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217 results on '"Morioka, Daisuke"'

1. Evaluating Combinations of Biological and Clinicopathologic Factors Linked to Poor Outcomes in Resected Colorectal Liver Metastasis: An External Validation Study

Author

Sasaki, Kazunari, Wang, Jane, Kamphues, Carsten, Buettner, Stefan, Gagniere, Johan, Ardilles, Victoria, Imai, Katsunori, Wagner, Doris, Pozios, Ioannis, Papakonstantinou, Dimitris, Pikoulis, Emmanouil, Antoniou, Efstathios, Morioka, Daisuke, Løes, Inger Marie, Lønning, Per Eystein, Kornprat, Peter, Aucejo, Federico N., Baba, Hideo, de Santibañes, Eduardo, Kaczirek, Klaus, Burkhart, Richard, Endo, Itaru, Beyer, Katharina, Kreis, Martin E., Pawlik, Timothy M., and Margonis, Georgios Antonios

Published
2024
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10. The Prognostic Impact of Primary Tumor Site Differs According to the KRAS Mutational Status: A Study By the International Genetic Consortium for Colorectal Liver Metastasis

Author

Margonis, Georgios Antonios, Amini, Neda, Buettner, Stefan, Kim, Yuhree, Wang, Jaeyun, Andreatos, Nikolaos, Wagner, Doris, Sasaki, Kazunari, Beer, Andrea, Kamphues, Carsten, Morioka, Daisuke, Løes, Inger Marie, Imai, Katsunori, He, Jin, Pawlik, Timothy M., Kaczirek, Klaus, Poultsides, George, Lønning, Per Eystein, Burkhart, Richard, Endo, Itaru, Baba, Hideo, Mischinger, Hans Joerg, Aucejo, Federico N., Kreis, Martin E., Wolfgang, Christopher L., and Weiss, Matthew J.

Published
2019
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28. Mutant KRAS as a prognostic biomarker after hepatectomy for rectal cancer metastases: Does the primary disease site matter?

Author

Amini, Neda, Andreatos, Nikolaos, Margonis, Georgios Antonios, Buettner, Stefan, Wang, Jaeyun, Galjart, Boris, Wagner, Doris, Sasaki, Kazunari, Angelou, Anastasios, Sun, Jinger, Kamphues, Carsten, Beer, Andrea, Morioka, Daisuke, Løes, Inger Marie, Antoniou, Efstathios, Imai, Katsunori, Pikoulis, Emmanouil, He, Jin, Kaczirek, Klaus, and Poultsides, George

Abstract

Background: The prognostic implication of mutant KRAS (mKRAS) among patients with primary disease in the rectum remains unknown. Methods: From 2000 to 2018, patients undergoing hepatectomy for colorectal liver metastases at 10 collaborating international institutions with documented KRAS status were surveyed. Results: A total of 834 (65.8%) patients with primary colon cancer and 434 (34.2%) patients with primary rectal cancer were included. In patients with primary colon cancer, mKRAS served as a reliable prognostic biomarker of poor overall survival (OS) (hazard ratio [HR]: 1.58, 95% CI 1.28‐1.95) in the multivariable analysis. Although a trend towards significance was noted, mKRAS was not found to be an independent predictor of OS in patients with primary rectal tumors (HR 1.34, 95% CI 0.98‐1.80). For colon cancer, the specific codon impacted in mKRAS appears to reflect underlying disease biology and oncologic outcomes, with codon 13 being associated with particularly poor OS in patients with left‐sided tumors (codon 12, HR 1.56, 95% CI 1.22‐1.99; codon 13, HR 2.10 95% CI 1.43‐3.08;). Stratifying the rectal patient population by codon mutation did not confer prognostic significance following hepatectomy. Conclusions: While the left‐sided colonic disease is frequently grouped with rectal disease, our analysis suggests that there exist fundamental biologic differences that drive disparate outcomes. Although there was a trend toward significance of KRAS mutations for patients with primary rectal cancers, it failed to achieve statistical significance. [ABSTRACT FROM AUTHOR]

