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221 results on '"Naphthacenes metabolism"'

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1. Biological evaluation and spectral characterization of a novel tetracenomycin X congener.

2. Biosynthesis of Diverse Type II Polyketide Core Structures in Streptomyces coelicolor M1152.

3. An Emerging Pathway of Doxorubicin Cardiotoxicity Mediated through CYP2J2.

4. The complete genome sequence of the actinobacterium Streptomyces glaucescens GLA.O (DSM 40922) carrying gene clusters for the biosynthesis of tetracenomycin C, 5`-hydroxy streptomycin, and acarbose.

5. One-Pot Combinatorial Biosynthesis of Glycosylated Anthracyclines by Cocultivation of Streptomyces Strains Producing Aglycones and Nucleotide Deoxysugars.

6. High level of antibiotic production in a double polyphosphate kinase and phosphate-binding protein mutant of Streptomyces lividans.

7. Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase.

8. High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain.

9. Kinetic study of the quenching reaction of singlet oxygen by common synthetic antioxidants (tert-butylhydroxyanisol, tert-di-butylhydroxytoluene, and tert-butylhydroquinone) as compared with alpha-tocopherol.

10. Doxorubicinolone formation and efflux: a salvage pathway against epirubicin accumulation in human heart.

11. Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.

12. Singlet oxygen quenching effects of phosphatidylcholine in emulsion containing sunflower oil.

13. Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways.

14. Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids.

15. Doxorubicin levels in the serum and ascites of patients with ovarian cancer.

16. Geminal bismethylation prevents polyketide oxidation and dimerization in the benastatin pathway.

17. Crystal structure of XC5357 from Xanthomonas campestris: a putative tetracenomycin polyketide synthesis protein adopting a novel cupin subfamily structure.

18. Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses.

19. Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanism.

20. AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.

21. Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.

22. Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.

23. Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificity.

24. Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.

25. Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products.

26. Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.

27. Enhanced production of microbial metabolites in the presence of dimethyl sulfoxide.

28. Generation of hybrid elloramycin analogs by combinatorial biosynthesis using genes from anthracycline-type and macrolide biosynthetic pathways.

29. The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice.

30. Electrostatic and non-electrostatic contributions to the binding free energies of anthracycline antibiotics to DNA.

31. Identification of a monooxygenase from Streptomyces coelicolor A3(2) involved in biosynthesis of actinorhodin: purification and characterization of the recombinant enzyme.

32. Isolation of new anthracyclines 10-O-rhodosaminyl beta-rhodomycinone and beta-isorhodomycinone from mild-acid treated culture of obelmycin-producing Streptomyces violaceus.

33. Reductive activation of doxorubicin by xanthine dehydrogenase from EMT6 mouse mammary carcinoma tumors.

34. Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity.

35. Engineered biosynthesis of novel polyketides: regiospecific methylation of an unnatural substrate by the tcmO O-methyltransferase.

36. Semiquinone free radical formation by daunorubicin aglycone incorporated into the cellular membranes of intact Chinese hamster ovary cells.

37. Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tü2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.

38. Triple hydroxylation of tetracenomycin A2 to tetracenomycin C in Streptomyces glaucescens. Overexpression of the tcmG gene in Streptomyces lividans and characterization of the tetracenomycin A2 oxygenase.

39. Interactions of adriamycin aglycones with mitochondria may mediate adriamycin cardiotoxicity.

40. Molecular cloning and characterization of the aklavinone 11-hydroxylase gene of Streptomyces peucetius subsp. caesius ATCC 27952.

41. Isolation and characterization of aclacinomycin A-non-producing Streptomyces galilaeus (ATCC 31615) mutants.

42. Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus.

43. Nucleotide sequence of the aknA region of the aklavinone biosynthetic gene cluster of Streptomyces galilaeus.

44. Polyketide biosynthesis: molecular recognition or genetic programming?

45. Overproduction of the acyl carrier protein component of a type II polyketide synthase stimulates production of tetracenomycin biosynthetic intermediates in Streptomyces glaucescens.

46. The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.

47. Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.

48. Kinetics of glucose oxidase catalyzed electron transfer mediated by sulfur and selenium compounds.

49. Isolation and structural elucidation of tetracenomycin F2 and tetracenomycin F1: early intermediates in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.

50. Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.

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