17 results on '"Picone T"'
Search Results
2. Growth, serum biochemistries, and amino acids of term infants fed formulas with amino acid and protein concentrations similar to human milk.
- Author
-
Picone, Thomas A., Benson, John D., Moro, Guido, Minoli, Iolanda, Fulconis, Fabio, Rassin, David K., Raiha, Niels C. R., Picone, T A, Benson, J D, Moro, G, Minoli, I, Fulconis, F, Rassin, D K, and Raiha, N C
- Published
- 1989
3. Fortification of human milk: evaluation of a novel fortification scheme and of a new fortifier.
- Author
-
Moro, G E, Minoli, I, Ostrom, M, Jacobs, J R, Picone, T A, Räihä, N C, and Ziegler, E E
- Published
- 1995
4. Cord blood amino acid concentrations from neonates of 23-41 weeks gestational age.
- Author
-
Pittard, William B., Geddes, Kitty M., Picone, Thomas A., Pittard, W B 3rd, Geddes, K M, and Picone, T A
- Published
- 1988
- Full Text
- View/download PDF
5. Cord blood tryptophan concentrations and total cysteine concentrations.
- Author
-
Picone, Thomas A., Daniels, Terri A., Ponto, Kim H., Pittard, William B., Picone, T A, Daniels, T A, Ponto, K H, and Pittard, W B 3rd
- Published
- 1989
- Full Text
- View/download PDF
6. Pregnancy outcome in North American women. II. Effects of diet, cigarette smoking, stress, and weight gain on placentas, and on neonatal physical and behavioral characteristics
- Author
-
Ferris, M. E., Picone, T. A., Olsen, P. N., and Allen, L. H.
- Subjects
DIET ,SMOKING ,PSYCHOLOGICAL stress - Published
- 1982
7. Pregnancy outcome in North American women. I. Effects of diet, cigarette smoking, and psychological stress on maternal weight gain
- Author
-
Allen, L. H., Olsen, P. N., Picone, T. A., and Schramm, M. M.
- Subjects
DIET ,WEIGHT gain in pregnancy ,SMOKING ,PSYCHOLOGICAL stress - Published
- 1982
8. Cost-effectiveness analysis of recruitment strategies in a large diabetes prevention trial conducted across two sites in Sydney, Australia.
- Author
-
Bessell E, Markovic TP, Caterson ID, Hendy C, Burk J, Picone T, and Fuller NR
- Subjects
- Adult, Humans, Patient Selection, Research Design, Australia, Cost-Benefit Analysis, Cost-Effectiveness Analysis, Diabetes Mellitus
- Abstract
Background: Diabetes prevention trials require large samples and community-based recruitment, which can be protracted and expensive. We analysed the cost-effectiveness of recruitment strategies used in a randomised placebo-controlled supplement trial in adults with prediabetes and overweight or obesity conducted in Sydney, Australia., Methods: Recruitment strategies included advertising through local radio stations and newspapers, television news coverage, online advertising and editorials, advertising in and referral from primary care settings, university- and hospital-based advertising, and attending or hosting local events. For each strategy, the number of expressions of interest, screenings booked, and randomised participants were collated. The percentage contribution from each strategy, overall cost, and cost per participant were calculated., Results: Of 4498 expressions of interest, 551 (12%) were eligible for onsite screening and 401 (9%) were randomised. Recruitment costs totalled AU$218,501, averaging AU$545 per participant. The recruitment strategy was recorded for 49% who expressed interest in the trial, and for 75% randomised into the trial. From these data, advertising on local radio stations was the most cost-effective strategy, contributing 46% of participants at AU$286 per participant, then advertising in and referral from primary care settings (57 participants [19%], AU$1438 per participant). The least cost-effective strategy was television news coverage, which was not targeted to the Sydney-based audience, contributing only six participants (AU$10,000 per participant)., Conclusion: Radio advertising and recruitment through healthcare were the most effective recruitment strategies in this trial. Recruitment strategies should be location-specific and appropriate for the target population, prioritising low-effort high-yield strategies. Trial investigators should seek opportunities for free advertising., Competing Interests: Declaration of Competing Interest TPM received payments for consultancy from Australian Nestle Health Science, served on the VLCD Advisory Board and the NSW Medical Dulaglutide Advisory Board (Lilly), and owns stock in Eli Lilly. IDC chaired the ACTION IO Steering Committee (sponsored by Novo Nordisk). NRF received a research grant for this clinical trial funded by SFI Research. He receives royalties from Penguin Random House for three books, payments for lectures from the Australian Eggs Corporation and Ausmed Education, and payments for consultancy from Novo Nordisk. None of the other authors report any conflicts., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
9. Effects of α-Cyclodextrin on Cholesterol Control and Hydrolyzed Ginseng Extract on Glycemic Control in People With Prediabetes: A Randomized Clinical Trial.
