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663 results on '"Natarajan, A. T."'

1. Development of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies

Author

Gupta, Pragya, Goswami, Sangam Giri, Kumari, Geeta, Saravanakumar, Vinodh, Bhargava, Nupur, Rai, Akhila Balakrishna, Singh, Praveen, Bhoyar, Rahul C., Arvinden, V. R., Gunda, Padma, Jain, Suman, Narayana, Vanya Kadla, Deolankar, Sayali C., Prasad, T. S. Keshava, Natarajan, Vivek T., Scaria, Vinod, Singh, Shailja, and Ramalingam, Sivaprakash

Published
2024
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2. Kupyaphores are zinc homeostatic metallophores required for colonization of Mycobacterium tuberculosis

Author

Mehdiratta, Kritee, Singh, Shubham, Sharma, Sachin, Bhosale, Rashmi S., Choudhury, Rahul, Masal, Dattatraya P., Manocha, Alzu, Dhamale, Bhushan Dilip, Khan, Naseem, Asokachandran, Vivekanand, Sharma, Pooja, Ikeh, Melanie, Brown, Amanda C., Parish, Tanya, Ojha, Anil K., Michael, Joy Sarojini, Faruq, Mohammed, Medigeshi, Guruprasad R., Mohanty, Debasisa, Reddy, D. Srinivasa, Natarajan, Vivek T., Kamat, Siddhesh S., and Gokhale, Rajesh S.

Published
2022

3. Distinct melanocyte subpopulations defined by stochastic expression of proliferation or maturation programs enable a rapid and sustainable pigmentation response.

Author

Aggarwal, Ayush, Nasreen, Ayesha, Sharma, Babita, Sahoo, Sarthak, Aswin, Keerthic, Faruq, Mohammed, Pandey, Rajesh, Jolly, Mohit K., Singh, Abhyudai, Gokhale, Rajesh S., and Natarajan, Vivek T.

Subjects
HUMAN skin color, GENE regulatory networks, HISTONE acetylation, GENE expression, CHROMATOPHORES
Abstract

The ultraviolet (UV) radiation triggers a pigmentation response in human skin, wherein, melanocytes rapidly activate divergent maturation and proliferation programs. Using single-cell sequencing, we demonstrate that these 2 programs are segregated in distinct subpopulations in melanocytes of human and zebrafish skin. The coexistence of these 2 cell states in cultured melanocytes suggests possible cell autonomy. Luria–Delbrück fluctuation test reveals that the initial establishment of these states is stochastic. Tracking of pigmenting cells ascertains that the stochastically acquired state is faithfully propagated in the progeny. A systemic approach combining single-cell multi-omics (RNA+ATAC) coupled to enhancer mapping with H3K27 acetylation successfully identified state-specific transcriptional networks. This comprehensive analysis led to the construction of a gene regulatory network (GRN) that under the influence of noise, establishes a bistable system of pigmentation and proliferation at the population level. This GRN recapitulates melanocyte behaviour in response to external cues that reinforce either of the states. Our work highlights that inherent stochasticity within melanocytes establishes dedicated states, and the mature state is sustained by selective enhancers mark through histone acetylation. While the initial cue triggers a proliferation response, the continued signal activates and maintains the pigmenting subpopulation via epigenetic imprinting. Thereby our study provides the basis of coexistence of distinct populations which ensures effective pigmentation response while preserving the self-renewal capacity. Ultraviolet (UV) radiation triggers a pigmentation response in human skin, wherein melanocytes rapidly activate divergent maturation and proliferation programs. Here, the authors identify distinct melanocyte sub-populations with maturation and proliferation programs initiated by stochastic gene expression in response to external pigmentation cues such as UV. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Polyketide Quinones Are Alternate Intermediate Electron Carriers during Mycobacterial Respiration in Oxygen-Deficient Niches

Author

Anand, Amitesh, Verma, Priyanka, Singh, Anil Kumar, Kaushik, Sandeep, Pandey, Rajesh, Shi, Ce, Kaur, Harneet, Chawla, Manbeena, Elechalawar, Chandra Kumar, Kumar, Dhirendra, Yang, Yong, Bhavesh, Neel S., Banerjee, Rajkumar, Dash, Debasis, Singh, Amit, Natarajan, Vivek T., Ojha, Anil K., Aldrich, Courtney C., and Gokhale, Rajesh S.

Published
2015
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30. In this issue

Author

Natarajan, A. T. and Kesavan, P. C.

Published
2005

43. Effects of Si on the Ductile‐to‐Brittle Transition Behavior of As‐Cast Advanced High‐Strength Steels.

Author

Giacomin, Rafael Coura, Bollinger, Andrea Lynn, Komolwit, Piyamanee, Natarajan, Thinium T., Pistorius, Petrus Christiaan, and Webler, Bryan A.

Subjects
BRITTLE fractures, STEEL, CONTINUOUS casting, LOW temperatures, EMBRITTLEMENT, CRACK propagation
Abstract

High Si concentrations in third‐generation advanced high‐strength steels (AHSS) are known to cause cracking in continuous cast slabs during cooling at temperatures below 300 °C. To investigate the mechanism connecting Si to this embrittlement, impact toughness tests are conducted on as‐cast Fe–0.2C–3.0Mn steels with 0.5, 1.5, and 3.0 wt% Si at temperatures between 100 and 400 °C. The propagation path of the cracks through the microstructure of the specimens is examined. The ductile‐to‐brittle transition (DBT) behaviors of the three steels are compared. Higher Si concentrations raise the DBT temperature of the steels. The influence of Si on both solid‐solution strengthening and autotempering during cooling likely contributes to this by increasing the hardness of these as‐cast microstructures. In addition, the precipitation of pro‐eutectoid ferrite (αPE), which is promoted by higher Si concentrations, significantly lowers the upper shelf energy of the DBT curve. The αPE phase also alters the propagation path of brittle fracture in the specimens, potentially contributing to the increase in DBT temperature. The increase in DBT temperature and decrease in upper shelf energy may contribute to the as‐cast AHSS slab embrittlement at low temperatures observed in the industry. [ABSTRACT FROM AUTHOR]

Published
2022
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