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307 results on '"Oyama, Genko"'

1. Digital detection of Alzheimer’s disease using smiles and conversations with a chatbot

Author

Takeshige-Amano, Haruka, Oyama, Genko, Ogawa, Mayuko, Fusegi, Keiko, Kambe, Taiki, Shiina, Kenta, Ueno, Shin-ichi, Okuzumi, Ayami, Hatano, Taku, Motoi, Yumiko, Kawakami, Ito, Ando, Maya, Nakayama, Sachiko, Ishida, Yoshinori, Maei, Shun, Lu, Xiangxun, Kobayashi, Tomohisa, Wooden, Rina, Ota, Susumu, Morito, Ken, Ito, Yoshitaka, Nakajima, Yoshihiro, Yoritaka, Asako, Kato, Tadafumi, and Hattori, Nobutaka

Published
2024
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6. Analytical and clinical validity of wearable, multi-sensor technology for assessment of motor function in patients with Parkinson’s disease in Japan

Author

Oyama, Genko, Burq, Maximilien, Hatano, Taku, Marks, Jr, William J., Kapur, Ritu, Fernandez, Jovelle, Fujikawa, Keita, Furusawa, Yoshihiko, Nakatome, Keisuke, Rainaldi, Erin, Chen, Chen, Ho, King Chung, Ogawa, Takashi, Kamo, Hikaru, Oji, Yutaka, Takeshige-Amano, Haruka, Taniguchi, Daisuke, Nakamura, Ryota, Sasaki, Fuyuko, Ueno, Shinichi, Shiina, Kenta, Hattori, Anri, Nishikawa, Noriko, Ishiguro, Mayu, Saiki, Shinji, Hayashi, Ayako, Motohashi, Masatoshi, and Hattori, Nobutaka

Published
2023
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9. Expert teleconsultation involving patients and their primary neurologists for the management of multiple sclerosis in regions without specialists.

Author

Miyazaki, Yusei, Ura, Shigehisa, Horiuchi, Kazuhiro, Matsuoka, Takeshi, Houzen, Hideki, Tsuzaka, Kazufumi, Makino, Yuichi, Koshida, Manami, Oyama, Genko, Sato, Chika, Naganuma, Ryoji, Amino, Itaru, Akimoto, Sachiko, Niino, Masaaki, Minami, Naoya, Takahashi, Eri, Ota, Susumu, Hattori, Nobutaka, Yabe, Ichiro, and Kikuchi, Seiji

Subjects
INFORMATION technology, VIDEOCONFERENCING, HOSPITAL patients, TIME management, HEALTH equity
Abstract

Objective: This study aimed to describe the usefulness of our teleconsultation system for managing multiple sclerosis (MS) in regions without specialists. Methods: A cross‐sectional questionnaire survey involving 11 MS patients and their primary neurologists was carried out between May and December 2023. Real‐time video conferences were conducted between an MS specialist at a hub hospital and patients with their primary neurologists at one of the four regional core hospitals in Hokkaido, Japan. Patients and their primary neurologists completed questionnaires to evaluate the usefulness of the teleconsultation system. Results: The patients and their primary neurologists were generally satisfied with the teleconsultations and expressed willingness to continue using the system. In particular, alleviating the burden of visiting distant MS‐specialized clinics was highly appreciated by patients. In addition, patients gave high scores for questions regarding increased satisfaction with the primary neurologists' care and the treatments they offered. The primary neurologists thought the system enhanced their knowledge of MS management. However, they did not think that the system could ease their burden for managing MS patients because of challenges in time allocation and scheduling for teleconsultation sessions. Conclusions: The present study suggested that our expert teleconsultation system for MS reduces the burden on patients of visiting distant MS‐specialized clinics, and enhances knowledge of MS management for the primary neurologists. It also promotes trust between patients and their primary neurologists, and taken together, these aspects could collectively lead to independent and sustainable MS management in regions without MS specialists. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis

Author

Nagino, Ken, Sung, Jaemyoung, Oyama, Genko, Hayano, Motoshi, Hattori, Nobutaka, Okumura, Yuichi, Fujio, Kenta, Akasaki, Yasutsugu, Huang, Tianxiang, Midorikawa-Inomata, Akie, Fujimoto, Keiichi, Eguchi, Atsuko, Hurramhon, Shokirova, Miura, Maria, Ohno, Mizu, Hirosawa, Kunihiko, Morooka, Yuki, Murakami, Akira, Kobayashi, Hiroyuki, and Inomata, Takenori

Published
2022
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14. Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan

