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6 results on '"Mundt, Mark"'

1. Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis

Author

Han, Cliff S., Xie, Gary, Challacombe, Jean F., Altherr, Michael R., Bhotika, Smriti S., Bruce, David, Campbell, Connie S., Campbell, Mary L., Chen, Jin, Chertkov, Olga, Cleland, Cathy, Dimitrijevic, Mira, Doggett, Norman A., Fawcett, John J., Glavina, Tijana, Goodwin, Lynne A., Hill, Karen K., Hitchcock, Penny, Jackson, Paul J., Keim, Paul, Kewalramani, Avinash Ramesh, Longmire, Jon, Lucas, Susan, Malfatti, Stephanie, McMurry, Kim, Meincke, Linda J., Misra, Monica, Moseman, Bernice L., Mundt, Mark, Munk, A. Christine, Okinaka, Richard T., Parson-Quintana, B., Reilly, Lee Philip, Richardson, Paul, Robinson, Donna L., Rubin, Eddy, Saunders, Elizabeth, Tapia, Roxanne, Tesmer, Judith G., Thayer, Nina, Thompson, Linda S., Tice, Hope, Ticknor, Lawrence O., Wills, Patti L., Brettin, Thomas S., and Gilna, Paul

Subjects
Bacillus cereus -- Environmental aspects, Bacillus cereus -- Genetic aspects, Bacillus thuringiensis -- Environmental aspects, Bacillus thuringiensis -- Genetic aspects, Bacillus anthracis -- Environmental aspects, Bacillus anthracis -- Genetic aspects, Genetic research, Biological sciences
Abstract

Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis are closely related gram-positive, spore-forming bacteria of the B. cereus sensu lato group. While independently derived strains of B. anthracis reveal conspicuous sequence homogeneity, environmental isolates of B. cereus and B. thuringiensis exhibit extensive genetic diversity. Here we report the sequencing and comparative analysis of the genomes of two members of the B. cereus group, B. thuringiensis 97-27 subsp, konkukian serotype H34, isolated from a necrotic human wound, and B. cereus E33L, which was isolated from a swab of a zebra carcass in Namibia. These two strains, when analyzed by amplified fragment length polymorphism within a collection of over 300 of B. cereus, B. thuringiensis, and B. anthracis isolates, appear closely related to B. anthracis. The B. cereus E33L isolate appears to be the nearest relative to B. anthracis identified thus far. Whole-genome sequencing of B. thuringiensis 97-27 and B. cereus E33L was undertaken to identify shared and unique genes among these isolates in comparison to the genomes of pathogenic strains B. anthracis Ames and B. cereus G9241 and nonpathogenic strains B. cereus ATCC 10987 and B. cereus ATCC 14579. Comparison of these genomes revealed differences in terms of virulence, metabolic competence, structural components, and regulatory mechanisms.

