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La captación miocárdica en la gammagrafía ósea se ha convertido en un método útil para la detección de la amiloidosis cardiaca secundaria al depósito de transtirretina (ATTR-CA). El objetivo de este estudio fue evaluar la prevalencia de captación miocárdica en pacientes mayores de 18 años sin sospecha clínica de amiloidosis cardiaca (AC) y a los que se realizó una gammagrafía ósea. Se trata de un estudio observacional, retrospectivo y multicéntrico realizado en 21 hospitales de España (de septiembre a noviembre de 2019). De las 9.864 gammagrafías analizadas (de forma local y central), en 71 pacientes (0,72%), se observó captación cardiaca incidental, con una prevalencia que aumentó con la edad. En el 16,9% de los pacientes con captación positiva se detectó un diagnóstico previo de insuficiencia cardiaca (IC), con > 50% de los pacientes en un grado II de la clasificación de la NYHA. En 10 pacientes se realizó el diagnóstico de ATTR-CA, con un retraso medio de 10,4 meses (IC 95%: 5,1-15,7). Todos ellos eran mayores de 70 años, principalmente varones y presentaban una mayor hipertrofia ventricular izquierda (HVI) respecto a los pacientes sin diagnóstico confirmado (p < 0,0001). Los pacientes con ATTR-CA presentaron una mayor tasa de hipotensión ortostática (30,0% vs. 3,8% en los pacientes sin ATTR-CA; p = 0,025). Se trata del primer estudio retrospectivo, de ámbito nacional y multicéntrico que evalúa la prevalencia de captación cardiaca incidental en gammagrafías óseas realizadas por motivos extracardiacos, y que muestra una prevalencia del 0,72% en esta población. La derivación de estos pacientes puede facilitar el diagnóstico precoz de la AC con el consiguiente beneficio para los mismos. Myocardial uptake on bone scintigraphy has become useful for the detection of transthyretin cardiac amyloidosis (ATTR-CA). This study aimed to assess the prevalence of myocardial uptake in patients over 18 years of age with no clinical suspicion of cardiac amyloidosis (CA) who had undergone bone scintigraphy. This was an observational, retrospective, multicenter study across 21 Spanish hospitals (September–November 2019). Of the 9864 scans analyzed (locally and centrally), incidental cardiac uptake was observed in 71 patients (0.72%), a prevalence that increased with age. A previous diagnosis of heart failure was found in 16.9% of patients with positive uptake, with >50% in NYHA II. ATTR-CA was diagnosed in 10 patients, with a mean delay of 10.4 months (95% CI: 5.1-15.7). All were >70 years old, primarily male, and had greater left ventricular hypertrophy than patients without a confirmed diagnosis (p < 0.0001). ATTR-CA patients had higher rates of orthostatic hypotension (30.0% vs. 3.8% in non-ATTR-CA; p = 0.025). This is the first retrospective, national, multicenter study evaluating the prevalence of incidental cardiac uptake in bone scintigraphy performed for non-cardiac reasons, showing a prevalence of 0.72% in this population. Referral of these patients may facilitate early diagnosis of CA with a resulting benefit for patients. [ABSTRACT FROM AUTHOR]

Electroencephalography (EEG) signal analysis is a fast, inexpensive, and accessible technique to detect the early stages of dementia, such as Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD). In the last years, EEG signal analysis has become an important topic of research to extract suitable biomarkers to determine the subject’s cognitive impairment. In this work, we propose a novel simple and efficient method able to extract features with a finite response filter (FIR) in the double time domain in order to discriminate among patients affected by AD, MCI, and healthy controls (HC). Notably, we compute the power intensity for each high- and low-frequency band, using their absolute differences to distinguish among the three classes of subjects by means of different supervised machine learning methods. We use EEG recordings from a cohort of 105 subjects (48 AD, 37 MCI, and 20 HC) referred for dementia to the IRCCS Centro Neurolesi “Bonino-Pulejo” of Messina, Italy. The findings show that this method reaches 97%, 95%, and 83% accuracy when considering binary classifications (HC vs. AD, HC vs. MCI, and MCI vs. AD) and an accuracy of 75% when dealing with the three classes (HC vs. AD vs. MCI). These results improve upon those obtained in previous studies and demonstrate the validity of our approach. Finally, the efficiency of the proposed method might allow its future development on embedded devices for low-cost real-time diagnosis.

Background: Variant transthyretin amyloidosis (ATTRv) is a rare multisystemic disorder caused by mutations in the transthyretin (TTR) gene. The aim of the present work was to describe the clinical profile of asymptomatic carriers (AC) and Coutinho stage 1 ATTRv patients in Spain., Methods: National, multicentre, cross-sectional study that included 86 AC and 19 patients diagnosed in the previous 12 months to enrolment. Clinical and demographical data, TTR gene mutations, red flags anamnesis, neurological and cardiological assessments were collected., Results: The mean age of patients was 56.8 years at onset and 58.6 years at diagnosis; 53% of patients and 51% of AC were from non-endemic areas. Val50Met was the most frequent mutation in both groups. Neuropathy impairment score data (mean 17.7 ± 20.5) and small-fibre function in lower limbs assessed with SUDOSCAN revealed that patients were diagnosed at early stages of neurological impairment. Peripheral polyneuropathy (84.2%), autonomic neuropathy (73.7%), cardiac (63.2%) and gastrointestinal (47.4%) alterations were the most common symptoms in patients. Autonomic neuropathy, gastrointestinal impairment, carpal tunnel syndrome, cardiac and ocular alterations were potentially related to ATTRv in the AC group., Conclusions: The EMPATIa study provides a detailed description of AC and Coutinho stage 1 ATTRv patients across Spain, confirming the multisystemic clinical profile of the disease. This study reveals a diagnosis delay around 1.8 years, highlighting the importance of a profound disease awareness to reach a diagnose in earlier stages of neurological impairment., (© 2024. The Author(s).)

