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6. Associations between neighborhood socioeconomic deprivation, IFNγ, and high-density lipoprotein particle size: Data from the Washington, D.C. cardiovascular health and needs assessment

Author

Ortiz-Whittingham, Lola R., Baumer, Yvonne, Pang, Alina P.S., Sampson, Maureen, Baez, Andrew S., Rose, Raviv, Noonan, Sarah H., Mendez-Silva, Joanna, Collins, Billy S., Mitchell, Valerie M., Cintron, Manuel A., Farmer, Nicole, Remaley, Alan T., Corley, Michael J., and Powell-Wiley, Tiffany M.

Published
2023
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7. A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association

Author

Ndumele, Chiadi E., Neeland, Ian J., Tuttle, Katherine R., Chow, Sheryl L., Mathew, Roy O., Khan, Sadiya S., Coresh, Josef, Baker-Smith, Carissa M., Carnethon, Mercedes R., Després, Jean-Pierre, Ho, Jennifer E., Joseph, Joshua J., Kernan, Walter N., Khera, Amit, Kosiborod, Mikhail N., Lekavich, Carolyn L., Lewis, Eldrin F., Lo, Kevin B., Ozkan, Bige, Palaniappan, Latha P., Patel, Sonali S., Pencina, Michael J., Powell-Wiley, Tiffany M., Sperling, Laurence S., Virani, Salim S., Wright, Jackson T., Rajgopal Singh, Radhika, Elkind, Mitchell S.V., and Rangaswami, Janani

Published
2023
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8. Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association

Author

Ndumele, Chiadi E., Rangaswami, Janani, Chow, Sheryl L., Neeland, Ian J., Tuttle, Katherine R., Khan, Sadiya S., Coresh, Josef, Mathew, Roy O., Baker-Smith, Carissa M., Carnethon, Mercedes R., Despres, Jean-Pierre, Ho, Jennifer E., Joseph, Joshua J., Kernan, Walter N., Khera, Amit, Kosiborod, Mikhail N., Lekavich, Carolyn L., Lewis, Eldrin F., Lo, Kevin B., Ozkan, Bige, Palaniappan, Latha P., Patel, Sonali S., Pencina, Michael J., Powell-Wiley, Tiffany M., Sperling, Laurence S., Virani, Salim S., Wright, Jackson T., Rajgopal Singh, Radhika, and Elkind, Mitchell S.V.

Published
2023
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9. Abstract 18248: Physical Activity and Nutrition Self-Efficacy Associates With Perceived Everyday Discrimination in African American Women: The Step It Up Physical Activity Intervention

Author

Osei Baah, Foster, Baumer, Yvonne, Tarfa, Hannatu, Dave, Ayushi, Pita, Mario, Cintron, Manuel A., Ortiz-Whittingham, Lola, Reynolds, Sandy, Abhinav Saurabh, Fnu, Kameswari, Potharaju, Baez, Andrew, Thompson, Keitra, Ayers, Colby, Neally, Sam, Curlin, Kaveri, Vijayakumar, Nithya, Mitchell, Valerie, Wells, Ayanna, Marah, Marie, Collins, Billy, Dodge, Tonya, Wallen, Gwenyth, and Powell-Wiley, Tiffany M

Published
2023
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11. Abstract 17627: The Relationship Between Physical Activity, Extracellular Vesicles, and Diabetes Risk in African American Women at Risk for Cardiovascular Disease: Data From a Pilot Study of the Step It Up Physical Activity Intervention

Author

Dobrian, Anca, Miller, Noel, Bavuso, Matthew, Vijayakumar, Nithya, Neally, Sam, Collins, Billy, Potharaju, Kameswari, Ceasar, Joniqua, Curlin, Kaveri, Andrews, Marcus, Turner, Briana, Gutierrez-Huerta, Cristhian, Troendle, James, Mitchell, Valerie, Sampson, Maureen, Remaley, Alan, Baumer, Yvonne, and Powell-Wiley, Tiffany M

