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23 results on '"Piro, Francesco"'

1. L’ammirazione in Cartesio e Spinoza. Classificazione degli affetti e costituzione dello spazio antropologico

Author

Piro, Francesco

Subjects
Descartes, Spinoza, emotions, reason, philosophical anthropology, History of scholarship and learning. The humanities, AZ20-999, Philosophy (General), B1-5802
Abstract

The status of «Admiration» in Descartes and Spinoza is illustrated by F. Piro as an index of different anthropological options, concerning the relationships between emotions and rationality and the role that they play in social, political and religious behavior. The differences in metaphysical assumptions that separate the two thinkers as well as the internal evolution of their thinking are enucleated under such perspective. In the background there are at least three main philosophical issues: (i) the classic issue of the «primary» emotions (also in the current form of a question about the «anthropological universals»); (ii) the issue of the existence and nature of moral sentiments and, at the end, (iii) that of the status of the «admirable» or «amazing» in the age of the scientific revolution.

Published
2009

2. Time performance of Analog Pixel Test Structures with in-chip operational amplifier implemented in 65 nm CMOS imaging process

Author

Rinella, Gianluca Aglieri, Aglietta, Luca, Antonelli, Matias, Barile, Francesco, Benotto, Franco, Beolè, Stefania Maria, Botta, Elena, Bruno, Giuseppe Eugenio, Carnesecchi, Francesca, Colella, Domenico, Colelli, Angelo, Contin, Giacomo, Robertis, Giuseppe De, Dumitrache, Floarea, Elia, Domenico, Ferrero, Chiara, Fransen, Martin, Kluge, Alex, Kumar, Shyam, Lemoine, Corentin, Licciulli, Francesco, Lim, Bong-Hwi, Loddo, Flavio, Mager, Magnus, Marras, Davide, Martinengo, Paolo, Pastore, Cosimo, Patra, Rajendra Nath, Perciballi, Stefania, Piro, Francesco, Prino, Francesco, Ramello, Luciano, Ramos, Arianna Grisel Torres, Reidt, Felix, Russo, Roberto, Sarritzu, Valerio, Savino, Umberto, Schledewitz, David, Selina, Mariia, Senyukov, Serhiy, Sitta, Mario, Snoeys, Walter, Sonneveld, Jory, Suljic, Miljenko, Triloki, Triloki, and Turcato, Andrea

Published
2025
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3. Characterization of analogue Monolithic Active Pixel Sensor test structures implemented in a 65 nm CMOS imaging process

Author

Aglieri Rinella, Gianluca, Alocco, Giacomo, Antonelli, Matias, Baccomi, Roberto, Beole, Stefania Maria, Blidaru, Mihail Bogdan, Buttwill, Bent Benedikt, Buschmann, Eric, Camerini, Paolo, Carnesecchi, Francesca, Chartier, Marielle, Choi, Yongjun, Colocci, Manuel, Contin, Giacomo, Dannheim, Dominik, De Gruttola, Daniele, Del Rio Viera, Manuel, Dubla, Andrea, di Mauro, Antonello, Donner, Maurice Calvin, Eberwein, Gregor Hieronymus, Egger, Jan, Fabbietti, Laura, Feindt, Finn, Gautam, Kunal, Gernhaeuser, Roman, Glover, James Julian, Gonella, Laura, Gran Grodaas, Karl, Gregor, Ingrid-Maria, Hillemanns, Hartmut, Huth, Lennart, Ilg, Armin, Isakov, Artem, Jones, Daniel Matthew, Junique, Antoine, Kaewjai, Jetnipit, Keil, Markus, Kim, Jiyoung, Kluge, Alex, Kobdaj, Chinorat, Kotliarov, Artem, Kittimanapun, Kritsada, Křížek, Filip, Kucharska, Gabriela, Kushpil, Svetlana, La Rocca, Paola, Laojamnongwong, Natthawut, Lautner, Lukas, Lemmon, Roy Crawford, Lemoine, Corentin, Li, Long, Librizzi, Francesco, Liu, Jian, Macchiolo, Anna, Mager, Magnus, Marras, Davide, Martinengo, Paolo, Masciocchi, Silvia, Mattiazzo, Serena, Menzel, Marius Wilm, Mulliri, Alice, Musta, Alexander, Mylne, Mia Rose, Piro, Francesco, Rachevski, Alexandre, Rasà, Marika, Rebane, Karoliina, Reidt, Felix, Ricci, Riccardo, Ruiz Daza, Sara, Saccà, Gaspare, Sanna, Isabella, Sarritzu, Valerio, Schlaadt, Judith, Schledewitz, David, Scioli, Gilda, Senyukov, Serhiy, Simancas, Adriana, Snoeys, Walter, Spannagel, Simon, Šuljić, Miljenko, Sturniolo, Alessandro, Tiltmann, Nicolas, Trifirò, Antonio, Usai, Gianluca, Vanat, Tomas, Van Beelen, Jacob Bastiaan, Varga, Laszlo, Verdoglia, Michele, Vignola, Gianpiero, Villani, Anna, Wennloef, Haakan, Witte, Jonathan, and Wittwer, Rebekka Bettina

