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Abstract Background The measurement of the Erythrocyte Sedimentation Rate (ESR) value is a standard procedure performed during a typical blood test. In order to formulate a unified standard of establishing reference ESR values, this paper presents a novel prediction model in which local normal ESR values and corresponding geographical factors are used to predict reference ESR values using multi-layer feed-forward artificial neural networks (ANN). Methods and findings Local normal ESR values were obtained from hospital data, while geographical factors that include altitude, sunshine hours, relative humidity, temperature and precipitation were obtained from the National Geographical Data Information Centre in China. The results show that predicted values are statistically in agreement with measured values. Model results exhibit significant agreement between training data and test data. Consequently, the model is used to predict the unseen local reference ESR values. Conclusions Reference ESR values can be established with geographical factors by using artificial intelligence techniques. ANN is an effective method for simulating and predicting reference ESR values because of its ability to model nonlinear and complex relationships.

Addressing the global challenges of desertification, land degradation, and drought (DLDD), and their impacts on achieving sustainable development goals for coupled human-environmental systems is a key component of the 2030 Agenda for Sustainable Development. In particular, Sustainable Development Goal (SDG) 15.3 aims to, "by 2030, combat desertification, restore degraded land and soil, including land affected by desertification, drought and floods, and strive to achieve a land degradation-neutral world". Addressing this challenge is essential for improving the livelihoods of those most affected by DLDD and for safeguarding against the most extreme effects of climate change. This paper introduces a conceptual framework for improved monitoring of DLDD in the context of United Nations Convention to Combat Desertification (UNCCD) Strategic Objective 2 (SO2) and its expected impacts: food security and adequate access to water for people in affected areas are improved; the livelihoods of people in affected areas are improved and diversified; local people, especially women and youth, are empowered and participate in decision-making processes in combating DLDD; and migration forced by desertification and land degradation is substantially reduced. While it is critical to develop methods and tools for assessing DLDD, work is needed first to provide a conceptual roadmap of the human dimensions of vulnerability in relation to DLDD, especially when attempting to create a globally standardized monitoring approach. [ABSTRACT FROM AUTHOR]

Despite sustained global efforts to avoid, reduce, and reverse land degradation, estimates of land degradation nationally and regionally vary considerably. Land degradation reduces agricultural productivity, impacts the provision of vital ecosystem services, and disproportionately affects vulnerable populations. The 2030 Agenda for Sustainable Development, through Sustainable Development Goal 15.3, sets out to achieve land degradation neutrality (LDN) by improving the livelihoods of those most affected and building resilience in areas affected by or at risk from degradation. The United Nations Convention to Combat Desertification (UNCCD) leads the charge in creating a spatially explicit framework for monitoring and reporting on LDN goals that countries can integrate into their land planning policies. However, it remains difficult to operationalize the integration of biophysical indicators of land degradation with climatic and socio‐economic indicators to assess the impact of land degradation on vulnerable populations. We present an integrative framework that demonstrates how freely available global geospatial data sets can be leveraged through an open‐source platform (Trends.Earth) to simplify and operationalize monitoring and reporting on progress towards achieving LDN. Then, we summarize a suite of data sets and approaches that can be used to understand and quantify the socio‐ecological interactions between drought, land degradation and population exposed to desertification, land degradation and drought. We discuss how improvements in Earth observation data sets and algorithms will allow UNCCD land‐based progress sub‐indicators (changes in primary productivity, land cover, soil organic carbon, drought, and population exposure) to be computed at enhanced spatial resolutions. [ABSTRACT FROM AUTHOR]