Published
2023
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12. Abstract 14087: Physical Activity is Associated With Monocytes and Monocyte Subsets in Low-Resourced Neighborhoods: Data From the Step It Up Physical Activity Intervention

Author

Saurabh, Abhinav, Tarfa, Hannatu, Baumer, Yvonne, Dave, Ayushi, Pita, Mario, Cintron, Manuel, Ortiz-Whittingham, Lola, Reynolds, Sandy, Potharaju, Kameswari, Baez, Andrew, Thompson, Keitra, Osei Baah, Foster, Ayers, Colby, Neally, Sam, Curlin, Kaveri, Vijayakumar, Nithya, Mitchell, Valerie, Wells, Ayanna, Marah, Marie, Collins, Billy, and Powell-Wiley, Tiffany M

Published
2023
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13. Abstract 14051: The Associations Between Loneliness and Circulating Lipoproteins as Well as Diabetes Risk in African-American Women Residing in Resource-Limited Neighborhoods: Data From the Step It Up Physical Activity Intervention

Author

Reynolds, Sandy, Baumer, Yvonne, Dave, Ayushi, Cintron, Manuel, Tarfa, Hannatu, Pita, Mario, Ortiz-Whittingham, Lola, Potharaju, Kameswari, Baez, Andrew, Thompson, Keitra, Osei Baah, Foster, Ayers, Colby, Neally, Sam, Curlin, Kaveri, Vijayakumar, Nithya, Mitchell, Valerie, Marah, Marie, Collins, Billy, Saurabh, Abhinav, Sampson, Maureen, Remaley, Alan, and Powell-Wiley, Tiffany M

Published
2023
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14. Abstract 13999: The Relationship Between Neighborhood Deprivation, Diabetes, and Extracellular Vesicles in African American Women at Risk for CVD: Data From a Pilot Study of the Step It Up Physical Activity Intervention

Author

Baumer, Yvonne, Miller, Noel, Bavuso, Matthew, Vijayakumar, Nithya, Neally, Sam, Potharaju, Kameswari, Ceasar, Joniqua N, Curlin, Kaveri, Andrews, Marcus, Turner, Briana, Gutierrez Huerta, Cristhian, Troendle, James, Mitchell, Valerie, Collins, Billy, Sampson, Maureen, Remaley, Alan, Dobrian, Anca, and Powell-Wiley, Tiffany M

Published
2023
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20. Relationships between neighborhood disadvantage and cardiovascular findings at autopsy in subjects with sudden death

Author

Cornelissen, Anne, Guo, Liang, Neally, Sam J., Kleinberg, Leah, Forster, Ashley, Nair, Rajeev, Gadhoke, Neel, Ghosh, Saikat Kumar B., Sakamoto, Atsushi, Sato, Yu, Kawakami, Rika, Mori, Masayuki, Kawai, Kenji, Fernandez, Raquel, Dikongue, Armelle, Abebe, Biniyam, Kutys, Robert, Romero, Maria E., Kolodgie, Frank D., Baumer, Yvonne, Powell-Wiley, Tiffany M., Virmani, Renu, and Finn, Aloke V.

Published
2023
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25. Abstract 13995: Relationships Between Neighborhood Disadvantage and Cardiovascular Findings at Autopsy in Subjects With Sudden Death

Author

Cornelissen, Anne, Guo, Liang, Neally, Sam J, Kleinberg, Leah, Forster, Ashley, Nair, Rajeev, Gadhoke, Neel, Ghosh, Saikat, Sakamoto, Atsushi, Sato, Yu, Kawakami, Rika, Mori, Masayuki, Kawai, Kenji, Fernandez, Raquel, Dikongue, Armelle, Abebe, biniyam, Kutys, Robert, Romero, Maria, Kolodgie, Frank D, Baumer, Yvonne, Powell-Wiley, Tiffany M, Virmani, Renu, and Finn, Aloke

Published
2022
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29. Characterization of PCSK9 in the Blood and Skin of Psoriasis

Author

Garshick, Michael S., Baumer, Yvonne, Dey, Amit K., Grattan, Ryan, Ng, Qimin, Teague, Heather L., Yu, Zu-Xi, Chen, Marcus Y., Tawil, Michael, Barrett, Tessa J., Underberg, James, Fisher, Edward A., Krueger, James, Powell-Wiley, Tiffany M., Playford, Martin P., Berger, Jeffrey S., and Mehta, Nehal N.

