Search

Your search keyword '"Pingqing Gu"' showing total 5 results
Start Over Author "Pingqing Gu" Language english
5 results on '"Pingqing Gu"'

1. Effect of Pregnancy on the Levels of Blood Cadmium and Lead: analysis of 2006-2011 Nanjing Maternity and Child Health Care Hospital Survey Data

Author

Kangsheng Liu, Pingqing Gu, Wenjun Chen, Juan Shi, Chuan Shi, and Li Xia

Subjects
Cadmium, Lead, Pregnancy, Iron, Smoking, China, Public aspects of medicine, RA1-1270
Abstract

Background: Prenatal lead exposure could not only affect various organ systems of the mother, but also provide a plumbeous environment for the fetus and newborns, and may affect the fetus in a number of detrimental ways. The aim of this study was to adequately determine the interaction between these factors and risky behaviors such as smoking.Methods: Data from Nanjing Maternity and Child Health Care Hospital survey during the years of 2006–2011 were used (n = 4400) to evaluate the effections of age, parity, body mass index (BMI), race/ethnicity, pregnancy, iron (Fe) storage status and smoking status on the consumption of the levels of blood cadmium (Cd) and lead (Pb) of females aged 16–35yr old. The blood samples were sent to determine blood lead / cadmium concentration by the Inductively Coupled Plasma Mass Spectrometry (ICP-MS) . STATA 12.1 software (www. stata.com) was used to fit regression models for each of the two metals.Results: For both of the two metals, age was positively while BMI was negatively associated with the levels of these metals in blood. Smokers showed statistically significantly higher levels of Cd and Pb ( P=0.007) , while irrespective of race/ethnicity and Fe storage status as compared to nonsmokers.Conclusion: Novel to this study, pregnancy was found to be associated with significantly lower levels of Cd and Pb, while irrespective of race/ethnicity and Fe storage status as compared to non-pregnant females. It is conceivable that pregnancy could thus accelerate clearance of these metals in the blood.

Published
2013

3. MicroRNA-29a induces insulin resistance by targeting PPARδ in skeletal muscle cells

Author

Xiaomei Cao, Qun Hao, Pingqing Gu, Qin Lu, Jingyun Li, Yuehua Zhou, Yu Zeng, and Weijie Shi

Subjects
0301 basic medicine, medicine.medical_specialty, Glucose uptake, Cell Line, Myoblasts, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, 0302 clinical medicine, Insulin resistance, Downregulation and upregulation, Pregnancy, Internal medicine, insulin resistance, Genetics, medicine, Myocyte, Animals, PPAR delta, C2C12 cells, Muscle, Skeletal, Fetal Growth Retardation, Glucose Transporter Type 4, biology, miR-29a, Glucose transporter, Skeletal muscle, General Medicine, Articles, intrauterine growth retardation, medicine.disease, Rats, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Glucose, Gene Expression Regulation, 030220 oncology & carcinogenesis, biology.protein, Peroxisome proliferator-activated receptor delta, Female, peroxisome proliferator activated receptor-δ, GLUT4
Abstract

Intrauterine growth retardation (IUGR) induces metabolic syndrome, which is often characterized by insulin resistance (IR), in adults. Previous research has shown that microRNAs (miRNAs or miRs) play a role in the target genes involved in this process, but the mechanisms remain unclear. In the present study, we examined miRNA profiles using samples of skeletal muscles from both IUGR and control rat offspring whose mothers were fed either a protein-restricted diet or a diet which involved normal amounts of protein during pregnancy, respectively. miR-29a was found to be upregulated in the skeletal muscles of IUGR offspring. The luciferase reporter assay confirmed the direct interaction between miR-29a and peroxisome proliferator-activated receptor δ (PPARδ). Overexpression of miR-29a in the skeletal muscle cell line C2C12 suppressed the expression of its target gene PPARδ, which, in turn, influenced the expression of its coactivator, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). Thus, PPARδ/PGC-1α-dependent signals together reduced insulin-dependent glucose uptake and adenosine triphosphate (ATP) production. Overexpression of miR-29a also caused a decrease in levels of glucose transporter 4 (GLUT4), the most important glucose transporter in skeletal muscle, which partially induced a decrease insulin-dependent glucose uptake. These findings provide evidence for a novel micro-RNA-mediated mechanism of PPARδ regulation, and we also noted the IR-promoting actions of miR-29a in skeletal muscles of IUGR.

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results