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1. Exploring participant’s experiences in a multifamily therapy group on schizophrenia : a qualitative approach

Author

O. Amiot, C. Genis, L. Champlon, S. Said, and L. Baziret

Subjects
Psychiatry, RC435-571
Abstract

Introduction Prevention of relapse in schizophrenia is a major public health issue. A recent network meta-analysis investigating interventions for relapse prevention in schizophrenia found that the efficacity of family psychoeducation and systemic integrated interventions were superior to treatment as usual at 12 months (Bighelli I, Leucht S et al. Lancet Psychiatry 2021). Other studies also found that multi-family therapies (MFT) were superior to treatment as usual and family psychoeducation in preventing relapses at 2 and 4 years (McFarlane WR, Lukens EP et al. Archives of General Psychiatry.1995). Considering this, we developped in our community center an MFT program based on systemic approach and psychoeducation. Objectives Investigate the subjective experience of participants of an MFT group focusing on schizophrenia. Methods A qualitative study was designed to explore personal experience of participants using the Interpretative Phenomenological Analysis (IPA) method in order to analyse participant’s feedback during semi-directive interviews. By using IPA, participants are experts of their experience. Eight participants took part in this study: 4 patients and 4 parents. Results Within all participant’s feedback around 10 different themes emerged. We identified three major themes which we have described as: “Affiliation to the group”, “Framework of Discovery”, “Benefits of MFT”. According to “Affiliation to the group”, all participants report movements of adhesion or rejection towards the group. This theme has been subdivided into two sub-themes: “Temporality”, and “Identification/differentiation”. These sub-themes revealed inter-individuals’ differences. According to “Framework of discovery”, the MFT group has been identified as a secure place allowing self and other’s discovery place. This theme has been divided into two sub-themes: “discovering skills” and “improving oneself and relatives’ understanding”. Participants experience taking a step back and decentering oneself from usual personnal position. According to “Benefits of MFT”, participants report the feeling of belonging to a group, the impact on self-esteem, on mentalization skills, and on the reflexion on family members’ experience of the disease. Conclusions This study is, to our knowledge, the first qualitative study examining the subjective experience of members who participated in a psychoeducational and systemic MFT group focusing on schizophrenia. It provides insight into the families’ experience, both from the patient’s and from each family member’s perspective. Results highlight that participants seized the MFT group as a learning space at several levels: personal, intra-family and inter-family. These data could enlighten professionals working with families on the potential apprehensions of participants, their representations of the group and what process MFT could initiate. Disclosure of Interest None Declared

Published
2024
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2. Who benefits from multifamily psychoeducation groups ? Descriptive anaysis of participants

Author

O. Amiot, C. Genis, L. Baziret, L. Champlon, and S. Saïd

Subjects
Psychiatry, RC435-571
Abstract

Introduction Guidelines for relapse prevention in schizophrenia recommend psychoeducation for patients and caregivers (Bighelli I, Leucht S et al. Lancet Psychiatry 2021). Considering that, in 2021, we implemented in our Psychiatric community center a multifamily therapy (MFT). The program is based on systemic approach and psychoeducation, focusing on schizophrenia. Objectives Describe participants of MFT groups focusing on schizophrenia. * Patients’ characteristics : age, gender, duration of psychiatric follow-up, history of hospitalization * Caregivers’ characterics: status, age. Methods We carried out a descriptive study of the different profile of MFT groups participants in our community center from 2021 to today. Results Since 2021, 4 MFT groups took place including 50 participants: 18 patients suffering from schizophrenia and 32 relatives. Image 1 illustrates the different participants of each group. Each group was different. Some patients came with both their parents, even if divorced, some came only with their mother. Some came with a sibling. Nevertheless, the numbers of fathers and siblings did not always allow us to work in sub-groups. Considering patients: 18 patients benefited from our program. 8 female and 10 male patients (55.6%) were admitted and distributed in each group as described in image 2. The mean age of patients was 31.9 years old [20.1 – 57.5]. Each group was made up of patients with psychiatric follow-up ranging from 1 year to more than 20 years, and having experienced between 1 to more than 5 psychiatric hospitalizations. It appears that Group 4 was noticeably younger than the other groups with a mean age of 22.4 years old [20.4 – 26.7] and a shorter history in psychiatry with less hospitalisations (image 3). Considering relatives: 15 mothers, 9 fathers, 5 siblings, 1 spouse, 1 aunt and 1 uncle benefited from psychoeducation to caregivers. The relatives were from 47 to 81 years old for the parents, and from 17 to 50,7 for the siblings. Unlike parents, siblings generally attended a limited number of sessions. Image: Image 2: Image 3: Conclusions This descriptive study reflects the work carried out with 18 patients and their relatives in an MFT group providing psychoeducation to patients suffering from schizophrenia and their caregivers. 50 persons benefited from psychoeducation in 2 years. We learned from these results to improve the constitution of our groups and the benefits of our psychoeducation program. We were careful to include families with siblings as we know they are affected by the mental illness in the family and are often left aside of all care/support proposals. We questioned ourselves on the advantages of homogeneous or heterogeneous groups, considering age, history of follow up. How could it impact affiliation to the group or differentiation movements ? How useful or harmful it is for sharing experiences between the families. A proper study would be necessary to answer these questions. Disclosure of Interest None Declared

Published
2024
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3. Deprexis® Acceptability study in REal life (DARE): study design

Author

O. Amiot, A. H. Clair, P. Courtet, E. Fakra, V. Narboni, F. Gheysen, E. Haffen, D. Drapier, and L. Lecardeur

Subjects
Psychiatry, RC435-571
Abstract

Introduction Depression is a leading cause of disability, worldwide. Recently, WHO highlighted the negative impact of recent crises (COVID-19 pandemic, war in Ukraine, economic crisis). Although most international guidelines recommend psychotherapies as first-line treatment of depression, access remains scarce in France due to limited availability of trained clinicians (notably those with CBT certification), high cost for patient in a context of non-reimbursement and fear of stigmatization (Coldefy M. HCAA, 2022/04,19). Therefore, online blended psychological treatment such as deprexis® could increase access to care for people with depression. It presents several advantages such as easy access, scalability, and a proven efficacy (Twomey et al. PLoS One. 2020;15(1):e022810). Objectives This study aims to test real-life acceptability of deprexis® for people with depression in France outside a reimbursement pathway. Primary objective of this cross-sectional study is to measure acceptability of deprexis® a new digital therapy in France. Questionnaire includes acceptability of deprexis® assessed with patient willingness to complete deprexis® course, reasons of refusal, when needed, demographics and depression characteristics. The secondary objectives are to study 1/ acceptability according to type of center (Hospital based, Community Based or private practice) and type of practitioners (psychiatrists or psychologists), 2/ differences in acceptability according to severity’s level (evaluated with PHQ 9), 3/ differences in acceptability according to administration or not of a treatment (including psychotherapy), 4/ differences in acceptability according to prescriber’s profile (age, sex, place and type of practice), 5/ identification of reasons for refusal , and 6/ analyze refusal rate over time. Methods DARE is as a cross-sectional study in which deprexis® is suggested to any patient meeting the inclusion criteria over the fixed inclusion period June-December 2022 Inclusion criteria are: 1/ depression, 2/ age between 18 and 65 years, 3/ speak French sufficiently, 4/ access to Internet with a device to connect to deprexis® platform. Exclusion criteria are diagnosis of bipolar disorder, psychotic symptoms and/or suicidal thoughts during the current episode. All investigators received a video-based training on deprexis® before inclusion to make sure they all have same level of information and understanding on the program. Results The study is currently recruiting. Data will be available for EPA congress. Conclusions It is a first time a digital therapy is completing the current therapeutic options for the treatment of depression in France. Acceptability of this innovation by both patients and Healthcare providers is a first step. DARE may allow to have a better understanding of the acceptability of a digital therapy in the treatment of depression in France and identify the different factors influencing it in a natural setting. Disclosure of Interest O. Amiot Consultant of: Ethypharm Digital Therapy, A. H. Clair Consultant of: Ethypharm Digital Therapy, P. Courtet Consultant of: Ethypharm Digital Therapy, E. Fakra Consultant of: Ethypharm Digital Therapy, V. Narboni Employee of: Ethypharm Digital Therapy, F. Gheysen Consultant of: Ethypharm Digital Therapy, E. Haffen Consultant of: Ethypharm Digital Therapy, D. Drapier Consultant of: Ethypharm Digital Therapy, L. Lecardeur Consultant of: Ethypharm Digital Therapy

