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Spectropolarimetric reconstructions of the photospheric vector magnetic field are intrinsically limited by the 180$^\circ$-ambiguity in the orientation of the transverse component. So far, the removal of such an ambiguity has required assumptions about the properties of the photospheric field, which makes disambiguation methods model-dependent. The basic idea is that the unambiguous line-of-sight component of the field measured from one vantage point will generally have a non-zero projection on the ambiguous transverse component measured by the second telescope, thereby determining the ``true'' orientation of the transverse field. Such an idea was developed and implemented in the Stereoscopic Disambiguation Method (SDM), which was recently tested using numerical simulations. In this work we present a first application of the SDM to data obtained by the High Resolution Telescope (HRT) onboard Solar Orbiter during the March 2022 campaign, when the angle with Earth was 27 degrees. The method is successfully applied to remove the ambiguity in the transverse component of the vector magnetogram solely using observations (from HRT and from the Helioseismic and Magnetic Imager), for the first time. The SDM is proven to provide observation-only disambiguated vector magnetograms that are spatially homogeneous and consistent. A discussion about the sources of error that may limit the accuracy of the method, and of the strategies to remove them in future applications, is also presented., 32 pages, 12 figures, accepted in A&A on 09/07/2023

The Solar Orbiter mission completed its first remote-sensing observation windows in the spring of 2022. On 2/4/2022, an M-class flare followed by a filament eruption was seen both by the instruments on board the mission and from several observatories in Earth's orbit. The complexity of the observed features is compared with the predictions given by the standard flare model in 3D. We use the observations from a multi-view dataset, which includes EUV imaging to spectroscopy and magnetic field measurements. These data come from IRIS, SDO, Hinode, as well as several instruments on Solar Orbiter. Information given by SDO/HMI and Solar Orbiter PHI/HRT shows that a parasitic polarity emerging underneath the filament is responsible for bringing the flux rope to an unstable state. As the flux rope erupts, Hinode/EIS captures blue-shifted emission in the transition region and coronal lines in the northern leg of the flux rope prior to the flare peak. Solar Orbiter SPICE captures the whole region, complementing the Doppler diagnostics of the filament eruption. Analyses of the formation and evolution of a complex set of flare ribbons and loops show that the parasitic emerging bipole plays an important role in the evolution of the flaring region. While the analysed data are overall consistent with the standard flare model, the present particular magnetic configuration shows that surrounding magnetic activity such as nearby emergence needs to be taken into account to fully understand the processes at work. This filament eruption is the first to be covered from different angles by spectroscopic instruments, and provides an unprecedented diagnostic of the multi-thermal structures present before and during the flare. This dataset of an eruptive event showcases the capabilities of coordinated observations with the Solar Orbiter mission., Accepted for publication in the Astronomy & Astrophysics special edition "Solar Orbiter First Results (Nominal Mission Phase)" (23/05/2023)

Context. The Extreme Ultraviolet Imager (EUI), onboard Solar Orbiter consists of three telescopes: the two High Resolution Imagers in EUV (HRIEUV) and in Lyman-{\alpha} (HRILya), and the Full Sun Imager (FSI). Solar Orbiter/EUI started its Nominal Mission Phase on 2021 November 27. Aims. EUI images from the largest scales in the extended corona off limb, down to the smallest features at the base of the corona and chromosphere. EUI is therefore a key instrument for the connection science that is at the heart of the Solar Orbiter mission science goals. Methods. The highest resolution on the Sun is achieved when Solar Orbiter passes through the perihelion part of its orbit. On 2022 March 26, Solar Orbiter reached for the first time a distance to the Sun close to 0.3 au. No other coronal EUV imager has been this close to the Sun. Results. We review the EUI data sets obtained during the period 2022 March-April, when Solar Orbiter quickly moved from alignment with the Earth (2022 March 6), to perihelion (2022 March 26), to quadrature with the Earth (2022 March 29). We highlight the first observational results in these unique data sets and we report on the in-flight instrument performance. Conclusions. EUI has obtained the highest resolution images ever of the solar corona in the quiet Sun and polar coronal holes. Several active regions were imaged at unprecedented cadences and sequence durations. We identify in this paper a broad range of features that require deeper studies. Both FSI and HRIEUV operate at design specifications but HRILya suffered from performance issues near perihelion. We conclude emphasising the EUI open data policy and encouraging further detailed analysis of the events highlighted in this paper.

