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Purpose Image processing plays a fundamental role in the study of central nervous system, for example in the analysis of the vascular network in neurodegenerative diseases. Synchrotron X-ray Phase-contrast micro-Tomography (SXPCT) is a very attractive method to study weakly absorbing samples and features, such as the vascular network in the spinal cord (SC). However, the identification and segmentation of vascular structures in SXPCT images is seriously hampered by the presence of image noise and strong contrast inhomogeneities, due to the sensitivity of the technique to small electronic density variations. In order to help with these tasks, we implemented a user-friendly ImageJ plugin based on a 3D Gaussian steerable filter, tuned up for the enhancement of tubular structures in SXPCT images. Methods The developed 3D Gaussian steerable filter plugin for ImageJ is based on the steerability properties of Gaussian derivatives. We applied it to SXPCT images of ex-vivo mouse SCs acquired at different experimental conditions. Results The filter response shows a strong amplification of the source image contrast-to-background ratio (CBR), independently of structures orientation. We found that after the filter application, the CBR ratio increases by a factor ranging from ~6 to ~60. In addition, we also observed an increase of 35% of the contrast to noise ratio in the case of injured mouse SC. Conclusion The developed tool can generally facilitate the detection/segmentation of capillaries, veins and arteries that were not clearly observable in non-filtered SXPCT images. Its systematic application could allow obtaining quantitative information from pre-clinical and clinical images.

The simulation of large biomolecules and biological assemblies requires to achieve an optimal balance between physical realism and computational efficiency. We describe how an effective strategy is based on a dual representation, whereby macromolecules are described by means of a coarse grained, particle-based representation, while aqueous solvent and electrolytes are represented by a mesoscopic, kinetic treatment. The joint usage of the Molecular Dynamics and Lattice Boltzmann techniques provides an optimal combination for these representations and allows simulating from proteins to polynucleotides under a wide range of equilibrium and off-equilibrium conditions.

By exploiting two ACS/HST datasets separated by a temporal baseline of ~7 years, we have determined the relative stellar proper motions (providing membership) and the absolute proper motion of the Galactic globular cluster M71. The absolute proper motion has been used to reconstruct the cluster orbit within a Galactic, three-component, axisymmetric potential. M71 turns out to be in a low latitude disk-like orbit inside the Galactic disk, further supporting the scenario in which it lost a significant fraction of its initial mass. Since large differential reddening is known to affect this system, we took advantage of near-infrared, ground-based observations to re-determine the cluster center and density profile from direct star counts. The new structural parameters turn out to be significantly different from the ones quoted in the literature. In particular, M71 has a core and a half-mass radii almost 50% larger than previously thought. Finally we estimate that the initial mass of M71 was likely one order of magnitude larger than its current value, thus helping to solve the discrepancy with the observed number of X-ray sources., Accepted for publication in ApJ

By exploiting two sets of high-resolution images obtained with HST ACS/WFC over a baseline of ~10 years we have measured relative proper motions of ~70,000 stars in the stellar system Terzan 5. The results confirm the membership of the three sub-populations with different iron abudances discovered in the system. The orbit of the system has been derived from a first estimate of its absolute proper motion, obtained by using bulge stars as reference. The results of the integration of this orbit within an axisymmetric Galactic model exclude any external accretion origin for this cluster. Terzan 5 is known to have chemistry similar to the Galactic bulge; our findings support a kinematic link between the cluster and the bulge, further strengthening the possibility that Terzan 5 is the fossil remnant of one of the pristine clumps that originated the bulge., 25 pages, 14 figures, accepted for publication by ApJ

We present the first evidence of clear signatures of tidal distortions in the density distribution of the fascinating open cluster NGC 6791. We used deep and wide-field data obtained with the Canada-France-Hawaii-Telescope covering a 2x2 square degrees area around the cluster. The two-dimensional density map obtained with the optimal matched filter technique shows a clear elongation and an irregular distribution starting from ~300" from the cluster center. At larger distances, two tails extending in opposite directions beyond the tidal radius are also visible. These features are aligned to both the absolute proper motion and to the Galactic center directions. Moreover, other overdensities appear to be stretched in a direction perpendicular to the Galactic plane. Accordingly to the behaviour observed in the density map, we find that both the surface brightness and the star count density profiles reveal a departure from a King model starting from ~600" from the center. These observational evidence suggest that NGC 6791 is currently experiencing mass loss likely due to gravitational shocking and interactions with the tidal field. We use this evidence to argue that NGC 6791 should have lost a significant fraction of its original mass. A larger initial mass would in fact explain why the cluster survived so long. Using available recipes based on analytic studies and N-body simulations, we derived the expected mass loss due to stellar evolution and tidal interactions and estimated the initial cluster mass to be M_ini=(1.5-4) x 10^5 M_sun., Comment: Accepted for publication in the MNRAS (9 pages, 8 Figures)