Published
2023
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4. Sudden cardiac death prevention in the era of novel heart failure medications

Author

I. Koev, M. Yarkoni, D. Luria, O. Amir, and Y. Biton

Subjects
Sudden cardiac death, Heart failure with reduced ejection fraction, ICD, Therapy, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Sudden cardiac death (SCD) occurs unexpectedly and is usually a result of ventricular arrhythmia in patients with structural heart disease. The implantable cardioverter-defibrillator (ICD), with or without biventricular pacing, has been proven to be protective for heart failure patients with reduced ejection fraction of

Published
2023
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5. The ATLAS Inner Detector commissioning and calibration

Author

The ATLAS Collaboration Aad, G. Abbott, B. Abdallah, J. Abdelalim, A.A. Abdesselam, A. Abdinov, O. Abi, B. Abolins, M. Abramowicz, H. Abreu, H. Acharya, B.S. Adams, D.L. Addy, T.N. Adelman, J. Adorisio, C. Adragna, P. Adye, T. Aefsky, S. Aguilar-Saavedra, J.A. Aharrouche, M. Ahlen, S.P. Ahles, F. Ahmad, A. Ahsan, M. Aielli, G. Akdogan, T. Åkesson, T.P.A. Akimoto, G. Akimov, A.V. Aktas, A. Alam, M.S. Alam, M.A. Albrand, S. Aleksa, M. Aleksandrov, I.N. Alexa, C. Alexander, G. Alexandre, G. Alexopoulos, T. Alhroob, M. Aliev, M. Alimonti, G. Alison, J. Aliyev, M. Allport, P.P. Allwood-Spiers, S.E. Almond, J. Aloisio, A. Alon, R. Alonso, A. Alviggi, M.G. Amako, K. Amelung, C. Amorim, A. Amorós, G. Amram, N. Anastopoulos, C. Andeen, T. Anders, C.F. Anderson, K.J. Andreazza, A. Andrei, V. Anduaga, X.S. Angerami, A. Anghinolfi, F. Anjos, N. Annovi, A. Antonaki, A. Antonelli, M. Antonelli, S. Antos, J. Antunovic, B. Anulli, F. Aoun, S. Arabidze, G. Aracena, I. Arai, Y. Arce, A.T.H. Archambault, J.P. Arfaoui, S. Arguin, J.-F. Argyropoulos, T. Arik, M. Armbruster, A.J. Arnaez, O. Arnault, C. Artamonov, A. Arutinov, D. Asai, M. Asai, S. Asfandiyarov, R. Ask, S. Åsman, B. Asner, D. Asquith, L. Assamagan, K. Astvatsatourov, A. Atoian, G. Auerbach, B. Augsten, K. Aurousseau, M. Austin, N. Avolio, G. Avramidou, R. Ay, C. Azuelos, G. Azuma, Y. Baak, M.A. Bach, A.M. Bachacou, H. Bachas, K. Backes, M. Badescu, E. Bagnaia, P. Bai, Y. Bain, T. Baines, J.T. Baker, O.K. Baker, M.D. Baker, S. Dos Pedrosa, F.B.S. Banas, E. Banerjee, P. Banerjee, S. Banfi, D. Bangert, A. Bansal, V. Baranov, S.P. Barashkou, A. Barber, T. Barberio, E.L. Barberis, D. Barbero, M. Bardin, D.Y. Barillari, T. Barisonzi, M. Barklow, T. Barlow, N. Barnett, B.M. Barnett, R.M. Baroncelli, A. Barr, A.J. Barreiro, F. Guimarães da Costa, J.B. Barrillon, P. Bartoldus, R. Bartsch, D. Bates, R.L. Batkova, L. Batley, J.R. Battaglia, A. Battistin, M. Bauer, F. Bawa, H.S. Bazalova, M. Beare, B. Beau, T. Beauchemin, P.H. Beccherle, R. Bechtle, P. Beck, G.A. Beck, H.P. Beckingham, M. Becks, K.H. Beddall, A.J. Beddall, A. Bednyakov, V.A. Bee, C. Begel, M. Harpaz, S.B. Behera, P.K. Beimforde, M. Belanger-Champagne, C. Bell, P.J. Bell, W.H. Bella, G. Bellagamba, L. Bellina, F. Bellomo, M. Belloni, A. Belotskiy, K. Beltramello, O. Ami, S.B. Benary, O. Benchekroun, D. Bendel, M. Benedict, B.H. Benekos, N. Benhammou, Y. Benjamin, D.P. Benoit, M. Bensinger, J.R. Benslama, K. Bentvelsen, S. Beretta, M. Berge, D. Kuutmann, E.B. Berger, N. Berghaus, F. Berglund, E. Beringer, J. Bernabéu, J. Bernat, P. Bernhard, R. Bernius, C. Berry, T. Bertin, A. Besana, M.I. Besson, N. Bethke, S. Bianchi, R.M. Bianco, M. Biebel, O. Biesiada, J. Biglietti, M. Bilokon, H. Bindi, M. Bingul, A. Bini, C. Biscarat, C. Bitenc, U. Black, K.M. Blair, R.E. Blanchard, J.-B. Blanchot, G. Blocker, C. Blondel, A. Blum, W. Blumenschein, U. Bobbink, G.J. Bocci, A. Boehler, M. Boek, J. Boelaert, N. Böser, S. Bogaerts, J.A. Bogouch, A. Bohm, C. Bohm, J. Boisvert, V. Bold, T. Boldea, V. Bondarenko, V.G. Bondioli, M. Boonekamp, M. Bordoni, S. Borer, C. Borisov, A. Borissov, G. Borjanovic, I. Borroni, S. Bos, K. Boscherini, D. Bosman, M. Boterenbrood, H. Bouchami, J. Boudreau, J. Bouhova-Thacker, E.V. Boulahouache, C. Bourdarios, C. Boveia, A. Boyd, J. Boyko, I.R. Bozovic-Jelisavcic, I. Bracinik, J. Braem, A. Branchini, P. Brandt, A. Brandt, G. Brandt, O. Bratzler, U. Brau, B. Brau, J.E. Braun, H.M. Brelier, B. Bremer, J. Brenner, R. Bressler, S. Britton, D. Brochu, F.M. Brock, I. Brock, R. Brodet, E. Bromberg, C. Brooijmans, G. Brooks, W.K. Brown, G. Bruckman de Renstrom, P.A. Bruncko, D. Bruneliere, R. Brunet, S. Bruni, A. Bruni, G. Bruschi, M. Bucci, F. Buchanan, J. Buchholz, P. Buckley, A.G. Budagov, I.A. Budick, B. Büscher, V. Bugge, L. Bulekov, O. Bunse, M. Buran, T. Burckhart, H. Burdin, S. Burgess, T. Burke, S. Busato, E. Bussey, P. Buszello, C.P. Butin, F. Butler, B. Butler, J.M. Buttar, C.M. Butterworth, J.M. Byatt, T. Caballero, J. Cabrera Urbán, S. Caforio, D. Cakir, O. Calafiura, P. Calderini, G. Calfayan, P. Calkins, R. Caloba, L.P. Calvet, D. Camarri, P. Cameron, D. Campana, S. Campanelli, M. Canale, V. Canelli, F. Canepa, A. Cantero, J. Capasso, L. Garrido, M.D.M.C. Caprini, I. Caprini, M. Capua, M. Caputo, R. Caramarcu, C. Cardarelli, R. Carli, T. Carlino, G. Carminati, L. Caron, B. Caron, S. Montoya, G.D.C. Montero, S.C. Carter, A.A. Carter, J.R. Carvalho, J. Casadei, D. Casado, M.P. Cascella, M. Castaneda