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372 results on '"Pomarol-Clotet E"'

1. The role of BDNF and NGF plasma levels in first-episode schizophrenia: A longitudinal study

Author

Amoretti, S, Morén, C, Urbiola, E, González-Peñas, J, Roldán, A, Catalán, A, González-Ortega, I, Toll, A, Legido, T, Sanchez-Pastor, L, Dompablo, M, Pomarol-Clotet, E, R, Landín-Romero, Butjosa, A, Rubio, E, Lorente-OmeñacaR, Ribeiro, M, López-Torres, I, León-Quismondo, L, Nácher, J, Contretas, F, Lobo, A, Gutiérrez-Fraile, M, Sáiz, PA, Martínez-Pinteño, Albert, Mezquida, Gisela, Bioque, Miquel, López-Ilundain, Jose M, Andreu-Bernabeu, Álvaro, Zorrilla, Iñaki, Mané, Anna, Rodríguez-Jiménez, Roberto, Corripio, Iluminada, Sarró, Salvador, Ibáñez, Ángela, Usall, Judith, Rivero, Olga, Gassó, Patricia, Leza, Juan Carlos, Cuesta, Manuel J, Parellada, Mara, González-Pinto, Ana, Berrocoso, Esther, Mas, Sergi, and Bernardo, Miguel

Published
2022
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3. Detection of illicit phrasal movement in Huntington's disease.

Author

Tovar, A., Perry, S. J., Muñoz, E., Painous, C., Santacruz, P., Ruiz-Idiago, J., Mareca, C., Pomarol-Clotet, E., and Hinzen, W.

Subjects
SPEECH disorder diagnosis, COMPARATIVE grammar, CROSS-sectional method, RESEARCH funding, EXECUTIVE function, LOGISTIC regression analysis, BASAL ganglia, MOVEMENT disorders, DESCRIPTIVE statistics, NATURAL language processing, RESEARCH, NEUROPSYCHOLOGICAL tests, COGNITION disorders, SEMANTICS, JUDGMENT (Psychology), DATA analysis software, HUNTINGTON disease, DISEASE progression, DISEASE complications
Abstract

The role of the basal ganglia has been a longstanding issue in neural language models. Huntington's disease (HD) shows primary impairment in the striatum and has previously been shown to affect the processing of phrase-structural hierarchies that are built by phrasal movement (e.g. in passives). Here we asked patients with HD to judge the acceptability of sentences containing different types of illicit phrasal movement, which were contrasted with semantic violations involving no movement. A logistic mixed-effects regression showed that patients had a profound impairment in judging incorrect but not correct sentences across all types of illicit movement, while the semantic condition was also affected, but significantly less so. Adding neuropsychological variables to the model did not improve predictions. These results demonstrate a loss of cognitive control, worsening with disease progression, over phrase-structural hierarchies, which extends to forms of meaning built at sentential levels. [ABSTRACT FROM AUTHOR]

Published
2024
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19. The factor structure of the Opening Minds Stigma Scale for Healthcare Providers on psychiatrists from 32 European countries

Author

Ori, D., Szocsics, P., Molnár, T., Wallies, M., Kazakova, O., Bankovska-Motlova, L., Mörkl, S., Boivin, S., Raaj, S., Klinkby, I.M. Ingeholm, Cabacos, C., Pereira, A.T., Metheiken, S., Kakar, S., Greguras, S., Maslak, J., Nechepurenko, N., Kotsis, K., Kafali, H. Yilmaz, Mirkovic, A., Prelog, P. Rus, Bruna, K., Guevara, K., Strumilla, R., Abdulhakim, M., Carbone, E.A., Panayi, A., Ivanovic, I., Dashi, E., Grech, G., Vircik, M., Schuster, F., Soler-Vidal, J., Pomarol-Clotet, E., Ahmadova, G., Kisand, H., Hargi, A., Grinko, N., Rózsa, S., and Győrffy, Z.

Published
2022
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24. Epigenetic clocks in relapse after a first episode of schizophrenia

Author

Coll, L. Prohens, Gonzálex Segura, À., Mezquida, G., Amoretti, S., Bioque, M., Ribeiro, M., Gurriarán-Bas, X., Rementería, L., Berge, D., Rodriguez-Jimenez, R., Roldán, A., Pomarol-Clotet, E., Ibáñez, A., Usall, J., García-Portilla, M. Paz, Cuesta, M. Jesús, Parellada, M., González-Pinto, A., Berrocoso, E., Bernardo, M., and Mas, S.

