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8 results on '"Perla Román-Bravo"'

3. Efficient Synthesis of β-Aryl-γ-lactams and Their Resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen

Author

Iris J. Montoya-Balbás, Berenice Valentín-Guevara, Estefanía López-Mendoza, Irma Linzaga-Elizalde, Mario Ordoñez, and Perla Román-Bravo

Subjects
β-aryl-γ-lactams, Michael addition, resolution, (S)-naproxen, baclofen, phenibut, Organic chemistry, QD241-441
Abstract

An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained, followed by the reduction of the γ-nitroester in the presence of Raney nickel and the subsequent saponification/decarboxylation reaction. The utility of this methodology was highlighted by the preparation of enantiomerically-pure (R)- and (S)-Baclofen hydrochloride.

Published
2015
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4. N-(2-Pyridylmethyl)phthalimide

Author

Olga Garduño-Beltrán, Perla Román-Bravo, Felipe Medrano, and Hugo Tlahuext

Subjects
Crystallography, QD901-999
Abstract

In the title compound, C14H10N2O2, the phtalimide and 2-pyridylmethyl units are almost perpendicular, with an interplanar angle of 85.74 (2)°. In the crystal, molecules are linked by weak C—H...O interactions, forming chains running along the b axis. The packing is further stabilized by offset π–π interactions between adjacent pyridine rings, with a centroid–centroid distance of 3.855 (2) Å.

Published
2009
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5. Efficient Synthesis of β-Aryl-γ-lactams and Their Resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen

Author

Mario Ordóñez, Iris J. Montoya-Balbás, Berenice Valentín-Guevara, Irma Linzaga-Elizalde, Perla Román-Bravo, and Estefanía López-Mendoza

Subjects
Naproxen, (S)-naproxen, Lactams, Decarboxylation, Hydrochloride, baclofen, Pharmaceutical Science, Medicinal chemistry, Article, Catalysis, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, Michael addition, Drug Discovery, medicine, Organic chemistry, Physical and Theoretical Chemistry, Nitromethane, Chemistry, Aryl, Organic Chemistry, resolution, Stereoisomerism, β-aryl-γ-lactams, phenibut, Raney nickel, Chemistry (miscellaneous), Michael reaction, Molecular Medicine, Saponification, medicine.drug
Abstract

An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained, followed by the reduction of the γ-nitroester in the presence of Raney nickel and the subsequent saponification/decarboxylation reaction. The utility of this methodology was highlighted by the preparation of enantiomerically-pure (R)- and (S)-Baclofen hydrochloride.

Published
2015
Full Text
View/download PDF

6. N-(2-Pyridylmethyl)phthalimide

Author

Perla Román-Bravo, Felipe Medrano, Hugo Tlahuext, and Olga Garduño-Beltrán

Subjects
Crystal, lcsh:Chemistry, chemistry.chemical_compound, Crystallography, chemistry, lcsh:QD1-999, Pyridine, Perpendicular, General Materials Science, General Chemistry, Condensed Matter Physics, Bioinformatics, Organic Papers
Abstract

In the title compound, C14H10N2O2, the phtalimide and 2-pyridylmethyl units are almost perpendicular, with an interplanar angle of 85.74 (2)°. In the crystal, molecules are linked by weak C—H...O interactions, forming chains running along the b axis. The packing is further stabilized by offset π–π interactions between adjacent pyridine rings, with a centroid–centroid distance of 3.855 (2) Å.

Published
2009

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