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132 results on '"Oshima, Shuichi"'

1. Validation of the obesity paradox by body mass index and waist circumference in patients undergoing percutaneous coronary intervention

Author

Shirahama, Yuichiro, Tabata, Noriaki, Sakamoto, Kenji, Sato, Ryota, Yamanaga, Kenshi, Fujisue, Koichiro, Sueta, Daisuke, Araki, Satoshi, Takashio, Seiji, Arima, Yuichiro, Hokimoto, Seiji, Sato, Koji, Sakamoto, Tomohiro, Nakao, Koichi, Shimomura, Hideki, Matsumura, Toshiyuki, Tayama, Shinji, Fujimoto, Kazuteru, Oshima, Shuichi, Nakamura, Shinichi, Tsunoda, Ryusuke, Hirose, Toyoki, Kikuta, Koichi, Sakaino, Naritsugu, Yamamoto, Nobuyasu, Kajiwara, Ichiro, Suzuki, Satoru, Yamamoto, Eiichiro, Kaikita, Koichi, Matsushita, Kenichi, and Tsujita, Kenichi

Published
2022
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2. Impact of cerebrovascular comorbidity on prognosis in Japanese patients undergoing PCI: 1-year data from Japanese multicenter registry (KICS)

Author

Ahmed, Khlood, Arima, Yuichiro, Tabata, Noriaki, Ishii, Masanobu, Sato, Ryota, Yamashita, Takayoshi, Yamanaga, Kenshi, Takizawa, Hitoshi, Hokimoto, Seiji, Sueta, Daisuke, Araki, Satoshi, Fujisue, Koichiro, Takashio, Seiji, Fujimoto, Kazuteru, Shimomura, Hideki, Tsunoda, Ryusuke, Hirose, Toyoki, Sato, Koji, Kikuta, Koichi, Sakaino, Naritsugu, Nakamura, Shinichi, Yamamoto, Nobuyasu, Matsumura, Toshiyuki, Kajiwara, Ichiro, Tayama, Shinji, Sakamoto, Tomohiro, Nakao, Koichi, Oshima, Shuichi, Yamamoto, Eiichiro, Sakamoto, Kenji, Kaikita, Koichi, Matsushita, Kenichi, and Tsujita, Kenichi

Published
2022
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3. Temporal trends in coronary intervention strategies and the impact on one-year clinical events: data from a Japanese multi-center real-world cohort study

Author

Sakamoto, Kenji, Sato, Ryota, Tabata, Noriaki, Ishii, Masanobu, Yamashita, Takayoshi, Nagamatsu, Suguru, Motozato, Kota, Yamanaga, Kenshi, Hokimoto, Seiji, Sueta, Daisuke, Araki, Satoshi, Fujisue, Koichiro, Arima, Yuichiro, Takashio, Seiji, Fujimoto, Kazuteru, Shimomura, Hideki, Tsunoda, Ryusuke, Hirose, Toyoki, Sato, Koji, Kikuta, Koichi, Sakaino, Naritsugu, Nakamura, Shinichi, Yamamoto, Nobuyasu, Matsumura, Toshiyuki, Kajiwara, Ichiro, Tayama, Shinji, Sakamoto, Tomohiro, Nakao, Koichi, Oshima, Shuichi, Yamamoto, Eiichiro, Kaikita, Koichi, and Tsujita, Kenichi

Published
2022
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5. Lipid profile associated with coronary plaque regression in patients with acute coronary syndrome: Subanalysis of PRECISE-IVUS trial

Author

Tsujita, Kenichi, Yamanaga, Kenshi, Komura, Naohiro, Sakamoto, Kenji, Sugiyama, Seigo, Sumida, Hitoshi, Shimomura, Hideki, Yamashita, Takuro, Oka, Hideki, Nakao, Koichi, Nakamura, Sunao, Ishihara, Masaharu, Matsui, Kunihiko, Sakaino, Naritsugu, Nakamura, Natsuki, Yamamoto, Nobuyasu, Koide, Shunichi, Matsumura, Toshiyuki, Fujimoto, Kazuteru, Tsunoda, Ryusuke, Morikami, Yasuhiro, Matsuyama, Koushi, Oshima, Shuichi, Kaikita, Koichi, Hokimoto, Seiji, and Ogawa, Hisao

