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2. The Development of Mental State Attributions in Women with X-Monosomy, and the Role of Monoamine Oxidase B in the Sociocognitive Phenotype

Author

Lawrence, K., Jones, A., and Oreland, L.

Abstract

We hypothesized that women with Turner syndrome (45,X) with a single X-chromosome inherited from their mother may show mentalizing deficits compared to women of normal karyotype with two X-chromosomes (46,X). Simple geometrical animation events (two triangles moving with apparent intention in relation to each other) which usually elicit mental-state descriptions in normally developing people, did not do so to the same extent in women with Turner syndrome. We then investigated the potential role in this deficit played by monoamine oxidase B enzymatic activity. MAO-B activity reflects central serotonergic activity, and by implication the functional integrity of neural circuits implicated in mentalizing. Platelet MAO-B was substantially reduced in Turner syndrome. However, contrary to prediction, in this (relatively small) sample there was no association between MAO-B enzymatic activity and mentalizing skills in participants with and without Turner syndrome.

Published
2007
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32. Association between Transcription Factor AP-2B genotype, obesity, insulin resistance and dietary intake in a longitudinal birth cohort study Transcription Factor AP-2B associated with obesity

Author

Joost, U., Harro, J., Veidebaum, L., Oreland, L., Comasco, E., and Villa, I.

Abstract

This is a post-peer-review, pre-copyedit version of an article published in International Journal of Obesity., The development of obesity has a large genetic component, and the gene encoding the transcription factor 2 beta (TFAP2B) has been identified as one of the responsible factors. We investigated the effect of TFAP2B intron 2 variable number tandem repeat (VNTR) genotype on obesity, insulin resistance and dietary intake from 15 to 33 years of age.

Published
2019

47. COMT genotype and non-recovery after a whiplash injury in a Northern European population.

Author

Rydman, Eric, Comasco, Erika, Pettersson, H., Oreland, L., Ponzer, S., and Ottosson, C.

Subjects
CATECHOL-O-methyltransferase, WHIPLASH injuries, SINGLE nucleotide polymorphisms, MEDICAL genetics, CHRONIC pain
Abstract

Background: The COMT (Catechol-O-Methyl Transferase) gene may influence a person's vulnerability to develop long-term pain and some COMT single nucleotide polymorphisms (SNPs) may associate with patterns of acute or chronic pain. Many patients with whiplash-associated disorders (WADs) suffer from long-term pain and other related symptoms, but it is less known if genetic factors play a role in the recovery process. The primary aim of this study was to evaluate whether self-reported non-recovery, including pain, was related to COMT genotype in patients with WAD. The secondary aim was to investigate whether or not background factors, including mental health, were related to genotype and non-recovery.Methods: A total of 133 patients with neck pain after a whiplash trauma were included. Background factors were collected and blood samples were taken during the acute phase after the accident. DNA was isolated from blood and used to genotype the SNPs rs6269, rs4633, rs4818 and rs4680 in the COMT gene; additionally haplotypes were estimated and haplogenotypes inferred. The patients were followed up after 12 months and asked to rate their recovery including pain, mental health and quality of life.Results: The overall reported non-recovery rate at 12 months was 44% with no significant differences in distribution of the COMT haplotypes. High levels of self-reported pain (OR 7.2) and anxiety (OR 4.4) after the accident were associated with non-recovery, but not related to the haplotypes. None of the other background factors were related to the haplotypes or non-recovery.Conclusion: No association between self-reported non-recovery or pain levels and COMT haplotypes in patients with acute whiplash injuries could be detected. Independent replications are necessary to discard the hypothesis that COMT haplotypes do not influence non-recovery or pain levels in patients with acute whiplash injuries. High levels of initial pain and anxiety were associated with non-recovery, thereby confirming previously published reports. [ABSTRACT FROM AUTHOR]

Published
2017
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48. Mapping human brain monoamine oxidase A and B with carbon eleven-labeled suicide inactivators and PET

Author

Fowler, J.S., MacGregor, R.R., Wolf, A.P., Arnett, C.D., Dewey, S.L., Schlyer, D., Christman, D., Logan, J., Smith, M., Sachs, H., Aquilonius, S.M., Bjurling, P., Halldin, C., Hartvig, P., Leenders, K.L., Lundquist, H., Oreland, L., Stalnacke, C.-G., and Langstrom, B.

Subjects
Usage, Research, Synaptic transmission -- Research -- Usage, Monoamine oxidase -- Usage -- Research, Parkinsonism -- Research, Brain research -- Usage -- Research, Neural transmission -- Research -- Usage
Abstract

Mapping Human Brain Monoamine Oxidase A and B with 11C-Labeled Suicide Inactivators and PET MONOAMINE OXIDASE (MAO)(E.C. 1.4.3.4) is responsible for the oxidative deamination of endogenous neurotransmitter amines as well [...]

Published
1987

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