- Author
-
Bessell E, Fuller NR, Markovic TP, Lau NS, Burk J, Hendy C, Picone T, Li A, and Caterson ID
- Subjects
- Adult, Complementary Therapies, Diabetes Mellitus, Type 2 prevention & control, Double-Blind Method, Female, Glycemic Control methods, Humans, Male, Middle Aged, Plant Extracts therapeutic use, Prediabetic State metabolism, alpha-Cyclodextrins therapeutic use, Blood Glucose drug effects, Cholesterol, HDL drug effects, Cholesterol, LDL drug effects, Panax, Plant Extracts pharmacology, alpha-Cyclodextrins pharmacology
- Abstract
Importance: Effective strategies for preventing type 2 diabetes are needed. Many people turn to complementary medicines, but there is little well-conducted scientific evidence to support their use., Objective: To assess the efficacy of α-cyclodextrin for cholesterol control and that of hydrolyzed ginseng for glycemic control in people with prediabetes and overweight or obesity., Design, Setting, and Participants: This 6-month double-blind, placebo-controlled, randomized clinical trial, with a 2 × 2 factorial design, was conducted between July 2015 and October 2018 at 2 locations in Sydney, Australia. Eligible participants were aged 18 years or older, had a body mass index (weight in kilograms divided by height in meters squared) of 25 or higher, and had prediabetes within 6 months of study entry according to the American Diabetes Association guidelines. Data analysis was performed from May to August 2019., Interventions: Participants were randomized to 1 of 4 groups to take active or placebo versions of each supplement (α-cyclodextrin plus hydrolyzed ginseng, α-cyclodextrin plus placebo, placebo plus hydrolyzed ginseng, or placebo plus placebo) for 6 months. All participants received dietetic advice for weight loss., Main Outcomes and Measures: The primary outcomes were the differences in total cholesterol and fasting plasma glucose between groups after 6 months. The primary analysis used the intention-to-treat principle. Multiple predetermined subsample analyses were conducted., Results: A total of 401 participants were eligible for the study (248 women [62%]; mean [SD] age, 53.5 [10.2] years; mean [SD] body mass index, 34.6 [6.2]). One hundred one patients were randomized to receive α-cyclodextrin plus hydrolyzed ginseng, 99 were randomized to receive α-cyclodextrin plus placebo, 101 were randomized to receive placebo plus hydrolyzed ginseng, and 100 were randomized to receive placebo plus placebo. For 200 participants taking α-cyclodextrin compared with 201 participants taking placebo, there was no difference in total cholesterol after 6 months (-1.5 mg/dL; 95% CI, -6.6 to 3.5 mg/dL; P = .51). For 202 participants taking hydrolyzed ginseng compared with 199 participants taking placebo, there was no difference in fasting plasma glucose after 6 months (0.0 mg/dL; 95% CI, -1.6 to 1.8 mg/dL; P = .95). Use of α-cyclodextrin was associated with constipation (16 participants vs 4 participants; P = .006) and cough (8 participants vs 1 participant; P = .02). Use of hydrolyzed ginseng was associated with rash and pruritus (13 participants vs 2 participants; P = .006). Only 37 of 401 participants (9.2%) experienced these adverse events., Conclusions and Relevance: Although they are safe for use, there was no benefit found for either α-cyclodextrin for cholesterol control or hydrolyzed ginseng for glycemic control in people with prediabetes and overweight or obesity., Trial Registration: Australian New Zealand Clinical Trials Registry Identifier: ACTRN12614001302640.
- Published
- 2020
- Full Text
- View/download PDF
10. Effects of alpha-cyclodextrin on cholesterol control and Compound K on glycaemic control in people with pre-diabetes: Protocol for a Phase III randomized controlled trial.