Context: On 2020 May 30, small and short-lived EUV brightenings were observed in the Quiet Sun (QS) during a four minutes sequence by EUI/HRIEUV on board Solar Orbiter. Their physical origin and possible impact on coronal or Transition Region (TR) heating are still to be determined. Aims: Our aim is to derive the statistical thermal evolution of these events in order to establish their coronal or TR origin. Methods. Our thermal analysis takes advantage of the multithermal sensitivity of the Atmospheric Imaging Assembly (AIA) imager on board the Solar Dynamics Observatory (SDO). We first identified these HRIEUV events in the six coronal bands of AIA. We then performed a statistical time lag analysis, which quantifies the delays between the light curves from different bands. These time lags can give significant insights into the temperature evolution of these events. The analysis is performed taking into account the possible contribution to the results from the background and foreground emissions. Results: The events are characterized by time lags inferior to the AIA cadence of 12 s, for all nine couples of AIA bands analyzed. Our interpretation is the possible co-presence of events which reach or do not reach coronal temperatures ($\approx$ 1MK). We believe that the cool population dominates the events analyzed in this work., 14 pages, 8 figures, language and typo editing, accepted in A&A

ispartof: ASTRONOMY & ASTROPHYSICS vol:662 status: published

The mRNA-destabilizing protein tristetraprolin (TTP), encoded by the ZFP36 gene, is known to be able to end inflammatory responses by directly targeting and destabilizing mRNAs encoding pro-inflammatory cytokines. We analyzed its role in psoriasis, a disease characterized by chronic inflammation. We observed that TTP is downregulated in fibroblasts deriving from psoriasis patients compared to those deriving from healthy individuals and that psoriatic fibroblasts exhibit abnormal inflammasome activity compared to their physiological counterpart. This phenomenon depends on TTP downregulation. In fact, following restoration, TTP is capable of directly targeting for degradation NLRP3 mRNA, thereby drastically decreasing inflammasome activation. Moreover, we provide evidence that ZFP36 undergoes methylation in psoriasis, by virtue of the presence of long stretches of CpG dinucleotides both in the promoter and the coding region. Besides confirming that a perturbation of TTP expression might underlie the pathogenesis of psoriasis, we suggest that deregulated inflammasome activity might play a role in the disease alongside deregulated cytokine expression.

International audience; Abstract The magnetic activity of the Sun directly impacts the Earth and human life. Likewise, other stars will have an impact on the habitability of planets orbiting these host stars. Although the magnetic field at the surface of the Sun is reasonably well characterised by observations, the information on the magnetic field in the higher atmospheric layers is mainly indirect. This lack of information hampers our progress in understanding solar magnetic activity. Overcoming this limitation would allow us to address four paramount long-standing questions: (1) How does the magnetic field couple the different layers of the atmosphere, and how does it transport energy? (2) How does the magnetic field structure, drive and interact with the plasma in the chromosphere and upper atmosphere? (3) How does the magnetic field destabilise the outer solar atmosphere and thus affect the interplanetary environment? (4) How do magnetic processes accelerate particles to high energies? New ground-breaking observations are needed to address these science questions. We suggest a suite of three instruments that far exceed current capabilities in terms of spatial resolution, light-gathering power, and polarimetric performance: (a) A large-aperture UV-to-IR telescope of the 1-3 m class aimed mainly to measure the magnetic field in the chromosphere by combining high spatial resolution and high sensitivity. (b) An extreme-UV-to-IR coronagraph that is designed to measure the large-scale magnetic field in the corona with an aperture of about 40 cm. (c) An extreme-UV imaging polarimeter based on a 30 cm telescope that combines high throughput in the extreme UV with polarimetry to connect the magnetic measurements of the other two instruments. Placed in a near-Earth orbit, the data downlink would be maximised, while a location at L4 or L5 would provide stereoscopic observations of the Sun in combination with Earth-based observatories. This mission to measure the magnetic field will finally unlock the driver of the dynamics in the outer solar atmosphere and thereby will greatly advance our understanding of the Sun and the heliosphere.

