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22 results on '"Peruchon, L."'

4. Kinetics and mechanism of photocatalytic reforming of glycerol over Pt/TiO2 and Ni/TiO2 photocatalysts

Author

Lorito, D., Brochier, C., Peruchon, L., Lamaa, L., Geantet, C., Lorentz, C., Puzenat, E., IRCELYON, ProductionsScientifiques, IRCELYON-Catalyse Hétérogène pour la Transition Energétique (CATREN), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and IRCELYON-RMN (RMN)

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

RMN+ECI2D+DLR:CGE:CLO:EPU; International audience; H2 production from renewable sources is a potential key solution to energetic transition. Glycerol is interesting due to the high H-content. In the present study Pt and Ni supported TiO2 photocatalysts where tested during reforming of alcohol solutions. Combined GC analysis helps to identify intermediates and understand the reaction kinetics.

Published
2019

5. QAIcar project: Indoor Air Quality in vehicle cabin- odor and microorganism treatment

Author

Guillard, C., Hamandi, M., Vernoux, P., Gilbert, C., Kaper, H., El-Hajem, M., Pajot, K., Pintat, B., Lamaa, L., Peruchon, L., Brochier, C., IRCELYON-Catalytic and Atmospheric Reactivity for the Environment (CARE), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and IRCELYON, ProductionsScientifiques

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

SSCI-VIDE+CARE+CGU:MHM:PVE; International audience; Several studies have shown that volatile organic compounds (VOCs) can be concentrated in the car, enclosed and confined at rates higher than those of outdoor air [1]. Thus, the air quality is almost always less good inside and is degraded according to external parameters, ex. confined areas of traffic (eg tunnels) [2] or depending on the season (increase in VOC by 40% during summer, due to high temperatures). The presence of these VOCs in vehicle cabin air is responsible for allergies, respiratory problems, skin problems. As people spend a lot of their time in their vehicle [3], for example, in France, 73% of active population (18 million people) use their vehicles every day to go to work and spends an average of 78 minutes per day that is 3 years and 4 months of their life! [4], it is essential to develop an efficient device to remove them. Indeed, most of the actual depollution systems are based on adsorption of these compounds to store them.The QAIcar project aims to develop an air handling equipment dedicated to the automotive interior allowing to destroy microorganisms and VOCs.The project includes 3 innovations:- the coupling of catalysis at room temperature with photocatalysis- the development of a bactericidal luminous textile which will serve support for the coupling of catalyst and photocatalyst.- the concept of a compact reactor integrating the active luminous textile into a multilayer.This project brings together three academic laboratories, IRCELYON, CIRI and LMFA, a small and medium-sized enterprise, Brochier technologies, a mid-size companies, EFI Lighting who is the project leader and two big groups, St; Gobain CREE and the automotive manufacturer, PSA Group.In the poster will be describe the existing locks motivating the project, the objectives, the consortium and the structuring of the project as well as the first results[1] Delaunay C., Goupil G., Ravelomanantsoa H., Person A., Mazoué S., Morawski F., , Pollution atmosphérique 2012 ; 215 : 247 – 258[2] De Pas A., Boissavy-Vineau M., Bull. Epidémiol. Hebd. 2013 ; (1-2) : 17[3] D. Müller, D. Klingelhöfer, S. Uibel, D. A. Groneberg, (2011) J. Occup. Med. Toxicol, 6, 1701-1709[4] Enquête globale transport, STIF, janvier 2013 ; http://www.lievreoutortue.com/dans-votre-vie-combien-de-temps-passerez-vous-dans-votre-voiture/

