47 results on '"Pavlova Y"'
Search Results
2. The Effect of Prometheus Device on Laboratory Markers of Inflammation and Tissue Regeneration in Acute Liver Failure Management
- Author
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Rocen, M., Kieslichova, E., Merta, D., Uchytilova, E., Pavlova, Y., Cap, J., and Trunecka, P.
- Published
- 2010
- Full Text
- View/download PDF
3. Hepatocyte growth factor and antibodies to HLA and MICA antigens in heart transplant recipients
- Author
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Pavlova, Y. A., Malek, I., Honsova, E., Netuka, I., Sochman, J., Lodererova, A., Kolesar, L., Striz, I., Skibova, J., and Slavcev, A.
- Published
- 2010
- Full Text
- View/download PDF
4. Coulomb interaction controlled room temperature oscillation of tunnel current in porous Si
- Author
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Afonin, V. V., Gurevich, V. L., Laiho, R., Pavlov, A., and Pavlova, Y.
- Published
- 1998
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5. Distribution of KIR genes in the Czech population
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Pavlova, Y., Kolesar, L., Striz, I., Jabor, A., and Slavcev, A.
- Published
- 2008
6. PIN130 COST-EFFECTIVENESS ANALYSIS OF CEFTAZIDIME/AVIBACTAM FOR THE TREATMENT OF ADULTS WITH COMPLICATED URINARY TRACT INFECTIONS IN BULGARIA
- Author
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Djambazov, S.N., Slavchev, G., Encheva-Malinova, M., Pavlova, Y., and Vekov, T.
- Published
- 2019
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7. 1225P - THOR-707, a novel not-alpha IL-2, promotes all key immune system anti-tumoral actions of IL-2 without eliciting vascular leak syndrome (VLS)
- Author
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Milla, M.E., Ptacin, J.L., Ma, L., Caffaro, C.E., Aerni, H.R., San Jose, K.M., Pena, M.J., Herman, R.W., Pavlova, Y., Chen, D.B., Ismaili, T.K., Li, S., Nguyen, J., Singh, N., Shawver, L.K., Koriazova, L.K., and Joseph, I.B.
- Published
- 2019
- Full Text
- View/download PDF
8. Application of whey protein hydrolysate as a technological additive in the sour cream production
- Author
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Nikolina Anna, Neverova Olga, Rogozinnikova Irina, Pavlova Yana, and Shamilov Rustam
- Subjects
Microbiology ,QR1-502 ,Physiology ,QP1-981 ,Zoology ,QL1-991 - Abstract
In the context of economic sanctions, the problem of supplying food additives, including stabilizers and thickeners, which are important in the production of fermented milk products, remains relevant for many enterprises; the development of a fermented milk product – sour cream, using whey protein hydrolysate as a technological additive is relevant. The purpose of the research was to study the effect of whey protein hydrolysate on the technological process of manufacturing a fermented milk product, sour cream, and the quality indicators of the final product. The results of the acidity study showed that in the experimental samples, the ripening process occurred faster than in the control sample. Based on the results of the research, it can be concluded that whey protein hydrolysate can be used as a technological additive in the production of fermented milk products to improve quality indicators.
- Published
- 2024
- Full Text
- View/download PDF
9. The effectiveness of growing repair heifers-daughters of different servicing bulls
- Author
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Gorelik O.V., Kharlap S.Yu., Pavlova Ya.S., Galushina P.S., Bykova O.A., and Kaneva E.V.
- Subjects
Microbiology ,QR1-502 ,Physiology ,QP1-981 ,Zoology ,QL1-991 - Abstract
Since 2021, the Sverdlovsk region has switched to the cultivation and use of dairy cattle of the Holstein breed, obtained as a result of long-term use of the global gene pool of Holstein bulls. Evaluation of the effectiveness of rearing repair heifers from different servicing bulls is relevant and has practical significance. As a result of the conducted research, it was found that repair heifers increased their live weight with age, which by the age of 18 months reached from 508.0 kg (daughter of Thunderlight bull) to 529.3 kg (daughter of Seiner bull). The daughters of the Seiner bull have a higher growth rate. The daughters of the Thunderlight bull had lower live weight indicators for growth periods. The patterns of change in the average daily body weight gains in heifers-daughters of the evaluated servicing bulls were the same and corresponded to the general patterns of animal growth and development. The cultivation of repair young animals on the farm is profitable at a profitability level of 16.5-21.6%. Thus, the servicing bull has an impact on the growth and development of repair heifers, daughters, who are used to renew the herd. They differ in their features, despite the general patterns of growth and have different growth rates.
- Published
- 2024
- Full Text
- View/download PDF
10. Evaluation of the productive qualities of Holstein dairy cattle
- Author
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Gorelik O.V., Kharlap S.Yu., Pavlova Ya.S., Galushina P.S., Bykova O.A., and Kaneva E.V.
- Subjects
Microbiology ,QR1-502 ,Physiology ,QP1-981 ,Zoology ,QL1-991 - Abstract
Sverdlovsk region is one of the leading regions in milk production. The main livestock of dairy cattle is represented by the Holstein breed, obtained as a result of long-term use of the global gene pool of Holstein servicing bulls. The assessment of the productive qualities of dairy cattle of the Holstein breed, including consideration of linear origin, is relevant and has practical significance. As a result of the conducted research, it was found that the farm is dominated by the number of cows of the Vis Back Ideal line, which account for more than 65.8% of the total number of cows. There is an unreliable insignificant difference in favor of cows of the Reflection Sovering line between groups of animals of different genealogical lines for the first and third lactation. With age, there is a decrease in milk quality indicators, such as FMF and PMF in milk from cows of all genealogical lines, which confirms the natural negative relationship between milk yield and milk quality indicators. The absorption of dairy black-and–white cattle of the domestic breed by the gene pool of the world’s most abundantly dairy breed, the Holstein, led to an increase in milk yields and the milk yield coefficient of these cows is much higher than 1000 kg. Despite the fact that the difference in milk yield is unreliable and the variation of the trait within each group along the line is quite significant, this is indicated by indirect traits such as the coefficient of milk production, milk yield for full-age lactation, etc., origin affects the productive qualities of cows.
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- 2024
- Full Text
- View/download PDF
11. Preparation of dietary fiber from oats
- Author
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Nikolina Anna, Zinina Oksana, Neverova Olga, Sharaviev Pavel, Pavlova Yana, and Lopayeva Nadezhda
- Subjects
Microbiology ,QR1-502 ,Physiology ,QP1-981 ,Zoology ,QL1-991 - Abstract
Today, there is a trend of increasing demand for products made from plant materials, especially the demand for plant-based drinks. Many enterprises adhere to the technology of producing these drinks from whole grain raw materials. In this regard, at the enterprises, producing these products, the volumes of secondary plant raw materials, meal, have increased, the issue of processing of which has not yet been fully resolved. Sensory and physicochemical characteristics of whole grain oats were determined, and the results showed that this raw material is suitable for subsequent processing. Based on the results of the research, it was established that the prepared dietary fiber preparation from oats has high functional and technological indicators and a degree of hydration, as well as low moisture content, which increase the yield and improve the quality of the finished product. These results allow us to conclude that the obtained dietary fiber preparation can be used in the future for food production.
- Published
- 2024
- Full Text
- View/download PDF
12. Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
- Author
