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Background: Shad Karanas mentioned in Ayurveda are the means for attaining the state of Dhatusamyata. Samavaya is the sixth Karana among these and it provides the knowledge of relation between Dravya, Guna and Karma. This kind of knowledge becomes the basic tool in the field of diagnosis as well as in the selection of proper drug. Aim: To assess the Samavaya relation between Ama and its Hetu and Lakshanas along with Practical evaluation of Samavaya by using Pippalimula on Ama. Materials and Methods: The study comprising of total 23 patients of Ama and divided into two groups. Pippalimula tablet (each of 500 mg, 2 tablets four times daily) was administered in Group A (n = 13) while Group B (n = 10) was treated with placebo tablet (each of 500 mg, 2 tablets four times daily) for the duration of 10 days. Results: After the completion of treatment, all the parameters of Group A showed statistically highly signifi cant results, whereas in Group B some parameters showed significant results and others were insignificant. Conclusion: The study specified the Karanatva of Samavaya as the Laghu, Ruksha and Ushna Gunas which were present Samavayatvena in Pippalimula, and were absent in placebo. [ABSTRACT FROM AUTHOR]

Several species of Piper are used in indigenous system of medicine in India. The root (Pippalimula) and fruit(Pippali) of Piper longum Linn. is possessing high therapeutic virtues. According to Ayurved system of medicine, the Piper longum Linn. roots are pungent and having heating, stomachic, laxative, anthelmintic and carminative properties. It improves the appetite and useful in bronchitis, abdominal pain, disease of the spleen and tumors. According to Unani system, root has a bitter, hot and sharp taste and used as carminative, hepato-protactive, stomachic, abortificient, haematinic, diuretic, digestive and as a general tonic. It also cures inflammation of the liver, pains in the joint, lumbago, snakebite, scorpion-sting and night-blindness. Plant Pippali is cultivated and also imported from other countries as it is highly demanded in pharmaceutical industries. It is reported as endangered species in some states. The cultivation practice of Piper longum Linn. is necessary to overcome its requirement in Pharmaceutics as its highly used plant for classical formulations. On experimental level, Pippalimula is reported having analgesic, antifungal, antimicrobial and anti-oxidant activities. Also, the fruit and root extract of Piper longum along with ciprofloxacin showed good synergistic activity against MRSA. P.longum roots along with E. ribes seeds pregnancy showed antifertility activity in female albino rats. Further scientific validations and clinical trials may sustain the classical claims regarding the root of Piper longum Linn. [ABSTRACT FROM AUTHOR]