Published
2018

6. TiO2 Coated Luminous Textile : Ideal Photocatalytic System For Pollutant Removal From Indoor Air In Vehicule Cabin

Author

Hamandi, M., Lamaa, L., Peruchon, L., Brochier, C., Vernoux, P., Guillard, C., IRCELYON, ProductionsScientifiques, IRCELYON-Caractérisation et remédiation des polluants dans l'air et l'eau ( CARE ), Institut de recherches sur la catalyse et l'environnement de Lyon ( IRCELYON ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), IRCELYON-Catalytic and Atmospheric Reactivity for the Environment (CARE), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[ CHIM.CATA ] Chemical Sciences/Catalysis, [CHIM.CATA] Chemical Sciences/Catalysis, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [SDE.ES]Environmental Sciences/Environmental and Society, [ SDE.ES ] Environmental Sciences/Environmental and Society
Abstract

SSCI-VIDE+CARE+MHM:PVE:CGU; International audience; The photocatalytic process is an efficient method to remove chemical and microbiological pollutants from indoor air in automotive cabin. In the present work, luminous textile was used at first as light source in the photocatalytic degradation of a mixture of pollutants and compared to classical UV lamp. Then, it was used both as light source and a (photo)catalytic support. In this case, the durability and the deposition quality have been optimized in order to preserve good photocatalytic efficiency. This innovative textile combining light source with photocatalyst has advantage of allowing the development of compact reactor with considerable gain of energy.

Published
2018

7. New compact technology for cabin air purification based on photocatalytic optical fiber textile

Author

Lamaa, L., Peruchon, L., Brochier, C., Guillard, C., IRCELYON-Catalytic and Atmospheric Reactivity for the Environment (CARE), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and IRCELYON, ProductionsScientifiques

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

SSCI-VIDE+CARE+LLM:CGU; International audience; None

Published
2016

8. Innovative photocatalytic optical fiber textile: for water and air treatment

Author

Peruchon, L., Lamaa, L., Brochier, C., Puzenat, E., Guillard, C., IRCELYON, ProductionsScientifiques, IRCELYON-Catalytic and Atmospheric Reactivity for the Environment (CARE), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and IRCELYON-Catalyse Hétérogène pour la Transition Energétique (CATREN)

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

SSCI-VIDE+CARE:ECI2D+LLM:EPU:CGU; International audience; None

Published
2016

9. Photocatalytic luminous materials for water and air treatment

Author

Indermühle, C., Puzenat, E., Degrave, R., Cockx, A., Schmitz, P., Peruchon, L., Brochier, C., Guillard, C., IRCELYON-Catalyse Hétérogène pour la Transition Energétique (CATREN), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), IRCELYON-Catalytic and Atmospheric Reactivity for the Environment (CARE), and IRCELYON, ProductionsScientifiques

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

SSCI-VIDE+CARE:ECI2D+EPU:CGU; International audience; None

Published
2015

10. development of luminous textile for wastewater treatment by photocatalysis

Author

Indermühle, C., Puzenat, E., Degrave, R., Cockx, A., Schmitz, P., Peruchon, L., Brochier, C., Guillard, C., IRCELYON, ProductionsScientifiques, IRCELYON-Catalyse Hétérogène pour la Transition Energétique (CATREN), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and IRCELYON-Catalytic and Atmospheric Reactivity for the Environment (CARE)

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

SSCI-VIDE+CARE:ECI2D+EPU:CGU; International audience; None

Published
2015

11. Optical fibers containing textiles as new photocatalytic materials

Author

BOURGEOIS, P.A, Puzenat, E., Peruchon, L., Malhomme, D., AIR (AIR), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and IRCELYON, ProductionsScientifiques

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

International @ AIR+EPU:CGU; International audience

Published
2012

12. Photocatalytic removal of VOCs by a new textile composed of optical fibers

Author

Bourgeois, P., Simonet-Beauchesne, F., Peruchon, L., Puzenat, E., Malhomme, C., Brochier, C., Deflin, E., Guillard, C., Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and IRCELYON, ProductionsScientifiques

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

National

Published
2010

13. Photocatalytic removal of VOCs by a new textile composed of optical fibers

Author

Bourgeois, P. A., Puzenat, E., Malhomme, D., Peruchon, L., Deflin, E., Brochier, C., Guillard, C., Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and IRCELYON, ProductionsScientifiques

