Search

Anti N-methyl-D-aspartate (NMDA) receptor encephalitis is new entity discovered over a decade. It is a type of autoimmune encephalitis characterized by a sequential onset of neuropsychiatric symptoms especially in the young population. Early diagnosis and treatment lead to better outcome and may prevent permanent neurological deficit or even death. Most patients respond well to first-line treatment and the resection of tumors associated with the disease. Here we present a case, which based on radiological findings, was diagnosed as cerebral venous sinus thrombosis (CVST), and was started on anticoagulation. Failure to respond to treatment and development of new movement abnormalities warranted for further investigations and he was found to have anti-NMDA receptor antibody positive in cerebrospinal fluid. Due to overlapping symptoms of CVST and encephalitis, high incidence of cerebral venous sinus thrombosis in this part of the world, and radiological findings, was initially thought to have CVST which was also confirmed on brain imaging. Lack of consent by the parents for a lumbar puncture delayed the definitive diagnosis. Patient developed movement disorder suggestive of autoimmune encephalitis, and this time after extensive counselling, when the cerebrospinal fluid was send for work up, it showed a positive anti-NMDA receptor antibody. He was promptly started on plasmapheresis after which patient had dramatic improvement both in movement abnormalities and neuropsychiatric symptoms.

Multisystem involvement has not been uncommon in SARS-CoV-2 infection. There has been reports of devastating neurological complication both during and after the infection. Here we present a rare case of sino-orbital mucormycosis, diagnosis of which was confirmed on histopathology. Our patient presented with headache, 18 days after her recovery from SARS-CoV-2 infection and was extensively worked up for the cause. Initially she was treated as a severe sinusitis but failure to response to antibiotics treatment warranted for further investigations and imaging. Our patient had to undergo right eye enucleation plus debridement under general anesthesia. She is currently on anti-fungal treatment as advised by infectious disease department.

Abstract The pandemic of severe acute respiratory virus (SARS-CoV-2) is characterized by respiratory symptoms with serious consequences, mainly associated with pneumonia and extreme ARDS. There is a lack of data about pneumothorax associated with COVID-19 infections in current literature. Radiological features in SARS-CoV-2 include subpleural bilateral ground-glass appearance and many areas of irregular consolidation in the lungs. We here present a case of SARS-CoV-2 that was complicated by acute pneumothorax, and despite prompt treatment, that patient could not be saved. A 55-years-old male with no previous lung disease or any other history confirmed to have SARS-CoV-2 pneumonia developed a large pneumothorax on the third day of his presentation and was immediately intubated via a chest tube but could not be saved. SARS-CoV-2 by RT-PCR was positive. The patient expired around 12 h after chest intubation. Recommended treatment could not be started yet as the patient expired before it could be decided.

SARS-CoV-2 infections are transmitted through droplets or through direct contact with secretions from an infected person. The transmission of the virus through tears and other body secretions remains controversial. PCR detection of Covid-19 in the samples/swabs taken from nasopharynx, CSF fluid, and tears, clarifies that the virus may be transmitted through the modes other than aerosol droplets or direct contact. In order to control and prevent this infectious disease, cutting-off the route of transmission will be one of the most important steps. SARS-CoV-2 RNA has been detected in tears and conjunctival samples of patients. The ocular tropism of Covid-19 is still uncertain but contentious.

Plastic bottles are generally recycled by remolding them into numerous products. In this study, waste from plastic bottles was used to fabricate recycled polyethylene terephthalate (r-PET) nanofibers via the electrospinning technique, and high-performance conductive polyethylene terephthalate nanofibers (r-PET nanofibers) were prepared followed by copper deposition using the electroless deposition (ELD) method. Firstly, the electrospun r-PET nanofibers were chemically modified with silane molecules and polymerized with 2-(methacryloyloxy) ethyl trimethylammonium chloride (METAC) solution. Finally, the copper deposition was achieved on the surface of chemically modified r-PET nanofibers by simple chemical/ion attraction. The water contact angle of r-PET nanofibers, chemically modified r-PET nanofibers, and copper deposited nanofibers were 140°, 80°, and 138°, respectively. The r-PET nanofibers retained their fibrous morphology after copper deposition, and EDX results confirmed the presence of copper on the surface of r-PET nanofibers. XPS was performed to analyze chemical changes before and after copper deposition on r-PET nanofibers. The successful deposition of copper one r-PET nanofibers showed an excellent electrical resistance of 0.1 ohms/cm and good mechanical strength according to ASTM D-638.

In this work, we report the synthesis of poly (quinine- co -itaconic acid) incorporated graphene oxide composite that is electro-active and photo-active simultaneously. The poly (quinine- co -itaconic acid)@rGO composite was successfully utilized for electrochemical detection and photocatalytic degradation of hydroquinone (HQ). HQ is recognized as an environmental pollutant because of its high toxicity to human health even at low concentrations. The synthesized composite was characterized using different characterization techniques i.e. Fourier Transform Infrared Spectroscopy (FTIR), Energy Dispersive X-ray Spectroscopy (EDX), Scanning Electron Microscopy (SEM), X-ray Diffractometry (XRD), Brunauer-Emmett-Teller (BET) and zeta potential. The characterization studies revealed the net negative surface charge of -17.6 mV for poly (quinine- co -itaconic acid)@rGO composite that confirms its stability. Moreover, the XRD and FTIR studies confirmed the fabrication of poly (quinine- co -itaconic acid)@rGO composite. The electrochemical properties of synthesized composite were determined via cyclic voltammetry and electrochemical impedance spectroscopy which showed high conductivity and charge transfer kinetics. Under optimized condition, the sensor showed excellent response for hydroquinone i.e. potential window from -0.6 to 0.6 V at scan rate 50 mV s -1 and borate buffer of pH 8 as supporting electrolyte. The developed method was comprehensively validated and found linear between 0.1 to 40 μM of HQ, with limit of detection 0.03 μM and limit of quantification 0.1 μM, respectively. The real water and personal care products samples were used to check the applicability of developed sensor and good percent recovery was achieved. The synthesized poly (quinine- co -itaconic acid)@rGO composite was also utilized for photocatalytic degradation of HQ and the degradation efficiency was obtained as 99% with dosage of 0.5 g L -1 under optimized conditions such as solution pH 7, initial concentration of HQ 10 mg L -1 , catalyst dosage of 5 mg and irradiation time of 40 min, respectively. The degradation efficiency of poly (quinine- co -itaconic acid)@rGO composite was also evaluated in real water samples from industry and river., Competing Interests: All the authors of this manuscript confirm that there is no conflict of interest., (This journal is © The Royal Society of Chemistry.)