We used high-quality images acquired with the Wide Field Camera 3 on board the Hubble Space Telescope to probe the blue straggler star (BSS) population of the galactic globular cluster NGC 362. We have found two distinct sequences of BSSs: this is the second case, after M30, where such a feature has been observed. Indeed, the BSS location, their extension in magnitude and color, and their radial distribution within the cluster nicely resemble those observed in M30, thus suggesting that the same interpretative scenario can be applied: the red BSS sub-population is generated by mass-transfer binaries, the blue one by collisions. The discovery of four new W UMa stars, three of which lie along the red BSS sequence, further supports this scenario. We also found that the inner portion of the density profile deviates from a King model and is well reproduced by either a mild power law (α ~ -0.2) or a double King profile. This feature supports the hypothesis that the cluster is currently undergoing the core-collapse phase. Moreover, the BSS radial distribution shows a central peak and monotonically decreases outward without any evidence of an external rising branch. This evidence is a further indication of the advanced dynamical age of NGC 362 in fact, together with M30, NGC 362 belongs to the family of dynamically old clusters (Family III) in the "dynamical clock" classification proposed by Ferraro et al. The observational evidence presented here strengthens the possible connection between the existence of a double BSS sequence and a quite advanced dynamical status of the parent cluster.

By combining high spatial resolution and wide-field spectroscopy performed, respectively, with SINFONI and FLAMES at the ESO/VLT we measured the radial velocities of more than 600 stars in the direction of NGC 6388, a Galactic globular cluster which is suspected to host an intermediate-mass black hole. Approximately 55% of the observed targets turned out to be cluster members. The cluster velocity dispersion has been derived from the radial velocity of individual stars: 52 measurements in the innermost 2", and 276 stars located between 18" and 600". The velocity dispersion profile shows a central value of ~13 km/s, a flat behavior out to ~60" and a decreasing trend outwards. The comparison with spherical and isotropic models shows that the observed density and velocity dispersion profiles are inconsistent with the presence of a central black hole more massive than ~2000 Msol. These findings are at odds with recent results obtained from integrated light spectra, showing a velocity dispersion profile with a steep central cusp of 23-25 km/s at r, Comment: Accepted for publication by ApJ; 38 pages, 3 tables, 15 figures

Context. The problem of the existence of intermediate-mass black holes (IMBHs) at the centre of globular clusters is a hot and controversial topic in current astrophysical research with important implications in stellar and galaxy formation. Aims. In this paper, we aim at giving further support to the presence of an IMBH in omega Centauri and at providing an independent estimate of its mass. Methods. We employed a self-consistent spherical model with anisotropic velocity distribution. It consists in a generalisation of the King model by including the Bahcall-Wolf distribution function in the IMBH vicinity. Results. By the parametric fitting of the model to recent HST/ACS data for the surface brightness profile, we found an IMBH to cluster total mass ratio of M_BH/M = 5.8(+0.9-1.2) x 10^(-3). It is also found that the model yields a fit of the line-of-sight velocity dispersion profile that is better without mass segregation than in the segregated case. This confirms the current thought of a non-relaxed status for this peculiar cluster. The best fit model to the kinematic data leads, moreover, to a cluster total mass estimate of M = (3.1 +/- 0.3) x 10^6 Msol, thus giving an IMBH mass in the range 13,000 < M_BH < 23,000 Msol (at 1-sigma confidence level). A slight degree of radial velocity anisotropy in the outer region (r > 12') is required to match the outer surface brightness profile., LateX, 5 pages, 5 figures. Accepted for publication by Astronomy & Astrophysics

We report the detection of a stellar density cusp and a velocity dispersion increase in the center of the globular cluster M54, located at the center of the Sagittarius dwarf galaxy (Sgr). The central line of sight velocity dispersion is 20.2 +/- 0.7 km/s, decreasing to 16.4 +/- 0.4 km/s at 2.5" (0.3 pc). Modeling the kinematics and surface density profiles as the sum of a King model and a point-mass yields a black hole (BH) mass of ~ 9400 M_sun. However, the observations can alternatively be explained if the cusp stars possess moderate radial anisotropy. A Jeans analysis of the Sgr nucleus reveals a strong tangential anisotropy, probably a relic from the formation of the system., Accepted for publication by The Astrophysical Journal (Letters). Latex. 5 pages, 4 color figures, 2 with reduced resolution, one in greyscale. A full-resolution color version of the paper can be retrieved from http://www.bo.astro.it/SGR/Sgr_BH.pdf