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

international

Published
2010

14. Photocatalytic VOCs degradation by a new textile composed of optical fibers

Author

Bourgeois, P. A., Puzenat, E., Malhomme, D., Peruchon, L., Deflin, E., Brochier, C., Guillard, C., Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and IRCELYON, ProductionsScientifiques

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

international

Published
2010

15. New perspectives in photocatalytic set up design by using optical fiber containing textiles

Author

Puzenat, E., Bourgeois, P., Peruchon, L., Malhomme, D., Deflin, E., Brochier, C., Guillard, C., IRCELYON, ProductionsScientifiques, Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

International

Published
2010

16. Photocatalytic properties of TiO2 thin films used in commercialized self-cleaning glasses

Author

Peruchon, L., Puzenat, E., Herrmann, J. M., Guillard, C., IRCELYON, ProductionsScientifiques, Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and 22-25 septembre 2008

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

international

Published
2008

17. Characterization of the photocatalyst Bioclean using Langmuir-Blodgett technique to control thickness of stearic acid multilayers. Importance of spectral emission to define standard test

Author

Peruchon, L., Puzenat, E., Girard-Egrot, A., Blum, L., Herrmann, J.-M., Guillard, C., Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Centre National de la Recherche Scientifique (CNRS)-École Supérieure Chimie Physique Électronique de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon

Subjects
ComputingMilieux_MISCELLANEOUS, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
Abstract

International audience

Published
2008

18. Characterization of the photocatalytic performance of self-cleaning glass through the degradation of different organic compounds ; influence of different physico-chemical parameters

Author

Puzenat, E., Peruchon, L., Guillard, C., Herrmann, J. M., Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), 14-15 juin 2007, and IRCELYON, ProductionsScientifiques

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

international; International audience

Published
2007

19. Photocatalysis : from fundamentals to self-cleaning glass applications

Author

Herrmann, J. M., Peruchon, L., Puzenat, E., Guillard, C., Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), 8-9 octobre 2007, IRCELYON, ProductionsScientifiques, and P.BAGLIONI P., CASSAR L.

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [SDE.ES] Environmental Sciences/Environmental and Society, [CHIM.CATA]Chemical Sciences/Catalysis, [SDE.ES]Environmental Sciences/Environmental and Society, ComputingMilieux_MISCELLANEOUS
Abstract

international; International audience

Published
2007

20. Coupling of photocatalysis and catalysis using an optical fiber textile for room temperature depollution.

Author

Molino, A., Hamandi, M., Grosjean, R., Dappozze, F., Lamaa, L., Peruchon, L., Brochier, C., Dembélé, K., El Hajem, M., Vernoux, P., Guillard, C., and Kaper, H.

Subjects
*TEXTILE fibers, *OPTICAL fibers, *PHOTOCATALYTIC oxidation, *CATALYSIS, *CATALYST supports, *CERIUM oxides
Abstract

Herein, we investigate the interplay between a photocatalyst (TiO 2) and a catalyst (Pt/TiO 2 and Pt/CeO 2) for the oxidation of formaldehyde and toluene at room temperature. A luminous textile is used as support and as light source for the photocatalyst. Our results indicate that the presence of the catalyst and the photocatalyst increases the catalytic performance for the oxidation of formaldehyde, while the photocatalytic performance for toluene oxidation decreases. The overall performance (toluene and formaldehyde degradation) of the system can be optimized with respect to the choice of support for the catalyst (e.g. TiO 2 or CeO 2), the quantity of Pt used, and the ratio between the catalyst and photocatalyst. In addition, different configurations of the photocatalyst and the catalyst on the textile are studied: under leaching and flow-through gas streams, catalyst and photocatalyst deposition on the same and opposite site of the textile are tested. The performance of the system can be optimized by adapting a configuration where the gas stream goes through the textile, while the deposition side of the catalyst and/or photocatalyst with respect to the gas stream is of minor importance. Schematic illustration of the degradation mechanism of volatile organic compounds (VOC) by coupling photocatalysis and catalysis using a luminous textile with optical fibers. [Display omitted] • Room temperature oxidation of toluene and formaldehyde. • Coupling of photocatalyst and catalyst on an optical fiber textile enhances formaldehyde oxidation. • Pt/CeO 2 shows higher performance than Pt/TiO 2 for catalytic formaldehyde oxidation at room temperature. • Flow-through conditions are more effective than leaching gas streams. [ABSTRACT FROM AUTHOR]