Published
2016
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6. Prognostic impact of spontaneous coronary artery dissection in young female patients with acute myocardial infarction: A report from the Angina Pectoris–Myocardial Infarction Multicenter Investigators in Japan

Author

Nakashima, Takahiro, Noguchi, Teruo, Haruta, Seiichi, Yamamoto, Yusuke, Oshima, Shuichi, Nakao, Koichi, Taniguchi, Yasuyo, Yamaguchi, Junichi, Tsuchihashi, Kazufumi, Seki, Atsushi, Kawasaki, Tomohiro, Uchida, Tatsuro, Omura, Nobuhiro, Kikuchi, Migaku, Kimura, Kazuo, Ogawa, Hisao, Miyazaki, Shunichi, and Yasuda, Satoshi

Published
2016
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18. A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese

Author

Iida, Aritoshi, Takahashi, Atsushi, Kubo, Michiaki, Saito, Susumu, Hosono, Naoya, Ohnishi, Yozo, Kiyotani, Kazuma, Mushiroda, Taisei, Nakajima, Masahiro, Ozaki, Kouichi, Tanaka, Toshihiro, Tsunoda, Tatsuhiko, Oshima, Shuichi, Sano, Motoki, Kamei, Tetsumasa, Tokuda, Torao, Aoki, Masashi, Hasegawa, Kazuko, Mizoguchi, Koichi, Morita, Mitsuya, Takahashi, Yuji, Katsuno, Masahisa, Atsuta, Naoki, Watanabe, Hirohisa, Tanaka, Fumiaki, Kaji, Ryuji, Nakano, Imaharu, Kamatani, Naoyuki, Tsuji, Shoji, Sobue, Gen, Nakamura, Yusuke, and Ikegawa, Shiro

Published
2011
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19. Impact of statin-ezetimibe combination on coronary atheroma plaque in patients with and without chronic kidney disease — Sub-analysis of PRECISE-IVUS trial

Author

Fujisue, Koichiro, Nagamatsu, Suguru, Shimomura, Hideki, Yamashita, Takuro, Nakao, Koichi, Nakamura, Sunao, Ishihara, Masaharu, Matsui, Kunihiko, Yamamoto, Nobuyasu, Koide, Shunichi, Matsumura, Toshiyuki, Fujimoto, Kazuteru, Tsunoda, Ryusuke, Morikami, Yasuhiro, Matsuyama, Koshi, Oshima, Shuichi, Sakamoto, Kenji, Izumiya, Yasuhiro, Kaikita, Koichi, Hokimoto, Seiji, Ogawa, Hisao, and Tsujita, Kenichi

Published
2018
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27. Clinical outcomes of percutaneous coronary intervention (PCI) at hospital with or without onsite cardiac surgery backup

Author

Akasaka, Tomonori, Hokimoto, Seiji, Oshima, Shuichi, Nakao, Koichi, Fujimoto, Kazuteru, Miyao, Yuji, Shimomura, Hideki, Tsunoda, Ryusuke, Hirose, Toyoki, Kajiwara, Ichiro, Matsumura, Toshiyuki, Nakamura, Natsuki, Yamamoto, Nobuyasu, Koide, Shunichi, Oka, Hideki, Morikami, Yasuhiro, Sakaino, Naritsugu, Kaikita, Koichi, Nakamura, Sunao, Matsui, Kunihiko, and Ogawa, Hisao

Published
2014
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30. Dose-dependent INhibitory effect of rosuVastatin In Japanese patienTs with Acute myocardial infarcTION on serum concentration of matrix metalloproteinases – INVITATION trial.

Author

Fujisue, Koichiro, Shirakawa, Takuhiro, Nakamura, Shinichi, Yamamoto, Nobuyasu, Oshima, Shuichi, Matsumura, Toshiyuki, Tsunoda, Ryusuke, Hirai, Nobutaka, Tayama, Shinji, Nakamura, Natsuki, Hirose, Toyoki, Maruyama, Hideki, Fujimoto, Kazuteru, Kajiwara, Ichiro, Sakamoto, Tomohiro, Nakao, Koichi, Sakaino, Naritsugu, Hokimoto, Seiji, Nagayoshi, Yasuhiro, and Hokamaki, Jun

