In preparation for a catastrophic earthquake, it is important to plan and implement timely organizational and technical measures to protect the population in the zone of possible destructive seismic impact. In order to quantitatively assess the level of earthquake hazard, the vulnerability of buildings and possible losses among the population, the integral value of individual seismic risk is proposed. For a reliable assessment of individual seismic risk, it is necessary to know the parameters of the possible earthquake source, the macroseismic field, the seismic resistance of buildings caught in the 6-point zone of seismic impact, the seismicity of soils at the base of buildings and possible human losses. The methods currently used to assess individual seismic risk are based on many years of statistical data. We propose an end-to-end calculation-experimental approach to estimate possible losses and individual risk based on actual data on hazard, seismicity and earthquake resistance. [ABSTRACT FROM AUTHOR]