- Author
-
Bessell E, Fuller NR, Markovic TP, Burk J, Picone T, Hendy C, Tan MMC, and Caterson ID
- Subjects
- Adult, Blood Glucose metabolism, Body Weight drug effects, Diabetes Mellitus, Type 2 prevention & control, Female, Humans, Male, Middle Aged, Obesity diet therapy, Obesity metabolism, Overweight drug therapy, Overweight metabolism, Prediabetic State metabolism, Triglycerides metabolism, Cholesterol metabolism, Ginsenosides administration & dosage, Prediabetic State drug therapy, alpha-Cyclodextrins administration & dosage
- Abstract
The prevalence of pre-diabetes and of type 2 diabetes mellitus is increasing. Preventing disease progression is important to improve outcomes. Natural products are becoming popular alternatives to pharmaceutical products for preventative health and treatment of disease; however, the evidence to support the use of natural alternatives for pre-diabetes and type 2 diabetes is lacking. Two such natural medicines include alpha-cyclodextrin (marketed as FBCx), a fibre derived from corn starch that has been found to bind triglycerides in the intestines to prevent its absorption, aiding weight maintenance and lipid control, and hydrolysed ginseng extract (marketed as GINST15), a formula containing high amounts of Compound K, a metabolite of ginsenosides thought to be an active ingredient contributing to the anti-hyperglycaemic effects of ginseng. This paper describes the rationale and design of a 12-month randomized controlled trial to investigate the metabolic effects of these two products in people with pre-diabetes and overweight or obesity. A total of 400 participants will be randomized to one of four groups (FBCx + GINST15, FBCx + placebo, placebo + GINST15, placebo + placebo) for 6 months, followed by 6 months of follow-up. Participants will also receive lifestyle advice for healthy eating and weight loss. Data collected during the trial will include weight, waist circumference, body composition and blood pressure. Blood samples will also be collected to measure lipid profile and glycaemia. If the products are found to improve lipid and glucose levels, it will provide evidence for their use in people with pre-diabetes to help reduce the risk of progression to type 2 diabetes., (© 2019 World Obesity Federation.)
- Published
- 2019
- Full Text
- View/download PDF
11. Dietary fiber intake increases the risk of zinc deficiency in healthy and diabetic women.
- Author
-
Foster M, Karra M, Picone T, Chu A, Hancock DP, Petocz P, and Samman S
- Subjects
- Adult, Aged, Cation Transport Proteins genetics, Cross-Sectional Studies, Diabetes Mellitus, Type 2 genetics, Dietary Fiber administration & dosage, Female, Humans, Middle Aged, Phytic Acid blood, Young Adult, Zinc Transporter 8, Dietary Fiber metabolism, Phytic Acid metabolism, Zinc blood, Zinc deficiency
- Abstract
Phytic acid is a major determinant of zinc bioavailability. Little is known about phytic acid intakes or indices of zinc bioavailability in type 2 diabetes mellitus (DM), a condition that predisposes to zinc deficiency. The aim of this cross-sectional study was to measure and explore the relationships among phytic acid intake, zinc bioavailability, and molecular markers of zinc homeostasis in 20 women with DM compared to 20 healthy women. The phytate/zinc, (calcium)(phytate)/zinc, and (calcium + magnesium)(phytate)/zinc molar ratios were used to indicate zinc bioavailability. Plasma zinc concentrations and zinc transporter (ZnT1, ZnT8, and Zip1) gene expression in mononuclear cells were measured. Participants with DM consumed 1,194 ± 824 mg/day (mean ± SD) phytic acid, an amount similar to the intake of healthy women (1,316 ± 708 mg/day). Bread products and breakfast cereals contributed more than 40 % of the phytic acid intake in each group. A positive relationship was observed in all participants between phytic acid and dietary fiber (r = 0.6, P < 0.001) and between dietary fiber and the (calcium)(phytate)/zinc ratio (r = 0.5, P < 0.001). Compared to the healthy group, the messenger RNA ratio of ZnT1 (zinc export) to Zip1 (zinc import) was lower in participants with DM, which may indicate perturbed zinc homeostasis in the disorder. The plasma zinc concentration was not predicted by age, body mass index, health status, zinc bioavailability, or zinc transporter expression. Healthy and diabetic women consume phytic acid in amounts that are likely to decrease the bioavailability of dietary zinc. Recommendations to consume greater amounts of dietary fiber, much of which is associated with phytate, increase the risk of zinc deficiency.