Aim: Myocardial uptake on bone scintigraphy has become useful for the detection of transthyretin cardiac amyloidosis (ATTR-CA). This study aimed to assess the prevalence of myocardial uptake in patients over 18 years of age with no clinical suspicion of cardiac amyloidosis (CA) who had undergone bone scintigraphy., Methods and Results: This was an observational, retrospective, multicenter study across 21 Spanish hospitals (September-November 2019). Of the 9864 scans analyzed (locally and centrally), incidental cardiac uptake was observed in 71 patients (0.72%), a prevalence that increased with age. A previous diagnosis of heart failure was found in 16.9% of patients with positive uptake, with >50% in NYHA II. ATTR-CA was diagnosed in 10 patients, with a mean delay of 10.4 months (95% CI: 5.1-15.7). All were >70 years old, primarily male, and had greater left ventricular hypertrophy than patients without a confirmed diagnosis (p<0.0001). ATTR-CA patients had higher rates of orthostatic hypotension (30.0% vs. 3.8% in non-ATTR-CA; p=0.025)., Conclusions: This is the first retrospective, national, multicenter study evaluating the prevalence of incidental cardiac uptake in bone scintigraphy performed for non-cardiac reasons, showing a prevalence of 0.72% in this population. Referral of these patients may facilitate early diagnosis of CA with a resulting benefit for patients., (Copyright © 2024 The Author(s). Published by Elsevier España, S.L.U. All rights reserved.)

Background: Continuity of care, a concept that in its broadest terms describes patient and provider coordination across time and settings, has evidenced a positive correlation with patient satisfaction and hospital readmission rates. Home health care, where patients receive care from a variety of healthcare practitioners, is one area where these measures are being investigated to determine the effectiveness of continuity of care., Objective: To examine and synthesize the best available evidence related to the effectiveness of continuity of care interventions and their impact on patient satisfaction and all-cause hospital readmissions rates in the adult patient who is receiving home care services., Inclusion Criteria: Male and female aged 18 years or older receiving home care services, regardless of diagnosis, stage or severity of disease, co-morbidities, or previous treatment received.All types and models of interventions for continuity of care delivered by nurses to patients receiving home care services were considered for inclusion in the review.Patient satisfaction and hospital readmissions.In this review randomised controlled trials were considered for inclusion. In their absence, other research designs, such as non-randomised controlled trials, quasi-experimental studies, and before and after studies were considered for inclusion., Search Strategy: Published and unpublished literature in the English language was sought from the inception of the databases through November 1, 2011.The databases searched included: Academic Search Premier, CINAHL ERIC, Health Reference Center Academic, MEDLINE via PubMed, ProQuest Nursing and Allied Health Source, ProQuest Health Management, Cochrane Central Register of Controlled Trials, EMBASE, Health Source Nursing Academic, PsycINFO and Bio-Med. A search of the grey literature and virtual hand searching of relevant journals was also performed., Methodological Quality: Two reviewers evaluated the included studies for methodological quality using standardised critical appraisal instruments from the Joanna Briggs Institute., Data Collection: Data were extracted using standardised data extraction instruments from the Joanna Briggs Institute., Data Synthesis: Statistical pooling via meta-analysis was not possible. The results are presented in narrative form., Results: Two randomised controlled trails and two quasi-experimental studies were included in this review. In one randomised controlled trial, 66% of patients rated their overall satisfaction with care as very good or excellent as compared with 63% of those receiving usual care at 24 months (p=0.31). Another randomised controlled trial reported no statistically significant difference between groups (p value not reported). In one quasi-experimental study there was higher satisfaction rate amongst intervention patients with a mean difference of 16.88 (95%CI[16.32, 17.43] compared with 14.65 (95%CI[13.61, 15.68] in the control group (p=0.001).In one randomised controlled trial there was no statistically significant difference between intervention and control groups in hospital admission rates per 1000 at year two (700 vs. 740; p=0.66). Another randomised controlled trial showed no difference in readmissions at 90 days between groups (36% vs. 35%; no p value reported). In one quasi-experimental study, the mean number of hospital readmissions per patient was higher in the intervention group compared to the control group (0.75; 95% CI[ 0.47, 1.03] vs. 0.66; 95% CI[ 0.40, 0.91]; p=0.599), In another quasi-experimental study, a statistically significant higher number of intervention group patients in the intervention group were discharged and remained at home (34 or 82.9%), compared to the control group (20 or 51.3%) (p<0.05)., Conclusions: Home care interventions that include nurses and advanced practice nurses with specialised training in the care of the population served as the direct provider along with collaboration with an interdisciplinary team in a high-risk patient populations contributed to reduced hospital readmission rates. The outcomes of the included studies suggest that consistently scheduled home care services promote patient satisfaction.This review concluded that the utilisation of an advanced practice nurse with specialised training in a specific disease process in collaboration with a multidisciplinary team can affect readmission rates and patient satisfaction.Further research is needed that captures a diverse patient population in terms of age and illness and the role that an advanced practice nurse can play.