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4. Prehabilitation exercise before oesophagectomy: long-term follow-up of patients declining/withdrawing from the program.

Author

Knight, William, Moore, Jonathan L., Whyte, Greg P., Zylstra, Janine, Lane, Andrew M., Pate, James, Gervais-Andre, Louise, Maisey, Nick, Hill, Mark, Tham, Gemma, Lagergren, Jesper, Kelly, Mark, Baker, Cara, Van Hemelrijck, Mieke, Goh, Vicky, Gossage, James, Browning, Mike, and Davies, Andrew R.

Subjects
*PREHABILITATION, *ESOPHAGECTOMY
Published
2023
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5. Pathologic Lymph Node Regression After Neoadjuvant Chemotherapy Predicts Recurrence and Survival in Esophageal Adenocarcinoma: A Multicenter Study in the United Kingdom.

Author

Moore, Jonathan L., Green, Michael, Santaolalla, Aida, Deere, Harriet, Evans, Richard P.T., Elshafie, Mona, Lavery, Anita, McManus, Damian T., McGuigan, Andrew, Douglas, Rosalie, Horne, Joanne, Walker, Robert, Mir, Hira, Terlizzo, Monica, Kamarajah, Sivesh K., Van Hemelrijck, Mieke, Maisey, Nick, Sita-Lumsden, Ailsa, Ngan, Sarah, and Kelly, Mark

Published
2023
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9. Effect of peri-operative chemotherapy regimen on survival in the treatment of locally advanced oesophago-gastric adenocarcinoma – A comparison of the FLOT and 'MAGIC' regimens.

Author

Moore, Jonathan L., Kumar, Sacheen, Santaolalla, Aida, Patel, Pranav H., Kapiris, Matthaios, Van Hemelrijck, Mieke, Maisey, Nick, Hill, Mark, Lagergren, Jesper, Gossage, James A., Kelly, Mark, Chaudry, Asif, Allum, William H., Baker, Cara R., Cunningham, David, and Davies, Andrew R.

Subjects
*STOMACH tumors, *ADENOCARCINOMA, *ADJUVANT chemotherapy, *DRUG efficacy, *PERIOPERATIVE care, *FOLINIC acid, *CONFIDENCE intervals, *ANTINEOPLASTIC agents, *SURGICAL complications, *CANCER patients, *ANTIMETABOLITES, *FLUOROURACIL, *COMPARATIVE studies, *EPIRUBICIN, *CISPLATIN, *DOCETAXEL, *SURVIVAL analysis (Biometry), *DESCRIPTIVE statistics, *DRUGS, *OXALIPLATIN, *PROGRESSION-free survival, *PATIENT compliance, *ESOPHAGEAL tumors, *LONGITUDINAL method, *PROPORTIONAL hazards models, *EVALUATION
Abstract

Peri-operative chemotherapy improves survival in patients with locally advanced oesophago-gastric adenocarcinoma. Two regimens with proven survival benefits are epirubicin, cisplatin plus capecitabine or fluorouracil (Medical Research Council Adjuvant Gastric Infusional Chemotherapy, MAGIC) and fluorouracil plus leucovorin, oxaliplatin, and docetaxel (FLOT). This study aimed to compare the effect of these regimens on survival (primary aim) and pathological response, surgical complications, adverse events and chemotherapy completion rates. Cohort study including 946 patients treated with FLOT (n = 257) or MAGIC (n = 689) who underwent surgical resection for oesophageal (n = 743) or gastric (n = 203) adenocarcinoma between 2002 and 2021 at St Thomas' Hospital or The Royal Marsden Hospital, London, UK. Survival analysis was performed using multivariable Cox regression, providing hazard ratios (HRs) with 95% confidence intervals (CIs) adjusted for age, sex, clinical T-stage, clinical N-stage, tumour grade and presence of signet ring cells. Patients treated with FLOT had better overall survival (HR = 0.69, 95% CI 0.50–0.94) and disease-free survival (HR = 0.75, 95% CI 0.58–0.98) than MAGIC. Patients treated with FLOT were more likely to have a complete pathological response (9.5% FLOT versus 5.5% MAGIC, p = 0.027) and were less likely to have a positive resection margin (19.1% FLOT versus 32.2% MAGIC, p < 0.001). The stratified analysis revealed similar results for oesophageal and gastric tumours. Rates of surgical complications, chemotherapy-associated adverse events and completion were similarly distributed between treatment groups. Patients with oesophageal or gastric adenocarcinoma treated with peri-operative FLOT had better survival and pathological response than those treated with peri-operative MAGIC. Rates of surgical complications, adverse events and chemotherapy completion were comparable. • Better survival in patients treated with fluorouracil plus leucovorin, oxaliplatin and docetaxel. • Better pathological and radiological response to chemotherapy with FLOT. • Higher rates of complete pathological response in patients treated with FLOT. • Patients treated with FLOT were less likely to have a positive resection margin. • Comparable rates of surgical complications, adverse events and chemo completion. [ABSTRACT FROM AUTHOR]

Published
2022
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10. AN OVERVIEW OF THE NEW.

Author

Rhoads, Mark B. and Moore, Jonathan L.

Subjects
*STEM education, *FOREIGN students, *INDUSTRIAL relations, *EMPLOYER attitudes
Published
2016

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