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Our research aims to identify approaches to promoting further education resources. Staff development is the main indicator of employee productivity and a productive "motivation factor" of increasing work initiative, strengthening the personnel behind the enterprise. Modern production places high demands on working personnel and the system of their training and retraining in the conditions of market relations. In the process of scientific and technological progress, some specialties disappear, others arise. All this creates a need for the latest forms of training, retraining and advanced training of employees. In this regard, educational institutions are faced with the need to find potential clients who need to meet the need for professional growth. Competition between organizations in the education market has intensified due to the pandemic. All this makes it relevant to use modern technologies in attracting the attention of employers to the opportunities for retraining and advanced training in a particular educational organization.

Absorption capacity and water absorption as the main factors determining the strength and adhesion of waterproofing with stone have not been sufficiently studied. The need to establish this characteristic of the stone is due to the difference in the behavior of its porous system in the dry state and after absorbing moisture from the volume of water and the solution. The article presents a solution to the problem of increasing the effectiveness of waterproofing plastering systems by selecting the optimal technological factors: the type of material, the number of layers and the time of full water saturation.

Oncolytic viruses are genetically engineered viruses that are designed to kill cancer cells while doing minimal damage to normal healthy tissue. After being injected into a tumor, they infect cancer cells, multiply inside them, and when a cancer cell is killed they move on to spread and infect other cancer cells. Chondroitinase ABC (Chase-ABC) is a bacterial enzyme that can remove a major glioma ECM component, chondroitin sulfate glycosoamino glycans from proteoglycans without any deleterious effects in vivo. It has been shown that Chase-ABC treatment is able to promote the spread of the viruses, increasing the efficacy of the viral treatment. In this paper we develop a mathematical model to investigate the effect of the Chase-ABC on the treatment of glioma by oncolytic viruses (OV). We show that the model's predictions agree with experimental results for a spherical glioma. We then use the model to test various treatment options in the heterogeneous microenvironment of the brain. The model predicts that separate injections of OV, one into the center of the tumor and another outside the tumor will result in better outcome than if the total injection is outside the tumor. In particular, the injection of the ECM-degrading enzyme (Chase-ABC) on the periphery of the main tumor core need to be administered in an optimal strategy in order to infect and eradicate the infiltrating glioma cells outside the tumor core in addition to proliferative cells in the bulk of tumor core. The model also predicts that the size of tumor satellites and distance between the primary tumor and multifocal/satellite lesions may be an important factor for the efficacy of the viral therapy with Chase treatment.

Starburst amacrine cells in the macaque retina were studied by electron microscopic immunohistochemistry. We found that these amacrine cells make a type of synapse not described previously; they are presynaptic to axon terminals of bipolar cells. We also confirmed that starburst amacrine cells are presynaptic to ganglion cell dendrites and amacrine cell processes. In order to determine the functions of these synapses, we localized acetylcholine receptors using a monoclonal antibody (mAb210) that recognizes human α3- and α5-containing nicotinic receptors and also antisera against the five known subtypes of muscarinic receptors. The majority of the mAb210-immunoreactive perikarya were amacrine cells and ganglion cells, but a subpopulation of bipolar cells was also labeled. A subset of bipolar cells and a subset of horizontal cells were labeled with antibodies to M3 muscarinic receptors. A subset of amacrine cells, including those that contain cholecystokinin, were labeled with antibodies to M2 receptors. Taken together, these results suggest that acetylcholine can modulate the activity of retinal ganglion cells by multiple pathways. J. Comp. Neurol. 461:76–90, 2003. © 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]