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Fauchier, L., Greenlaw, N., Ferrari, R., Ford, I., Fox, K. M., Tardif, J. -C., Tendera, M., Steg, P. G., Sokn, F. J., Reid, C., Lang, I., Van den Branden, F., Cesar, L. M., Mattos, M. A., Nazar Luqman, H., Goudev, A., Dorian, P., Hu, D., Widimsky, P., Hassager, C., Danchin, N., Kaab, S., Vardas, P., Sulaiman, K. J., Al Mahmeed, W., Al Suwaidi, J., Al Rashdan, I., Abdulkader, F., Merkely, B., Kaul, U., Daly, K., Tavazzi, L., Jang, Y., Erglis, A., Laucevicius, A., Jamaluddin, A. N., Gamba, M. A., Tulevski, I. I., Stepinska, J., Morais, J., Macarie, C., Oganov, R., Shalnova, S., Al-Zaibag, M., Hou, M. K., Kamensky, G., Fras, Z., Kanic, V., Naidoo, D. P., Zamorano, J. L., Rickli, H., Jaussi, A., Sriratanasathavorn, C., Kalra, P., Lutai, M., Oleksandr, Nguyen, L. V., Henry, R., Ahuad Guerrero, A., Basara, M., Belcastro, F., Bertarini, J. A., Cazenave, C., Dreycopp, H., Egido, J., Estrella, J., Garofalo, D., Giordano, J., Lagioia, H., Lago, N., La Greca, R., Lema, L., Lopez Cabanillas, N., Luquez, H., Miller, C., Prada, E., Rodenas, P., Schena, R. G., Suarez, G., Tomatti, A., Colquhoun, D. M., Conradie, A., Cox, S., Cross, D., Fathi, R., Fitzgerald, B., Hamilton-Craig, I., Holt, G., Jayasinghe, S. R., Mai, N., Moolman, J., Motyer, R. A., Phillips, K., Rafter, A., Rahman, A., Rainbird, A., Scalia, G., Taylor, A., West, P., Alford, K., Amor, R., Astridge, P., Bastian, B., Bates, F., Doohan, M. M., Du Plooy, J., Ford, J. C., Kanagaratnam, L., Khoury, V., Parkin, R., Rogers, J., Sceats, G., Waldman, A., Wang, D., Wright, S., Ardill, J., Aylward, P., Beltrame, J. F., Bradley, J., Heddle, W., Joseph, M., Rajendran, S., Varughese, S., Brice, E., Hockings, B., Janssen, J., Kozlowski, A., O'Shea, J., Playford, D. A., Woollard, K., Ajani, A., Barron, G., Better, N., Chan, B., Chan, R., Cotroneo, J., Counsell, J. T., Eccleston, D. S., Forge, B. H. R., Hamer, A., Horrigan, M., Jelinek, V. M. J., Lew, R., O'Donnell, D., Panetta, F., Sebastian, M., Soward, A., Srivastava, P., Strathmore, N. F., Sylivris, S., Szto, G., Veth, V., Yip, T., Badr-Eslam, R., Kleemann, L., Steurer, G., Morz-Proszowski, B., Auhser, F., Teleky, U., Sepp, G., Beinhauer, A., Kero, D., Lavicka, C., Perger, T., Hadjiivanov, V., Feldner-Busztin, M., Mika, R., Filip, W., Mahr, A., Toplak, J., Millauer, M. G., Haralambus, P., Walcher, K., Karner, K. H., Ziak, E., Painsipp, P., Frank, U., Suntinger, A., Gritsch, W., Bode, G., Herrmann, R., Raffelsberger, R., Topf, H., Moser, E., Fochterle, J., Honsig, T., Mayr, K., Mayr, H., Kaserbacher, R., Dzien, A., Galehr, E., Felbermayer, M., Schwarz, R., Amini, R., Appeltants, H., Ballet, A., Bar, J. -P., Beckers, J., Bergen, J. -M., Berkenboom, G., Bernard, X., Bouvy, T., Briki, R., Claeys, M., Dascotte, Y., Davin, L., De Backer, T., De Keyser, F., De Meester, A., De Ridder, S., Dendale, P., Denef, K., Dhondt, E., Emonts, M., Geraedts, J. T. M., Goethals, M., Gregoire, J. -M., Haine, E., Herbots, T., Hoffer, E., Hutse, W. H. J., Kassab, A., Lafontaine, P., Lancellotti, P., Lefebvre, P., Lesseliers, H., Lozano, A., Maamar, R., Martinez, C., Noel, J. -F., Odent, G., Pasquet, A., Peperstraete, B., Purnode, P., Rogowsky, A., Rosseel, M., Salembier, J. -P., Surmont, P., Thermol, P., Vandeplas, A. M. F., Van de Walle, S., Vandergoten, P., Vanhauwaert, B. G., Vanneste, L., Vercammen, J., Verleyen, D., Vermander, D., Vervoort, G., Weytjens, C., Yanni, N., da Costa Pereira, A., Rocha de Lorenzo, A., Felice Castro Issa, A., Mahler Mioto, B., de Brito Vianna, C., Segre, C. A. W., Grupi, C. J., Okawabata, C., Favarato, D., Giusti Rossi, E., Fernandes, F., Pitella, F., Alvarez Ramires, F. J., Henpin Yue Cesena, F., Monteiro Ferreira, J. F., Junior, J. F., Tonet, L., Nastari, L., Machado Cesar, L., Gowdak, L. H., Matos, M. A., Moretti, M., Morgado, P. C., Vicente Amato, R., Tadeu Munhoz, R., Coimbra, S. R., Luqman, H. N., Yakovova, S., Mantcheva, M., Mincheva, V., Baurenski, L., Karastanev, K., Yordanova, V., Peneva, Y., Bailey, A., Wong, P., Fagan, M., Sabe-Affaki, G., Villasenor, F. M., Belisle, P., Son, W. K., Manyari, D. E., Giacomantonio, N., Lubelsky, B. J., Ezekiel, D., Leong, J. C. S., Grover, A., Vavougios, J., Pesant, Y., Kushner, A. M., Yeung, M. M. M., Vertes, G. E., Nasser-Sharif, F. J., Abdulla, A. H. K., Spensieri, D., Roy, A., Nguyen, T. T., Leclair, M., Morra, P., Everton Biglow, C., Baril, J. F., Lai, K., Wong, D. S., Martinho, V., Antoniadis, G. A., Searles, G. R., Rouse, D., Brisson, G., King Wong, S., Collette, R. S., M. S. C., Ho, Constance, C., Gendreau, R., Kellam, G. W., Cieza Lara, T. A., Boyrazian, H. A., Shamsuzzaman, M., Spink, D. R., Wong, A. P. T., Grewal, R. S., Che, C., Janes, J., Hechtenthal, N., Czarnecka, M., Saulnier, D., Levesque, G., Clavette, P. F., Kennedy, D. R., Kokis, A., Orenstein-Lyall, T. L., Shekhar Pandey, A., Robb, J., Verret, G., Czarnecki, W., Tsui, W. W. H., Perreault, F., Chouinard, G., Lafrance, G., Fullerton, G. M., Lavoie, J. P., Le Bouthillier, P., Tran, Q. H., Rodriguez Marrero, I., Ramadan, F. B., Talbot, P., Fazil, M. A., Cha, J. Y. -M., Garg, S., Chehayeb, R., Roy, B., Chan, Y. K., Harlos, H. E., Matheson, H. B., Patel, R., Vaz, G. F., Bhatt, J. S., Liu, E., Ashton, T. H., Sullivan, H., Quinn, L. P., Yared, K., Gupta, A., Sullivan, B., Campbell, J., Pallie, S., Kim, H., Vizel, S., Savard, D., Cherry, J. M., Gold, J., Chiu, S., Brouillette, G., Singh, R. R., Varma, S., Belanger, A., Myburgh, J. L., Berlingieri, J., Nisker, W., Boutros, G., Bakbak, A. I., Healley, W., Lasalle, L., Liu, F., Tu, C., Lv, S., Liu, X., Gao, H., Li, H., Zhao, H., Cao, L., Zhao, S., Wang, Y., Wu, D., Gu, F., Pan, G., Liu, P., Wang, X., Jiang, H., Li, J., Wang, J., Zhang, L., Ke, Y., Li, D., Chen, G., Xue, H., Jin, Q., Dong, W., Chen, Y., Fu, Z., Hu, H., Liang, Q., Yang, X., Zhou, Z., Xu, Z., Shao, C., Zhang, H., Pei, H., Song, L., Yu, M., Guan, T., Tang, Y., Wu, Y., Yang, M., Ceng, Q., Chen, X., Lin, L., Peng, Y., Yan, X., Yao, E., Zheng, X., Chen, B., Chen, H., Chen, W., Wang, R., Zheng, Y., Tan, H., Zhou, S., Zhou, Y., Liu, Z., Lu, Q., Lai, L., Pan, J., Wang, L., Fu, Q., Peng, J., Du, N., Lv, Y., Miao, W., Wang, H., Pu, Y., Wang, T., Dong, M., Gong, L., Zhang, J., Chen, Z., Jiang, Q., Ma, F., Xu, W., Dai, M., Wu, J., Yu, X., Chen, C., Huo, Y., Sun, L., Gao, W., Li, Z., Hu, Y., Chen, M., Li, G., Xue, M., Yao, Y., Pan, X., Sang, Z., Zhao, G., Hang, J., Ma, S., Zhang, G., Zhou, G., Li, W., Zhu, B., Yu, B., Zhu, S., Mao, J., Xu, M., Liu, Q., Huang, Q., Xie, Y., Feng, L., Chen, F., Chen, L., Liu, Y., Pei, X., Sun, A., Tian, Z., Wang, W., Yang, H., Yu, A., Zhang, M., Zhang, C., Guan, X., Zhou, X., Li, Y., Xing, Y., Chen, K., Luo, L., Dong, S., Zhang, Y., Ai, F., Xiong, C., Yang, F., Yang, K., Yan, J., Zhu, M., Zhang, A., Shan, G., Chen, J., Guo, J., Wu, S., Li, L., Liu, R., Yang, Y., Gao, X., Du, Z., Liang, L., Zhao, Y., Qian, J., He, L., Xiong, L., Chen, P., Peng, C., Zhu, J., Liu, J., Xie, X., Jiang, F., Li, A., Yang, Q., Cong, H., Guo, Y., Ren, N., Xiao, J., Zhao, R., Jiang, J., Deng, X., Wang, S., Wu, K., Zhang, X., Du, W., Shuang, D., Wei, J., Yuan, C., Li, F., Ou, X., Ou, Y., Yu, G., Zhang, S., Gao, J., Qian, Z., Wu, G., Zheng, S., Xu, D., Xie, J., Ren, W., Yao, X., Cai, B., Lv, J., Dong, J., Deng, Z., Bozkova, J., Carda, J., Dedkova, S., Dufka, A., Fridrich, J., Hodac, T., Jirmar, R., Kadleckova, A., Karlicek, M., Krupicka, J., Kuchar, J., Lavicka, V., Leso, J., Lorenc, Z., Micko, M., Navratil, P., Petrova, I., Povolna, P., Raisova, L., Raska, P., Ravlyk, V., Schlesingerova, S., Smrckova, E., Sternthal, P., Stursova, H., Vymetal, P., Zaoral, L., Wiggers, P., Markenvard, J., Andersen, L. K., Frost, L., Refsgaard, J., Strange, S., Egstrup, K., Sykulski, R., Hildebrant, P., Haghfelt, T., Ege, M., Cattan, S., Adam-Blanpain, M., Adda, M., Aimouch, N., Ardouin, L., Assouline, S., Aumjaud, A., Barjhoux, C., Baroudi, R., Beaurain, C., Bennouna, M. A., Bernard, A., Bernardeau, C., Blanc, E., Blum-Decary, I., Bodur, G., Boesch, C., Bonal, J., Bonhomme, R., Bonnet, J. L., Bories, J., Bourachot, M. L., Brumelot, F., Brunehaut Petaut, M., Brunschwig, C., Buffet, P., Calmettes, P., Centa, I., Chartier, B., Chemin, P., Chometon, F., Cohen, J., Colin, R., Cottin, Y., Crespo, F., Dabboura, A., David, F., Dehayes, P., Dematteo, P., Dibon, O., Dodemant, P., Dormagen, V., Dreyfus, X., Dubois, J. M., Duclos, F., Ducoudre, M., Duprez, O., Durand, P., Durand, E., Egloff, P., Escande, M., Escourrou Berdou, M. C., Esna