- Published
- 2012
- Full Text
- View/download PDF
12. Modification of reagents in the EnviroAmp kit to increase recovery of Legionella organisms in water.
- Author
-
Oshiro RK, Picone T, and Olson BH
- Subjects
- DNA, Bacterial isolation & purification, Legionella genetics, Legionella pneumophila genetics, Nucleic Acid Hybridization, Polymerase Chain Reaction methods, Sensitivity and Specificity, Legionella isolation & purification, Legionella pneumophila isolation & purification, Reagent Kits, Diagnostic, Water Microbiology
- Abstract
Organisms of the bacterial genus Legionella, commonly found in aqueous reservoirs, have been associated with Legionnaires' disease (legionella pneumonia, caused by Legionella pneumophila) and Pontiac fever (nonpneumonic legionellosis). EnviroAmp Legionella sample preparation, polymerase chain reaction amplification, and detection kits (Perkin-Elmer Corp.) were developed for rapid detection of DNA from organisms of the genus Legionella and the species L. pneumophila from environmental water samples. The kits are based on molecular techniques incorporating polymerase chain reaction amplification and detection by reverse dot blot hybridization to particular genus and species probes. The manufacturer states that the EnviroAmp Legionella sample preparation, polymerase chain reaction amplification, and detection kits can detect approximately 100 Legionella organisms/mL (10,000 organisms/100 mL) in the original water sample. The sensitivity of the kits was increased to 0.1 colony-forming units/mL (10 colony-forming units/100 mL), at least for cultured organisms, by modifying the EnviroAmp Legionella sample preparation kit protocol. Data obtained in this study indicated that sample volume could be increased from 100 to 1000 mL (in the absence of interfering substances such as humic acid) and DNA extraction volume could be decreased from 2 to 0.5 mL to increase the ability of the kit to detect lower numbers of Legionella spp. or L. pneumophila per volume.
- Published
- 1994
- Full Text
- View/download PDF
13. Randomized trial of taurine supplementation for infants less than or equal to 1,300-gram birth weight: effect on auditory brainstem-evoked responses.
- Author
-
Tyson JE, Lasky R, Flood D, Mize C, Picone T, and Paule CL
- Subjects
- Amino Acids blood, Clinical Trials as Topic, Humans, Infant, Newborn, Random Allocation, Reaction Time drug effects, Taurine blood, Brain Stem drug effects, Evoked Potentials, Auditory drug effects, Food, Formulated, Infant Food, Infant, Low Birth Weight, Taurine administration & dosage
- Abstract
Taurine may be important to the developing eye and brain of the small preterm infant. A blinded randomized trial was conducted to determine whether taurine supplementation of healthy infants of less than or equal to 1,300 g birth weight until their discharge from the hospital increases their growth rate, neurobehavioral development, electroretinographic development, or maturation of auditory brainstem-evoked responses. Infants were fed with Similac Special Care as desired, which was prepared to contain less than 5 mg/L of taurine or 45 mg/L of taurine, a concentration similar to that of human milk. Infants who did not receive taurine supplementation (n = 19) and those who did (n = 18) were similar with respect to condition at study entry, caloric intake, and growth rates throughout the study, and electroretinographic findings and scores on the Brazelton Behavioral Assessment Scale at 37 weeks' postmenstrual age. Infants who received taurine supplementation had greater overall plasma taurine concentrations. The group receiving taurine supplementation also had more mature auditory-evoked responses at 37 weeks' postmenstrual age with a modest (0.2 to 0.5 ms) but consistent reduction (P less than .05) in the interval between stimulus and response at two different stimulation rates. Although further study is needed, taurine intake appears to influence auditory system maturation of preterm infants.
- Published
- 1989
14. Effects of early malnutrition on tail pinch-induced behavior of the rat.
- Author
-
Picone TA and Hall RD
- Subjects
- Animals, Female, Humans, Male, Pain, Physical Stimulation, Rats, Tail, Feeding Behavior, Protein Deficiency psychology, Stress, Psychological