Abstract

Background Acute myocardial infarction (AMI) is mainly characterized by the rupture of lipid-rich vulnerable atherosclerotic plaque. The matrix metalloproteinases (MMPs) have been shown to play a critical role in inflammatory processes underlying plaque rupture. Some reports suggested statins inhibit the increased MMP levels after AMI. However, there are a few comparison studies between the different dosages of the same statin and circulating levels of MMPs. Purpose This study will preliminarily investigate the potential effects of appropriate or low dose of rosuvastatin on circulating MMPs levels in AMI patients. Moreover, we will also obtain plasma from patients while undergoing diagnostic angiography to determine differences in various cardiac sites and peripheral vessels. Methods This study is a multicenter, open-label, randomized, parallel-group study to be conducted to compare the appropriate or low dose of rosuvastatin in the effect on serum levels of inflammatory markers in AMI patients. The eligible patients undergoing percutaneous coronary intervention (PCI) will be randomly assigned to receive either appropriate or low-dose rosuvastatin daily using a web-based randomization software within 24 h after PCI. The low-dose group will be treated with rosuvastatin 2.5 mg once daily with a follow-up. The appropriate-dose group will begin treatment with rosuvastatin 5 mg once daily, and the dose of rosuvastatin will be titrated to 10 mg within 4 weeks. During administration of the study treatment, subjects will undergo laboratory testing including MMPs and be monitored for the occurrence of adverse events up to 24 weeks. The primary endpoint will be the change rate of MMPs at 24 weeks after administration. Conclusions INVITATION will compare the appropriate or low dose of rosuvastatin in the effects on serum levels of inflammatory markers including MMPs in AMI patients. This study will provide significant information on rosuvastatin as an anti-inflammatory agent for AMI. [ABSTRACT FROM AUTHOR]

Published
2018
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31. Clinical outcomes of percutaneous coronary intervention for acute coronary syndrome between hospitals with and without onsite cardiac surgery backup.

Author

Akasaka, Tomonori, Hokimoto, Seiji, Sueta, Daisuke, Tabata, Noriaki, Oshima, Shuichi, Nakao, Koichi, Fujimoto, Kazuteru, Miyao, Yuji, Shimomura, Hideki, Tsunoda, Ryusuke, Hirose, Toyoki, Kajiwara, Ichiro, Matsumura, Toshiyuki, Nakamura, Natsuki, Yamamoto, Nobuyasu, Koide, Shunichi, Nakamura, Shinichi, Morikami, Yasuhiro, Sakaino, Naritsugu, and Kaikita, Koichi

Abstract

Background Based on the 2011 American College of Cardiology/American Heart Association percutaneous coronary intervention (PCI) guideline, it is recommended that PCI should be performed at hospital with onsite cardiac surgery. But, data suggest that there is no significant difference in clinical outcomes following primary or elective PCI between the two groups. We examined the impact of with or without onsite cardiac surgery on clinical outcomes following PCI for acute coronary syndrome (ACS). Methods and results From August 2008 to March 2011, subjects ( n = 3241) were enrolled from the Kumamoto Intervention Conference Study (KICS). Patients were assigned to two groups treated in hospitals with ( n = 2764) or without ( n = 477) onsite cardiac surgery. Clinical events were followed up for 12 months. Primary endpoint was in-hospital death, cardiovascular death, myocardial infarction, and stroke. And we monitored in-hospital events, non-cardiovascular deaths, bleeding complications, revascularizations, and emergent coronary artery bypass grafting (CABG). There was no overall significant difference in primary endpoint between hospitals with and without onsite cardiac surgery [ACS, 7.6% vs. 8.0%, p = 0.737; ST-segment elevation myocardial infarction (STEMI), 10.4% vs. 7.5%, p = 0.200]. There was also no significant difference when events in primary endpoint were considered separately. In other events, revascularization was more frequently seen in hospitals with onsite surgery (ACS, 20.0% vs. 13.0%, p < 0.001; STEMI, 21.9% vs. 14.5%, p = 0.009). We performed propensity score matching analysis to correct for the disparate patient numbers between the two groups, and there was also no significant difference for primary endpoint (ACS, 8.6% vs. 7.5%, p = 0.547; STEMI, 11.2% vs. 7.5%, p = 0.210). Conclusions There is no significant difference in clinical outcomes following PCI for ACS between hospitals with and without onsite cardiac surgery backup in Japan. [ABSTRACT FROM AUTHOR]

Published
2017
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34. Impact of candesartan on cardiovascular events after drug-eluting stent implantation in patients with coronary artery disease: The 4C trial.