Ashari, G., Feldmann, I., Ferrieres, J., Foltzer, E., Fontanet, B., Garandeau, M., Garban, T., Geffroy, S., Gillet, T., Godart, S., Gosse, P., Gratia, P., Greiner, O., Gueusquin, A., Guiu, E., Guy, J. M., Haddad, S., Hennebelle, V., Honorat, S., Hourany, A., Hua, G., Jacquier, P., Jean, S., Jeremiasz, R., Kohler, P., Lacroix, A., Leandri, M., Lemiere, Y., Liautard, M., Loheac, P., Louchart, J. C., Magnus, P., Maheu, B., Malaterre, H. R., Manchet, G., Mantoux, J., Manzi, D., Marachli, M., Maroun, M., Meneveau, N., Messas, E., Mougeolle, J. L., Mouhat, T., Muller, J. J., Naisseh, M., Nocon, P., Onger, D., Ouguoujil, A., Ovize, M., Page, E., Pareathumby, K., Pleskof, A., Poinson, P., Pons, G., Pouderou, P., Poujois, J. N., Probst, V., Prunier, F., Prunier, L., Puel, V., Rechtman, D., Rennert, R., Rijavec, B., Riou, Y., Robert, J., Roche, C., Roul, G., Salaun, B., Saleh, B., Sandalian, A., Sander, M., Schenowitz, A., Silvestre, A., Soleille, H., Tabet, S., Tardy, M., Thomas-Richard, F., Truong, B., Varaldi, J., Vial, H., Walch, J. M., Wazana, M., Zeitouni, R., Audibert, H., Alizon, F., Amlaiky, A., Asplanato, M., Baranes, C., Bariaud, M., Bernasconi, F., Bousquet, P., Ceraulo, C., De Geeter, G., Donetti, J., Doucet, B., Doucet, J., Dutoya, T., Ennouchi, D., Fallacher, M. H., Fouquet, G., Fourchard, V., Gdalia, J., Grollier, G., Guerard, S., Jeannerat, P. A., Jobic, Y., Joulie, V., Jourdain, P., Jouve, V., Ketelers, R., Khaznadar, G., Kohan, P., Koujan, B., Lammens, B., Landragin, I., Le Moal, E., M'Bey, D., Maes, F., Maheas Morlet, S., Massabie, R., Meddah, D., Meriaux, F. X., Mestre-Fernandes, C., Meyssonnier, P., Migliore, M., Milewski, J., Millet, J. F., Mingam, S., Nazeyrollas, P., Paganelli, F., Pellerin, F., Petitjean, F., Pinzani, A., Pladys, A., Primot, P., Pucheu, A., Rahali, A., Ravoala, P., Rousson, D., Samama, P., Sardon, M., Silvestri, R., Soskin, P., Tabone, X., Tricot, C., Vaquette, B., Vogel, M., Weingrod, M., Aboyans, V., Amoretti, R., Aubry, J., Berthezene, P., Binet, D., Bonnaud, X., Bonnet, P., Bonny, A., Bouchaya, T., Boureux, C., Bourgeois, J. M., Brottier, L., Cavert, B., Cleron, S., Dechoux, E., Delhomme, C., Detienne, J. P., Dubs, J. P., Faudon, B., Fellous, F., Fressonnet, R., Garaud, Y., Garcia, D., Geneves, M., Gleizes, J. L., Guyetand, C., Hermellin, B., Iovescu, D., Kanner, J. P., Khanoyan, P., Leherissier, A., Maximovitch, A., Merian, B., Messali, P., Moreau, Y., Moyal, J., Payot, L., Petoin Peuch, L., Prevot, J. L., Raymond, P., Relange, D., Reymond, S., Robert, J. F., Rosenstein, H., Schneider, J., Schultz, R., Tanielian, P., Thoin, F., Thomas, L., Touzet, P., Steg, G., Amiel Oster Sauvinet, G., Baylac Domengetroy, F., Chamou, K., Etcheverry, B., Farges, J. L., Fraboulet, J. Y., Goralski, M., Janody, D., Mamez, B., Manlay, W., Paillard, F., Pelier, F., Petit, A., Skonieczny, M., Augarde, R., Fournier, J. B., Liandrat, S., Lim, P., Noury, A. I., Paris, D., Saade, M., Stordeur, J. M., Pornin, M., Galinier, M., Balice-Pasquinelli, M. A., Sosner, P., Yvorra, S., Delcoulx, E., Mouquet, F., Poulard, J. E., Sudre, A., Heno, P., Biausque, F., Guenoun, M., Attia, G., Pouwels, S., Carpentier, L., Verbrugge, E., Ziccarelli, C., Elkohen, M., Tricoire, J., Lang, P., Huttin, O., Altevogt, B. -M., Altmann, U., Baar, M., Berrisch-Rahmel, S., Birkenhagen, A., Blase, I., Blindt, R., Bosch, R., Brattstrom, A., Breuer, H. -H., Castrucci, M., Cicek-Hartvig, S., Cierpka, R., Claus, M., Deissner, M., Drexler, M., Eggeling, T., Eisele, G., Enayat, D., Frickel, S., Gessner, S., Giokoglu, K., Gmehling, J., Goss, F., Grooterhorst, P., Gysan, D. B., Haberl, R., Haerer, W., Hassler jun, N., Heinemann, S., Henschel, F., Hinrichsen, M., Hofer, W., Hofmeister, A., Hoh, G., Horstkotte, E., Jager, F., Jeserich, M., Keil, U., Killat, H., Kimmel, S., Kindel, M., Kindler, P., Kleta, S., Konemann, J., Konig, K., Krause-Allmendinger, H., Kronberg, K., Kruck, I., Mannl, V., Meinel, A., Mentz, G., Meyer-Michael, E., Mibach, F., Moller, S., Muth, S., Nelbock-Huber, E., Ohlmeyer, D., Ozkan-Rashed, Z., Paulus, C. -P., Perings, S., Placke, J., Raters, C., Reifart, N., Rink, A., Rybak, K., Salecker, I., Schermaul, K. -H., Schmidt, E., Schmitz, K. -H., Schon, N., Schroder, T., Sievers, B., Simon, M., Spengler, U., Speth-Nitschke, M., Stumpp, A., Szabo, S., Taggeselle, J., Tamm, A., Thelemann, A., Thelemann, C., Thummel, H., Unger, G., Utech, A., Volmar, J., Wauer, B., Wehr, G., Weinrich, L., Weinrich, R., Windstetter, U., Wirtz, J. H., Wittlich, N., Ziehn, P., Zundorf, P., Al Wahshi, Y., Singh, P. P., Narayan, A., Al Tamimi, F., Al Yazeedi, J., Ayche, M., Al Lawati, A., Al Dhanki, M., Salustri, A., Al Sousi, A., Salah, T., Tamimi, M. Y., Agrawal, A., Wassef, A., Baslaib, F., Al Radaideh, G., Yusufali, A., Bazargani, N., Akbar, M., Abdel Wahab, H., Abdel Malak, S., Ghaly, I., Al Ghool, S., Al Kandari, F., Haiba, M., Alanbaei, M., El Menyar, A., Gomaa, M. 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J., Pinero Ramirez, C., Porras Ramos, Y., Ramos Ariznabarreta, F., Rayo Gutierrez, M., Roca Catalan, J. M., Rodriguez Almodovar, A., Rodriguez Collado, J., Rodriguez Fernandez, A., Rodriguez Fernandez, J. A., Rodriguez Hernandez, J. A., Rodriguez Tejero, I., Romeo Castillejo, I., Romero Alvira, D., Romero Hinojosa, J. A., Romero Menor, C., Rossi Sevillano, P., Rueda Calle, E. C., Rueda Soriano, J., Ruiz Perez, P., Sagastagoitia Gorostiza, T., Sainz Hidalgo, I., Sandin Rollan, M., Santaolalla Rodriguez, S., Santas Olmeda, E., Santos Iglesias, J. L., Sanz Rodriguez, M. L., Segura Laborda, I., Serrano Garcia, S., Sevilla Toral, B., Silva Melchor, L., Simarro Martin-Ambrioso, E., Sola Casado, R., Soriano Navarro, C., Soto Ruiz, M. I., Talavera Calle, P., Torres Diaz, P. L., Troncoso Gil, A., Trujillo Berraquero, F., Ulecia Martinez, M. A., Umaran Sanchez, J., Vaticon Herreros, C., Vazquez Garcia, A., Vega Barbado, J. L., Velasco Espejo-Saavedra, E., Vicente Vera, T., Vida Gutierrez, M., Villar Mariscal, C., Vives Bonato, G., Wu Amen, L., Yanes Bowden, G., Yanez Wonenburger, J. C., Zamorano Gomez, J. L., Zarauza Navarro, J., Monnier, P., Forclaz, A., Grobety, M., Schlueter, L., Vuille, C., Nacht, C. A., Evequoz, D., Ciaroni, S., Domine, F., Berube, J., Hellermann, J., Koller, R., Bourgeois, G., Engel, R., Niederberger, C., Stadler, P., Gnadinger, M., Schmied, C., Wettstein, T., Badorff, C., Hilti, P., Chetelat, C. A., Sepulcri, F., Brunner, H., Schindler, J., Kraus, M., Gmur, W., Bouranasompop, C., Jiraroj-ungkun, W., Lapanun, W., Vivekaphirat, V., Panpunnung, S., Dutsadeevettakul, S., Tasneeyapant, S., Ngamjanyaporn, P., Apitamsuntorn, S., Tantisiriwat, W., Suithichaiyakul, T., Kuanprasert, S., Wongcharoen, W., Phrommintikul, A., Musigchai, C., Chantrarat, T., Uerojanaungkul, P., Apinyasawat, S., Tangcharoen, T., Lertnantakul, M., Wasuwat, A., Harinasuta, J., See, O., Chaithiraphan, V., Boonyasirinant, T., Boonyapisit, W., Kittipovanonth, M., Buakhamsri, A., Piyayotai, D., Hutayanon, P., Junejo, S., Aiyegbayo, O., Ancliff, H., Bradshaw, C., Cervenak, R., Choi, H., George, E., Gilmour, I., Gough, D., Idrissi-Sbai, A., Ingham, J., Al-Khalidi, B., Liston, A., Mackrell, J., Pattison, I., Ramachandran, R., Ray, N., Reddy, G., Sen, I., Shetty, K., Singh, L., Stanley, M., Wallace, A., Weatherhead, M., Gilbert, T., McCansh, G., Higgins, S., Killeen, C., Cromarty, I., Franklin, P., Pinch, E., Dhesi, A., Dernedde, C., Lawrence, M., Simper, H., Noble, M., Dalton, G., Stevens, L., Berry, P., Hand, C., Oliver, R., Jones, H., Sampson, P., Taylor, N., Grogono, R., Dalrymple, J., Martin, A., Thurston, S., Elsby, K., Vallis, M., Morrison, G., Lang, C., Watson, A., Thomson, A., Dougall, H., La Hay, B., Compson, L., McCracken, A., Calder, J., Weber, F., Richmond, D., Brownlie, R., Brown, G., MacCowan, H., Heap, A., Perry, M., Holden, L. A., Scott, G., Haldane, N., Hood, S., Cullen, I., Bell, J., McNaught, P., Sharif, M., Dunn, J., Hay, D., Ross, S., Shaw, R., Hay, L., Langridge, S., Burns, R., Crawford, L., Kennedy, A., Logan, D., McAlavey, P., Brown, M., Costello, P., McLaren, G., Potter, A., McPherson, J., Drijfhout, M., Finlayson, J., Troup, D., Woodall, A., Pearce, J., Williams, S., Parkar, W., Yusuf, A., Benett, I., Bishop, P., Thomas, H., Caldwell, I., Ormiston, P., Kwok, S., Kanumilli, N., Saul, P., Milligan, H., Wilkinson, I., Vance, A., Paul, N., Paul, C., Shaikh, I., Ellis, R., Vites, N., Steeds, R., Goodwin, D., Aftab, A., Banham, S., Chauhan, N., Grocutt, M. S., Gupte, A., Jordan, R., Jheeta, B. S., Ladha, K., Nazir, M., Pal, R., Patel, R. P., McManus, R., Singal, A., Saunders, P., Syed, A. B., Bahal, A., Dau, H., Walker, D. M., McNeilly, R., Bolidai, A., MacCarthy, N., Lawton, D., Vardhani, M., Sengupta, G., Kinloch, D., Howie, F., Serrano-Garcia, A., Paget, S. E., Till, R., Seal, P., Morrell, J., Maxwell, T., Singh, G., Warden, D., Elias, R., Dixon, C., Pandey, R. K., Challenor, V., Davies, S., Gibbs, M., Gillet, A., Goldie, C., Jarvis, I., Johnson, P., Malden, M., Moore, J., Morton, C., Nehrig, K., Sheringham, P., Wilson, G., Halcox, J., O'Connor, I., Ling, K., Edwards, D., Charles, H., Weatherup, A., Davies, E., Watkins, N., Morgan, D., Davies, R., Lindsay, A., Beacock, D., Balai, R., Kirmond, P., Brindle, P., Bundy, C., Cahill, T., Dayani, A., Eavis, P., Mohr, S., Hayne, S., Krasucki, C., Micheals, M., Orpen, I., Parker, I., Sewell, R., Sharp, D., Smith, A., Stevens, A., Upton, J., Victory, J., Wernham, C., Davis, R., Mays, C., Andrews, M., Takhar, J., Travill, C., Choudhury, P., Matta, W., Ihonor, A., O'Dong, C., Rahman, S., Singer, P., Gillam, S., Bath, P. S., Razzaq, N., O'Toole, O., Rowe, P., Williams, H., Allcock, A., Tucker, A., Sprott, V., Kyd, K., Cunliffe, G., Arden, C., Bateman, A., Kassianos, G., Sinclair, D., Turner, C., Jagathesan, R., Sattar, F., Ashford, A., Chukwu, A., Taylor, H., Pradhan, R., Rundell, T., Howlett, R., Bietzk, R., Myint, M., Partington, M., O'Reilly, F., Baverstock, M., Dixon, S., Tennekoon, M., Brand, N., Haimes, P., Keller, P., Whetstone, S., Kovyrshyna, O., Rogozhyna, V., Kiver, T., Vasylenko, V., Kucheryava, L., Salimova, S., Alekseenko, V., Gukov, O., Myhailiv, I., Kardashevskaya, L., Prikolota, O., Bashkirtcev, O., Andreev, E., Tkachenko, L., Mospan, M., Batushkin, V., Safonova, L., Ogorodnichuk, A., Pustovit, S., Romanov, S., Burlakova, L., Voloshko, Y., Lafarenko, V., Vlasuk, Z., Leshchuk, O., Chushak, S., Koval, V., Stasuk, O., Pogrebna, O., Kornienko, S., Tikhonova, S., Fesenko, T., Kuzmina, T., Ushakov, O., Vechtomova, N., Potapska, L., Illushechkin, I., Kryvenkova, E., Lysunets, O., Tsygankov, O., Bardachenko, L., Voloshyna, L., Ginzburg, V., Franskyavichene, L., Korotich, T., Vyshnevaya, N., Bilous, N., Kulinich, S., Kulik, V., Sadykova, I., Berezhna, T., Molotyagina, S., Pham, M. H., Pham, H. T., Khong, N. H., K. B., Do, T. B., Le, P. A., Do, T. C., Do, Nguyen, N. Q., Q. H., Do, K. C., Vu, Pham, N. H., Pham, T. H. T., M. C., Ta, Phan, D. P., Nguyen, T. T. H., Pham, T. T. N., T. L., To, V. T., Le, Dang, L., Bui, L., Pham, T. T. H., Phan, H. H., Bui, T. T. H., Tuong, T. V. A., Nguyen, T. P., Nguyen, T. H., Nguyen, B. K., D. B., Vu, Pham, N. S., T. Q., Do, Pham, T. S., Dang, V. D., D. T., Le, V. C., Do, Nguyen, T. K. L., Luong, H. D., Luu, T. Q., Pham, N. V., Huynh, T. K., N. T. H., Tu, Ngo, K. A., Nguyen, T. T. C., Ong, T. T. L., Doan, V. B., Kim, T. B., T. N., Vo, Tran, T. T. T., Nguyen, T. A., Tran, V. D., Nguyen, A. K., Tran, A. C., Ngo, M. H., N. H., Vu, I. T., Ly, Tran, N. P. H., Tran, L. U. P., Nguyen, T. N., Tran, T. H., Truong, P. H., Mai, T. L., Hoang, V. S., Bui, C. M. A., Dang, V. P., Truong, Q. B., M. P., Vo, Nguyen, V. T., Chau, N. H., T. T. H., Ta, Dinh, H. N., Tran, H., Nguyen, H. K. N., Chung, A., Chung, E., Martina-Hooi, B., Angela, R., Ramoutar, P., Fillet, R., Tilluckdharry, R., Dookie, T., Foster, E., Hart, C., Omardeen, F., Ramphall, S., Lalla, C., Cheng, J., Elliott, V., Falconer, H., Hurlock-Clarke, L., Ishmael, R., Lalljie, G., Lee, K., Liqui-Lung, A., Massay, R., Mohammed, H., Brown, C., Daniel, R., Didier, M., Salas, Z., CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), University of Glasgow, Maria Cecilia Hospital [Cotignola], Royal Brompton Hospital, Montreal Heart Institute Coordinating Centre (MHICC), Université de Montréal (UdeM), Medical University of Silesia (SUM), Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Dorogoichenko, Aleksandra, Laucevičius, Aleksandras, Jurgaitienė, Rūta, Šlapikas, Rimvydas, Barauskienė, Gražina, Jankauskienė, Edita, Revienė, Sigita, Vaišvila, Tautvydas, Zaronskienė, Danutė, Šlapikienė, Ona Birutė, Kupstytė, Nora, Rinkūnienė, Egidija, Steponėnienė, Rima Vitalija, Kojelienė, Jūratė, Badarienė, Jolita, Dženkevičiūtė, Vilma, Sadauskienė, Eglė, Butkuvienė, Irena, Stankevičius, R., Paliulionienė, R., Snikytė, R., Mažutavičius, R., and CLARIFY Investigators
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Male ,Genetics and Molecular Biology (all) ,Heart disease ,medicine.medical_treatment ,atrial fibrillation ,coronary ,anticoagulants ,patients ,atrial flutter ,lcsh:Medicine ,Coronary Artery Disease ,Practice Patterns ,030204 cardiovascular system & hematology ,Chest pain ,Biochemistry ,[SHS]Humanities and Social Sciences ,Cohort Studies ,Coronary artery disease ,Angina ,0302 clinical medicine ,Aged ,Anticoagulants ,Atrial Fibrillation ,Drug Therapy, Combination ,Female ,Guideline Adherence ,Humans ,Outpatients ,Platelet Aggregation Inhibitors ,Practice Patterns, Physicians' ,Registries ,Practice Patterns, Physicians'/statistics & numerical data ,030212 general & internal medicine ,Myocardial infarction ,lcsh:Science ,Stroke ,Anticoagulants/administration & dosage ,Multidisciplinary ,Medicine (all) ,Atrial fibrillation ,Guideline Adherence/statistics & numerical data ,3. Good health ,Combination ,Cardiology ,[SHS] Humanities and Social Sciences ,medicine.symptom ,Research Article ,medicine.medical_specialty ,Coronary Artery Disease/drug therapy ,Agricultural and Biological Sciences (all) ,Biochemistry, Genetics and Molecular Biology (all) ,NO ,03 medical and health sciences ,Drug Therapy ,Internal medicine ,medicine ,Platelet Aggregation Inhibitors/administration & dosage ,Physicians' ,Atrial Fibrillation/drug therapy ,business.industry ,lcsh:R ,Percutaneous coronary intervention ,Outpatients/statistics & numerical data ,medicine.disease ,lcsh:Q ,Human medicine ,business - Abstract
BACKGROUND: Few data are available regarding the use of antithrombotic strategies in coronary artery disease patients with atrial fibrillation (AF) in everyday practice. We sought to describe the prevalence of AF and its antithrombotic management in a contemporary population of patients with stable coronary artery disease.METHODS AND FINDINGS: CLARIFY is an international, prospective, longitudinal registry of outpatients with stable coronary artery disease, defined as prior (≥12 months) myocardial infarction, revascularization procedure, coronary stenosis >50%, or chest pain associated with evidence of myocardial ischemia. Overall, 33,428 patients were screened, of whom 32,954 had data available for analysis at baseline; of these 2,229 (6.7%) had a history of AF. Median (interquartile range) CHA2DS2-VASc score was 4 (3, 5). Oral anticoagulation alone was used in 25.7%, antiplatelet therapy alone in 52.8% (single 41.8%, dual 11.0%), and both in 21.5%. OAC use was independently associated with permanent AF (pCONCLUSIONS: In this contemporary cohort of patients with stable coronary artery disease and AF, most of whom are theoretical candidates for anticoagulation, oral anticoagulants were used in only 47.2%. Half of the patients received antiplatelet therapy alone and one-fifth received both antiplatelets and oral anticoagulants. Efforts are needed to improve adherence to guidelines in these patients.TRIAL REGISTRATION: ISRCTN registry of clinical trials: ISRCTN43070564.
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- 2015
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13. PCN71 - BUDGET IMPACT ANALYSIS OF INOTUZUMAB OZOGAMICIN FOR THE TREATMENT OF ADULTS WITH RELAPSED OR REFRACTORY B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA IN BULGARIA
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Djambazov, S., Slavchev, G., Encheva-Malinova, M., Pavlova, Y., Varbanova, V., Velchev, M., and Vekov, T.
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- 2018
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14. Assessing adaptive management options to cope with climate change at the farm level
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Rötter, R.P., Lehtonen, H., Kahiluoto, J., Helin, J., Palosuo, T., Salo, T., Pavlova, Y., Wolf, J., Carter, T.R., and Ewert, F.
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climatic change ,bedrijfssystemen ,landbouw ,klimaatadaptatie ,Soil Science Centre ,climate adaptation ,farming systems ,Alterra - Centrum Bodem ,klimaatverandering ,Wageningen Environmental Research ,PE&RC ,agriculture - Abstract
In recent years, considerable achievements have been made by several European climate research groups in gaining a better understanding of and in developing methodologies and tools for integrated, multiscale analyses of how to adapt agricultural systems to climate change. Efforts are under way to link these advancements with the CGIAR-led program on “Climate Change, Agriculture, and Food Security” (CCAFS) for the developing world. In this context some methodological advancements and findings are presented from Finnish and European collaborative research on integrated assessment and modeling (IAM) of agrifood systems in the context of climate change.
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- 2010
15. Business-as-usual, High Technology and Coalition Scenarios for Transboundary Pollution in the European Union
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Pavlova, Y.