Author

Li, Yuanzhe, Ikeda, Aya, Yoshino, Hiroyo, Oyama, Genko, Kitani, Mitsuhiro, Daida, Kensuke, Hayashida, Arisa, Ogaki, Kotaro, Yoshida, Kousuke, Kimura, Takashi, Nakayama, Yoshiaki, Ito, Hidefumi, Sugeno, Naoto, Aoki, Masashi, Miyajima, Hiroaki, Kimura, Katsuo, Ueda, Naohisa, Watanabe, Masao, Urabe, Takao, Takanashi, Masashi, Funayama, Manabu, Nishioka, Kenya, and Hattori, Nobutaka

Published
2020
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17. Efficacy and Safety of Elobixibat in Parkinson's Disease with Chronic Constipation: CONST‐PD Study.

Author

Hatano, Taku, Oyama, Genko, Shimo, Yasushi, Ogaki, Kotaro, Nishikawa, Noriko, Nakamura, Ryota, Tsunemi, Taiji, Ogawa, Takashi, Eguchi, Hiroto, Daida, Kensuke, Kurita, Naohide, Ueno, Shin‐ichi, Fukae, Jiro, Sako, Wataru, Shiina, Kenta, Nakajima, Sho, Oji, Yutaka, Wakamori, Ryo, Saiki, Shinji, and Nishioka, Kenya

Subjects
*PARKINSON'S disease, *CHRONIC diseases, *PATIENT satisfaction, *CONSTIPATION, *ANALYSIS of covariance
Abstract

Background: Chronic constipation is a common digestive complication of Parkinson's disease (PD). Objectives: To verify the usefulness of elobixibat, an ileal bile acid transporter inhibitor, for chronic constipation in PD. Methods: This double‐blind, placebo‐controlled study consisted of a 2‐week observation/washout period and a 4‐week treatment period. All patients received a Bowel Movement Diary at Week ‐2 and were allocated to elobixibat (10 mg) or placebo at Week 0. Patients visited at Weeks 2 and 4 to report daily spontaneous bowel movements (SBM), stool form, drug use, quality of life (QOL), and safety. Changes in these parameters were assessed. Results: The study included 38 patients in the elobixibat group and 39 in the placebo group, and 37 each completed the study. SBM frequency/week (mean ± standard deviation) increased significantly from 4.2 ± 2.6 at baseline to 5.9 ± 3.2 at Week 4 in the elobixibat group (P = 0.0079), but not in the placebo group (4.5 ± 2.7 to 5.3 ± 3.5; P = 0.0889). On analysis of covariance, the between‐group difference in frequency changes at Week 4 (primary endpoint) was not significant after adjustment by baseline and sex (point estimate = 0.8; 95% confidence interval = −0.57 to 2.09, P = 0.2601), although a significant difference (P = 0.0011) was evidenced at Week 1 by a similar analysis. Stool form and scores of satisfaction and stigma were improved by elobixibat. Adverse events were as previously reported. Conclusions: Elobixibat improved the SBM frequency, though the defined primary endpoint was not evidenced. QOL parameters (stool consistency and treatment satisfaction) were also improved. Elobixibat may have therapeutic benefits in PD patients suffering from chronic constipation. Trial Registration Information: Trial Registration Number: JPRN‐jRCTs031200172 (submitted: October 26, 2020; first patient enrolment: December 23, 2020; https://jrct.niph.go.jp/en-latest-detail/jRCTs031200172). [ABSTRACT FROM AUTHOR]

Published
2024
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23. Editorial: Remote monitoring technologies in neurodegenerative movement disorders.

Author

Oyama, Genko, Tsamis, Konstantinos, Konitsiotis, Spyridon, and Metman, Leonard Verhagen

Subjects
MOVEMENT disorders, NEURODEGENERATION, MACHINE learning, NATURAL language processing, TELEPSYCHIATRY, HUNTINGTON disease
Abstract

This article discusses the use of remote monitoring technologies in neurodegenerative movement disorders such as Parkinson's disease and Huntington's disease. These disorders can significantly impact a patient's quality of life due to the progressive impairment of motor control. Remote monitoring technologies, such as wearable sensors and non-contact sensors, allow for continuous and accurate monitoring of symptoms in the context of daily life. Advances in artificial intelligence and data analytics can extract useful insights from this data to support personalized treatment plans. However, there are still unresolved issues related to data privacy, cost, and customization that need to be addressed. Overall, remote monitoring technologies have the potential to improve the quality of life for patients with movement disorders and enable more effective symptom management. [Extracted from the article]

Published
2024
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29. GCH1 mutations in dopa-responsive dystonia and Parkinson’s disease

