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3 results on '"Mon-Gy Chen"'

1. Palifermin for oral mucositis after intensive therapy for hemotologic cancers

Author

Spielberger, Ricardo, Bensinger, William, Stiff, Patrick, Gentile, Teresa, Kewalramani, Tarun, dorf, Daniel, Shea, Thomas, Hansen, Keith, Yanovich, Saul, Noga, Stephen, Sung, Eric C., LeMaistre, C. Frederick, McCarthy, John, Blazar, Bruce, Emmanouilides, Christos, Mon-Gy Chen, and Elhardt, Dieter

Subjects
Chemotherapy -- Health aspects, Blood diseases -- Risk factors, Blood diseases -- Care and treatment, Oral mucosa -- Risk factors, Oral mucosa -- Care and treatment, Cancer -- Chemotherapy, Cancer -- Health aspects
Abstract

The ability of palifermin is tested to decrease oral mucosal injury induced by cytotoxic therapy was tested. It was found that palifermin reduced the duration and severity of oral mucositis after intensive chemotherapy and radiotherapy for hematologic cancers.

Published
2004

2. Palifermin for Oral Mucositis after Intensive Therapy for Hematologic Cancers

Author

Daniel J. Weisdorf, Teresa Gentile, Mon-Gy Chen, Thomas B. Shea, Ricardo Spielberger, Patrick J. Stiff, Bruce R. Blazar, Dieter Elhardt, Tarun Kewalramani, Saul Yanovich, William I. Bensinger, Eric C. Sung, C. Frederick LeMaistre, Stephen J. Noga, Christos Emmanouilides, John M. McCarty, and Keith Hansen

Subjects
Adult, Male, medicine.medical_specialty, Fibroblast Growth Factor 7, Neutropenia, Transplantation Conditioning, Adolescent, medicine.medical_treatment, Antineoplastic Agents, Placebo, Gastroenterology, Double-Blind Method, Internal medicine, Mucositis, Medicine, Humans, Stomatitis, Aged, Chemotherapy, Radiotherapy, business.industry, Hematopoietic Stem Cell Transplantation, Mouth Mucosa, General Medicine, Total body irradiation, Middle Aged, medicine.disease, Combined Modality Therapy, Surgery, Transplantation, Radiation therapy, Fibroblast Growth Factors, Palifermin, Hematologic Neoplasms, Female, Parenteral Nutrition, Total, business, medicine.drug
Abstract

BACKGROUND Oral mucositis is a complication of intensive chemotherapy and radiotherapy with no effective treatment. We tested the ability ofpalifermin (recombinant human keratinocyte growth factor) to decrease oral mucosal injury induced by cytotoxic therapy. METHODS This double-blind study compared the effect ofpalifermin with that of a placebo on the development of oral mucositis in 212 patients with hematologic cancers; 106 patients received palifermin (60 μg per kilogram ofbody weight per day) and 106 received a placebo intravenously for three consecutive days immediately before the initiation of conditioning therapy (fractionated total-body irradiation plus high-dose chemotherapy) and after autologous hematopoietic stem-cell transplantation. Oral mucositis was evaluated daily for 28 days after transplantation. RESULTS The incidence oforal mucositis of World Health Organization (WHO) grade 3 or 4 was 63 percent in the palifermin group and 98 percent in the placebo group (P

Published
2004
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