Published
2022
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46. HEMOBILIA CAUSED BY PSEUDOANEURYSM OF THE CYSTIC ARTERY

Author

Morioka, Daisuke, Ueda, Michio, Baba, Noriyuki, Kubota, Kaori, Otsuka, Yuichi, Akiyama, Hirotoshi, Endo, Itaru, Sekido, Hitoshi, Tajima, Yusuke, Nakanishi, Makoto, Togo, Shinji, and Shimada, Hiroshi

Published
2004

49. Performance of two prognostic scores that incorporate genetic information to predict long‐term outcomes following resection of colorectal cancer liver metastases: An external validation of the MD Anderson and JHH‐MSK scores.

Author

Sasaki, Kazunari, Gagnière, Johan, Dupré, Aurélien, Ardiles, Victoria, O'Connor, Juan Manuel, Wang, Jaeyun, Moro, Amika, Morioka, Daisuke, Buettner, Stefan, Gau, Laurence, Ribeiro, Mathieu, Wagner, Doris, Andreatos, Nikolaos, Løes, Inger Marie, Fitschek, Fabian, Kaczirek, Klaus, Lønning, Per Eystein, Kornprat, Peter, Poultsides, George, and Kamphues, Carsten

Abstract

Introduction: Two novel clinical risk scores (CRS) that incorporate KRAS mutation status were developed: modified CRS (mCRS) and GAME score. However, they have not been tested in large national and international cohorts. The aim of this study was to validate the prognostic discrimination utility and determine the clinical usefulness of the two novel CRS. Methods: Patients undergoing hepatectomy for CRLM (2000‐2018) in 10 centers were included. The discriminatory abilities of mCRS, GAME, and Fong CRS were evaluated using Harrell's C‐index and Akaike's Information Criterion. Results: In the entire cohort, the C‐index of the GAME score (0.61) was significantly higher than those of Fong score (0.57) and mCRS (0.54), while the C‐Index of mCRS was significantly lower than that of Fong score. When we compared the models in the various geographical regions, the C‐index of GAME score was significantly higher than that of mCRS in North America, Europe, and South America. The AIC of Fong score, mCRS, and GAME score were 14 405, 14 447, and 14 319, respectively. Conclusion: In conclusion, using the largest and most heterogenous population of CRLM patients with known KRAS status, this independent, external validation demonstrated that the GAME score outperforms both the traditional Fong score and mCRS. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Subcutaneous switching suture technique for hernia defect closure during laparoscopic ventral and incisional hernia repair.

Author

Morioka, Daisuke, Izumisawa, Yusuke, Ohyama, Norio, Yamaguchi, Kazuya, Horii, Nobutoshi, Asano, Fumio, Miura, Masaru, and Sato, Yoshiki

Subjects
*SUTURING, *HERNIA, *LAPAROSCOPIC surgery, *ABDOMINAL wall, *OPERATIVE surgery, *VENTRAL hernia
Abstract

Introduction: A vertical penetration of the thread through the abdominal wall for the hernia defect closure in laparoscopic ventral/incisional hernia repair (LVIHR) is difficult especially in the large defect cases when applying the existing techniques. Materials: Sixteen LVIHRs were performed using the suture technique for defect closure we newly developed. Surgical technique: With the subcutaneous switching, our technique only requires the suture‐passer and easily enables the vertical penetration of the thread through the abdominal muscular wall even in the large defect cases. Discussion: The defect closure in LVIHR tends to be complicated in the large defect cases. Thus, we devised this technique for the easy, reliable, and firm closure even in the large defect cases. Although the sample size was currently very small, we consider that the favorable outcomes have been obtained through our technique because any noticeable complications, such as mesh bulging or recurrence, have not been observed currently. [ABSTRACT FROM AUTHOR]

Published
2021
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