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The article presents the assessment and results of researching of prospects of development of the Russian oilfield services market and Russian oilfield services companies. The analysis of the needs of the oil and gas sector in oilfield services is made. The authors consider the structure and volume of Russian market of services in oil and gas industry. Within the scope of this article the authors highlight the main problems of the oil service industry in Russia.

The application of public-private partnership to stimulate the socio-economic development of the Arctic zone are considered. The importance of this task is determined by the fact that the reserves of natural resources located in the Arctic should provide the basis for the energy and economic security of the country. The comparative analysis of ways of realization of infrastructure projects on the basis of the state order and public - private partnership is carried out. The aspects of the influence of public-private partnership on the development of the region and increase its investment potential are discussed.

The article presents the results of studying the formation, the current state and prospects for the development of public-private partnership (PPP) in the fuel and energy sector in Russia. The authors consider the existing mechanisms of interaction between the public and private parties in the projects of the fuel and energy complex, including so-called quasi-PPP projects, i.e. relevant PPP on economic content. Such projects include production sharing agreements, special investment contracts, etc. Within the framework of the article, the authors highlight the main problems of the functioning of public-private partnership instruments and consider trends in the use of PPPs for the development of the fuel and energy complex in Russia

The article presents the assessment and results of researching of prospects of development of the Russian oilfield services market and Russian oilfield services companies. The analysis of the needs of the oil and gas sector in oilfield services is made. The authors consider the structure and volume of Russian market of services in oil and gas industry. Within the scope of this article the authors highlight the main problems of the oil service industry in Russia.

The issue of providing reliable, safe and at the same time least invasive venous access remains one of the topical issues of oncology. Installation of venous access for patients with oncological pathology is necessary for chemotherapy, blood sampling for analysis, as well as for palliative and symptomatic care for patients which has advanced stages of malignant process. Therapeutic agents can be administered in various ways: intra-arterially, intravenously, intraperitoneally. In the world of modern medicine, intravenous administration of drugs is most often used, since it provides a high rate of spread, as well as systemic action in the human body. However, not all medicinal substances are amenable to easy and safe delivery by parenteral route and, first of all, it concerns cytostatic agents. Chemotherapy has an irritating and sometimes damaging effect on the walls of peripheral vessels, and frequent blood fetuses and the introduction of parenteral chemotherapeutic agents entail complications in the form of phlebitis, thrombophlebitis and other septic processes that can lead to death. Despite the fact that the port system was invented more than 50 years ago, this device is increasingly used in the daily clinical practice of an oncologist and doctors of other specialties, including anesthesiology and pediatrics. So the port system is a small device which is placed under the skin under local anesthesia to perform certain medical manipulations related to the treatment and diagnosis of diseases. This article provides arguments on the appropriateness of using the subcutaneous venous port system, its advantages, disadvantages, as well as the features of its installation, exploitation and also their importance in the modern clinical medicine.

The Russian Federation is among countries with high cardiovascular risk. Hypercholesterolemia is a leading risk factor for the development of atherosclerotic cardiovascular diseases. To achieve low-density lipoprotein cholesterol (LDL-C) targets, such approaches as lifestyle changes and pharmacological correction, based on the use of statins, are applied. At the same time, a significant proportion of the population has moderate hypercholesterolemia and is characterized by low or moderate cardiovascular risk. Although first-line recommendations should be followed, a healthy lifestyle alone is not enough to achieve target levels of LDL-C, which means that even people with low to moderate risk may end up with the prospect of lifelong therapy with lipid-lowering drugs. These individuals do not have an indication for lipid-lowering therapy, and they are usually recommended a change in diet and supplementation. Innovative nutritional strategies have been developed to manage dyslipidemia. They were based either on changing some “risky” food components or on encouraging the consumption of “healthy” functional foods and/or nutraceuticals. Nutraceuticals (registered as food supplements in Russia) is an innovative way to help control LDL-C at low and moderate risk individuals without lipid-lowering drugs and as nutritive support for the cholesterol-lowering diet. Red yeast rice (RYR) based preparations have been already developed and available at the moment. RYR based preparations can be considered in patients with low and moderate cardiovascular risk, who have not reached the target level of LDL-C and have no indications for statin therapy or have statin intolerance. RYR based preparations contains a statin-like substance monacolin K in a dose of 3 mg. In randomized clinical trials, it was proved that the use of high-quality RYR nutraceutical leads to a decrease in LDL-C by an average of 20% without increasing the risk of side effects like for statins. Evaluation of dietary supplements and functional foods should necessarily include not only evidence of beneficial effects with respect to effects on the lipid profile and atherosclerosis, but also proven good tolerability. The manufacturing standard for these products is also important, guaranteeing component standardization and quality. RYR analogues should guarantee the absence of mycotoxin in their composition. In Russia, programs are needed for the primary prevention of atherosclerotic cardiovascular diseases with effects on hypercholesterolemia at the population level.