Hernandez, A.M. Castaneda-Miranda, E. Gimenez, V.C. Castro, N.F. Cataldi, G. Catinaccio, A. Catmore, J.R. Cattai, A. Cattani, G. Caughron, S. Cavalleri, P. Cavalli, D. Cavalli-Sforza, M. Cavasinni, V. Ceradini, F. Cerqueira, A.S. Cerri, A. Cerrito, L. Cerutti, F. Cetin, S.A. Chafaq, A. Chakraborty, D. Chan, K. Chapman, J.D. Chapman, J.W. Chareyre, E. Charlton, D.G. Chavda, V. Cheatham, S. Chekanov, S. Chekulaev, S.V. Chelkov, G.A. Chen, H. Chen, S. Chen, X. Cheplakov, A. Chepurnov, V.F. Cherkaoui El Moursli, R. Tcherniatine, V. Chesneanu, D. Cheu, E. Cheung, S.L. Chevalier, L. Chevallier, F. Chiefari, G. Chikovani, L. Childers, J.T. Chilingarov, A. Chiodini, G. Chizhov, V. Choudalakis, G. Chouridou, S. Christidi, I.A. Christov, A. Chromek-Burckhart, D. Chu, M.L. Chudoba, J. Ciapetti, G. Ciftci, A.K. Ciftci, R. Cinca, D. Cindro, V. Ciobotaru, M.D. Ciocca, C. Ciocio, A. Cirilli, M. Clark, A. Clark, P.J. Cleland, W. Clemens, J.C. Clement, B. Clement, C. Coadou, Y. Cobal, M. Coccaro, A. Cochran, J. Coggeshall, J. Cogneras, E. Colijn, A.P. Collard, C. Collins, N.J. Collins-Tooth, C. Collot, J. Colon, G. Conde Muiño, P. Coniavitis, E. Conidi, M.C. Consonni, M. Constantinescu, S. Conta, C. Conventi, F. Cooke, M. Cooper, B.D. Cooper-Sarkar, A.M. Cooper-Smith, N.J. Copic, K. Cornelissen, T. Corradi, M. Corriveau, F. Corso-Radu, A. Cortes-Gonzalez, A. Cortiana, G. Costa, G. Costa, M.J. Costanzo, D. Costin, T. Côté, D. Torres, R.C. Courneyea, L. Cowan, G. Cowden, C. Cox, B.E. Cranmer, K. Cranshaw, J. Cristinziani, M. Crosetti, G. Crupi, R. Crépé-Renaudin, S. Almenar, C.C. Donszelmann, T.C. Curatolo, M. Curtis, C.J. Cwetanski, P. Czyczula, Z. D'Auria, S. D'Onofrio, M. D'Orazio, A. Da Via, C. Dabrowski, W. Dai, T. Dallapiccola, C. Dallison, S.J. Daly, C.H. Dam, M. Danielsson, H.O. Dannheim, D. Dao, V. Darbo, G. Darlea, G.L. Davey, W. Davidek, T. Davidson, N. Davidson, R. Davies, M. Davison, A.R. Dawson, I. Daya, R.K. De, K. de Asmundis, R. De Castro, S. De Faria Salgado, P.E.C. De Cecco, S. de Graat, J. De Groot, N. de Jong, P. De Mora, L. De Branco, M.O. De Pedis, D. De Salvo, A. De Sanctis, U. De Santo, A. De Vivie De Regie, J.B. Dean, S. Dedovich, D.V. Degenhardt, J. Dehchar, M. Del Papa, C. Del Peso, J. Del Prete, T. Dell'Acqua, A. Dell'Asta, L. Della Pietra, M. della Volpe, D. Delmastro, M. Delsart, P.A. Deluca, C. Demers, S. Demichev, M. Demirkoz, B. Deng, J. Deng, W. Denisov, S.P. Derkaoui, J.E. Derue, F. Dervan, P. Desch, K. Deviveiros, P.O. Dewhurst, A. DeWilde, B. Dhaliwal, S. Dhullipudi, R. Di Ciaccio, A. Di Ciaccio, L. Di Girolamo, A. Di Girolamo, B. Di Luise, S. Di Mattia, A. Di Nardo, R. Di Simone, A. Di Sipio, R. Diaz, M.A. Diblen, F. Diehl, E.B. Dietrich, J. Dietzsch, T.A. Diglio, S. Yagci, K.D. Dingfelder, J. Dionisi, C. Dita, P. Dita, S. Dittus, F. Djama, F. Djilkibaev, R. Djobava, T. do Vale, M.A.B. Do Wemans, A.V. Doan, T.K.O. Dobos, D. Dobson, E. Dobson, M. Doglioni, C. Doherty, T. Dolejsi, J. Dolenc, I. Dolezal, Z. Dolgoshein, B.A. Dohmae, T. Donega, M. Donini, J. Dopke, J. Doria, A. Dos Anjos, A. Dotti, A. Dova, M.T. Doxiadis, A. Doyle, A.T. Drasal, Z. Dris, M. Dubbert, J. Duchovni, E. Duckeck, G. Dudarev, A. Dudziak, F. Dührssen, M. Duflot, L. Dufour, M.-A. Dunford, M. Yildiz, H.D. Duxfield, R. Dwuznik, M. Düren, M. Ebenstein, W.L. Ebke, J. Eckweiler, S. Edmonds, K. Edwards, C.A. Egorov, K. Ehrenfeld, W. Ehrich, T. Eifert, T. Eigen, G. Einsweiler, K. Eisenhandler, E. Ekelof, T. El Kacimi, M. Ellert, M. Elles, S. Ellinghaus, F. Ellis, K. Ellis, N. Elmsheuser, J. Elsing, M. Emeliyanov, D. Engelmann, R. Engl, A. Epp, B. Eppig, A. Erdmann, J. Ereditato, A. Eriksson, D. Ermoline, I. Ernst, J. Ernst, M. Ernwein, J. Errede, D. Errede, S. Ertel, E. Escalier, M. Escobar, C. Curull, X.E. Esposito, B. Etienvre, A.I. Etzion, E. Evans, H. Fabbri, L. Fabre, C. Facius, K. Fakhrutdinov, R.M. Falciano, S. Fang, Y. Fanti, M. Farbin, A. Farilla, A. Farley, J. Farooque, T. Farrington, S.M. Farthouat, P. Fassnacht, P. Fassouliotis, D. Fatholahzadeh, B. Fayard, L. Fayette, F. Febbraro, R. Federic, P. Fedin, O.L. Fedorko, W. Feligioni, L. Felzmann, C.U. Feng, C. Feng, E.J. Fenyuk, A.B. Ferencei, J. Ferland, J. Fernandes, B. Fernando, W. Ferrag, S. Ferrando, J. Ferrara, V. Ferrari, A. Ferrari, P. Ferrari, R. Ferrer, A. Ferrer, M.L. Ferrere, D. Ferretti, C. Fiascaris, M. Fiedler, F. Filipčič, A. Filippas, A. Filthaut, F. Fincke-Keeler, M. Fiolhais, M.C.N. Fiorini, L. Firan, A. Fischer, G. Fisher, M.J. Flechl, M. Fleck, I. Fleckner, J. Fleischmann, P. Fleischmann, S. Flick, T. Castillo, L.R.F. Flowerdew, M.J. Martin, T.F. Formica, A. Forti, A. Fortin, D. Fournier, D. Fowler, A.J. Fowler, K. Fox, H. Francavilla, P. Franchino, S. Francis, D. Franklin, M. Franz, S. Fraternali, M. Fratina, S. Freestone, J. French, S.T. Froeschl, R. Froidevaux, D. Frost, J.A. Fukunaga, C. Torregrosa, E.F. Fuster, J. Gabaldon, C. Gabizon, O. Gadfort, T. Gadomski, S. Gagliardi, G. Gagnon, P. Galea, C. Gallas, E.J. Gallo, V. Gallop, B.J. Gallus, P. Galyaev, E. Gan, K.K. Gao, Y.S. Gaponenko, A. Garcia-Sciveres, M. García, C. Navarro, J.E.G. Gardner, R.W. Garelli, N. Garitaonandia, H. Garonne, V. Gatti, C. Gaudio, G. Gautard, V. Gauzzi, P. Gavrilenko, I.L. Gay, C. Gaycken, G. Gazis, E.N. Ge, P. Gee, C.N.P. Geich-Gimbel, C. Gellerstedt, K. Gemme, C. Genest, M.H. Gentile, S. Georgatos, F. George, S. Gershon, A. Ghazlane, H. Ghodbane, N. Giacobbe, B. Giagu, S. Giakoumopoulou, V. Giangiobbe, V. Gianotti, F. Gibbard, B. Gibson, A. Gibson, S.M. Gilbert, L.M. Gilchriese, M. Gilewsky, V. Gingrich, D.M. Ginzburg, J. Giokaris, N. Giordani, M.P. Giordano, R. Giorgi, F.M. Giovannini, P. Giraud, P.F. Girtler, P. Giugni, D. Giusti, P. Gjelsten, B.K. Gladilin, L.K. Glasman, C. Glazov, A. Glitza, K.W. Glonti, G.L. Godfrey, J. Godlewski, J. Goebel, M. Göpfert, T. Goeringer, C. Gössling, C. Göttfert, T. Goggi, V. Goldfarb, S. Goldin, D. Golling, T. Gomes, A. Fajardo, L.S.G. Gonçalo, R. Gonella, L. Gong, C. González