259 results on '"Naniche, Denise"'
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2. High mortality following early initiation of antiretroviral therapy in infants living with HIV from three African countries
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Tagarro, Alfredo, Domínguez-Rodríguez, Sara, Cotton, Mark, Otwombe, Kennedy, Klein, Nigel, Lain, Maria Grazia, Nhampossa, Tacilta, Maiga, Almoustapha Issiaka, Barnabas, Shaun, Vaz, Paula, Violari, Avy, Fernández-Luis, Sheila, Behuhuma, Osee, Sylla, Mariam, López-Varela, Elisa, Naniche, Denise, Janse-Van-Rensburg, Anita, Liberty, Afaaf, Ramsagar, Nastassja, Smit, Theresa, Makhari, Senamile, Ismael, Nalia, Giaquinto, Carlo, Rossi, Paolo, Kuhn, Louise, Palma, Paolo, Spyer, Moira, Lichterfeld, Mathias, Nastuoli, Eleni, Giannuzzi, Viviana, Ballesteros, Alvaro, Cotugno, Nicola, Morrocchi, Elena, Oletto, Andrea, Traoré, Fatoumata Tata, Dobbels, Els, Akhalwaya, Yasmeen, Ording-Jespersen, Gregory, Foster, Caroline, Rabie, Helena, Amuge, Pauline, Brehin, Camille, Pahwa, Savita, Coulibaly, Yacouba Aba, and Rojo, Pablo
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- 2024
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3. Reasons for non-disclosure of HIV-Positive status to healthcare providers: a mixed methods study in Mozambique
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Fuente-Soro, Laura, Figueroa-Romero, Antía, Fernández-Luis, Sheila, Augusto, Orvalho, López-Varela, Elisa, Bernardo, Edson, Saura-Lázaro, Anna, Vaz, Paula, Wei, Stanley C., Kerndt, Peter R., Nhampossa, Tacilta, and Naniche, Denise
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- 2023
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4. Vaccines and therapeutics for immunocompromised patients with COVID-19
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Shoham, Shmuel, Batista, Carolina, Ben Amor, Yanis, Ergonul, Onder, Hassanain, Mazen, Hotez, Peter, Kang, Gagandeep, Kim, Jerome H., Lall, Bhavna, Larson, Heidi J., Naniche, Denise, Sheahan, Timothy, Strub-Wourgaft, Nathalie, Sow, Samba O., Wilder-Smith, Annelies, Yadav, Prashant, and Bottazzi, Maria Elena
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- 2023
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5. Field performance and cost‐effectiveness of a point‐of‐care triage test for HIV virological failure in Southern Africa
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Saura‐Lázaro, Anna, Bock, Peter, Van Den Bogaart, Erika, Vliet, Jessie, Granés, Laura, Nel, Kerry, Naidoo, Vikesh, Scheepers, Michelle, Saunders, Yvonne, Leal, Núria, Ramponi, Francesco, Paulussen, René, Wit, Tobias Rinke, Naniche, Denise, and López‐Varela, Elisa
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Cost benefit analysis ,Viremia -- Measurement ,Triage (Medicine) -- Evaluation ,HIV infection -- Development and progression -- Care and treatment ,Cost benefit analysis ,Health - Abstract
: Introduction: Antiretroviral therapy (ART) monitoring using viral load (VL) testing is challenging in high‐burden, limited‐resources settings. Chemokine IP‐10 (interferon gamma‐induced protein 10) strongly correlates with human immunodeficiency virus (HIV) VL. Its determination could serve to predict virological failure (VF) and to triage patients requiring VL testing. We assessed the field performance of a semi‐quantitative IP‐10 lateral flow assay (LFA) for VF screening in South Africa, and the cost‐effectiveness of its implementation in Mozambique. Methods: A cross‐sectional study was conducted between June and December 2021 in three primary health clinics in the Western Cape. Finger prick capillary blood was collected from adults on ART for ≥1 year for direct application onto the IP‐10 LFA (index test) and compared with a plasma VL result ≤1 month prior (reference test). We estimated the area under the receiver operating characteristic curves (AUC), sensitivity and specificity, to evaluate IP‐10 LFA prediction of VF (VL>1000 copies/ml). A decision tree model was used to investigate the cost‐effectiveness of integrating IP‐10 LFA combined with VL testing into the current Mozambican ART monitoring strategy. Averted disability‐adjusted life years (DALYs) and HIV acquisitions, and incremental cost‐effectiveness ratios were estimated. Results: Among 209 participants (median age 38 years and 84% female), 18% had VF. Median IP‐10 LFA values were higher among individuals with VF compared to those without (24.0 vs. 14.6; p Conclusions: The IP‐10 LFA is an effective VF triage test for routine ART monitoring. Combining a highly sensitive, low‐cost IP‐10 LFA‐based screening with targeted VL confirmatory testing could result in significant healthcare quality improvements and cost savings in settings with limited access to VL testing., INTRODUCTION For people living with human immunodeficiency virus (PLHIV) on antiretroviral therapy (ART), viral load (VL) testing is the gold standard approach to timely monitor treatment effectiveness, identify virological failure [...]
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- 2023
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6. Costs and cost-effectiveness of HIV counselling and testing modalities in Southern Mozambique
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Choo, Jun Hao, Lopez-Varela, Elisa, Fuente-Soro, Laura, Augusto, Orvalho, Sacoor, Charfudin, Nhacolo, Ariel, Wei, Stanley, Naniche, Denise, Thomas, Ranjeeta, and Sicuri, Elisa
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- 2022
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7. Optimizing the World Health Organization algorithm for HIV vertical transmission risk assessment by adding maternal self-reported antiretroviral therapy adherence
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Fernández-Luis, Sheila, Lain, Maria Grazia, Serna-Pascual, Miquel, Domínguez-Rodríguez, Sara, Kuhn, Louise, Liberty, Afaaf, Barnabas, Shaun, Lopez-Varela, Elisa, Otwombe, Kennedy, Danaviah, Siva, Nastouli, Eleni, Palma, Paolo, Cotugno, Nicola, Spyer, Moira, Giannuzzi, Viviana, Giaquinto, Carlo, Violari, Avy, Cotton, Mark F., Nhampossa, Tacilta, Klein, Nigel, Ramsagar, Nastassja, van Rensburg, Anita Janse, Behuhuma, Osee, Vaz, Paula, Maiga, Almoustapha Issiaka, Oletto, Andrea, Naniche, Denise, Rossi, Paolo, Rojo, Pablo, and Tagarro, Alfredo
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- 2022
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8. Beyond viral suppression: Quality of life among stable ART clients in a differentiated service delivery intervention in Tanzania
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Okere, Nwanneka Ebelechukwu, Censi, Veronica, Machibya, Clementina, Costigan, Kathleen, Katambi, P., Martelli, Giulia, de Klerk, Josien, Hermans, Sabine, Gomez, Gabriela B., Pozniak, Anton, de Wit, Tobias Rinke, and Naniche, Denise
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- 2022
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9. Occupational barriers to HIV care in female sex workers living with HIV : structural or community solutions?
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Tokar, Anna and Naniche, Denise
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- 2020
10. Global public health security and justice for vaccines and therapeutics in the COVID-19 pandemic
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Hotez, Peter J., Batista, Carolina, Amor, Yanis Ben, Ergonul, Onder, Figueroa, J Peter, Gilbert, Sarah, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Kaslow, David C., Kim, Jerome H., Lall, Bhavna, Larson, Heidi, Naniche, Denise, Sheahan, Timothy, Shoham, Shmuel, Wilder-Smith, Annelies, Sow, Samba O., Strub-Wourgaft, Nathalie, Yadav, Prashant, and Bottazzi, Maria Elena
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- 2021
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11. Operation Warp Speed: implications for global vaccine security
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Kim, Jerome H, Hotez, Peter, Batista, Carolina, Ergonul, Onder, Figueroa, J Peter, Gilbert, Sarah, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Lall, Bhavna, Larson, Heidi, Naniche, Denise, Sheahan, Timothy, Shoham, Shmuel, Wilder-Smith, Annelies, Strub-Wourgaft, Nathalie, Yadav, Prashant, and Bottazzi, Maria Elena
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- 2021
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12. Enhancing HIV positivity yield in southern Mozambique: The effect of a Ministry of Health training module in targeted provider-initiated testing and counselling.