Carbon nanoparticles with antimicrobial properties, such as fullerenes, can be distinguished among the promising means of combating pathogens characterized by resistance to commercial antibiotics. However, they have a number of limitations for their use in medicine. In particular, the insolubility of carbon nanoparticles in water leads to a low biocompatibility and especially strong aggregation when transferred to liquid media. To overcome the negative factors and enhance the action of fullerenes in an extended range of applications, for example, in antimicrobial photodynamic therapy, we created new water-soluble complexes containing, in addition to C60 fullerene, purified detonation nanodiamonds (AC960) and/or polyvinylpyrrolidone (PVP). The in vitro antibacterial activity and toxicity to human cells of the three-component complex C60+AC960+PVP were analyzed in comparison with binary C60+PVP and C60+AC960. All complexes showed a low toxicity to cultured human skin fibroblasts and ECV lines, as well as significant antimicrobial activity, which depend on the type of microorganisms exposed, the chemical composition of the complex, its dosage and exposure time. Complex C60+PVP+AC960 at a concentration of 175 µg/mL showed the most stable and pronounced inhibitory microbicidal/microbiostatic effect.

Abstract: Voltage-gated Ca2+ channels play a key role in the regulation of arterial tone and blood pressure. The aim of this study was to determine whether the association of calcium voltage-gated channel subunit alpha1 C (CACNA1C) rs1006737 with essential hypertension (EH) exists in both Chinese Han and ethnic Russian populations of Northeast Asia. We used a case-control study of 2 ethnic groups in the same latitude geographical area to investigate the association between the susceptibility of EH and rs1006737 polymorphism. A total of 1512 EH patients and 1690 controls in Chinese Han people (Heilongjiang Provence, China), 250 EH patients, and 250 controls in ethnic Russian people (Chita, Russia), participated in this study. All participants were genotyped using the TaqMan SNP genotyping assay (Agena Company). Baseline characteristics and the minor allele frequencies of rs1006737 vary substantially among common Chinese Han and ethnic Russian people. Allele A was found to be a risk factor for EH in Chinese Han [(odds ratio) OR 1.705, (confidence interval) 95% CI: 1.332-2.182, P < .001] and ethnic Russian (OR 1.437; 95% CI: 1.110-1.860, P = .006). The GA genotype was significantly associated with an increased risk of hypertension (OR 1.538, 95% CI: 1.188-1.991, P = .001) for Chinese Han people, and the AA genotype (OR 2.412, 95% CI: 1.348-4.318, P = .003) for ethnic Russian people. The results of this study indicate that the A allele of the variant rs1006737 in the CACNA1C gene may be a useful genetic marker for EH risk prediction in Chinese Han and ethnic Russian populations., Competing Interests: The authors report no conflicts of interest., (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)

Neuroprotective properties of fullerenols С 60 (OH) 30 and С 70 (OH) 30 have been shown in a Drosophila melanogaster model of Parkinson's Disease (PD). Fullerenols used in this work demonstrated negligible toxicity even at high concentrations as a result of a specifically developed manufacturing process. It has been shown that the drugs promote restoration of dopamine levels, reduce oxidative stress in transgenic flies expressing the human alpha-synuclein gene, prevent death of dopaminergic neurons in the brain and alleviate aggregation of alpha-synuclein. Thus, the anti-aggregation effect of fullerenols, demonstrated for various forms of amyloid proteins, is also observed for alpha-synuclein, resulting in reduction of formation of insoluble aggregates of this protein. Neuroprotective activity was affected by the Drosophila melanogaster genotype and not by the number of carbon atoms in the fullerenol compounds. We concluded that due to their unique properties, fullerenols might be a promising tool for drug development to treat PD., (Copyright © 2019 Elsevier Inc. All rights reserved.)

The toxicity of C 60 (OH) 30 , C 70 (OH) 30 , and C 120 O(OH) n fullerenols, prepared by a new original method, has been studied. This method allowed us to obtain high-purity fullerenols and eliminate the risks of synthesis of preparations containing insoluble fractions contaminated with impurities such as fullerenes not completely reacted by hydroxylation. All fullerenols were detected inside cultured cells. The MTT assay as well as the analysis of apoptosis and cell cycle showed that С 60 (ОН) 30 and С 70 (OH) 30 are non-toxic for cultured V79 и HeLa cells at concentrations exceeding physiological levels by an order of magnitude. С 120 O(OH) n caused low toxicity. Studies in Drosophila melanogaster showed that any preparations used did not result in a decreased lifespan or in behavior abnormalities in flies., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Background: Mutations of the amyloid precursor protein gene (APP) are found in familial forms of Alzheimer's disease (AD) and some lead to the elevated production of amyloid-beta-protein (Abeta). While Abeta has been implicated in the causation of AD, the exact role played by Abeta and its APP precursor are still unclear., Principal Findings: In our study, Drosophila melanogaster transgenics were established as a model to analyze AD-like pathology caused by APP overexpression. We demonstrated that age related changes in the levels and pattern of synaptic proteins accompanied progressive neurodegeneration and impairment of cognitive functions in APP transgenic flies, but that these changes may be independent from the generation of Abeta. Using novel peptide mimetics of Apolipoprotein-E, COG112 or COG133 proved to be neuroprotective and significantly improved the learning and memory of APP transgenic flies., Conclusions: The development of neurodegeneration and cognitive deficits was corrected by injections of COG112 or COG133, novel mimetics of apolipoprotein-E (apoE) with neuroprotective activities.