de la Hoz, S. Silva, M.L.G. Gonzalez-Sevilla, S. Goodson, J.J. Goossens, L. Gordon, H.A. Gorelov, I. Gorfine, G. Gorini, B. Gorini, E. Gorišek, A. Gornicki, E. Gosdzik, B. Gosselink, M. Gostkin, M.I. Eschrich, I.G. Gouighri, M. Goujdami, D. Goulette, M.P. Goussiou, A.G. Goy, C. Grabowska-Bold, I. Grafström, P. Grahn, K.-J. Grancagnolo, S. Grassi, V. Gratchev, V. Grau, N. Gray, H.M. Gray, J.A. Graziani, E. Green, B. Greenshaw, T. Greenwood, Z.D. Gregor, I.M. Grenier, P. Griesmayer, E. Griffiths, J. Grigalashvili, N. Grillo, A.A. Grimm, K. Grinstein, S. Grishkevich, Y.V. Groh, M. Groll, M. Gross, E. Grosse-Knetter, J. Groth-Jensen, J. Grybel, K. Guicheney, C. Guida, A. Guillemin, T. Guler, H. Gunther, J. Guo, B. Gusakov, Y. Gutierrez, A. Gutierrez, P. Guttman, N. Gutzwiller, O. Guyot, C. Gwenlan, C. Gwilliam, C.B. Haas, A. Haas, S. Haber, C. Hadavand, H.K. Hadley, D.R. Haefner, P. Hajduk, Z. Hakobyan, H. Haller, J. Hamacher, K. Hamilton, A. Hamilton, S. Han, L. Hanagaki, K. Hance, M. Handel, C. Hanke, P. Hansen, J.R. Hansen, J.B. Hansen, J.D. Hansen, P.H. Hansl-Kozanecka, T. Hansson, P. Hara, K. Hare, G.A. Harenberg, T. Harrington, R.D. Harris, O.M. Harrison, K. Hartert, J. Hartjes, F. Harvey, A. Hasegawa, S. Hasegawa, Y. Hassani, S. Haug, S. Hauschild, M. Hauser, R. Havranek, M. Hawkes, C.M. Hawkings, R.J. Hayakawa, T. Hayward, H.S. Haywood, S.J. Head, S.J. Hedberg, V. Heelan, L. Heim, S. Heinemann, B. Heisterkamp, S. Helary, L. 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Robinson, M. Robson, A. Rocha de Lima, J.G. Roda, C. Dos Santos, D.R. Rodriguez, D. Garcia, Y.R. Roe, S. Røhne, O. Rojo, V. Rolli, S. Romaniouk, A. Romanov, V.M. Romeo, G. Maltrana, D.R. Roos, L. Ros, E. Rosati, S. Rosenbaum, G.A. Rosselet, L. Rossetti, V. Rossi, L.P. Rotaru, M. Rothberg, J. Rousseau, D. Royon, C.R. Rozanov, A. Rozen, Y. Ruan, X. Ruckert, B. Ruckstuhl, N. Rud, V.I. Rudolph, G. Rühr, F. Ruggieri, F. Ruiz-Martinez, A. Rumyantsev, L. Rurikova, Z. Rusakovich, N.A. Rutherfoord, J.P. Ruwiedel, C. Ruzicka, P. Ryabov, Y.F. Ryan, P. Rybkin, G. Rzaeva, S. Saavedra, A.F. Sadrozinski, H.F.-W. Sadykov, R. Tehrani, F.S. Sakamoto, H. Salamanna, G. Salamon, A. Saleem, M.S. Salihagic, D. Salnikov, A. Salt, J. Ferrando, B.M.S. Salvatore, D. Salvatore, F. Salvucci, A. Salzburger, A. Sampsonidis, D. Samset, B.H. Sandaker, H. Sander, H.G. Sanders, M.P. Sandhoff, M. Sandhu, P. Sandstroem, R. Sandvoss, S. Sankey, D.P.C. Sanny, B. Sansoni, A. Rios, C.S. Santoni, C. Santonico, R. Saraiva, J.G. Sarangi, T. Sarkisyan-Grinbaum, E. Sarri, F. Sasaki, O. Sasao, N. Satsounkevitch, I. Sauvage, G. Savard, P. Savine, A.Y. Savinov, V. Sawyer, L. Saxon, D.H. Says, L.P. Sbarra, C. Sbrizzi, A. Scannicchio, D.A. Schaarschmidt, J. Schacht, P. Schäfer, U. Schaetzel, S. Schaffer, A.C. Schaile, D. Schamberger, R.D. Schamov, A.G. Scharf, V. Schegelsky, V.A. Scheirich, D. Schernau, M. Scherzer, M.I. Schiavi, C. Schieck, J. Schioppa, M. Schlenker, S. Schmidt, E. Schmieden, K. Schmitt, C. Schmitz, M. Schönig, A. Schott, M. Schouten, D. Schovancova, J. Schram, M. Schreiner, A. Schroeder, C. Schroer, N. Schroers, M. Schultes, J. Schultz-Coulon, H.-C. Schumacher, J.W. Schumacher, M. Schumm, B.A. Schune, P. Schwanenberger, C. Schwartzman, A. Schwemling, P. Schwienhorst, R. Schwierz, R. Schwindling, J. Scott, W.G. Searcy, J. Sedykh, E. Segura, E. Seidel, S.C. Seiden, A. Seifert, F. Seixas, J.M. Sekhniaidze, G. Seliverstov, D.M. Sellden, B. Semprini-Cesari, N. Serfon, C. Serin, L. Seuster, R. Severini, H. Sevior, M.E. Sfyrla, A. Shabalina, E. Shamim, M. Shan, L.Y. Shank, J.T. Shao, Q.T. Shapiro, M. Shatalov, P.B. Shaw, K. Sherman, D. Sherwood, P. Shibata, A. Shimojima, M. Shin, T. Shmeleva, A. Shochet, M.J. Shupe, M.A. Sicho, P. Sidoti, A. Siegert, F. Siegrist, J. Sijacki, D. Silbert, O. Silva, J. Silver, Y. Silverstein, D. Silverstein, S.B. Simak, V. Simic, L. Simion, S. Simmons, B. Simonyan, M. Sinervo, P. Sinev, N.B. Sipica, V. Siragusa, G. Sisakyan, A.N. Sivoklokov, S.Y. Sjoelin, J. Sjursen, T.B. Skovpen, K. Skubic, P. Slater, M. Slavicek, T. Sliwa, K. Sloper, J. Smakhtin, V. Smirnov, S.Y. Smirnov, Y. Smirnova, L.N. Smirnova, O. Smith, B.C. Smith, D. Smith, K.M. Smizanska, M. Smolek, K. Snesarev, A.A. Snow, S.W. Snow, J. Snuverink, J. Snyder, S. Soares, M. Sobie, R. Sodomka, J. Soffer, A. Solans, C.A. Solar, M. Solc, J. Camillocci, E.S. Solodkov, A.A. Solovyanov, O.V. Sondericker, J. Sopko, V. Sopko, B. Sosebee, M. Soukharev, A. Spagnolo, S. Spanò, F. Spighi, R. Spigo, G. Spila, F. Spiwoks, R. Spousta, M. Spreitzer, T. Spurlock, B. Denis, R.D.S. Stahl, T. Stahlman, J. Stamen, R. Stancu, S.N. Stanecka, E. Stanek, R.W. Stanescu, C. Stapnes, S. Starchenko, E.A. Stark, J. Staroba, P. Starovoitov, P. Stastny, J. Stavina, P. Steele, G. Steinbach, P. Steinberg, P. Stekl, I. Stelzer, B. Stelzer, H.J. Stelzer-Chilton, O. Stenzel, H. Stevenson, K. Stewart, G.A. Stockton, M.C. Stoerig, K. Stoicea, G. Stonjek, S. Strachota, P. Stradling, A.R. Straessner, A. Strandberg, J. Strandberg, S. Strandlie, A. Strauss, M. Strizenec, P. Ströhmer, R. Strom, D.M. Stroynowski, R. Strube, J. Stugu, B. Sturm, P. Soh, D.A. Su, D. Sugaya, Y. Sugimoto, T. Suhr, C. Suk, M. Sulin, V.V. Sultansoy, S. Sumida, T. Sun, X.H. Sundermann, J.E. Suruliz, K. Sushkov, S. Susinno, G. Sutton, M.R. Suzuki, T. Suzuki, Y. Sykora, I. Sykora, T. Szymocha, T. Sánchez, J. Ta, D. Tackmann, K. Taffard, A. Tafirout, R. Taga, A. Takahashi, Y. Takai, H. Takashima, R. Takeda, H. Takeshita, T. Talby, M. Talyshev, A. Tamsett, M.C. Tanaka, J. Tanaka, R. Tanaka, S. Tanaka, S. Tapprogge, S. Tardif, D. Tarem, S. Tarrade, F. Tartarelli, G.F. Tas, P. Tasevsky, M. Tassi, E. Tatarkhanov, M. Taylor, C. Taylor, F.E. Taylor, G.N. Taylor, R.P. Taylor, W. Teixeira-Dias, P. Kate, H.T. Teng, P.K. Tennenbaum-Katan, Y.D. Terada, S. Terashi, K. Terron, J. Terwort, M. Testa, M. Teuscher, R.J. Therhaag, J. Thioye, M. Thoma, S. Thomas, J.P. Thompson, E.N. Thompson, P.D. Thompson, P.D. Thompson, R.J. Thompson, A.S. Thomson, E. Thun, R.P. Tic, T. Tikhomirov, V.O. Tikhonov, Y.A. Tipton, P. Aires Viegas, F.J.T. Tisserant, S. Toczek, B. Todorov, T. Todorova-Nova, S. Toggerson, B. Tojo, J. Tokár, S. Tokushuku, K. Tollefson, K. Tomasek, L. Tomasek, M. Tomoto, M. Tompkins, L. Toms, K. Tonoyan, A. Topfel, C. Topilin, N.D. Torchiani, I. Torrence, E. Pastor, E.T. Toth, J. Touchard, F. Tovey, D.R. Trefzger, T. Tremblet, L. Tricoli, A. Trigger, I.M. Trincaz-Duvoid, S. Trinh, T.N. Tripiana, M.F. Triplett, N. Trischuk, W. Trivedi, A. Trocmé, B. Troncon, C. Trzupek, A. Tsarouchas, C. Tseng, J.C.-L. Tsiakiris, M. Tsiareshka, P.V. Tsionou, D. Tsipolitis, G. Tsiskaridze, V. Tskhadadze, E.G. Tsukerman, I.I. Tsulaia, V. Tsung, J.-W. Tsuno, S. Tsybychev, D. Tuggle, J.M. Turecek, D. Cakir, I.T. Turlay, E. Tuts, P.M. Twomey, M.S. Tylmad, M. Tyndel, M. Uchida, K. Ueda, I. Ueno, R. Ugland, M. Uhlenbrock, M. Uhrmacher, M. Ukegawa, F. Unal, G. Undrus, A. Unel, G. Unno, Y. Urbaniec, D. Urkovsky, E. Urquijo, P. Urrejola, P. Usai, G. Uslenghi, M. Vacavant, L. Vacek, V. Vachon, B. Vahsen, S. Valente, P. Valentinetti, S. Valkar, S. Gallego, E.V. Vallecorsa, S. Ferrer, J.A.V. van Berg, R. van der Graaf, H. van der Kraaij, E. van der Poel, E. van der Ster, D. van Eldik, N. van Gemmeren, P. van Kesteren, Z. van Vulpen, I. Vandelli, W. Vaniachine, A. Vankov, P. Vannucci, F. Vari, R. Varnes, E.W. Varouchas, D. Vartapetian, A. Varvell, K.E. Vasilyeva, L. Vassilakopoulos, V.I. Vazeille, F. Vellidis, C. Veloso, F. Veneziano, S. Ventura, A. Ventura, D. Venturi, M. Venturi, N. Vercesi, V. Verducci, M. Verkerke, W. Vermeulen, J.C. Vetterli, M.C. Vichou, I. Vickey, T. Viehhauser, G.H.A. Villa, M. Villani, E.G. Perez, M.V. Vilucchi, E. Vincter, M.G. Vinek, E. Vinogradov, V.B. Viret, S. Virzi, J. Vitale, A. Vitells, O. Vivarelli, I. Vaque, F.V. Vlachos, S. Vlasak, M. Vlasov, N. Vogel, A. Vokac, P. Volpi, M. von der Schmitt, H. von Loeben, J. von Radziewski, H. von Toerne, E. Vorobel, V. Vorwerk, V. Vos, M. Voss, R. Voss, T.T. Vossebeld, J.H. Vranjes, N. Milosavljevic, M.V. Vrba, V. Vreeswijk, M. Anh, T.V. Vudragovic, D. Vuillermet, R. Vukotic, I. Wagner, P. Walbersloh, J. Walder, J. Walker, R. Walkowiak, W. Wall, R. Wang, C. Wang, H. Wang, J. Wang, S.M. Warburton, A. Ward, C.P. Warsinsky, M. Wastie, R. Watkins, P.M. Watson, A.T. Watson, M.F. Watts, G. Watts, S. Waugh, A.T. Waugh, B.M. Weber, M.D. Weber, M. Weber, M.S. Weber, P. Weidberg, A.R. Weingarten, J. Weiser, C. Wellenstein, H. Wells, P.S. Wenaus, T. Wendler, S. Wengler, T. Wenig, S. Wermes, N. Werner, M. Werner, P. Werth, M. Werthenbach, U. Wessels, M. Whalen, K. White, A. White, M.J. White, S. Whitehead, S.R. Whiteson, D. Whittington, D. Wicek, F. Wicke, D. Wickens, F.J. Wiedenmann, W. Wielers, M. Wienemann, P. Wiglesworth, C. Wiik, L.A.M. Wildauer, A. Wildt, M.A. Wilkens, H.G. Williams, E. Williams, H.H. Willocq, S. Wilson, J.A. Wilson, M.G. Wilson, A. Wingerter-Seez, I. Winklmeier, F. Wittgen, M. Wolter, M.W. Wolters, H. Wosiek, B.K. Wotschack, J. Woudstra, M.J. Wraight, K. Wright, C. Wright, D. Wrona, B. Wu, S.L. Wu, X. Wulf, E. Wynne, B.M. Xaplanteris, L. Xella, S. Xie, S. Xu, D. Xu, N. Yamada, M. Yamamoto, A. Yamamoto, K. Yamamoto, S. Yamamura, T. Yamaoka, J. Yamazaki, T. Yamazaki, Y. Yan, Z. Yang, H. Yang, U.K. Yang, Z. Yao, W.-M. Yao, Y. Yasu, Y. Ye, J. Ye, S. Yilmaz, M. Yoosoofmiya, R. Yorita, K. Yoshida, R. Young, C. Youssef, S.P. Yu, D. Yu, J. Yuan, L. Yurkewicz, A. Zaidan, R. Zaitsev, A.M. Zajacova, Z. Zambrano, V. Zanello, L. Zaytsev, A. Zeitnitz, C. Zeller, M. Zemla, A. Zendler, C. Zenin, O. Zenis, T. Zenonos, Z. Zenz, S. Zerwas, D. della Porta, G.Z. Zhan, Z. Zhang, H. Zhang, J. Zhang, Q. Zhang, X. Zhao, L. Zhao, T. Zhao, Z. Zhemchugov, A. Zhong, J. Zhou, B. Zhou, N. Zhou, Y. Zhu, C.G. Zhu, H. Zhu, Y. Zhuang, X. Zhuravlov, V. Zimmermann, R. Zimmermann, S. Zimmermann, S. Ziolkowski, M. Živković, L. Zobernig, G. Zoccoli, A. zur Nedden, M. Zutshi, V.