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Saura-Lázaro, Anna, Fernández-Luis, Sheila, Nhampossa, Tacilta, Fuente-Soro, Laura, López-Varela, Elisa, Bernardo, Edson, Augusto, Orvalho, Sánchez, Teresa, Vaz, Paula, Wei, Stanley C., Kerndt, Peter, Honwana, Nely, Young, Peter, Amane, Guita, Boene, Fernando, and Naniche, Denise
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HEALTH information systems ,DIAGNOSIS of HIV infections ,MEDICAL personnel ,RESOURCE-limited settings ,HEALTH facilities ,HIV - Abstract
In Mozambique, targeted provider-initiated HIV testing and counselling (PITC) is recommended where universal PITC is not feasible, but its effectiveness depends on healthcare providers' training. This study aimed to evaluate the effect of a Ministry of Health training module in targeted PITC on the HIV positivity yield, and identify factors associated with a positive HIV test. We conducted a single-group pre-post study between November 2018 and November 2019 in the triage and emergency departments of four healthcare facilities in Manhiça District, a resource-constrained semi-rural area. It consisted of two two-month phases split by a one-week targeted PITC training module ("observation phases"). The HIV positivity yield of targeted PITC was estimated as the proportion of HIV-positive individuals among those recommended for HIV testing by the provider. Additionally, we extracted aggregated health information system data over the four months preceding and following the observation phases to compare yield in real-world conditions ("routine phases"). Logistic regression analysis from observation phase data was conducted to identify factors associated with a positive HIV test. Among the 7,102 participants in the pre- and post-training observation phases (58.5% and 41.5% respectively), 68% were women, and 96% were recruited at triage. In the routine phases with 33,261 individuals (45.8% pre, 54.2% post), 64% were women, and 84% were seen at triage. While HIV positivity yield between pre- and post-training observation phases was similar (10.9% (269/2470) and 11.1% (207/1865), respectively), we observed an increase in yield in the post-training routine phase for women in triage, rising from 4.8% (74/1553) to 7.3% (61/831) (Yield ratio = 1.54; 95%CI: 1.11–2.14). Age (25–49 years) (OR = 2.43; 95%CI: 1.37–4.33), working in industry/mining (OR = 4.94; 95%CI: 2.17–11.23), unawareness of partner's HIV status (OR = 2.50; 95%CI: 1.91–3.27), and visiting a healer (OR = 1.74; 95%CI: 1.03–2.93) were factors associated with a positive HIV test. Including these factors in the targeted PITC algorithm could have increased new HIV diagnoses by 2.6%. In conclusion, providing refresher training and adapting the current targeted PITC algorithm through further research can help reach undiagnosed PLHIV, treat all, and ultimately eliminate HIV, especially in resource-limited rural areas. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Community-based progress indicators for prevention of mother-to-child transmission and mortality rates in HIV-exposed children in rural Mozambique
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Fuente-Soro, Laura, Fernández-Luis, Sheila, López-Varela, Elisa, Augusto, Orvalho, Nhampossa, Tacilta, Nhacolo, Ariel, Bernardo, Edson, Burgueño, Blanca, Ngeno, Bernadette, Couto, Aleny, Guambe, Helga, Tibana, Kwalila, Urso, Marilena, and Naniche, Denise
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- 2021
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14. Consensus statement on the role of health systems in advancing the long-term well-being of people living with HIV
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Lazarus, Jeffrey V., Safreed-Harmon, Kelly, Kamarulzaman, Adeeba, Anderson, Jane, Leite, Ricardo Baptista, Behrens, Georg, Bekker, Linda-Gail, Bhagani, Sanjay, Brown, Darren, Brown, Graham, Buchbinder, Susan, Caceres, Carlos, Cahn, Pedro E., Carrieri, Patrizia, Caswell, Georgina, Cooke, Graham S., Monforte, Antonella d’Arminio, Dedes, Nikos, del Amo, Julia, Elliott, Richard, El-Sadr, Wafaa M., Fuster-Ruiz de Apodaca, María José, Guaraldi, Giovanni, Hallett, Tim, Harding, Richard, Hellard, Margaret, Jaffar, Shabbar, Kall, Meaghan, Klein, Marina, Lewin, Sharon R., Mayer, Ken, Pérez-Molina, Jose A., Moraa, Doreen, Naniche, Denise, Nash, Denis, Noori, Teymur, Pozniak, Anton, Rajasuriar, Reena, Reiss, Peter, Rizk, Nesrine, Rockstroh, Jürgen, Romero, Diana, Sabin, Caroline, Serwadda, David, and Waters, Laura
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- 2021
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15. Vaccinate fast but leave no one behind: a call to action for COVID-19 vaccination in Spain
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Lazarus, Jeffrey V., Bassat, Quique, Crespo, Javier, Fanjul, Gonzalo, Garcia-Basteiro, Alberto L., Hoyos, Marcos López, Mateos, Carlos, Gutierrez, José Muñoz, Naniche, Denise, Oliu-Barton, Miquel, Rabin, Kenneth H., Vilasanjuan, Rafael, Villapol, Sonia, and Martin-Moreno, Jose M.
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- 2021
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16. Clinically relevant thresholds for ultrasensitive HIV drug resistance testing: a multi-country nested case-control study
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Osibogun, Akin, Wallis, Carole L., Nalubwama, Cathy, Letsoalo, Esrom, Senono, Fred, Adelabu, Hameed, Kakooza, Hanipha, Namata, Harriet, Sanne, Ian, Nankya, Immaculate, Menke, Jack, Lange, Joep M.A., Sigaloff, Kim C.E., Mandaliya, Kishor, Hardman, Margaret, Siwale, Margaret, de Jager, Marleen, Dolan, Marian, Botes, Mariette E., O'Mello, Martin, Wellington, Maureen, Mutebi, Miiro, Nakitto, Miriam, Labib, Moheb, Pakker, Nadine, Ondoa, Pascale, Mugyenyi, Peter, Ive, Prudence, Nakanjako, Ritah, Schuurman, Rob, Lüthy, Ruedi, Balinda, Sheila N., Akanmu, Sulaimon, Boender, T. Sonia, Adeyemo, Titilope A., Rodoye, Tope, Stevens, Wendy S., Namala, Winnie, Inzaule, Seth C, Hamers, Raph L, Noguera-Julian, Marc, Casadellà, Maria, Parera, Mariona, Kityo, Cissy, Steegen, Kim, Naniche, Denise, Clotet, Bonaventura, Rinke de Wit, Tobias F, and Paredes, Roger
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- 2018
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17. Interferon-γ–Inducible Protein 10 (IP-10) as a Screening Tool to Optimize Human Immunodeficiency Virus RNA Monitoring in Resource-Limited Settings
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Pastor, Lucía, Casellas, Aina, Rupérez, María, Carrillo, Jorge, Maculuve, Sonia, Jairoce, Chenjerai, Paredes, Roger, Blanco, Julià, and Naniche, Denise
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- 2017
18. Intersectionality and health-related stigma: insights from experiences of people living with stigmatized health conditions in Indonesia
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Rai, Sarju Sing, Peters, Ruth M. H., Syurina, Elena V., Irwanto, Irwanto, Naniche, Denise, and Zweekhorst, Marjolein B. M.
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- 2020
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19. Achieving global equity for COVID-19 vaccines: Stronger international partnerships and greater advocacy and solidarity are needed
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Figueroa, J Peter, Hotez, Peter J., Batista, Carolina, Ben Amor, Yanis, Ergonul, Onder, Gilbert, Sarah, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Kaslow, David C., Kim, Jerome H., Lall, Bhavna, Larson, Heidi, Naniche, Denise, Sheahan, Timothy, Shoham, Shmuel, Wilder-Smith, Annelies, Sow, Samba O., Strub-Wourgaft, Nathalie, Yadav, Prashant, and Bottazzi, Maria Elena
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World health -- Social aspects -- Management ,International cooperation -- Health aspects ,Health care disparities -- Prevention ,Company business management ,Company distribution practices ,Biological sciences - Abstract
Author(s): J Peter Figueroa 1,*, Peter J. Hotez 2, Carolina Batista 3, Yanis Ben Amor 4, Onder Ergonul 5, Sarah Gilbert 6, Mayda Gursel 7, Mazen Hassanain 8, Gagandeep Kang [...]
