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283 results on '"Noma, Kazuhiro"'

2. Comparison of proton-based definitive chemoradiotherapy and surgery-based therapy for esophageal squamous cell carcinoma: a multi-center retrospective Japanese cohort study

Author

Ogawa, Koichi, Ishikawa, Hitoshi, Toyozumi, Takeshi, Noma, Kazuhiro, Kono, Koji, Hojo, Hidehiro, Tamamura, Hiroyasu, Azami, Yusuke, Ishida, Toshiki, Nabeya, Yoshihiro, Iwata, Hiromitsu, Araya, Masayuki, Tokumaru, Sunao, Maruo, Kazushi, Oda, Tatsuya, and Matsubara, Hisahiro

Published
2024
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3. Fibroblast activation protein-targeted near-infrared photoimmunotherapy depletes immunosuppressive cancer-associated fibroblasts and remodels local tumor immunity

Author

Akai, Masaaki, Noma, Kazuhiro, Kato, Takuya, Nishimura, Seitaro, Matsumoto, Hijiri, Kawasaki, Kento, Kunitomo, Tomoyoshi, Kobayashi, Teruki, Nishiwaki, Noriyuki, Kashima, Hajime, Kikuchi, Satoru, Ohara, Toshiaki, Tazawa, Hiroshi, Choyke, Peter L., Kobayashi, Hisataka, and Fujiwara, Toshiyoshi

Published
2024
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5. Correction: Comparison of proton-based Definitive chemoradiotherapy and surgery-based therapy for esophageal squamous cell carcinoma: a multi-center retrospective Japanese cohort study

Author

Ogawa, Koichi, Ishikawa, Hitoshi, Toyozumi, Takeshi, Noma, Kazuhiro, Kono, Koji, Hojo, Hidehiro, Tamamura, Hiroyasu, Azami, Yusuke, Ishida, Toshiki, Nabeya, Yoshihiro, Iwata, Hiromitsu, Araya, Masayuki, Tokumaru, Sunao, Maruo, Kazushi, Oda, Tatsuya, and Matsubara, Hisahiro

Published
2024
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7. PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer

Author

Kawasaki, Kento, Noma, Kazuhiro, Kato, Takuya, Ohara, Toshiaki, Tanabe, Shunsuke, Takeda, Yasushige, Matsumoto, Hijiri, Nishimura, Seitaro, Kunitomo, Tomoyoshi, Akai, Masaaki, Kobayashi, Teruki, Nishiwaki, Noriyuki, Kashima, Hajime, Maeda, Naoaki, Kikuchi, Satoru, Tazawa, Hiroshi, Shirakawa, Yasuhiro, and Fujiwara, Toshiyoshi

Published
2023
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23. Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment

Author

Sato, Hiroaki, Noma, Kazuhiro, Ohara, Toshiaki, Kawasaki, Kento, Akai, Masaaki, Kobayashi, Teruki, Nishiwaki, Noriyuki, Narusaka, Toru, Komoto, Satoshi, Kashima, Hajime, Katsura, Yuki, Kato, Takuya, Kikuchi, Satoru, Tazawa, Hiroshi, Kagawa, Shunsuke, Shirakawa, Yasuhiro, Kobayashi, Hisataka, and Fujiwara, Toshiyoshi

Published
2022
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24. Perioperative and Postoperative Continuous Nutritional Counseling Improves Quality of Life of Gastric Cancer Patient Undergoing Gastrectomy.

Author

Hanzawa, Shunya, Kikuchi, Satoru, Kuroda, Shinji, Shoji, Ryohei, Kashima, Hajime, Matsumi, Yuki, Takahashi, Ayako, Kakiuchi, Yoshihiko, Takagi, Kosei, Tanabe, Shunsuke, Noma, Kazuhiro, Kagawa, Shunsuke, Shikata, Kenichi, and Fujiwara, Toshiyoshi

Subjects
POSTOPERATIVE care, GASTRECTOMY, DIARRHEA, STOMACH tumors, FOOD consumption, NUTRITION counseling, BODY weight, MULTIPLE regression analysis, ABDOMINAL pain, QUESTIONNAIRES, EVALUATION of medical care, RETROSPECTIVE studies, FUNCTIONAL status, QUALITY of life, MEDICAL records, ACQUISITION of data, POSTOPERATIVE period, CANCER patient psychology, COMPARATIVE studies, PATIENT satisfaction, PERIOPERATIVE care, PATIENTS' attitudes
Abstract