Published
2024
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4. Radiation hardness of MALTA2 monolithic CMOS imaging sensors on Czochralski substrates

Author

van Rijnbach, Milou, Berlea, Dumitru Vlad, Dao, Valerio, Gaži, Martin, Allport, Phil, Tortajada, Ignacio Asensi, Behera, Prafulla, Bortoletto, Daniela, Buttar, Craig, Dachs, Florian, Dash, Ganapati, Dobrijević, Dominik, Fasselt, Lucian, de Acedo, Leyre Flores Sanz, Gabrielli, Andrea, Gonella, Laura, González, Vicente, Gustavino, Giuliano, Jana, Pranati, Li, Long, Pernegger, Heinz, Piro, Francesco, Riedler, Petra, Sandaker, Heidi, Sánchez, Carlos Solans, Snoeys, Walter, Suligoj, Tomislav, Núñez, Marcos Vázquez, Vijay, Anusree, Weick, Julian, Worm, Steven, and Zoubir, Abdelhak M.

Published
2024
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5. Digital pixel test structures implemented in a 65 nm CMOS process

Author

Aglieri Rinella, Gianluca, Andronic, Anton, Antonelli, Matias, Aresti, Mauro, Baccomi, Roberto, Becht, Pascal, Beole, Stefania, Braach, Justus, Buckland, Matthew Daniel, Buschmann, Eric, Camerini, Paolo, Carnesecchi, Francesca, Cecconi, Leonardo, Charbon, Edoardo, Contin, Giacomo, Dannheim, Dominik, de Melo, Joao, Deng, Wenjing, di Mauro, Antonello, Hasenbichler, Jan, Hillemanns, Hartmut, Hong, Geun Hee, Isakov, Artem, Junique, Antoine, Kluge, Alex, Kotliarov, Artem, Křížek, Filip, Lautner, Lukas, Mager, Magnus, Marras, Davide, Martinengo, Paolo, Masciocchi, Silvia, Menzel, Marius Wilm, Munker, Magdalena, Piro, Francesco, Rachevski, Alexandre, Rebane, Karoliina, Reidt, Felix, Russo, Roberto, Sanna, Isabella, Sarritzu, Valerio, Senyukov, Serhiy, Snoeys, Walter, Sonneveld, Jory, Šuljić, Miljenko, Svihra, Peter, Tiltmann, Nicolas, Usai, Gianluca, Van Beelen, Jacob Bastiaan, Vassilev, Mirella Dimitrova, Vernieri, Caterina, and Villani, Anna

Published
2023
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6. Performance of the MALTA telescope