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- 2021
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20. Discordant retention of HIV-infected mothers and children: Evidence for a family-based approach from Southern Mozambique
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Nhampossa, Tacilta, Fernandez, Sheila, Augusto, Orvalho, Fuente-Soro, Laura, Maculuve, S.ó.nia, Bernardo, Edson, Saura, Anna, Casellas, Aina, Gonzalez, Raquel, Ruperez, Maria, Karajeans, Esmeralda, Vaz, Paula, Menendez, Clara, Buck, W. Chris, Naniche, Denise, and Lopez-Varela, Elisa
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- 2020
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21. Loss to follow-up and opportunities for reengagement in HIV care in rural Mozambique: A prospective cohort study
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Fuente-Soro, Laura, López-Varela, Elisa, Augusto, Orvalho, Bernardo, Edson Luis, Sacoor, Charfudin, Nhacolo, Ariel, Ruiz-Castillo, Paula, Alfredo, Charity, Karajeanes, Esmeralda, Vaz, Paula, and Naniche, Denise
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- 2020
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22. Pediatric HIV Care Cascade in Southern Mozambique: Missed Opportunities for Early ART and Re-engagement in Care
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Fernández-Luis, Sheila, Nhampossa, Tacilta, Fuente-Soro, Laura, Augusto, Orvalho, Casellas, Aina, Bernardo, Edson, Ruperez, Maria, Gonzalez, Raquel, Maculuve, Sonia, Saura-Lázaro, Anna, Menendez, Clara, Naniche, Denise, and Lopez-Varela, Elisa
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- 2020
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23. Monitoring progress towards the first UNAIDS target: understanding the impact of people living with HIV who re-test during HIV-testing campaigns in rural Mozambique
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Fuente-Soro, Laura, Lopez-Varela, Elisa, Augusto, Orvalho, Sacoor, Charfudin, Nhacolo, Ariel, Honwana, Nely, Karajeanes, Esmeralda, Vaz, Paula, and Naniche, Denise
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HIV tests -- Usage -- Analysis ,Antiretroviral agents -- Dosage and administration ,Wellness programs -- Analysis ,Health - Abstract
Introduction: Awareness of HIV-infection goes beyond diagnosis, and encompasses understanding, acceptance, disclosure and initiation of the HIV-care. We aimed to characterize the HIV-positive population that underwent repeat HIV-testing without disclosing their serostatus and the impact on estimates of the first UNAIDS 90 target. Methods: This analysis was nested in a prospective cohort established in southern Mozambique which conducted three HIV-testing modalities: voluntary counselling and testing (VCT), provider-initiated counselling and testing (PICT) and home-based testing (HBT). Participants were given the opportunity to self-report their status to lay counsellors and HIV-positive diagnoses were verified for previous enrolment in care. This study included 1955 individuals diagnosed with HIV through VCT/PICT and 11,746 participants of a HBT campaign. Those who did not report their serostatus prior to testing, and were found to have a previous HIV-diagnosis, were defined as non-disclosures. Venue-stratified descriptive analyses were performed and factors associated with non-disclosure were estimated through log-binomial regression. Results: In the first round of 2500 adults randomized for HBT, 1725 were eligible for testing and 18.7% self-reported their HIV-positivity. Of those tested with a positive result, 38.9% were found to be non-disclosures. Similar prevalence of non-disclosures was found in clinical-testing modalities, 29.4% (95% CI 26.7 to 32.3) for PICT strategy and 13.0% (95% CI 10.9 to 15.3) for VCT. Prior history of missed visits (adjusted prevalence ratio (APR) 4.2, 95% CI 2.6 to 6.8), younger age (APR 2.5, 95% CI 1.4 to 4.4) and no prior history of treatment ((APR) 1.4, 95% CI 1.0 to 2.1) were significantly associated with non-disclosure as compared to patients who self-reported. When considering non-disclosures as people living with HIV (PLWHIV) aware of their HIV-status, the proportion of PLWHIV aware increased from 78.3% (95% CI 74.2 to 81.6) to 86.8% (95% CI 83.4 to 89.6). Conclusion: More than one-third of individuals testing HIV-positive did not disclose their previous positive HIV-diagnosis to counsellors. This proportion varied according to testing modality and age. In the absence of an efficient and non-anonymous tracking system for HIV-testers, repeat testing of non-disclosures leads to wasted resources and may distort programmatic indicators. Developing interventions that ensure appropriate psychosocial support are needed to encourage this population to disclose their status and optimize scarce resources. Keywords: HIV care continuum; Linkage to care; Public health; Awareness; Disclosure; Sub-Saharan Africa; Mozambique; 90-90-90 targets; HIV retesting, 1 | INTRODUCTION In 2014, UNAIDS set the ambitious global strategy of reaching the 90-90-90 targets to end the HIV epidemic by 2020 [1]. This plan established that 90% of [...]
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- 2018
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24. Patient‐incurred costs in a differentiated service delivery club intervention compared to standard clinical care in Northwest Tanzania
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Okere, Nwanneka E., Corball, Lucia, Kereto, Dunia, Hermans, Sabine, Naniche, Denise, De Wit, Tobias F Rinke, and Gomez, Gabriela B.
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Medical care, Cost of -- Comparative analysis ,Clinics -- Comparative analysis ,HIV infection -- Drug therapy ,Health - Abstract
: Introduction: Placing all clients with a positive diagnosis for HIV on antiretroviral therapy (ART) has cost implications both for patients and health systems, which could, in turn, affect feasibility, sustainability and uptake of new services. Patient‐incurred costs are recognized barriers to healthcare access. Differentiated service delivery (DSD) models in general and community‐based care in particular, could reduce these costs. We aimed to assess patient‐incurred costs of a community‐based DSD intervention (clubs) compared to clinic‐based care in the Shinyanga region, Tanzania. Methods: Cross‐sectional survey among stable ART patients (n = 390, clinic‐based; n = 251, club‐based). For each group, we collected socio‐demographic, income and expenditure data between May and August 2019. We estimated direct and indirect patient‐incurred costs. Direct costs included out‐of‐pocket expenditures. Indirect costs included income loss due to time spent during transport, accessing services and off work during illness. Cost drivers were assessed in multivariate regression models. Results: Overall, costs were significantly higher among clinic participants. Costs (USD) per year for clinic versus club were as follows: 11.7 versus 4.17 (p < 0.001) for direct costs, 20.9 versus 8.23 (p < 0.001) for indirect costs and 32.2 versus 12.4 (p < 0.001) for total costs. Time spent accessing care and time spent in illness (hours/year) were 38.3 versus 13.8 (p < 0.001) and 16.0 versus 6.69 (p < 0.001) respectively. The main cost drivers included transportation (clinic vs. club: 67.7% vs. 44.1%) for direct costs and income loss due to time spent accessing care (clinic vs. club: 60.4% vs. 56.7%) for indirect costs. Factors associated with higher total costs among patients attending clinic services were higher education level (coefficient [95% confidence interval]) 20.9 [5.47 to 36.3]) and formal employment (44.2 [20.0 to 68.5). Differences in mean total costs remained significantly higher with formal employment, rural residence, in addition to more frequent visits among clinic participants. The percentage of households classified as having had catastrophic expenditures in the last year was low but significantly higher among clinic participants (10.8% vs. 5.18%, p = 0.014). Conclusions: Costs incurred by patients accessing DSD in the community are significantly lower compared to those accessing standard clinic‐based care. DSD models could improve access, especially in resource‐limited settings., Introduction Placing all clients with a positive diagnosis for HIV on antiretroviral therapy (ART) as currently recommended by WHO has implications both for patients and health systems alike. In sub‐Saharan [...]
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- 2021
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25. Opinion Paper : HIV infection in Eastern and Southern Africa: Highest burden, largest challenges, greatest potential
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Parker, Erica, Judge, Melinda A., Macete, Eusebio, Nhampossa, Tacilta, Dorward, Jienchi, Langa, Denise C., De Schacht, Caroline, Couto, Aleny, Vaz, Paula, Vitoria, Marco, Molfino, Lucas, Idowu, Rachel T., Bhatt, Nilesh, Naniche, Denise, and Le Souëf, Peter N.