Author

Sakamoto, Tomohiro, Ogawa, Hisao, Nakao, Koichi, Hokimoto, Seiji, Tsujita, Kenichi, Koide, Shunichi, Yamamoto, Nobuyasu, Shimomura, Hideki, Matsumura, Toshiyuki, Oshima, Shuichi, Kikuta, Koichi, Oka, Hideki, Kimura, Kazuo, and Matsui, Kunihiko

Abstract

Objective The purpose of this study was to examine the cardiovascular protective effects of candesartan in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Background Candesartan has been reported to reduce cardiovascular events when therapy was started 6 months after PCI with bare-metal stents in patients who survived restenosis. Candesartan started immediately after PCI with DESs was also effective in preventing cardiovascular events. Methods The 4C trial was a multicenter, prospective, randomized, open-label study. A total of 1145 patients at 39 centers in Japan were randomly assigned to receive candesartan plus standard medical treatment or standard medical treatment alone. The primary endpoints were all-cause death, and a composite of non-fatal myocardial infarction (MI), unstable angina pectoris (uAP), congestive heart failure (CHF), and non-fatal cerebrovascular events. The follow-up period was up to 3 years after the index PCI (ClinicalTrials.gov NCT00139386 ). Results The incidence of total death, one of the primary endpoints, was comparable between the two treatment groups (3.8% each, p = 0.9702). Another primary endpoint, non-fatal major cardiovascular events, tended to occur more often in the control group than in the candesartan group (9.2% vs. 12.5%, p = 0.0985). In contrast, candesartan significantly reduced one of the pre-specified secondary endpoints: cardiovascular events that included non-fatal MI, uAP, and CHF (4.4% vs. 6.7%, p = 0.0136). Furthermore, candesartan significantly reduced another secondary endpoint that included cardiovascular events and cardiovascular death (5.0% vs. 7.7%, p = 0.0493). Conclusions The 4C trial showed that candesartan administered immediately after PCI with DESs did not improve the prognosis after the index procedure, but did reduce some cardiac-related events for 3 years. [ABSTRACT FROM AUTHOR]

Published
2016
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35. Improved image quality at 256-slice coronary CT angiography in patients with a high heart rate and coronary artery disease: comparison with 64-slice CT imaging.

Author

Oda, Seitaro, Katahira, Kazuhiro, Utsunomiya, Daisuke, Takaoka, Hiroko, Honda, Keiichi, Noda, Katsuo, Oshima, Shuichi, Yuki, Hideaki, Namimoto, Tomohiro, and Yamashita, Yasuyuki

Subjects
ADRENERGIC beta blockers, COMPUTED tomography, CORONARY disease, DIAGNOSTIC imaging, HEART beat, COMPUTERS in medicine, RADIATION doses, RETROSPECTIVE studies, CORONARY angiography, PHARMACODYNAMICS
Abstract

Background: The 256-slice computed tomography (CT) scanners with wider detector coverage and faster gantry rotation speed are now available. The performance of scanners that feature a rotation speed of 270 ms at coronary CT angiography (CCTA) has not been evaluated in patients with a higher heart rate.Purpose: To evaluate the image quality of 256-slice CT with faster gantry rotation speed in patients undergoing CCTA.Material and Methods: We enrolled 886 patients; 357(40.3%) underwent study on a 64-slice CT at a rotation speed of 420 ms, the other 529 (59.7%) were examined using a 256-slice CT scanner at 270 ms. Two observers judged the image quality of 2658 imaged coronary arteries on a 4-point scale.Results: The mean image quality score was significantly higher for the 256 - than the 64-slice CT scans (3.94 ± 0.28 vs. 3.73 ± 0.61; P < 0.01). There was no significant difference in the image quality scores between 64 - and 256-slice scans in patients whose heart rate (HR) was <60 bpm. However, in patients whose HR exceeded 60 bpm these scores were significantly higher for 256-slice CT images (P < 0.01).Conclusion: CCTA performed on the 256-slice CT scanner yielded significantly better image quality in patients with an HR exceeding 60 bpm. [ABSTRACT FROM AUTHOR]

Published
2015
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38. Impact of Dual Lipid-Lowering Strategy With Ezetimibe and Atorvastatin on Coronary Plaque Regression in Patients With Percutaneous Coronary Intervention The Multicenter Randomized Controlled PRECISE-IVUS Trial