Published
2021
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30. Relationship between chronic stress-related neural activity, physiological dysregulation and coronary artery disease in psoriasis: Findings from a longitudinal observational cohort study

Author

Lateef, Sundus S., Al Najafi, Mina, Dey, Amit K., Batool, Mariyam, Abdelrahman, Khaled M., Uceda, Domingo E., Reddy, Aarthi S., Svirydava, Maryia D., Nanda, Navya, Ortiz, Jenis E., Prakash, Nina, Rodante, Justin A., Keel, Andrew, Zhou, Wunan, Chen, Marcus Y., Playford, Martin P., Teague, Heather L., Tawakol, Ahmed A., Gelfand, Joel M., Powell-Wiley, Tiffany M., and Mehta, Nehal N.

Published
2020
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31. Demographic trends of cardiorenal and heart failure deaths in the United States, 2011–2020.

Author

Shearer, Joseph J., Hashemian, Maryam, Nelson, Robert G., Looker, Helen C., Chamberlain, Alanna M., Powell-Wiley, Tiffany M., Pérez-Stable, Eliseo J., and Roger, Véronique L.

Subjects
HEART failure, CARDIO-renal syndrome, RACE, AGE groups, NOSOLOGY
Abstract

Background: Heart failure (HF) and kidney disease frequently co-occur, increasing mortality risk. The cardiorenal syndrome results from damage to either the heart or kidney impacting the other organ. The epidemiology of cardiorenal syndrome among the general population is incompletely characterized and despite shared risk factors with HF, differences in mortality risk across key demographics have not been well described. Thus, the primary goal of this study was to analyze annual trends in cardiorenal-related mortality, evaluate if these trends differed by age, sex, and race or ethnicity, and describe these trends against a backdrop of HF mortality. Methods and findings: The Centers for Disease Control and Prevention Wide-ranging ONline Data for Epidemiologic Research database was used to examine cardiorenal- and HF-related mortality in the US between 2011and 2020. International Classification of Diseases, 10 Revision codes were used to classify cardiorenal-related deaths (I13.x) and HF-related deaths (I11.0, I13.0, I13.2, and I50.x), among decedents aged 15 years or older. Decedents were further stratified by age group, sex, race, or ethnicity. Crude and age-adjusted mortality rates (AAMR) per 100,000 persons were calculated. A total of 97,135 cardiorenal-related deaths and 3,453,655 HF-related deaths occurred. Cardiorenal-related mortality (AAMR, 3.26; 95% CI: 3.23–3.28) was significantly lower than HF-related mortality (AAMR, 115.7; 95% CI: 115.6–115.8). The annual percent change (APC) was greater and increased over time for cardiorenal-related mortality (2011–2015: APC, 7.1%; 95% CI: 0.7–13.9%; 2015–2020: APC, 19.7%, 95% CI: 16.3–23.2%), whereas HF-related mortality also increased over that time period, but at a consistently lower rate (2011–2020: APC, 2.4%; 95% CI: 1.7–3.1%). Mortality was highest among older and male decedents for both causes. Cardiorenal-related deaths were more common in non-Hispanic or Latino Blacks compared to Whites, but similar rates were observed for HF-related mortality. A larger proportion of cardiorenal-related deaths, compared to HF-related deaths, listed cardiorenal syndrome as the underlying cause of death (67.0% vs. 1.2%). Conclusions: HF-related deaths substantially outnumber cardiorenal-related deaths; however, cardiorenal-related deaths are increasing at an alarming rate with the highest burden among non-Hispanic or Latino Blacks. Continued surveillance of cardiorenal-related mortality trends is critical and future studies that contain detailed biomarker and social determinants of health information are needed to identify mechanisms underlying differences in mortality trends. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Propionate functions as a feeding state–dependent regulatory metabolite to counter proinflammatory signaling linked to nutrient load and obesity.

