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Delonix elata bark was collected, authenticated, dried, coarse-finely powdered and extracted using 70% alcohol and subjected for preliminary phytochemical screening. Total phenolic and flavonoidal contents were determined using UV/ visible spectrophotometer. In addition the silica column chromatographic separation was carried out to separate the phytochemicals of D. elata bark extract. Preliminary phytochemical screening showed positive tests for saponins, flavonoids, tannins and carbohydrates in the alcoholic extract of Delonix elata bark. When the extract was analyzed quantitatively by UV/ visible spectrophotometer, 75 mg/gm of gallic acid equivalent total phenolics and 57.4 mg/gm of rutin equivalent flavonoids were observed. Two phenolic compounds, caffeic acid and apigenin, were isolated and characterized by spectral analysis from the alcoholic extract of the Delonix elata bark. Moreover, HPLC method was employed to analyze the isolated phytoconstituents i.e. caffeic acid and apigenin present in the fraction of alcoholic extract of D. elata bark which showed the similar Rt of separated constituents. The present study reveals the presence of flavonoids in D. elata bark as evidenced by the phytochemical screening, and identification of caffeic acid and apigenin. [ABSTRACT FROM AUTHOR]

The objective of the study was to investigate the alcoholic (ALEBF) extract of B. flabellifer for their hypoglycaemic effects in normal and diabetic rats. Diabetes was induced in rats by single dose administration of alloxan (120 mg/kg, i.p.) or by injecting dexamethasone (10 mg/kg, i.p.) for 10 days. In normal rats, ALEBF (100, 200 and 400 mg/kg) had significantly decreased the blood glucose level in a dose dependent manner after repeated administration for 7 days. In alloxan induced diabetic rats, extract (ALEBF) had decreased blood sugar level and improved glucose tolerance in alloxan induced diabetic rats at the end of 1st, 2nd , 3rd and 4th week after test extract treatment. However, the insulin levels of extract treated group did not significantly change after 28 days treatment with the extract. It did not alter the insulin levels. In alloxan model, repeated dose administration of ALEBF had showed significant increase in body weight, prevention of elimination of sugar in urine and reduced the mortality rate induced by alloxan. In dexamethasone induced insulin resistance diabetic rats, repeated administration of ALEBF inhibited the increase in blood glucose level, improved glucose tolerance and reduced the insulin levels as compared dexamethasone induced diabetic rats.

A series of novel 2-methyl-3-substituted quinazolin-4-(3H)-ones have been synthesized by treating (2-methyl-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The compounds synthesized were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds exhibited significant activity, the compounds VA2, VA3 and VA4 shown more potent analgesic activity, and the compounds VA3 and VA4 shown more potent anti-inflammatory activity than the reference compound diclofinac sodium.