Author

Tsujita, Kenichi, Sugiyama, Seigo, Sumida, Hitoshi, Shimomura, Hideki, Yamashita, Takuro, Yamanaga, Kenshi, Komura, Naohiro, Sakamoto, Kenji, Oka, Hideki, Nakao, Koichi, Nakamura, Sunao, Ishihara, Masaharu, Matsui, Kunihiko, Sakaino, Naritsugu, Nakamura, Natsuki, Yamamoto, Nobuyasu, Koide, Shunichi, Matsumura, Toshiyuki, Fujimoto, Kazuteru, Tsunoda, Ryusuke, Morikami, Yasuhiro, Matsuyama, Koushi, Oshima, Shuichi, Kaikita, Koichi, Hokimoto, Seiji, and Ogawa, Hisao

Subjects
lipids (amino acids, peptides, and proteins), HMG-CoA reductase inhibitors, cardiovascular diseases, intravascular ultrasound
Abstract

BackgroundDespite standard statin therapy, a majority of patients retain a high “residual risk” of cardiovascular events.ObjectivesThe aim of this study was to evaluate the effects of ezetimibe plus atorvastatin versus atorvastatin monotherapy on the lipid profile and coronary atherosclerosis in Japanese patients who underwent percutaneous coronary intervention (PCI).MethodsThis trial was a prospective, randomized, controlled, multicenter study. Eligible patients who underwent PCI were randomly assigned to atorvastatin alone or atorvastatin plus ezetimibe (10 mg) daily. Atorvastatin was uptitrated with a treatment goal of low-density lipoprotein cholesterol (LDL-C)

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39. Low contrast material dose coronary computed tomographic angiography using a dual-layer spectral detector system in patients at risk for contrast-induced nephropathy.

Author

Oda, Seitaro, Nakaura, Takeshi, Nagayama, Yasunori, Taguchi, Narumi, Kidoh, Masafumi, Utsunomiya, Daisuke, Yamashita, Yasuyuki, Takaoka, Hiroko, Katahira, Kazuhiro, Honda, Keiichi, Funama, Yoshinori, Noda, Katsuo, and Oshima, Shuichi

Subjects
CORONARY angiography, DIAGNOSTIC imaging, KIDNEY injuries, ACUTE kidney failure, GLOMERULAR filtration rate
Abstract

To evaluate the effects of virtual monochromatic imaging (VMI) using dual-layer spectral detector CT on the image quality of coronary CT angiography (CCTA) acquired by using a low contrast material (CM) dose. We used a VMI 50keV protocol with a 50% CM dose (140 mgI kg–1) to scan 30 patients with renal insufficiency and a 120 kVp with the standard CM dose (280 mgI kg–1) to scan 30 controls without renal insufficiency. Quantitative parameters, including CT attenuation, image noise, and contrast-to-noise ratio (CNR), were measured. The visual image quality factors of contrast enhancement, image noise, beam-hardening artefact, vessel sharpness, and overall image quality were scored on a 4-point scale. The mean CT attenuation of the ascending aorta was significantly higher for 50 keV VMI than for 120 kVp. Image noise was significantly lower under the 50 keV VMI. CNR and the mean visual score for contrast enhancement were significantly higher for 50 keV VMI. There were no significant differences in the other visual image quality parameters between the two protocols. Dual-layer spectral detector CT using 50 keV VMI enabled reducing the CM dose by 50 % without CCAT image quality degradation in patients with renal insufficiency. The VMI 50 keV protocol using dual-layer spectral detector CT and a CM dose reduced by 50 % (140 mgI kg–1) can improve the diagnostic image quality of CCTA. [ABSTRACT FROM AUTHOR]

Published
2019
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41. Abstract 14566: Impact of Silent Myocardial Ischemia on One Year Mortality After Successful Coronary Intervention: Data From Japanese Multicenter (KICS) Registry.