Published
2022
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25. Concurrent antiepileptic and antipsychotic use moderates lithium’s effects on regional brain volumes: a mega-analysis from the ENIGMA-Bipolar Disorder Working Group

Author

King, S., Tronchin, G., Nabulsi, L., Thomopoulos, S.I., Fontana, E., Radua, J., Sim, K., Gruber, O., Yatham, L., Dannlowski, U., Kircher, T., Nenadic, I., Stein, F., Brosch, K., Howells, F., Haarman, B.C.M., Pomarol-Clotet, E., Vieta, E., Landen, M., Cannon, D., Alnæs, D., Westlye, L.T., Jaramillo, C. López, Soeiro-de-Souza, M. Gerhardt, Berk, M., Elvsåshagen, T., Roberts, G., Mitchell, P.B., Fullerton, J.M., Green, M.J., Quidé, Y., Hermesdorf, M., Berger, K., Soares, J., Satterthwaite, T., Savitz, J., Benedetti, F., Glahn, D., Hajek, T., Kuplicki, R., Gotlib, I.H., Amoretti, S., Sacchet, M., Favre, P., Van Rheenen, T., Karantonis, J. Anthony, Furlong, L., Forte, F., Rossell, S., Goldstein, B., Kennedy, K., Canales-Rodriguez, E., Lahud, E., Mwangi, B., Rodriguez-Cano, E., Salvador, R., Wu, M.-J., Houenou, J., Rodrigue, A., Melloni, E.M.T., Sponheim, S., Urosevic, S., Demro, C., Goya-Maldonado, R., Eyler, L., Thompson, P.M., Andreassan, O.A., Ching, C.R.K., and McDonald, C.

Published
2022
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35. Correction: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals (Neuropsychopharmacology, (2019), 44, 13, (2285-2293), 10.1038/s41386-019-0485-6)

Author

Favre P., Pauling M., Stout J., Hozer F., Sarrazin S., Abe C., Alda M., Alloza C., Alonso-Lana S., Andreassen O. A., Baune B. T., Benedetti F., Busatto G. F., Canales-Rodriguez E. J., Caseras X., Chaim-Avancini T. M., Ching C. R. K., Dannlowski U., Deppe M., Eyler L. T., Fatjo-Vilas M., Foley S. F., Grotegerd D., Hajek T., Haukvik U. K., Howells F. M., Jahanshad N., Kugel H., Lagerberg T. V., Lawrie S. M., Linke J. O., McIntosh A., Melloni E. M. T., Mitchell P. B., Polosan M., Pomarol-Clotet E., Repple J., Roberts G., Roos A., Rosa P. G. P., Salvador R., Sarro S., Schofield P. R., Serpa M. H., Sim K., Stein D. J., Sussmann J. E., Temmingh H. S., Thompson P. M., Verdolini N., Vieta E., Wessa M., Whalley H. C., Zanetti M. V., Leboyer M., Mangin J. -F., Henry C., Duchesnay E., Houenou J., Favre, P., Pauling, M., Stout, J., Hozer, F., Sarrazin, S., Abe, C., Alda, M., Alloza, C., Alonso-Lana, S., Andreassen, O. A., Baune, B. T., Benedetti, F., Busatto, G. F., Canales-Rodriguez, E. J., Caseras, X., Chaim-Avancini, T. M., Ching, C. R. K., Dannlowski, U., Deppe, M., Eyler, L. T., Fatjo-Vilas, M., Foley, S. F., Grotegerd, D., Hajek, T., Haukvik, U. K., Howells, F. M., Jahanshad, N., Kugel, H., Lagerberg, T. V., Lawrie, S. M., Linke, J. O., Mcintosh, A., Melloni, E. M. T., Mitchell, P. B., Polosan, M., Pomarol-Clotet, E., Repple, J., Roberts, G., Roos, A., Rosa, P. G. P., Salvador, R., Sarro, S., Schofield, P. R., Serpa, M. H., Sim, K., Stein, D. J., Sussmann, J. E., Temmingh, H. S., Thompson, P. M., Verdolini, N., Vieta, E., Wessa, M., Whalley, H. C., Zanetti, M. V., Leboyer, M., Mangin, J. -F., Henry, C., Duchesnay, E., and Houenou, J.

Abstract

This Article was originally published under NPG's License to Publish, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the Article have been modified accordingly.