In the last decade, observational studies have shown the existence of tidal streams in the outer part of many galactic globular clusters. The most striking examples of clusters with well defined tidal tails are represented by Palomar 5 and NGC 5466 (both observed in the framework of the Sloan Digital Sky Survey), which show structures elongated for 4 kpc and 1 kpc in length, respectively. Unfortunately, most of the observational studies about globular clusters (GCs) do not cover such a large field of the sky as the SDSS does. In this framework, by mean of a parallel, adaptive tree-code, we performed detailed N-body simulations of GCs moving in a realistic three-components (bulge, disk and halo) Milky Way potential, in order to clarify whether and to what extent tails in the clusters outer regions (few tidal radii) are tracers of the local orbits and, also, if some kind of correlation exists among the cluster orbital phase and the orientation of such streams., LaTeX, 2 pages, 1 figure. Contribution to "Globular Clusters: Guides to Galaxies", March 6th-10th, 2006

We present results of fully self-consistent N-body simulations of the motion of four globular clusters moving in the inner region of their parent galaxy. With regard to previous simplified simulations, we confirm merging and formation of an almost steady nuclear cluster, in a slightly shorter time. The projected surface density profile shows strong similarity to that of resolved galactic nuclei. This similarity reflects also in the velocity dispersion profile which exhibits a central colder component as observed in many nucleated galaxies., Comment: 5 pages, 6 figures, submitted to MNRAS letters

By means of a multimass isotropic and spherical model that includes the self-consistent treatment of a central intermediate-mass black hole (IMBH), the influence of this black hole on the morphological and physical properties of globular clusters is investigated. In agreement with recent numerical studies, it is found that a cluster (with mass M) hosting an IMBH (with mass M_BH) shows, outside the region of gravitational influence of the black hole, a core-like profile resembling a King profile with concentration c < 2, although with a slightly steeper behaviour in the core region. In particular, the core logarithmic slope is s < 0.25 for reasonably low IMBH masses (M_BH < M/100), and c decreases monotonically with M_BH. Completely power-law density profiles (similar to, for example, those of collapsed clusters) are admitted only in the presence of a black hole with an unrealistic M_BH > M. The mass range estimate 12s - 4.8 < log (M_BH/M)< -1.1c - 0.69, depending on the morphological parameters, is deduced by considering a wide range of models. Applying this estimate to a set of 39 globular clusters, it is found that NGC 2808, NGC 6388, M80, M13, M62, M54 and G1 (in M31) probably host an IMBH. For them, the scaling laws M_BH ~ 0.09(M/M_sol)^{0.7} M_sol and M_BH ~ 50[sigma/ (km s^-1)]^{1.2} M_sol are identified from weighted least-squares fits. An important result of this 'collective' study is that a strong correlation exists between the presence of an extreme blue horizontal branch and the presence of an IMBH. In particular, the presence of a central IMBH in M13 and NGC 6388 could explain why these clusters possess extreme horizontal-branch stars, in contrast to their 'second parameter' counterparts M3 and 47 Tuc., LaTeX, 15 pages, 8 figures, 4 tables included. Final version with new G1 data. Accepted for publication on MNRAS. The definitive version is available at www.blackwell-synergy.com

We have used a combination of high resolution (HST ACS-HRC, ACS-WFC, and WFPC2) and wide-field (ESO-WFI) observations of the galactic globular cluster NGC 6388 to derive its center of gravity, projected density profile, and central surface brightness profile. While the overall projected profiles are well fit by a King model with intermediate concentration (c=1.8) and sizable core radius (rc=7"), a significant power law (with slope \alpha=-0.2) deviation from a flat core behavior has been detected within the inner 1 arcsecond. These properties suggest the presence of a central intermediate mass black hole. The observed profiles are well reproduced by a multi-mass isotropic, spherical model including a black hole with a mass of ~5.7x10^3 Msol., Comment: ApJ Letter in press

In this paper, we present some preliminary results of numerical simulations of a globular cluster orbiting in the inner region of a triaxial galaxy. The formation and evolution of tidal tails around the cluster is discussed, together with their morphology, which shows clumpy substructures as observed, for example, in the galactic globular cluster Palomar 5.

We present preliminary results on the parallelization of a Tree-Code for evaluating gravitational forces in N-body astrophysical systems. Our HPF/CRAFT implementation on a CRAY T3E machine attained an encouraging speed-up behavior, reaching a value of 75 with 128 processor elements (PEs). The speed-up tests regard the evaluation of the forces among N = 130,369 particles distributed scaling the actual distribution of a sample of galaxies of the Leda catalog., Latex, 3 pages, 2 ps figures; presented at the 1998 Conference on Computational Physics, Granada (Spain), sept. 2-5, 1998, in press in Comp. Phys. Comm. (Elsevier pub.)