- Published
- 1979
- Full Text
- View/download PDF
15. Medium-chain triglycerides in infant formulas and their relation to plasma ketone body concentrations.
- Author
-
Wu PY, Edmond J, Auestad N, Rambathla S, Benson J, and Picone T
- Subjects
- 3-Hydroxybutyric Acid, Acetoacetates blood, Fetal Blood metabolism, Humans, Hydroxybutyrates blood, Infant, Newborn, Infant, Premature, Ketosis blood, Milk, Human analysis, Dietary Fats administration & dosage, Infant Food analysis, Ketone Bodies blood, Triglycerides administration & dosage
- Abstract
A mild ketosis is known to prevail in the mother, fetus, and newborn infant during the 3rd trimester and in the early neonatal period. It has been shown that during an equivalent period in the rat ketone bodies are readily oxidized and serve as key substrates for lipogenesis in brain. Since medium-chain triglycerides are known to be ketogenic, preterm infants may benefit from dietary medium-chain triglycerides beyond the point of enhanced fat absorption. Our objective was to determine the ketogenic response in preterm infants (gestational age: 33 +/- 0.8 wk) fed three different isocaloric formulas by measuring the concentrations of 3-hydroxybutyrate and acetoacetate in the plasma of these infants. At the time of entrance to the study the infants were receiving 110 kcal/kg/24 h. Study I (11 infants): the infants were fed sequentially in the order; PM 60/40 (PM), Special Care Formula (SCF), and Similac 20 (SIM). In SCF greater than 50% of the fat consists of medium-chain length fatty acids while PM and SIM contain about 25%. The concentration of 3-hydroxybutyrate in plasma was significantly higher when infants were fed SCF than PM and SIM [0.14 +/- 0.03, 0.06 +/- 0.01, and 0.05 +/- 0.01 mM, respectively (p less than 0.01)]. Study II (12 infants); the infants were fed SCF, then SIM, or the reverse. The concentration of acetoacetate in plasma was 0.05 +/- 0.01 and 0.03 +/- 0.01 mM when infants were fed SCF and SIM, respectively (0.1 greater than p greater than 0.05). The concentrations of 3-hydroxybutyrate in plasma were similar to those measured in study I for the respective formulas.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1986
- Full Text
- View/download PDF
16. Pregnancy outcome in North American women. II. Effects of diet, cigarette smoking, stress, and weight gain on placentas, and on neonatal physical and behavioral characteristics.
- Author
-
Picone TA, Allen LH, Olsen PN, and Ferris ME
- Subjects
- Anthropometry, Connecticut, Female, Gestational Age, Humans, Infant, Low Birth Weight, Infant, Newborn, Models, Biological, Pregnancy Complications etiology, Pregnancy Trimester, Second, Body Weight, Diet adverse effects, Infant, Newborn, Diseases etiology, Nervous System Diseases etiology, Placenta pathology, Pregnancy, Smoking, Stress, Psychological complications
- Abstract
This study evaulated the effects of diet, weight gain (low = LWG, less than or equal to 15 lb; adequate greater than 15 lb), smoking, and stress on the pregnancy outcomes of 60 women. LWG mothers, compared to adequate weight gain, had lower calorie intakes, shorter gestations (0.5 wk, Dubowitz) smaller placentas (345 +/- 65 versus 373 +/- 75 g), and infants with lower birth weight 2640 +/- 329 versus 3192 +/- 307 g), ponderal indices (2.37 versus 2.62), and growth rates. Mothers who smoked had increased calorie intake, but showed no alterations in gestational age of infants or placenta weights. Infants of smokers weighed less than those of nonsmokers (2875 +/- 522 versus 309 +/- 511 g), but had a normal ponderal index. LWG or smoking were associated with impaired motor performance, visual habituation and orientation, and reflexes. Smoking adversely affected auditory habituation and orientation, and autonomic regulation. LWG and smoking have significant, but separate, detrimental effects on pregnancy outcome.
- Published
- 1982
- Full Text
- View/download PDF
17. Pregnancy outcome in North American women. I. Effects of diet, cigarette smoking, and psychological stress on maternal weight gain.
- Author
-
Picone TA, Allen LH, Schramm MM, and Olsen PN
- Subjects
- Connecticut, Energy Intake, Female, Humans, Prospective Studies, Body Weight, Diet, Pregnancy, Smoking, Stress, Psychological complications
- Abstract
This study examined the roles of diet, cigarette smoking, and psychological stress in pregnancy weight gain. The 60 were selected by defined criteria to minimize variation in anthropometric, socioeconomic, and medical variables which also affect weight gain. To maximize variation in weight gain, subjects were also selected on the basis of low weight gain (less than or equal to 15 lb) and adequate weight gain (greater than 15 lb). Each weight gain group contained smokers and nonsmokers. Smokers consumed more calories than nonsmokers (2119 versus 1810 kcal/day, p less than 0.01). for nonsmokers, differences between the intakes of low weight gain (1617 kcal/day) and adequate weight gain (1905 kcal/day) women were significant (p less than 0.02) and calorie intake was correlated with weight gain (r=0.44 p, less than 0.02). Psychological stress negatively correlated with weight gain (r=0.37, p less than 0.01) but not with calorie intake. We conclude that low weight gain is associated with a lower food intake. In contrast, smoking and stress may cause low weight gain by reducing the utilization of calories for weight gain.
- Published
- 1982
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.