Published
2006

2. The sequence and analysis of duplication-rich human chromosome 16

Author

Martin, Joel, Han, Cliff, Gordon, Laurie A., Terry, Astrid, Prabhakar, Shyam, She, Xinwei, Xie, Gary, Hellsten, Uffe, Chan, Yee Man, Altherr, Michael, Couronne, Olivier, Aerts, Andrea, Bajorek, Eva, Black, Stacey, Blumer, Heather, Branscomb, Elbert, Brown, Nancy C., Bruno, William J., Buckingham, Judith M., Callen, David F., Campbell, Connie S., Campbell, Mary L., Campbell, Evelyn W., Caoile, Chenier, Challacombe, Jean F., Chasteen, Leslie A., Chertkov, Olga, Chi, Han C., Christensen, Mari, Clark, Lynn M., Cohn, Judith D., Denys, Mirian, Detter, John C., Dickson, Mark, Dimitrijevic-Bussod, Mira, Escobar, Julio, Fawcett, Joseph J., Flowers, Dave, Fotopulos, Dea, Glavina, Tijana, Gomez, Maria, Gonzales, Eidelyn, Goodstein, David, Goodwin, Lynne A., Grady, Deborah L., Grigoriev, Igor, Groza, Matthew, Hammon, Nancy, Hawkins, Trevor, Haydu, Lauren, Hildebrand, Carl E., Huang, Wayne, Israni, Sanjay, Jett, Jamie, Jewett, Phillip B., Kadner, Kristen, Kimball, Heather, Kobayashi, Arthur, Krawczyk, Marie-Claude, Leyba, Tina, Longmire, Jonathan L., Lopez, Frederick, Lou, Yunian, Lowry, Steve, Ludeman, Thom, Manohar, Chitra F., Mark, Graham A., McMurray, Kimberly L., Meincke, Linda J., Morgan, Jenna, Moyzis, Robert K., Mundt, Mark O., Munk, A. Christine, Nandkeshwar, Richard D., Pitluck, Sam, Pollard, Martin, Predki, Paul, Parson-Quintana, Beverly, Ramirez, Lucia, Rash, Sam, Retterer, James, Ricke, Darryl O., Robinson, Donna L., Rodriguez, Alex, Salamov, Asaf, Saunders, Elizabeth H., Scott, Duncan, Shough, Timothy, Stallings, Raymond L., Stalvey, Malinda, Sutherland, Robert D., Tapia, Roxanne, Tesmer, Judith G., Thayer, Nina, Thompson, Linda S., Tice, Hope, Torney, David C., Tran-Gyamfi, Mary, Tsai, Ming, Ulanovsky, Levy E., Ustaszewska, Anna, Vo, Nu, Scott White, P., Williams, Albert L., Wills, Patricia L., Wu, Jung-Rung, Wu, Kevin, Yang, Joan, DeJong, Pieter, Bruce, David, Doggett, Norman A., Deaven, Larry, Schmutz, Jeremy, Grimwood, Jane, Richardson, Paul, Rokhsar, Daniel S., Eichler, Evan E., Gilna, Paul, Lucas, Susan M., Myers, Richard M., Rubin, Edward M., and Pennacchio, Len A.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Joel Martin [1]; Cliff Han [2]; Laurie A. Gordon [1]; Astrid Terry [1]; Shyam Prabhakar [4]; Xinwei She [5]; Gary Xie [1, 2]; Uffe Hellsten [1]; Yee Man Chan [...]

Published
2004
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3. Validation of DNA sequences using mass spectrometry coupled with nucleoside mass tagging

Author

Abdi, Fadi A., Mundt, Mark, Doggett, Norman, Bradbury, Morton E., and Chen, Xian

Subjects
Mass spectrometry -- Research, Genomics -- Research, Nucleotide sequence -- Research, Genetic research, Health
Abstract

A mass spectrometry (MS)-based nucleoside mass tagging method to validate genomic DNA sequences containing ambiguities not resolved by gel electrophoresis is presented. The base composition of the genomic regions of interest is determined from the mass difference between the PCR products.

Published
2002

4. The complete genome sequence of Bacillus thuringiensis Al Hakam

Author

Challacombe, Jean F., Altherr, Michael R., Xie, Gary, Bhotika, Smriti S., Brown, Nancy, Bruce, David, Campbell, Connie S., Campbell, Mary L., Chen, Jin, Chertkov, Olga, Cleland, Cathy, Dimitrijevic, Mira, Doggett, Norman A., Fawcett, John J., Glavina, Tijana, Goodwin, Lynne A., Green, Lance D., Han, Cliff S., Hill, Karen K., Hitchcock, Penny, Jackson, Paul J., Keim, Paul, Kewalramani, Avinash Ramesh, Longmire, Jon, Lucas, Susan, Malfatti, Stephanie, Martinez, Diego, McMurry, Kim, Meincke, Linda J., Misra, Monica, Moseman, Bernice L., Mundt, Mark, Munk, A. Christine, Okinaka, Richard T., Parson-Quintana, B., Reilly, Lee Philip, Richardson, Paul, Robinson, Donna L., Saunders, Elizabeth, Tapia, Roxanne, Tesmer, Judith G., Thayer, Nina, Thompson, Linda S., Tice, Hope, Ticknor, Lawrence O., Wills, Patti L., Gilna, Paul, and Brettin, Thomas S.