Published
2019

37. Brain correlates of recall of negative autobiographical memories in patients with schizophrenia.

Author

Barbosa, L., Aquino-Servín, A., Fuentes-Claramonte, P., García-León, M. Á., Karuk, A., Jaurrieta, N., Hoyas-Galán, B., Ramiro-Sousa, N., Corte-Souto, C., McKenna, P., and Pomarol-Clotet, E.

Subjects
DEFAULT mode network, AUDITORY hallucinations, FRONTAL lobe, FUNCTIONAL magnetic resonance imaging, SCHIZOAFFECTIVE disorders, AUTOBIOGRAPHICAL memory
Abstract

Introduction: Autobiographical memory is known to be disturbed in schizophrenia. In addition, a leading theory of auditory hallucinations (AVH) is that they are intrusive – typically negative – autobiographical memories that are misinterpreted as perceptions. Objectives: The aim of this study was to examine the brain functional correlates of recall of negatively emotionally valanced autobiographical memories in patients with schizophrenia, with a longer term aim of comparing patients with and without AVH. Methods: 11 patients meeting DSM-5 criteria for schizophrenia or schizoaffective disorder and 10 age, sex and estimated premorbid IQ-matched healthy controls have so far taken part. Participants underwent functional MRI in a 3T scanner while performing a task requiring them to recall autobiographical memories in response to individually tailored pairs of cue words. The cue words were based on autobiographical memories previously elicited in an interview with each patient and were designed to evoke the same memory. The cue words were presented in 10 20-second blocks interspersed with blocks where the subjects viewed cue words that did not evoke autobiographical memories. Brain activations were examined in three contrasts of interest: memory evoking words vs baseline, neutral words vs baseline and memory evoking vs neutral words. Pre-processing and analysis were carried out with the FEAT module included in the FSL software. Statistical analysis was performed by means of a General Linear Model (GLM) approach. Results: In the memory evoking vs baseline contrast the patients showed hypoactivation in the medial frontal cortex compared to the healthy controls (Figure 1). There were no differences in activation between the patients and the controls comparing the memory evoking and neutral cues. Image: Conclusions: The finding of hypoactivation in the medial frontal cortex compared to low level baseline in patients with schizophrenia suggests dysfunction in the default mode network, which is known to activate during recall of autobiographical memories. These preliminary results suggest that recall of negative autobiographical memories in patients with schizophrenia is associated with reduced activity in the default mode network. A planned larger sample of patients and controls will be used to examine activations in patients with and without AVH. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Published
2024
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39. Association and epistatic analysis of white matter related genes across the continuum schizophrenia and autism spectrum disorders: The joint effect of NRG1-ErbB genes.

Author

Prats, C., Fatjó-Vilas, M., Penzol, M. J., Kebir, O., Pina-Camacho, L., Demontis, D., Crespo-Facorro, B., Peralta, V., González-Pinto, A., Pomarol-Clotet, E., Papiol, S., Parellada, M., Krebs, M. O., and Fañanás, L.

Subjects
AUTISM spectrum disorders, SCHIZOPHRENIA, WHITE matter (Nerve tissue), JOINT diseases, GENES, CHILDREN with autism spectrum disorders, MYELIN proteins
Abstract

Schizophrenia-spectrum disorders (SSD) and Autism spectrum disorders (ASD) are neurodevelopmental disorders that share clinical, cognitive, and genetic characteristics, as well as particular white matter (WM) abnormalities. In this study, we aimed to investigate the role of a set of oligodendrocyte/myelin-related (OMR) genes and their epistatic effect on the risk for SSD and ASD. We examined 108 SNPs in a set of 22 OMR genes in 1749 subjects divided into three independent samples (187 SSD trios, 915 SSD cases/control, and 91 ASD trios). Genetic association and gene-gene interaction analyses were conducted with PLINK and MB-MDR, and permutation procedures were implemented in both. Some OMR genes showed an association trend with SSD, while after correction, the ones that remained significantly associated were MBP, ERBB3, and AKT1. Significant gene-gene interactions were found between (i) NRG1*MBP (perm p-value = 0.002) in the SSD trios sample, (ii) ERBB3*AKT1 (perm p-value = 0.001) in the SSD case-control sample, and (iii) ERBB3*QKI (perm p-value = 0.0006) in the ASD trios sample. Our results suggest the implication of OMR genes in the risk for both SSD and ASD and highlight the role of NRG1 and ERBB genes. These findings are in line with the previous evidence and may suggest pathophysiological mechanisms related to NRG1/ERBBs signalling in these disorders. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Brain functional correlates of formal thought disorder in schizophrenia: examining the frontal/dysexecutive hypothesis.