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The paper addresses the issue of air pollution in the European Union (EU). The focus is on economic and environmental assessment of alternative pollution control scenarios. In order to derive policy-relevant conclusions, we develop an ecology-economy model of the EU by linking an environmental effect from countries' SO2 (sulphur dioxide) abatement with their economic outcomes. We consider SO2 reduction strategies (GAINS) available for the EU member states during 2015-2020 and, compare environmental and economic impacts in two scenarios assuming that a base-line abatement technology and respectively, an advanced abatement technology are being used. Furthermore, we introduce elements of game theory and consider a possibility for cooperation in air pollution abatement among several Baltic countries (Finland, Sweden, Denmark and Latvia). The optimal choice of the technologies and corresponding levels of SO2 reduction are determined for the given countries. The coalition scenario is shown to be superior to the baseline scenario. We study a positive externality effect and demonstrate that the neighboring countries, Estonia and Lithuania, receive the highest impact from pollution reduction. Possible free-riding by Latvia and Finland is considered. It has been proven that stability of cooperation is achievable.
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- 2009
16. Biochar made from chicken manure - a fertilizer that can ensure the carbon neutrality of agricultural soils in conditions of elevated temperatures
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Kuryntseva Polina, Galieva Gulnaz, Pavlova Yuliya, Galitskaya Polina, and Selivanovskaya Svetlana
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Environmental sciences ,GE1-350 - Abstract
Amendment of soil with biochar instead of mineral or organic fertilizers might be one of techniques wich reduce carbon dioxide emissions into the atmosphere. The effect of biochar based on chicken manure on the biomass and respiratory activity of agricultural soil microorganisms was evaluated in lab conditions at normal (average climatic norm for the vegetation season in central Russia, 15 °C) and elevated (25 and 35 °C) temperatures. It was shown that the introduction of 10% biochar by mass did not lead to an increase emission of CO2 from the soil relative to the control at 15 °C for 60 days of the experiment. An increase in temperature caused an increase in carbon dioxide emissions from the control soil by 35% and 91% and a decrease in moisture by 24% and 42% at 25 and 35°C, respectively. Microbial biomass increased in the control soil by 32% at 25°C and decreased by 34% at 35°C. Soil amendment with biochar led to the leveling of the effect of elevated temperatures on all three parameters. Thus, biochar made from chicken manure allowed one of the characteristics of soil fertility to be preserved and did not lead to the loss of greenhouse gases.
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- 2023
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17. Electronic Spectra of Porous Silicon near Fermi Level
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Aprelev, A. M., Lisachenko, A. A., Laiho, R., Pavlov, A., and Pavlova, Y.
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Condensed Matter (cond-mat) ,technology, industry, and agriculture ,FOS: Physical sciences ,Condensed Matter ,Physics::Geophysics - Abstract
Electronic spectra of porous Si have been investigated in the region $, Comment: 7 pages, LaTeX, 3 PostScript figures. Also available at ftp://phot2.niif.spb.su
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- 1996
18. Economic and environmental approach to agricultural and rural development
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Pavlova Yulia
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Microbiology ,QR1-502 ,Physiology ,QP1-981 ,Zoology ,QL1-991 - Abstract
This article discusses the choice of a model for development of agriculture and, accordingly, rural areas, taking into account the economic and environmental approach. The main producers of agricultural products and users of land resources are not only large and small agricultural organizations, but also personal subsidiary plots. The efficiency of use of land resources by households is much higher than in other agricultural organizations. Personal subsidiary plots in production of agricultural products use resource-saving technologies. Today, personal subsidiary plots remain without due attention from the state, business and the scientific community. They are also deprived of economic, financial, informational, technological, and human resources. As a practical implementation of theoretical conclusions, the article offers the implementation of the Bioekopolis project. In the territory of the Kanashsky district of the Chuvash Republic on the basis of Atalanu LLC from 2016 to 2021. experimental work was carried out to create individual elements of a small-scale rural settlement based on the principles of bioecopolis. The results of scientific and experimental design work, the experience of operating a residential building and outbuildings, the established operating mode of innovation gave the basis for development of an innovative project and the opportunity for its subsequent replication.
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- 2022
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19. Evaluation results of stud bulls by offspring quality
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Gorelik O.V., Galyshina P.S., Smirnova E.S., Pavlova Ya.S., and Bezhinar T.I.
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Microbiology ,QR1-502 ,Physiology ,QP1-981 ,Zoology ,QL1-991 - Abstract
Purebred stud bulls of a related Holstein breed are widely used when breeding domestic black-and-white cattle breeds. Results’ evaluation of using these stud bulls by offspring quality is relevant and has practical significance. Stud bulls of the Vis Back Ideal 1013415 line were evaluated in one of the breeding farms of the Moscow region. As a result, it was found that all the evaluated stud bulls had a high breeding value. Bulls Trubach 174 - A1; Nog Odin-M 490626 - A1; Lowlands-M 427373367 – A2 were assigned categories by milk yield, bulls Memory-M 54215651 – B2; Fern-M 107901925 - B1; Lowlands-M 427373367 – B1. The evaluation of nutrients’ yield with milk showed that when using the offspring of Memory-M 54215651 bull, negative results were obtained despite that it has a category B2. According to the nutrients’ yield with milk. Thus, stud bulls of the Vis Back Ideal 1013415 line: Trubach 174; Nog Odin-M 490626; Memory-M 54215651; Fern-M 107901925; Lowlands-M 427373367 can be used on the farm considering their breeding value. Lowlands-M 427373367 bull with category A2 B1 requires wider use.
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- 2022
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20. Productivity of Holsteinized black-and-white cattle depending on age
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Neverova O.P., Harlap S.Yu., Pavlova Ya.S., Neverova E.P., and Alexandrina E.V.
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Microbiology ,QR1-502 ,Physiology ,QP1-981 ,Zoology ,QL1-991 - Abstract
The Ural type of the domestic black-and-white breed is characterized by high productivity and good suitability for use in the conditions of industrial milk technology. During its breeding, the use of purebred bulls-producers of the Holstein breed of both domestic and foreign breeding continues. As a result of the conducted research, it was found that the productivity of cows changes significantly with age. Milk yield for 305 days of lactation increases from 1 lactation to 3 lactation, and then decreases by 369 kg or 3.8% in the fourth, relative to the third, and by 2090 kg or 22.2% in the fifth, relative to the fourth. The productivity of full-aged cows is higher than that of young cows and can remain at a high level for a long period. The quality indicators of milk changed upward from the first to the fifth lactation. High correlation coefficients were established by the conjugation of milk quality indicators with each other, regardless of lactation. They ranged from 0.364 (2 lactation) to 0.533 (1 lactation). That is, a decrease or increase in MJ in milk will lead to the same change in MDB.
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- 2022
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21. Formation and dynamics of Saturn and its disk simulated by using a new N-body model.
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Pavlov, A. and Pavlova, Y.
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The formation of Saturn and its disk is simulated using a new N-body self-gravitational model. It is demonstrated that the formation of the disk and the planet is the result of gravitational contraction of a slowly rotated particle cloud that have a shape of slightly deformed sphere. The sphere was flattened by a coefficient of 0.8 along the axis of rotation. During the gravitational contraction, the major part of the cloud transformed into a planet and a minor part transformed into a disk. The thin structured disk is a result of the electromagnetic interaction in which the magnetic forces acting on charged particles of the cloud originate in the core of the planet. The simulation program gives such parameters of Saturn as the escape velocity of about 35 km/s at the surface, density, rotational velocities of the rings and temperature distribution. [ABSTRACT FROM AUTHOR]
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- 2003
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22. Evolution of Elliptical Galaxies and Mechanism of Formation of Spiral Galaxies.
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Pavlov, A. and Pavlova, Y.
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- *
ELLIPTICAL galaxies , *ROTATIONAL motion (Rigid dynamics) , *CELESTIAL mechanics - Abstract
A mechanism of formation of a spiral galaxy is proposed. The galaxy is considered to be a cluster consisting of stars and gaseous clouds. Initially, the galaxy has elliptical geometry and slow rotational motion around one axis. The gravitational interaction between the stars has been modelled. The cluster contracted and transformed its geometry. The geometry of the initial cluster changes due to the change of the rotational velocities of the stars in accordance with the Kepler's second law and change of the relative positions of the stars. The computer simulation reveals that a spiral shaped galaxy is a result of the transformation of a cluster of non-spherical symmetry. An example of the gravitational contraction of an elliptically-shaped galaxy is presented in this paper. [ABSTRACT FROM AUTHOR]
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- 2003
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23. Interaction of economically useful traits in cows of different breeds
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Rebezov M.B., Gorelik А.S., Pavlova Y.S., Khorobrykh E.V., and Sharavyev P.V.
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Environmental sciences ,GE1-350 - Abstract
A related Holstein breed has recently been used to improve domestic dairy cattle and create highly productive herds by purchasing semen from breeding bulls, as well as a large number of heifers and calves of foreign breeding. The purpose of the work is a comparative assessment of the productive qualities of Black Pied and Holstein cows of foreign breeding. Purebred Holstein cows differ from animals of Black Pied breed in milk yield per lactation. Cows of both breeds have fairly high suitability for machine milking. The priority remains with the animals of the Holstein breed of foreign selection. In terms of milking intensity and udder volume, they reliably surpass Black Pied cows at P≤0.05 - P≤0.01, respectively, in terms of indicators. Holstein cows were also the best in the udder index. Correlation coefficients between the productive qualities, as well as between the quantitative indicator of productivity and the qualitative indicators of the suitability of cows for machine milking, were the same or did not differ significantly. A positive correlation was established between milk yield and the duration of the service period from 0.1 to 0.05, depending on the breed.
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- 2021
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24. Sustainable independent tourism: the role of the information and communication technologies
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Sutyrina Olga, Domracheva Svetlana, Okhotina Natalia, and Pavlova Yana
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Environmental sciences ,GE1-350 - Abstract
This paper focuses on the role of information and communication technologies (ICT) in the sustainable independent tourism and hospitality. Moreover, it attempts to identify emerging trends in tourism of the 21st century. Nowadays, tourism has become more independent on large travel agencies and package tours and this transition has been caused by the development of Internet and information technologies. Most recently, the rise of the sharing economy had an array of important implications for the tourism sector with such digital platforms as Uber, Airbnb, Gett, Lyft, TripAdvisor, Expedia or Booking.com replacing the traditional ways to travel. Surely, independent tourism is not for everyone and might be restricted to small groups of people. However, it is crucial for sustainable development in tourism and hospitality sector due to the fact that it can replace massive tourism and limit the extent of overtourism in many popular destinations.
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- 2021
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25. SINGLE DOSE OF RITUXIMAB IN THE TREATMENT OF RESISTANT ACUTE ANTIBODY-MEDIATED REJECTION: A SINGLE DOSE CENTRE EXPERIENCE.
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Slatinska, J., Honsova, E., Burgelova, M., Pavlova, Y., Wohlfahrt, P., and Viklicky, O.
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- 2010
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26. EVALUATION OF SOLUBLE CD30, HEPATOCYTE GROWTH FACTOR AND HLA ANTIBODIES AS MARKERS OF KIDNEY ALLOGRAFT REJECTION.