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HIV epidemiology ,public health ,risk factors ,vulnerable populations ,prevention and control ,early diagnosis - Abstract
Background:The burden of HIV is especially concerning for Eastern and Southern Africa (ESA), as despite expansion of test-and-treat programmes, this region continues to experience significant challenges resulting from high rates of morbidity, mortality and new infections. Hard-won lessons from programmes on the ground in ESA should be shared. Objectives:This report summarises relevant evidence and regional experts’ recommendations regarding challenges specific to ESA. Method:This commentary includes an in-depth review of relevant literature, progress against global goals and consensus opinion from experts. Results:Recommendations include priorities for essential research (surveillance data collection, key and vulnerable population education and testing, in-country testing trials and evidence-based support services to improve retention in care) as well as research that can accelerate progress towards the prevention of new infections and achieving ambitious global goals in ESA. Conclusion:The elimination of HIV in ESA will require continued investment, commitment to evidence-based programmes and persistence. Local research is critical to ensuring that responses in ESA are targeted, efficient and evaluated.
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- 2023
26. Evolution of the gut microbiome following acute HIV-1 infection
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Rocafort, Muntsa, Noguera-Julian, Marc, Rivera, Javier, Pastor, Lucía, Guillén, Yolanda, Langhorst, Jost, Parera, Mariona, Mandomando, Inacio, Carrillo, Jorge, Urrea, Víctor, Rodríguez, Cristina, Casadellà, Maria, Calle, Maria Luz, Clotet, Bonaventura, Blanco, Julià, Naniche, Denise, and Paredes, Roger
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- 2019
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27. A multinational Delphi consensus to end the COVID-19 public health threat
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Lazarus, Jeffrey V., Romero, Diana, Kopka, Christopher J., Karim, Salim Abdool, Abu-Raddad, Laith J., Almeida, Gisele, Baptista-Leite, Ricardo, Barocas, Joshua A., Barreto, Mauricio L., Bar-Yam, Yaneer, Bassat, Quique, Batista, Carolina, Bazilian, Morgan, Chiou, Shu-Ti, del Rio, Carlos, Dore, Gregory J., Gao, George F., Gostin, Lawrence O., Hellard, Margaret, Jimenez, Jose L., Kang, Gagandeep, Lee, Nancy, Matičič, Mojca, McKee, Martin, Nsanzimana, Sabin, Oliu-Barton, Miquel, Pradelski, Bary, Pyzik, Oksana, Rabin, Kenneth, Raina, Sunil, Rashid, Sabina Faiz, Rathe, Magdalena, Saenz, Rocio, Singh, Sudhvir, Trock-Hempler, Malene, Villapol, Sonia, Yap, Peiling, Binagwaho, Agnes, Kamarulzaman, Adeeba, El-Mohandes, Ayman, Barreto, Mauricio, Abdulla, Salim, Addleman, Sarah, Aghayeva, Gulnara, Agius, Raymond, Ahmed, Mohammed, Ramy, Mohamed Ahmed, Aide, Pedro, Aleman, Soo, Alfred, Jean-Patrick, Ali, Shamim, Aliaga, Jorge, Aloudat, Tammam, Alqahtani, Saleh A., Al-Salman, Jameela, Amuasi, John H., Agrawal, Anurag, Anwar, Wagida, Araujo-Jorge, Tania, Artaza, Osvaldo, Asadi, Leyla, Awuku, Yaw, Baker, Michael, Barberia, Lorena, Bascolo, Ernesto, Belcher, Paul, Bell, Lizett, Benzaken, Adele, Bergholtz, Emil, Bhadelia, Nahid, Bhan, Anant, Bilodeau, Stephane, Bitrán, Ricardo, Bluyssen, Philomena, Bosman, Arnold, Bozza, Fernando A., Brinkmann, Melanie M., Brown, Andrew, Mellado, Bruce, Bukusi, Elizabeth, Bullen, Chris, Buonanno, Giorgio, Burgess, Rochelle, Butler, Matthew, Byakika-Kibwika, Pauline, Cabieses, Baltica, Carlsson, Gunilla, Cascini, Fidelia, Chabala, Chishala, Chakroun, Mohamed, Cheng, null, Chetty, Agnes, Chumachenko, Dmytro, Consalves, Gregg, Conway Morris, Andrew, Cordie, Ahmed, Corrah, Tumani, Crabtree-Ramírez, Brenda, Dashdorj, Naranjargal, Davidovitch, Nadav, de Souza, Luis Eugenio, Dhariwal, Akshay Chand, Druică, Elena, Ergonul, Onder, Erondu, Ngozi A., Essar, Mohammad Yasir, Ewing, Andrew, Fanjul, Gonzalo, Feierstein, Daniel, Feigl-Ding, Eric, Figueroa, Ramon, Figueroa, John Peter, Fisher, Dale, Flores, Walter, Forero-Peña, David A., Frumkin, Howard, Gamkrelidze, Amiran, Gandhi, Monica, Garcia, Patricia, Garcia-Basteiro, Alberto L., García-Sastre, Adolfo, Garg, Suneela, Gbeasor-Komlanvi, null, Gershenson, Carlos, Gilada, Ishwar, Giovanella, Ligia, González, Marino, Green, Manfred S., Greenhalgh, Trisha, Griffin, Paul, Griffin, Stephen, Grinsztejn, Beatriz, Anand, Tanu, Guerra, Germán, Guinto, Renzo, Gujski, Mariusz, Guner, Rahmet, Hamdy, Adam, Hâncean, Marian-Gabriel, Haniffa, Abusayeed, Hartigan-Go, Kenneth Y., Hassan, Hoda K., Hay, Simon I., Heino, Matti T. J., Hel, Zdenek, Hotez, Peter, Hu, Jia, Hukić, Mirsada, IJsselmuiden, Carel, Iroko, Davidson, Iskarous, Maged, Izugbara, Chimaraoke, Jacobs, Choolwe, Jadad, Alejandro R., Jehan, Fyezah, Jordan, Ayana, Jroundi, Imane, Kain, Kevin, Kamberi, Fatjona, Karamov, Eduard, Karan, Abraar, Katz, Rebecca, Katzourakis, Aris, Kazembe, Abigail, Khamis, Faryal, Khamzayev, Komiljon, Khanyola, Judy, Khunti, Kamlesh, Kiguli-Malwadde, Elsie, Kim, Woo Joo, Kirenga, Bruce J., Klimovský, Daniel, Kmush, Brittany L., Knaul, Felicia, Kogevinas, Manolis, Kristensen, Frederik, Kumar, Dinesh, Kumar, Raman, Kvalsvig, Amanda, Lacerda, Marcus V., Lal, Arush, Lawton, Tom, Lemery, Jay, Leonardi, Anthony J., Li, Yuguo, Löttvall, Jan, Lounis, Mohamed, Maceira, Daniel, MacIntyre, C. Raina, Madani, Azzeddine, Magiorkinis, Gkikas, Malekzadeh, Reza, Choisy, Marc, Marcelin, Jasmine R., Marks, Guy B., Marr, Linsey, Marrazzo, Jeanne, Martina, Antonieta, Martín-Moreno, José M., Mateos, Carlos, Mayxay, Mayfong, Mazarati, Jean Bapiste, Mboup, Souleymane, McDonald, Jennifer, McMillan, Faye, Mechili, Enkeleint, Medici, Andre, Davis, Sarah L. M., Meier, Petra, Memish, Ziad A., Menon, Jaideep, Menon, Purnima, Mesiano-Crookston, Jonathan, Michie, Susan, Mikolasevic, Ivana, Milicevic, Ognjen, Mishra, Asit Kumar, Mohamed, Rahma, Mokdad, Ali H., Monroy-Valle, Michele, Morawska, Lidia, Moschos, Sterghios A., Motawea, Karam, Mousavi, Sayed Hamid, Mumtaz, Ghina, Munene, Peter K., Muñoz Almagro, Carmen, Muriuki, Janet, Muyingo, Sylvia, Naniche, Denise, Naylor, C. David, Ndembi, Nicaise, Nemec, Juraj, Nesteruk, Igor, Ngaruiya, Christine, Nguyen, Hung, Nikolova, Dafina, Nitzan, Dorit, Norheim, Ole, Noushad, Mohammed, Ntoumi, Francine, Nyborg, Gunhild Alvik, Ochodo, Eleanor, Odabasi, Zekaver, Okwen, Mbah