Author

van Rijnbach, Milou, Gustavino, Giuliano, Allport, Phil, Tortajada, Ignacio Asensi, Berlea, Dumitru Vlad, Bortoletto, Daniela, Buttar, Craig, Charbon, Edoardo, Dachs, Florian, Dao, Valerio, Dobrijevic, Dominik, de Acedo, Leyre Flores Sanz, Gabrielli, Andrea, Gazi, Martin, Gonella, Laura, Gonzalez, Vicente, Guidon, Stefan, LeBlanc, Matt, Pernegger, Heinz, Piro, Francesco, Riedler, Petra, Sandaker, Heidi, Sharma, Abhishek, Sanchez, Carlos Solans, Snoeys, Walter, Suligoj, Tomislav, Nunez, Marcos Vazquez, Weick, Julian, Worm, Steven, and Zoubir, Abdelhak M.

Published
2023
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7. Recent results with radiation-tolerant TowerJazz 180 nm MALTA sensors

Author

LeBlanc, Matt, Allport, Phil, Asensi, Igancio, Berlea, Dumitru-Vlad, Bortoletto, Daniela, Buttar, Craig, Dachs, Florian, Dao, Valerio, Denizli, Haluk, Dobrijevic, Dominik, Flores, Leyre, Gabrielli, Andrea, Gonella, Laura, González, Vicente, Gustavino, Giuliano, Oyulmaz, Kaan, Pernegger, Heinz, Piro, Francesco, Riedler, Petra, Sandaker, Heidi, Solans, Carlos, Snoeys, Walter, Suligoj, Tomislav, van Rijnbach, Milou, Sharma, Abhishek, Núñez, Marcos Vázquez, Weick, Julian, Worm, Steven, and Zoubir, Abdelhak

Published
2022
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8. MALTA3: Concepts for a new radiation tolerant sensor in the TowerJazz 180 nm technology

Author

Dobrijević, Dominik, Allport, Phil, Asensi, Ignacio, Berlea, Dumitru-Vlad, Bortoletto, Daniela, Buttar, Craig, Dachs, Florian, Dao, Valerio, Denizli, Haluk, Flores, Leyre, Gabrielli, Andrea, Gonella, Laura, González, Vicente, LeBlanc, Matt, Vázquez Núñez, Marcos, Oyulmaz, Kaan, Pernegger, Heinz, Piro, Francesco, Riedler, Petra, Sandaker, Heidi, Sánchez, Carlos Solans, Snoeys, Walter, Suligoj, Tomislav, van Rijnbach, Milou, Weick, Julian, and Worm, Steven

Published
2022
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9. Charge sensing properties of monolithic CMOS pixel sensors fabricated in a 65 nm technology

Author

Bugiel, Szymon, Dorokhov, Andrei, Aresti, Mauro, Baudot, Jerome, Beole, Stefania, Besson, Auguste, Bugiel, Roma, Cecconi, Leonardo, Colledani, Claude, Deng, Wenjing, Di Mauro, Antonello, Bitar, Ziad El, Goffe, Mathieu, Hasenbichler, Jan, Hong, Geun Hee, Hu-Guo, Christine, Jaaskelainen, Kimmo, Kluge, Alex, Mager, Magnus, Marras, Davide, de Melo, Joao, Munker, Magdalena, Pham, Hung, Piro, Francesco, Reidt, Felix, Rinella, Gianluca Aglieri, Russo, Roberto, Sarritzu, Valerio, Senyukov, Serhiy, Snoeys, Walter, Suljic, Miljenko, Usai, Gianluca, Valin, Isabelle, Winter, Marc, and Wu, Yitao

Published
2022
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13. L’argomento del 'miracolo perpetuo' e i suoi sottintesi teologici. Ancora sui rapporti Leibniz-Malebranche

Author

Piro, Francesco

Subjects
Philosophical Theology, Miracle, Economy of Grace, Occasionalism, Natural Philosophy, lcsh:Philosophy (General), lcsh:AZ20-999, lcsh:B1-5802, lcsh:History of scholarship and learning. The humanities
Abstract