Author

Han, Kim, Meadows, Allison M, Rodman, Matthew J, Russo, Anna Chiara, Sharma, Rahul, Singh, Komudi, Hassanzadeh, Shahin, Dagur, Pradeep K, Huffstutler, Rebecca D, Krause, Fynn N, Griffin, Julian L, Baumer, Yvonne, Powell-Wiley, Tiffany M, and Sack, Michael N

Subjects
SHORT-chain fatty acids, MONONUCLEAR leukocytes, T helper cells, PROPIONATES, G protein coupled receptors, DEACETYLATION
Abstract

Generally, fasting and refeeding confer anti- and proinflammatory effects, respectively. In humans, these caloric-load interventions function, in part, via regulation of CD4+ T cell biology. However, mechanisms orchestrating this regulation remain incomplete. We employed integrative bioinformatics of RNA sequencing and high-performance liquid chromatography–mass spectrometry data to measure serum metabolites and gene expression of peripheral blood mononuclear cells isolated from fasting and refeeding in volunteers to identify nutrient-load metabolite-driven immunoregulation. Propionate, a short chain fatty acid (SCFA), and the SCFA-sensing G protein–coupled receptor 43 (ffar2) were coordinately and inversely regulated by fasting and refeeding. Propionate and free fatty acid receptor agonists decreased interferon-γ and interleukin-17 and significantly blunted histone deacetylase activity in CD4+ T cells. Furthermore, propionate blunted nuclear factor κB activity and diminished interleukin-6 release. In parallel, propionate reduced phosphorylation of canonical T helper 1 (TH1) and TH17 regulators, STAT1 and STAT3, respectively. Conversely, knockdown of free fatty acid receptors significantly attenuated the anti-inflammatory role of propionate. Interestingly, propionate recapitulated the blunting of CD4+ TH cell activation in primary cells from obese individuals, extending the role of this metabolite to a disease associated with low-grade inflammation. Together, these data identify a nutrient-load responsive SCFA–G protein–coupled receptor linked pathway to regulate CD4+ TH cell immune responsiveness. Propionate blunts T helper cell responsiveness. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Assessing Acceptability: The Role of Understanding Participant, Neighborhood, and Community Contextual Factors in Designing a Community-Tailored Cooking Intervention.

Author

Farmer, Nicole, Tuason, Ralph, Middleton, Kimberly R., Ude, Assumpta, Tataw-Ayuketah, Gladys, Flynn, Sharon, Kazmi, Narjis, Baginski, Alyssa, Mitchell, Valerie, Powell-Wiley, Tiffany M., and Wallen, Gwenyth R.

Abstract

Background: Cooking is an identified dietary strategy that is positively associated with optimal diet quality. Prior to initiating cooking interventions, evaluating the prospective acceptability of the intervention among community members living within low food access areas and understanding geospatial food shopping locations may aid in designing community-tailored interventions. Methods: A sequential mixed methods study was conducted to determine the prospective acceptability of a planned community-located cooking intervention among African American adults living in a low food access area and with at least one cardiovascular disease risk factor. A semi-structured guide was used to conduct five virtual focus groups. Qualitative data were analyzed using thematic analysis and validated through participant check-in interviews. Survey responses were analyzed based on descriptive data. Geospatial analysis of participant locations that were reported for food shopping was conducted to show food environment utilization. Results: Focus groups with study participants (n = 20, all female, mean age 60.3, SD 9.3, mean cooking frequency per week 4.0, food insecure n = 7) were conducted between March and April, 2021. Thematic analysis of the focus group transcripts identified five main themes as follows: (A) Barriers to Cooking (family and caregiving, transportation, COVID-19 pandemic, time availability, household composition); (B) Motivators for Cooking (family, caregiving, health, enjoyment, COVID-19 pandemic); (C) Strategies (food shopping, social support, social media, meal planning); (D) Neighborhood (gentrification, perceived safety, stigmatization, disparities in grocery stores); (E) and Acceptability of the Intervention (reasons to participate, barriers, recruitment, intervention delivery). Participant validation interviews confirmed the themes and subthemes as well as the illustrative quotes. Geospatial analysis showed a majority of locations were outside of the participants' residential areas. Conclusions: Prospective acceptability of a community-tailored cooking intervention found that the planned intervention could be modified to address individual level factors, such as caregiving and health, community contextual factors, such as perceived safety, and the general health needs of the community. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Association of neighborhood gentrification with prostate cancer and immune markers in African American and European American me.