Patrick, Olivia, Keiser, Ong, David S. Y., Opara, Ijeoma, Orozco, Miguel, Oshitani, Hitoshi, Pagel, Christina, Pai, Madhukar, Pálsdóttir, Björg, Papatheodoridis, Georgios, Paraskevis, Dimitrios, Leigh, Jeanna Parsons, Pécoul, Bernard, Peichl, Andreas, Perez-Then, Eddy, Duc, Phuc Pham, Philippe, Cécile, Pineda Rojas, Andrea, Pladsen, Courtney, Pozniak, Anton, Quiroga, Rodrigo, Qureshi, Huma, Rampal, Sanjay, Ranney, Megan, Rathe, Laura, Ratzan, Scott, Raventos, Henriette, Rees, Helen, Reis, Renata, Ricciardi, Walter, Rizk, Nesrine, Robalo, Magda, Robertson, Eleanor, Robinson, Leanne, Rokx, Casper, Ros, Tamsin, Røttingen, John-Arne, Rubin, Meir, Ruxrungtam, Kiat, Sadirova, Shakhlo, Saha, Senjuti, Salgado, Nelly, Sanchez, Lizet, Sangaramoorthy, Thurka, Santamaria-Ulloa, Carolina, Santos, Renata, Sawaf, Bisher, Schneider, Matthias F., Schooley, Robert T., Sener, Alper, Sepulveda, Jaime, Shah, Jaffer, Shibani, Mosa, Shoib, Sheikh, Sikazwe, Izukanji, Šimaitis, Aistis, Gill, Amandeep Singh, Skhvitaridze, Natia, Sokolović, Milka, Solomon, Roma, Solórzano, Xavier, Springer, Sandra A., Šrol, Jakub, Staines, Anthony, Stelfox, Henry T., Strathdee, Steffanie, Sulaiman, Lokman Hakim, Sutton, Brett, Svanæs, Dag, Swed, Sarya, Sypsa, Vana, Sørensen, Kristine, Tajudeen, Raji, Tan, Amy, Tang, Julian, Tanner, Marcel, Sethi, Tavpritesh, Temmerman, Marleen, Than, Kyu Kyu, Tinto, Halidou, Tomètissi, Sênoudé Pacôme, Torres, Irene, Tshering, null, Tsiodras, Sotirios, Tsofa, Benjamin, Vahlne, Anders, Vargas, Juan Rafael, Bernal, Ivan Dario Velez, Ventura, Deisy, Vilasanjuan, Rafael, Vipond, Joe, Wamala-Andersson, Sarah, Wargocki, Pawel, West, Robert, Weyand, Angela, White, Trenton M., Wolff, Guntram, Yao, Maosheng, Yates, Christian A., Yeboah, Georgina, Yee-Sin, Leo, Yi, Siyan, Teo, Yik-Ying, Yong, Poovorawan, Zamora-Mesía, Victor, Øvrehus, Anne, 0000-0001-9618-2299, 0000-0002-4832-9564, 0000-0002-4986-2133, 0000-0003-0790-0506, 0000-0003-0875-7596, 0000-0002-6994-1891, 0000-0002-3869-615X, 0000-0001-5286-4044, 0000-0001-6203-1847, 0000-0002-0121-9683, 0000-0003-1793-6350, 0000-0003-2418-0037, 0000-0002-5095-748X, 0000-0003-4492-3256, 0000-0002-5964-8210, 0000-0002-6779-3151, 0000-0002-8074-4450, Lazarus, Jeffrey V [0000-0001-9618-2299], Romero, Diana [0000-0002-4832-9564], Karim, Salim Abdool [0000-0002-4986-2133], Abu-Raddad, Laith J [0000-0003-0790-0506], Bassat, Quique [0000-0003-0875-7596], Chiou, Shu-Ti [0000-0002-6994-1891], Gao, George F [0000-0002-3869-615X], Gostin, Lawrence O [0000-0001-5286-4044], Jimenez, Jose L [0000-0001-6203-1847], McKee, Martin [0000-0002-0121-9683], Oliu-Barton, Miquel [0000-0003-1793-6350], Pradelski, Bary [0000-0003-2418-0037], Rathe, Magdalena [0000-0002-5095-748X], Trock-Hempler, Malene [0000-0003-4492-3256], Yap, Peiling [0000-0002-5964-8210], Binagwaho, Agnes [0000-0002-6779-3151], Kamarulzaman, Adeeba [0000-0002-8074-4450], Apollo - University of Cambridge Repository, Helsinki Collegium for Advanced Studies, Research Group of Nelli Hankonen, Doctoral Programme in Social Sciences, Academic Disciplines of the Faculty of Social Sciences, RS: CAPHRI - R2 - Creating Value-Based Health Care, International Health, Performance analysis and optimization of LARge Infrastructures and Systems (POLARIS), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Internal Medicine, Medical Microbiology & Infectious Diseases, Veritati - Repositório Institucional da Universidade Católica Portuguesa, and Lazarus J. V., Romero D., Kopka C. J., Karim S. A., Abu-Raddad L. J., Almeida G., Baptista-Leite R., Barocas J. A., Barreto M. L., Bar-Yam Y., et al.
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Pandemics/economics ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences ,COVID-19 Vaccines ,Delphi Technique ,General Science & Technology ,International Cooperation ,Temel Bilimler (SCI) ,ÇOK DİSİPLİNLİ BİLİMLER ,Public Health/economics ,[SHS]Humanities and Social Sciences ,SDG 3 - Good Health and Well-being ,RA0421 Public health. Hygiene. Preventive Medicine ,Medicine and Health Sciences ,Humans ,prevention and control ,human ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Health Education ,Pandemics ,Multidisipliner ,Organizations ,Multidisciplinary ,MULTIDISCIPLINARY SCIENCES ,COVID-19/economics ,Temel Bilimler ,pandemic ,Communication ,Health Policy ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti ,Doğa Bilimleri Genel ,COVID-19 ,3142 Public health care science, environmental and occupational health ,Delphi study ,NATURAL SCIENCES, GENERAL ,N/A ,Public Opinion ,Government ,Natural Sciences (SCI) ,Public Health ,Natural Sciences - Abstract
Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic . Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches , while maintaining proven prevention measures using a vaccines-plus approach that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.
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- 2022
28. Continuum of HIV Care in Rural Mozambique: The Implications of HIV Testing Modality on Linkage and Retention
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Lopez-Varela, Elisa, Fuente-Soro, Laura, Augusto, Orvalho J., Sacoor, Charfudin, Nhacolo, Ariel, Karajeanes, Esmeralda, Vaz, Paula, and Naniche, Denise
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- 2018
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29. Previous antiretroviral drug use compromises standard first-line HIV therapy and is mediated through drug-resistance
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Inzaule, Seth C., Kityo, Cissy M., Siwale, Margaret, Akanmu, Alani Sulaimon, Wellington, Maureen, de Jager, Marleen, Ive, Prudence, Mandaliya, Kishor, Stevens, Wendy, Boender, T. Sonia, Ondoa, Pascale, Sigaloff, Kim C. E., Naniche, Denise, Rinke de Wit, Tobias F., and Hamers, Raph L.
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- 2018
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30. Maternal HIV infection is an important health determinant in non-HIV-infected infants
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Rupérez, María, González, Raquel, Maculuve, Sonia, Quintó, Llorenç, López-Varela, Elisa, Augusto, Orvalho, Vala, Anifa, Nhacolo, Arsénio, Sevene, Esperança, Naniche, Denise, and Menéndez, Clara
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- 2017
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31. Gene dysregulation in acute HIV-1 infection – early transcriptomic analysis reveals the crucial biological functions affected.