Coal resources have always been an important driving force for macroeconomic growth and GDP growth in resource‐rich regions. However, this growth has also caused inequality of household income in developing regions. Using survey data on rural household livelihoods in Shenmu county, Shaanxi Province, in northwestern China, this paper analyzes the relationship between coal exploitation and income inequality. Four multivariate econometric analyses are developed. We find evidence for the resource curse theory of natural resource exploitation leading to inequality: the Gini coefficient for household revenue is discovered to be markedly related with the location of and participation in coal exploitation. Nevertheless, this correlation is not linear. Rather, household income inequality primitively rises with environmental and resource subsidies. We analyze the impacts of household income inequality and contrast the characteristics of household livelihood and location characteristics in the coal exploitation site of northern Shenmu with those in the whole survey site. Our statistical analysis shows that out‐migration, the level of total household income, and convenience of household transportation are the important elements devoting to household income in northern Shenmu, the coal resources endowment region. However, the environmental damage and pollution caused by coal exploitation has substantial negative impacts upon household income, especially for households not participating in coal activities. Overall, we found that coal exploitation did not develop local industries. Adversely, the ecological environment problem and the high subsidy for coal mining caused by the exploitation of coal resources have aggravated the inequality of household income in the sample areas. Additionally, the development of coal resources attracted youth labor from agriculture to the coal industry, which exacerbated the lack of labor force and weakened village agricultural productivity. [ABSTRACT FROM AUTHOR]

The emergence of the SARS-CoV-2 virus in 2019 lead to a global pandemic that altered the activity behavior of most people on our planet. While government regulations and public concern modified visitation patterns to places of interest, little research has examined the nuanced changes in the length of time someone spends at a place, nor the regional variability of these changes. In this work, we examine place visit duration in four major U.S. cities, identify which place types saw the largest and smallest changes, and quantify variation between cities. Furthermore, we identify socio-economic and demographic factors that contribute to changes in visit duration and demonstrate the varying influence of these factors by region. The results of our analysis indicate that the pandemic's impact on visiting behavior varies between cities, though there are commonalities found in certain types of places. Our findings suggest that places of interest within lower income communities experienced less change in visit duration than others. An increase in the percentage of younger, Black or Hispanic populations within a community also resulted in a smaller decrease in visit duration than in other communities. These findings offer insight into the factors that contribute to changes in visiting behavior and the resilience of communities to a global pandemic. [ABSTRACT FROM AUTHOR]

There is large county-level geographic variation in pneumonia and influenza hospitalizations among short-stay and long-stay long-term care facility residents in the United States. Long-term care facilities in counties in the Southern and Midwestern regions had the highest rates of pneumonia and influenza from 2013 to 2015. Future research should identify reasons for these geographic differences. [ABSTRACT FROM AUTHOR]

Despite growing research into the socio-economic aspects of vulnerability [1]–[4], relatively little work has linked population dynamics with climate change beyond the complex relationship between migration and climate change [5]. It is likely, however, that most people experience climate change in situ, so understanding the role of population dynamics remains critical. How a given number of people, in a given location and with varying population characteristics may exacerbate or mitigate the impacts of climate change or how, conversely, they may be vulnerable to climate change impacts are basic questions that remain largely unresolved [6]. This paper explores where and to what extent population dynamics intersect with high exposure to climate change. Specifically, in Eastern Africa's Lake Victoria Basin (LVB), a climate change/health vulnerability hotspot we have identified in prior research [7], we model child undernutrition vulnerability indices based on climate variables, including proxy measures (NDVI) derived from satellite imagery, at a 5-km spatial resolution. Results suggest that vegetation changes associated with precipitation decline in rural areas of sub-Saharan Africa can help predict deteriorating child health. [ABSTRACT FROM PUBLISHER]

The cover image is based on the Research Article Operationalizing an integrative socio‐ecological framework in support of global monitoring of land degradation by Narcisa G. Pricope et al., https://doi.org/10.1002/ldr.4447. [ABSTRACT FROM AUTHOR]

Background: The measurement of the Erythrocyte Sedimentation Rate (ESR) value is a standard procedure performed during a typical blood test. In order to formulate a unified standard of establishing reference ESR values, this paper presents a novel prediction model in which local normal ESR values and corresponding geographical factors are used to predict reference ESR values using multi-layer feed-forward artificial neural networks (ANN). Methods and findings: Local normal ESR values were obtained from hospital data, while geographical factors that include altitude, sunshine hours, relative humidity, temperature and precipitation were obtained from the National Geographical Data Information Centre in China. The results show that predicted values are statistically in agreement with measured values. Model results exhibit significant agreement between training data and test data. Consequently, the model is used to predict the unseen local reference ESR values. Conclusions: Reference ESR values can be established with geographical factors by using artificial intelligence techniques. ANN is an effective method for simulating and predicting reference ESR values because of its ability to model nonlinear and complex relationships. [ABSTRACT FROM AUTHOR]

Indoor and outdoor air pollution is known to contribute to increased lung cancer incidence. This study is the first to address the contribution of home heating fuel and geographical course particulate matter (PM10) concentrations to lung cancer rates in New Hampshire, USA. First, Pearson correlation analysis and geographically weighted regression were used to investigate spatial relationships between outdoor PM10 and lung cancer rates. While the aforementioned analyses did not indicate a significant contribution of PM10 to lung cancer in the state, there was a trend towards a significant association in the northern and southwestern regions of the state. Second, case-control data were used to estimate the contributions of indoor pollution and secondhand smoke to the risk of lung cancer with adjustment for confounders. Increased risk was found among those who used wood or coal to heat their homes for more than 10 winters before the age of 18, with a significant increase in risk per winter. Resulting data suggest that further investigation of the relationship between heating-related air pollution levels and lung cancer risk is needed. [ABSTRACT FROM AUTHOR]

Introduction: There is scarce information about the allocation of health resources in Syria. Pre-existing inequalities were further intensified after the 2011 conflict which displaced over 50% of the population. This study provides an analysis of health inequalities in Syria focusing on spatial access to public hospitals and employs data from 2010, just prior to the outbreak of conflict. Establishing a preconflict snapshot of the health system could serve as a helpful baseline assessment for future studies to measure the impact of the conflict on the health system. Such information could also offer systematic data to guide postconflict reconstruction efforts., Methods: We compared two methods to quantify the inpatient bed access: provider to population ratio (PPR) and two-step floating catchment area (2SFCA) method. We compared PPR calculated at the governorate level with population weighted 2SFCA score calculated at a resolution of 2 km by 2 km. We then aggregated at the governorate level, tested multiple catchment sizes and calculated Gini coefficient for each governorate., Results: We found high inequality in access to public hospitals across and within governorates, especially in the north and eastern regions, where all governorates ranked in the lowest two quintiles using both PPR and 2SFCA. Relatively small governorates in the west and the south had higher spatial access and less inequality. Testing variability in catchment size showed that even at 125 km catchment, 65% of the country had accessibility below national average., Conclusion: Methodologically, the use of 2SFCA provided more nuanced insights about hospital bed allocation than PPR. 2SFCA was able to account for the cross-boundary effect and road network quality. Realistic representation of health accessibility is possible in data-scarce settings such as Syria and could be adapted to assess health access inequalities in conflict and postconflict settings., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Objectives: For persons living with HIV (PLWH) in long-term care, clinic transfers are common and influence sustained engagement in HIV care, as they are associated with significant time out-of-care, low CD4 count, and unsuppressed viral load on re-entry. Despite the geospatial nature of clinic transfers, there exist limited data on the geospatial trends of clinic transfers to guide intervention development. In this study, we investigate the geospatial characteristics and trends of clinic transfers among PLWH on antiretroviral therapy (ART) in the Western Cape Province of South Africa., Design: Retrospective spatial analysis., Setting: PLWH who initiated ART treatment between 2012 and 2016 in South Africa's Western Cape Province were followed from ART initiation to their last visit prior to 2017. Deidentified electronic medical records from all public clinical, pharmacy, and laboratory visits in the Western Cape were linked across space and time using a unique patient identifier number., Participants: 4176 ART initiators in South Africa (68% women)., Methods: We defined a clinic transfer as any switch between health facilities that occurred on different days and measured the distance between facilities using geodesic distance. We constructed network flow maps to evaluate geospatial trends in clinic transfers over time, both for individuals' first transfer and overall., Results: Two-thirds of ART initiators transferred health facilities at least once during follow-up. Median distance between all clinic transfer origins and destinations among participants was 8.6 km. Participant transfers were heavily clustered around Cape Town. There was a positive association between time on ART and clinic transfer distance, both among participants' first transfers and overall., Conclusion: This study is among the first to examine geospatial trends in clinic transfers over time among PLWH. Our results make clear that clinic transfers are common and can cluster in urban areas, necessitating better integrated health information systems and HIV care., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)