Subjects
Physics::Instrumentation and Detectors
Abstract

The ATLAS Inner Detector is a composite tracking system consisting of silicon pixels, silicon strips and straw tubes in a 2 T magnetic field. Its installation was completed in August 2008 and the detector took part in data-taking with single LHC beams and cosmic rays. The initial detector operation, hardware commissioning and in-situ calibrations are described. Tracking performance has been measured with 7. 6 million cosmic-ray events, collected using a tracking trigger and reconstructed with modular pattern-recognition and fitting software. The intrinsic hit efficiency and tracking trigger efficiencies are close to 100%. Lorentz angle measurements for both electrons and holes, specific energy-loss calibration and transition radiation turn-on measurements have been performed. Different alignment techniques have been used to reconstruct the detector geometry. After the initial alignment, a transverse impact parameter resolution of 22. 1±0. 9 μm and a relative momentum resolution σp/p=(4. 83±0. 16)×10-4 GeV-1×pT have been measured for high momentum tracks. © 2010 CERN for the benefit of the ATLAS collaboration.

Published
2010

8. MUSCULOSKELETAL DISORDERS AMONG MUNICIPAL SOLID WASTE WORKERS

Author

R. Mehrdad, M. Majlessi-Nasr, O. Aminian, and S. A. Sharifian F. Malekahmadi

Subjects
Solid waste workers, Medicine (General), R5-920
Abstract

Waste collection is a necessary activity all around the world and the removal of municipal solid waste is a job associated with a variety of biological, chemical, mechanical, physical, and psychosocial hazards. In our country, like many developing countries, municipal solid waste is collected manually and collection of household waste is also a job which requires repeated heavy physical activity such as lifting, carrying, pulling, and pushing. We performed this study to evaluate musculoskeletal disorders among municipal solid waste workers. We designed a cross sectional study. Our survey instrument for measurement of musculoskeletal symptoms was adapted from the Standardized Nordic Questionnaire that translated into Farsi language. A total of 65% (n=142) of participants reported that they had been troubled with musculoskeletal symptoms in one or more of the 9 defined body regions during the last 12 months. Prevalence of symptoms in low back, knees, shoulders, upper back and neck were 45, 29, 24, 23 and 22% respectively. Foreign workers reported more musculoskeletal symptoms in all body parts than Iranian workers. The differences between prevalence of symptoms between two groups were significant in all parts of body except knees. The study found that solid waste workers have more musculoskeletal disorders than general population. Meanwhile these symptoms were more common among foreign workers. The risk of disease was increased with the increasing years of working as solid waste worker and smoking. We didn't find relationship between musculoskeletal disorders and education or marriage status of workers.

Published
2008

9. Covariant second variation for first order Lagrangians on fibered manifolds II: generalized curvature and Bianchi identities

Author

O. AMICI, B. CASCIARO, and M. FRANCAVIGLIA

Subjects
second variation, generalized curvature tensorfields, bianchi identities, Mathematics, QA1-939
Abstract

The notion of generalized curvature structures ensuing from the second variation of a (first–order) Lagrangian is extensively discussed. It is shown that generalized curvature structures satisfy appropriate (generalized) Bianchi identities. Formulae applicable to curvature Lagrangians are developed in great detail. Examples are taken from the theory of generalized harmonic Lagrangians.

Published
1996

10. Childbirth simulation to assess cephalopelvic disproportion and chances for failed labor in a French population.

Author

Ami O, Maran JC, Cohen A, Hendler I, Zabukovek E, and Boyer L

Subjects
Pregnancy, Humans, Female, Retrospective Studies, Delivery, Obstetric methods, Parturition, Cesarean Section, Cephalopelvic Disproportion epidemiology
Abstract

Reducing failed labor and emergency cesarean section (CS) rates is an important goal. A childbirth simulation tool (PREDIBIRTH software and SIM37 platform) that evaluates a 5-min magnetic resonance imaging (MRI) assessment performed at 37 weeks of gestation was developed to enhance the consulting obstetrician's ability to predict the optimal delivery mode. We aimed to determine the potential value of this childbirth simulation tool in facilitating the selection of an optimal delivery mode for both mother and infant. A retrospective cohort study was performed on all patients referred by their obstetricians to our level 2 maternity radiology department between December 15, 2015 and November 15, 2016, to undergo MRI pelvimetry at approximately 37 weeks of gestation. The childbirth simulation software was employed to predict the optimal delivery mode based on the assessment of cephalopelvic disproportion. The prediction was compared with the actual outcome for each case. Including childbirth simulations in the decision-making process had the potential to reduce emergency CSs, inappropriately scheduled CSs, and instrumental vaginal deliveries by up to 30.1%, 20.7%, and 20.0%, respectively. Although the use of the simulation tool might not have affected the overall CS rate, consideration of predicted birthing outcomes has the potential to improve the allocation between scheduled CS and trial of labor. The routine use of childbirth simulation software as a clinical support tool when choosing the optimal delivery mode for singleton pregnancies with a cephalic presentation could reduce the number of emergency CSs, insufficiently justified CSs, and instrumental deliveries., (© 2023. The Author(s).)