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Parker, Erica, Judge, Melinda A., Pastor, Lucia, Fuente-Soro, Laura, Jairoce, Chenjerai, Carter, Kim W., Anderson, Denise, Mandomando, Inácio, Clifford, Holly D., Naniche, Denise, and Neils Le Souëf, Peter
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HIV infections ,CELL cycle regulation ,HIV ,VIRAL load ,TRANSCRIPTOMES ,DNA repair ,BCL genes - Abstract
Introduction: Transcriptomic analyses from early human immunodeficiency virus (HIV) infection have the potential to reveal how HIV causes widespread and lasting damage to biological functions, especially in the immune system. Previous studies have been limited by difficulties in obtaining early specimens. Methods: A hospital symptom-based screening approach was applied in a rural Mozambican setting to enrol patients with suspected acute HIV infection (Fiebig stage I-IV). Blood samples were collected from all those recruited, so that acute cases and contemporaneously recruited, uninfected controls were included. PBMC were isolated and sequenced using RNA-seq. Sample cellular composition was estimated from gene expression data. Differential gene expression analysis was completed, and correlations were determined between viral load and differential gene expression. Biological implications were examined using Cytoscape, gene set enrichment analysis, and enrichment mapping. Results: Twenty-nine HIV infected subjects one month from presentation and 46 uninfected controls were included in this study. Subjects with acute HIV infection demonstrated profound gene dysregulation, with 6131 (almost 13% of the genome mapped in this study) significantly differentially expressed. Viral load was correlated with 1.6% of dysregulated genes, in particular, highly upregulated genes involved in key cell cycle functions, were correlated with viremia. The most profoundly upregulated biological functions related to cell cycle regulation, in particular, CDCA7 may drive aberrant cell division, promoted by overexpressed E2F family proteins. Also upregulated were DNA repair and replication, microtubule and spindle organization, and immune activation and response. The interferome of acute HIV was characterized by broad activation of interferon-stimulated genes with antiviral functions, most notably IFI27 and OTOF. BCL2 downregulation alongside upregulation of several apoptotic trigger genes and downstream effectors may contribute to cycle arrest and apoptosis. Transmembrane protein 155 (TMEM155) was consistently highly overexpressed during acute infection, with roles hitherto unknown. Discussion: Our study contributes to a better understanding of the mechanisms of early HIV-induced immune damage. These findings have the potential to lead to new earlier interventions that improve outcomes. [ABSTRACT FROM AUTHOR]
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- 2023
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32. Reduction of Antimalarial Antibodies by HIV Infection Is Associated With Increased Risk of Plasmodium falciparum Cord Blood Infection
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Naniche, Denise, Serra-Casas, Elisa, Bardají, Azucena, Quintó, Llorenç, Dobaño, Carlota, Sigauque, Betuel, Cisteró, Pau, Chauhan, Virander S., Chitnis, Chetan E., Alonso, Pedro L., Menéndez, Clara, and Mayor, Alfredo
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- 2012
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33. The silent and dangerous inequity around access to COVID-19 testing: A call to action
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Batista, Carolina, Hotez, Peter, Amor, Yanis Ben, Kim, Jerome H, Kaslow, David, Lall, Bhavna, Ergonul, Onder, Figueroa, J Peter, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Larson, Heidi, Naniche, Denise, Sheahan, Timothy, Wilder-Smith, Annelies, Shoham, Shmuel, Sow, Samba O, Yadav, Prashant, Strub-Wourgaft, Nathalie, Loveday, Sarah-Jane, Hannay, Emma, and Bottazzi, Maria Elena
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- 2022
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34. Decrease in Measles Virus-Specific CD4 T Cell Memory in Vaccinated Subjects
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Naniche, Denise, Garenne, Michel, Rae, Chris, Manchester, Marianne, Buchta, Richard, Brodine, Stephanie K., and Oldstone, Michael B. A.
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- 2004
35. Beyond the jab: A need for global coordination of pharmacovigilance for COVID-19 vaccine deployment
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Naniche, Denise, Hotez, Peter, Bottazzi, Maria Elena, Ergonul, Onder, Figueroa, J Peter, Gilbert, Sarah, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Kaslow, David, Kim, Jerome H, Lall, Bhavna, Larson, Heidi, Sheahan, Timothy, Shoham, Shmuel, Wilder-Smith, Annelies, Sow, Samba O., Strub-Wourgaft, Nathalie, Yadav, Prashant, and Batista, Carolina
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- 2021
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36. Urgent needs to accelerate the race for COVID-19 therapeutics
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Batista, Carolina, Shoham, Shmuel, Ergonul, Onder, Hotez, Peter, Bottazzi, Maria Elena, Figueroa, J. Peter, Gilbert, Sarah, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Kaslow, David, Kim, Jerome H., Lall, Bhavna, Larson, Heidi, Naniche, Denise, Sheahan, Timothy, Wilder-Smith, Annelies, Sow, Samba O., Yadav, Prashant, and Strub-Wourgaft, Nathalie
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- 2021
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37. Correcting COVID-19 vaccine misinformation: Lancet Commission on COVID-19 Vaccines and Therapeutics Task Force Members*
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Hotez, Peter, Batista, Carolina, Ergonul, Onder, Figueroa, J Peter, Gilbert, Sarah, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Kim, Jerome H, Lall, Bhavna, Larson, Heidi, Naniche, Denise, Sheahan, Timothy, Shoham, Shmuel, Wilder-Smith, Annelies, Strub-Wourgaft, Nathalie, Yadav, Prashant, and Bottazzi, Maria Elena
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- 2021
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38. Determinants of virological failure and antiretroviral drug resistance in Mozambique
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Rupérez, María, Pou, Christian, Maculuve, Sonia, Cedeño, Samandhy, Luis, Leopoldina, Rodríguez, Judith, Letang, Emilio, Moltó, José, Macete, Eusébio, Clotet, Bonaventura, Alonso, Pedro, Menéndez, Clara, Naniche, Denise, and Paredes, Roger
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- 2015
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39. Prompt HIV diagnosis and antiretroviral treatment in postpartum women is crucial for prevention of mother to child transmission during breastfeeding: Survey results in a high HIV prevalence community in southern Mozambique after the implementation of Option B+
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Fernández-Luis, Sheila, Fuente-Soro, Laura, Nhampossa, Tacilta, Lopez-Varela, Elisa, Augusto, Orvalho, Nhacolo, Ariel, Vazquez, Olalla, Saura-Lázaro, Anna, Guambe, Helga, Tibana, Kwalila, Ngeno, Bernadette, Juga, Adelino José Chingore, Cowan, Jessica Greenberg, Urso, Marilena, and Naniche, Denise
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INFANTS ,VERTICAL transmission (Communicable diseases) ,BREASTFEEDING ,ANTIRETROVIRAL agents ,CHILDBIRTH ,PUERPERIUM ,HIV - Abstract
Objective: World Health Organization recommends promoting breastfeeding without restricting its duration among HIV-positive women on lifelong antiretroviral treatment (ART). There is little data on breastfeeding duration and mother to child transmission (MTCT) beyond 24 months. We compared the duration of breastfeeding in HIV-exposed and HIV-unexposed children and we identified factors associated with postpartum-MTCT in a semi-rural population of Mozambique. Methods: This cross-sectional assessment was conducted from October-2017 to April-2018. Mothers who had given birth within the previous 48-months in the Manhiça district were randomly selected to be surveyed and to receive an HIV-test along with their children. Postpartum MTCT was defined as children with an initial HIV positive result beyond 6 weeks of life who initiated breastfeeding if they had a first negative PCR result during the first 6 weeks of life or whose mother had an estimated date of infection after the child's birth. Cumulative incidence accounting for right-censoring was used to compare breastfeeding duration in HIV-exposed and unexposed children. Fine-Gray regression was used to assess factors associated with postpartum-MTCT. Results: Among the 5000 mother-child pairs selected, 69.7% (3486/5000) were located and enrolled. Among those, 27.7% (967/3486) children were HIV-exposed, 62.2% (2169/3486) were HIV-unexposed and for 10.0% (350/3486) HIV-exposure was unknown. Median duration of breastfeeding was 13.0 (95%CI:12.0–14.0) and 20.0 (95%CI:19.0–20.0) months among HIV-exposed and HIV-unexposed children, respectively (p<0.001). Of the 967 HIV-exposed children, 5.3% (51/967) were HIV-positive at the time of the survey. We estimated that 27.5% (14/51) of the MTCT occurred during pregnancy and delivery, 49.0% (2551) postpartum-MTCT and the period of MTCT remained unknown for 23.5% (12/51) of children. In multivariable analysis, mothers' ART initiation after the date of childbirth was associated (aSHR:9.39 [95%CI:1.75–50.31], p = 0.001), however breastfeeding duration was not associated with postpartum-MTCT (aSHR:0.99 [95%CI:0.96–1.03], p = 0.707). Conclusion: The risk for postpartum MTCT was nearly tenfold higher in women newly diagnosed and/or initiating ART postpartum. This highlights the importance of sustained HIV screening and prompt ART initiation in postpartum women in Sub-Saharan African countries. Under conditions where HIV-exposed infants born to mothers on ART receive adequate PMTCT, extending breastfeeding duration may be recommended. [ABSTRACT FROM AUTHOR]
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- 2022