Author

Fuentes-Claramonte, P., López-Araquistain, L., Sarró, S., Sans-Sansa, B., Ortiz-Gil, J., Maristany, T., Salvador, R., McKenna, P.J., and Pomarol-Clotet, E.

Subjects
BRAIN physiology, THALAMUS physiology, EXECUTIVE function, SPEECH disorders, SCHIZOPHRENIA, BASAL ganglia, TASK performance, CASE-control method, MAGNETIC resonance imaging, SHORT-term memory
Abstract

Background: One hypothesis proposed to underlie formal thought disorder (FTD), the incoherent speech is seen in some patients with schizophrenia, is that it reflects impairment in frontal/executive function. While this proposal has received support in neuropsychological studies, it has been relatively little tested using functional imaging. This study aimed to examine brain activations associated with FTD, and its two main factor-analytically derived subsyndromes, during the performance of a working memory task. Methods: Seventy patients with schizophrenia showing a full range of FTD scores and 70 matched healthy controls underwent fMRI during the performance of the 2-back version of the n-back task. Whole-brain corrected, voxel-based correlations with FTD scores were examined in the patient group. Results: During 2-back performance the patients showed clusters of significant inverse correlation with FTD scores in the inferior frontal cortex and dorsolateral prefrontal cortex bilaterally, the left temporal cortex and subcortically in the basal ganglia and thalamus. Further analysis revealed that these correlations reflected an association only with 'alogia' (poverty of speech, poverty of content of speech and perseveration) and not with the 'fluent disorganization' component of FTD. Conclusions: This study provides functional imaging support for the view that FTD in schizophrenia may involve impaired executive/frontal function. However, the relationship appears to be exclusively with alogia and not with the variables contributing to fluent disorganization. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group

Author

Hibar, DP, Westlye, LT, Doan, NT, Jahanshad, N, Cheung, JW, Ching, CRK, Versace, A, Bilderbeck, AC, Uhlmann, A, Mwangi, B, Krämer, B, Overs, B, Hartberg, CB, Abe, C, Dima, D, Grotegerd, D, Sprooten, E, Ben, E, Jimenez, E, Howells, FM, Delvecchio, G, Temmingh, H, Starke, J, Almeida, JRC, Goikolea, JM, Houenou, J, Beard, LM, Rauer, L, Abramovic, L, Bonnin, M, Ponteduro, MF, Keil, M, Rive, MM, Yao, N, Yalin, N, Najt, P, Rosa, PG, Redlich, R, Trost, S, Hagenaars, S, Fears, SC, Alonso-Lana, S, Van Erp, TGM, Nickson, T, Chaim-Avancini, TM, Meier, TB, Elvsashagen, T, Haukvik, UK, Lee, WH, Schene, AH, Lloyd, AJ, Young, AH, Nugent, A, Dale, AM, Pfennig, A, McIntosh, AM, Lafer, B, Baune, BT, Ekman, CJ, Zarate, CA, Bearden, CE, Henry, C, Simhandl, C, McDonald, C, Bourne, C, Stein, DJ, Wolf, DH, Cannon, DM, Glahn, DC, Veltman, DJ, Pomarol-Clotet, E, Vieta, E, Canales-Rodriguez, EJ, and Nery, FG

Abstract

© 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions. In BD, cortical gray matter was thinner in frontal, temporal and parietal regions of both brain hemispheres. BD had the strongest effects on left pars opercularis (Cohen's d='0.293; P=1.71 × 10 '21), left fusiform gyrus (d='0.288; P=8.25 × 10 '21) and left rostral middle frontal cortex (d='0.276; P=2.99 × 10 '19). Longer duration of illness (after accounting for age at the time of scanning) was associated with reduced cortical thickness in frontal, medial parietal and occipital regions. We found that several commonly prescribed medications, including lithium, antiepileptic and antipsychotic treatment showed significant associations with cortical thickness and surface area, even after accounting for patients who received multiple medications. We found evidence of reduced cortical surface area associated with a history of psychosis but no associations with mood state at the time of scanning. Our analysis revealed previously undetected associations and provides an extensive analysis of potential confounding variables in neuroimaging studies of BD.

Published
2018

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