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25 results on '"Moris, Maria"'

1. Plastic pigtail vs lumen-apposing metal stents for drainage of walled-off necrosis (PROMETHEUS study): an open-label, multicenter randomized trial

Author

Gornals, Joan B., Velasquez-Rodriguez, Julio G., Bas-Cutrina, Francesc, Garcia Garcia De Paredes, Ana, Esteban, Jose-Miguel, Teran, Alvaro, Gonzalez-Huix, Ferran, Perez-Miranda, Manuel, Guarner-Argente, Carlos, Vila, Juan J., Garcia-Sumalla, Albert, Foruny, Jose Ramon, Fisac-Vazquez, Joaquin, Moris, Maria, Miquel-Salas, Isabel, De-la-Serna Higuera, Carlos, Murzi-Pulgar, Marianette, Sanchez-Yague, Andres, Salord, Silvia, Ruiz-Osuna, Sandra, Busquets, Juli, Sanllorente-Melenchon, Mireia, Videla, Sebas, Moreno, Ramon, Tebe-Cordomi, Cristian, Hereu, Pilar, and Vazquez-Sequeiros, Enrique

Published
2024
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3. Endoscopic Vacuum Therapy for Upper Gastrointestinal Leaks and Perforations: Analysis From a Multicenter Spanish Registry.

Author

Momblan, Dulce, Gimeno Garcia, Antonio Z., Busquets, David, Juzgado, Diego, García Lledó, Javier, Ferrero, Esther, Tejedor-Tejada, Javier, Junquera, Félix, Díaz-Tasende, José, Moris, Maria, Rodriguez de Santiago, Enrique, Gornals, Joan, Garrido, Carmen, Gonzalez-Vazquez, Santiago, Guarner-Argente, Carlos, Repiso, Alejandro, Miguel Esteban, Jose, Loras, Carme, Seoane, Agustín, and Fernández-Simon, Alejandro

Published
2023
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7. TERAPIA DE VACÍO ENDOSCÓPICA EN EL TRATAMIENTO DE LAS DEHISCENCIAS DE SUTURA ANASTOMÓTICAS Y PERFORACIONES DEL TRACTO DIGESTIVO SUPERIOR. RESULTADOS DEL REGISTRO MULTICÉNTRICO ESPAÑOL

Author

Garcia, Oriol Sendino, Busquets, David, Gimeno-García, Antonio Z., Juzgado, Diego, García-Lledó, Javier, Ferrero, Esther, Tejedor, Javier, Junquera, Félix, Díaz-Tasende, José, Moris, María, Gornals, Joan, Garrido, Carmen, González, Santiago, Guarner-Argente, Carlos, Repiso, Alejandro, Esteban, José Miguel, Loras, Carme, Seoane, Agustín, Cárdenas, Andrés, Córdova, Henry, Fernández-Simón, Alejandro, Ibarzábal, Ainitze, Morales, Xavier, Curell, Anna, Luzko, Irina Sofía, de Lacy, Antonio Maria, Llach, Josep, and Momblán, Dulce

Published
2023
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9. Intraductal papillary mucinous neoplasms and mucinous cystadenomas: current status and recommendations

Author

Moris, Maria and Wallace, Michael B.

Subjects
CAM, MCAs, Malignancy, TPMI, Quistes pancreáticos, IPMNs, Pancreatic cyst, Malignidad
Abstract