Post-gastrectomy syndrome (PGS) and body weight loss (BWL) decrease quality of life (QOL) and survival of the patient undergoing gastrectomy. We have introduced perioperative and post-discharge continuous nutritional counseling (CNC) to prevent BWL and improve QOL after gastrectomy. In the present study, we evaluated the effect of CNC on QOL using the Post-gastrectomy Syndrome Assessment Scale-45 (PGSAS-45). Eighty-three patients with gastric cancer (GC) who underwent curative gastrectomy between March 2018 and July 2019 were retrospectively analyzed. Patients received either pre-discharge nutritional counseling alone (control group, n = 45) or CNC (CNC group, n = 38) after gastrectomy. QOL at 12 months after gastrectomy was compared between the two groups. In QOL assessment, change in body weight (−7.98% vs. −12.77%, p = 0.0057), ingested amount of food per meal (7.00 vs. 6.07, p = 0.042) and ability for working (1.89 vs. 2.36, p = 0.049) were significantly better in CNC group than control group. Multiple regression analysis showed that CNC was a significantly beneficial factor for abdominal pain subscale (p = 0.028), diarrhea subscale (p = 0.047), ingested amount of food per meal (p = 0.012), Ability for working (p = 0.031) and dissatisfaction at the meal (p = 0.047). Perioperative and postoperative CNC could improve QOL in the patient undergoing gastrectomy in addition to preventing postoperative BWL. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Validity of the 30-Second Chair-Stand Test to Assess Exercise Tolerance and Clinical Outcomes in Patients with Esophageal Cancer: A Retrospective Study with Reference to 6-Minute Walk Test Results

Author

Ikeda, Tomohiro, Noma, Kazuhiro, Okura, Kazuki, Katayama, Sho, Takahashi, Yusuke, Maeda, Naoaki, Tanabe, Shunsuke, Wakita, Akiyuki, Hamada, Masanori, Fujiwara, Toshiyoshi, and Senda, Masuo

Subjects
exercise tolerance, esophageal cancer, rehabilitation
Abstract

This retrospective study aimed to investigate the validity of a 30-sec chair stand test (CS-30) as a simple test to assess exercise tolerance and clinical outcomes in 53 Japanese patients with esophageal cancer. There was a strong correlation between the results of CS-30 and the 6-min walk test (6MWT), the gold standard for assessing exercise tolerance (r=0.759). Furthermore, fewer patients whose CS-30 score was greater than 16 (the cutoff value defined based on 6MWT) experienced pneumonia in their postoperative course. These results suggest that exercise tolerance could be assessed using CS-30, and its cutoff value may be useful in predicting postoperative pneumonia risk.

Published
2023

37. Recurrence-free survival as a surrogate endpoint for overall survival after neoadjuvant chemotherapy and surgery for oesophageal squamous cell carcinoma.

Author

Okui, Jun, Nagashima, Kengo, Matsuda, Satoru, Sato, Yasunori, Okamura, Akihiko, Kawakubo, Hirofumi, Muto, Manabu, Kakeji, Yoshihiro, Kono, Koji, Takeuchi, Hiroya, Watanabe, Masayuki, Doki, Yuichiro, Bamba, Takeo, Fukuda, Takashi, Fujiwara, Hitoshi, Sato, Shinsuke, Noma, Kazuhiro, Miyata, Hiroshi, Fujita, Takeo, and Kitagawa, Yuko

Subjects
OVERALL survival, NEOADJUVANT chemotherapy, SQUAMOUS cell carcinoma, MOHS surgery, TREATMENT effectiveness
Abstract

Background: Overall survival is considered as one of the most important endpoints of treatment efficacy but often requires long follow-up. This study aimed to determine the validity of recurrence-free survival as a surrogate endpoint for overall survival in patients with surgically resectable advanced oesophageal squamous cell carcinoma (OSCC). Methods: Patients with OSCC who received neoadjuvant cisplatin and 5-fluorouracil, or docetaxel, cisplatin and 5-fluorouracil, at 58 Japanese oesophageal centres certified by the Japan Esophageal Society were reviewed retrospectively. The correlation between recurrence-free and overall survival was assessed using Kendall's τ. Results: The study included 3154 patients. The 5-year overall and recurrence-free survival rates were 56.6 and 47.7% respectively. The primary analysis revealed a strong correlation between recurrence-free and overall survival (Kendall's τ 0.797, 95% c.i. 0.782 to 0.812) at the individual level. Subgroup analysis showed a positive relationship between a more favourable pathological response to neoadjuvant chemotherapy and a higher τ value. In the meta-regression model, the adjusted R2 value at the institutional level was 100 (95% c.i. 40.2 to 100)%. The surrogate threshold effect was 0.703. Conclusion: There was a strong correlation between recurrence-free and overall survival in patients with surgically resectable OSCC who underwent neoadjuvant chemotherapy, and this was more pronounced in patients with a better response to neoadjuvant chemotherapy. In this retrospective cohort study involving 3154 patients, a strong correlation between recurrence-free and overall survival was established, and this correlation was more pronounced in patients who had a more effective response to neoadjuvant chemotherapy. These findings are beneficial for expediting the development of novel neoadjuvant treatments by shortening the duration of clinical trials. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Epidural versus patient-controlled intravenous analgesia on pain relief and recovery after laparoscopic gastrectomy for gastric cancer: randomized clinical trial.