Author

Pichardo, Catherine M., Ezeani, Adaora, Pichardo, Margaret S., Agurs-Collins, Tanya, Powell-Wiley, Tiffany M., Ryan, Brid, Minas, Tsion Zewdu, Bailey-Whyte, Maeve, Wei Tang, Dorsey, Tiffany H., Wooten, William, Loffredo, Christopher A., and Ambs, Stefan

Subjects
GENTRIFICATION, PROSTATE cancer, BIOMARKERS, TUMOR markers, AFRICAN Americans, DISEASE risk factors
Abstract

Background: Prior studies showed that neighborhood deprivation increases the risk of lethal prostate cancer. However, the role of neighborhood gentrification in prostate cancer development and outcome remains poorly understood. We examined the relationships of gentrification with prostate cancer and serum proteomedefined inflammation and immune function in a diverse cohort. Methods: The case–control study included 769 cases [405 African American (AA), 364 European American (EA) men] and 1023 controls (479 AA and 544 EA), with 219 all-cause and 59 prostate cancer-specific deaths among cases. Geocodes were linked to a neighborhood gentrification index (NGI) derived from US Census data. Cox and logistic regression, and MANOVA, were used to determine associations between NGI, as continuous or quintiles (Q), and outcomes. Results: Adjusting for individual socioeconomic status (SES), continuous NGI was positively associated with prostate cancer among all men (odds ratio [OR] 1.07, 95% confidence interval [CI] 1.01–1.14). AA and low-income men experienced the highest odds of prostate cancer when residing in tracts with moderate gentrification, whereas EA men experienced reduced odds of regional/metastatic cancer with increased gentrification in SES-adjusted analyses. Continuous NGI also associated with mortality among men presenting with localized disease and low-income men in SES-adjusted Cox regression analyses. NGI was not associated with serum proteome-defined chemotaxis, inflammation, and tumor immunity suppression. Conclusions: Findings show that neighborhood gentrification associates with prostate cancer and mortality in this diverse population albeit associations were heterogenous within subgroups. The observations suggest that changing neighborhood socioeconomic environments may affect prostate cancer risk and outcome, likely through multifactorial mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Examining relationships between perceptions and objective assessments of neighborhood environment and sedentary time: Data from the Washington, D.C. Cardiovascular Health and Needs Assessment

Author

Ahuja, Chaarushi, Ayers, Colby, Hartz, Jacob, Adu-Brimpong, Joel, Thomas, Samantha, Mitchell, Valerie, Peters-Lawrence, Marlene, Sampson, Dana, Brooks, Alyssa T., Wallen, Gwenyth, Johnson, Allan, Graham, Lennox, Graham, Avis, Rivers, Joshua, Yingling, Leah, and Powell-Wiley, Tiffany M.

Published
2018
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41. A community feasibility study of a cooking behavior intervention in African-American adults at risk for cardiovascular disease: DC COOKS (DC Community Organizing for Optimal culinary Knowledge Study) with Heart

Author

Farmer, Nicole, Powell-Wiley, Tiffany M., Middleton, Kimberly R., Roberson, Brenda, Flynn, Sharon, Brooks, Alyssa T., Kazmi, Narjis, Mitchell, Valerie, Collins, Billy, Hingst, Rachel, Swan, Lucy, Yang, Shanna, Kakar, Seema, Harlan, Timothy, and Wallen, Gwenyth R.