The real prevalence of pancreatic cystic lesions remains unknown. The malignant potential of some of these lesions remains a cause for significant concern. Thus, it is mandatory to develop a strategy to clearly discriminate those cysts with a potential for malignant transformation from those that do not carry any significant risk. Intraductal papillary mucinous neoplasms and mucinous cystadenomas are mucinous cystic neoplasms with a known malignant potential that have gained greater recognition in recent years. However, despite the numerous studies that have been carried out, their differential diagnosis among other cysts subtypes and their therapeutic approach continue to be a challenge for clinicians. This review contains a critical approach of the current recommendations and management strategies regarding intraductal papillary mucinous neoplasms and mucinous cystadenomas, as well as highlighting the limitations exposed in current guidelines. La prevalencia real de las lesiones quísticas de páncreas sigue siendo una incógnita. El potencial de malignidad de algunas de estas lesiones supone una causa de preocupación significativa en la práctica clínica diaria. Por lo tanto, es necesario determinar una estrategia para poder discriminar claramente los quistes potencialmente malignos de aquellos que no suponen ningún tipo de riesgo. Los tumores papilares mucinosos intraductales y los cistoadenomas mucinosos son neoplasias quísticas mucinosas potencialmente malignas que han ido ganando mayor importancia y reconocimiento en los últimos años. Sin embargo, pese a los múltiples estudios que se han realizado hasta la fecha, su diagnóstico diferencial respecto a otros subtipos de quistes, así como su manejo terapéutico, continúan suponiendo un reto. Este manuscrito contiene una revisión crítica de las recomendaciones actuales y de las estrategias en el manejo de los tumores papilares mucinosos intraductales y los cistoadenomas mucinosos, así como hace hincapié en las limitaciones de las guías actuales.

Published
2017

23. Diagnostic Accuracy of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology, Carcinoembryonic Antigen, and Amylase in Intraductal Papillary Mucinous Neoplasm

Author

Michael B. Wallace, Verna Skinner, Massimo Raimondo, Horacio J. Asbun, Selene Manfrè, Paolo Giorgio Arcidiacono, Maria Chiara Petrone, Maria Moris, Timothy A. Woodward, Pietro Fusaroli, John A. Stauffer, Claudio De Angelis, Moris, Maria, Raimondo, Massimo, Woodward, Timothy A., Skinner, Verna, Arcidiacono, Paolo G., Petrone, Maria C., De Angelis, Claudio, Manfrè, Selene, Fusaroli, Pietro, Asbun, Horacio, Stauffer, John, Wallace, Michael B, Moris, M, Raimondo, M, Woodward, Ta, Skinner, V, Arcidiacono, P. G., Petrone, Mc, De Angelis, C, Manfrè, S, Fusaroli, P, Asbun, H, Stauffer, J, and Wallace, Mb.

Subjects
Male, Endoscopic ultrasound, medicine.medical_specialty, Pathology, endocrine system diseases, Endocrinology, Diabetes and Metabolism, specificity, Sensitivity and Specificity, 03 medical and health sciences, 0302 clinical medicine, Carcinoembryonic antigen, Endocrinology, Cytology, medicine, Carcinoma, Internal Medicine, Humans, Cyst, Endoscopic Ultrasound-Guided Fine Needle Aspiration, Pancreas, EUS, Aged, cyst, Intraductal papillary mucinous neoplasm, biology, medicine.diagnostic_test, Hepatology, business.industry, IPMN, Reproducibility of Results, Middle Aged, medicine.disease, sensitivity, Adenocarcinoma, Mucinous, Carcinoma, Papillary, Carcinoembryonic Antigen, Pancreatic Neoplasms, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Amylases, biology.protein, Adenocarcinoma, Female, 030211 gastroenterology & hepatology, Radiology, business, Carcinoma, Pancreatic Ductal
Abstract