Published
2023
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11. Using Magnetic Resonance Imaging During Childbirth to Demonstrate Fetal Head Moldability and Brain Compression: Prospective Cohort Study.

Author

Ami O, Maran JC, Musset D, Dubray C, Mage G, and Boyer L

Abstract

Background: Childbirth is a physiological process with significant medical risk, given that neurological impairment due to the birthing process can occur at any time. Improvements in risk assessment and anticipatory interventions are constantly needed; however, the birthing process is difficult to assess using simple imaging technology because the maternal bony pelvis and fetal skeleton interfere with visualizing the soft tissues. Magnetic resonance imaging (MRI) is a noninvasive technique with no ionizing radiation that can monitor the biomechanics of the birthing process. However, the effective use of this modality requires teamwork and the implementation of the appropriate safeguards to achieve appropriate safety levels., Objective: This study describes a clinically effective and safe method to perform real-time MRI during the birthing process. We reported the experience of our team as part of the IMAGINAITRE study protocol (France), which aimed to better understand the biomechanics of childbirth., Methods: A total of 27 pregnant women were examined with 3D MRI sequences before going into labor using a 1-Tesla open-field MRI. Of these 27 patients, 7 (26%) subsequently had another set of 3D MRI sequences during the second stage of labor. Volumes of 2D images were transformed into finite element 3D reconstructions. Polygonal meshes for each part of the fetal body were used to study fetal head moldability and brain compression., Results: All 7 observed babies showed a sugarloaf skull deformity and brain compression at the middle strait. The fetus showing the greatest degree of molding and brain shape deformation weighed 4525 g and was born spontaneously but also presented with a low Apgar score. In this case, observable brain shape deformation demonstrated that brain compression had occurred, and it was not necessarily well tolerated by the fetus. Depending on fetal head moldability, these observations suggest that cephalopelvic disproportion can result in either obstructed labor or major fetal head molding with brain compression., Conclusions: This study suggests the presence of skull moldability as a confounding factor explaining why MRI, even with the best precision to measure radiological landmarks, fails to accurately predict the modality of childbirth. This introduces the fetal head compliance criterion as a way to better understand cephalopelvic disproportion mechanisms in obstetrics. MRI might be the best imaging technology by which to explore all combined aspects of cephalopelvic disproportion and achieve a better understanding of the underlying mechanisms of fetal head molding and moldability., (©Olivier Ami, Jean-Christophe Maran, Dominique Musset, Claude Dubray, Gérard Mage, Louis Boyer. Originally published in JMIR Formative Research (https://formative.jmir.org), 30.11.2022.)

Published
2022
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12. Double-layered purse string uterine suture compared with single-layer continuous uterine suture: A randomized Controlled trial.

Author

Dimassi K, Ami O, Merai R, Velemir L, Simon B, Fauck D, and Triki A

Subjects
Adult, Female, Humans, Operative Time, Pregnancy, Prospective Studies, Cesarean Section methods, Cicatrix prevention & control, Suture Techniques instrumentation, Uterus surgery
Abstract

Background: With the aim of preventing cesarean scar defects, we introduced a new technique involving a purse string uterine suture. To date, this uterine suture technique has not been formally evaluated. The objective of the study was to test the hypothesis that compared to single layer continuous uterine suture (SLCUS), a double layered purse string uterine suture (PSUS) significantly reduces cesarean scar defect (CSD) rates, without increasing the perioperative maternal morbidity., Methods: A prospective randomized study. Primary outcome was the rate of CSD. 100 patients were enrolled in 2 groups according to the uterine suture technique. A hysterosonography was performed by the same senior obstetrician blinded to the uterine suture technique 6 months after surgery .Operative time and calculated blood loss (CBL) were used for the short time analysis. Uterine and CSD measurements were used for the mid time analysis., Results: Despite a longer operative time with PSUS (7.17 ± 2.31 min Vs. 6.31 ± 3.04 min, p = 0.028; p <10‾³); there was no significant difference in terms of CBL (520 ± 58 with PSUS vs. 536 ± 50 ml, p = 0.724). There was a significant decrease in the rate of CSD with PSUS: 6.66% Vs.40% with SLUCS; p<0.001. Moreover, SLUCS was the leading risk factor for CSD: adjusted OR=6; 95% CI [0-1], p<10‾³)., Conclusion: Compared to single layer continuous suture, double layered purse stringuterine suture significantly reduces cesarean scar defect rates, without increasing the perioperative maternal morbidity., Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests, (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)

Published
2022
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13. The extraperitoneal French AmbUlatory cesarean section technique leads to improved pain scores and a faster maternal autonomy compared with the intraperitoneal Misgav Ladach technique: A prospective randomized controlled trial.

Author

Dimassi K, Halouani A, Kammoun A, Ami O, Simon B, Velemir L, Fauck D, and Triki A

Subjects
Adult, Female, Humans, Pregnancy, Prospective Studies, Cesarean Section, Pain, Postoperative prevention & control, Postoperative Period
Abstract

Objective: To determine whether the French AmbUlatory Cesarean Section (FAUCS) technique reduces postoperative pain and promotes maternal autonomy compared with the Misgav Ladach cesarean section (MLCS) technique in elective conditions., Study Design: One hundred pregnant women were randomly, but in a non-blinded manner, assigned to undergo FAUCS or MLCS. The primary outcome was a postoperative mean pain score (PMPS), and secondary outcomes were a combined pain/medication score, time to regain autonomy, surgical duration, calculated blood loss, surgical complications, and neonatal outcome., Results: Women in the FAUCS group experienced less pain than those in the MLCS group (PMPS = 1.87 [1.04-2.41] vs. 2.93 [2.46-3.75], respectively; p < 0.001). Six hours after surgery, the combined pain/medication score for FAUCS patients was 33% lower than that for MLCS patients (p < 0.001). FAUCS patients more rapidly regained autonomy, with 94% reaching autonomy within 12 h vs. 4% of MLCS patients (p < 0.001). There were no differences in maternal surgical or neonatal complications between groups., Conclusions: Our results indicate that FAUCS can reduce postoperative pain and accelerate recovery, suggesting that this technique might be superior to MLCS and should be more widely used. One potentially key difference between FAUCS and MLCS is that MLCS includes 100 mcg spinal morphine anesthesia in addition to the same anesthesia used by FAUCS. Any interpretation of apparent differences must take the presence/absence of morphine into account., Competing Interests: The authors have read the journal's policy, and the authors of this study have the following competing interests to share: OA, BS, and DF work for Ramsay Health Care. However, none of the authors receive a salary for their work, nor did they receive any funding for this research. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.

Published
2021
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14. French ambulatory cesarean: Mother and newborn safety.

Author

Dimassi K, Ami O, Fauck D, Simon B, Velemir L, and Triki A

Subjects
Adult, Blood Loss, Surgical statistics & numerical data, Cesarean Section statistics & numerical data, Female, Humans, Infant, Newborn, Operative Time, Pain, Postoperative etiology, Pregnancy, Prospective Studies, Tunisia, Cesarean Section methods
Abstract

Objective: To evaluate mother and newborn child safety after French ambulatory cesarean (FAUCS)., Methods: Prospective comparative cohort study in Tunisia (January-June 2018). Pregnant women indicated for primary or repeat cesarean at term underwent FAUCS or Misgav Ladach cesarean (MLC). Surgical outcomes, overall morbidity, and maternal autonomy during recovery were compared., Results: Among 112 deliveries, 60 were performed by FAUCS and 52 by MLC. FAUCS was feasible in all cases; surgeons achieved a completely extraperitoneal approach in 39 (65.0%) cases. The main difficulty experienced was fetal extraction. Longer operative procedures were recorded in the FAUCS group; however, women in the FAUCS group reported lower pain scores (3 [2-5] vs 4 [3.7-5], P<0.001) and were more likely to decline analgesics (10 [17.0%] vs 0 [0%], P<0.001). They experienced greater autonomy during recovery (median [interquartile range] time to standing, 2 [1.0-2.5] vs 12.8 [8.9-17.9] hours, P<0.001; time to full meal, 4 [3-6[ vs 26.5 [21-31] hours, P<0.001; effective time to hospital discharge, 1 [1, 2] vs 2 [2, 3] days; P<0.001)., Conclusion: Implementation of the FAUCS technique was safe and successful, and improved maternal condition after cesarean. These short-term results need long-term validation by randomized trials., (© 2019 International Federation of Gynecology and Obstetrics.)