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Pavlova, Y., Slavcev, A., Burgelova, M., Süsal, C., Slatinska, J., Opelz, G., Striz, I., and Viklicky, O.
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- 2010
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27. CO-CULTURES WITH RESPIRATORY EPITHELIAL CELLS MODULATE CYTOKINE GENE EXPRESSION IN HUMAN MACROPHAGES.
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Kolesar, L., Brabcova, E., Pavlova, Y., Slavcev, A., and Striz, I.
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- 2010
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28. Observation of the photovoltaic and related effects in porous silicon by scanning tunneling microscopy
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Laiho, R, Pavlov, A, and Pavlova, Y
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- 1997
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29. UV ( hν=8.43 eV) photoelectron spectroscopy of porous silicon near Fermi level
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Aprelev, A.M, Lisachenko, A.A, Laiho, R, Pavlov, A, and Pavlova, Y
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- 1997
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30. Investigation of the surface topography of light emitting nanostructures of porous Si and the related photovoltaic effect by photoassisted scanning tunnelling microscopy
- Author
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Pavlov, A and Pavlova, Y
- Published
- 1997
- Full Text
- View/download PDF
31. A novel room temperature oscillatory phenomenon in photoinduced scanning tunnelling microscope spectra of porous Si.
- Author
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Afonin, V. V., Gurevich, V. L., Laiho, R., Pavlov, A., and Pavlova, Y.
- Published
- 1998
- Full Text
- View/download PDF
32. A Precision Engineered Interleukin-2 for Bolstering CD8+ T- and NK-cell Activity without Eosinophilia and Vascular Leak Syndrome in Nonhuman Primates.
- Author
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Ma L, Acuff NV, Joseph IB, Ptacin JL, Caffaro CE, San Jose KM, Aerni HR, Carrio R, Byers AM, Herman RW, Pavlova Y, Pena MJ, Chen DB, Buetz C, Ismaili TK, Pham HV, Cucchetti M, Sassoon I, Koriazova LK, Leveque JA, Shawver LK, Mooney JM, and Milla ME
- Subjects
- Animals, Humans, Capillary Leak Syndrome drug therapy, Eosinophilia drug therapy, Eosinophilia immunology, Macaca mulatta, Male, Female, CD8-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes drug effects, Killer Cells, Natural immunology, Killer Cells, Natural drug effects, Interleukin-2 administration & dosage, Interleukin-2 pharmacology
- Abstract
We have created a precisely pegylated IL-2 [SAR-444245 (SAR'245) or pegenzileukin, previously THOR-707] designed for proliferation of target CD8+ T and NK cells for anticancer activity, with minimal expansion of anti-target regulatory CD4+ T cells (Treg) that counter their action, or eosinophils that trigger vascular leak syndrome (VLS). We performed in vivo studies in nonhuman primates (NHP) to monitor the safety of SAR'245, pharmacokinetic profile, and pharmacodynamic parameters including expansion of peripheral CD8+ T and NK cells, and effects on Tregs and eosinophils. Studies included multiple ascending dosing and repeat dosing with different regimens (QW, Q2W, Q3W and Q4W). We also conducted ex vivo studies using human primary cells to further evaluate SAR'245 stimulation of target cells alone and in combination with programmed cell-death 1 (PD-1) checkpoint inhibitors. The pharmacokinetic profile of SAR'245 in NHP demonstrated dose-proportional exposure that was comparable with redosing. It elicited expansion of peripheral CD8+ T and NK cells that was comparable with each dose and with multiple dosing regimens. Once-weekly dosing showed no significant adverse effects, including no hallmark signs of VLS at dosing levels up to 1 mg/kg. Ex vivo, SAR'245 enhanced T-cell receptor responses alone and in combination with PD-1 inhibitors without inducing cytokines associated with cytokine release syndrome or VLS. Results support the clinical development of SAR'245 as a drug candidate for the treatment of solid tumors, alone or in combination with PD-1 inhibitory agents., Significance: SAR-444245 (SAR'245, pegenzileukin) is an extended half-life IL-2 that targets effector CD8+ T and NK cells, with little effect on regulatory T cells. We show that in the nonhuman primate model that closely approximates human immune function and response to IL-2, SAR'245 selectively activates CD8+ T and NK effectors without significant serious side effects (vascular leak syndrome or cytokine release syndrome), suggesting its potential for the treatment of solid tumors in humans., (©2024 The Authors; Published by the American Association for Cancer Research.)
- Published
- 2024
- Full Text
- View/download PDF
33. A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism.
- Author
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Ptacin JL, Ma L, Caffaro CE, Acuff NV, Germar K, Severy P, Qu Y, Vela JL, Cai X, San Jose KM, Aerni HR, Chen DB, Esche E, Ismaili TK, Herman R, Pavlova Y, Pena MJ, Nguyen J, Koriazova LK, Shawver LK, Joseph IB, Mooney J, Peakman M, and Milla ME
- Abstract
Background: Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK) properties. Recombinant human interleukin-2 (rhIL-2) has shown promise for treatment of autoimmune (AI) disorders yet exhibits short systemic half-life and opposing immune responses that negate an appropriate therapeutic index., Methods: A semi-synthetic microbial technology platform was used to engineer a site-specifically pegylated form of rhIL-2 with enhanced PK, specificity for induction of immune-suppressive regulatory CD4 + T cells (Tregs), and reduced stimulation of off-target effector T and NK cells. A library of rhIL-2 molecules was constructed with single site-specific, biorthogonal chemistry-compatible non-canonical amino acids installed near the interface where IL-2 engages its cognate receptor βγ (IL-2Rβγ) signaling complex. Biorthogonal site-specific pegylation and functional screening identified variants that retained engagement of the IL-2Rα chain with attenuated potency at the IL-2Rβγ complex., Results: Phenotypic screening in mouse identifies SAR444336 (SAR'336; formerly known as THOR-809), rhIL-2 pegylated at H16, as a potential development candidate that specifically expands peripheral CD4+ Tregs with upregulation of markers that correlate with their suppressive function including FoxP3, ICOS and Helios, yet minimally expands CD8 + T or NK cells. In non-human primate, administration of SAR'336 also induces dose-dependent expansion of Tregs and upregulated suppressive markers without significant expansion of CD8 + T or NK cells. SAR'336 administration reduces inflammation in a delayed-type hypersensitivity mouse model, potently suppressing CD4+ and CD8 + T cell proliferation., Conclusion: SAR'336 is a specific Treg activator, supporting its further development for the treatment of AI diseases., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
34. An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.
- Author
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Ptacin JL, Caffaro CE, Ma L, San Jose Gall KM, Aerni HR, Acuff NV, Herman RW, Pavlova Y, Pena MJ, Chen DB, Koriazova LK, Shawver LK, Joseph IB, and Milla ME
- Subjects
- Animals, CD8-Positive T-Lymphocytes drug effects, CD8-Positive T-Lymphocytes immunology, Drug Discovery, Genetic Engineering, Humans, Interleukin-2 genetics, Interleukin-2 Receptor alpha Subunit, Killer Cells, Natural drug effects, Killer Cells, Natural immunology, Lymphocytes drug effects, Mice, Synthetic Biology, Antineoplastic Agents therapeutic use, Interleukin-2 chemistry, Interleukin-2 metabolism, Interleukin-2 pharmacology
- Abstract
The implementation of applied engineering principles to create synthetic biological systems promises to revolutionize medicine, but application of fundamentally redesigned organisms has thus far not impacted practical drug development. Here we utilize an engineered microbial organism with a six-letter semi-synthetic DNA code to generate a library of site-specific, click chemistry compatible amino acid substitutions in the human cytokine IL-2. Targeted covalent modification of IL-2 variants with PEG polymers and screening identifies compounds with distinct IL-2 receptor specificities and improved pharmacological properties. One variant, termed THOR-707, selectively engages the IL-2 receptor beta/gamma complex without engagement of the IL-2 receptor alpha. In mice, administration of THOR-707 results in large-scale activation and amplification of CD8
+ T cells and NK cells, without Treg expansion characteristic of IL-2. In syngeneic B16-F10 tumor-bearing mice, THOR-707 enhances drug accumulation in the tumor tissue, stimulates tumor-infiltrating CD8+ T and NK cells, and leads to a dose-dependent reduction of tumor growth. These results support further characterization of the immune modulatory, anti-tumor properties of THOR-707 and represent a fundamental advance in the application of synthetic biology to medicine, leveraging engineered semi-synthetic organisms as cellular factories to facilitate discovery and production of differentiated classes of chemically modified biologics., (© 2021. The Author(s).)- Published
- 2021
- Full Text
- View/download PDF
35. Mn-Doped BaTiO 3 Ceramics: Thermal and Electrical Properties for Multicaloric Applications.
- Author
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Semenov A, Dedyk A, Mylnikov I, Pakhomov O, Es'kov A, Anokhin A, Krylov V, Burovikhin A, Pavlova Y, Tselev A, and Kholkin A
- Abstract
Multiferroic materialsare widely used in microelectronics because they are sensitive to elastic, magnetic, and electric fields and there is an intrinsic coupling between them. In particular, transition metal-doped BaTiO
3 is consideredas a viable multiferroic because of the simultaneous presence of ferroelectricity and magnetism.In this work, we study the electrical and thermal properties of Mn-doped BaTiO3 ceramics that can be used for multicaloric applications. We found that Mn doping leads to the broadening and shifting of the phase transition accompanied with simultaneous decrease of latent heat and entropy. Mn doping causes a decrease in the bulk resistivity while contact resistance remains intact. Doped ceramics can withstand high electric fields(up to 40 kV/cm) and exhibit linear I-V characteristics followed by the Schottkylimited current in contrast to earlier observations. As such, these ceramics are promising for multicaloric applications., Competing Interests: The authors declare no conflicts of interest.- Published
- 2019
- Full Text
- View/download PDF
36. Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.
- Author
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Aznar N, Midde KK, Dunkel Y, Lopez-Sanchez I, Pavlova Y, Marivin A, Barbazán J, Murray F, Nitsche U, Janssen KP, Willert K, Goel A, Abal M, Garcia-Marcos M, and Ghosh P
- Subjects
- Humans, Frizzled Receptors metabolism, Heterotrimeric GTP-Binding Proteins metabolism, Intracellular Signaling Peptides and Proteins metabolism, Microfilament Proteins metabolism, Wnt Signaling Pathway
- Abstract
Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily. However, the mechanisms of G protein activation in Wnt signaling remain controversial. In this study, we demonstrate that FZDRs activate G proteins and trigger non-canonical Wnt signaling via the Dishevelled-binding protein, Daple. Daple contains a Gα-binding and activating (GBA) motif, which activates Gαi proteins and an adjacent domain that directly binds FZDRs, thereby linking Wnt stimulation to G protein activation. This triggers non-canonical Wnt responses, that is, suppresses the β-catenin/TCF/LEF pathway and tumorigenesis, but enhances PI3K-Akt and Rac1 signals and tumor cell invasiveness. In colorectal cancers, Daple is suppressed during adenoma-to-carcinoma transformation and expressed later in metastasized tumor cells. Thus, Daple activates Gαi and enhances non-canonical Wnt signaling by FZDRs, and its dysregulation can impact both tumor initiation and progression to metastasis.