Author

Kikuchi, Satoru, Matsusaki, Takashi, Mitsuhashi, Toshiharu, Kuroda, Shinji, Kashima, Hajime, Takata, Nobuo, Mitsui, Ema, Kakiuchi, Yoshihiko, Noma, Kazuhiro, Umeda, Yuzo, Morimatsu, Hiroshi, and Fujiwara, Toshiyoshi

Subjects
ANALGESIA, PATIENT-controlled analgesia, ENHANCED recovery after surgery protocol, CLINICAL trials, STOMACH cancer, ABDOMINAL surgery
Abstract

Background Epidural analgesia (EDA) is a main modality for postoperative pain relief in major open abdominal surgery within the Enhanced Recovery After Surgery protocol. However, it remains unclear whether EDA is an imperative modality in laparoscopic gastrectomy (LG). This study examined non-inferiority of patient-controlled intravenous analgesia (PCIA) to EDA in terms of postoperative pain and recovery in patients who underwent LG. Methods In this open-label, non-inferiority, parallel, individually randomized clinical trial, patients who underwent elective LG for gastric cancer were randomized 1:1 to receive either EDA or PCIA after surgery. The primary endpoint was pain score using the Numerical Rating Scale at rest 24 h after surgery, analysed both according to the intention-to-treat (ITT) principle and per protocol. The non-inferiority margin for pain score was set at 1. Secondary outcomes were postoperative parameters related to recovery and adverse events related to analgesia. Results Between 3 July 2017 and 29 September 2020, 132 patients were randomized to receive either EDA (n = 66) or PCIA (n = 66). After exclusions, 64 patients were included in the EDA group and 65 patients in the PCIA group for the ITT analysis. Pain score at rest 24 h after surgery was 1.94 (s.d. 2.07) in the EDA group and 2.63 (s.d. 1.76) in the PCIA group (P = 0.043). PCIA was not non-inferior to EDA for the primary endpoint (difference 0.69, one side 95% c.i. 1.25, P = 0.184) in ITT analysis. Postoperative parameters related to recovery were similar between groups. More EDA patients (21 (32.8%) versus 1 (1.5%), P < 0.001) developed postoperative hypotension as an adverse event. Conclusions PCIA was not non-inferior to EDA in terms of early-phase pain relief after LG. Registration number: UMIN000027643 (https://www.umin.ac.jp/ctr/index-j.htm). [ABSTRACT FROM AUTHOR]

Published
2024
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39. Recurrence-free survival as a surrogate for overall survival in esophageal squamous cell carcinoma: Nationwide real-world data from Japan.

Author

Okui, Jun, Nagashima, Kengo, Matsuda, Satoru, Sato, Yasunori, Okamura, Akihiko, Kawakubo, Hirofumi, Muto, Manabu, Kakeji, Yoshihiro, Kono, Koji, TAKEUCHI, HIROYA, Watanabe, Masayuki, Doki, Yuichiro, Bamba, Takeo, Fukuda, Takashi, Fujiwara, Hitoshi, Sato, Shinsuke, Noma, Kazuhiro, Miyata, Hiroshi, Fujita, Takeo, and Kitagawa, Yuko

Published
2024
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40. A randomized controlled phase III trial comparing thoracoscopic esophagectomy and open esophagectomy for thoracic esophageal cancer: JCOG1409 (MONET trial).

Author

TAKEUCHI, HIROYA, Ando, Masahiko, Tsubosa, Yasuhiro, Kikuchi, Hirotoshi, Kawakubo, Hirofumi, Noma, Kazuhiro, Ueno, Masaki, Tsushima, Takahiro, Bamba, Takeo, Fujita, Takeo, Hamai, Yoichi, Kakishita, Tomokazu, Daiko, Hiroyuki, Koyanagi, Kazuo, Matsuda, Satoru, Kato, Ken, Sasaki, Keita, Kita, Ryosuke, Machida, Ryunosuke, and Kitagawa, Yuko

Published
2024
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49. Case of robot‐assisted salvage surgery for esophageal cancer with a mediastinal fistula after definitive chemoradiotherapy.

Author

Kadowaki, Daisuke, Noma, Kazuhiro, Hashimoto, Masashi, Maeda, Naoaki, Tanabe, Shunsuke, Shirakawa, Yasuhiro, and Fujiwara, Toshiyoshi

Subjects
*SURGICAL robots, *ESOPHAGEAL cancer, *ONCOLOGIC surgery, *ESOPHAGEAL fistula, *SURGICAL complications, *CHEMORADIOTHERAPY
Abstract

Salvage surgery for esophageal cancer after definitive chemoradiotherapy (dCRT) is effective, but it is associated with a high rate of perioperative complications. The indications for robot‐assisted minimally invasive esophagectomy (RAMIE) are expanding. However, there are few reports of salvage RAMIE. A 73‐year‐old man was referred to our hospital for residual esophageal cancer with a mediastinal fistula after dCRT. The perioperative diagnosis was T3N1M0‐Stage III, and the salvage RAMIE was performed. Although the dissection was difficult due to fibrosis caused by dCRT and the esophageal mediastinal fistula, RAMIE was performed safely with no complications. Multiple features of RAMIE contributed to stable surgery. The monopolar dissection is effective for hard scar tissue caused by CRT and inflammation. [ABSTRACT FROM AUTHOR]

Published
2023
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