The Argument of the “Perpetual Miracle” and its Theological Implications: on Leibniz-Malebranche Relationships. One of Leibniz’s strongest arguments against the Occasionalists (including Malebranche) is that, since they see all natural laws only as constant connections, Occasionalists are unable to distinguish a natural law from a constantly repeated miracle (argument of the “perpetual miracle”). The paper shows that Leibniz’s argument is not entirely adequate as a criticism of Malebranche, in that it stems from a theology that is quite different to that of Malebranche. For Malebranche, miracles are the effects of God’s “particular will” and are quite different even from God’s legal distribution of Grace. A miracle ruled by a law is, therefore, a conceptual impossibility. To Leibniz, miracles include everything that overrules creatures and their forces. Miracles may thus be governed by laws and, indeed, all miracles performed by God in our world are regulated by the laws of Leibniz’s Kingdom of Grace.

Published
2017

16. Creaturely Action in Leibniz's Theodicy

Author

Piro, Francesco

Subjects
Occasionalism, Philosophy of Action, Continuous Creation, Continuous Creation, Occasionalism, Philosophy of Action
Published
2016

17. Rab7 and the CMT2B disease

Author

Laura Cogli, PIRO, FRANCESCO, BUCCI, Cecilia, Cogli, Laura, Piro, Francesco, and Bucci, Cecilia

Abstract

The CMT2B (Charcot-Marie-Tooth type 2B) disease is an autosomal dominant axonal neuropathy. Sensory loss, distal muscle weakness and wasting, frequent foot ulcers and amputations of the toes due to frequent infections characterize this neuropathy. Four missense mutations in the rab7 gene have been identified as causative of the disease. Rab7 is a small G-protein of the Rab family that controls vesicular transport to late endosomes and lysosomes in the endocytic pathway. The CMT2B-associated mutant Rab7 proteins show altered nucleotide dissociation rates and impaired GTPase activity. In addition, these mutant proteins are predominantly in the GTP-bound form when expressed in human cells and they are able to rescue Rab7 function in Rab7-depleted cells. Thus these mutations generate activated forms of Rab7 that are responsible for the development of the disease. In spite of these results, there are still important gaps in our understanding of the mechanism underlying CMT2B. Indeed, how these mutations in the rab7 gene affect specifically peripheral neurons leading to an axonal pathology in CMT2B is not clear, and it is a particularly puzzling and challenging issue in view of the fact that Rab7 is a ubiquitous protein. The present review discusses possible molecular mechanisms underlying CMT2B.

Published
2009

21. Rab7b controls trafficking from endosomes to the TGN.

Author

Progida, Cinzia, Cogli, Laura, Piro, Francesco, de Luca, Azzurra, Bakke, Oddmund, and Bucci, Cecilia

Subjects
ENDOSOMES, LYSOSOMES, ENZYMES, GOLGI apparatus, TAY-Sachs disease, VESICULAR stomatitis, G proteins
Abstract

Rab7b is a recently identified member of the Rab GTPase protein family and has high similarity to Rab7. It has been reported that Rab7b is lysosome associated, that it is involved in monocytic differentiation and that it promotes lysosomal degradation of TLR4 and TLR9. Here we investigated further the localization and function of this GTPase. We found that wild-type Rab7b is lysosome associated whereas an activated, GTP-bound form of Rab7b localizes to the Golgi apparatus. In contrast to Rab7, Rab7b is not involved in EGF and EGFR degradation. Depletion of Rab7b or expression of Rab7b T22N, a Rab7b dominant-negative mutant, impairs cathepsin-D maturation and causes increased secretion of hexosaminidase. Moreover, expression of Rab7b T22N or depletion of Rab7b alters TGN46 distribution, cation-independent mannose-6-phosphate receptor (CI-MPR) trafficking, and causes an increase in the levels of the late endosomal markers CI-MPR and cathepsin D. Vesicular stomatitis virus G protein (VSV-G) trafficking, by contrast, is normal in Rab7b-depleted or Rab7b-T22N-expressing cells. In addition, depletion of Rab7b prevents cholera toxin B-subunit from reaching the Golgi. Altogether, these data indicate that Rab7b is required for normal lysosome function, and, in particular, that it is an essential factor for retrograde transport from endosomes to the trans-Golgi network (TGN). [ABSTRACT FROM AUTHOR]

Published
2010
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22. Update on pre-diabetes: Focus on diagnostic criteria and cardiovascular risk.