Author

Yoshino, Hiroyo, Nishioka, Kenya, Li, Yuanzhe, Oji, Yutaka, Oyama, Genko, Hatano, Taku, Machida, Yutaka, Shimo, Yasushi, Hayashida, Arisa, Ikeda, Aya, Mogushi, Kaoru, Shibagaki, Yasuro, Hosaka, Ai, Iwanaga, Hiroshi, Fujitake, Junko, Ohi, Takekazu, Miyazaki, Daigo, Sekijima, Yoshiki, Oki, Mitsuaki, Kusaka, Hirofumi, Fujimoto, Ken-ichi, Ugawa, Yoshikazu, Funayama, Manabu, and Hattori, Nobutaka

Published
2018
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30. Long‐Read Sequencing Resolves a Complex Structural Variant in PRKN Parkinson's Disease.

Author

Daida, Kensuke, Funayama, Manabu, Billingsley, Kimberley J., Malik, Laksh, Miano‐Burkhardt, Abigail, Leonard, Hampton L., Makarious, Mary B., Iwaki, Hirotaka, Ding, Jinhui, Gibbs, J. Raphael, Ishiguro, Mayu, Yoshino, Hiroyo, Ogaki, Kotaro, Oyama, Genko, Nishioka, Kenya, Nonaka, Risa, Akamatsu, Wado, Blauwendraat, Cornelis, and Hattori, Nobutaka

Abstract

Background: Parkin RBR E3 ubiquitin‐protein ligase (PRKN) mutations are the most common cause of young onset and autosomal recessive Parkinson's disease (PD). PRKN is located in FRA6E, which is one of the common fragile sites in the human genome, making this region prone to structural variants. However, complex structural variants such as inversions of PRKN are seldom reported, suggesting that there are potentially unrevealed complex pathogenic PRKN structural variants. Objectives: To identify complex structural variants in PRKN using long‐read sequencing. Methods: We investigated the genetic cause of monozygotic twins presenting with a young onset dystonia‐parkinsonism using targeted sequencing, whole exome sequencing, multiple ligation probe amplification, and long‐read sequencing. We assessed the presence and frequency of complex inversions overlapping PRKN using whole‐genome sequencing data of Accelerating Medicines Partnership Parkinson's disease (AMP‐PD) and United Kingdom (UK)‐Biobank datasets. Results: Multiple ligation probe amplification identified a heterozygous exon three deletion in PRKN and long‐read sequencing identified a large novel inversion spanning over 7 Mb, including a large part of the coding DNA sequence of PRKN. We could diagnose the affected subjects as compound heterozygous carriers of PRKN. We analyzed whole genome sequencing data of 43,538 participants of the UK‐Biobank and 4941 participants of the AMP‐PD datasets. Nine inversions in the UK‐Biobank and two in AMP PD were identified and were considered potentially damaging and likely to affect PRKN expression. Conclusions: This is the first report describing a large 7 Mb inversion involving breakpoints outside of PRKN. This study highlights the importance of using long‐read sequencing for structural variant analysis in unresolved young‐onset PD cases. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. [ABSTRACT FROM AUTHOR]

Published
2023
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42. List of contributors

Author

Artusi, Carlo Alberto, Balachandar, Arjun, Bhidayasiri, Roongroj, Bordallo López, Miguel, Bouça-Machado, Raquel, Cacho, Ricardo, Choudhury, Supriyo, Del Din, Silvia, Deuschl, Günther, Espay, Alberto J., Fasano, Alfonso, Ferreira, Joaquim J., Gandolfi, Marialuisa, Goetz, Christopher G., Imbalzano, Gabriele, Kauppila, Linda Azevedo, Kumar, Hrishikesh, Lage Cañellas, Manuel, Leitão, Mariana, Leyens, Lada, Maetzler, Walter, Mancini, Martina, Mari, Zoltan, Mathur, Soania, Mirelman, Anat, Monje, Mariana H.G., Nguyen, Le, Nobbs, David, Oyama, Genko, Padovani, Alessandro, Paul, Serene S., Phokaewvarangkul, Onanong, Pilotto, Andrea, Prasertpan, Tittaya, Ray Chaudhuri, K., Rehman, Rana Zia Ur, Rizzardi, Andrea, Salaorni, Francesca, Schönberg, Laura, Simuni, Tanya, Sánchez-Ferro, Álvaro, Susarla, Praneeth, Tinazzi, Michele, Álvarez Casado, Constantino, Tönges, Lars, van Wamelen, Daniel J., Virameteekul, Sasivimol, Vizcarra, Joaquin A., and Zatti, Cinzia

Published
2024
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