Usai, P., Barresi, V., Ciccocioppo, R., Luinetti, O., Pedrazzoli, P., Pietrabissa, A., Viglio, A., Paulli, M., Corazza, G. R., Solcia, E., Vanoli, A., and Di Sabatino, A.

Published
2020

14. Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis

Author

Kuhbacher, T., Ott, S.J., Helwig, U., Mimura, T., Rizzello, F., Kleessen, B., Gionchetti, P., Blaut, M., Campieri, M., Folsch, U.R., Kamm, M.A., and Schreiber, S.

Subjects
Probiotics -- Physiological aspects, Probiotics -- Research, Anastomosis -- Complications and side effects, Surgical anastomosis -- Complications and side effects, Ulcerative colitis -- Care and treatment, Health
Published
2006

15. Infliximab and newly diagnosed neoplasia in Crohn's disease: a multicentre matched pair study

Author

Biancone, L., Orlando, A., Kohn, A., Colombo, E., Sostegni, R., Angelucci, E., Rizzello, F., Castiglione, F., Benazzato, L., Papi, C., Meucci, G., Riegler, G., Petruzziello, C., Mocciaro, F., Geremia, A., Calabrese, E., Cottone, M., and Pallone, F.

Subjects
Infliximab -- Complications and side effects, Infliximab -- Research, Crohn's disease -- Drug therapy, Gastrointestinal tumors -- Risk factors, Health
Published
2006

17. Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis

Author

Mimura, T., Rizzello, F., Helwig, U., Poggioli, G., Schreiber, S., Talbot, I.C., Nicholls, R.J., Gionchetti, P., Campieri, M., and Kamm, M.A.

Subjects
Health
Abstract

Gut 2004;53:108-114 Background: Ten to 15% of patients with pouchitis experience refractory or recurrent disease. The aim of this study was to evaluate the effectiveness of a single daily high [...]

Published
2004

28. Pre-pouch ileitis

Author

CALABRESE, C., GIONCHETTI, P., RIZZELLO, F., LIGUORI, G., MORSELLI, C., POGGIOLI, G., and FEBO, G. DI

Published
2007

34. Microbiology

Author

Figura, N., Owen, R. J., Desai, M., Bayeli, P. F., HGregorio, L. Di, Russi, M., Musmanno, R. A., Hawtin, P. R., Sharpstone, D., Hayes, L., Nøorgaard, A., Nielsen, H., Andersen, L. P., Geis, G., Leying, H., Suerbaum, S., Opferkuch, W., Tonokatsu, Y., Hayashi, T., Fukuda, Y., Yamamoto, I., Takami, S., Tamura, T., Shimoyama, T., Lopez-Brea, M., Martin, E., C.Sanz, J., Alonso, M., Alarcon, T., Michetti, P., Porta, N., Racine, L., P.Kraehenbuhl, J., L.Blum, A., Cardeñoso, L., Moran, A. P., Muotiala, A., Pyhälä, L., Kosunen, T. U., Helander, I. M., Roine, R. P., Salmela, K. S., Höök-Nikanne, J., Salaspuro, M., Daw, M. A., Xia, H. X., O’Morain, C., Lelwala-Guruge, J., Ascencio, F., Ljungh, Å., Wadström, T., Ringnér, Martina, Valkonen, Kaija, Paulsson, Marianne, Ljungh, Åsa, Wadström, Torkel, Guldvog, I., Tannaes, T., Bukholm, G., Grav, H., Corinaldesi, R., Tucci, A., Stanghellini, V., Gasperoni, S., Varoli, O., Paparo, G. F., Gaetani, M., Cioffi, G., Barbara, L., Husson, M. O., Legrand, D., Mazurier, J., Caron, C., Leclerc, H., Spik, G., English, L., Keane, C. T., O’Morain, C. A., Fox, J. G., Correa, P., Taylor, N. S., Fatela, N., Melo Cristino, J., Monteiro, L., Ramalho, F., Saragoça, A., Salgado, M.J, Mauch, F., Bode, G., Ditschuneit, H., Malfertheiner, P., Nilius, M., Pugliese, M., Moshkowitz, M., Gorea, A., Santo, M., Berger, S., Gilat, T., Belluzzi, A., Vaira, D., Campieri, M., Boschi, S., Gionchetti, P., Mulè, P., Brignola, C., Rizzello, F., Miglioli, M., Barbara, L., Lamouliatte, H., Brugmann, D., Cayla, R., H. Bernard, P., Mégraud, F., Quinton, A., Bär, W., Wagner, S., Glen-Calvo, E., Koopmann, H., Szentmihalyi, A., Radnai, Z., Molnar, Gy., Bálint, A., and Ihász, M.

Published
1992
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