- Published
- 2015
- Full Text
- View/download PDF
37. Antibacterial potential of streptomycete strains from Antarctic soils.
- Author
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Encheva-Malinova M, Stoyanova M, Avramova H, Pavlova Y, Gocheva B, Ivanova I, and Moncheva P
- Abstract
The exploration of habitats with unusual environment and poorly explored areas such as Antarctica is one of the strategies for discovery of new biologically active substances and/or new producers. The aim of this study was to identify the actinomycetes isolated from the soils of the island Livingston - Antarctica and to investigate their potential to synthesize antibacterial agents against phytopathogens. Twenty-three actinomycete strains were the object of this study. Using PCR (polymerase chain reaction) amplification all strains were affiliated to genus Streptomyces . The sequencing of the 16S rRNA for three of the strains showed greatest similarity to Streptomyces tendae for one of them, and revealed that the other strains had closest relations to streptomycetes isolated from anthropogenically unaltered regions including Antarctica. The isolates were studied for production of antibacterial substances both by molecular and culture methods. PCR targeting specific biosynthetic genes involved in the production of some groups of antibiotics was performed. The screening showed that all strains possessed the gene for Type-II polyketide synthase, 11 strains - for non-ribosomal peptide synthetase; 6 strains - for polyene antibiotics; and 4 strains - for glycopeptide antibiotics. The production of antibacterial substances by the strains was tested in vitro against phytopathogenic bacteria. The strains differed in the number of inhibited test - bacteria and in their spectrum of action. Four strains showed a wide range of activity against Gram-positive and Gram-negative phytopathogens. The results obtained revealed that the Antarctic soils are potential source for isolation of streptomycetes producing antibiotics from different groups.
- Published
- 2014
- Full Text
- View/download PDF
38. A game-theory based Multi-plant Collaboration Model (MCM) for cross-plant prevention in a chemical cluster.
- Author
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Reniers G, Cuypers S, and Pavlova Y
- Subjects
- Game Theory, Models, Theoretical
- Abstract
The presented Multi-plant Collaboration Model uses game theory to evaluate different strategic cross-plant precaution collaboration situations. The model first assumes prevention management's perceptions as a premise to take cross-plant prevention decisions. Second, it employs information from the different plants and aggregates the data to determine possible financial collaboration benefits within the entire industrial area. By doing so, an application of the model by a suggested independent supra-plant council may enhance and realize cross-corporation precaution in chemical clusters., (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
39. Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling.
- Author
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Garcia-Marcos M, Kietrsunthorn PS, Pavlova Y, Adia MA, Ghosh P, and Farquhar MG
- Subjects
- Amino Acid Motifs, Amino Acid Sequence, Cell Movement drug effects, GTP-Binding Protein alpha Subunits, Gi-Go metabolism, HeLa Cells, Humans, Insulin pharmacology, Lysophospholipids pharmacology, Models, Molecular, Molecular Sequence Data, Mutant Proteins chemistry, Mutant Proteins metabolism, Mutation genetics, Protein Binding drug effects, Proto-Oncogene Proteins c-akt metabolism, Stress Fibers drug effects, Stress Fibers metabolism, Guanine Nucleotide Exchange Factors chemistry, Microfilament Proteins chemistry, Microfilament Proteins metabolism, Signal Transduction drug effects, Vesicular Transport Proteins chemistry, Vesicular Transport Proteins metabolism
- Abstract
Heterotrimeric G proteins are critical signal-transducing molecules controlled by a complex network of regulators. GIV (a.k.a. Girdin) is a unique component of this network and a nonreceptor guanine nucleotide exchange factor (GEF) that functions via a signature motif. GIV's GEF motif is involved in the regulation of critical biological processes such as phosphoinositide 3 kinase (PI3K)-Akt signaling, actin cytoskeleton remodeling, cell migration, and cancer metastasis. Here we investigated how the GEF function of GIV affects the wiring of its signaling pathway to shape different biological responses. Using a structure-guided approach, we designed a battery of GIV mutants with different Gαi-binding and -activating properties and used it to dissect the specific impact of changes in GIV's GEF activity on several cellular responses. In vivo signaling assays revealed a threshold effect of GEF activity for the activation of Akt by GIV in different cell lines and by different stimuli. Akt signaling is minimal at low GEF activity and is sharply increased to reach a maximum above a threshold of GEF activity, suggesting that GIV is a critical signal amplifier and that activation of Akt is ultrasensitive to changes in GIV's GEF activity. A similar threshold dependence was observed for other biological functions promoted by GIV such as remodeling of the actin cytoskeleton and cell migration. This functional characterization of GIV's GEF motif provides insights into the molecular interactions between nonreceptor GEFs and G proteins and the mechanisms that govern this signal transduction pathway.
- Published
- 2012
- Full Text
- View/download PDF
40. Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.
- Author
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Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, Abagyan R, Garcia-Marcos M, and Ghosh P
- Subjects
- Analysis of Variance, Cell Line, Tumor, Chromatography, Liquid, Fluorescent Antibody Technique, Humans, Immunoprecipitation, Models, Molecular, Phosphorylation, Tandem Mass Spectrometry, Cell Movement physiology, Enzyme Activation physiology, Microfilament Proteins metabolism, Phosphatidylinositol 3-Kinase metabolism, Tyrosine metabolism, Vesicular Transport Proteins metabolism
- Abstract
GIV (Gα-interacting vesicle-associated protein; also known as Girdin) enhances Akt activation downstream of multiple growth factor- and G protein (heterotrimeric guanosine 5'-triphosphate-binding protein)-coupled receptors to trigger cell migration and cancer invasion. We demonstrate that GIV is a tyrosine phosphoprotein that directly binds to and activates phosphoinositide 3-kinase (PI3K). Upon ligand stimulation of various receptors, GIV was phosphorylated at tyrosine-1764 and tyrosine-1798 by both receptor and non-receptor tyrosine kinases. These phosphorylation events enabled direct binding of GIV to the amino- and carboxyl-terminal Src homology 2 domains of p85α, a regulatory subunit of PI3K; stabilized receptor association with PI3K; and enhanced PI3K activity at the plasma membrane to trigger cell migration. Tyrosine phosphorylation of GIV and its association with p85α increased during metastatic progression of a breast carcinoma. These results suggest a mechanism by which multiple receptors activate PI3K through tyrosine phosphorylation of GIV, thereby making the GIV-PI3K interaction a potential therapeutic target within the PI3K-Akt pathway.
- Published
- 2011
- Full Text
- View/download PDF
41. Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.
- Author
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Mittal Y, Pavlova Y, Garcia-Marcos M, and Ghosh P
- Subjects
- Animals, COS Cells, Chlorocebus aethiops, HeLa Cells, Humans, Microfilament Proteins genetics, Phosphatidylinositol 3-Kinases genetics, Phosphorylation physiology, Protein Binding, Protein Structure, Tertiary, Protein Tyrosine Phosphatase, Non-Receptor Type 6 genetics, Proto-Oncogene Proteins c-akt genetics, Vesicular Transport Proteins genetics, Microfilament Proteins metabolism, Phosphatidylinositol 3-Kinases metabolism, Protein Tyrosine Phosphatase, Non-Receptor Type 6 metabolism, Proto-Oncogene Proteins c-akt metabolism, Signal Transduction physiology, Vesicular Transport Proteins metabolism
- Abstract
GIV (Gα-interacting vesicle-associated protein, also known as Girdin) is a bona fide enhancer of PI3K-Akt signals during a diverse set of biological processes, e.g. wound healing, macrophage chemotaxis, tumor angiogenesis, and cancer invasion/metastasis. We recently demonstrated that tyrosine phosphorylation of GIV by receptor and non-receptor-tyrosine kinases is a key step that is required for GIV to directly bind and enhance PI3K activity. Here we report the discovery that Src homology 2-containing phosphatase-1 (SHP-1) is the major protein-tyrosine phosphatase that targets two critical phosphotyrosines within GIV and antagonizes phospho-GIV-dependent PI3K enhancement in mammalian cells. Using phosphorylation-dephosphorylation assays, we demonstrate that SHP-1 is the major and specific protein-tyrosine phosphatase that catalyzes the dephosphorylation of tyrosine-phosphorylated GIV in vitro and inhibits ligand-dependent tyrosine phosphorylation of GIV downstream of both growth factor receptors and GPCRs in cells. In vitro binding and co-immunoprecipitation assays demonstrate that SHP-1 and GIV interact directly and constitutively and that this interaction occurs between the SH2 domain of SHP-1 and the C terminus of GIV. Overexpression of SHP-1 inhibits tyrosine phosphorylation of GIV and formation of phospho-GIV-PI3K complexes, and specifically suppresses GIV-dependent activation of Akt. Consistently, depletion of SHP-1 enhances peak tyrosine phosphorylation of GIV, which coincides with an increase in peak Akt activity. We conclude that SHP-1 antagonizes the action of receptor and non-receptor-tyrosine kinases on GIV and down-regulates the phospho-GIV-PI3K-Akt axis of signaling.
- Published
- 2011
- Full Text
- View/download PDF
42. Soluble CD30 and Hepatocyte growth factor as predictive markers of antibody-mediated rejection of the kidney allograft.