Author

Motozato, Kota, Sakamoto, Kenji, Yamashita, Takayoshi, Nagamatsu, Suguru, Sato, Ryota, Hokimoto, Seiji, Oshima, Shuichi, Nakao, Koich, Fuijimoto, Kazuteru, Miyao, Yuji, Shimomura, Hideki, Tsunoda, Ryusuke, Maruyama, Hideki, Hirose, Toyoki, Sueta, Daisuke, Araki, Satoshi, Arima, Yuichiro, Nakamura, Sunao, Kaikita, Koichi, and Tsujita, Kenichi

Published
2018

48. Pericardial fat inflammation correlates with coronary artery disease

Author

Konishi, Masaaki, Sugiyama, Seigo, Sato, Yuichiro, Oshima, Shuichi, Sugamura, Koichi, Nozaki, Toshimitsu, Ohba, Keisuke, Matsubara, Junichi, Sumida, Hitoshi, Nagayoshi, Yasuhiro, Sakamoto, Kenji, Utsunomiya, Daisuke, Awai, Kazuo, Jinnouchi, Hideaki, Matsuzawa, Yasushi, Yamashita, Yasuyuki, Asada, Yujiro, Kimura, Kazuo, Umemura, Satoshi, and Ogawa, Hisao

Subjects
*CORONARY disease, *FAT, *INFLAMMATION, *PERICARDIUM, *ADIPOSE tissues, *CARDIOGRAPHIC tomography, *ATHEROSCLEROSIS, *OBESITY
Abstract

Abstract: Objectives: We sought to assess the association between inflammation in pericardial fat (PF) and coronary artery disease (CAD) by pathological examination and clinical evaluation with cardiac computed tomography (CT). Background: Inflammation of adipose tissue is involved in cardio-metabolic disorders and shows high density in CT. Methods: We quantified, by immunohistochemical means, the PF inflammation in 39 autopsy cases by counting leukocyte common antigen (LCA)-positive cells. We then measured the CT density of PF in 39 patients with acute coronary syndromes and 69 patients suspected of CAD. Results: Pericoronary PF had significantly more LCA-positive cells in CAD autopsy cases (n =21) than non-CAD cases (n =18) (44±21 vs. 24±22 cells/mm2, p =0.006). The CT density of PF around culprit lesions was significantly higher than non-culprit lesions in patients with acute coronary syndromes (−72±11 vs. −82±14HU, p =0.002), which may reflect PF inflammation. Among patients suspected of CAD, the pericardial CT density gradient (PDG; difference in CT density between pericoronary PF and PF apart from coronary arteries) was significantly greater in CAD patients (n =30) than non-CAD patients (n =39) (22±16 vs. 16±10HU, p =0.046). Multiple logistic regression analysis demonstrated that the PF inflammation index (PFI; PDG×PF volume, which could be the integrated index of inflammatory activity and abundance of PF) was significantly associated with the presence of CAD (odds ratio [95% confidence interval]; 1.234 [1.012–1.503] per 1000HUcm3, p =0.037) independent of other metabolic risk factors such as hypertension, dyslipidemia, and diabetes. Conclusions: Active inflammation in PF correlates with CAD. PF inflammation may be involved in pathogenesis of CAD. [ABSTRACT FROM AUTHOR]

Published
2010
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49. Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque

Author

Miyata, Keishi, Nakayama, Masafumi, Mizuta, Shoko, Hokimoto, Seiji, Sugamura, Koichi, Oshima, Shuichi, Oike, Yuichi, Sugiyama, Seigo, Ogawa, Hisao, and Yamamura, Ken-ichi

Subjects
*MACROPHAGES, *ENDARTERECTOMY, *MUSCLE cells, *ATHEROSCLEROSIS
Abstract

Abstract: We previously reported that the mouse α/β hydrolase domain containing 2 (Abhd2) was expressed in smooth muscle cells (SMCs) which suppressed their migration and inhibited the development of intimal hyperplasia by cuff placement; however, the role of ABHD2 in human remains to be elucidated. In this study, we examined ABHD2 expression in the human coronary atherosclerotic lesions of the patients with unstable angina (UA) and stable angina (SA). Our results showed that the ABHD2 was expressed in atherosclerotic lesions, and that the ABHD2 expression was significantly higher in the patients with UA than with SA. Immunohistochemistry analysis revealed abundant expression of ABHD2 in macrophages, but low expression in SMCs of atherosclerotic lesions. Using human vascular primary culture cell lines, we also demonstrated that the expression of ABHD2 was significantly higher in macrophages than in SMCs, and that the expression of ABHD2 significantly increased proportionally with differentiation from monocyte into macrophage. [Copyright &y& Elsevier]

Published
2008
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