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40. An autopsy study of maternal mortality in Mozambique: the contribution of infectious diseases
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Menendez, Clara, Romagosa, Cleofe, Ismail, Mamudo R., Carrilho, Carla, Saute, Francisco, Osman, Nafissa, Machungo, Fernanda, Bardaji, Azucena, Quinto, Llorenc, Mayor, Alfredo, Naniche, Denise, Dobano, Carlota, Alonso, Pedro L., and Ordi, Jaume
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Biological sciences - Abstract
Background Maternal mortality is a major health problem concentrated in resource-poor regions. Accurate data on its causes using rigorous methods is lacking, but is essential to guide policymakers and health professionals to reduce this intolerable burden. The aim of this study was to accurately describe the causes of maternal death in order to contribute to its reduction, in one of the regions of the world with the highest maternal mortality ratios. Methods and Findings We conducted a prospective study between October 2002 and December 2004 on the causes of maternal death in a tertiary-level referral hospital in Maputo, Mozambique, using complete autopsies with histological examination. HIV detection was done by virologic and serologic tests, and malaria was diagnosed by histological and parasitological examination. During 26 mo there were 179 maternal deaths, of which 139 (77.6%) had a complete autopsy and formed the basis of this analysis. Of those with test results, 65 women (52.8%) were HIV-positive. Obstetric complications accounted for 38.2% of deaths; haemorrhage was the most frequent cause (16.6%). Nonobstetric conditions accounted for 56.1% of deaths; HIV/AIDS, pyogenic bronchopneumonia, severe malaria, and pyogenic meningitis were the most common causes (12.9%, 12.2%, 10.1% and 7.2% respectively). Mycobacterial infection was found in 12 (8.6%) maternal deaths. Conclusions In this tertiary hospital in Mozambique, infectious diseases accounted for at least half of all maternal deaths, even though effective treatment is available for the four leading causes, HIV/ AIDS, pyogenic bronchopneumonia, severe malaria, and pyogenic meningitis. These observations highlight the need to implement effective and available prevention tools, such as intermittent preventive treatment and insecticide-treated bed-nets for malaria, antiretroviral drugs for HIV/AIDS, or vaccines and effective antibiotics for pneumococcal and meningococcal diseases. Deaths due to obstetric causes represent a failure of health-care systems and require urgent improvement., Introduction Every year approximately 250,000 African women die during pregnancy, delivery, or the puerperium, but we know very little of the causes of these deaths. In Africa maternal mortality ratios [...]
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- 2008
41. Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma: higher incidence and mortality in Africa than in the UK
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Letang, Emilio, Lewis, James J., Bower, Mark, Mosam, Anisa, Borok, Margareth, Campbell, Thomas B., Naniche, Denise, Newsom-Davis, Tom, Shaik, Fahmida, Fiorillo, Suzanne, Miro, Jose M., Schellenberg, David, and Easterbrook, Philippa J.
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- 2013
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42. Quality of care in a differentiated HIV service delivery intervention in Tanzania: A mixed-methods study.
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Okere, Nwanneka Ebelechukwu, Meta, Judith, Maokola, Werner, Martelli, Giulia, van Praag, Eric, Naniche, Denise, Gomez, Gabriela B., Pozniak, Anton, Rinke de Wit, Tobias, de Klerk, Josien, and Hermans, Sabine
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MEDICAL personnel ,HIV-positive persons ,ART associations ,VIRAL load ,SOCIAL clubs ,HIV ,ORPHANS - Abstract
Background: Differentiated service delivery (DSD) offers benefits to people living with HIV (improved access, peer support), and the health system (clinic decongestion, efficient service delivery). ART clubs, 15–30 clients who usually meet within the community, are one of the most common DSD options. However, evidence about the quality of care (QoC) delivered in ART clubs is still limited. Materials and methods: We conducted a concurrent triangulation mixed-methods study as part of the Test & Treat project in northwest Tanzania. We surveyed QoC among stable clients and health care workers (HCW) comparing between clinics and clubs. Using a Donabedian framework we structured the analysis into three levels of assessment: structure (staff, equipment, supplies, venue), processes (time-spent, screenings, information, HCW-attitude), and outcomes (viral load, CD4 count, retention, self-worth). Results: We surveyed 629 clients (40% in club) and conducted eight focus group discussions, while 24 HCW (25% in club) were surveyed and 22 individual interviews were conducted. Quantitative results revealed that in terms of structure, clubs fared better than clinics except for perceived adequacy of service delivery venue (94.4% vs 50.0%, p = 0.013). For processes, time spent receiving care was significantly more in clinics than clubs (119.9 vs 49.9 minutes). Regarding outcomes, retention was higher in the clubs (97.6% vs 100%), while the proportion of clients with recent viral load <50 copies/ml was higher in clinics (100% vs 94.4%). Qualitative results indicated that quality care was perceived similarly among clients in clinics and clubs but for different reasons. Clinics were generally perceived as places with expertise and clubs as efficient places with peer support and empathy. In describing QoC, HCW emphasized structure-related attributes while clients focused on processes. Outcomes-related themes such as improved client health status, self-worth, and confidentiality were similarly perceived across clients and HCW. Conclusion: We found better structure and process of care in clubs than clinics with comparable outcomes. While QoC was perceived similarly in clinics and clubs, its meaning was understood differently between clients. DSD catered to the individual needs of clients, either technical care in the clinic or proximate and social care in the club. Our findings highlight that both clinic and DSD care are required as many elements of QoC were individually perceived. [ABSTRACT FROM AUTHOR]
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- 2022
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43. HIV and malaria interactions: where do we stand?
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González, Raquel, Ataíde, Ricardo, Naniche, Denise, Menéndez, Clara, and Mayor, Alfredo
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- 2012
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44. High prevalence of symptomatic acute HIV infection in an outpatient ward in southern Mozambique: identification and follow-up
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Serna-Bolea, Celia, Muñoz, Jose, Almeida, Jose M, Nhacolo, Ariel, Letang, Emilio, Nhampossa, Tacilta, Ferreira, Eliana, Alonso, Pedro, and Naniche, Denise
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- 2010
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45. The impact of the caregiver mobility on child HIV care in the Manhiça District, Southern Mozambique: A clinical based study.
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Nhampossa, Tacilta, Fernández-Luis, Sheila, Fuente-Soro, Laura, Bernardo, Edson, Nhacolo, Arsenio, Augusto, Orvalho, Nhacolo, Ariel, Sacoor, Charfudin, Saura-Lázaro, Anna, Lopez-Varela, Elisa, and Naniche, Denise
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HIV-positive children ,CHILD care ,CHILDREN'S art ,ANTIRETROVIRAL agents ,MEDICAL records ,HIV - Abstract
Introduction: Manhiça District, in Southern Mozambique harbors high HIV prevalence and a long history of migration. To optimize HIV care, we sought to assess how caregiver's mobility impacts children living with HIV (CLHIV)´s continuation in HIV care and to explore the strategies used by caregivers to maintain their CLHIV on antiretroviral treatment (ART). Methods: A clinic-based cross-sectional survey conducted at the Manhiça District Hospital between December-2017 and February-2018. We enrolled CLHIV with a self-identified migrant caregiver (moved outside of Manhiça District ≤12 months prior to survey) and non-migrant caregiver, matched by the child age and sex. Survey data were linked to CLHIV clinical records from the HIV care and treatment program. Results: Among the 975 CLHIV screened, 285 (29.2%) were excluded due to absence of an adult at the appointment. A total of 232 CLHIV-caregiver pairs were included. Of the 41 (35%) CLHIV migrating with their caregivers, 38 (92.6%) had access to ART at the destination because either the caregivers travelled with it 24 (63%) or it was sent by a family member 14 (36%). Among the 76 (65%) CLHIV who did not migrate with their caregivers, for the purpose of pharmacy visits, 39% were cared by their grandfather/grandmother, 28% by an aunt/uncle and 16% by an adult brother/sister. CLHIV of migrant caregivers had a non-statistically significant increase in the number of previous reported sickness episodes (OR = 1.38, 95%CI: 0.79–2.42; p = 0.257), ART interruptions (OR = 1.73; 95%CI: 0.82–3.63; p = 0.142) and lost-to-follow-up episodes (OR = 1.53; 95%CI: 0.80–2.94; p = 0.193). Conclusions: Nearly one third of the children attend their HIV care appointments unaccompanied by an adult. The caregiver mobility was not found to significantly affect child's retention on ART. Migrant caregivers adopted strategies such as the transportation of ART to the mobility destination to avoid impact of mobility on the child's HIV care. However this may have implications on ART stability and effectiveness that should be investigated in rural areas. [ABSTRACT FROM AUTHOR]
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- 2021
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46. Assessing the prospect of a common health-related stigma reduction response: Cross-perspectives of people living with stigmatised health conditions in Indonesia.