Published
2020
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15. Three-dimensional magnetic resonance imaging of fetal head molding and brain shape changes during the second stage of labor.

Author

Ami O, Maran JC, Gabor P, Whitacre EB, Musset D, Dubray C, Mage G, and Boyer L

Subjects
Adult, Brain anatomy & histology, Brain diagnostic imaging, Female, Humans, Organ Size, Pregnancy, Young Adult, Fetus anatomy & histology, Fetus diagnostic imaging, Head anatomy & histology, Head diagnostic imaging, Imaging, Three-Dimensional, Labor Stage, Second, Magnetic Resonance Imaging
Abstract

To demonstrate and describe fetal head molding and brain shape changes during delivery, we used three-dimensional (3D) magnetic resonance imaging (MRI) and 3D finite element mesh reconstructions to compare the fetal head between prelabor and the second stage of labor. A total of 27 pregnant women were examined with 3D MRI sequences before going into labor using a 1 Tesla open field MRI. Seven of these patients subsequently had another set of 3D MRI sequences during the second stage of labor. Volumes of 2D images were transformed into finite element 3D reconstructions. Polygonal meshes for each part of the fetal body were used to study fetal head molding and brain shape changes. Varying degrees of fetal head molding were present in the infants of all seven patients studied during the second phase of labor compared with the images acquired before birth. The cranial deformation, however, was no longer observed after birth in five out of the seven newborns, whose post-natal cranial parameters were identical to those measured before delivery. The changing shape of the fetal brain following the molding process and constraints on the brain tissue were observed in all the fetuses. Of the three fetuses presenting the greatest molding of the skull bones and brain shape deformation, two were delivered by cesarean-section (one after a forceps failure and one for engagement default), while the fetus presenting with the greatest skull molding and brain shape deformation was born physiologically. This study demonstrates the value of 3D MRI study with 3D finite element mesh reconstruction during the second stage of labor to reveal how the fetal brain is impacted by the molding of the cranial bones. Fetal head molding was systematically observed when the fetal head was engaged between the superior pelvic strait and the middle brim., Competing Interests: The authors have declared that no competing interests exist.

Published
2019
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17. Comparative anatomy on 3-D MRI of the urogenital sinus and the periurethral area before and during the second stage of labor during childbirth.

Author

Maran JC, Cassagnes L, Delmas V, Musset D, Frydman R, Mage G, Canis M, Boyer L, and Ami O

Subjects
Adult, Anatomy, Comparative, Female, Humans, Muscle, Skeletal diagnostic imaging, Pelvic Floor diagnostic imaging, Perineum diagnostic imaging, Pregnancy, Sacrococcygeal Region diagnostic imaging, Urogenital System diagnostic imaging, Imaging, Three-Dimensional methods, Labor Stage, Second, Magnetic Resonance Imaging methods, Muscle, Skeletal anatomy & histology, Pelvic Floor anatomy & histology, Perineum anatomy & histology, Sacrococcygeal Region anatomy & histology, Urogenital System anatomy & histology
Abstract

Purpose of the Study: To describe the observable MRI changes in the urogenital sinus during the second stage of labor and delivery by comparing the changes in the positions of the anatomical structures of the maternal perineum using MRI-based vector 3-D models., Materials and Methods: Seven pregnant women underwent 3-D MRI sequences using a Philips 1 T Panorama open MRI during the pre-labor period and during the second stage of labor. A 3-D vector reconstruction platform (BABYPROGRESS, France) enabled the transformation of volumes of 2-D images into finite element meshes. The polygonal meshes labeled with the principal components of the urogenital sinus were used as part of a biomechanical study of the pressure exerted on the perineum during fetal descent., Results: The expansion of the urogenital sinus was observed in all patients. Qualitative stretching was observed toward the rear and bottom of the iliococcygeus, pubococcygeus, puborectalis and obturator internus muscles. Significant length differences were measured along the iliococcygeus and pubococcygeus muscles but not along the tendinous arch of the levator ani or the puborectalis muscle. The inversion of the levator ani muscle curvature was accompanied by the transmission of pressure generated during fetal descent to the pubic muscle insertions and the descent of the tendinous arch of the levator ani., Conclusion: Mechanical pressures responsible for the tensioning of the constituent muscles of the urogenital sinus were qualitatively identified during the second stage of labor. MRI-based vector 3-D models allow the quantitative assessment of levator ani muscle stretching during labor, but 2-D MRI is not sufficient for describing perineal expansion. Vector 3-D models from larger scale studies have the potential to aid in the calibration of a realistic simulation based on the consideration of the reaction of each muscular element. These models offer perspectives to enhance our knowledge regarding perineal expansion during childbirth as a risk factor for postpartum perineal defects.

Published
2018
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18. Quantification of elasticity changes in the myometrium during labor using Supersonic Shear Imaging: a feasibility study.

Author

Gennisson JL, Muller M, Gabor P, Frydman R, Musset D, Tanter M, and Ami O

Subjects
Feasibility Studies, Female, Humans, Pregnancy, Elasticity Imaging Techniques methods, Labor, Obstetric physiology, Myometrium physiology, Uterine Contraction physiology
Abstract

Very little is known about the myometrium's physiology in terms of its elasticity but shear wave elastography could be an efficient tool to better understand it. This could considerably help the prevention of difficult births, the consequences of which are tremendous for neonate morbidity and pathologies. The purpose of this paper is to show the feasibility of the in vivo monitoring of myometrial stiffness changes in contraction and relaxation during pregnancy. In this study, Supersonic Shear Wave Imaging, a real-time and quantitative imaging technique that has been proven efficient for the investigation of tissue elasticity, was used to quantify the uterus shear-wave speed and stiffness in 6 patients, through the abdomen, using an 8-MHz linear ultrasound probe. Changes in shear wave speed were tracked in real time during the uterine contraction and were well correlated with the uterine pressure, which is currently considered to be a gold standard. These results open a new way to better understand the myometrium contraction during labour., (Copyright © 2014 Elsevier B.V. All rights reserved.)

Published
2015
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19. First-trimester nuchal abnormalities secondary to dehydrated hereditary stomatocytosis.

Author

Ami O, Picone O, Garçon L, Castel C, Guitton C, Delaunay J, Frydman R, and Senat MV

Subjects
Adult, Diagnosis, Differential, Female, Humans, Infant, Infant, Newborn, Male, Pregnancy, Anemia, Hemolytic, Congenital diagnostic imaging, Diagnostic Errors, Nuchal Translucency Measurement, Pregnancy Complications diagnostic imaging, Pregnancy Trimester, First physiology
Published
2009
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21. Beckwith-Wiedemann syndrome in association with posterior hypoplasia of the cerebellar vermis.

Author

Bui C, Picone O, Mas AE, Levaillant JM, Ami O, Netchine I, Frydman R, and Senat MV

Subjects
Abnormalities, Multiple pathology, Adult, Autopsy, Beckwith-Wiedemann Syndrome diagnosis, Beckwith-Wiedemann Syndrome pathology, Cerebellum pathology, Female, Humans, Pregnancy, Prenatal Diagnosis, Abnormalities, Multiple diagnosis, Beckwith-Wiedemann Syndrome complications, Cerebellum abnormalities
Published
2009
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