Objectives The aim of this study was to determine the accuracy of cytology, carcinoembryonic antigen (CEA), and amylase levels in the preoperative diagnosis of intraductal papillary mucinous neoplasms (IPMNs). Methods An international registry was started in 2005 and included patients with clinically suspected IPMNs. Those who underwent surgery and had preoperative endoscopic ultrasonography fine-needle aspiration were selected for the study. Results One hundred eighty patients were included. Cytological analysis for neoplastic cells in IPMNs showed high specificity (87.8%) but low sensitivity (39.4%). The median CEA level was 525.5 ng/mL (n = 78) in IPMNs versus 9.7 ng/mL in nonmucinous cysts (n = 6), showing an area under the receiver operating characteristic curve (AUC) of 0.87. The optimal cutoff CEA value for distinguishing IPMN from nonmucinous cysts was 129 ng/mL. At this level, the sensitivity was 76.9%, and specificity was 83.3%, yielding a positive predictive value of 95.9% and a negative predictive value of 41.9%. Carcinoembryonic antigen was a poor predictor of neoplasia in IPMNs (AUC = 0.55). Amylase did not distinguish IPMNs from mucinous cystadenomas (MCAs) (median, 3759 U/L [n = 28 IPMNs] and 497 U/L [n = 3 MCAs], AUC = 0.65). Conclusions Cytology has a limited role because of its lack of sensitivity. Carcinoembryonic antigen modestly differentiated between mucinous and nonmucinous lesions. Amylase did not distinguish IPMNs versus MCAs.

Published
2016

24. Intraductal papillary mucinous neoplasms and mucinous cystadenomas: current status and recommendations.

Author

Moris M and Wallace MB

Subjects
Diagnosis, Differential, Humans, Practice Guidelines as Topic, Prognosis, Cystadenoma, Mucinous diagnosis, Cystadenoma, Mucinous pathology, Cystadenoma, Mucinous therapy, Pancreatic Neoplasms diagnosis, Pancreatic Neoplasms pathology, Pancreatic Neoplasms therapy
Abstract

The real prevalence of pancreatic cystic lesions remains unknown. The malignant potential of some of these lesions remains a cause for significant concern. Thus, it is mandatory to develop a strategy to clearly discriminate those cysts with a potential for malignant transformation from those that do not carry any significant risk. Intraductal papillary mucinous neoplasms and mucinous cystadenomas are mucinous cystic neoplasms with a known malignant potential that have gained greater recognition in recent years. However, despite the numerous studies that have been carried out, their differential diagnosis among other cysts subtypes and their therapeutic approach continue to be a challenge for clinicians. This review contains a critical approach of the current recommendations and management strategies regarding intraductal papillary mucinous neoplasms and mucinous cystadenomas, as well as highlighting the limitations exposed in current guidelines.

Published
2017
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25. Thermal ablation of pancreatic cyst with a prototype endoscopic ultrasound capable radiofrequency needle device: A pilot feasibility study.

Author

Moris M, Atar M, Kadayifci A, Krishna M, Librero A, Richie E, Brugge W, and Wallace MB

Abstract

Background and Objectives: Pancreatic cysts are evaluated by endoscopic ultrasound and fine needle aspiration (EUS). The only accepted treatment is pancreatectomy, which is associated with morbidity and mortality. This study evaluated the optimal thermal dosimetry of a novel radiofrequency ablation device using a standard electrosurgical unit in ex vivo cyst models., Methods: A modified EUS 22-gauge monopolar needle prototype with a tip electrode connected to a standard electrosurgical unit (Erbe USA, Marietta, GA, USA) was used to induce a subboiling point temperature. A cyst model was created using 2-cm sections of porcine small intestine ligated and filled with saline. After ablation, the cyst models were prepared for pathological evaluation. The epithelial layers were measured in at least two different sites with a micrometer and compared with the corresponding control sample., Results: Thirty-two cyst models were ablated with maximum temperatures of 50°C, 60°C, 90°C, and 97°C in 8, 11, 11, and 2 cysts, respectively. Longer ablation times were required to induce higher temperatures. A trend in the reduction in thickness of the measured layers was observed after exposure to higher temperatures. A temperature over 50°C was required for the ablation of the muscularis, submucosa, and villi, and over 60°C was required to ablate the mucosal crypts., Conclusions: In a preclinical model, a novel radiofrequency EUS-capable needle connected to a standard electrosurgical unit using standard low-voltage coagulation provided ablation in a temperature-dependent fashion with a threshold of at least 60°C and a safe cyst margin below 97°C. This potentially will allow low-cost, convenient cyst ablation.

Published
2017
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