International audience; Solar Orbiter is the first space mission observing the solar plasma both in situ and remotely, from a close distance, in and out of the ecliptic. The ultimate goal is to understand how the Sun produces and controls the heliosphere, filling the Solar System and driving the planetary environments. With six remote-sensing and four in-situ instrument suites, the coordination and planning of the operations are essential to address the following four top-level science questions: (1) What drives the solar wind and where does the coronal magnetic field originate?; (2) How do solar transients drive heliospheric variability?; (3) How do solar eruptions produce energetic particle radiation that fills the heliosphere?; (4) How does the solar dynamo work and drive connections between the Sun and the heliosphere? Maximising the mission's science return requires considering the characteristics of each orbit, including the relative position of the spacecraft to Earth (affecting downlink rates), trajectory events (such as gravitational assist manoeuvres), and the phase of the solar activity cycle. Furthermore, since each orbit's science telemetry will be downloaded over the course of the following orbit, science operations must be planned at mission level, rather than at the level of individual orbits. It is important to explore the way in which those science questions are translated into an actual plan of observations that fits into the mission, thus ensuring that no opportunities are missed. First, the overarching goals are broken down into specific, answerable questions along with the required observations and the so-called Science Activity Plan (SAP) is developed to achieve this. The SAP groups objectives that require similar observations into Solar Orbiter Observing Plans, resulting in a strategic, top-level view of the optimal opportunities for science observations during the mission lifetime. This allows for all four mission goals to be addressed. In this paper, we introduce Solar Orbiter's SAP through a series of examples and the strategy being followed.

International audience; Aims. The Spectral Imaging of the Coronal Environment (SPICE) instrument is a high-resolution imaging spectrometer operating at extreme ultraviolet (EUV) wavelengths. In this paper, we present the concept, design, and pre-launch performance of this facility instrument on the ESA/NASA Solar Orbiter mission. Methods. The goal of this paper is to give prospective users a better understanding of the possible types of observations, the data acquisition, and the sources that contribute to the instrument's signal. Results. The paper discusses the science objectives, with a focus on the SPICE-specific aspects, before presenting the instrument's design, including optical, mechanical, thermal, and electronics aspects. This is followed by a characterisation and calibration of the instrument's performance. The paper concludes with descriptions of the operations concept and data processing. Conclusions. The performance measurements of the various instrument parameters meet the requirements derived from the mission's science objectives. The SPICE instrument is ready to perform measurements that will provide vital contributions to the scientific success of the Solar Orbiter mission.

Background MetabERN is one of the 24 European Reference Networks created according to the European Union directive 2011/24/EU on patient’s rights in cross border healthcare. MetabERN associates 69 centres in 18 countries, which provide care for patients with Hereditary Metabolic Diseases, and have the mission to reinforce research and provide training for health professionals in this field. MetabERN performed a survey in December 2017 with the aim to produce an overview documenting research activities and potentials within the network. As the centres are multidisciplinary, separated questionnaires were sent to the clinical, university and laboratory teams. Answers were received from 52 out of the 69 centres of the network, covering 16 countries. A descriptive analysis of the information collected is presented. Results The answers indicate a marked interest of the respondents for research, who expressed high motivation and commitment, and estimated that the conditions to do research in their institution were mostly satisfactory. They are active in research, which according to several indicators, is competitive and satisfies standards of excellence, as well as the education programs offered in the respondent’s universities. Research in the centres is primarily performed in genetics, pathophysiology, and epidemiology, and focuses on issues related to diagnosis. Few respondents declared having activity in human and social sciences, including research on patient’s quality of life, patient’s awareness, or methods for social support. Infrastructures offering services for medical research were rarely known and used by respondents, including national and international biobanking platforms. In contrast, respondents often participate to patient registries, even beyond their specific field of interest. Conclusions Taken as a whole, these results provide an encouraging picture of the research capacities and activities in the MetabERN network, which, with respect to the number and representativeness of the investigated centres, gives a comprehensive picture of research on Hereditary Metabolic Diseases in Europe, as well as the priorities for future actions. Marginal activity in human and social sciences points out the limited multidisciplinary constitution of the responding teams with possible consequences on their current capability to participate to patient’s empowerment programs and efficiently collaborate with patient’s advocacy groups. Electronic supplementary material The online version of this article (10.1186/s13023-019-1091-8) contains supplementary material, which is available to authorized users.

Flares are localized phenomena in active regions, but the magnetic and plasma responses may propagate to a larger area. In this work we investigate the temporal evolution of a flare in an active region with particular attention to the morphological details, and to the temperature and emission measure diagnostics allowed by Hinode/XRT.

In this work we investigate the fine thermal structure of a flare observed in November 2006 by Hinode/XRT. For this analysis we adopted a new technique which optimizes the use of five different filters, resulting in a good diagnostic of temperature.

We investigate possible diagnostics of the thermal structure of coronal loops from Hinode/XRT observations made with several filters. We consider the observation of an active region with five filters. We study various possible combinations of filter data to optimize for sensitivity to thermal structure and for signal enhancement.

International audience