Author

Di Pino A, Urbano F, Piro S, Purrello F, and Rabuazzo AM

Abstract

Pre-diabetes, which is typically defined as blood glucose concentrations higher than normal but lower than the diabetes threshold, is a high-risk state for diabetes and cardiovascular disease development. As such, it represents three groups of individuals: Those with impaired fasting glucose (IFG), those with impaired glucose tolerance (IGT) and those with a glycated haemoglobin (HbA 1c ) between 39-46 mmol/mol. Several clinical trials have shown the important role of IFG, IGT and HbA 1c -pre-diabetes as predictive tools for the risk of developing type 2 diabetes. Moreover, with regard to cardiovascular disease, pre-diabetes is associated with more advanced vascular damage compared with normoglycaemia, independently of confounding factors. In view of these observations, diagnosis of pre-diabetes is mandatory to prevent or delay the development of the disease and its complications; however, a number of previous studies reported that the concordance between pre-diabetes diagnoses made by IFG, IGT or HbA 1c is scarce and there are conflicting data as to which of these methods best predicts cardiovascular disease. This review highlights recent studies and current controversies in the field. In consideration of the expected increased use of HbA 1c as a screening tool to identify individuals with alteration of glycaemic homeostasis, we focused on the evidence regarding the ability of HbA 1c as a diagnostic tool for pre-diabetes and as a useful marker in identifying patients who have an increased risk for cardiovascular disease. Finally, we reviewed the current evidence regarding non-traditional glycaemic biomarkers and their use as alternatives to or additions to traditional ones., Competing Interests: Conflict-of-interest statement: The authors declare no conflict of interest for this article.

Published
2016
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23. Rab7 and the CMT2B disease.

Author

Cogli L, Piro F, and Bucci C

Subjects
Charcot-Marie-Tooth Disease pathology, Charcot-Marie-Tooth Disease physiopathology, Humans, Intracellular Membranes metabolism, Models, Molecular, Neurons metabolism, Neurons ultrastructure, Protein Structure, Tertiary, rab GTP-Binding Proteins chemistry, rab GTP-Binding Proteins genetics, rab7 GTP-Binding Proteins, Charcot-Marie-Tooth Disease genetics, Charcot-Marie-Tooth Disease metabolism, rab GTP-Binding Proteins metabolism
Abstract

The CMT2B (Charcot-Marie-Tooth type 2B) disease is an autosomal dominant axonal neuropathy. Sensory loss, distal muscle weakness and wasting, frequent foot ulcers and amputations of the toes due to frequent infections characterize this neuropathy. Four missense mutations in the rab7 gene have been identified as causative of the disease. Rab7 is a small G-protein of the Rab family that controls vesicular transport to late endosomes and lysosomes in the endocytic pathway. The CMT2B-associated mutant Rab7 proteins show altered nucleotide dissociation rates and impaired GTPase activity. In addition, these mutant proteins are predominantly in the GTP-bound form when expressed in human cells and they are able to rescue Rab7 function in Rab7-depleted cells. Thus these mutations generate activated forms of Rab7 that are responsible for the development of the disease. In spite of these results, there are still important gaps in our understanding of the mechanism underlying CMT2B. Indeed, how these mutations in the rab7 gene affect specifically peripheral neurons leading to an axonal pathology in CMT2B is not clear, and it is a particularly puzzling and challenging issue in view of the fact that Rab7 is a ubiquitous protein. The present review discusses possible molecular mechanisms underlying CMT2B.

Published
2009
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