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2. High Frequency of Herpesvirus-Specific Clonotypes in the Human T Cell Repertoire Can Remain Stable over Decades with Minimal Turnover.

Author

Neller, M. A., Burrows, J. M., Rist, M. J., Miles, J. J., and Burrows, S. R.

Subjects
*HERPESVIRUS diseases, *BLOOD banks, *MICROORGANISMS, *T cells, *EPSTEIN-Barr virus
Abstract

High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of life, the dominant clonotypes in the mature peripheral T cell repertoire can alter surprisingly little. [ABSTRACT FROM AUTHOR]

Published
2013
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