Published
2020
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45. Immune cell phenotyping in low blood volumes for assessment of cardiovascular disease risk, development, and progression: a pilot study

Author

Baumer, Yvonne, Gutierrez-Huerta, Cristhian A., Saxena, Ankit, Dagur, Pradeep K., Langerman, Steven D., Tamura, Kosuke, Ceasar, Joniqua N., Andrews, Marcus R., Mitchell, Valerie, Collins, Billy S., Yu, Quan, Teague, Heather L., Playford, Martin P., Bleck, Christopher K. E., Mehta, Nehal N., McCoy, J. Philip, and Powell-Wiley, Tiffany M.

Published
2020
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46. New insights in the mechanisms of weight‐loss maintenance: Summary from a Pennington symposium.

Author

Flanagan, Emily W., Spann, Redin, Berry, Sarah E., Berthoud, Hans‐Rudolf, Broyles, Stephanie, Foster, Gary D., Krakoff, Jonathan, Loos, Ruth J. F., Lowe, Michael R., Ostendorf, Danielle M., Powell‐Wiley, Tiffany M., Redman, Leanne M., Rosenbaum, Michael, Schauer, Philip R., Seeley, Randy J., Swinburn, Boyd A., Hall, Kevin, and Ravussin, Eric

Subjects
WEIGHT loss, WEIGHT gain, CORONARY disease, TYPE 2 diabetes, DRUG therapy
Abstract

Obesity is a chronic disease that affects more than 650 million adults worldwide. Obesity not only is a significant health concern on its own, but predisposes to cardiometabolic comorbidities, including coronary heart disease, dyslipidemia, hypertension, type 2 diabetes, and some cancers. Lifestyle interventions effectively promote weight loss of 5% to 10%, and pharmacological and surgical interventions even more, with some novel approved drugs inducing up to an average of 25% weight loss. Yet, maintaining weight loss over the long‐term remains extremely challenging, and subsequent weight gain is typical. The mechanisms underlying weight regain remain to be fully elucidated. The purpose of this Pennington Biomedical Scientific Symposium was to review and highlight the complex interplay between the physiological, behavioral, and environmental systems controlling energy intake and expenditure. Each of these contributions were further discussed in the context of weight‐loss maintenance, and systems‐level viewpoints were highlighted to interpret gaps in current approaches. The invited speakers built upon the science of obesity and weight loss to collectively propose future research directions that will aid in revealing the complicated mechanisms involved in the weight‐reduced state. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Associations of Cumulative Perceived Stress with Cardiovascular Risk Factors and Outcomes: Findings from The Dallas Heart Study

Author

Eleazu, Ijeoma, Ayers, Colby, Navar, Ann Marie, Salhadar, Karim, Albert, Michele, Carnethon, Mercedes, Brown, Sherwood, Nwobodo, Lucy Ogbu, Carter, Spencer, Bess, Courtney, Powell-Wiley, Tiffany M., and de Lemos, James A.

Subjects
Article
Abstract

BACKGROUND: Data remain sparse regarding the impact of chronic stress on cardiovascular disease (CVD) risk factors and outcomes. Prior work has been limited by incomplete assessments of perceived stress and focus on single stress domains. We evaluated the association between a composite measure of perceived stress and CVD risk factors and outcomes. METHODS: Participants from the Dallas Heart Study phase 2 (2007-2009) without prevalent CVD who completed questionnaire assessments of perceived stress were included (n=2685). Individual perceived stress subcomponents (generalized stress, psychosocial, financial, and neighborhood stress) were standardized and integrated into a single cumulative stress score (CSS) with equal weighting for each component. Associations between CSS and demographics, psychosocial variables and cardiac risk factors were assessed in univariable and multivariable analyses. Cox proportional hazards models were used to determine associations of the CSS with atherosclerotic CVD (ASCVD) and Global CVD (ASCVD, heart failure, and atrial fibrillation) after adjustment for demographics and traditional risk factors. RESULTS: Median age of the study population was 48 years, 55% were female, 49% Black and 15% Hispanic/Latinx. CSS was higher among participants who were younger, female, Black or Hispanic, and those with lower income and educational attainment (p one year previously (p

Published
2023

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