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Rai, Sarju Sing, Syurina, Elena V., Peters, Ruth M.H., Irwanto, Irwanto, Naniche, Denise, and Zweekhorst, Marjolein B.M.
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DIABETES & psychology ,HIV infections & psychology ,SCHIZOPHRENIA ,FOCUS groups ,RESEARCH evaluation ,RESEARCH methodology ,HANSEN'S disease ,HEALTH status indicators ,SOCIAL stigma ,QUANTITATIVE research ,PATIENTS' attitudes ,ATTITUDES toward illness ,HUMAN services programs ,SURVEYS ,QUALITATIVE research ,HEALTH literacy ,EXPERIENCE ,T-test (Statistics) ,COMPARATIVE studies ,QUESTIONNAIRES ,SCALE analysis (Psychology) ,DESCRIPTIVE statistics ,HEALTH attitudes ,JUDGMENT sampling ,STATISTICAL sampling ,STATISTICAL correlation ,DATA analysis software ,THEMATIC analysis ,GROUP psychotherapy - Abstract
This study explored the possibility of a common health-related stigma reduction intervention among people living with HIV, leprosy, schizophrenia and diabetes in Indonesia by assessing their perspectives towards others with the same (within group) and different health conditions (across groups), and willingness to participate in such a program. This mixed-methods study was conducted in West Java, Indonesia between March and June 2018. Eighty participants completed a survey with social distance scale (SDS), while 12 focus group discussion were conducted. Participants with HIV, leprosy and diabetes reported lower within-group SDS scores (4.14 ± 3.65; 4.25 ± 3.95; 7.23 ± 5.31, respectively) while those with schizophrenia reported the highest within-group SDS score (7.76 ± 4.63). Participants with diabetes reported a twofold higher across-group SDS score towards people with the other three health conditions (p < 0.05). The qualitative findings showed that the perception of participants towards one another was shaped by knowledge, understanding and relatedness to the experience of living with health-related stigma. Overall, participants supported the idea of a common stigma reduction intervention for different health conditions, but recommended step-wise implementation of such interventions. Accordingly, this study recommends piloting a common stigma reduction intervention with special focus on fostering understanding, awareness and empathy between people living with different health conditions. [ABSTRACT FROM AUTHOR]
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- 2021
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47. Measles in Travelers: Are We Aware Enough?
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Muñoz, Jose, Alonso, David, Vilella, Anna, Naniche, Denise, Costa, Jose, and Gascón, Joaquim
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- 2008
48. Performance comparison of the Maxim and Sedia Limiting Antigen Avidity assays for HIV incidence surveillance
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Sempa, Joseph B., Welte, Alex, Busch, Michael P., Hall, Jake, Hampton, Dylan, Facente, Shelley N., Keating, Sheila M., Marson, Kara, Parkin, Neil, Pilcher, Christopher D., Murphy, Gary, Grebe, Eduard, Naniche, Denise, CEPHIA (Consortium for the Evaluation and Performance of HIV Incidence Assays), and Peters, Remco PH
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0301 basic medicine ,RNA viruses ,Epidemiology ,HIV Antigens ,Systems Engineering ,HIV Infections ,Pathology and Laboratory Medicine ,Biochemistry ,0302 clinical medicine ,Immunodeficiency Viruses ,Medicine ,Public and Occupational Health ,030212 general & internal medicine ,Multidisciplinary ,Incidence (epidemiology) ,Incidence ,Biochemical markers ,Hiv incidence ,Limiting ,Viral Load ,Research Assessment ,Vaccination and Immunization ,humanities ,Reproducibility ,Infectious Diseases ,HIV epidemiology ,Medical Microbiology ,Performance comparison ,Viral Pathogens ,Population Surveillance ,Viruses ,Marcadors bioquímics ,Engineering and Technology ,Female ,Pathogens ,Infection ,Viral load ,Algorithms ,Research Article ,General Science & Technology ,Science ,Immunology ,Antiretroviral Therapy ,Research and Analysis Methods ,Microbiology ,03 medical and health sciences ,Antigen ,Antiviral Therapy ,Virology ,Retroviruses ,Maxim ,VIH (Virus) ,Humans ,Avidity ,Epidemics ,Microbial Pathogens ,Medicine and health sciences ,business.industry ,HIV (Viruses) ,Consortium for the Evaluation and Performance of HIV Incidence Assays ,Lentivirus ,Organisms ,Biology and Life Sciences ,HIV ,030112 virology ,Kenya ,Good Health and Well Being ,Cross-Sectional Studies ,HIV-1 ,Preventive Medicine ,business ,Quality Assurance ,Viral Transmission and Infection ,Biomarkers - Abstract
BackgroundTwo manufacturers, Maxim Biomedical and Sedia Biosciences Corporation, supply CDC-approved versions of the HIV-1 Limiting Antigen Avidity EIA (LAg) for detecting 'recent' HIV infection in cross-sectional incidence estimation. This study assesses and compares the performance of the two assays for incidence surveillance.MethodsWe ran both assays on a panel of 2,500 well-characterized HIV-1-infected specimens. We analysed concordance of assay results, assessed reproducibility using repeat testing and estimated mean durations of recent infection (MDRIs) and false-recent rates (FRRs) for a range of normalized optical density (ODn) thresholds, alone and in combination with viral load thresholds. We defined three hypothetical surveillance scenarios, similar to the Kenyan and South African epidemics, and a concentrated epidemic. These scenarios allowed us to evaluate the precision of incidence estimates obtained by means of various recent infection testing algorithms (RITAs) based on each of the two assays.ResultsThe Maxim assay produced lower ODn values than the Sedia assay on average, largely as a result of higher calibrator readings (mean OD of 0.749 vs. 0.643), with correlation of normalized readings lower (R2 = 0.908 vs. R2 = 0.938). Reproducibility on blinded control specimens was slightly better for Maxim. The MDRI of a Maxim-based algorithm at the 'standard' threshold (ODn ≤1.5 & VL >1,000) was 201 days (95% CI: 180,223) and for Sedia 171 (152,191). The difference Differences in MDRI were estimated at 32.7 (22.9,42.8) and 30.9 days (21.7,40.7) for the two algorithms, respectively. Commensurately, the Maxim algorithm had a higher FRR in treatment-naive subjects (1.7% vs. 1.1%). The two assays produced similar precision of incidence estimates in the three surveillance scenarios.ConclusionsDifferences between the assays can be primarily attributed to the calibrators supplied by the manufacturers. Performance for surveillance was extremely similar, although different thresholds were optimal (i.e. produced the lowest variance of incidence estimates) and at any given ODn threshold, different estimates of MDRI and FRR were obtained. The two assays cannot be treated as interchangeable: assay and algorithm-specific performance characteristic estimates must be used for survey planning and incidence estimation.
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- 2019
49. Exploring Sustainability in the Era of Differentiated HIV Service Delivery in Sub-Saharan Africa: A Systematic Review.
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Okere, Nwanneka E., Lennox, Laura, Urlings, Lisa, Ford, Nathan, Naniche, Denise, de Wit, Tobias F. Rinke, Hermans, Sabine, and Gomez, Gabriela B.
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- 2021
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50. Identifying HIV care continuum gaps with verbal autopsy
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Bogoch, Isaac I, Gomes, Mireille, Fuente-Soro, Laura, Varo, Rosauro, Naniche, Denise, Sacoor, Charfudin, González, Raquel, Nagelkerke, Nico, Bassat, Quique, and Jha, Prabhat
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- 2018
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