Published
2022
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21. Understanding Aging Mechanisms in the Context of UV Irradiation of a Low Fouling and Self-Cleaning PVDF-PVP-TiO 2 Hollow-Fiber Membrane.

Author

Roubaud E, Maréchal W, Lorain O, Lamaa L, Peruchon L, Brochier C, Mendret J, Mericq JP, Brosillon S, Faur C, and Causserand C

Abstract

In the context of designing a photocatalytic self-cleaning/low-fouling membrane, the stability of PVDF-PVP-TiO 2 hollow-fiber membranes under UV irradiation has been studied. The effect of irradiation power, aqueous environment composition and fouling state on the properties of the membranes has been investigated. With this aim, SEM observations, chemical analysis and tensile strength measurements have been conducted. The results indicate that pristine membranes that undergo UV irradiation in ultra-pure water are significantly degraded due to attacks of OH° radicals. However, when methylene blue, used as a model pollutant, is introduced in the aqueous environment, OH° radicals preferentially react with this molecule rather than the membranes, successfully preserving the original properties of the latter. The presence of an adsorbed BSA layer (pre-fouling by immersion) on the surface of the membrane delays membrane aging, as the BSA layer is degraded by radicals instead of the membrane material. The degradation of the BSA layer also validates the self-cleaning properties of the membrane. However, when membranes are pre-fouled by filtration of a 2 g/L BSA solution, delay to aging is less. This is because OH° radicals do not reach BSA molecules that are trapped inside the membrane pores, and therefore react with the membrane material.

Published
2022
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22. Synthesis and antiproliferative activity of basic ethers of 1,2-dihydropyrrolo[1,2-a]indole, 6H-isoindolo[2,1-a]indole, and 6H-benz[5,6]isoindolo[2,1-a]indole.

Author

Guillaumel J, Léonce S, Pierré A, Renard P, Pfeiffer B, Peruchon L, Arimondo PB, and Monneret C

Subjects
Animals, Cell Line, Tumor, DNA Topoisomerases, Type I drug effects, DNA Topoisomerases, Type II drug effects, Leukemia, Experimental drug therapy, Mice, Structure-Activity Relationship, Antineoplastic Agents chemical synthesis, Antineoplastic Agents pharmacology, Ethers chemical synthesis, Ethers pharmacology, Indoles chemical synthesis, Indoles pharmacology, Pyrroles chemical synthesis, Pyrroles pharmacology
Abstract

Monobasic ethers of 1,2-dihydropyrrolo[1,2-a]indole, 6H-isoindolo[2,1-a]indole, and 6H-benz[5,6]isoindolo[2,1-a]indole and bis-basic ethers of 6H-isoindolo[2,1-a]indole were prepared using an intramolecular Wittig cyclization as a key step. All these compounds were firstly evaluated for their cytotoxicity effects against L1210 cell line. Only the tetracyclic bis-basic ether 14d displayed submicromolar cytotoxic effect. Moreover, despite the fact that the presence of these two amino side chains in 14c, 14d, and 14f led to strong DNA binding effect, they are not topoisomerase II inhibitors. Among the monobasic ethers 14a, 14b, 22, and 29, which do not bind to DNA, the pentacyclic analog 29 exhibited micromolar cytotoxic activity against L1210 and HT-29 cell lines and induced a weak topoisomerase II inhibition.

Published
2003
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