Search

Fast radio bursts (FRBs) are extragalactic radio transients of extraordinary luminosity. Studying the diverse temporal and spectral behaviour recently observed in a number of FRBs may help determine the nature of the entire class. For example, a fast spinning or highly magnetised neutron star might generate the rotation-powered acceleration required to explain the bright emission. Periodic, sub-second components, suggesting such rotation, were recently reported in one FRB, and potentially in two more. Here we report the discovery of FRB 20201020A with Apertif, an FRB showing five components regularly spaced by 0.415 ms. This sub-millisecond structure in FRB 20201020A carries important clues about the progenitor of this FRB specifically, and potentially about that of FRBs in general. We thus contrast its features to the predictions of the main FRB source models. We perform a timing analysis of the FRB 20201020A components to determine the significance of the periodicity. We compare these against the timing properties of the previously reported CHIME FRBs with sub-second quasi-periodic components, and against two Apertif bursts from repeating FRB 20180916B that show complex time-frequency structure. We find the periodicity of FRB 20201020A to be marginally significant at 2.5$\sigma$. Its repeating subcomponents cannot be explained as a pulsar rotation since the required spin rate of over 2 kHz exceeds the limits set by typical neutron star equations of state and observations. The fast periodicity is also in conflict with a compact object merger scenario. These quasi-periodic components could, however, be caused by equidistant emitting regions in the magnetosphere of a magnetar. The sub-millisecond spacing of the components in FRB 20201020A, the smallest observed so far in a one-off FRB, may rule out both neutron-star rotation and binary mergers as the direct source of quasi-periodic FRBs., Comment: 13 pages, 6 figures, 3 tables, supplementary material. Submitted to A&A

Astronomy and astrophysics 658, A2 (2022). doi:10.1051/0004-6361/202140756, The Low-Frequency Array (LOFAR) Long-Baseline Calibrator Survey (LBCS) was conducted between 2014 and 2019 in order to obtain a set of suitable calibrators for the LOFAR array. In this paper, we present the complete survey, building on the preliminary analysis published in 2016 which covered approximately half the survey area. The final catalogue consists of 30 006 observations of 24 713 sources in the northern sky, selected for a combination of high low-frequency radio flux density and flat spectral index using existing surveys (WENSS, NVSS, VLSS, and MSSS). Approximately one calibrator per square degree, suitable for calibration of ≥200 km baselines is identified by the detection of compact flux density, for declinations north of 30° and away from the Galactic plane, with a considerably lower density south of this point due to relative difficulty in selecting flat-spectrum candidate sources in this area of the sky. The catalogue contains indicators of degree of correlated flux on baselines between the Dutch core and each of the international stations, involving a maximum baseline length of nearly 2000 km, for all of the observations. Use of the VLBA calibrator list, together with statistical arguments by comparison with flux densities from lower-resolution catalogues, allow us to establish a rough flux density scale for the LBCS observations, so that LBCS statistics can be used to estimate compact flux densities on scales between 300 mas and 2′′, for sources observed in the survey. The survey is used to estimate the phase coherence time of the ionosphere for the LOFAR international baselines, with median phase coherence times of about 2 min varying by a few tens of percent between theshortest and longest baselines. The LBCS can be used to assess the structures of point sources in lower-resolution surveys, with significant reductions in the degree of coherence in these sources on scales between 2′′ and 300 mas. The LBCS survey sources show a greater incidence of compact flux density in quasars than in radio galaxies, consistent with unified schemes of radio sources. Comparison with samples of sources from interplanetary scintillation (IPS) studies with the Murchison Widefield Array shows consistent patterns of detection of compact structure in sources observed both interferometrically with LOFAR and using IPS., Published by EDP Sciences, Les Ulis

Objectives: More than 40 drugs are available to treat affective disorders. Individual selection of the optimal drug and dose is required to attain the highest possible efficacy and acceptable tolerability for every patient.Methods: This review, which includes more than 500 articles selected by 30 experts, combines relevant knowledge on studies investigating the pharmacokinetics, pharmacodynamics and pharmacogenetics of 33 antidepressant drugs and of 4 drugs approved for augmentation in cases of insufficient response to antidepressant monotherapy. Such studies typically measure drug concentrations in blood (i.e. therapeutic drug monitoring) and genotype relevant genetic polymorphisms of enzymes, transporters or receptors involved in drug metabolism or mechanism of action. Imaging studies, primarily positron emission tomography that relates drug concentrations in blood and radioligand binding, are considered to quantify target structure occupancy by the antidepressant drugs in vivo. Results: Evidence is given that in vivo imaging, therapeutic drug monitoring and genotyping and/or phenotyping of drug metabolising enzymes should be an integral part in the development of any new antidepressant drug.Conclusions: To guide antidepressant drug therapy in everyday practice, there are multiple indications such as uncertain adherence, polypharmacy, nonresponse and/or adverse reactions under therapeutically recommended doses, where therapeutic drug monitoring and cytochrome P450 genotyping and/or phenotyping should be applied as valid tools of precision medicine.

We describe the APERture Tile In Focus (Apertif) system, a phased array feed (PAF) upgrade of the Westerbork Synthesis Radio Telescope which has transformed this telescope into a high-sensitivity, wide field-of-view L-band imaging and transient survey instrument. Using novel PAF technology, up to 40 partially overlapping beams can be formed on the sky simultaneously, significantly increasing the survey speed of the telescope. With this upgraded instrument, an imaging survey covering an area of 2300 deg2 is being performed which will deliver both continuum and spectral line data sets, of which the first data has been publicly released. In addition, a time domain transient and pulsar survey covering 15,000 deg2 is in progress. An overview of the Apertif science drivers, hardware and software of the upgraded telescope is presented, along with its key performance characteristics., 29 pages, 42 figures, accepted for publication by A&A

Early individual differences in executive functions (EFs) are predictive of a range of developmental outcomes. However, despite the importance of EFs, little is known about the processes underlying these early individual differences. Therefore, we investigated the association between 14-month-old infants’ attention on a reaching version of the A-not-B task and task success. We hypothesized that both strategic focused attention (measured as percentage looking time towards the correct location during delay) and attentional flexibility (measured as number of looks per second to available stimuli during delay) would relate positively to task performance. Infants performed the A-not-B task wearing a head-mounted eye tracker (N = 24). Results were trial-dependent and partially supported the hypotheses: (1) infants who were better able to flexibly shift attention between available stimuli on the first pre-switch trial showed better task performance overall; and (2) strategic focused attention to the hiding location during the first switch trial was positively related to performance on that particular trial only (trend-level effect). Thus, the study shows preliminary evidence that particularly attentional flexibility is a key factor underlying EF performance in young children. Advantages and challenges of working with head-mounted eye tracking in infants are discussed.