Subjects
Bacillus thuringiensis -- Genetic aspects, Bacillus thuringiensis -- Research, Genomes -- Research, Biological sciences
Abstract

Bacillus thuringiensis is an insect pathogen that is widely used as a biopesticide (E. Schnepf, N. Crickmore, J. Van Rie, D. Lereclus, J. Baum, J. Feitelson, D. R. Zeigler, and D. H. Dean, Microbiol. Mol. Biol. Rev. 62:775-806, 1998). Here we report the finished, annotated genome sequence of B. thuringiensis Al Hakam, which was collected in Iraq by the United Nations Special Commission (L. Radnedge, P. Agron, K. Hill, P. Jackson, L. Ticknor, P. Keim, and G. Andersen, Appl. Environ. Microbiol. 69:2755-2764, 2003). doi:10.1128/JB.00241-07

Published
2007

5. The Pathogenomic Sequence Analysis of B. cereus and B. thuringiensis Isolates Closely Related to Bacillus anthracis

Author

Han, Cliff S., Xie, Gary, Challacombe, Jean F., Altherr, Michael R., Smriti, B., Bruce, David, Campbell, Connie S., Campbell, Mary L., Chen, Jin, Chertkov, Olga, Cleland, Cathy, Dimitrijevic-Bussod, M., Doggett, Norman A., Fawcett, John J., Glavina, Tijana, Goodwin, Lynne A., Hill, Karen K., Hitchcock, Penny, Jackson, Paul J., Keim, Paul, Kewalramani, Avinash Ramesh, Longmire, Jon, Lucas, Susan, Malfatti, Stephanie, McMurry, Kim, Meincke, Linda J., Misra, Monica, Moseman, Bernice L., Mundt, Mark, Munk, A. Christine, Okinaka, Richard T., Parson-Quintana, B., Reilly, Lee P., Richardson, Paul, Robinson, Donna L., Rubin, Eddy, Saunders, Elizabeth, Tapia, Roxanne, Tesmer, Judith G., Thayer, Nina, Thompson, Linda S., Tice, Hope, Ticknor, Lawrence O., Wills, Patti L., Gilna, Payl, and Brettin, Thomas S.

Subjects
fungi, Life Sciences, Comparative analysis genomics evolution virulence opportunistic pathogen
Abstract

The sequencing and analysis of two close relatives of Bacillus anthracis are reported. AFLP analysis of over 300 isolates of B. cereus, B. thuringiensis and B. anthracis identified two isolates as being very closely related to B. anthracis. One, a B. cereus, BcE33L, was isolated from a zebra carcass in Nambia; the second, a B. thuringiensis, 97-27, was isolated from a necrotic human wound. The B. cereus appears to be the closest anthracis relative sequenced to date. A core genome of over 3,900 genes was compiled for the Bacillus cereus group, including B anthracis. Comparative analysis of these two genomes with other members of the B. cereus group provides insight into the evolutionary relationships among these organisms. Evidence is presented that differential regulation modulates virulence, rather than simple acquisition of virulence factors. These genome sequences provide insight into the molecular mechanisms contributing to the host range and virulence of this group of organisms.

Published
2005

6. A 360-kb interchromosomal duplication of the human HYDIN locus

Author

Doggett, Norman A., Xie, Gary, Meincke, Linda J., Sutherland, Robert D., Mundt, Mark O., Berbari, Nicolas S., Davy, Brian E., Robinson, Michael L., Rudd, M. Katharine, Weber, James L., Stallings, Raymond L., and Han, Cliff

Subjects
*HUMAN chromosomes, *HUMAN genetics, *CHROMOSOME analysis, *BRAIN diseases
Abstract

Abstract: The HYDIN gene located in human chromosome band 16q22.2 is a large gene encompassing 423 kb of genomic DNA that has been suggested as a candidate for an autosomal recessive form of congenital hydrocephalus. We have found that the human HYDIN locus has been very recently duplicated, with a nearly identical 360-kb paralogous segment inserted on chromosome 1q21.1. The duplication, among the largest interchromosomal segmental duplications described in humans, is not accounted for in the current human genome assembly and appears to be part of a greater than 550-kb contig that must lie within 1 of the 11 sequence gaps currently remaining in 1q21.1. Both copies of the HYDIN gene are expressed in alternatively spliced transcripts. Elucidation of the role of HYDIN in human disease susceptibility will require careful discrimination among the paralogous copies. [Copyright &y& Elsevier]

Published
2006
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