- Author
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Pavlova Y, Viklicky O, Slatinska J, Bürgelova M, Süsal C, Skibova J, Honsová E, Striz I, Kolesar L, and Slavcev A
- Subjects
- Aged, Antibody Formation immunology, Biomarkers blood, Female, HLA Antigens immunology, Hepatocyte Growth Factor immunology, Humans, Isoantibodies immunology, Ki-1 Antigen immunology, Kidney Transplantation immunology, Male, Middle Aged, Retrospective Studies, Survival Rate, Time Factors, Transplantation, Homologous, Graft Rejection blood, Graft Rejection mortality, Hepatocyte Growth Factor blood, Isoantibodies blood, Ki-1 Antigen blood, Kidney Transplantation mortality
- Abstract
Unlabelled: Our retrospective study was aimed to assess the relevance of pre- and post-transplant measurements of serum concentrations of the soluble CD30 molecule (soluble CD30, sCD30) and the cytokine Hepatocyte growth factor (HGF) for prediction of the risk for development of antibody-mediated rejection (AMR) in kidney transplant patients. Evaluation of sCD30, HGF levels and the presence of HLA-specific antibodies in a cohort of 205 patients was performed before, 2weeks and 6months after transplantation. Patients were followed up for kidney graft function and survival for two years. We found a tendency of higher incidence of AMR in retransplanted patients with elevated pre-transplant sCD30 (≥100U/ml) (p=0.051), however no such correlation was observed in first-transplant patients. Kidney recipients with simultaneously high sCD30 and HLA-specific antibodies (sCD30+/Ab+) before transplantation had significantly lower AMR-free survival compared to the other patient groups (p<0.001). HGF concentrations were not associated with the incidence of AMR at any time point of measurement, nevertheless, the combined analysis HGF and sCD30 showed increased incidence of AMR in recipients with elevated pretransplant sCD30 and low HGF levels., Conclusion: the predictive value of pretransplant sCD30 for the development of antibody-mediated rejection after transplantation is significantly potentiated by the co-presence of HLA specific antibodies. The role of HGF as a rejection-protective factor in patients with high pretransplant HGF levels would need further investigation., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
43. A sequential-move game for enhancing safety and security cooperation within chemical clusters.
- Author
-
Pavlova Y and Reniers G
- Subjects
- Algorithms, Security Measures, Game Theory
- Abstract
The present paper provides a game theoretic analysis of strategic cooperation on safety and security among chemical companies within a chemical industrial cluster. We suggest a two-stage sequential move game between adjacent chemical plants and the so-called Multi-Plant Council (MPC). The MPC is considered in the game as a leader player who makes the first move, and the individual chemical companies are the followers. The MPC's objective is to achieve full cooperation among players through establishing a subsidy system at minimum expense. The rest of the players rationally react to the subsidies proposed by the MPC and play Nash equilibrium. We show that such a case of conflict between safety and security, and social cooperation, belongs to the 'coordination with assurance' class of games, and we explore the role of cluster governance (fulfilled by the MPC) in achieving a full cooperative outcome in domino effects prevention negotiations. The paper proposes an algorithm that can be used by the MPC to develop the subsidy system. Furthermore, a stepwise plan to improve cross-company safety and security management in a chemical industrial cluster is suggested and an illustrative example is provided., (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
44. Soluble CD30 in patients with antibody-mediated rejection of the kidney allograft.
- Author
-
Slavcev A, Honsova E, Lodererova A, Pavlova Y, Sajdlova H, Vitko S, Skibova J, Striz I, and Viklicky O
- Subjects
- Adult, Aged, Complement C4b analysis, Female, Humans, Male, Middle Aged, Peptide Fragments analysis, Transplantation, Homologous, Antibodies immunology, Graft Rejection immunology, Ki-1 Antigen analysis, Kidney Transplantation immunology
- Abstract
Unlabelled: The aim of our retrospective study was to evaluate the clinical significance of measurement of the soluble CD30 (sCD30) molecule for the prediction of antibody-mediated (humoral) rejection (HR). Sixty-two kidney transplant recipients (thirty-one C4d-positive and thirty-one C4d-negative patients) were included into the study. Soluble CD30 levels were evaluated before transplantation and during periods of graft function deterioration. The median concentrations of the sCD30 molecule were identical in C4d-positive and C4d-negative patients before and after transplantation (65.5 vs. 65.0 and 28.2 vs. 36.0 U/ml, respectively). C4d+ patients who developed DSA de novo had a tendency to have higher sCD30 levels before transplantation (80.7+/-53.6 U/ml, n=8) compared with C4d-negative patients (65.0+/-33.4 U/ml, n=15). Soluble CD30 levels were evaluated as positive and negative (>or=100 U/ml and <100 U/ml respectively) and the sensitivity, specificity and accuracy of sCD30 estimation with regard to finding C4d deposits in peritubular capillaries were determined. The sensitivity of sCD30+ testing was generally below 40%, while the specificity of the test, i.e. the likelihood that if sCD30 testing is negative, C4d deposits would be absent, was 82%. C4d+ patients who developed DSA de novo were evaluated separately; the specificity of sCD30 testing for the incidence of HR in this cohort was 86%., Conclusion: We could not confirm in our study that high sCD30 levels (>or=100 U/ml) might be predictive for the incidence of HR. Negative sCD30 values might be however helpful for identifying patients with a low risk for development of DSA and antibody-mediated rejection.
- Published
- 2007
- Full Text
- View/download PDF
45. Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.
- Author
-
Pebernard S, McDonald WH, Pavlova Y, Yates JR 3rd, and Boddy MN
- Subjects
- Amino Acid Sequence, Cell Cycle Proteins metabolism, Cell Nucleus metabolism, Cell Survival, Chromosomal Proteins, Non-Histone metabolism, Chromosomes ultrastructure, DNA Repair, Gamma Rays, Gene Deletion, Immunoblotting, Immunoprecipitation, Mitosis, Models, Biological, Molecular Sequence Data, Mutation, Nuclear Proteins genetics, Peptides chemistry, Protein Binding, Recombination, Genetic, Saccharomyces cerevisiae Proteins genetics, Schizosaccharomyces pombe Proteins genetics, Schizosaccharomyces pombe Proteins metabolism, Sequence Homology, Amino Acid, Two-Hybrid System Techniques, Ultraviolet Rays, Meiosis, Nuclear Proteins physiology, Saccharomyces cerevisiae Proteins physiology, Schizosaccharomyces physiology, Schizosaccharomyces pombe Proteins physiology
- Abstract
The structural maintenance of chromosomes (SMC) family of proteins play key roles in the organization, packaging, and repair of chromosomes. Cohesin (Smc1+3) holds replicated sister chromatids together until mitosis, condensin (Smc2+4) acts in chromosome condensation, and Smc5+6 performs currently enigmatic roles in DNA repair and chromatin structure. The SMC heterodimers must associate with non-SMC subunits to perform their functions. Using both biochemical and genetic methods, we have isolated a novel subunit of the Smc5+6 complex, Nse3. Nse3 is an essential nuclear protein that is required for normal mitotic chromosome segregation and cellular resistance to a number of genotoxic agents. Epistasis with Rhp51 (Rad51) suggests that like Smc5+6, Nse3 functions in the homologous recombination based repair of DNA damage. We previously identified two non-SMC subunits of Smc5+6 called Nse1 and Nse2. Analysis of nse1-1, nse2-1, and nse3-1 mutants demonstrates that they are crucial for meiosis. The Nse1 mutant displays meiotic DNA segregation and homologous recombination defects. Spore viability is reduced by nse2-1 and nse3-1, without affecting interhomolog recombination. Finally, genetic interactions shared by the nse mutants suggest that the Smc5+6 complex is important for replication fork stability.
- Published
- 2004
- Full Text
- View/download PDF
46. Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.
- Author
-
McDonald WH, Pavlova Y, Yates JR 3rd, and Boddy MN
- Subjects
- Alleles, Amino Acid Sequence, Cell Nucleus metabolism, Chromatin metabolism, Chromatography, Gel, DNA Damage, DNA-Binding Proteins physiology, Dimerization, Dose-Response Relationship, Radiation, Gene Deletion, Mass Spectrometry, Molecular Sequence Data, Mutation, Nuclear Proteins metabolism, Peptides chemistry, Phenotype, Rad51 Recombinase, Recombination, Genetic, Saccharomyces cerevisiae Proteins metabolism, Schizosaccharomyces, Schizosaccharomyces pombe Proteins metabolism, Schizosaccharomyces pombe Proteins physiology, Sequence Homology, Amino Acid, Temperature, Ultraviolet Rays, Cell Cycle Proteins chemistry, DNA Repair, Nuclear Proteins chemistry, Saccharomyces cerevisiae Proteins chemistry, Schizosaccharomyces pombe Proteins chemistry
- Abstract
The structural maintenance of chromosomes (SMC) family of proteins play essential roles in genomic stability. SMC heterodimers are required for sister-chromatid cohesion (Cohesin: Smc1 & Smc3), chromatin condensation (Condensin: Smc2 & Smc4), and DNA repair (Smc5 & Smc6). The SMC heterodimers do not function alone and must associate with essential non-SMC subunits. To gain further insight into the essential and DNA repair roles of the Smc5-6 complex, we have purified fission yeast Smc5 and identified by mass spectrometry the co-precipitating proteins, Nse1 and Nse2. We show that both Nse1 and Nse2 interact with Smc5 in vivo, as part of the Smc5-6 complex. Nse1 and Nse2 are essential proteins and conserved from yeast to man. Loss of Nse1 and Nse2 function leads to strikingly similar terminal phenotypes to those observed for Smc5-6 inactivation. In addition, cells expressing hypomorphic alleles of Nse1 and Nse2 are, like Smc5-6 mutants, hypersensitive to DNA damage. Epistasis analysis suggests that like Smc5-6, Nse1, and Nse2 function together with Rhp51 in the homologous recombination repair of DNA double strand breaks. The results of this study strongly suggest that Nse1 and Nse2 are novel non-SMC subunits of the fission yeast Smc5-6 DNA repair complex.
- Published
- 2003
- Full Text
- View/download PDF
47. Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9.
- Author
-
Soans C, Holash JA, Pavlova Y, and Pasquale EB
- Subjects
- Amino Acid Sequence, Animals, Antibody Specificity, Base Sequence, Cloning, Molecular, DNA, Complementary genetics, Molecular Sequence Data, Neuropeptides analysis, Organ Specificity, Phosphorylation, Receptor Protein-Tyrosine Kinases genetics, Receptor Protein-Tyrosine Kinases metabolism, Receptor, EphA4, Receptor, EphB2, Receptor, EphB5, Retina chemistry, Retina embryology, Sequence Analysis, DNA, Chick Embryo chemistry, Receptor Protein-Tyrosine Kinases analysis, Tyrosine metabolism
- Abstract
Cek9 is a receptor tyrosine kinase of the Eph subfamily for which only a partial cDNA sequence was known (Sajjadi, F.G., and E.B. Pasquale. 1993. Oncogene. 8:1807-1813). We have obtained the entire cDNA sequence and identified a variant form of Cek9 that lacks a signal peptide. We subsequently examined the spatio-temporal expression and tyrosine phosphorylation of Cek9 in the chicken embryo by using specific antibodies. At embryonic day 2, Cek9 immunoreactivity is concentrated in the eye, the brain, the posterior region of the neural tube, and the most recently formed somites. Later in development, Cek9 expression is widespread but particularly prominent in neural tissues. In the developing visual system, Cek9 is highly concentrated in areas containing retinal ganglion cell axons, suggesting a role in regulating their outgrowth to the optic tectum. Unlike other Eph-related receptors, Cek9 is substantially phosphorylated on tyrosine in many tissues at various developmental stages. Since autophosphorylation of receptor protein-tyrosine kinases typically correlates with increased enzymatic activity, this suggests that Cek9 plays an active role in embryonic signal transduction pathways.
- Published
- 1996
- Full Text
- View/download PDF
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